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Conserved domains on  [gi|2102696118|ref|WP_223925123|]
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Xaa-Pro dipeptidase [Aeromonas caviae]

Protein Classification

aminopeptidase P family protein( domain architecture ID 11486751)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13607 PRK13607
proline dipeptidase; Provisional
 1-440 0e+00

proline dipeptidase; Provisional


:

Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 801.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118   1 MSSYSQLFAQHLDTLQQRTRDILQQQGLGGLAIHSGQTHRIFLDDQDYPFKVNPQFKAWLPVLDNPHCWLLVDGVNKPVL 80
Cdd:PRK13607    1 MESLASLYKEHIATLQQRTRDALAREGLDALLIHSGELHRVFLDDHDYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118  81 LFYRPVDFWHKVAELPNAFWIDFFDIRFLTRPEQVADHLPANKQEWAYLGGHLEVAELLGLGQP--NPEAVLNYLHYHRA 158
Cdd:PRK13607   81 WFYQPVDYWHNVEPLPESFWTEEVDIKALTKADGIASLLPADRGNVAYIGEVPERALALGFEASniNPKGVLDYLHYHRA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 159 YKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQGANEAPYGNIVAINRNAAILHYTHLstQRVPDA 238
Cdd:PRK13607  161 YKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFDINLAYLTATGQRDNDVPYGNIVALNEHAAVLHYTKL--DHQAPA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 239 ERYSFLIDAGVDVHGYASDITRTW-AWRRGEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMHHRLARLLQATELV-DM 316
Cdd:PRK13607  239 EMRSFLIDAGAEYNGYAADITRTYaAKEDNDFAALIKDVNKEQLALIATMKPGVSYVDLHIQMHQRIAKLLRKFQIVtGL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 317 SVDEMIHTGVTNVFFPHGLGHFLGLQVHDAGGFMQDERGTHLAAPEQFPYLRCTRVIEVGQVFTIEPGLYFIDSLLEPLR 396
Cdd:PRK13607  319 SEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGFMQDDRGTHLAAPEKHPYLRCTRVLEPGMVLTIEPGLYFIDSLLAPLR 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2102696118 397 QGEQGKRVNWNKVEVLRPYGGIRIEDNVVLHANGVENLTRQAGL 440
Cdd:PRK13607  399 EGPFSKHFNWQKIDALKPFGGIRIEDNVVVHENGVENMTRDLKL 442
 
Name Accession Description Interval E-value
PRK13607 PRK13607
proline dipeptidase; Provisional
 1-440 0e+00

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 801.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118   1 MSSYSQLFAQHLDTLQQRTRDILQQQGLGGLAIHSGQTHRIFLDDQDYPFKVNPQFKAWLPVLDNPHCWLLVDGVNKPVL 80
Cdd:PRK13607    1 MESLASLYKEHIATLQQRTRDALAREGLDALLIHSGELHRVFLDDHDYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118  81 LFYRPVDFWHKVAELPNAFWIDFFDIRFLTRPEQVADHLPANKQEWAYLGGHLEVAELLGLGQP--NPEAVLNYLHYHRA 158
Cdd:PRK13607   81 WFYQPVDYWHNVEPLPESFWTEEVDIKALTKADGIASLLPADRGNVAYIGEVPERALALGFEASniNPKGVLDYLHYHRA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 159 YKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQGANEAPYGNIVAINRNAAILHYTHLstQRVPDA 238
Cdd:PRK13607  161 YKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFDINLAYLTATGQRDNDVPYGNIVALNEHAAVLHYTKL--DHQAPA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 239 ERYSFLIDAGVDVHGYASDITRTW-AWRRGEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMHHRLARLLQATELV-DM 316
Cdd:PRK13607  239 EMRSFLIDAGAEYNGYAADITRTYaAKEDNDFAALIKDVNKEQLALIATMKPGVSYVDLHIQMHQRIAKLLRKFQIVtGL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 317 SVDEMIHTGVTNVFFPHGLGHFLGLQVHDAGGFMQDERGTHLAAPEQFPYLRCTRVIEVGQVFTIEPGLYFIDSLLEPLR 396
Cdd:PRK13607  319 SEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGFMQDDRGTHLAAPEKHPYLRCTRVLEPGMVLTIEPGLYFIDSLLAPLR 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2102696118 397 QGEQGKRVNWNKVEVLRPYGGIRIEDNVVLHANGVENLTRQAGL 440
Cdd:PRK13607  399 EGPFSKHFNWQKIDALKPFGGIRIEDNVVVHENGVENMTRDLKL 442
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 165-436 3.59e-82

