|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
375-609 |
4.75e-60 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 200.13 E-value: 4.75e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 375 LREKIEALQAERALREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLD-QRRDLALRIDRNIERTDQMVRDLLDANRIQG 453
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 454 GqRLPLRLDMCDLGGVAQEVVEELIALHGDR---FVLH-AEERVRGIWSAEELRRALWNLGSNAIKYGAATEPITFTVTR 529
Cdd:COG2205 82 G-KLSLELEPVDLAELLEEAVEELRPLAEEKgirLELDlPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 530 AGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKgtSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLDA 609
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
319-607 |
5.17e-54 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 187.04 E-value: 5.17e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 319 LRSLLGVRLPPHRALVGIMYVGLAEVREFTAREKARLLSLGQQLSVHLDNAKLYANLREKIEALQAERALREqFVSVLAH 398
Cdd:COG0642 41 LLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSR-FLANVSH 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 399 DLRGPLSAAKSGAQLLMRHPErlDQRRDLALRIDRNIERTDQMVRDLLDANRIQGGqRLPLRLDMCDLGGVAQEVVEELI 478
Cdd:COG0642 120 ELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAG-KLELEPEPVDLAELLEEVVELFR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 479 ALHGDR---FVLHAEERVRGIWS-AEELRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIF 554
Cdd:COG0642 197 PLAEEKgieLELDLPDDLPTVRGdPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIF 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2111051364 555 KPFTRTHSAQKGtsKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:COG0642 277 EPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
236-607 |
4.93e-51 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 180.90 E-value: 4.93e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 236 VLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASMNPASFPGRVAAGGEETSTVLDAETTPLEVSQTLR 315
Cdd:COG5002 14 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 316 QNGLRSLLGVRLPPHRALVGIMYVGLAEVREFTAREKARLLSLGQqlSVHLDNAKLYANLREKIEALQAERALREQFVSV 395
Cdd:COG5002 94 LLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRL--SALLLGLLLLAAVERDITELERLEQMRREFVAN 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 396 LAHDLRGPLSAAKSGAQLLMRHPERL-DQRRDLALRIDRNIERTDQMVRDLLDANRIQGGqRLPLRLDMCDLGGVAQEVV 474
Cdd:COG5002 172 VSHELRTPLTSIRGYLELLLDGAADDpEERREYLEIILEEAERLSRLVNDLLDLSRLESG-ELKLEKEPVDLAELLEEVV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 475 EELIAL---HGDRFVLHAEE---RVRGiwSAEELRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPA 548
Cdd:COG5002 251 EELRPLaeeKGIELELDLPEdplLVLG--DPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEE 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2111051364 549 DLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:COG5002 329 DLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
110-610 |
1.05e-39 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 152.25 E-value: 1.05e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 110 LASLADEEGVPGALVHARPTHVETHVAARLRQGFNVAEVIEEFAILGRCIASMWANASPEARPSALDVERLFTKLHAAST 189
Cdd:COG4251 4 LALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 190 AVSERFSRHLLEDEQTEKRYLRLLQKVANEALVDEDEASLRDHLKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGL 269
Cdd:COG4251 84 LLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 270 ASEQLEHYVASMNPASFPGRVAAGGEETSTVLDAETTPLEVSQTLRQNGLRSLLGVRLPPHRALVGIMYVGLAEVREFTA 349
Cdd:COG4251 164 LALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLIL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 350 REkARLLSLGQQLSVHLDNAKLYANLREKIEALQAERALREQFVSVLAHDLRGPLSAAKSGAQLL-MRHPERLDQR-RDL 427
Cdd:COG4251 244 LL-LLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLeEDYGDKLDEEgREY 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 428 ALRIDRNIERTDQMVRDLLDANRIqggQRLPLRLDMCDLGGVAQEVVEELIALHGDR-FVLHAEE--RVRGIwsAEELRR 504
Cdd:COG4251 323 LERIRDAAERMQALIDDLLAYSRV---GRQELEFEPVDLNELLEEVLEDLEPRIEERgAEIEVGPlpTVRGD--PTLLRQ 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 505 ALWNLGSNAIKYGAATEP--ITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQK--GTskgwGLGLTLVWG 580
Cdd:COG4251 398 VFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEyeGT----GIGLAIVKK 473
|
490 500 510
....*....|....*....|....*....|
gi 2111051364 581 CAQAHGGTVTVQSDAATGTTFTLKLPLDAR 610
Cdd:COG4251 474 IVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
380-611 |
1.40e-29 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 121.61 E-value: 1.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 380 EALQAER--ALREqFVSVLAHDLRGPLSAAKSGAQLLMRH-PERLDQRRDLALR----IDRNIERTDQMVRDLLDANRIQ 452
Cdd:COG5000 191 ELLRAERlaAWGE-LARRIAHEIKNPLTPIQLSAERLRRKlADKLEEDREDLERaldtIIRQVDRLKRIVDEFLDFARLP 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 453 ggqrlPLRLDMCDLGGVAQEVV---EELIALHGDRFVLHAEERVRGIWS-AEELRRALWNLGSNAIKYGAATEPITFTVT 528
Cdd:COG5000 270 -----EPQLEPVDLNELLREVLalyEPALKEKDIRLELDLDPDLPEVLAdRDQLEQVLINLLKNAIEAIEEGGEIEVSTR 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 529 RAGDRARASVHNRGPVIAPADLEHIFKPF--TRthsaqkgtSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:COG5000 345 REDGRVRIEVSDNGPGIPEEVLERIFEPFftTK--------PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
....*
gi 2111051364 607 LDARP 611
Cdd:COG5000 417 LAEEA 421
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
211-606 |
3.09e-28 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 118.26 E-value: 3.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 211 RLLQKVANEALVDEDEASLRDHLKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASMNPASFPGRV 290
Cdd:TIGR01386 52 RFLRDPADLDEDIKRLQEKIDDLLVGHSDLALSILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILRS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 291 AA---GGEETSTVLDAETTPLEVSQTLRQNGLRSLLG--VRLPPHRALVG--IMYVGLAEVREFtaREKARLLSLgQQLS 363
Cdd:TIGR01386 132 VAalpGGKGRKPVQITVALDINAHTHLLDALRKWLILiaVLLVLLTALLGwwITRLGLEPLRRL--SAVAARISP-ESLD 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 364 VHLDNAKLYANLREKIEALQA-----ERALR--EQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRIDRNIE 436
Cdd:TIGR01386 209 QRLDPSRAPAELRELAQSFNAmlgrlEDAFQrlSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELE 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 437 RTDQMVRDLLDANRIQGGQRLPLRLDMcDLGGVAQEVVEELIALHGDRFV---LHAEERVRGiwSAEELRRALWNLGSNA 513
Cdd:TIGR01386 289 RLSRMVSDMLFLARADNGQLALERVRL-DLAAELAKVAEYFEPLAEERGVrirVEGEGLVRG--DPQMFRRAISNLLSNA 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 514 IKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGGTVTVQS 593
Cdd:TIGR01386 366 LRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAES 445
|
410
....*....|...
