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Conserved domains on  [gi|2156709089|ref|WP_230453594|]
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NAD(P)/FAD-dependent oxidoreductase [Tropheryma whipplei]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11422994)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0050660|GO:0016491
PubMed:  33684359

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-346 6.17e-31

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 119.45  E-value: 6.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRP--RNAATIAVHGVIA-REGISPHALRSDGGKALISFGGKILPSEVVS 79
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEPggQLATTKEIENYPGfPEGISGPELAERLREQAERFGAEILLEEVTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  80 VvwtgdqssvglspislsidgsvaepesccaasaisdmksnsssegagtegagtRKENQWYEVDAllhpaRNREKFLAKT 159
Cdd:COG0492    82 V-----------------------------------------------------DKDDGPFRVTT-----DDGTEYEAKA 103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 160 VLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFDSVGLIGYGPDAVDIlqrAIYLSFRVSS--IVVFYNQFNQA- 236
Cdd:COG0492   104 VIIATGAGPRKLGLPGEEEFEGRGVSYCATCDGFFFRGKDVVVVGGGDSALEE---ALYLTKFASKvtLIHRRDELRASk 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 237 --QKGILENLGVKIV-ETQLTEVL----LEEGAFTGFMDAAGKSHTVSSAFLRPIWKPNVDFIKNPSL--NSQGFIITGN 307
Cdd:COG0492   181 ilVERLRANPKIEVLwNTEVTEIEgdgrVEGVTLKNVKTGEEKELEVDGVFVAIGLKPNTELLKGLGLelDEDGYIVVDE 260

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2156709089 308 DGRLNRGNMWAAGDVTG--IGQVSIAAGQGASVALDIGRYL 346
Cdd:COG0492   261 DMETSVPGVFAAGDVRDykYRQAATAAGEGAIAALSAARYL 301
 
Name Accession Description Interval E-value
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-346 6.17e-31

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 119.45  E-value: 6.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRP--RNAATIAVHGVIA-REGISPHALRSDGGKALISFGGKILPSEVVS 79
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEPggQLATTKEIENYPGfPEGISGPELAERLREQAERFGAEILLEEVTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  80 VvwtgdqssvglspislsidgsvaepesccaasaisdmksnsssegagtegagtRKENQWYEVDAllhpaRNREKFLAKT 159
Cdd:COG0492    82 V-----------------------------------------------------DKDDGPFRVTT-----DDGTEYEAKA 103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 160 VLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFDSVGLIGYGPDAVDIlqrAIYLSFRVSS--IVVFYNQFNQA- 236
Cdd:COG0492   104 VIIATGAGPRKLGLPGEEEFEGRGVSYCATCDGFFFRGKDVVVVGGGDSALEE---ALYLTKFASKvtLIHRRDELRASk 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 237 --QKGILENLGVKIV-ETQLTEVL----LEEGAFTGFMDAAGKSHTVSSAFLRPIWKPNVDFIKNPSL--NSQGFIITGN 307
Cdd:COG0492   181 ilVERLRANPKIEVLwNTEVTEIEgdgrVEGVTLKNVKTGEEKELEVDGVFVAIGLKPNTELLKGLGLelDEDGYIVVDE 260

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2156709089 308 DGRLNRGNMWAAGDVTG--IGQVSIAAGQGASVALDIGRYL 346
Cdd:COG0492   261 DMETSVPGVFAAGDVRDykYRQAATAAGEGAIAALSAARYL 301
TRX_reduct TIGR01292
thioredoxin-disulfide reductase; This model describes thioredoxin-disulfide reductase, a ...
 3-346 1.48e-14

thioredoxin-disulfide reductase; This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport]


