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Conserved domains on  [gi|2153801143|ref|WP_229210411|]
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hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Duganella sp. CF517]

Protein Classification

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase( domain architecture ID 10001245)

bifunctional enzyme, phosphomethylpyrimidine (HMP-P) kinase/hydroxymethylpyrimidine (HMP) kinase; bifunctional hydroxymethylpyrimidine (HMP) kinase/phosphomethylpyrimidine (HMP-P) kinase catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P

CATH:  3.40.1190.20
EC:  2.7.4.7|2.7.1.49
Gene Symbol:  thiD
Gene Ontology:  GO:0005524|GO:0016310|GO:0042724|GO:0008902|GO:0008972|GO:0009228|GO:0005829
PubMed:  8382990|11839308
SCOP:  3001268

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 16-270 2.06e-79

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


:

Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 240.33  E-value: 2.06e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  16 LVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAAN 95
Cdd:COG0351     1 LTIAGSDPSGGAGIQADLKTFAALGVYGMSVITALTAQNTLGVTGVHPVPPEFVAAQLRAVLEDIPVDAIKIGMLGSAEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  96 ALAIARVIRalreRQPELPVVLDPVLASGHGDTLSRGDAVAAL-APLLPLVTVLTPNGPEALALSAHTTPN-----AQAR 169
Cdd:COG0351    81 IEAVAEILA----DYPLVPVVLDPVMVAKSGDRLLDEDAVEALrELLLPLATVVTPNLPEAEALLGIEITTlddmrEAAK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 170 ALRALGCRHVLITGGHGDGDEIVNRWFGPGaeagagsgrppATQQWRWQRLDGG-FHGSGCTLASAIAGQLALGMPTGCA 248
Cdd:COG0351   157 ALLELGAKAVLVKGGHLPGDEAVDVLYDGD-----------GVREFSAPRIDTGnTHGTGCTLSSAIAALLAKGLDLEEA 225

                         250       260
                  ....*....|....*....|..
gi 2153801143 249 LDQAQYYCNAALRDAYGIAAGQ 270
Cdd:COG0351   226 VREAKEYVTQAIRAALRLGMGH 247
 
Name Accession Description Interval E-value
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 16-270 2.06e-79

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 240.33  E-value: 2.06e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  16 LVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAAN 95
Cdd:COG0351     1 LTIAGSDPSGGAGIQADLKTFAALGVYGMSVITALTAQNTLGVTGVHPVPPEFVAAQLRAVLEDIPVDAIKIGMLGSAEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  96 ALAIARVIRalreRQPELPVVLDPVLASGHGDTLSRGDAVAAL-APLLPLVTVLTPNGPEALALSAHTTPN-----AQAR 169
Cdd:COG0351    81 IEAVAEILA----DYPLVPVVLDPVMVAKSGDRLLDEDAVEALrELLLPLATVVTPNLPEAEALLGIEITTlddmrEAAK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 170 ALRALGCRHVLITGGHGDGDEIVNRWFGPGaeagagsgrppATQQWRWQRLDGG-FHGSGCTLASAIAGQLALGMPTGCA 248
Cdd:COG0351   157 ALLELGAKAVLVKGGHLPGDEAVDVLYDGD-----------GVREFSAPRIDTGnTHGTGCTLSSAIAALLAKGLDLEEA 225

                         250       260
                  ....*....|....*....|..
gi 2153801143 249 LDQAQYYCNAALRDAYGIAAGQ 270
Cdd:COG0351   226 VREAKEYVTQAIRAALRLGMGH 247
HMPP_kinase cd01169
4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two ...
 14-263 6.69e-75

4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.


Pssm-ID: 238574 [Multi-domain]  Cd Length: 242  Bit Score: 228.54  E-value: 6.69e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  14 CVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSA 93
Cdd:cd01169     1 VVLTIAGSDSSGGAGIQADLKTFAALGVYGMSVITALTAQNTLGVFGVHPVPPEFVAAQLDAVLEDIPVDAIKIGMLGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  94 ANALAIARVIRALrerqPELPVVLDPVLASGHGDTLSRGDAVAALA-PLLPLVTVLTPNGPEALALSAHTTPN-----AQ 167
Cdd:cd01169    81 EIIEAVAEALKDY----PDIPVVLDPVMVAKSGDSLLDDDAIEALReLLLPLATLITPNLPEAELLTGLEIATeedmmKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 168 ARALRALGCRHVLITGGHGDGDEIVNRWFGPGAEagagsgrppaTQQWRWQRLDGGFHGSGCTLASAIAGQLALGMPTGC 247
Cdd:cd01169   157 AKALLALGAKAVLIKGGHLPGDEAVDVLYDGGGF----------FEFESPRIDTKNTHGTGCTLSSAIAANLAKGLSLEE 226

                         250
                  ....*....|....*.
gi 2153801143 248 ALDQAQYYCNAALRDA 263
Cdd:cd01169   227 AVREAKEYVTQAIRNA 242
Phos_pyr_kin pfam08543
Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate ...
 22-269 2.82e-67

Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.