gi 2111051364 594 DAATgTTFTLKLP 606
Cdd:TIGR01386 446 PDGK-TRFILRFP 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
260-607 |
3.18e-28 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 116.44 E-value: 3.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 260 QLVTAAAAGLASEQLEHYVASMNPASFPGRVAAGGEETSTVLDAETTPLEVSQTLRQNGLRSLLGVRLPPHRALVGIMYV 339
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 340 GLAEVREFTAREKARLLSLGQQLSVHLDNAKLYANLREKIEALQAERALREQFV------------SVLAHDLRGPLSAA 407
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVqseklaalgelaAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 408 KSGAQLLMRHPER---LDQRRDLALRIDRNIERTDQMVRDLLDANRIQGGQRLPLRLDmcdlggvaqEVVEELIAL---- 480
Cdd:COG4191 161 LGNAELLRRRLEDepdPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLN---------ELIDEALELlrpr 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 481 ---HGDRFVLHAEERVRGIW-SAEELRRALWNLGSNAIKygaATEP-----ITFTVTRAGDRARASVHNRGPVIAPADLE 551
Cdd:COG4191 232 lkaRGIEVELDLPPDLPPVLgDPGQLEQVLLNLLINAID---AMEEgeggrITISTRREGDYVVISVRDNGPGIPPEVLE 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2111051364 552 HIFKPFTRTHSAQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:COG4191 309 RIFEPFFTTKPVGKGT----GLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
320-607 |
1.85e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 111.09 E-value: 1.85e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 320 RSLLGVRL----PPHRALVGIMYVGLAEVREFTAREKARLLSLGQQLSVHLDNAKLYAN---------LREKIEALQAER 386
Cdd:COG3852 45 EELLGRPLaelfPEDSPLRELLERALAEGQPVTEREVTLRRKDGEERPVDVSVSPLRDAegeggvllvLRDITERKRLER 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 387 ALR--EQFVSV------LAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALrIDRNIERTDQMVRDLLDANRIQGGQRLP 458
Cdd:COG3852 125 ELRraEKLAAVgelaagLAHEIRNPLTGIRGAAQLLERELPDDELREYTQL-IIEEADRLNNLVDRLLSFSRPRPPEREP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 459 LRLDmcdlggvaqEVVEELIAL------HGDRFVLHAEERVRGIW-SAEELRRALWNLGSNAIKygAATEP--ITFTV-- 527
Cdd:COG3852 204 VNLH---------EVLERVLELlraeapKNIRIVRDYDPSLPEVLgDPDQLIQVLLNLVRNAAE--AMPEGgtITIRTrv 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 528 --------TRAGDRARASVHNRGPVIAPADLEHIFKPF--TRthsaQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAAT 597
Cdd:COG3852 273 erqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFftTK----EKGT----GLGLAIVQKIVEQHGGTIEVESEPGK 344
|
330
....*....|
gi 2111051364 598 GTTFTLKLPL 607
Cdd:COG3852 345 GTTFRIYLPL 354
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
502-605 |
7.09e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 101.91 E-value: 7.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGtsKGWGLGLTLVWGC 581
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKL 605
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
502-607 |
1.33e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 101.57 E-value: 1.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSkGWGLGLTLVWGC 581
Cdd:smart00387 6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIG-GTGLGLSIVKKL 84
|
90 100
....*....|....*....|....*.
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:smart00387 85 VELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
369-609 |
8.80e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 101.84 E-value: 8.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 369 AKLYANLREKIEAlqaeRALREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERlDQRRDLALRIDRNIERTDQMVRDLLDA 448
Cdd:PRK11100 240 AQALESMRVKLEG----KAYVEQYVQTLTHELKSPLAAIRGAAELLQEDPPP-EDRARFTGNILTQSARLQQLIDRLLEL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 449 NRIQGGQRLpLRLDMCDLGGVAQEVVEEL---IALHGDRFVLHAEErVRGIWSAEELRRALWNLGSNAIKYGAATEPITF 525
Cdd:PRK11100 315 ARLEQRQEL-EVLEPVALAALLEELVEAReaqAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 526 TVTRAGDRARASVHNRGPVIAPADLEHIFKPF---TRTHSAQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAATGTTFT 602
Cdd:PRK11100 393 SAEVDGEQVALSVEDQGPGIPDYALPRIFERFyslPRPANGRKST----GLGLAFVREVARLHGGEVTLRNRPEGGVLAT 468
|
....*..
gi 2111051364 603 LKLPLDA 609
Cdd:PRK11100 469 LTLPRHF 475
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
502-608 |
4.19e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 91.66 E-value: 4.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRaGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGtskGWGLGLTLVWGC 581
Cdd:pfam02518 6 LRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG---GTGLGLSIVRKL 81
|
90 100
....*....|....*....|....*..
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLPLD 608
Cdd:pfam02518 82 VELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
364-615 |
6.32e-22 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 98.91 E-value: 6.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 364 VHLDNAKLYANL-------REKIEALQAERalrEQFVSVLAHDLRGPLsaaksgaqllMRHPERLDQRRDL----ALRID 432
Cdd:PRK10604 183 IHFDEGSSLERLgvafnqmADNINALIASK---KQLIDGIAHELRTPL----------VRLRYRLEMSDNLsaaeSQALN 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 433 RNIERTDQMVRDLLDANRIQGgQRLPLRLDMCDLGGVAQEVVEELIALHGDRfVLHAEERVRGIWSAEELR---RALWNL 509
Cdd:PRK10604 250 RDIGQLEALIEELLTYARLDR-PQNELHLSEPDLPAWLSTHLADIQAVTPEK-TVRLDTPHQGDYGALDMRlmeRVLDNL 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 510 GSNAIKYgaATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGGTV 589
Cdd:PRK10604 328 LNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSV 405
|
250 260
....*....|....*....|....*...