Pssm-ID: 273540 [Multi-domain]  Cd Length: 299  Bit Score: 73.43  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPRNAATIAVH-----GViaREGISPHALRSDGGKALISFGGKILPSEV 77
Cdd:TIGR01292   1 DVIIIGAGPAGLTAAIYAARANLKPLLIEGMEPGGQLTTTTEvenypGF--PEGISGPELMEKMKEQAVKFGAEIIYEEV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  78 VSVVWTGDQSSVGLSpislsidgsvaepesccaasaisdmksnsssegagtegagtrkenqwyevdallhparNREKFLA 157
Cdd:TIGR01292  79 IKVDKSDRPFKVYTG----------------------------------------------------------DGKEYTA 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 158 KTVLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFDSVGLIGYGPDAvdiLQRAIYLS--------------FRV 223
Cdd:TIGR01292 101 KAVIIATGASARKLGIPGEDEFWGRGVSYCATCDGPFFKNKEVAVVGGGDSA---IEEALYLTriakkvtlvhrrdkFRA 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 224 SS-----------IVVFYNQFNQAQKG--ILENLGVKIVETQLTEVLLEEGAFTgfmdAAGkshtvssaflrpiWKPNVD 290
Cdd:TIGR01292 178 EKilldrlkknpkIEFLWNSTVEEIVGdnKVEGVKIKNTVTGEEEELEVDGVFI----AIG-------------HEPNTE 240

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2156709089 291 FIKNP-SLNSQGFIITGNDGRLNRGNMWAAGDVTGIG--QVSIAAGQGASVALDIGRYL 346
Cdd:TIGR01292 241 LLKGLlELDENGYIVTDEGMRTSVPGVFAAGDVRDKGyrQAVTAAGDGCIAALSAERYL 299
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-335 9.81e-08

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 53.09  E-value: 9.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPrnaatiavhgviaregisphalrsdggkalISFGGKILPSEVVSVVW 82
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGT------------------------------CPYGGCVLSKALLGAAE 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  83 TGDQSSVGlspislsidgsvaepesccaASAISDMKSNSSSEGAG----TEGAGTRKENQWYEVDALLHPARNREKFLAK 158
Cdd:pfam07992  52 APEIASLW--------------------ADLYKRKEEVVKKLNNGievlLGTEVVSIDPGAKKVVLEELVDGDGETITYD 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 159 TVLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFD--SVGLIGYGPDAVDIlqrAIYLSFRVSSIVVFYN----- 231
Cdd:pfam07992 112 RLVIATGARPRLPPIPGVELNVGFLVRTLDSAEALRLKLLpkRVVVVGGGYIGVEL---AAALAKLGKEVTLIEAldrll 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 232 -----QFNQAQKGILENLGVKIV-ETQLTE---------VLLEEG---AFTGFMDAAGKshtvssaflrpiwKPNVDFIK 293
Cdd:pfam07992 189 rafdeEISAALEKALEKNGVEVRlGTSVKEiigdgdgveVILKDGteiDADLVVVAIGR-------------RPNTELLE 255

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2156709089 294 NPSL--NSQGFIITGNDGRLNRGNMWAAGD--VTGIGQVSIAAGQG 335
Cdd:pfam07992 256 AAGLelDERGGIVVDEYLRTSVPGIYAAGDcrVGGPELAQNAVAQG 301
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 4-33 5.94e-07

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 50.95  E-value: 5.94e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:PRK11749  143 VAVIGAGPAGLTAAHRLARKGYDVTIFEAR 172
 
Name Accession Description Interval E-value
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-346 6.17e-31

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 119.45  E-value: 6.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRP--RNAATIAVHGVIA-REGISPHALRSDGGKALISFGGKILPSEVVS 79
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEPggQLATTKEIENYPGfPEGISGPELAERLREQAERFGAEILLEEVTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  80 VvwtgdqssvglspislsidgsvaepesccaasaisdmksnsssegagtegagtRKENQWYEVDAllhpaRNREKFLAKT 159
Cdd:COG0492    82 V-----------------------------------------------------DKDDGPFRVTT-----DDGTEYEAKA 103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 160 VLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFDSVGLIGYGPDAVDIlqrAIYLSFRVSS--IVVFYNQFNQA- 236
Cdd:COG0492   104 VIIATGAGPRKLGLPGEEEFEGRGVSYCATCDGFFFRGKDVVVVGGGDSALEE---ALYLTKFASKvtLIHRRDELRASk 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 237 --QKGILENLGVKIV-ETQLTEVL----LEEGAFTGFMDAAGKSHTVSSAFLRPIWKPNVDFIKNPSL--NSQGFIITGN 307
Cdd:COG0492   181 ilVERLRANPKIEVLwNTEVTEIEgdgrVEGVTLKNVKTGEEKELEVDGVFVAIGLKPNTELLKGLGLelDEDGYIVVDE 260