Pssm-ID: 430062 [Multi-domain]  Cd Length: 246  Bit Score: 209.26  E-value: 2.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  22 DPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAANALAIAR 101
Cdd:pfam08543   1 DSSGGAGIQADLKTFSALGVYGMSVITALTAQNTLGVQGVHPLPPEFVAAQLDAVLEDIPVDAVKTGMLGSAEIIEAVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 102 VIralreRQPELPVVLDPVLASGHGDTLSRGDAVAALAP-LLPLVTVLTPNGPEALALS---AHTTPNA--QARALRALG 175
Cdd:pfam08543  81 KL-----DKYGVPVVLDPVMVAKSGDSLLDDEAIEALKEeLLPLATLITPNLPEAEALTgrkIKTLEDMkeAAKKLLALG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 176 CRHVLITGGHGDGDE--IVNRWFGPGAEagagsgrppatQQWRWQRLDGGF-HGSGCTLASAIAGQLALGMPTGCALDQA 252
Cdd:pfam08543 156 AKAVLIKGGHLEGEEavVTDVLYDGGGF-----------YTLEAPRIPTKNtHGTGCTLSAAIAANLAKGLSLPEAVREA 224

                         250
                  ....*....|....*..
gi 2153801143 253 QYYCNAALRDAYGIAAG 269
Cdd:pfam08543 225 KEYVTEAIRDALNLGKG 241
PRK06427 PRK06427
bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
 12-270 3.26e-65

bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed


Pssm-ID: 180561 [Multi-domain]  Cd Length: 266  Bit Score: 204.59  E-value: 3.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  12 RPCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPG 91
Cdd:PRK06427    4 RPIALTIAGSDSGGGAGIQADLKTFQALGVYGMSAITALTAQNTLGVQRVHPIPPEFVAAQLDAVFSDIRIDAVKIGMLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  92 SAANALAIARVIRalreRQPELPVVLDPVLASGHGDTLSRGDAVAAL-APLLPLVTVLTPNGPEALALS------AHTTP 164
Cdd:PRK06427   84 SAEIIETVAEALK----RYPIPPVVLDPVMIAKSGDPLLADDAVAALrERLLPLATLITPNLPEAEALTglpiadTEDEM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 165 NAQARALRALGCRHVLITGGH-GDGDEIVNRWFGPGAEagagsgrppatQQWRWQRLDGG-FHGSGCTLASAIAGQLALG 242
Cdd:PRK06427  160 KAAARALHALGCKAVLIKGGHlLDGEESVDWLFDGEGE-----------ERFSAPRIPTKnTHGTGCTLSAAIAAELAKG 228

                         250       260
                  ....*....|....*....|....*...
gi 2153801143 243 MPTGCALDQAQYYCNAALRDAYGIAAGQ 270
Cdd:PRK06427  229 ASLLDAVQTAKDYVTRAIRHALEIGQGH 256
HMP-P_kinase TIGR00097
hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a ...
 15-270 6.31e-49

hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a bifunctional enzyme, phosphomethylpyrimidine kinase (EC 2.7.4.7)/Hydroxymethylpyrimidine kinase (EC 2.7.1.49), the ThiD/J protein of thiamine biosynthesis. The protein is commonly observed within operons containing other thiamine biosynthesis genes. Numerous examples are fusion proteins with other thiamine-biosynthetic domains. Saccaromyces has three recent paralogs, two of which are isofunctional and score above the trusted cutoff. The third shows a longer branch length in a phylogenetic tree and scores below the trusted cutoff, as do putative second copies in a number of species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 272904 [Multi-domain]  Cd Length: 254  Bit Score: 162.46  E-value: 6.31e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  15 VLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAA 94
Cdd:TIGR00097   1 ALTIAGSDSGGGAGIQADLKTFSALGVFGTSVITALTAQNTRGVTGVYPIPPDFVEAQLDAVFSDIPVDAAKTGMLASAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  95 nalAIARVIRALRERQPElPVVLDPVLASGHGDTLSRGDAVAALAP-LLPLVTVLTPNGPEALALSAHTTPNAQ-----A 168
Cdd:TIGR00097  81 ---IVEAVARKLREYPVR-PLVVDPVMVAKSGAPLLEEEAIEALRKrLLPLATLITPNLPEAEALLGTKIRTEQdmikaA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 169 RALRALGCRHVLITGGHGDGDEIVNRWFGPGAEagagsgrppatQQWRWQRLDG-GFHGSGCTLASAIAGQLALGMPTGC 247
Cdd:TIGR00097 157 KKLRELGPKAVLIKGGHLEGDQAVDVLFDGGEI-----------HILKAPRIETkNTHGTGCTLSAAIAANLAKGLSLKE 225

                         250       260
                  ....*....|....*....|...
gi 2153801143 248 ALDQAQYYCNAALRDAYGIAAGQ 270
Cdd:TIGR00097 226 AVKEAKEFVTGAIRYGLNIGHGH 248
 
Name Accession Description Interval E-value
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 16-270 2.06e-79

