NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2131121223|ref|WP_228371078|]
View 

lipopolysaccharide assembly protein LapB [Shewanella piezotolerans]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 215-367 1.18e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.31  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 215 KGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADVHK 294
Cdd:COG2956    55 RGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLE 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2131121223 295 VMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG2956   135 RLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 215-367 1.18e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.31  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 215 KGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADVHK 294
Cdd:COG2956    55 RGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLE 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2131121223 295 VMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG2956   135 RLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 212-334 1.05e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.93  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 212 ALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEwAD 291
Cdd:TIGR02917 169 ALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEE-AE 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2131121223 292 VHKVMELARIRN-PYYYYSMAQQAYFDKEYKLALNWYKKAIDKA 334
Cdd:TIGR02917 248 KHADALLKKAPNsPLAHYLKALVDFQKKNYEDARETLQDALKSA 291
TPR_19 pfam14559
Tetratricopeptide repeat;
216-269 3.30e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 3.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 216 GQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDD 269
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDD 55
PRK15331 PRK15331
type III secretion system translocator chaperone SicA;
265-343 9.16e-03

type III secretion system translocator chaperone SicA;


Pssm-ID: 185231  Cd Length: 165  Bit Score: 36.58  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 265 IDPDDMNALYNYAIILGEQNRLDEWADVHKVMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKA--IDKADYRHEFYF 342
Cdd:PRK15331   32 IPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAVCQLKKQFQKACDLYAVAftLLKNDYRPVFFT 111


                  .
gi 2131121223 343 G 343
Cdd:PRK15331  112 G 112
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 215-367 1.18e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.31  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 215 KGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADVHK 294
Cdd:COG2956    55 RGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLE 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2131121223 295 VMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG2956   135 RLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
205-385 5.27e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.89  E-value: 5.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 205 YNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQN 284
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 285 RLDE-WADVHKVMELaRIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEK 363
Cdd:COG0457    91 RYEEaLEDYDKALEL-DPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEK 169

                         170       180
                  ....*....|....*....|..
gi 2131121223 364 ALSLTNDLNNKHRYQSKLHAMR 385
Cdd:COG0457   170 LEAAALAALLAAALGEAALALA 191
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 212-367 1.00e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 73.61  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 212 ALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWAD 291
Cdd:COG2956    18 YLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEE 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2131121223 292 VHKVMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG2956    98 LLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL 173
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 209-359 2.20e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 71.56  E-value: 2.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 209 AAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE 288
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131121223 289 WADVHKvmELARIR--NPYYYYSMAqQAYFD-KEYKLALNWYKKAI----DKADYRHEFYFGLSRTYWATGDERRAQV 359
Cdd:COG3914   165 AIAALR--RALELDpdNAEALNNLG-NALQDlGRLEEAIAAYRRALeldpDNADAHSNLLFALRQACDWEVYDRFEEL 239
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
229-367 7.40e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 7.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 229 LQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE-WADVHKVMELArIRNPYYY 307
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEaLADYEQALELD-PDDAEAL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 308 YSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG0457    80 NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 236-370 2.52e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.98  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 236 LPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE-WADVHKVMELARiRNPYYYYSMAQQA 314
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEaIVLLHEALELDP-DEPEARLNLGLAL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131121223 315 YFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSLTND 370
Cdd:COG4783    83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 209-334 3.05e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.59  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 209 AAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE 288
Cdd:COG4783    11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2131121223 289 WADVHKVMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKA 334
Cdd:COG4783    91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 205-288 4.95e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.24  E-value: 4.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 205 YNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQN 284
Cdd:COG3914   115 LFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLG 194


                  ....
gi 2131121223 285 RLDE 288
Cdd:COG3914   195 RLEE 198
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
245-334 2.59e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 56.72  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 245 LYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADVHKVMELARiRNPYYYYSMAQQAYFDKEYKLAL 324
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDP-NNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|
gi 2131121223 325 NWYKKAIDKA 334
Cdd:COG3063    80 AYLERALELD 89
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 204-371 3.41e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 3.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 204 YYNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQ 283
Cdd:COG2956    78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 284 NRLDEwadVHKVMELARIRNPYY---YYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVN 360
Cdd:COG2956   158 GDYDE---AIEALEKALKLDPDCaraLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALEL 234