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2156709089 308 DGRLNRGNMWAAGDVTG--IGQVSIAAGQGASVALDIGRYL 346
Cdd:COG0492   261 DMETSVPGVFAAGDVRDykYRQAATAAGEGAIAALSAARYL 301
TRX_reduct TIGR01292
thioredoxin-disulfide reductase; This model describes thioredoxin-disulfide reductase, a ...
 3-346 1.48e-14

thioredoxin-disulfide reductase; This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport]


Pssm-ID: 273540 [Multi-domain]  Cd Length: 299  Bit Score: 73.43  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPRNAATIAVH-----GViaREGISPHALRSDGGKALISFGGKILPSEV 77
Cdd:TIGR01292   1 DVIIIGAGPAGLTAAIYAARANLKPLLIEGMEPGGQLTTTTEvenypGF--PEGISGPELMEKMKEQAVKFGAEIIYEEV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  78 VSVVWTGDQSSVGLSpislsidgsvaepesccaasaisdmksnsssegagtegagtrkenqwyevdallhparNREKFLA 157
Cdd:TIGR01292  79 IKVDKSDRPFKVYTG----------------------------------------------------------DGKEYTA 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 158 KTVLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFDSVGLIGYGPDAvdiLQRAIYLS--------------FRV 223
Cdd:TIGR01292 101 KAVIIATGASARKLGIPGEDEFWGRGVSYCATCDGPFFKNKEVAVVGGGDSA---IEEALYLTriakkvtlvhrrdkFRA 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 224 SS-----------IVVFYNQFNQAQKG--ILENLGVKIVETQLTEVLLEEGAFTgfmdAAGkshtvssaflrpiWKPNVD 290
Cdd:TIGR01292 178 EKilldrlkknpkIEFLWNSTVEEIVGdnKVEGVKIKNTVTGEEEELEVDGVFI----AIG-------------HEPNTE 240

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2156709089 291 FIKNP-SLNSQGFIITGNDGRLNRGNMWAAGDVTGIG--QVSIAAGQGASVALDIGRYL 346
Cdd:TIGR01292 241 LLKGLlELDENGYIVTDEGMRTSVPGVFAAGDVRDKGyrQAVTAAGDGCIAALSAERYL 299
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-33 1.62e-08

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 56.01  E-value: 1.62e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:COG1233     3 MYDVVVIGAGIGGLAAAALLARAGYRVTVLEKN 35
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-335 9.81e-08

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 53.09  E-value: 9.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPrnaatiavhgviaregisphalrsdggkalISFGGKILPSEVVSVVW 82
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGT------------------------------CPYGGCVLSKALLGAAE 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  83 TGDQSSVGlspislsidgsvaepesccaASAISDMKSNSSSEGAG----TEGAGTRKENQWYEVDALLHPARNREKFLAK 158
Cdd:pfam07992  52 APEIASLW--------------------ADLYKRKEEVVKKLNNGievlLGTEVVSIDPGAKKVVLEELVDGDGETITYD 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 159 TVLISSGVREVFPQIKNLRAVYGTNIHSCLSCDMWEKRFD--SVGLIGYGPDAVDIlqrAIYLSFRVSSIVVFYN----- 231
Cdd:pfam07992 112 RLVIATGARPRLPPIPGVELNVGFLVRTLDSAEALRLKLLpkRVVVVGGGYIGVEL---AAALAKLGKEVTLIEAldrll 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 232 -----QFNQAQKGILENLGVKIV-ETQLTE---------VLLEEG---AFTGFMDAAGKshtvssaflrpiwKPNVDFIK 293
Cdd:pfam07992 189 rafdeEISAALEKALEKNGVEVRlGTSVKEiigdgdgveVILKDGteiDADLVVVAIGR-------------RPNTELLE 255

