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Conserved domains on  [gi|2084886474|ref|WP_221552479|]
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MdtB/MuxB family multidrug efflux RND transporter permease subunit [Enterobacter sp. RIT637]

Protein Classification

multidrug transporter subunit MdtB( domain architecture ID 11484747)

multidrug transporter subunit MdtB is a component of the MdtABC tripartite complex that confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


:

Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 2023.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474    1 MQVMPPGSTGGPSRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQF 80
Cdd:PRK10503     1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   81 GQMSGLKQMSSQSSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAMPM 160
Cdd:PRK10503    81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  161 TQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSA 240
Cdd:PRK10503   161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  241 NDQMQSADEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESL 320
Cdd:PRK10503   241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  321 PKSVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMA 400
Cdd:PRK10503   321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
Cdd:PRK10503   401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  481 LISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKG 560
Cdd:PRK10503   481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  561 FFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTNPSLNSARLQINLKPLDDRDDRVNAV 640
Cdd:PRK10503   561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  641 IERLQNAVARVPGVELYLQPIQDLTIDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYV 720
Cdd:PRK10503   641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  721 NVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEE 800
Cdd:PRK10503   721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  801 RYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIV 880
Cdd:PRK10503   801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  881 LGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQA 960
Cdd:PRK10503   881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDRLALWAKSRFPKREEEA 1040
Cdd:PRK10503   961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
 
Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 2023.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474    1 MQVMPPGSTGGPSRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQF 80
Cdd:PRK10503     1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   81 GQMSGLKQMSSQSSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAMPM 160
Cdd:PRK10503    81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  161 TQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSA 240
Cdd:PRK10503   161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  241 NDQMQSADEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESL 320
Cdd:PRK10503   241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  321 PKSVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMA 400
Cdd:PRK10503   321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
Cdd:PRK10503   401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  481 LISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKG 560
Cdd:PRK10503   481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  561 FFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTNPSLNSARLQINLKPLDDRDDRVNAV 640
Cdd:PRK10503   561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  641 IERLQNAVARVPGVELYLQPIQDLTIDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYV 720
Cdd:PRK10503   641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  721 NVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEE 800
Cdd:PRK10503   721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  801 RYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIV 880
Cdd:PRK10503   801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  881 LGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQA 960
Cdd:PRK10503   881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDRLALWAKSRFPKREEEA 1040
Cdd:PRK10503   961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
13-1024 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1390.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAMPMTQVEDMVETRVA 172
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  173 QKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADEYRQ 252
Cdd:NF033617   161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  253 LIIAYQ-NGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSD 331
Cdd:NF033617   241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  332 RTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDD 411
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  412 AIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLT 491
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  492 PMMCARMLSHESlrKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNGIIQ 571
Cdd:NF033617   481 PMMCSRLLKANE--KPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  572 GTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVdGTNPSLNSARLQINLKPLDDRDDRVNAVIERLQNAVARV 651
Cdd:NF033617   559 GMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV-GGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  652 PGVELYLQPIQDLTIDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVNVNRDTASRLG 731
Cdd:NF033617   638 PGMDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLG 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  732 ITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEERYTPLSINHLD 811
Cdd:NF033617   718 ISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFN 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  812 QFPSTTISFNVPDGYSLGEAVESILSAEKELsFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVLGVLYESFIHP 891
Cdd:NF033617   798 QFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  892 ITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILMT 971
Cdd:NF033617   877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2084886474  972 TLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDR 1024
Cdd:NF033617   957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
12-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1157.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   12 PSRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSS 91
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   92 QSSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSS--AMPMTQVEDMVET 169
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  170 RVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADE 249
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  250 YRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVL 329
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  330 SDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVV 409
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  410 DDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSL 488
Cdd:pfam00873  400 DDAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  489 TLTPMMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNG 568
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  569 IIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGV--DGTNPSLNSARLQINLKPLDDR---DDRVNAVIER 643
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafSGDNNGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  644 LQNAVARVPGVELYLQPIQDLTID--TQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVN 721
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGLgtISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  722 VNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEER 801
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  802 YTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVL 881
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  882 GVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQAC 961
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2084886474  962 LLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFD 1023
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
13-1028 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1143.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSSAMPMTQVEDMVETRVA 172
Cdd:COG0841     84 SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIK 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  173 QKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADEYRQ 252
Cdd:COG0841    163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  253 LIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSDR 332
Cdd:COG0841    243 IVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYDQ 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  333 TTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDA 412
Cdd:COG0841    323 SEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  413 IVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTP 492
Cdd:COG0841    403 IVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTP 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  493 MMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNGIIQG 572
Cdd:COG0841    483 ALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIV 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  573 TLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTNPSLNSARLQINLKPLDDRDDRVNAVIERLQNAVARVP 652
Cdd:COG0841    563 SVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIP 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  653 GVELYLQPIQDltiDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVNVNRDTASRLGI 732
Cdd:COG0841    643 GARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGV 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  733 TMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEERYTPLSINHLDQ 812
Cdd:COG0841    720 TVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  813 FPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVLGVLYESFIHPI 892
Cdd:COG0841    800 QRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  893 TILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALaAEREQGMSPRDAIFQACLLRFRPILMTT 972
Cdd:COG0841    880 IILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN-QLREEGMSLREAILEAARLRLRPILMTS 958
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2084886474  973 LAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDRLALW 1028
Cdd:COG0841    959 LATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRR 1014
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
13-1025 4.49e-176

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 542.01  E-value: 4.49e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSS 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSG-GASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVysKVNPA-DPPIMTLAVTSSAMPMTQVE--DMVE 168
Cdd:TIGR00915   82 SDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGV--RVEKAsSNFLMVIGLVSDDGSMTKEDlsDYAA 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  169 TRVAQKISQVSGVGLVTLAGGQRpAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSL------DGPTRAVTLSAND 242
Cdd:TIGR00915  160 SNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQT 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  243 QMQSADEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLP 321
Cdd:TIGR00915  239 RLQTPEQFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  322 KSVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMAL 401
Cdd:TIGR00915  319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  402 TIATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
Cdd:TIGR00915  399 VLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  481 LISAVVSLTLTPMMCARML------SHESLRKqnRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLW 554
Cdd:TIGR00915  479 ALSVLVALILTPALCATMLkpiekgEHHEKKG--GFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLF 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  555 IFIPKGFFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPA--VESLTAYVGVDGTNPSLNSARLQINLKPLDD 632
Cdd:TIGR00915  557 VRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanVESVFTVNGFSFAGRGQNMGMAFIRLKDWEE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  633 RD---DRVNAVIERLQNAVARVP---GVELYLQPIQDLTidtqvSRTQYQFTLQA---TTLDALSTWVPQLVDKLKALPQ 703
Cdd:TIGR00915  637 RTgkeNSVFAIAGRATGHFMQIKdamVIAFVPPAILELG-----NATGFDFFLQDragLGHEALLQARNQLLGLAAQNPA 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  704 LSDVSSDWQDKGLAAYVNVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLT 783
Cdd:TIGR00915  712 LTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVR 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  784 SKDGGIVPLSAIASVEERYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELsfPSDIQTQFQGSTLAFQAAL 863
Cdd:TIGR00915  792 NASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQKL--PPGFGFSWTGMSYEERLSG 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  864 GNTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFAl 943
Cdd:TIGR00915  870 SQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFA- 948
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  944 AAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFD 1023
Cdd:TIGR00915  949 KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVR 1028

                   ..
gi 2084886474 1024 RL 1025
Cdd:TIGR00915 1029 RL 1030
 
Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 2023.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474    1 MQVMPPGSTGGPSRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQF 80
Cdd:PRK10503     1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   81 GQMSGLKQMSSQSSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAMPM 160
Cdd:PRK10503    81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  161 TQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSA 240
Cdd:PRK10503   161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  241 NDQMQSADEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESL 320
Cdd:PRK10503   241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  321 PKSVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMA 400
Cdd:PRK10503   321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
Cdd:PRK10503   401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  481 LISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKG 560
Cdd:PRK10503   481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  561 FFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTNPSLNSARLQINLKPLDDRDDRVNAV 640
Cdd:PRK10503   561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  641 IERLQNAVARVPGVELYLQPIQDLTIDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYV 720
Cdd:PRK10503   641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  721 NVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEE 800
Cdd:PRK10503   721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  801 RYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIV 880
Cdd:PRK10503   801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  881 LGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQA 960
Cdd:PRK10503   881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDRLALWAKSRFPKREEEA 1040
Cdd:PRK10503   961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
13-1024 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1390.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAMPMTQVEDMVETRVA 172
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  173 QKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADEYRQ 252
Cdd:NF033617   161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  253 LIIAYQ-NGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSD 331
Cdd:NF033617   241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  332 RTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDD 411
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  412 AIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLT 491
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  492 PMMCARMLSHESlrKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNGIIQ 571
Cdd:NF033617   481 PMMCSRLLKANE--KPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  572 GTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVdGTNPSLNSARLQINLKPLDDRDDRVNAVIERLQNAVARV 651
Cdd:NF033617   559 GMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV-GGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  652 PGVELYLQPIQDLTIDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVNVNRDTASRLG 731
Cdd:NF033617   638 PGMDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLG 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  732 ITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEERYTPLSINHLD 811
Cdd:NF033617   718 ISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFN 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  812 QFPSTTISFNVPDGYSLGEAVESILSAEKELsFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVLGVLYESFIHP 891
Cdd:NF033617   798 QFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  892 ITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILMT 971
Cdd:NF033617   877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2084886474  972 TLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDR 1024
Cdd:NF033617   957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
12-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1157.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   12 PSRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSS 91
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   92 QSSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSS--AMPMTQVEDMVET 169
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  170 RVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADE 249
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  250 YRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVL 329
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  330 SDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVV 409
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  410 DDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSL 488
Cdd:pfam00873  400 DDAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  489 TLTPMMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNG 568
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  569 IIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGV--DGTNPSLNSARLQINLKPLDDR---DDRVNAVIER 643
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafSGDNNGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  644 LQNAVARVPGVELYLQPIQDLTID--TQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVN 721
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGLgtISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  722 VNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEER 801
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  802 YTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVL 881
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  882 GVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQAC 961
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2084886474  962 LLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFD 1023
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
13-1028 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1143.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSSAMPMTQVEDMVETRVA 172
Cdd:COG0841     84 SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIK 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  173 QKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADEYRQ 252
Cdd:COG0841    163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  253 LIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSDR 332
Cdd:COG0841    243 IVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYDQ 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  333 TTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDA 412
Cdd:COG0841    323 SEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  413 IVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTP 492
Cdd:COG0841    403 IVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTP 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  493 MMCARMLSHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNGIIQG 572
Cdd:COG0841    483 ALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIV 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  573 TLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTNPSLNSARLQINLKPLDDRDDRVNAVIERLQNAVARVP 652
Cdd:COG0841    563 SVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIP 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  653 GVELYLQPIQDltiDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVNVNRDTASRLGI 732
Cdd:COG0841    643 GARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGV 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  733 TMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEERYTPLSINHLDQ 812
Cdd:COG0841    720 TVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  813 FPSTTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVLGVLYESFIHPI 892
Cdd:COG0841    800 QRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  893 TILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALaAEREQGMSPRDAIFQACLLRFRPILMTT 972
Cdd:COG0841    880 IILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN-QLREEGMSLREAILEAARLRLRPILMTS 958
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2084886474  973 LAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDRLALW 1028
Cdd:COG0841    959 LATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRR 1014
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
15-1025 0e+00