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 240.33  E-value: 2.06e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  16 LVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAAN 95
Cdd:COG0351     1 LTIAGSDPSGGAGIQADLKTFAALGVYGMSVITALTAQNTLGVTGVHPVPPEFVAAQLRAVLEDIPVDAIKIGMLGSAEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  96 ALAIARVIRalreRQPELPVVLDPVLASGHGDTLSRGDAVAAL-APLLPLVTVLTPNGPEALALSAHTTPN-----AQAR 169
Cdd:COG0351    81 IEAVAEILA----DYPLVPVVLDPVMVAKSGDRLLDEDAVEALrELLLPLATVVTPNLPEAEALLGIEITTlddmrEAAK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 170 ALRALGCRHVLITGGHGDGDEIVNRWFGPGaeagagsgrppATQQWRWQRLDGG-FHGSGCTLASAIAGQLALGMPTGCA 248
Cdd:COG0351   157 ALLELGAKAVLVKGGHLPGDEAVDVLYDGD-----------GVREFSAPRIDTGnTHGTGCTLSSAIAALLAKGLDLEEA 225

                         250       260
                  ....*....|....*....|..
gi 2153801143 249 LDQAQYYCNAALRDAYGIAAGQ 270
Cdd:COG0351   226 VREAKEYVTQAIRAALRLGMGH 247
HMPP_kinase cd01169
4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two ...
 14-263 6.69e-75

4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.


Pssm-ID: 238574 [Multi-domain]  Cd Length: 242  Bit Score: 228.54  E-value: 6.69e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  14 CVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSA 93
Cdd:cd01169     1 VVLTIAGSDSSGGAGIQADLKTFAALGVYGMSVITALTAQNTLGVFGVHPVPPEFVAAQLDAVLEDIPVDAIKIGMLGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  94 ANALAIARVIRALrerqPELPVVLDPVLASGHGDTLSRGDAVAALA-PLLPLVTVLTPNGPEALALSAHTTPN-----AQ 167
Cdd:cd01169    81 EIIEAVAEALKDY----PDIPVVLDPVMVAKSGDSLLDDDAIEALReLLLPLATLITPNLPEAELLTGLEIATeedmmKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 168 ARALRALGCRHVLITGGHGDGDEIVNRWFGPGAEagagsgrppaTQQWRWQRLDGGFHGSGCTLASAIAGQLALGMPTGC 247
Cdd:cd01169   157 AKALLALGAKAVLIKGGHLPGDEAVDVLYDGGGF----------FEFESPRIDTKNTHGTGCTLSSAIAANLAKGLSLEE 226

                         250
                  ....*....|....*.
gi 2153801143 248 ALDQAQYYCNAALRDA 263
Cdd:cd01169   227 AVREAKEYVTQAIRNA 242
Phos_pyr_kin pfam08543
Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate ...
 22-269 2.82e-67

Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.


Pssm-ID: 430062 [Multi-domain]  Cd Length: 246  Bit Score: 209.26  E-value: 2.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  22 DPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAANALAIAR 101
Cdd:pfam08543   1 DSSGGAGIQADLKTFSALGVYGMSVITALTAQNTLGVQGVHPLPPEFVAAQLDAVLEDIPVDAVKTGMLGSAEIIEAVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 102 VIralreRQPELPVVLDPVLASGHGDTLSRGDAVAALAP-LLPLVTVLTPNGPEALALS---AHTTPNA--QARALRALG 175
Cdd:pfam08543  81 KL-----DKYGVPVVLDPVMVAKSGDSLLDDEAIEALKEeLLPLATLITPNLPEAEALTgrkIKTLEDMkeAAKKLLALG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 176 CRHVLITGGHGDGDE--IVNRWFGPGAEagagsgrppatQQWRWQRLDGGF-HGSGCTLASAIAGQLALGMPTGCALDQA 252
Cdd:pfam08543 156 AKAVLIKGGHLEGEEavVTDVLYDGGGF-----------YTLEAPRIPTKNtHGTGCTLSAAIAANLAKGLSLPEAVREA 224

                         250
                  ....*....|....*..
gi 2153801143 253 QYYCNAALRDAYGIAAG 269
Cdd:pfam08543 225 KEYVTEAIRDALNLGKG 241
PRK06427 PRK06427
bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
 12-270 3.26e-65

bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed


Pssm-ID: 180561 [Multi-domain]  Cd Length: 266  Bit Score: 204.59  E-value: 3.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  12 RPCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPG 91
Cdd:PRK06427    4 RPIALTIAGSDSGGGAGIQADLKTFQALGVYGMSAITALTAQNTLGVQRVHPIPPEFVAAQLDAVFSDIRIDAVKIGMLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  92 SAANALAIARVIRalreRQPELPVVLDPVLASGHGDTLSRGDAVAAL-APLLPLVTVLTPNGPEALALS------AHTTP 164
Cdd:PRK06427   84 SAEIIETVAEALK----RYPIPPVVLDPVMIAKSGDPLLADDAVAALrERLLPLATLITPNLPEAEALTglpiadTEDEM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 165 NAQARALRALGCRHVLITGGH-GDGDEIVNRWFGPGAEagagsgrppatQQWRWQRLDGG-FHGSGCTLASAIAGQLALG 242
Cdd:PRK06427  160 KAAARALHALGCKAVLIKGGHlLDGEESVDWLFDGEGE-----------ERFSAPRIPTKnTHGTGCTLSAAIAAELAKG 228