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2156709089 294 NPSL--NSQGFIITGNDGRLNRGNMWAAGD--VTGIGQVSIAAGQG 335
Cdd:pfam07992 256 AAGLelDERGGIVVDEYLRTSVPGIYAAGDcrVGGPELAQNAVAQG 301
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-48 1.02e-07

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 53.37  E-value: 1.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPRNAATIAVHGVIA 48
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGASGRNAGQLR 49
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-58 2.40e-07

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 51.86  E-value: 2.40e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSnRPRNAATIAVHgviareGISPHALR 58
Cdd:COG0654     3 RTDVLIVGGGPAGLALALALARAGIRVTVVER-APPPRPDGRGI------ALSPRSLE 53
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 4-33 5.92e-07

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 50.90  E-value: 5.92e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:COG0493   124 VAVVGSGPAGLAAAYQLARAGHEVTVFEAL 153
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 4-33 5.94e-07

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 50.95  E-value: 5.94e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:PRK11749  143 VAVIGAGPAGLTAAHRLARKGYDVTIFEAR 172
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
3-58 1.60e-06

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 49.91  E-value: 1.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDsnrpRNAATI----AVH------GVIAREGISPHALR 58
Cdd:PRK06183   12 DVVIVGAGPVGLTLANLLGQYGVRVLVLE----RWPTLYdlprAVGiddealRVLQAIGLADEVLP 73
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 4-34 3.25e-06

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 48.72  E-value: 3.25e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:PRK12771  140 VAVIGGGPAGLSAAYHLRRMGHAVTIFEAGP 170
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 3-40 5.28e-06

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 47.97  E-value: 5.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPRNAAT 40
Cdd:TIGR01988   1 DIVIVGGGMVGLALALALARSGLKVALIEATPLPAPAD 38
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-68 1.02e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.90  E-value: 1.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2156709089   6 IIGGGPAGLTAGISLARMGWKVCVFDSnRPR---NAATIAVHGVIAREGisPHALRSDGGKALISF 68
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEK-RDRlggNAYSYRVPGYVFDYG--AHIFHGSDEPNVRDL 63
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-31 1.29e-05

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 46.41  E-value: 1.29e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:COG3380     3 MPDIAIIGAGIAGLAAARALQDAGHEVTVFE 33
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 5-34 1.31e-05

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 46.82  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   5 AIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNK 30
PRK13984 PRK13984
putative oxidoreductase; Provisional
 4-35 1.37e-05

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 47.07  E-value: 1.37e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDS-NRP 35
Cdd:PRK13984  286 VAIVGSGPAGLSAAYFLATMGYEVTVYESlSKP 318
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
3-31 1.48e-05

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 46.43  E-value: 1.48e-05
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK07494    9 DIAVIGGGPAGLAAAIALARAGASVALVA 37
COG2509 COG2509
FAD-dependent dehydrogenase [General function prediction only];
3-31 1.61e-05

FAD-dependent dehydrogenase [General function prediction only];


Pssm-ID: 441999 [Multi-domain]  Cd Length: 466  Bit Score: 46.64  E-value: 1.61e-05
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:COG2509    32 DVVIVGAGPAGLFAALELAEAGLKPLVLE 60
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 4-33 1.92e-05

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 46.65  E-value: 1.92e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:PRK12814  196 VAIIGAGPAGLTAAYYLLRKGHDVTIFDAN 225
PRK12831 PRK12831
putative oxidoreductase; Provisional
 4-31 2.29e-05

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 46.16  E-value: 2.29e-05
                          10        20
                  ....*....|....*....|....*...
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK12831  143 VAVIGSGPAGLTCAGDLAKMGYDVTIFE 170
HI0933_like pfam03486
HI0933-like protein;
3-34 2.72e-05

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 45.65  E-value: 2.72e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGK 33
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-74 2.73e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 45.98  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSNrPR---NAATIAVHGVI------------------ARE-GISPHALR 58
Cdd:COG1232     1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEAS-DRvggLIRTVEVDGFRidrgphsfltrdpevlelLRElGLGDELVW 79

                          90
                  ....*....|....*.
gi 2156709089  59 SDGGKALISFGGKILP 74
Cdd:COG1232    80 PNTRKSYIYYGGKLHP 95
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-34 2.80e-05

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 45.62  E-value: 2.80e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:COG2072     6 HVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKAD 39
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-33 2.86e-05

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 45.81  E-value: 2.86e-05
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   5 AIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKN 29
FAD_oxidored pfam12831
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ...
 3-34 4.12e-05

FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins.


Pssm-ID: 432816 [Multi-domain]  Cd Length: 420  Bit Score: 45.29  E-value: 4.12e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:pfam12831   1 DVVVVGGGPAGVAAAIAAARAGAKVLLVERRG 32
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 3-31 4.64e-05

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 45.22  E-value: 4.64e-05
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK01747  262 DAAIIGGGIAGAALALALARRGWQVTLYE 290
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 3-48 4.79e-05

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 45.21  E-value: 4.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPRNAATIAVHGVIA 48
Cdd:COG1053     5 DVVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHTAAAQGGIN 50
PRK06753 PRK06753
hypothetical protein; Provisional
 4-79 5.04e-05

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 44.68  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSNrprnaATIAVHGviAREGISPHAL----RSDGGKALISFGGKILPSEVVS 79
Cdd:PRK06753    3 IAIIGAGIGGLTAAALLQEQGHEVKVFEKN-----ESVKEVG--AGIGIGDNVIkklgNHDLAKGIKNAGQILSTMNLLD 75
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 3-34 5.06e-05

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 45.08  E-value: 5.06e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:COG1249     5 DLVVIGAGPGGYVAAIRAAQLGLKVALVEKGR 36
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 4-31 5.56e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 44.77  E-value: 5.56e-05
                          10        20
                  ....*....|....*....|....*...
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK12810  146 VAVVGSGPAGLAAADQLARAGHKVTVFE 173
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 3-48 7.48e-05

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 44.31  E-value: 7.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSN-RPRNAATIAVHGVIA 48
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGdDPGSGASGRNAGLIH 47
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
3-71 1.13e-04

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 43.76  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD-SNRP--RN--------------------AATIAVHGVIAREGISPHALRS 59
Cdd:COG1231     9 DVVIVGAGLAGLAAARELRKAGLDVTVLEaRDRVggRVwtlrfgddglyaelgamripPSHTNLLALARELGLPLEPFPN 88

                          90
                  ....*....|..
gi 2156709089  60 DGGKALISFGGK 71
Cdd:COG1231    89 ENGNALLYLGGK 100
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
9-58 1.60e-04

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 43.03  E-value: 1.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2156709089   9 GGPAGLTAGISLARMGWKVCVFDSNR-PRnaatiavhGVIAREGISPHALR 58
Cdd:COG0644     1 AGPAGSAAARRLARAGLSVLLLEKGSfPG--------DKICGGGLLPRALE 43
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 3-36 1.65e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 43.30  E-value: 1.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSnRPR 36
Cdd:COG3349     5 RVVVVGGGLAGLAAAVELAEAGFRVTLLEA-RPR 37
PRK07208 PRK07208
hypothetical protein; Provisional
 3-31 2.76e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 42.57  E-value: 2.76e-04
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK07208    6 SVVIIGAGPAGLTAAYELLKRGYPVTVLE 34
GlpB COG3075
Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];
3-27 3.13e-04

Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 442309  Cd Length: 415  Bit Score: 42.47  E-value: 3.13e-04
                          10        20
                  ....*....|....*....|....*
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKV 27
Cdd:COG3075     4 DVVVIGGGLAGLTAAIRAAEAGLRV 28
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 3-29 3.41e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 42.27  E-value: 3.41e-04
                          10        20
                  ....*....|....*....|....*..
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCV 29
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAV 27
PRK07538 PRK07538
hypothetical protein; Provisional
 3-58 3.63e-04

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 42.19  E-value: 3.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSnrprnAATIAVHGViareGIS--PHALR 58
Cdd:PRK07538    2 KVLIAGGGIGGLTLALTLHQRGIEVVVFEA-----APELRPLGV----GINllPHAVR 50
PRK06185 PRK06185
FAD-dependent oxidoreductase;
3-30 4.18e-04

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 42.15  E-value: 4.18e-04
                          10        20
                  ....*....|....*....|....*...
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVF 30
Cdd:PRK06185    8 DCCIVGGGPAGMMLGLLLARAGVDVTVL 35
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
3-27 4.74e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 42.15  E-value: 4.74e-04
                          10        20
                  ....*....|....*....|....*
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKV 27
Cdd:COG1148   142 RALVIGGGIAGMTAALELAEQGYEV 166
PRK05329 PRK05329
glycerol-3-phosphate dehydrogenase subunit GlpB;
1-27 5.39e-04

glycerol-3-phosphate dehydrogenase subunit GlpB;


Pssm-ID: 235412  Cd Length: 422  Bit Score: 41.76  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....*..
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKV 27
Cdd:PRK05329    2 KFDVLVIGGGLAGLTAALAAAEAGKRV 28
PLN02463 PLN02463
lycopene beta cyclase
 2-31 5.81e-04

lycopene beta cyclase


Pssm-ID: 178082 [Multi-domain]  Cd Length: 447  Bit Score: 41.62  E-value: 5.81e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   2 IDVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PLN02463   29 VDLVVVGGGPAGLAVAQQVSEAGLSVCCID 58
PRK07233 PRK07233
hypothetical protein; Provisional
 4-33 5.87e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 41.80  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:PRK07233    2 IAIVGGGIAGLAAAYRLAKRGHEVTVFEAD 31
carotene-cycl TIGR01790
lycopene cyclase family protein; This family includes lycopene beta and epsilion cyclases ...
 3-36 6.85e-04

lycopene cyclase family protein; This family includes lycopene beta and epsilion cyclases (which form beta and delta carotene, respectively) from bacteria and plants as well as the plant capsanthin/capsorubin and neoxanthin cyclases which appear to have evolved from the plant lycopene cyclases. The plant lycopene epsilon cyclases also transform neurosporene to alpha zeacarotene.


Pssm-ID: 130850 [Multi-domain]  Cd Length: 388  Bit Score: 41.26  E-value: 6.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPR 36
Cdd:TIGR01790   1 DLAVIGGGPAGLAIALELARPGLRVQLIEPHPPI 34
PRK09126 PRK09126
FAD-dependent hydroxylase;
3-31 7.35e-04

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 41.08  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK09126    5 DIVVVGAGPAGLSFARSLAGSGLKVTLIE 33
PRK12778 PRK12778
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ...
 2-32 7.42e-04

bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase;


Pssm-ID: 237200 [Multi-domain]  Cd Length: 752  Bit Score: 41.65  E-value: 7.42e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2156709089   2 IDVAIIGGGPAGLTAGISLARMGWKVCVFDS 32
Cdd:PRK12778  432 KKVAVIGSGPAGLSFAGDLAKRGYDVTVFEA 462
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
1-51 7.69e-04

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 41.28  E-value: 7.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLAR-MGWKVCVFD---------SNrpRNAATIavH-GVIAREG 51
Cdd:COG0579     4 MYDVVIIGAGIVGLALARELSRyEDLKVLVLEkeddvaqesSG--NNSGVI--HaGLYYTPG 61
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 3-31 7.86e-04

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 41.16  E-value: 7.86e-04
                          10        20
                  ....*....|....*....|....*....
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:pfam01494   3 DVLIVGGGPAGLMLALLLARAGVRVVLVE 31
PRK08401 PRK08401
L-aspartate oxidase; Provisional
 1-82 8.88e-04