gi 2111051364 590 TVQSDAATGTTFTLKLP--LDARPYQPR 615
Cdd:PRK10604 406 NCDESELGGARFSFSWPvwHNLPQFTSA 433
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
380-608 |
2.01e-21 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 96.39 E-value: 2.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 380 EALQAER-ALREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRIDrNIERTDQMVRDLLDANRIQGGQRLP 458
Cdd:COG5807 137 KLLRSEKlSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEYFNIIIS-EIDRINTIITELLVLSKPKKFNFKK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 459 LRLDmcdlggvaqEVVEELIALHGDRFVLHAEERVRGIWS--------AEELRRALWNLGSNAIKYGAATEPITFTVTRA 530
Cdd:COG5807 216 LNLN---------DVLEDVIALLSTEAILKNISIKYDLADdepvingdKNQLKQVFINLIKNAIEAMETGGNITIKTYVE 286
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2111051364 531 GDRARASVHNRGPVIAPADLEHIFKPFTRTHsaQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLD 608
Cdd:COG5807 287 GDFVVISVKDEGIGIPEEVLEKIGEPFFTTK--EEGT----GLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPLY 358
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
375-609 |
4.46e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 97.35 E-value: 4.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 375 LREKIEalQAER--ALREqFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALrIDRNIERTDQMVRDLLDANRIQ 452
Cdd:PRK11360 377 LQRRVA--RQERlaALGE-LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSV-VLREVDRLNKVIDQLLEFSRPR 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 453 GGQRLPLRLdmcdlggvaQEVVEELIALHGD-------RFVLHAEERVRGIW-SAEELRRALWNLGSNAIKYGAATEPIT 524
Cdd:PRK11360 453 ESQWQPVSL---------NALVEEVLQLFQTagvqarvDFETELDNELPPIWaDPELLKQVLLNILINAVQAISARGKIR 523
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 525 FTVTRAGDRARA-SVHNRGPVIAPADLEHIFKPFTRTHsaQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTL 603
Cdd:PRK11360 524 IRTWQYSDGQVAvSIEDNGCGIDPELLKKIFDPFFTTK--AKGT----GLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
|
....*.
gi 2111051364 604 KLPLDA 609
Cdd:PRK11360 598 YLPINP 603
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
372-617 |
6.60e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 91.24 E-value: 6.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 372 YANLREKI--------EALQ-AERALREQ--FVSVLAHDLRGPLSAAkSGAQLLMRHPERLDQRRDLAlriDRNIERTDQ 440
Cdd:PRK15347 370 YDTLENKVaertqalaEAKQrAEQANKRKseHLTTISHEIRTPLNGV-LGALELLQNTPLTAEQMDLA---DTARQCTLS 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 441 M---VRDLLDANRIQGGQR---------LPLrLD--MCDLGGVAQEVVEELIALHGDRFVLHAE-ERVRgiwsaeeLRRA 505
Cdd:PRK15347 446 LlaiINNLLDFSRIESGQMtlsleetalLPL-LDqaMLTIQGPAQSKSLTLRTFVGAHVPLYLHlDSLR-------LRQI 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 506 LWNLGSNAIKYgaaTEP--ITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTskgwGLGLTLVWGCAQ 583
Cdd:PRK15347 518 LVNLLGNAVKF---TETggIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGT----GLGLTIASSLAK 590
|
250 260 270
....*....|....*....|....*....|....
gi 2111051364 584 AHGGTVTVQSDAATGTTFTLKLPLDArpYQPREP 617
Cdd:PRK15347 591 MMGGELTLFSTPGVGSCFSLVLPLNE--YAPPEP 622
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
502-607 |
1.22e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 78.69 E-value: 1.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEpITFTVTRAGD-----RARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLT 576
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGE-VTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 2111051364 577 LVWGCAQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
335-611 |
1.30e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 87.01 E-value: 1.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 335 GIMYVGLAEVREFTAREKARLLslgQQLSVHLDNA--KLYANLREKIEALQAER-ALREQFVSVLAHDLRGPLSAAKSGA 411
Cdd:PRK10490 610 GLLAVEPGNLRQLMIPEQQRLL---ETFTLLIANAleRLTLTASEEQARLASEReQLRNALLAALSHDLRTPLTVLFGQA 686
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 412 QLLM--------RHPERLDQrrdlalrIDRNIERTDQMVRDLLDANRIQ-GGQRLPLR-----------LDMCD--LGG- 468
Cdd:PRK10490 687 EILTldlasegsPHARQASE-------IRQQVLNTTRLVNNLLDMARIQsGGFNLRKEwltleevvgsaLQMLEpgLSGh 759
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 469 -VAQEVVEELIALHGDRFVLhaeERVrgiwsaeelrraLWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAP 547
Cdd:PRK10490 760 pINLSLPEPLTLIHVDGPLF---ERV------------LINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPP 824
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2111051364 548 ADLEHIFKPFTRTHsaQKGTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLDARP 611
Cdd:PRK10490 825 GQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETPP 886
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
372-615 |
2.30e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 84.84 E-value: 2.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 372 YANLREKIEALQAERALREQFVSV------LAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRIDRNIERTDQMVRDL 445
Cdd:PRK10364 214 YRRYLRSRQLLQDEMKRKEKLVALghlaagVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSEL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 446 LDANRiqgGQRLPLR-LDMCDLGGVAQEVVEELIALHGDRFVLHAEERVRGIWS-AEELRRALWNLGSNAIKYGAATEPI 523
Cdd:PRK10364 294 LELVK---PTHLALQaVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQAdPDRLTQVLLNLYLNAIQAIGQHGVI 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 524 TFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRThsaqkgTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTL 603
Cdd:PRK10364 371 SVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
250
....*....|..
gi 2111051364 604 KLPLDARPYQPR 615
Cdd:PRK10364 445 WLPVNITRRDPQ 456
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
348-606 |
2.49e-17 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 84.23 E-value: 2.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 348 TAREKARLLSLGQQLSVhldnaklyanLREKIEALQAERALREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDL 427
Cdd:PRK09303 120 SGRYSQELLQLSDELFV----------LRQENETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKP 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 428 ALR------IDRNIERTDQMVRDLLDANRIQGGQrLPLRLDMCDLGGVAQEVVEELIalhgDRFVLHAEERVRGIWS--- 498
Cdd:PRK09303 190 ALIeqlqdqARRQLEEIERLITDLLEVGRTRWEA-LRFNPQKLDLGSLCQEVILELE----KRWLAKSLEIQTDIPSdlp 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 499 -----AEELRRALWNLGSNAIKYGAATEPITFTVT-RAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQkGTSkGWG 572
Cdd:PRK09303 265 svyadQERIRQVLLNLLDNAIKYTPEGGTITLSMLhRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDE-GTE-GYG 342
|
250 260 270
....*....|....*....|....*....|....