                         170
                  ....*....|.
gi 2131121223 361 MEKALSLTNDL 371
Cdd:COG2956   235 LRKALELDPSD 245
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 213-288 1.60e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.70  E-value: 1.60e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2131121223 213 LVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE 288
Cdd:COG4235    28 LRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
205-358 1.90e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 1.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 205 YNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQN 284
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 285 RLDEWADVHKVMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQ 358
Cdd:COG0457   159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 220-335 1.98e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 220 KAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE-WADVHKVMEL 298
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEaEELLERALAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2131121223 299 ARiRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKAD 335
Cdd:COG4235    81 DP-DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 204-333 3.77e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 3.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 204 YYNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQ 283
Cdd:COG2956   146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKL 225

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2131121223 284 NRLDEWADV-HKVMELARIRNPYYYYSMAQQAYfdKEYKLALNWYKKAIDK 333
Cdd:COG2956   226 GDPEEALELlRKALELDPSDDLLLALADLLERK--EGLEAALALLERQLRR 274
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 209-385 4.84e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.00  E-value: 4.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 209 AAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE 288
Cdd:COG3914    51 LAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 289 WADV-HKVMELARiRNPYYYYSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG3914   131 ALAAlRRALALNP-DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209

                         170
                  ....*....|....*...
gi 2131121223 368 tnDLNNKHRYQSKLHAMR 385
Cdd:COG3914   210 --DPDNADAHSNLLFALR 225
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 212-334 1.05e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.93  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 212 ALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEwAD 291
Cdd:TIGR02917 169 ALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEE-AE 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2131121223 292 VHKVMELARIRN-PYYYYSMAQQAYFDKEYKLALNWYKKAIDKA 334
Cdd:TIGR02917 248 KHADALLKKAPNsPLAHYLKALVDFQKKNYEDARETLQDALKSA 291
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 204-294 3.52e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 204 YYNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQ 283
Cdd:COG4783    40 AFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRAL 119

                          90
                  ....*....|.
gi 2131121223 284 NRLDEWADVHK 294
Cdd:COG4783   120 GRPDEAIAALE 130
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 215-288 3.80e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 3.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 215 KGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDE 288
Cdd:COG5010    67 LGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
215-288 4.76e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.47  E-value: 4.76e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 215 KGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEAlYKLALTIDPDDMNALYNYAIILGEQNRLDE 288
Cdd:COG3063     5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDE 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 201-298 6.39e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 6.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 201 ASMYYNnvAAEALVK-GQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAII 279
Cdd:COG3914   146 AEAYLN--LGEALRRlGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFA 223

                          90
                  ....*....|....*....
gi 2131121223 280 LGEQNRLDEWADVHKVMEL 298
Cdd:COG3914   224 LRQACDWEVYDRFEELLAA 242
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 205-367 7.23e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 7.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 205 YNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQN 284
Cdd:TIGR02917 468 HNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 285 RLDEwadVHKVMELARIRNPYYY---YSMAQQAYFDKEYKLALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNM 361
Cdd:TIGR02917 548 NEEE---AVAWLEKAAELNPQEIepaLALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624