L-aspartate oxidase; Provisional


Pssm-ID: 236259 [Multi-domain]  Cd Length: 466  Bit Score: 40.94  E-value: 8.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVF-----DSNRPRNAATIAVHGViarEGISPHALRSDGGKAlisfgGKILPS 75
Cdd:PRK08401    1 MMKVGIVGGGLAGLTAAISLAKKGFDVTIIgpgikKSNSYLAQAGIAFPIL---EGDSIRAHVLDTIRA-----GKYIND 72


                  ....*..
gi 2156709089  76 EvvSVVW 82
Cdd:PRK08401   73 E--EVVW 77
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 4-31 9.31e-04

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 40.74  E-value: 9.31e-04
                          10        20
                  ....*....|....*....|....*...
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK12770   21 VAIIGAGPAGLAAAGYLACLGYEVHVYD 48
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 3-345 9.57e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 40.93  E-value: 9.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPrnaatiavHGVIAREGISPhalrSdggKALISfggkilPSEVVSVVW 82
Cdd:PRK06292    5 DVIVIGAGPAGYVAARRAAKLGKKVALIEKGPL--------GGTCLNVGCIP----S---KALIA------AAEAFHEAK 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089  83 TGDQssVGLSPISLSIDGsvaepesccaASAISDMKSNSSSEGAGTEgAGTRKENqwyEVDALLHPAR---------NRE 153
Cdd:PRK06292   64 HAEE--FGIHADGPKIDF----------KKVMARVRRERDRFVGGVV-EGLEKKP---KIDKIKGTARfvdpntvevNGE 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 154 KFLAKTVLISSGVRevFPQIKNLRAVYGTNIhscLSCD---MWEKRFDSVGLIGYGPDAVDI---LQRaiyLSFRVsSIV 227
Cdd:PRK06292  128 RIEAKNIVIATGSR--VPPIPGVWLILGDRL---LTSDdafELDKLPKSLAVIGGGVIGLELgqaLSR---LGVKV-TVF 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 228 VFYNQF---------NQAQKgILE-----NLGVKIvetqlTEVLLEEGAFTGFMDAAGKSHTVSSAFL-----RpiwKPN 288
Cdd:PRK06292  199 ERGDRIlpledpevsKQAQK-ILSkefkiKLGAKV-----TSVEKSGDEKVEELEKGGKTETIEADYVlvatgR---RPN 269

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2156709089 289 VDFIK----NPSLNSQGFIITGNDGRLNRGNMWAAGDVTGIGQVS-IAAGQGASVALDIGRY 345
Cdd:PRK06292  270 TDGLGlentGIELDERGRPVVDEHTQTSVPGIYAAGDVNGKPPLLhEAADEGRIAAENAAGD 331
glycerol3P_GlpB TIGR03378
glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Members of this protein family are ...
 3-29 1.26e-03

glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Members of this protein family are the B subunit, product of the glpB gene, of a three-subunit, membrane-anchored, FAD-dependent anaerobic glycerol-3-phosphate dehydrogenase. [Energy metabolism, Anaerobic]


Pssm-ID: 213807  Cd Length: 419  Bit Score: 40.39  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....*..
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCV 29
Cdd:TIGR03378   2 DVIIIGGGLAGLSCALRLAEAGKKCAI 28
PRK06184 PRK06184
hypothetical protein; Provisional
 1-24 1.94e-03

hypothetical protein; Provisional


Pssm-ID: 235728 [Multi-domain]  Cd Length: 502  Bit Score: 39.97  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|....
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMG 24
Cdd:PRK06184    3 TTDVLIVGAGPTGLTLAIELARRG 26
PTZ00052 PTZ00052
thioredoxin reductase; Provisional
 1-40 2.14e-03