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 1075.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   15 LFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSS 94
Cdd:PRK10614     6 LFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSS 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   95 GGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAMPMTQVEDMVETRVAQK 174
Cdd:PRK10614    86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFASTQLAQT 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  175 ISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADEYRQLI 254
Cdd:PRK10614   166 ISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLI 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  255 IAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSDRTT 334
Cdd:PRK10614   246 IHYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSP 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  335 NIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIV 414
Cdd:PRK10614   326 TIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIV 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  415 VIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMM 494
Cdd:PRK10614   406 VLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMM 485
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  495 CARMLSHESLRKQNRfSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNGIIQGTL 574
Cdd:PRK10614   486 CAWLLKSSKPREQKR-LRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRLMGFI 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  575 QAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTnpslNSARLQINLKPLDDRDDRVNAVIERLQNAVARVPGV 654
Cdd:PRK10614   565 QADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRV----NSGMMFITLKPLSERSETAQQVIDRLRVKLAKEPGA 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  655 ELYLQPIQDLTIDTQVSRTQYQFTLQATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVNVNRDTASRLGITM 734
Cdd:PRK10614   641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  735 SDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKDGGIVPLSAIASVEERYTPLSINHLDQFP 814
Cdd:PRK10614   721 QAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  815 STTISFNVPDGYSLGEAVESILSAEKELSFPSDIQTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVLGVLYESFIHPITI 894
Cdd:PRK10614   801 ASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTI 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  895 LSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILMTTLA 974
Cdd:PRK10614   881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLA 960
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2084886474  975 ALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDRL 1025
Cdd:PRK10614   961 ALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL 1011
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
13-1025 4.49e-176

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 542.01  E-value: 4.49e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSS 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSG-GASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVysKVNPA-DPPIMTLAVTSSAMPMTQVE--DMVE 168
Cdd:TIGR00915   82 SDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGV--RVEKAsSNFLMVIGLVSDDGSMTKEDlsDYAA 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  169 TRVAQKISQVSGVGLVTLAGGQRpAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSL------DGPTRAVTLSAND 242
Cdd:TIGR00915  160 SNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQT 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  243 QMQSADEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLP 321
Cdd:TIGR00915  239 RLQTPEQFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  322 KSVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMAL 401
Cdd:TIGR00915  319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  402 TIATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
Cdd:TIGR00915  399 VLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  481 LISAVVSLTLTPMMCARML------SHESLRKqnRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLW 554
Cdd:TIGR00915  479 ALSVLVALILTPALCATMLkpiekgEHHEKKG--GFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLF 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  555 IFIPKGFFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPA--VESLTAYVGVDGTNPSLNSARLQINLKPLDD 632
Cdd:TIGR00915  557 VRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanVESVFTVNGFSFAGRGQNMGMAFIRLKDWEE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  633 RD---DRVNAVIERLQNAVARVP---GVELYLQPIQDLTidtqvSRTQYQFTLQA---TTLDALSTWVPQLVDKLKALPQ 703
Cdd:TIGR00915  637 RTgkeNSVFAIAGRATGHFMQIKdamVIAFVPPAILELG-----NATGFDFFLQDragLGHEALLQARNQLLGLAAQNPA 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  704 LSDVSSDWQDKGLAAYVNVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLT 783
Cdd:TIGR00915  712 LTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVR 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  784 SKDGGIVPLSAIASVEERYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELsfPSDIQTQFQGSTLAFQAAL 863
Cdd:TIGR00915  792 NASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQKL--PPGFGFSWTGMSYEERLSG 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  864 GNTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFAl 943
Cdd:TIGR00915  870 SQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFA- 948
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  944 AAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFD 1023
Cdd:TIGR00915  949 KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVR 1028

                   ..
gi 2084886474 1024 RL 1025
Cdd:TIGR00915 1029 RL 1030
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
14-1024 4.38e-147

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 465.27  E-value: 4.38e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   14 RLFILrpvattLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQS 93
Cdd:COG3696     13 RLLVL------LLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSIS 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   94 SGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDlpnppvyskVNPA-DPP------IMTLAVTSSAMPMTQVE-- 164
Cdd:COG3696     87 RFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAG---------VTPElGPIstglgeIYQYTLESDPGKYSLMElr 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  165 DMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQM 244
Cdd:COG3696    158 TLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLI 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  245 QSADEYRQLIIAYQNGAPIRLGDVATVEQGAENSwLGA--WANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPK 322
Cdd:COG3696    238 RSLEDIENIVVKTRNGTPVLLRDVAEVRIGPAPR-RGAatLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  323 SVSVKVLSDRTTNIRASVtDTQFE-LMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMAL 401
Cdd:COG3696    317 GVKIVPFYDRSDLIDRAI-HTVTKnLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGL 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  402 TIATGFVVDDAIVVIENISRYIEK------GEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVT 475
Cdd:COG3696    396 AIDFGIIVDGAVVMVENILRRLEEnraagtPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALT 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  476 LAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRasermfeRIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWI 555
Cdd:COG3696    476 VIFALLGALLLSLTLVPVLASLLLRGKVPEKENPLVR-------WLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFP 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  556 FIPKGFFPIQDNG--IIQGTLqaPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGV--DGTNP-SLNSARLQINLKPL 630
Cdd:COG3696    549 RLGSEFLPELDEGdlLVMATL--PPGISLEESVELGQQVERILKSFPEVESVVSRTGRaeDATDPmGVNMSETFVILKPR 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  631 DDRDDRVN--AVIERLQNAVARVPGVEL-YLQPIQDlTIDTQVS--RTQYQFTLQATTLDALSTWVPQLVDKLKALPQLS 705
Cdd:COG3696    627 SEWRSGRTkeELIAEMREALEQIPGVNFnFSQPIQM-RVDELLSgvRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAA 705
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  706 DVSSDwQDKGLAAY-VNVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVL---EHNTDNtpgLAALDSVR 781
Cdd:COG3696    706 DVQVE-RVTGLPQLdIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVrlpEELRDD---PEAIRNLP 781
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  782 LTSKDGGIVPLSAIASVEERYTPLSINHLDQFPSTTISFNVpDGYSLGEAVESILSA-EKELSFPSDIQTQFQGSTLAFQ 860
Cdd:COG3696    782 IPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANV-RGRDLGSFVAEAQAKvAEQVKLPPGYYIEWGGQFENLQ 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  861 AALGNTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLAGSEL--------------DVIaiigiil 926
Cdd:COG3696    861 RATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLsvsagvgfialfgvAVL------- 933
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  927 ligivkkNAIMMIDFALAAeREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLV 1006
Cdd:COG3696    934 -------NGVVLVSYINQL-RAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLIT 1005
                         1050
                   ....*....|....*...
gi 2084886474 1007 SQVLTLFTTPVIYLLFDR 1024
Cdd:COG3696   1006 STLLTLLVLPALYLLFGR 1023
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
15-1024 2.08e-138