gi 2111051364 573 LGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:PRK09303 343 IGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-607 |
4.04e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 77.09 E-value: 4.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTraGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGC 581
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PtsP |
COG3605 |
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; |
208-387 |
6.32e-17 |
|
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
Pssm-ID: 442824 [Multi-domain] Cd Length: 188 Bit Score: 79.17 E-value: 6.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 208 RYLRLLQKVANEALVDEDeasLRDHLKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASMNpASFP 287
Cdd:COG3605 1 EMLKALRRISEAVASALD---LDEALDRIVRRIAEALGVDVCSIYLLDPDGGRLELRATEGLNPEAVGKVRLPLG-EGLV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 288 GRVAAGGEetsTVL--DAETTPL-EVSQTLRQNGLRSLLGVRLPPHRALVGIMYVGLAEVREFTAREKARLLSLGQQLSV 364
Cdd:COG3605 77 GLVAERGE---PLNlaDAASHPRfKYFPETGEEGFRSFLGVPIIRRGRVLGVLVVQSREPREFTEEEVEFLVTLAAQLAE 153
|
170 180
....*....|....*....|...
gi 2111051364 365 HLDNAKLYANLREKIEALQAERA 387
Cdd:COG3605 154 AIANAELLGELRAALAELSLARE 176
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-607 |
4.85e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 73.90 E-value: 4.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYgaATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGC 581
Cdd:cd16949 1 LARALENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-607 |
6.42e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 73.61 E-value: 6.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 500 EELRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTskgwGLGLTLVW 579
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGT----GLGLSLSY 77
|
90 100
....*....|....*....|....*...
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
377-606 |
2.59e-15 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 78.66 E-value: 2.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 377 EKIEALQAERAlreQFVSVLAHDLRGPLSaaksgaQLLMRHPERLDQRR---DLALRIDRNIE---RTDQMVRDLLDANR 450
Cdd:PRK09835 253 ERIEDVFTRQS---NFSADIAHEIRTPIT------NLITQTEIALSQSRsqkELEDVLYSNLEeltRMAKMVSDMLFLAQ 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 451 IQGGQRLPLRLdMCDLGGVAQEVVEELIALHGDRFV-LHAEERVRGIW-SAEELRRALWNLGSNAIKYGAATEPITFTVT 528
Cdd:PRK09835 324 ADNNQLIPEKK-MLDLADEVGKVFDFFEAWAEERGVeLRFVGDPCQVAgDPLMLRRAISNLLSNALRYTPAGEAITVRCQ 402
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2111051364 529 RAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGGTVTVQSDaATGTTFTLKLP 606
Cdd:PRK09835 403 EVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVISLP 479
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
379-610 |
2.83e-15 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 78.44 E-value: 2.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 379 IEALqaERALREQ--FVSVLAHDLRGPLSAAKSGAQLLMRhpeRLDQRRDLAlRIDRNIERTDQMVRDLLDANRIQggQR 456
Cdd:PRK09470 233 VTAL--ERMMTSQqrLLSDISHELRTPLTRLQLATALLRR---RQGESKELE-RIETEAQRLDSMINDLLVLSRNQ--QK 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 457 LPLRLDMCDLGGVAQEVVE----ELIALHGDRFVLHAEERvrgiWS----AEELRRALWNLGSNAIKYGAATEPITFTVT 528
Cdd:PRK09470 305 NHLERETFKANSLWSEVLEdakfEAEQMGKSLTVSAPPGP----WPingnPNALASALENIVRNALRYSHTKIEVAFSVD 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 529 RagDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLD 608
Cdd:PRK09470 381 K--DGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLY 458
|
..
gi 2111051364 609 AR 610
Cdd:PRK09470 459 KR 460
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
379-609 |
3.16e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 78.03 E-value: 3.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 379 IEALQAERALREQFVSvlaHDLRGPLSAAKSGAQllMRHPErlDQRrdLALRIDRNIERTDQMVRDLLDanRIQGGQRLP 458
Cdd:PRK09467 222 IKQLEDDRTLLMAGVS---HDLRTPLTRIRLATE--MMSEE--DGY--LAESINKDIEECNAIIEQFID--YLRTGQEMP 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 459 LrlDMCDLGGVAQEVV------EELIALHgdrfvLHAEE-RVRGiwSAEELRRALWNLGSNAIKYGaaTEPITFTVTRAG 531
Cdd:PRK09467 291 M--EMADLNALLGEVIaaesgyEREIETA-----LQPGPiEVPM--NPIAIKRALANLVVNAARYG--NGWIKVSSGTEG 359
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2111051364 532 DRARASVHNRGPVIAPADLEHIFKPFTRTHSAQkgTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLDA 609
Cdd:PRK09467 360 KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSAR--GSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
209-610 |
9.35e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.43 E-value: 9.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 209 YLRLLQKVANEALVDEDEASLRDHLKEVLELVIEamgaqsGAVLLYEAEGEQLVTAAAAGLAseqlehyvasmnpasfpg 288
Cdd:COG3290 62 LLLLLLLAALLLKLLEEIARLVEEREAVLESIRE------GVIAVDRDGRITLINDAARRLL------------------ 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 289 RVAAGGEETSTVLDAETTPLEVSQTLRQNGlRSLLGVRLPPHRALVGIMYVglaevreFTAREKARLLSLGQQLSvhldn 368
Cdd:COG3290 118 GLDAIGRPIDEVLAEVLETGERDEEILLNG-RVLVVNRVPIRDDGRVVGAV-------ATFRDRTELERLEEELE----- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 369 aklyaNLREKIEALqaeRALReqfvsvlaHDLRGPLSAAKSGAQLlmrhpERLDQRRDLALRIDRNIERTDQMVRDLLDA 448
Cdd:COG3290 185 -----GVKELAEAL---RAQR--------HDFRNHLHTISGLLQL-----GEYDEALEYIDEISEELQELIDSLLSRIGN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 449 NRIQGgqrlplrLdmcdLGGVAQEVVEELIalhgdRFVLHAEERVRGIW-SAEELRRALWNLGSNAIKYGAATEP----I 523
Cdd:COG3290 244 PVLAA-------L----LLGKAARARERGI-----DLTIDIDSDLPDLPlSDTDLVTILGNLLDNAIEAVEKLPEeerrV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 524 TFTVTRAGDRARASVHNRGPVIAPADLEHIFkpftrthsaQKGTS----KGWGLGLTLVWGCAQAHGGTVTVQSDAATGT 599
Cdd:COG3290 308 ELSIRDDGDELVIEVEDSGPGIPEELLEKIF---------ERGFStklgEGRGLGLALVKQIVEKYGGTIEVESEEGEGT 378
|
410
....*....|.