thioredoxin reductase; Provisional


Pssm-ID: 185416 [Multi-domain]  Cd Length: 499  Bit Score: 39.81  E-value: 2.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSNRPRNAAT 40
Cdd:PTZ00052    5 MYDLVVIGGGSGGMAAAKEAAAHGKKVALFDYVKPSTQGT 44
PRK12775 PRK12775
putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin ...
 4-86 2.84e-03

putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional


Pssm-ID: 183738 [Multi-domain]  Cd Length: 1006  Bit Score: 39.92  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089    4 VAIIGGGPAGLTAGISLARMGWKVCVFDSnrprnaatIAVHGVIAREGISPHALRSD----GGKALISFGGKILPSEVVS 79
Cdd:PRK12775   433 VAICGSGPAGLAAAADLVKYGVDVTVYEA--------LHVVGGVLQYGIPSFRLPRDiidrEVQRLVDIGVKIETNKVIG 504


                   ....*..
gi 2156709089   80 VVWTGDQ 86
Cdd:PRK12775   505 KTFTVPQ 511
PRK08132 PRK08132
FAD-dependent oxidoreductase; Provisional
 4-33 3.14e-03

FAD-dependent oxidoreductase; Provisional


Pssm-ID: 236158 [Multi-domain]  Cd Length: 547  Bit Score: 39.47  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFDSN 33
Cdd:PRK08132   26 VVVVGAGPVGLALAIDLAQQGVPVVLLDDD 55
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
3-70 4.05e-03

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 39.01  E-value: 4.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVFDsnrprnaatiavhgviaREGisPHALrsdGGKALISFGG 70
Cdd:COG3573     7 DVIVVGAGLAGLVAAAELADAGRRVLLLD-----------------QEP--EANL---GGQAFWSFGG 52
Thi4 pfam01946
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
 3-32 4.84e-03

Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.


Pssm-ID: 460393  Cd Length: 232  Bit Score: 38.22  E-value: 4.84e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2156709089   3 DVAIIGGGPAGLTAGISLAR-MGWKVCVFDS 32
Cdd:pfam01946  19 DVVIVGAGSSGLTAAYYLAKnRGLKVAIIER 49
PRK15317 PRK15317
alkyl hydroperoxide reductase subunit F; Provisional
 248-340 5.36e-03

alkyl hydroperoxide reductase subunit F; Provisional


Pssm-ID: 237942 [Multi-domain]  Cd Length: 517  Bit Score: 38.60  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2156709089 248 IVETQLTEVLLEEGAFTG--FMD-AAGKSHTVSSA--FLRPIWKPNVDFIKNP-SLNSQGFIITGNDGRLNRGNMWAAGD 321
Cdd:PRK15317  405 ITNAQTTEVTGDGDKVTGltYKDrTTGEEHHLELEgvFVQIGLVPNTEWLKGTvELNRRGEIIVDARGATSVPGVFAAGD 484

                          90       100
                  ....*....|....*....|.
gi 2156709089 322 VTGI--GQVSIAAGQGASVAL 340
Cdd:PRK15317  485 CTTVpyKQIIIAMGEGAKAAL 505
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 4-31 6.52e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 38.57  E-value: 6.52e-03
                          10        20
                  ....*....|....*....|....*...
gi 2156709089   4 VAIIGGGPAGLTAGISLARMGWKVCVFD 31
Cdd:PRK12769  330 VAIIGAGPAGLACADVLARNGVAVTVYD 357
GIDA pfam01134
Glucose inhibited division protein A;
3-30 6.79e-03

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 38.30  E-value: 6.79e-03
                          10        20
                  ....*....|....*....|....*...
gi 2156709089   3 DVAIIGGGPAGLTAGISLARMGWKVCVF 30
Cdd:pfam01134   1 DVIVIGGGHAGCEAALAAARMGAKVLLI 28
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 1-34 7.93e-03

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 38.08  E-value: 7.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2156709089   1 MIDVAIIGGGPAGLTAGISLARMGWKVCVFDSNR 34
Cdd:PRK12409    1 MSHIAVIGAGITGVTTAYALAQRGYQVTVFDRHR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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