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 252.88  E-value: 3.59e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 165 LECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQGANEAPYGNIVAINRNAAILHYTHLStQRVPDAErySFL 244
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGSNAAILHYVHND-QPLKDGD--LVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 245 IDAGVDVHGYASDITRTWA----WRrGEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMHHRLARLLQATELVDMSVDE 320
Cdd:cd01087    78 IDAGAEYGGYASDITRTFPvngkFT-DEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 321 MIHTGVTNVFFPHGLGHFLGLQVHDAGGFmqdergthlaapeqFPYLRCTRVIEVGQVFTIEPGLYFIDSLLEPlrqgeq 400
Cdd:cd01087   157 IVESGAYAKFFPHGLGHYLGLDVHDVGGY--------------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2102696118 401 gkrvnwnkvEVLRPYGGIRIEDNVVLHANGVENLTR 436
Cdd:cd01087   217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
145-436 1.38e-61

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 201.97  E-value: 1.38e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 145 NPEAVLNYLHYHRAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQ-GANEAPYGNIVAINRNAA 223
Cdd:COG0006    59 ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRrGAEGPSFDTIVASGENAA 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 224 ILHYTHlSTQRVPDAErySFLIDAGVDVHGYASDITRTWAWRR--GEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMH 301
Cdd:COG0006   139 IPHYTP-TDRPLKPGD--LVLIDAGAEYDGYTSDITRTVAVGEpsDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAAR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 302 HRLARLLQATelvdmsvdemihtgvtnvFFPHGLGHFLGLQVHDAGGFMQDErgthlaapeqfpylrcTRVIEVGQVFTI 381
Cdd:COG0006   216 DVLAEAGYGE------------------YFPHGTGHGVGLDVHEGPQISPGN----------------DRPLEPGMVFTI 261

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2102696118 382 EPGLYFIDslleplrqgeqgkrvnwnkvevlrpYGGIRIEDNVVLHANGVENLTR 436
Cdd:COG0006   262 EPGIYIPG-------------------------IGGVRIEDTVLVTEDGAEVLTR 291
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 166-428 1.32e-41

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 146.62  E-value: 1.32e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 166 ECLRDANRIGVRGHIAAKDSFMAGASEFEIN--LAYMKAVGQGANEAPYGNIVAINRNAAILHYTHlSTQRVPDAErySF 243
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAaeLEAARLRRGGARGPAFPPIVASGPNAAIPHYIP-NDRVLKPGD--LV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 244 LIDAGVDV-HGYASDITRTWAWRR--GEFADLIAALDAQQQEIIDEIKPGRRYSELHlqmhhRLARllqatelvdmsvDE 320
Cdd:pfam00557  78 LIDVGAEYdGGYCSDITRTFVVGKpsPEQRELYEAVLEAQEAAIAAVKPGVTGGDVD-----AAAR------------EV 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 321 MIHTGVTnVFFPHGLGHFLGLQVHDAGgfmqdergthlaapeQFPYLRCTRVIEVGQVFTIEPGLYFIDSlleplrqgeq 400
Cdd:pfam00557 141 LEEAGLG-EYFPHGLGHGIGLEVHEGP---------------YISRGGDDRVLEPGMVFTIEPGIYFIPG---------- 194

                         250       260
                  ....*....|....*....|....*...
gi 2102696118 401 gkrvnwnkvevlrpYGGIRIEDNVVLHA 428
Cdd:pfam00557 195 --------------WGGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
PRK13607 PRK13607
proline dipeptidase; Provisional
 1-440 0e+00

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 801.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118   1 MSSYSQLFAQHLDTLQQRTRDILQQQGLGGLAIHSGQTHRIFLDDQDYPFKVNPQFKAWLPVLDNPHCWLLVDGVNKPVL 80
Cdd:PRK13607    1 MESLASLYKEHIATLQQRTRDALAREGLDALLIHSGELHRVFLDDHDYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118  81 LFYRPVDFWHKVAELPNAFWIDFFDIRFLTRPEQVADHLPANKQEWAYLGGHLEVAELLGLGQP--NPEAVLNYLHYHRA 158
Cdd:PRK13607   81 WFYQPVDYWHNVEPLPESFWTEEVDIKALTKADGIASLLPADRGNVAYIGEVPERALALGFEASniNPKGVLDYLHYHRA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 159 YKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQGANEAPYGNIVAINRNAAILHYTHLstQRVPDA 238
Cdd:PRK13607  161 YKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFDINLAYLTATGQRDNDVPYGNIVALNEHAAVLHYTKL--DHQAPA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 239 ERYSFLIDAGVDVHGYASDITRTW-AWRRGEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMHHRLARLLQATELV-DM 316
Cdd:PRK13607  239 EMRSFLIDAGAEYNGYAADITRTYaAKEDNDFAALIKDVNKEQLALIATMKPGVSYVDLHIQMHQRIAKLLRKFQIVtGL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 317 SVDEMIHTGVTNVFFPHGLGHFLGLQVHDAGGFMQDERGTHLAAPEQFPYLRCTRVIEVGQVFTIEPGLYFIDSLLEPLR 396
Cdd:PRK13607  319 SEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGFMQDDRGTHLAAPEKHPYLRCTRVLEPGMVLTIEPGLYFIDSLLAPLR 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2102696118 397 QGEQGKRVNWNKVEVLRPYGGIRIEDNVVLHANGVENLTRQAGL 440
Cdd:PRK13607  399 EGPFSKHFNWQKIDALKPFGGIRIEDNVVVHENGVENMTRDLKL 442
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 165-436 3.59e-82

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 252.88  E-value: 3.59e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 165 LECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQGANEAPYGNIVAINRNAAILHYTHLStQRVPDAErySFL 244
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGSNAAILHYVHND-QPLKDGD--LVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 245 IDAGVDVHGYASDITRTWA----WRrGEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMHHRLARLLQATELVDMSVDE 320
Cdd:cd01087    78 IDAGAEYGGYASDITRTFPvngkFT-DEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 321 MIHTGVTNVFFPHGLGHFLGLQVHDAGGFmqdergthlaapeqFPYLRCTRVIEVGQVFTIEPGLYFIDSLLEPlrqgeq 400
Cdd:cd01087   157 IVESGAYAKFFPHGLGHYLGLDVHDVGGY--------------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2102696118 401 gkrvnwnkvEVLRPYGGIRIEDNVVLHANGVENLTR 436
Cdd:cd01087   217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
145-436 1.38e-61

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 201.97  E-value: 1.38e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 145 NPEAVLNYLHYHRAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQ-GANEAPYGNIVAINRNAA 223
Cdd:COG0006    59 ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRrGAEGPSFDTIVASGENAA 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 224 ILHYTHlSTQRVPDAErySFLIDAGVDVHGYASDITRTWAWRR--GEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMH 301
Cdd:COG0006   139 IPHYTP-TDRPLKPGD--LVLIDAGAEYDGYTSDITRTVAVGEpsDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAAR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 302 HRLARLLQATelvdmsvdemihtgvtnvFFPHGLGHFLGLQVHDAGGFMQDErgthlaapeqfpylrcTRVIEVGQVFTI 381
Cdd:COG0006   216 DVLAEAGYGE------------------YFPHGTGHGVGLDVHEGPQISPGN----------------DRPLEPGMVFTI 261

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2102696118 382 EPGLYFIDslleplrqgeqgkrvnwnkvevlrpYGGIRIEDNVVLHANGVENLTR 436
Cdd:COG0006   262 EPGIYIPG-------------------------IGGVRIEDTVLVTEDGAEVLTR 291
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 166-428 1.32e-41

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 146.62  E-value: 1.32e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 166 ECLRDANRIGVRGHIAAKDSFMAGASEFEIN--LAYMKAVGQGANEAPYGNIVAINRNAAILHYTHlSTQRVPDAErySF 243
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAaeLEAARLRRGGARGPAFPPIVASGPNAAIPHYIP-NDRVLKPGD--LV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 244 LIDAGVDV-HGYASDITRTWAWRR--GEFADLIAALDAQQQEIIDEIKPGRRYSELHlqmhhRLARllqatelvdmsvDE 320
Cdd:pfam00557  78 LIDVGAEYdGGYCSDITRTFVVGKpsPEQRELYEAVLEAQEAAIAAVKPGVTGGDVD-----AAAR------------EV 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 321 MIHTGVTnVFFPHGLGHFLGLQVHDAGgfmqdergthlaapeQFPYLRCTRVIEVGQVFTIEPGLYFIDSlleplrqgeq 400
Cdd:pfam00557 141 LEEAGLG-EYFPHGLGHGIGLEVHEGP---------------YISRGGDDRVLEPGMVFTIEPGIYFIPG---------- 194

                         250       260
                  ....*....|....*....|....*...
gi 2102696118 401 gkrvnwnkvevlrpYGGIRIEDNVVLHA 428
Cdd:pfam00557 195 --------------WGGVRIEDTVLVTE 208
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 152-435 9.42e-30

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 120.21  E-value: 9.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 152 YLHYHRAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEF----EINLAYMKavgQGANEAPYGNIVAINRNAAILHY 227
Cdd:PRK10879  166 WVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYqlegEIHHEFNR---HGARYPSYNTIVGSGENGCILHY 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 228 THlSTQRVPDAERysFLIDAGVDVHGYASDITRTWAwRRGEFAdliaaldAQQQEIIDEI-----------KPGRRYSEL 296
Cdd:PRK10879  243 TE-NESEMRDGDL--VLIDAGCEYKGYAGDITRTFP-VNGKFT-------PAQREIYDIVlesletslrlyRPGTSIREV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 297 HLQmhhrLARLLqATELVDM-----SVDEMIHTGVTNVFFPHGLGHFLGLQVHDAGGFMQDErgthlaapeqfpylrcTR 371
Cdd:PRK10879  312 TGE----VVRIM-VSGLVKLgilkgDVDQLIAENAHRPFFMHGLSHWLGLDVHDVGVYGQDR----------------SR 370

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2102696118 372 VIEVGQVFTIEPGLYfidslLEPlrqgeqgkrvnwnKVEVLRPYGGI--RIEDNVVLHANGVENLT 435
Cdd:PRK10879  371 ILEPGMVLTVEPGLY-----IAP-------------DADVPEQYRGIgiRIEDDIVITETGNENLT 418
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 165-430 2.08e-27

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 108.37  E-value: 2.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 165 LECLRDANRIGVRGHIAAKDSFMAGASEFEI--NLAY-MKAvgQGANEAPYGNIVAINRNAAILHYTHlSTQRVPDAEry 241
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMTEREVaaELEYfMRK--LGAEGPSFDTIVASGPNSALPHGVP-SDRKIEEGD-- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 242 SFLIDAGVDVHGYASDITRTWAWrrGEFADLIAA-----LDAqQQEIIDEIKPGRRYSELhlqmhHRLARllqatelvdm 316
Cdd:cd01092    76 LVLIDFGAIYDGYCSDITRTVAV--GEPSDELKEiyeivLEA-QQAAIKAVKPGVTAKEV-----DKAAR---------- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 317 svdemihtgvtNV--------FFPHGLGHFLGLQVHDAGGFMQDErgthlaapeqfpylrcTRVIEVGQVFTIEPGLYFi 388
Cdd:cd01092   138 -----------DVieeagygeYFIHRTGHGVGLEVHEAPYISPGS----------------DDVLEEGMVFTIEPGIYI- 189

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2102696118 389 dslleplrqgeQGKrvnwnkvevlrpyGGIRIEDNVVLHANG 430
Cdd:cd01092   190 -----------PGK-------------GGVRIEDDVLVTEDG 207
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 165-430 4.11e-26

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 104.84  E-value: 4.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 165 LECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVGQGANEAPYGNIVAINRNAAILHYTHlSTQRVPDAERYsfL 244
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAGPTIVGSGARTALPHYRP-DDRRLQEGDLV--L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 245 IDAGVDVHGYASDITRTWAW--RRGEFADLIAALDAQQQEIIDEIKPGRRYSELHLQMHHRLARLLQATElvdmsvdemi 322
Cdd:cd01066    78 VDLGGVYDGYHADLTRTFVIgePSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPN---------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 323 htgvtnvfFPHGLGHFLGLQVHDAGGFMQDErgthlaapeqfpylrcTRVIEVGQVFTIEPGLYFIDSlleplrqgeqgk 402
Cdd:cd01066   148 --------FGHRTGHGIGLEIHEPPVLKAGD----------------DTVLEPGMVFAVEPGLYLPGG------------ 191

                         250       260
                  ....*....|....*....|....*...
gi 2102696118 403 rvnwnkvevlrpyGGIRIEDNVVLHANG 430
Cdd:cd01066   192 -------------GGVRIEDTVLVTEDG 206
PRK09795 PRK09795
aminopeptidase; Provisional
 157-434 5.78e-14

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 73.05  E-value: 5.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 157 RAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLA---YMKAvgQGANEAPYGNIVAINRNAAILHyTHLSTQ 233
Cdd:PRK09795  125 RQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAElewFMRQ--QGAEKASFDTIVASGWRGALPH-GKASDK 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 234 RVPDAERYSflIDAGVDVHGYASDITRTWaWRRGE---------FADLIAALDAQQQEIiDEIKPGRRYSElhlqmhhrl 304
Cdd:PRK09795  202 IVAAGEFVT--LDFGALYQGYCSDMTRTL-LVNGEgvsaeshplFNVYQIVLQAQLAAI-SAIRPGVRCQQ--------- 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 305 arllqatelVDMSVDEMIHTGVTNVFFPHGLGHFLGLQVHDAGGFMQDErGTHLAApeqfpylrctrvievGQVFTIEPG 384
Cdd:PRK09795  269 ---------VDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRFSPRD-TTTLQP---------------GMLLTVEPG 323

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2102696118 385 LYfidslleplrqgeqgkrvnwnkvevLRPYGGIRIEDNVVLHANGVENL 434
Cdd:PRK09795  324 IY-------------------------LPGQGGVRIEDVVLVTPQGAEVL 348
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 215-426 1.42e-06

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 49.10  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 215 IVAINRNAAILHYTHLS-TQRVPDAERYsFLIDAGVDVHGYASDITRTWAWrrGEfadliaaLDAQQQeiideikpgRRY 293
Cdd:cd01085    57 ISGFGPNGAIVHYSPTEeSNRKISPDGL-YLIDSGGQYLDGTTDITRTVHL--GE-------PTAEQK---------RDY 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 294 SeLHLQMHHRLARL-----LQATELvDMSV-----DEMI---H-TGvtnvffpHGLGHFLGlqVHDA-GGFMQDERGTHL 358
Cdd:cd01085   118 T-LVLKGHIALARAkfpkgTTGSQL-DALArqplwKAGLdygHgTG-------HGVGSFLN--VHEGpQSISPAPNNVPL 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2102696118 359 AApeqfpylrctrvievGQVFTIEPGLYfidslleplRQGEqgkrvnwnkvevlrpyGGIRIEdNVVL 426
Cdd:cd01085   187 KA---------------GMILSNEPGYY---------KEGK----------------YGIRIE-NLVL 213
PRK14576 PRK14576
putative endopeptidase; Provisional
 157-342 3.16e-05

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 46.16  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 157 RAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVgQGANEAPYG--NIVAINRNAAILHYTHLSTQR 234
Cdd:PRK14576  175 RMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAV-MSFPETNFSrfNLISVGDNFSPKIIADTTPAK 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 235 VPDAERYsfliDAGVDVHGYASDITRTWawrrgefadLIAALDAQQQEIIDEIKPGrryselHLQMHHRLARLLQATELV 314
Cdd:PRK14576  254 VGDLIKF----DCGIDVAGYGADLARTF---------VLGEPDKLTQQIYDTIRTG------HEHMLSMVAPGVKLKAVF 314

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2102696118 315 DMSVDEMIHTGVTNV---FFPHGLGHFLGLQ 342
Cdd:PRK14576  315 DSTMAVIKTSGLPHYnrgHLGHGDGVFLGLE 345
PRK15173 PRK15173
peptidase; Provisional
 157-342 4.30e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 45.48  E-value: 4.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 157 RAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVgQGANEAPYGNIVAINRNAAILHYTHLSTQRVP 236
Cdd:PRK15173   93 RVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAV-MSKSETHFSRFHLISVGADFSPKLIPSNTKAC 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 237 DAERYSFliDAGVDVHGYASDITRTWAwrRGEFADLiaaldaqQQEIIDEIKPGrryselHLQMHHRLARLLQATELVDM 316
Cdd:PRK15173  172 SGDLIKF--DCGVDVDGYGADIARTFV--VGEPPEI-------TRKIYQTIRTG------HEHMLSMVAPGVKMKDVFDS 234

                         170       180
                  ....*....|....*....|....*....
gi 2102696118 317 SVDEMIHTGVTNV---FFPHGLGHFLGLQ 342
Cdd:PRK15173  235 TMEVIKKSGLPNYnrgHLGHGNGVFLGLE 263
PRK14575 PRK14575
putative peptidase; Provisional
 157-342 6.74e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 45.08  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 157 RAYKTPYELECLRDANRIGVRGHIAAKDSFMAGASEFEINLAYMKAVgQGANEAPYGNIVAINRNAAILHYTHLSTQRVP 236
Cdd:PRK14575  176 RVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAV-MSKSETHFSRFHLISVGADFSPKLIPSNTKAC 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102696118 237 DAERYSFliDAGVDVHGYASDITRTWAwrRGEFADLiaaldaqQQEIIDEIKPGrryselHLQMHHRLARLLQATELVDM 316
Cdd:PRK14575  255 SGDLIKF--DCGVDVDGYGADIARTFV--VGEPPEI-------TRKIYQTIRTG------HEHMLSMVAPGVKMKDVFDS 317

                         170       180
                  ....*....|....*....|....*....
gi 2102696118 317 SVDEMIHTGVTNV---FFPHGLGHFLGLQ 342
Cdd:PRK14575  318 TMEVIKKSGLPNYnrgHLGHGNGVFLGLE 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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