                         250       260
                  ....*....|....*....|....*...
gi 2153801143 243 MPTGCALDQAQYYCNAALRDAYGIAAGQ 270
Cdd:PRK06427  229 ASLLDAVQTAKDYVTRAIRHALEIGQGH 256
HMP-P_kinase TIGR00097
hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a ...
 15-270 6.31e-49

hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a bifunctional enzyme, phosphomethylpyrimidine kinase (EC 2.7.4.7)/Hydroxymethylpyrimidine kinase (EC 2.7.1.49), the ThiD/J protein of thiamine biosynthesis. The protein is commonly observed within operons containing other thiamine biosynthesis genes. Numerous examples are fusion proteins with other thiamine-biosynthetic domains. Saccaromyces has three recent paralogs, two of which are isofunctional and score above the trusted cutoff. The third shows a longer branch length in a phylogenetic tree and scores below the trusted cutoff, as do putative second copies in a number of species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 272904 [Multi-domain]  Cd Length: 254  Bit Score: 162.46  E-value: 6.31e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  15 VLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGSAA 94
Cdd:TIGR00097   1 ALTIAGSDSGGGAGIQADLKTFSALGVFGTSVITALTAQNTRGVTGVYPIPPDFVEAQLDAVFSDIPVDAAKTGMLASAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  95 nalAIARVIRALRERQPElPVVLDPVLASGHGDTLSRGDAVAALAP-LLPLVTVLTPNGPEALALSAHTTPNAQ-----A 168
Cdd:TIGR00097  81 ---IVEAVARKLREYPVR-PLVVDPVMVAKSGAPLLEEEAIEALRKrLLPLATLITPNLPEAEALLGTKIRTEQdmikaA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 169 RALRALGCRHVLITGGHGDGDEIVNRWFGPGAEagagsgrppatQQWRWQRLDG-GFHGSGCTLASAIAGQLALGMPTGC 247
Cdd:TIGR00097 157 KKLRELGPKAVLIKGGHLEGDQAVDVLFDGGEI-----------HILKAPRIETkNTHGTGCTLSAAIAANLAKGLSLKE 225

                         250       260
                  ....*....|....*....|...
gi 2153801143 248 ALDQAQYYCNAALRDAYGIAAGQ 270
Cdd:TIGR00097 226 AVKEAKEFVTGAIRYGLNIGHGH 248
PLN02898 PLN02898
HMP-P kinase/thiamin-monophosphate pyrophosphorylase
 8-269 1.26e-39

HMP-P kinase/thiamin-monophosphate pyrophosphorylase


Pssm-ID: 215486 [Multi-domain]  Cd Length: 502  Bit Score: 143.76  E-value: 1.26e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143   8 GPAARPCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKI 87
Cdd:PLN02898    5 SPMKVPHVLTVAGSDSGAGAGIQADIKACAARGVYCTTAITAVTAQNTVGVQGVHAVPLDFVAEQLKSVLSDMPVDVVKT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  88 GIpgsaanaLAIARVIRALRERQPELPV---VLDPVLASGHGDTLSRGDAVAAL-APLLPLVTVLTPNGPEALAL----S 159
Cdd:PLN02898   85 GM-------LPSAEIVKVLCQALKEFPVkalVVDPVMVSTSGDVLAGPSILSALrEELLPLATIVTPNVKEASALlggdP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 160 AHTTPN--AQARALRALGCRHVLITGGH-GDGDEIVNRWFGpgaeagaGSGrppaTQQWRWQRLDG-GFHGSGCTLASAI 235
Cdd:PLN02898  158 LETVADmrSAAKELHKLGPRYVLVKGGHlPDSLDAVDVLYD-------GTE----FHELRSSRIKTrNTHGTGCTLASCI 226

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2153801143 236 AGQLALGMPTGCALDQAQYYCNAALRDAYGIAAG 269
Cdd:PLN02898  227 AAELAKGSDMLSAVKVAKRYVETALEYSKDIGIG 260
PRK14713 PRK14713
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
4-270 1.36e-37

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 237797 [Multi-domain]  Cd Length: 530  Bit Score: 138.77  E-value: 1.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143   4 DVAPGPAARPCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQdNDRAYEVQPVEPALVLR-QARALTDKIAV 82
Cdd:PRK14713   21 AAAASAAATPRVLSIAGTDPSGGAGIQADLKSIAAAGGYGMAVITALVAQ-NTRGVRAVHVPPADFLRaQLDAVSDDVTV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  83 AAVKIGIPGSAANalaIARVIRALRERQPELpVVLDPVLASGHGDTLSRGDAVAALAPLLPLVTVLTPNGPEALALS--- 159
Cdd:PRK14713  100 DAVKIGMLGDAEV---IDAVRTWLAEHRPPV-VVLDPVMVATSGDRLLEEDAEAALRELVPRADLITPNLPELAVLLgep 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 160 AHTTPN---AQARALRALGCRHVLITGGHGDGDEIVNRWFGP-GAEAGAGSGRPPATQQwrwqrldggfHGSGCTLASAI 235
Cdd:PRK14713  176 PATTWEealAQARRLAAETGTTVLVKGGHLDGQRAPDALVGPdGAVTEVPGPRVDTRNT----------HGTGCSLSSAL 245

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2153801143 236 AGQLALGMPTGCALDQAQYYCNAALRDAYGIAAGQ 270
Cdd:PRK14713  246 ATRLGRGGDWAAALRWATAWLHGAIAAGAALQVGT 280
PTZ00347 PTZ00347
phosphomethylpyrimidine kinase; Provisional
 8-270 5.86e-34

phosphomethylpyrimidine kinase; Provisional


Pssm-ID: 240375 [Multi-domain]  Cd Length: 504  Bit Score: 128.54  E-value: 5.86e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143   8 GPAARPCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKI 87
Cdd:PTZ00347  226 NPMKIPTVLTVSGSDSGGGAGHQADLKTLEALGVYSTSALTSLTAQNTKGVQQIQVVNEDFFAAQIDSVMSDFNISVVKL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  88 GIpgsaanaLAIARVIRALRERQPELPVVLDPVLASGHGDTLSRGDAVAAL-----APLLPLVTVLTPNGPEA---LALS 159
Cdd:PTZ00347  306 GL-------VPTARQLEIVIEKLKNLPMVVDPVLVATSGDDLVAQKNADDVlamykERIFPMATIITPNIPEAeriLGRK 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 160 AHTT---PNAQARALRALGCRHVLITGGHGDGDEIVNRWFGPGAEAGagsgrppatqqwRWQRLDGGF------HGSGCT 230
Cdd:PTZ00347  379 EITGvyeARAAAQALAQYGSRYVLVKGGHDLIDPEACRDVLYDREKD------------RFYEFTANRiatintHGTGCT 446

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2153801143 231 LASAIAGQLALGMPTGCALDQAQYYCNAALRDAYGIAAGQ 270
Cdd:PTZ00347  447 LASAISSFLARGYTVPDAVERAIGYVHEAIVRSCGVPLGQ 486
PRK08573 PRK08573
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
13-269 8.18e-32

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 236297 [Multi-domain]  Cd Length: 448  Bit Score: 121.76  E-value: 8.18e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  13 PCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGS 92
Cdd:PRK08573    3 PVALTIAGSDSGGGAGIEADLKTFAALGVHGAVAITSVTAQNTYEVRAIHDLPPEVVAAQIEAVWEDMGIDAAKTGMLSN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  93 AANALAIARVIRALrerqpELPVVLDPVLASGHGDTLSRGDAVAALAP-LLPLVTVLTPNGPEALAL------SAHTTPN 165
Cdd:PRK08573   83 REIIEAVAKTVSKY-----GFPLVVDPVMIAKSGAPLLREDAVDALIKrLLPLATVVTPNRPEAEKLtgmkirSVEDARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 166 AQARALRALGCRHVLITGGHGDGDEIVNRWFGPGaeagagsgrppATQQWRWQRLDGG-FHGSGCTLASAIAGQLALGMP 244
Cdd:PRK08573  158 AAKYIVEELGAEAVVVKGGHLEGEEAVDVLYHNG-----------TFREFRAPRVESGcTHGTGCSFSAAIAAGLAKGLD 226

                         250       260
                  ....*....|....*....|....*
gi 2153801143 245 TGCALDQAQYYCNAALRdaYGIAAG 269
Cdd:PRK08573  227 PEEAIKTAKKFITMAIK--YGVKIG 249
PRK09517 PRK09517
multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; ...
 2-269 2.49e-30

multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional


Pssm-ID: 169939 [Multi-domain]  Cd Length: 755  Bit Score: 119.69  E-value: 2.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143   2 APDVAPGPAARPCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIA 81
Cdd:PRK09517  231 LQGAFVNSPSAPRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTALVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVT 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  82 VAAVKIGIPGSAANALAIARVIRALRERqpelPVVLDPVLASGHGDTLSRGDAVAALAPLLPLVTVLTPNGPEALALSAH 161
Cdd:PRK09517  311 VDAVKLGMLGSADTVDLVASWLGSHEHG----PVVLDPVMVATSGDRLLDADATEALRRLAVHVDVVTPNIPELAVLCGE 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 162 TTPNAQARAL---RALGCRH---VLITGGHGDGDEIVNRWFGPGAEAGAGSGRPPATQQwrwqrldggFHGSGCTLASAI 235
Cdd:PRK09517  387 APAITMDEAIaqaRGFARTHgtiVIVKGGHLTGDLADNAVVRPDGSVHQVENPRVNTTN---------SHGTGCSLSAAL 457

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2153801143 236 AGQLALGMPTGCALDQAQYYCNAALRDAYGIAAG 269
Cdd:PRK09517  458 ATLIAAGESVEKALEWATRWLNEALRHADHLAVG 491
PRK12413 PRK12413
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
15-266 4.58e-28

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183513 [Multi-domain]  Cd Length: 253  Bit Score: 108.23  E-value: 4.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  15 VLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDnDRAYEVQPVEPALVLRQARALTDkIAVAAVKIGIPGSAA 94
Cdd:PRK12413    6 ILAISGNDIFSGGGLHADLATYTRNGLHGFVAVTCLTAMT-EKGFEVFPVDKEIFQQQLDSLKD-VPFSAIKIGLLPNVE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  95 nalaIARVIRALRERQPELPVVLDPVLASGHGDTLSRGDAVAALAPLLPLVTVLTPNGPEALALSAHTTPN-----AQAR 169
Cdd:PRK12413   84 ----IAEQALDFIKGHPGIPVVLDPVLVCKETHDVEVSELRQELIQFFPYVTVITPNLVEAELLSGKEIKTledmkEAAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 170 ALRALGCRHVLITGGhgdgdeivNRWFGPGAEAGAGSGRppATQQWRWQRLDGGFHGSGCTLASAIAGQLALGMPTGCAL 249
Cdd:PRK12413  160 KLYDLGAKAVVIKGG--------NRLSQKKAIDLFYDGK--EFVILESPVLEKNNIGAGCTFASSIASQLVKGKSPLEAV 229

                         250
                  ....*....|....*....
gi 2153801143 250 DQAQYYCNAALR--DAYGI 266
Cdd:PRK12413  230 KNSKDFVYQAIQqsDQYGV 248
PRK12616 PRK12616
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
16-264 4.30e-22

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183624  Cd Length: 270  Bit Score: 92.42  E-value: 4.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  16 LVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQD--NDRAYEVQPVEPALVLRQARALTDKIAVAAVKIG-IPGS 92
Cdd:PRK12616    7 LTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVVVAMDpeNSWDHQVFPIDTDTIRAQLSTIVDGIGVDAMKTGmLPTV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  93 AANALAiARVIRALRERQpelpVVLDPVLA-SGHGDTLSRGDAVAALAPLLPLVTVLTPNGPEALALSA----HTTPNAQ 167
Cdd:PRK12616   87 DIIELA-ADTIKEKQLKN----VVIDPVMVcKGANEVLYPEHAEALREQLAPLATVITPNLFEAGQLSGmgeiKTVEQMK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 168 --ARALRALGCRHVLITGGHG-DGDEIVNRWF-GPGAEAGAGsgrppatqqwrwQRLDGGF-HGSGCTLASAIAGQLALG 242
Cdd:PRK12616  162 eaAKKIHELGAQYVVITGGGKlKHEKAVDVLYdGETAEVLES------------EMIDTPYtHGAGCTFSAAVTAELAKG 229

                         250       260
                  ....*....|....*....|..
gi 2153801143 243 MPTGCALDQAQYYCNAALRDAY 264
Cdd:PRK12616  230 SEVKEAIYAAKEFITAAIKESF 251
PRK12412 PRK12412
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
13-266 3.89e-21

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183512 [Multi-domain]  Cd Length: 268  Bit Score: 90.03  E-value: 3.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  13 PCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQD--NDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIP 90
Cdd:PRK12412    2 NKALTIAGSDTSGGAGIQADLKTFQELGVYGMTSLTTIVTMDphNGWAHNVFPIPASTLKPQLETTIEGVGVDALKTGML 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  91 GSAANALAIARVIralrERQPELPVVLDPVLA-SGHGDTLSRGDAVAALAPLLPLVTVLTPNGPEALALSA---HTTPNA 166
Cdd:PRK12412   82 GSVEIIEMVAETI----EKHNFKNVVVDPVMVcKGADEALHPETNDCLRDVLVPKALVVTPNLFEAYQLSGvkiNSLEDM 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 167 QARALR--ALGCRHVLITGGHGDGDEIVNRWFGPGAeagagsgrppATQQWRWQRLDGGF-HGSGCTLASAIAGQLALGM 243
Cdd:PRK12412  158 KEAAKKihALGAKYVLIKGGSKLGTETAIDVLYDGE----------TFDLLESEKIDTTNtHGAGCTYSAAITAELAKGK 227

                         250       260
                  ....*....|....*....|...
gi 2153801143 244 PTGCALDQAQYYCNAALRDAYGI 266
Cdd:PRK12412  228 PVKEAVKTAKEFITAAIRYSFKI 250
pyridoxal_pyridoxamine_kinase cd01173
Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5 ...
 69-261 1.89e-15

Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and require its precursors in the form of vitamin B6 (pyridoxal, pyridoxine, and pyridoxamine) from their diet. Pyridoxal kinase encoding genes are also found in many other species including yeast and bacteria.


Pssm-ID: 238578 [Multi-domain]  Cd Length: 254  Bit Score: 73.77  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  69 VLRQARALTDKIAVAAVKIGIPGSAANALAIARVIRALRERQPELPVVLDPVLASGHGDTLSRGDAVAALAPLL-PLVTV 147
Cdd:cd01173    60 LLEGLEALGLLLEYDAVLTGYLGSAEQVEAVAEIVKRLKEKNPNLLYVCDPVMGDNGKLYVVAEEIVPVYRDLLvPLADI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 148 LTPNGPEALALSAHTTPNAQ-----ARALRALGCRHVLITGGHGDGDEIVNrwfgpgaEAGAgsgrpPATQQWRWQR--- 219
Cdd:cd01173   140 ITPNQFELELLTGKKINDLEdakaaARALHAKGPKTVVVTSVELADDDRIE-------MLGS-----TATEAWLVQRpki 207

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2153801143 220 -LDGGFHGSGCTLASAIAGQLALGMPTGCALDQAQYYCNAALR 261
Cdd:cd01173   208 pFPAYFNGTGDLFAALLLARLLKGKSLAEALEKALNFVHEVLE 250
PdxK COG2240
Pyridoxal/pyridoxine/pyridoxamine kinase [Coenzyme transport and metabolism]; Pyridoxal ...
 91-271 4.02e-15

Pyridoxal/pyridoxine/pyridoxamine kinase [Coenzyme transport and metabolism]; Pyridoxal/pyridoxine/pyridoxamine kinase is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441841 [Multi-domain]  Cd Length: 272  Bit Score: 73.26  E-value: 4.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  91 GSAANALAIARVIRALRERQPELPVVLDPVLasGHGDTLSR---GDAVAALAPLLPLVTVLTPNGPEALALSAHTTPN-- 165
Cdd:COG2240    84 GSAEQGDIIADFVARVKAANPDALYLCDPVM--GDNGKGYYvfpGIAEFIMRRLVPLADIITPNLTELALLTGRPYETle 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 166 ---AQARALRALGCRHVLITGGHGDG---DEIVNRWFGPGaeagagsgrppatQQWRWQ--RLDGGFHGSGCTLASAIAG 237
Cdd:COG2240   162 ealAAARALLALGPKIVVVTSVPLDDtpaDKIGNLAVTAD-------------GAWLVEtpLLPFSPNGTGDLFAALLLA 228

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2153801143 238 QLALGMPTGCALDQAQYYCNAALRDAYgiAAGQR 271
Cdd:COG2240   229 HLLRGKSLEEALERAAAFVYEVLERTA--AAGSD 260
COG1992 COG1992
Predicted transcriptional regulator fused phosphomethylpyrimidine kinase (thiamin biosynthesis) ...
 22-244 1.30e-12

Predicted transcriptional regulator fused phosphomethylpyrimidine kinase (thiamin biosynthesis) [General function prediction only];


Pssm-ID: 441595 [Multi-domain]  Cd Length: 432  Bit Score: 67.09  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  22 DPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIpgsaaNALAIAR 101
Cdd:COG1992     1 GGGGGGGADAKTAAALGAGGGGTTTAVTVTATTTVTGVGSDPPPPVEVQQQAVAADDDVDDAKTGMLM-----TATIVEV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 102 VIRALRERQPELPVVLDPVLASGHGDTLsrGDAVAALA----PLLPLVTVLTPNGPEALALSAHTTPN---AQARALRAL 174
Cdd:COG1992    76 VAVVVKSRDKPLVVVVVPVAVAAAGLGL--LLAEAELAklllPLLATVTPNEPEVEELLLPTIRSLLAearAARLALQEE 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 175 GCRHVLITGGHGDGDEIVNRWFGPGAEAGAGSGRppatqqwrwqRLDGGFHGSGCTLASAIAGQLALGMP 244
Cdd:COG1992   154 GADALGVKGGHVSGDAVVDVLEDERDVETFRHPR----------LVTEATHGSGCTFSAAIAALLAKGLS 213
PTZ00493 PTZ00493
phosphomethylpyrimidine kinase; Provisional
 13-151 6.39e-12

phosphomethylpyrimidine kinase; Provisional


Pssm-ID: 240440  Cd Length: 321  Bit Score: 64.63  E-value: 6.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  13 PCVLVFAGMDPSGGAGIVADAQAVAGQGAHALCVVTALTVQDNDRAYEVQPVEPALVLRQARALTDKIAVAAVKIGIPGS 92
Cdd:PTZ00493    5 SNILSIAGSDSCGGAGMQADIKTAMGLGCHCCTALVVLTAQNTKEVKRIVEIEEKFIVEQLDSIFADVTIDVVKLGVLYS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2153801143  93 AAN-ALAIARVIRALRERQPELPVVLDPVLASGHGDTLSRG-DAVA-ALAPLLPLVTVLTPN 151
Cdd:PTZ00493   85 KKIiSLVHNYITNMNKKRGKKLLVVFDPVFVSSSGCLLVENlEYIKfALDLICPISCIITPN 146
RbsK COG0524
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ...
 98-192 8.95e-08

Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440290 [Multi-domain]  Cd Length: 301  Bit Score: 52.19  E-value: 8.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  98 AIARVIRALRERQpeLPVVLDPVLASGHGDtlsrgDAVAALAPLLPLVTVLTPNGPEALALSAHTTPNAQARALRALGCR 177
Cdd:COG0524   146 ALLAALEAARAAG--VPVSLDPNYRPALWE-----PARELLRELLALVDILFPNEEEAELLTGETDPEEAAAALLARGVK 218

                          90       100
                  ....*....|....*....|
gi 2153801143 178 HVLIT-GGHG----DGDEIV 192
Cdd:COG0524   219 LVVVTlGAEGallyTGGEVV 238
PRK05756 PRK05756
pyridoxal kinase PdxY;
82-182 1.24e-07

pyridoxal kinase PdxY;


Pssm-ID: 235592 [Multi-domain]  Cd Length: 286  Bit Score: 51.79  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  82 VAAVKIGIPGSAANALAIARVIRALRERQPELPVVLDPVLasGHGDtlsRGDAVAALAP------LLPLVTVLTPNGPEA 155
Cdd:PRK05756   75 CDAVLSGYLGSAEQGEAILDAVRRVKAANPQALYFCDPVM--GDPE---KGCIVAPGVAeflrdrALPAADIITPNLFEL 149

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2153801143 156 LALSAHTTPN-----AQARALRALGCRHVLIT 182
Cdd:PRK05756  150 EWLSGRPVETledavAAARALIARGPKIVLVT 181
pdxK PRK08176
pyridoxine/pyridoxal/pyridoxamine kinase;
69-182 7.63e-06

pyridoxine/pyridoxal/pyridoxamine kinase;


Pssm-ID: 181269 [Multi-domain]  Cd Length: 281  Bit Score: 46.19  E-value: 7.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  69 VLRQARALTdkiavaavkIGIPGSAANALAIARVIRALRERQPELPVVLDPVLAS-GHGDTLSRGDAVAALAPLLPLVTV 147
Cdd:PRK08176   85 ALRQLRAVT---------TGYMGSASQIKILAEWLTALRADHPDLLIMVDPVIGDiDSGIYVKPDLPEAYRQHLLPLAQG 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2153801143 148 LTPNGPEALALSAHTTPN-----AQARALRALGCRHVLIT 182
Cdd:PRK08176  156 LTPNIFELEILTGKPCRTldsaiAAAKSLLSDTLKWVVIT 195
PLN02978 PLN02978
pyridoxal kinase
 88-182 1.09e-05

pyridoxal kinase


Pssm-ID: 215529 [Multi-domain]  Cd Length: 308  Bit Score: 45.89  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  88 GIPGSAANALAIARVIRALRERQPELPVVLDPVLasghGDtlsRGD-AVAA-LAP-----LLPLVTVLTPNGPEALAL-- 158
Cdd:PLN02978   93 GYIGSVSFLRTVLRVVKKLRSVNPNLTYVCDPVL----GD---EGKlYVPPeLVPvyrekVVPLATMLTPNQFEAEQLtg 165

                          90       100
                  ....*....|....*....|....*..
gi 2153801143 159 -SAHTTPNAQA--RALRALGCRHVLIT 182
Cdd:PLN02978  166 iRIVTEEDAREacAILHAAGPSKVVIT 192
PRK07105 PRK07105
pyridoxamine kinase; Validated
 80-265 5.86e-04

pyridoxamine kinase; Validated


Pssm-ID: 180840 [Multi-domain]  Cd Length: 284  Bit Score: 40.67  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  80 IAVAAVKIGIPGSAANALAIARVIRALRerQPELPVVLDPVLasghGD------TLSRGdAVAALAPLLPLVTVLTPNGP 153
Cdd:PRK07105   74 LKFDAIYSGYLGSPRQIQIVSDFIKYFK--KKDLLVVVDPVM----GDngklyqGFDQE-MVEEMRKLIQKADVITPNLT 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 154 EA--LALSAHTTPNAQ-------ARALRALGCRHVLITGGHGDGDEI-----------VNRWFGPgaeagagsgRPPATq 213
Cdd:PRK07105  147 EAclLLDKPYLEKSYSeeeikqlLRKLADLGPKIVIITSVPFEDGKIgvayydratdrFWKVFCK---------YIPAH- 216

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2153801143 214 qwrwqrldggFHGSGCTLASAIAGQLALGMPTGCALDQAQYYCNAALRDAYG 265
Cdd:PRK07105  217 ----------YPGTGDIFTSVITGSLLQGDSLPIALDRAVQFIEKGIRATLG 258
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 48-184 3.01e-03

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 38.48  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  48 TALTVQDNDRAYEVQPVEPA-LVLRQARALTDKIAVAAVKI----GIPGSAANALAIARVIRALRERQPELPVVLDPvla 122
Cdd:pfam00294  90 TALIEVDGDGERTIVFNRGAaADLTPEELEENEDLLENADLlyisGSLPLGLPEATLEELIEAAKNGGTFDPNLLDP--- 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2153801143 123 sghgdtlsRGDAVAALAPLLPLVTVLTPNGPEALALS--AHTTPN---AQARALRALGCRHVLITGG 184
Cdd:pfam00294 167 --------LGAAREALLELLPLADLLKPNEEELEALTgaKLDDIEealAALHKLLAKGIKTVIVTLG 225
ribokinase_pfkB_like cd00287
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ...
 67-240 3.61e-03

ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).


Pssm-ID: 238177 [Multi-domain]  Cd Length: 196  Bit Score: 37.46  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143  67 ALVLRQARALTDKIAVAAVK-IGIPGSAANALAIARVIRALRERQpeLPVVLDPVLASGHGDTlsrgdavAALAPLLPLV 145
Cdd:cd00287    40 ANVAVALARLGVSVTLVGADaVVISGLSPAPEAVLDALEEARRRG--VPVVLDPGPRAVRLDG-------EELEKLLPGV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2153801143 146 TVLTPNGPEALAL-----SAHTTPNAQARALRALGCRHVLITGGHGDGdeivnRWFGPGAEAGAGSGRPPATqqwrwqrl 220
Cdd:cd00287   111 DILTPNEEEAEALtgrrdLEVKEAAEAAALLLSKGPKVVIVTLGEKGA-----IVATRGGTEVHVPAFPVKV-------- 177

                         170       180
                  ....*....|....*....|
gi 2153801143 221 dGGFHGSGCTLASAIAGQLA 240
Cdd:cd00287   178 -VDTTGAGDAFLAALAAGLA 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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