                  ....*.
gi 2131121223 362 EKALSL 367
Cdd:TIGR02917 625 KKLLAL 630
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 201-367 9.22e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 9.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 201 ASMYYNNVAAEALVKGQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIIL 280
Cdd:COG5010    19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 281 GEQNRLDEwadvhkvmelarirnpyyyysmaqqayfdkeyklALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVN 360
Cdd:COG5010    99 SRSGDKDE----------------------------------AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                  ....*..
gi 2131121223 361 MEKALSL 367
Cdd:COG5010   145 LQRALGT 151
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
185-335 1.19e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.06  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 185 RAMQGYDKRRVSQSMVASMYYNNVAAEALVKGQYDKAYGLLKLSLQQDNQfLPAINTLAVLYRYKGLIEEAEALYKLALT 264
Cdd:COG4785    23 AILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDL-AQLYYERGVAYDSLGDYDLAIADFDQALE 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2131121223 265 IDPDDMNALYNYAIILGEQNRLDE-WADVHKVMELarirNPYYYYSMAQQA---YFDKEYKLALNWYKKAIDKAD 335
Cdd:COG4785   102 LDPDLAEAYNNRGLAYLLLGDYDAaLEDFDRALEL----DPDYAYAYLNRGialYYLGRYELAIADLEKALELDP 172
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 242-370 3.47e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 242 LAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADVHKVMELARIRNPYYYYSMAQQAYFDKEYK 321
Cdd:COG2956    14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2131121223 322 LALNWYKKAIDKADYRHEFYFGLSRTYWATGDERRAQVNMEKALSLTND 370
Cdd:COG2956    94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 254-367 1.58e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 254 EAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADV-HKVMELARiRNPYYYYSMAQQAYFDKEYKLALNWYKKAID 332
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAyEKALRLDP-DNADALLDLAEALLAAGDTEEAEELLERALA 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2131121223 333 KADYRHEFYFGLSRTYWATGDERRAQVNMEKALSL 367
Cdd:COG4235    80 LDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 210-382 3.58e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 210 AEALVK-GQYDKAYGLL-KLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLD 287
Cdd:TIGR02917  97 ARAYLLqGKFQQVLDELpGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFD 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 288 E-WADVHKVMElARIRNPYYYYSMAQQAYFDKEYKLALNWYKKAIdKADYRHE-FYFGLSRTYWATGDERRAQVNMEKAL 365
Cdd:TIGR02917 177 EaRALIDEVLT-ADPGNVDALLLKGDLLLSLGNIELALAAYRKAI-ALRPNNIaVLLALATILIEAGEFEEAEKHADALL 254

                         170
                  ....*....|....*..
gi 2131121223 366 SLTNDLNNKHRYQSKLH 382
Cdd:TIGR02917 255 KKAPNSPLAHYLKALVD 271
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
205-268 1.44e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 205 YNNVAAEALVKGQYDKAYGLLKlSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPD 268
Cdd:COG3063    29 LNNLGLLLLEQGRYDEAIALEK-ALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 226-334 2.61e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 226 KLSLQQDNQFlPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNALYNYAIILGEQNRLDEWADVHKVMELARIRNPY 305
Cdd:TIGR02917 626 KLLALQPDSA-LALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAAL 704

                          90       100
                  ....*....|....*....|....*....
gi 2131121223 306 YYYSMAQQAYFDKEYKLALNWYKKAIDKA 334
Cdd:TIGR02917 705 GFELEGDLYLRQKDYPAAIQAYRKALKRA 733
TPR_19 pfam14559
Tetratricopeptide repeat;
216-269 3.30e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 3.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 216 GQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDD 269
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDD 55
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 210-272 4.78e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 4.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2131121223 210 AEALVK-GQYDKAYGLLKLSLQQDNQFLPAINTLAVLYRYKGLIEEAEALYKLALTIDPDDMNA 272
Cdd:COG4235    58 AEALLAaGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
PRK15331 PRK15331
type III secretion system translocator chaperone SicA;
265-343 9.16e-03

type III secretion system translocator chaperone SicA;


Pssm-ID: 185231  Cd Length: 165  Bit Score: 36.58  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131121223 265 IDPDDMNALYNYAIILGEQNRLDEWADVHKVMELARIRNPYYYYSMAQQAYFDKEYKLALNWYKKA--IDKADYRHEFYF 342
Cdd:PRK15331   32 IPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAVCQLKKQFQKACDLYAVAftLLKNDYRPVFFT 111


                  .
gi 2131121223 343 G 343
Cdd:PRK15331  112 G 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH