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Conserved domains on  [gi|2152256882|ref|WP_229108416|]
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MULTISPECIES: site-specific DNA-methyltransferase [Alistipes]

Protein Classification

DNA-methyltransferase( domain architecture ID 10002921)

DNA methyltransferase catalyzes specific methylation on cytosine or adenine on both strands and protects the DNA from cleavage by endonuclease; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
6-332 1.49e-68

DNA modification methylase [Replication, recombination and repair];


:

Pssm-ID: 440623  Cd Length: 236  Bit Score: 214.40  E-value: 1.49e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882   6 IFNTDALSALRGLDDDCVDCIVTSPPYWQLRDYGLapilfggngtcrhefdgfgvcrlcggWLGQLGQEPSRELFIEHLV 85
Cdd:COG0863     2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGL--------------------------GRREIGNELSFEEYLEFLR 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  86 SIFDECRRVLKKSGTLWVNLGDSYSKLnkynrpndypgrknayclkelrvdlsahrvphkslcnipglFAETMILRGWIL 165
Cdd:COG0863    56 EWLAECYRVLKPGGSLYVNIGDRYISR-----------------------------------------LIAALRDAGFKL 94

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 166 RNEIIWYKPSVVPTPVKDRFTVDFEKVFFFTKAPKYdfrqqfepyaestcgryerGFDVERAKGKgyreygcpagvkein 245
Cdd:COG0863    95 RNEIIWRKPNGVPGPSKRRFRNSHEYILWFTKGKKY-------------------TFNVDAVKSI--------------- 140

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 246 PKGRNKRTVWRITSENNHE--MHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIA 323
Cdd:COG0863   141 EDGRNPSDVWDIPGVTPKErkGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVA 220


                  ....*....
gi 2152256882 324 RVRLERESG 332
Cdd:COG0863   221 RRRLEEATG 229
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
6-332 1.49e-68

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 214.40  E-value: 1.49e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882   6 IFNTDALSALRGLDDDCVDCIVTSPPYWQLRDYGLapilfggngtcrhefdgfgvcrlcggWLGQLGQEPSRELFIEHLV 85
Cdd:COG0863     2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGL--------------------------GRREIGNELSFEEYLEFLR 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  86 SIFDECRRVLKKSGTLWVNLGDSYSKLnkynrpndypgrknayclkelrvdlsahrvphkslcnipglFAETMILRGWIL 165
Cdd:COG0863    56 EWLAECYRVLKPGGSLYVNIGDRYISR-----------------------------------------LIAALRDAGFKL 94

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 166 RNEIIWYKPSVVPTPVKDRFTVDFEKVFFFTKAPKYdfrqqfepyaestcgryerGFDVERAKGKgyreygcpagvkein 245
Cdd:COG0863    95 RNEIIWRKPNGVPGPSKRRFRNSHEYILWFTKGKKY-------------------TFNVDAVKSI--------------- 140

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 246 PKGRNKRTVWRITSENNHE--MHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIA 323
Cdd:COG0863   141 EDGRNPSDVWDIPGVTPKErkGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVA 220


                  ....*....
gi 2152256882 324 RVRLERESG 332
Cdd:COG0863   221 RRRLEEATG 229
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 23-323 1.57e-45

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 154.48  E-value: 1.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  23 VDCIVTSPPYWQLRDYGlapilfggngtcrhefdgfgvcrlcggwlgQLGQEPSRELFIEHLVSIFDECRRVLKKSGTLW 102
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYG------------------------------QWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIF 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 103 VNLGDSYSKlnkynrpndypgrknayclkelrvdlsahrvPHKSLCNipglfaetMILRGWILRNEIIWYKPSVVPTPVK 182
Cdd:pfam01555  51 INIGDSNIK-------------------------------SLKALAL--------EILGIFKLLNDIIWRKPNGMPNSNG 91

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 183 DRFTVDFEKVFFFTKAPKYdfrqqfepyaestcgrYERGFDVERAKGKGYREygcpAGVKEINPKGRNKRTVWRITSENN 262
Cdd:pfam01555  92 ERFTPAHEYILWFSKTKKY----------------KTFNYDAIKVPYDEKDK----LKKRGSEPNGKPIGDVWDFSRVQP 151

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2152256882 263 HE-------MHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIA 323
Cdd:pfam01555 152 SEkesggngKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEIA 219
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
5-328 7.13e-18

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 82.46  E-value: 7.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882   5 VIFNTDALSALRGLDDDCVDCIVTSPPYwqlrdyglapiLFGGNgtcrheFDGFgvcrlCGGWLgqlgqepsRELFIEHL 84
Cdd:PRK11524   10 TIIHGDALTELKKIPSESVDLIFADPPY-----------NIGKN------FDGL-----IEAWK--------EDLFIDWL 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  85 VSIFDECRRVLKKSGTLWVnlgdsysklnkynrpndypgrknayclkelrvdlsahrvpHKSLCNIPGLfaeTMILRGWI 164
Cdd:PRK11524   60 YEWIDECHRVLKKQGTMYI----------------------------------------MNSTENMPFI---DLYCRKLF 96

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 165 -LRNEIIW-YKPSVVPTpvKDRFTVDFEKVFFFTKAPK-YDFRQQfEPYAESTCGRYERGFDVERAKGKGYREYGCPAGV 241
Cdd:PRK11524   97 tIKSRIVWsYDSSGVQA--KKYFGSMYEPILMMVKDAKnYTFNGD-AILVEAKTGAKRALIDYRKNPPQPYNTQKVPGNV 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 242 KEInpkgrnKRTVWRItseNNHEMHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAA 321
Cdd:PRK11524  174 WDF------PRVRYLM---DEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINSEYIK 244


                  ....*..
gi 2152256882 322 IARVRLE 328
Cdd:PRK11524  245 MGLRRLD 251
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
6-332 1.49e-68

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 214.40  E-value: 1.49e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882   6 IFNTDALSALRGLDDDCVDCIVTSPPYWQLRDYGLapilfggngtcrhefdgfgvcrlcggWLGQLGQEPSRELFIEHLV 85
Cdd:COG0863     2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGL--------------------------GRREIGNELSFEEYLEFLR 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  86 SIFDECRRVLKKSGTLWVNLGDSYSKLnkynrpndypgrknayclkelrvdlsahrvphkslcnipglFAETMILRGWIL 165
Cdd:COG0863    56 EWLAECYRVLKPGGSLYVNIGDRYISR-----------------------------------------LIAALRDAGFKL 94

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 166 RNEIIWYKPSVVPTPVKDRFTVDFEKVFFFTKAPKYdfrqqfepyaestcgryerGFDVERAKGKgyreygcpagvkein 245
Cdd:COG0863    95 RNEIIWRKPNGVPGPSKRRFRNSHEYILWFTKGKKY-------------------TFNVDAVKSI--------------- 140

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 246 PKGRNKRTVWRITSENNHE--MHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIA 323
Cdd:COG0863   141 EDGRNPSDVWDIPGVTPKErkGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVA 220


                  ....*....
gi 2152256882 324 RVRLERESG 332
Cdd:COG0863   221 RRRLEEATG 229
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 23-323 1.57e-45

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 154.48  E-value: 1.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  23 VDCIVTSPPYWQLRDYGlapilfggngtcrhefdgfgvcrlcggwlgQLGQEPSRELFIEHLVSIFDECRRVLKKSGTLW 102
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYG------------------------------QWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIF 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 103 VNLGDSYSKlnkynrpndypgrknayclkelrvdlsahrvPHKSLCNipglfaetMILRGWILRNEIIWYKPSVVPTPVK 182
Cdd:pfam01555  51 INIGDSNIK-------------------------------SLKALAL--------EILGIFKLLNDIIWRKPNGMPNSNG 91

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 183 DRFTVDFEKVFFFTKAPKYdfrqqfepyaestcgrYERGFDVERAKGKGYREygcpAGVKEINPKGRNKRTVWRITSENN 262
Cdd:pfam01555  92 ERFTPAHEYILWFSKTKKY----------------KTFNYDAIKVPYDEKDK----LKKRGSEPNGKPIGDVWDFSRVQP 151

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2152256882 263 HE-------MHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIA 323
Cdd:pfam01555 152 SEkesggngKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEIA 219
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
5-328 7.13e-18

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 82.46  E-value: 7.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882   5 VIFNTDALSALRGLDDDCVDCIVTSPPYwqlrdyglapiLFGGNgtcrheFDGFgvcrlCGGWLgqlgqepsRELFIEHL 84
Cdd:PRK11524   10 TIIHGDALTELKKIPSESVDLIFADPPY-----------NIGKN------FDGL-----IEAWK--------EDLFIDWL 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882  85 VSIFDECRRVLKKSGTLWVnlgdsysklnkynrpndypgrknayclkelrvdlsahrvpHKSLCNIPGLfaeTMILRGWI 164
Cdd:PRK11524   60 YEWIDECHRVLKKQGTMYI----------------------------------------MNSTENMPFI---DLYCRKLF 96

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 165 -LRNEIIW-YKPSVVPTpvKDRFTVDFEKVFFFTKAPK-YDFRQQfEPYAESTCGRYERGFDVERAKGKGYREYGCPAGV 241
Cdd:PRK11524   97 tIKSRIVWsYDSSGVQA--KKYFGSMYEPILMMVKDAKnYTFNGD-AILVEAKTGAKRALIDYRKNPPQPYNTQKVPGNV 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 242 KEInpkgrnKRTVWRItseNNHEMHYATYPTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAA 321
Cdd:PRK11524  174 WDF------PRVRYLM---DEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINSEYIK 244


                  ....*..
gi 2152256882 322 IARVRLE 328
Cdd:PRK11524  245 MGLRRLD 251
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
271-335 1.06e-11

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 65.57  E-value: 1.06e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2152256882 271 PTKLVETPVEAGCPPGGVVLDPFLGSGTTAVVARRLG------RHYIGIEpNPEYA-AIARVRLERESGSIK 335
Cdd:COG2189   306 PEKLLKRIIEIATNPGDLVLDFFAGSGTTAHAVMKLNaedggnRRFILVQ-LGEYAdTVTKERLRRVIDGIS 376
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 265-328 9.54e-10

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 56.88  E-value: 9.54e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2152256882 265 MHYATYPT----KLVETPVE-AGCPPGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIARVRLE 328
Cdd:COG1041     1 MKYFFYPGsldpRLARALVNlAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLE 69
PRK13699 PRK13699
putative methylase; Provisional
 255-327 1.75e-09

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 57.15  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2152256882 255 WRITSENNHemhyatyPTklvETPVEAGCP-------PGGVVLDPFLGSGTTAVVARRLGRHYIGIEPNPEYAAIARVRL 327
Cdd:PRK13699  136 WKYSGNRHH-------PT---EKPVTSLQPliesfthPNAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRL 205
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 279-329 1.56e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.77  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2152256882 279 VEAGCPPGGVVLDpfLGSGT--TAVVARRLGRHYIGIEPNPEYAAIARVRLER 329
Cdd:COG2227    18 LARLLPAGGRVLD--VGCGTgrLALALARRGADVTGVDISPEALEIARERAAE 68
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 280-335 1.94e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.13  E-value: 1.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2152256882 280 EAGCPPGGVVLDpfLGSGT--TAVVARRLGRHYIGIEPNPEYAAIARVRLERESGSIK 335
Cdd:COG2226    17 ALGLRPGARVLD--LGCGTgrLALALAERGARVTGVDISPEMLELARERAAEAGLNVE 72
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 289-335 2.09e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 39.85  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2152256882 289 VLDpfLGSGT---TAVVARRLGRHYIGIEPNPEYAAIARVRLERESGSIK 335
Cdd:pfam13649   1 VLD--LGCGTgrlTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVE 48
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 266-330 1.64e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 39.13  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2152256882 266 HYATYPTKLVETPVEAGCPPGGVVLDpfLGSGT---TAVVARRLGRHYIGIEPNPEYAAIARVRLERE 330
Cdd:COG0500     7 SDELLPGLAALLALLERLPKGGRVLD--LGCGTgrnLLALAARFGGRVIGIDLSPEAIALARARAAKA 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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