gi 2111051364 600 TFTLKLPLDAR 610
Cdd:COG3290 379 VFTVRLPKEGE 389
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
1.69e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.40 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATepITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQkgTSKGWGLGLTLVWGC 581
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGW--VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
2.83e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 68.96 E-value: 2.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEP----ITFTVTRAGDRARA-SVHNRGPVIAPADLEHIFKPFTRThsaqkgTSKGWGLGLT 576
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDRAVTiSVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 2111051364 577 LVWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
343-616 |
7.02e-14 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 74.24 E-value: 7.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 343 EVREFTAREKARLLSL-GQQLSVHLDNAKLYANLREKIEALQAERALRE--------QFVSVLAHDLRGPLSAAKSGAQL 413
Cdd:COG5809 215 EVRFWTKDGRWRLLEAsGAPIKKNGEVDGIVIIFRDITERKKLEELLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 414 LMrhpERLDQRRDLALRI-DRNIERTDQMVRDLLDANRIQGGqrlplRLDMCDLggvaQEVVEELIAL-------HGDRF 485
Cdd:COG5809 295 LK---DTIDEEQKTYLDImLSELDRIESIISEFLVLAKPQAI-----KYEPKDL----NTLIEEVIPLlqpqallKNVQI 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 486 VLHAEERVRGIW-SAEELRRALWNLGSNAIKygAATEPITFTVTRA---GDRARASVHNRGPVIAPADLEHIFKPFTRTH 561
Cdd:COG5809 363 ELELEDDIPDILgDENQLKQVFINLLKNAIE--AMPEGGNITIETKaedDDKVVISVTDEGCGIPEERLKKLGEPFYTTK 440
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2111051364 562 SaqKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLDARPYQPRE 616
Cdd:COG5809 441 E--KGT----GLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVSMN 489
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
383-606 |
2.03e-12 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 69.27 E-value: 2.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 383 QAERALREQFVSVlAHDLRGPLSAAKsGAQLLMRHPERLDQRRDLALRIDR-NIERTDQMVRDLLDANRIQGGQRLPL-- 459
Cdd:PRK11006 199 QLEGARRNFFANV-SHELRTPLTVLQ-GYLEMMQDQPLEGALREKALHTMReQTQRMEGLVKQLLTLSKIEAAPTIDLne 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 460 RLDMCDLggvaQEVVE-ELIALHGDR----FVLHAEERVRGiwSAEELRRALWNLGSNAIKYGAATEPITFTVTRAGDRA 534
Cdd:PRK11006 277 KVDVPMM----LRVLErEAQTLSQGKhtitFEVDNSLKVFG--NEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2111051364 535 RASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:PRK11006 351 EFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
208-611 |
2.23e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 70.09 E-value: 2.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 208 RYLRLLQKVANEaLVDEDEASLRDHLKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASMNPAsfp 287
Cdd:PRK13837 274 AFEEVIAAISRC-FEAASPHELEASIEAALGILAKFFDADSAALALVDVGGRARIWTFPGLTPDPVWPDRLRALAST--- 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 288 grvaAGGEETSTVLDAETTPLEVSQTLRQNGLRSLLGVRLPPHRALVGIMyvGLAEVREFtAREKARLLSLGQQLSVHLD 367
Cdd:PRK13837 350 ----VKAAERDVVFVDRNGPVRKRSCLTRRGPALWACLAFKSGDRIVALL--GLGRQRYG-LRPPAGELQLLELALDCLA 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 368 NAKLYANLREKIEALQA--ERALREQ----FVSVLAHDLRGPLSAAKSGAQL----LMRHPERldqRRDLALrIDRNIER 437
Cdd:PRK13837 423 HAIERRRLETERDALERrlEHARRLEavgtLASGIAHNFNNILGAILGYAEMalnkLARHSRA---ARYIDE-IISAGAR 498
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 438 TDQMVRDLLDANRIQGGQRLPLrldmcDLGGVAQEVVEELIALHGDRFVL---HAEERVRGIWSAEELRRALWNLGSNAI 514
Cdd:PRK13837 499 ARLIIDQILAFGRKGERNTKPF-----DLSELVTEIAPLLRVSLPPGVELdfdQDQEPAVVEGNPAELQQVLMNLCSNAA 573
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 515 K---------------YGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAqkgtskGWGLGLTLVW 579
Cdd:PRK13837 574 QamdgagrvdislsraKLRAPKVLSHGVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAG------GTGLGLATVH 647
|
410 420 430
....*....|....*....|....*....|..
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKLPLDARP 611
Cdd:PRK13837 648 GIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKV 679
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-605 |
8.92e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.53 E-value: 8.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 500 EELRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVW 579
Cdd:cd16947 19 EALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITK 98
|
90 100
....*....|....*....|....*.
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKL 605
Cdd:cd16947 99 RLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
1.80e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.19 E-value: 1.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEP--ITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSaqKGTSKGWGLGLTLVW 579
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
3.55e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 60.09 E-value: 3.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKgtSKGWGLGLTLVWGC 581
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 2111051364 582 AQAHGGTVTVQSDaATGTTFTLKLP 606
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
396-607 |
3.55e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 65.91 E-value: 3.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 396 LAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRidrNIERTDQMVRDLLDANRIQGGQRlplrlDMCDLGGVAQEVVE 475
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLS---ELDRIESIISEFLALAKPQAVNK-----EKENINELIQDVVT 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 476 ELIA---LHGDRFVLHAEERVRGIW-SAEELRRALWNLGSNAIKygaATEP---ITFTVTRAGDRARASVHNRGPVIAPA 548
Cdd:COG5805 366 LLETeaiLHNIQIRLELLDEDPFIYcDENQIKQVFINLIKNAIE---AMPNggtITIHTEEEDNSVIIRVIDEGIGIPEE 442
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2111051364 549 DLEHIFKPFTRTHsaQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:COG5805 443 RLKKLGEPFFTTK--EKGT----GLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
380-617 |
5.78e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 65.70 E-value: 5.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 380 EALQAERAlREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLAlRIDRNIERTDQMVRDLLDANRIQGGQR--- 456
Cdd:PRK11466 436 EAEKASQA-KSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLR-AITDSGESLLTILNDILDYSAIEAGGKnvs 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 457 ------LPLRLDMCDLGGVAQEVVEELIALHGDrFVLHAEERVRGiwSAEELRRALWNLGSNAIKYgaaTEPITFTVTRA 530
Cdd:PRK11466 514 vsdepfEPRPLLESTLQLMSGRVKGRPIRLATD-IADDLPTALMG--DPRRIRQVITNLLSNALRF---TDEGSIVLRSR 587
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 531 GDRAR--ASVHNRGPVIAPADLEHIFKPFTRThSAQKGtskGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLD 608
Cdd:PRK11466 588 TDGEQwlVEVEDSGCGIDPAKLAEIFQPFVQV-SGKRG---GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
250
....*....|
gi 2111051364 609 -ARPYQPREP 617
Cdd:PRK11466 664 vATAPVPKTV 673
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
389-454 |
7.16e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.99 E-value: 7.16e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2111051364 389 REQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLAlRIDRNIERTDQMVRDLLDANRIQGG 454
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLE-TILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
499-606 |
8.31e-11 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 59.43 E-value: 8.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 499 AEELRRALWNLGSNAIKYGAATEPITFTVTRA-GDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTL 577
Cdd:cd16925 2 AEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSI 81
|
90 100
....*....|....*....|....*....
gi 2111051364 578 VWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16925 82 VKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
70-506 |
1.23e-10 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 64.44 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 70 AETIHRHQGEIIRLWSEQAARAASARGLDGPEFKNIMPVYLASLADEEGVPGALVHARPTHVETHVAARLRQGFNVAEVI 149
Cdd:COG2203 52 LLLERLTELRAAARLAAEAAEAALLLILLIDALVLLSLVATAGLVLELADLLLLLRLLALLVLLLVALALAEALAARLLD 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 150 EEFAILGRCIASMWANASPEARPSALDVERLFTKLHAASTAVSERFSRHLLEDEQTEKRYLRLLQKVANEALVDEDEASL 229
Cdd:COG2203 132 LLLLGLGGRLRGVVLRGLRSAALLLSRVDTDLVGQLAALAGLILDIARLLTQRARLELERLALLNEISQALRSALDLEEL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 230 rdhLKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASmnpASFPGRVAAGGE--ETSTVLDAETTP 307
Cdd:COG2203 212 ---LQRILELAGELLGADRGAILLVDEDGGELELVAAPGLPEEELGRLPLG---EGLAGRALRTGEpvVVNDASTDPRFA 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 308 LEVSQTLRQNGLRSLLGVRLPPHRALVGIMYVGLAEVREFTAREKARLLSLGQQLSVHLDNAKLYANLREKIEALQAERA 387
Cdd:COG2203 286 PSLRELLLALGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAIERARLYEALEAALAALLQELA 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 388 LREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRIDRNIERTDQMVRDLLDANRIQGGQRLPLRLDMCDLG 467
Cdd:COG2203 366 LLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEGLLLLDLLLLLLLLRRILLLRVLRRL 445
|
410 420 430
....*....|....*....|....*....|....*....
gi 2111051364 468 GVAQEVVEELIALHGDRFVLHAEERVRGIWSAEELRRAL 506
Cdd:COG2203 446 LLGDEEGLVLLLALAELELLEILELLVLLAVILLALALL 484
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
387-450 |
1.58e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.84 E-value: 1.58e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2111051364 387 ALREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRIDRNIERTDQMVRDLLDANR 450
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-605 |
4.08e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 57.08 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAI-KYGAATEP-ITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRThsaqKGTSKGWGLGLTLVW 579
Cdd:cd16976 1 IQQVLMNLLQNALdAMGKVENPrIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT----KPVGKGTGLGLSISY 76
|
90 100
....*....|....*....|....*.
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKL 605
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
389-454 |
1.55e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 54.11 E-value: 1.55e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2111051364 389 REQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLAlRIDRNIERTDQMVRDLLDANRIQGG 454
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLE-TILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
2.57e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 54.90 E-value: 2.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGC 581
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-605 |
4.91e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 54.33 E-value: 4.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTrAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAqkgTSKGWGLGLTLVWGC 581
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQ---NYGGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKL 605
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-592 |
7.21e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 53.62 E-value: 7.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPF---TRTHSAQKGTskgwGLGLTLV 578
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQKST----GLGLAFV 80
|
90
....*....|....
gi 2111051364 579 WGCAQAHGGTVTVQ 592
Cdd:cd16945 81 QEVAQLHGGRITLR 94
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
7.58e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 53.73 E-value: 7.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGA-ATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWG 580
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 2111051364 581 CAQAHGGTVTV----QSDAATGTTFTLKLP 606
Cdd:cd16953 81 IIEAHGGISVAenhnQPGQVIGARFTVQLP 110
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
502-606 |
7.85e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 53.92 E-value: 7.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNA---IKYGAATEPITFTVTRAgDRARASVHNRGP----VIAPAD---------LEHIFKPFTRThsaqK 565
Cdd:cd16919 1 LELAILNLAVNArdaMPEGGRLTIETSNQRVD-ADYALNYRDLIPgnyvCLEVSDtgsgmpaevLRRAFEPFFTT----K 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2111051364 566 GTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16919 76 EVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
376-608 |
1.23e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 58.21 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 376 REKIEALQAER-------ALREQFVSVLAHDLRGPLSAAKSGAQLLMRHPERLDQRRDLALRIDRNIERTDQMVRDLLDA 448
Cdd:PRK09959 692 RDLIHALEVERnkainatVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDV 771
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 449 NRIQGGQrLPLRLDMCDLGGVAQEVVEELIALHGDR---------FVLHAEERVrgiwSAEELRRALWNLGSNAIKYGA- 518
Cdd:PRK09959 772 DKIESGN-YQLQPQWVDIPTLVQNTCHSFGAIAASKsialscsstFPDHYLVKI----DPQAFKQVLSNLLSNALKFTTe 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 519 ATEPITFTVTRAGDR---ARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTskGWGLGLTLVWGCAQAHGGTVTVQSDA 595
Cdd:PRK09959 847 GAVKITTSLGHIDDNhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHP 924
|
250
....*....|...
gi 2111051364 596 ATGTTFTLKLPLD 608
Cdd:PRK09959 925 GIGTTFTITIPVE 937
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
502-617 |
1.96e-08 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 57.26 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEpITFTVTR-AGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSK-GWGLGLTLVW 579
Cdd:PRK11091 399 LRQILWNLISNAVKFTQQGG-VTVRVRYeEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSK 477
|
90 100 110
....*....|....*....|....*....|....*...
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKLPLDARPYQPREP 617
Cdd:PRK11091 478 RLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVEDA 515
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
511-606 |
5.83e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 51.13 E-value: 5.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 511 SNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKP-FTRT--HSAQKGTskgwGLGLTLVWGCAQAHGG 587
Cdd:cd16948 15 SNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKgFTGEngRNFQEST----GMGLYLVKKLCDKLGH 90
|
90
....*....|....*....
gi 2111051364 588 TVTVQSDAATGTTFTLKLP 606
Cdd:cd16948 91 KIDVESEVGEGTTFTITFP 109
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-606 |
1.14e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 50.15 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGC 581
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
380-606 |
5.23e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 52.28 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 380 EALQAERalreQFVSVLAHDLRGPLsaakSGAQLlmrHPERLDQRRdlALRIDRNIERTDQM---VRDLLDANRI----Q 452
Cdd:PRK10755 132 STLDQER----LFTADVAHELRTPL----AGIRL---HLELLEKQH--HIDVAPLIARLDQMmhtVEQLLQLARAgqsfS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 453 GGQRLPLRLdMCDLGGVAQEVVEELIALHGDRFVLH---AEERVRGiwSAEELRRALWNLGSNAIKYGAATEPITFTVTR 529
Cdd:PRK10755 199 SGHYQTVKL-LEDVILPSQDELSEMLEQRQQTLLLPesaADITVQG--DATLLRLLLRNLVENAHRYSPEGSTITIKLSQ 275
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2111051364 530 AGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTskgwGLGLTLVWGCAQAHGGTVTVQSDA-ATGTTFTLKLP 606
Cdd:PRK10755 276 EDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGI----GLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLP 349
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
388-590 |
6.66e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 51.96 E-value: 6.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 388 LRE-QFVSVLAHDLRGPLSAAK---SGAQLLMRHPerldQRRDLAL-RIDRNIERTDQMVRDLLDANRIQGGQrlplrld 462
Cdd:PRK10337 235 VRErRFTSDAAHELRSPLAALKvqtEVAQLSDDDP----QARKKALlQLHAGIDRATRLVDQLLTLSRLDSLD------- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 463 mcDLGGVAQEVVEELI----------ALHGD---RFVLHAEERVRgiwSAEELRRALW--NLGSNAIKYGAATEPITFTV 527
Cdd:PRK10337 304 --NLQDVAEIPLEDLLqsavmdiyhtAQQAGidvRLTLNAHPVIR---TGQPLLLSLLvrNLLDNAIRYSPQGSVVDVTL 378
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2111051364 528 TragdrARA-SVHNRGPVIAPADLEHIFKPFTRThSAQKGTskGWGLGLTLVWGCAQAHGGTVT 590
Cdd:PRK10337 379 N-----ARNfTVRDNGPGVTPEALARIGERFYRP-PGQEAT--GSGLGLSIVRRIAKLHGMNVS 434
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
521-608 |
1.27e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.21 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 521 EPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRThsaqKGTSKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTT 600
Cdd:PRK13557 312 DLAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTT----KEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTT 387
|
....*...
gi 2111051364 601 FTLKLPLD 608
Cdd:PRK13557 388 VRLYFPAS 395
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
332-610 |
2.43e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 49.23 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 332 ALVGIMYVGLAEVREFTAREKARLLSLGQQLSvhldnaklyanlREKIEALQAERAlReqfvsvLAHDLR----GPLSAA 407
Cdd:COG4585 12 LLVGALLGLLLALVLLRARRAERAAELERELA------------ARAEEAREEERR-R------IARELHdgvgQSLSAI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 408 KSGAQLLMRHPERLDQR-RDLALRIDRNIERTDQMVRDLLDANRiqggqrlPLRLDMCDLGGVAQEVVEELIALHGDRFV 486
Cdd:COG4585 73 KLQLEAARRLLDADPEAaREELEEIRELAREALAELRRLVRGLR-------PPALDDLGLAAALEELAERLLRAAGIRVE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 487 LHAEERVRGI--WSAEELRRALWNLGSNAIKYGAATEpITFTVTRAGDRARASVHNRGPVIAPADLehifkpftrthsaq 564
Cdd:COG4585 146 LDVDGDPDRLppEVELALYRIVQEALTNALKHAGATR-VTVTLEVDDGELTLTVRDDGVGFDPEAA-------------- 210
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2111051364 565 kgtsKGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLDAR 610
Cdd:COG4585 211 ----PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
508-611 |
2.86e-06 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 50.02 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 508 NLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGCAQAHGG 587
Cdd:PRK10549 359 NLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNG 438
|
90 100
....*....|....*....|....
gi 2111051364 588 TVTVQSDAATGTTFTLKLPLDARP 611
Cdd:PRK10549 439 RIIAAHSPFGGVSITVELPLERDL 462
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
508-606 |
3.74e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 45.74 E-value: 3.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 508 NLGSNAIKYGAATEP----ITFTVTRAGDRARASVHNRGPVIAPADLEHIFkpftrthsaQKGTS----KGWGLGLTLVW 579
Cdd:cd16915 7 NLIDNALDALAATGApnkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVF---------ERGVStkgqGERGIGLALVR 77
|
90 100
....*....|....*....|....*..
gi 2111051364 580 GCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:cd16915 78 QSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
542-610 |
5.06e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.53 E-value: 5.06e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2111051364 542 GPVIAPADLEHIFkpftrthsaQKGTS---KGWGLGLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLPLDAR 610
Cdd:PRK11086 476 GPGIAPDEIDAIF---------DKGYStkgSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGE 538
|
|
| GAF |
smart00065 |
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ... |
233-376 |
5.58e-06 |
|
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.
Pssm-ID: 214500 [Multi-domain] Cd Length: 149 Bit Score: 46.61 E-value: 5.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 233 LKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLE--HYVASMnpaSFPGRVAAGGEETsTVLDAETTPLEV 310
Cdd:smart00065 6 LQTILEELRQLLGADRVLIYLVDENDRGELVLVAADGLTLPTLgiRFPLDE---GLAGRVAETGRPL-NIPDVEADPLFA 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2111051364 311 SQTLRQN-GLRSLLGVRLPPHRALVGIMYVG-LAEVREFTAREKARLLSLGQQLSVHLDNAKLYANLR 376
Cdd:smart00065 82 EDLLGRYqGVRSFLAVPLVADGELVGVLALHnKKSPRPFTEEDEELLQALANQLAIALANAQLYEELR 149
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
502-617 |
3.15e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 47.28 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYgAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQKGTSKGWGLGLTLVWGC 581
Cdd:PRK10841 563 LQQVISNLLSNAIKF-TDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKL 641
|
90 100 110
....*....|....*....|....*....|....*.
gi 2111051364 582 AQAHGGTVTVQSDAATGTTFTLKLPLDARPYQPREP 617
Cdd:PRK10841 642 INMMDGDISVDSEPGMGSQFTIRIPLYGAQYPQKKG 677
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-604 |
1.22e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 41.68 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 502 LRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRTHSAQkgTSKG-WGLGLTLVWG 580
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR--RSGGhYGMGLYIAKN 82
|
90 100
....*....|....*....|....
gi 2111051364 581 CAQAHGGTVTVQSDAATGTTFTLK 604
Cdd:cd16975 83 LVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
358-606 |
1.49e-04 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 44.68 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 358 LGQQLSVHLDNAK-LYANLREKIEA-LQAERALRE---------------QFVSVLAHDLRGPLSAAK-----SGAQLLM 415
Cdd:COG4192 385 IARLLRVFRDQAIeKTQELETEIEErKRIEKNLRQtqdeliqaakmavvgQTMTSLAHELNQPLNAMSmylfsAKKALEQ 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 416 RHPERLdqrRDLALRIDRNIERTDQMVRDLLDANRiqggqRLPLRLDMCDLGGVAQEVVeELIALHGDR--FVLHAEERV 493
Cdd:COG4192 465 ENYAQL---PTSLDKIEGLIERMDKIIKSLRQFSR-----KSDTPLQPVDLRQVIEQAW-ELVESRAKPqqITLHIPDDL 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 494 RGIWSAEELRRALWNLGSNAIKYGAATEPITFTVTRAGDRARASVHNRGPviAPADLEHIFKPFTRTHSAqkgtskGWGL 573
Cdd:COG4192 536 MVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGN--GWPLVDKLFTPFTTTKEV------GLGL 607
|
250 260 270
....*....|....*....|....*....|...
gi 2111051364 574 GLTLVWGCAQAHGGTVTVQSDAATGTTFTLKLP 606
Cdd:COG4192 608 GLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
233-368 |
3.54e-04 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 40.82 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 233 LKEVLELVIEAMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASMNPAsfpgRVAAGGEETSTVLDAETTPLEvsq 312
Cdd:pfam13492 6 LEALLKLLVRLLGAERAAVYLLDEDGNKLQVAAGYDGEPDPSESLDADSPLA----RRALSSGEPISGLGSAGEDGL--- 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2111051364 313 tlrqnGLRSLLGVRLPPHRALVGIMYVGLAEVREFTAREKARLLSLGQQLSVHLDN 368
Cdd:pfam13492 79 -----PDGPALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIEN 129
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
434-607 |
3.78e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 43.47 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 434 NIERTDQMVRDLLDANRI---QGGQRLPLRLDMcdlggvaqEVVEELIAL----HGDRFVLH--AEERvrgIWSAEELRR 504
Cdd:COG2972 271 DPEEAEEMLEALSKLLRYslsKGDELVTLEEEL--------ELIKSYLEIqklrFGDRLEVEieIDEE---LLDLLIPKL 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 505 ALWNLGSNAIKYGAATEP----ITFTVTRAGDRARASVHNRGPVIAPADLEHIFKPFTRthsaqKGTSKGWGLG-----L 575
Cdd:COG2972 340 ILQPLVENAIEHGIEPKEgggtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSS-----KGEGRGIGLRnvrerL 414
|
170 180 190
....*....|....*....|....*....|..
gi 2111051364 576 TLVWGcaqaHGGTVTVQSDAATGTTFTLKLPL 607
Cdd:COG2972 415 KLYYG----EEYGLEIESEPGEGTTVTIRIPL 442
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
226-367 |
5.82e-04 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 40.53 E-value: 5.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 226 EASLRDHLKEVLELVIEaMGAQSGAVLLYEAEGEQLVTAAAAGLASEQLEHYVASMNPAsfpGRVAAGGEETsTVLDAET 305
Cdd:pfam13185 1 AADLEELLDAVLEAAVE-LGASAVGFILLVDDDGRLAAWGGAADELSAALDDPPGEGLV---GEALRTGRPV-IVNDLAA 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2111051364 306 TPLEVSQTLRQNGLRSLLGVRLPPHRALVGIMYVGLAEVREFTAREKARLLSLGQQLSVHLD 367
Cdd:pfam13185 76 DPAKKGLPAGHAGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
509-610 |
9.48e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.20 E-value: 9.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2111051364 509 LGSNAIKYGAATEP---ITFTVTRAGDRARASVHNRGPVIaPADLEhifkpftrthsaqkgTSKGWGLGLTLVWGCAQAH 585
Cdd:COG3920 407 LVTNALKHAFLSGEggrIRVSWRREDGRLRLTVSDNGVGL-PEDVD---------------PPARKGLGLRLIRALVRQL 470
|
90 100
....*....|....*....|....*
gi 2111051364 586 GGTVTVqsDAATGTTFTLKLPLDAR 610
Cdd:COG3920 471 GGTLEL--DRPEGTRVRITFPLAEL 493
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
534-606 |
1.24e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 38.92 E-value: 1.24e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2111051364 534 ARASVHNRGPVIAPADLEHIFKPFTrthsaqKGTSKGWGLGLTLVWGCAQAHGGTVTVQSdAATGTTFTLKLP 606
Cdd:cd16918 44 LRVSVIDNGPGIPPDLQDTIFYPMV------SGRENGTGLGLAIAQNIVSQHGGVIECDS-QPGHTVFSVSLP 109
|
|
| |