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 442.35  E-value: 2.08e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   15 LFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSS 94
Cdd:PRK09579     6 PFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSR 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   95 GGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPpVYSKVNPADPPIMTLAVTSSAMPMTQVEDMVETRVAQK 174
Cdd:PRK09579    86 QNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDP-VLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQPK 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  175 ISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQSADEYRQLI 254
Cdd:PRK09579   165 LATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAFAAIP 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  255 IAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSDRTT 334
Cdd:PRK09579   245 VKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAYDATL 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  335 NIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIV 414
Cdd:PRK09579   325 FIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVDDAIV 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  415 VIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMM 494
Cdd:PRK09579   405 VVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTLSPMM 484
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  495 CARMLSHEslRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIPKGFFPIQDNGIIQGTL 574
Cdd:PRK09579   485 CALLLRHE--ENPSGLAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELAPEEDQGIIFMMS 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  575 QAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVDGTNPSLNSarlqINLKPLDDRDDRVNAVIERLQNAVARVPGV 654
Cdd:PRK09579   563 SSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGG----FLLKPWNERERTQMELLPLVQAKLEEIPGL 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  655 ELYLQPIQDLTIDTQvsRTQYQFTLQ-ATTLDALSTWVPQLVDKLKALPQLSDVSSDWQDKGLAAYVNVNRDTASRLGIT 733
Cdd:PRK09579   639 QIFGFNLPSLPGTGE--GLPFQFVINtANDYESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVS 716
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  734 MSDVDNALYNAFGQRLISTIYTQANQYRVV--LEHNTDNTPGLaaLDSVRLTSKDGGIVPLSAIASVEERYTPLSINHLD 811
Cdd:PRK09579   717 MQDLGGTLATLLGEGEINRFTIDGRSYKVIaqVERPYRDNPGW--LNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQ 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  812 QFPSTTISfNVPDgYSLGEAVESILSAEKELSfPSDIQTQFQGSTLAFQAAlGNTVWLIVAAVVAM-YIVLGVLYESFIH 890
Cdd:PRK09579   795 QLNSAIIS-GFPI-VSMGEAIETVQQIAREEA-PEGFAFDYAGASRQYVQE-GSALWVTFGLALAIiFLVLAAQFESFRD 870
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  891 PITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILM 970
Cdd:PRK09579   871 PLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRREAIEEAAAIRLRPVLM 950
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2084886474  971 TTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDR 1024
Cdd:PRK09579   951 TTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAK 1004
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
13-1037 1.38e-130

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 421.93  E-value: 1.38e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:PRK10555     2 ANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQ 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSG-GASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKvNPADPPIMTLAVTSS--AMPMTQVEDMVET 169
Cdd:PRK10555    82 SSGtGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVR-KTGDTNILTIAFVSTdgSMDKQDIADYVAS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  170 RVAQKISQVSGVGLVTLAGGQRpAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDG----PTRAV--TLSANDQ 243
Cdd:PRK10555   161 NIQDPLSRVNGVGDIDAYGSQY-SMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGtpsvDKQALnaTINAQSL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  244 MQSADEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPK 322
Cdd:PRK10555   240 LQTPEQFRDITLrVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPH 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  323 SVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALT 402
Cdd:PRK10555   320 GLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  403 IATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAIL 481
Cdd:PRK10555   400 LAIGLLVDDAIVVVENVERIMsEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMV 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  482 ISAVVSLTLTPMMCARML---SHESLRKQNRFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFIP 558
Cdd:PRK10555   480 LSVLVAMILTPALCATLLkplKKGEHHGQKGFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLGGMVFLFLRLP 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  559 KGFFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPA--VESLTAYVGVDGTNPSLNSARLQINLKPLDDRDDR 636
Cdd:PRK10555   560 TSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKdnVMSVFATVGSGPGGNGQNVARMFIRLKDWDERDSK 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  637 VN---AVIERLQNAVARVPGVELYLQpiQDLTIDTQVSRTQYQFTLQ---ATTLDALSTWVPQLVDKLKALPQLSDVSSD 710
Cdd:PRK10555   640 TGtsfAIIERATKAFNKIKEARVIAS--SPPAISGLGSSAGFDMELQdhaGAGHDALMAARNQLLALAAKNPELTRVRHN 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  711 WQDKGLAAYVNVNRDTASRLGITMSDVDNALYNAFGQRLIS---------TIYTQAN-QYRVVlehntdntPGLAALDSV 780
Cdd:PRK10555   718 GLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNdfmdrgrvkKVYVQAAaPYRML--------PDDINLWYV 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  781 RltSKDGGIVPLSAIASVEERYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELsfPSDIQTQFQGSTLAFQ 860
Cdd:PRK10555   790 R--NKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQL--PNGFGLEWTAMSYQER 865
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  861 AALGNTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMID 940
Cdd:PRK10555   866 LSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVE 945
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  941 FAlAAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYL 1020
Cdd:PRK10555   946 FA-NEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFFV 1024
                         1050
                   ....*....|....*..
gi 2084886474 1021 LFDRlalwaksRFPKRE 1037
Cdd:PRK10555  1025 LVRR-------RFPLKP 1034
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
13-1025 5.80e-128

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 414.63  E-value: 5.80e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:PRK09577     2 ARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSAT 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 SSGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVYSKvNPADPPIMTLAVTSSAMPMTQVE--DMVETR 170
Cdd:PRK09577    82 SSAGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVE-KAADNIQLIVSLTSDDGRLTGVElgEYASAN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  171 VAQKISQVSGVGLVTLAGGQRpAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSL------DGPTRAVTLSANDQM 244
Cdd:PRK09577   161 VLQALRRVEGVGKVQFWGAEY-AMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIgrsavpDSAPIAATVFADAPL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  245 QSADEYRQLIIAYQ-NGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKS 323
Cdd:PRK09577   240 KTPEDFGAIALRARaDGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPG 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  324 VSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTI 403
Cdd:PRK09577   320 VKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVL 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  404 ATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILI 482
Cdd:PRK09577   400 AIGILVDDAIVVVENVERLMvEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  483 SAVVSLTLTPMMCARMLS-----HESLRKqnrFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWIFI 557
Cdd:PRK09577   480 SAFLALSLTPALCATLLKpvdgdHHEKRG---FFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRL 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  558 PKGFFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIMKDPAVESLTAYVGVD--GTNPslNSARLQINLKPLDDR-- 633
Cdd:PRK09577   557 PTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNlyGEGP--NGGMIFVTLKDWKERka 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  634 -DDRVNAVIERLQNAVARVPGVELY---LQPIQDLTidtqvSRTQYQFTLQ---ATTLDALSTWVPQLVDKLKALPQLSD 706
Cdd:PRK09577   635 aRDHVQAIVARINERFAGTPNTTVFamnSPALPDLG-----STSGFDFRLQdrgGLGYAAFVAAREQLLAEGAKDPALTD 709
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  707 VSSDWQDKGLAAYVNVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSKD 786
Cdd:PRK09577   710 LMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQ 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  787 GGIVPLSAIASVEERYTPLSINHLDQFPSTTISFNVPDGYSLGEAVESILSAEKELsfPSDIQTQFQGSTLAFQAALGNT 866
Cdd:PRK09577   790 GEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAATL--PAGIGYAWSGQSFEERLSGAQA 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  867 VWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFA--LA 944
Cdd:PRK09577   868 PMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAkdLV 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  945 AereQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFDR 1024
Cdd:PRK09577   948 A---QRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFFVVVGR 1024

                   .
gi 2084886474 1025 L 1025
Cdd:PRK09577  1025 L 1025
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
13-1039 9.15e-117

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 385.03  E-value: 9.15e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   13 SRLFILRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQ 92
Cdd:PRK15127     2 PNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSN 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   93 S-SGGASVVTLQFQLTLSLDVAEQEVQAAINAATNLLPSDLPNPPVySKVNPADPPIMTLAVTSSAMPMTQ--VEDMVET 169
Cdd:PRK15127    82 SdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGV-SVEKSSSSFLMVVGVINTDGTMTQedISDYVAA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  170 RVAQKISQVSGVGLVTLAGGQRpAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDG--PTRAVTLSAN----DQ 243
Cdd:PRK15127   161 NMKDPISRTSGVGDVQLFGSQY-AMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGtpPVKGQQLNASiiaqTR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  244 MQSADEYRQLIIAY-QNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPK 322
Cdd:PRK15127   240 LTSTEEFGKILLKVnQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPS 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  323 SVSVKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALT 402
Cdd:PRK15127   320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  403 IATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAIL 481
Cdd:PRK15127   400 LAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  482 ISAVVSLTLTPMMCARML------SHESLRKQnrFSRASERMFERIIAAYGRVLAKVLNHPWATLGVALGTLALSVMLWI 555
Cdd:PRK15127   480 LSVLVALILTPALCATMLkpiakgDHGEGKKG--FFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFV 557
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  556 FIPKGFFPIQDNGIIQGTLQAPQSVSFANMAQRQQQVSEIIM--KDPAVESLTAYVGVDGTNPSLNSARLQINLKPLDDR 633
Cdd:PRK15127   558 RLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLtkEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADR 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  634 ---DDRVNAVIERLQNAVARVPGVELY---LQPIQDLTIDTQVSrtqYQFTLQATT-LDALSTWVPQLVDKLKALPQ-LS 705
Cdd:PRK15127   638 pgeENKVEAITMRATRAFSQIKDAMVFafnLPAIVELGTATGFD---FELIDQAGLgHEKLTQARNQLLGEAAKHPDmLV 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  706 DVSSDWQDKGLAAYVNVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVLEHNTDNTPGLAALDSVRLTSK 785
Cdd:PRK15127   715 GVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAA 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  786 DGGIVPLSAIASVEERYTPLSINHLDQFPSTTISFNVPDGYSLGEAVEsiLSAEKELSFPSDIQTQFQGstLAFQAAL-G 864
Cdd:PRK15127   795 DGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAME--LMEELASKLPTGVGYDWTG--MSYQERLsG 870
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  865 NTVWLIVA-AVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKNAIMMIDFAL 943
Cdd:PRK15127   871 NQAPALYAiSLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAK 950
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  944 AAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFTTPVIYLLFD 1023
Cdd:PRK15127   951 DLMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVR 1030
                         1050
                   ....*....|....*.
gi 2084886474 1024 RlalwaksRFPKREEE 1039
Cdd:PRK15127  1031 R-------RFSRKNED 1039
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
25-1024 1.78e-95

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 326.72  E-value: 1.78e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474   25 LLMVAILLAGIIG---YRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSSGGASVVT 101
Cdd:TIGR00914   15 LVLLATLVMAILGiwsYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQVT 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  102 LQFQLTLSLDVAEQEVQAAINAATNLLPSDlpnppvyskVNPADPPIMT----------LAVTSSAMPMTQVEDMVETRV 171
Cdd:TIGR00914   95 VIFKDGTDLYFARQLVNERLQQARDNLPEG---------VSPEMGPISTglgeiflytvEAEEGARKKDGGAYTLTDLRT 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  172 AQ------KISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAISNANVNSAKGSLDGPTRAVTLSANDQMQ 245
Cdd:TIGR00914  166 IQdwiirpQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQ 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  246 SADEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVS 325
Cdd:TIGR00914  246 SMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEGVE 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  326 VKVLSDRTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALtiAT 405
Cdd:TIGR00914  326 IVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DF 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  406 GFVVDDAIVVIENISRYIEKGEKPLAAALK----------GAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVT 475
Cdd:TIGR00914  404 GLIVDGAVVIVENAHRRLAEAQHHHGRQLTlkerlhevfaASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFT 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  476 LAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERmferiiaAYGRVLAKVLNHPWATLGVALGTLALSVMLWI 555
Cdd:TIGR00914  484 VVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMRVLKR-------RYEPLLERVLAWPAVVLGAAAVSIVLVVWIAS 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  556 FIPKGFFPIQDNG-IIQGTLQAPqSVSFANMAQRQQQVSEIIMKDPAVESL-----TAYVGVDGTNPslNSARLQINLKP 629
Cdd:TIGR00914  557 RVGGEFIPSLNEGdLAYQALRIP-GTSLAQSVAMQQTLEKLIKSFPEVARVfaktgTAEIATDPMPP--NASDTYIILKP 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  630 LDDRDDRVN---AVIERLQNAVARVPG-VELYLQPIQdLTIDTQVS--RTQYQFTLQATTLDALSTWVPQLVDKLKALPQ 703
Cdd:TIGR00914  634 ESQWPEGKKtkeDLIEEIQEATVRIPGnNYEFTQPIQ-MRFNELISgvRSDVAVKVFGDDLDDLDATAEKISAVLKGVPG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  704 LSDVSSDWQDKGLAAYVNVNRDTASRLGITMSDVDNALYNAFGQRLISTIYTQANQYRVVL---EHNTDNTPGLAALDSV 780
Cdd:TIGR00914  713 AADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIrlpESLRESPQALRQLPIP 792
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  781 RLTSKDGGI--VPLSAIASVEERYTPLSINHLDQFPSTTISFNVpDGYSLGEAVESILSA-EKELSFPSDIQTQFQGSTL 857
Cdd:TIGR00914  793 LPLSEDARKqfIPLSDVADLRVSPGPNQISRENGKRRVVVSANV-RGRDLGSFVDDAKKAiAEQVKLPPGYWITWGGQFE 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  858 AFQAAlgnTVWLIVAAVVAMYIVLGVLYESF---IHPITILSTLPTAGVGALLALMLAGSELDVIAIIGIILLIGIVKKN 934
Cdd:TIGR00914  872 QLQSA---TKRLQIVVPVTLLLIFVLLYAAFgnvKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLN 948
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  935 AIMMIDFaLAAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLLVSQVLTLFT 1014
Cdd:TIGR00914  949 GLVMISF-IRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFV 1027
                         1050
                   ....*....|
gi 2084886474 1015 TPVIYLLFDR 1024
Cdd:TIGR00914 1028 LPALYRLVHR 1037
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
332-563 2.34e-18

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 90.69  E-value: 2.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  332 RTTNIRASVTDTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDD 411
Cdd:COG1033    209 RGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDY 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  412 AIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMgDIvgRLFREFAVTLAVAILISAVVSLTLT 491
Cdd:COG1033    289 GIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFS-DI--PPIRDFGIVAAIGVLLAFLTSLTLL 365
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2084886474  492 PMmcarMLSHESLRKQNRFSRASERMFERIIAAYGRVlakVLNHPWATLGVALGTLALSVMLWIFI-----PKGFFP 563
Cdd:COG1033    366 PA----LLSLLPRPKPKTRRLKKPPELGRLLAKLARF---VLRRPKVILVVALVLAVVSLYGISRLkveydFEDYLP 435
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
290-492 5.11e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.90  E-value: 5.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  290 IVMNVQRQPGANIIDTADSIRTMLPQLIESLPKSVSVKVLSDRTTNIRASVTDTQFE-LMLAIALVVMIIYLFLRNVPAT 368
Cdd:COG1033    553 VTVRLKDLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRsLLLALLLIFLLLLLAFRSLRLG 632
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  369 IIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLT 448
Cdd:COG1033    633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTS 712
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2084886474  449 FSLIAVLIPLLFmGDIVGrlFREFAVTLAVAILISAVVSLTLTP 492
Cdd:COG1033    713 LTLAAGFGVLLF-SSFPP--LADFGLLLALGLLVALLAALLLLP 753
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
349-658 7.40e-10

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 62.86  E-value: 7.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  349 LAIALVVMIIylFLRNVPATIIPAVAVPLSLVGTFAVMVFL-------DFSINNLTLMALTIATgfvvDDAIVVIeniSR 421
Cdd:COG2409    179 LPVALVVLLL--VFRSLVAALLPLLTAGLAVGVALGLLALLaaftdvsSFAPNLLTMLGLGVGI----DYALFLV---SR 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  422 Y---IEKGEKPLAA---ALKGAGEI----GFTIIsltfslIAvLIPLLFMGDivgRLFREFAVTLAVAILISAVVSLTLT 491
Cdd:COG2409    250 YreeLRAGEDREEAvarAVATAGRAvlfsGLTVA------IA-LLGLLLAGL---PFLRSMGPAAAIGVAVAVLAALTLL 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  492 PMMCArMLSHESLRKQNRFSRASERMFERIiaaYGRVLAKVLNHPWATLGVALGTL------ALSVMLWI----FIPKGF 561
Cdd:COG2409    320 PALLA-LLGRRVFWPRRPRRRRAAAPESGF---WRRLARAVVRRPVPVLVAAVAVLlalalpALGLRLGLpdadSLPADS 395
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  562 ------------FPIQDNGIIQGTLQAPQSVSFANMAQrQQQVSEIIMKDPAVESLTAYVGVDGTNPslNSARLQINLKp 629
Cdd:COG2409    396 psrqgydalaehFPPGSNGPLTVVVESDDDLDPADLAA-LDALAAALAAVPGVASVQPPTRPEGTDG--DAARLQVVPD- 471
                          330       340       350
                   ....*....|....*....|....*....|
gi 2084886474  630 LDDRDDRVNAVIERLQNAVA-RVPGVELYL 658
Cdd:COG2409    472 GDPDSPEAIDLVDRLRDAAApALEGAEVLV 501
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
303-496 4.91e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 53.06  E-value: 4.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  303 IDTADSIRTMLPQLIESLPKSVSVKVLSDRTTNIRASVT-DTQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVG 381
Cdd:pfam03176  103 DESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGDrDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGA 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  382 TFAVMVFL----DFSINNLT---LMALTIATGfvVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIislTFSLIAV 454
Cdd:pfam03176  183 AQGLVAILahilGIGLSTFAlnlLVVLLIAVG--TDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVV---TAAGLTV 257
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2084886474  455 LIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCA 496
Cdd:pfam03176  258 AIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLA 299
secD PRK05812
preprotein translocase subunit SecD; Reviewed
319-514 8.58e-07

preprotein translocase subunit SecD; Reviewed


Pssm-ID: 235615 [Multi-domain]  Cd Length: 462  Bit Score: 52.53  E-value: 8.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  319 SLPksVSVKVLSDRT-------TNIRASVtdtqFELMLAIALVV--MIIY--LFlrnvpaTIIPAVAVPLSLVGTFAVMV 387
Cdd:PRK05812   274 ALP--APLEIVEERTigpslgaDSIRAGL----IAGLIGLALVLlfMILYyrLF------GLIANIALVANLVLILAVLS 341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  388 FLDFSinnLTL-----MALTIatGFVVDdAIVVI-ENISRYIEKGEKPLAAAlkgagEIGF-----TIIS--LTfSLIAV 454
Cdd:PRK05812   342 LLGAT---LTLpgiagIVLTI--GMAVD-ANVLIfERIREELREGRSLRSAI-----EAGFkrafsTILDsnIT-TLIAA 409
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  455 LIpLLFMGdiVGrLFREFAVTLAVAILISAVVSLTLTpmmcaRMLSHESLRKQNRFSRAS 514
Cdd:PRK05812   410 II-LYALG--TG-PVKGFAVTLGIGILTSMFTAITVT-----RALVNLLYGRRKRLKKLS 460
SecD COG0342
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ...
319-506 9.55e-07

Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440111 [Multi-domain]  Cd Length: 434  Bit Score: 52.42  E-value: 9.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  319 SLPksVSVKVLSDRT-------TNIRASVtdtqFELMLAIALVVMIIYLFLRnvpatiIPAVAVPLSLVG----TFAVMV 387
Cdd:COG0342    248 ALP--APLEIVEERTvgptlgaDSIEKGL----IAGLIGLLLVALFMLLYYR------LPGLVANIALALnvvlLLGVLS 315
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  388 FLDFsinNLTL-----MALTIATGfvVDDAIVVIENISRYIEKGeKPLAAALkgagEIGF-----TIIS--LTfSLIAVL 455
Cdd:COG0342    316 LLGA---TLTLpgiagIILTIGMA--VDANVLIFERIREELRAG-RSLRAAI----EAGFkrafsTILDanVT-TLIAAV 384
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2084886474  456 IpLLFMGdiVGRLfREFAVTLAVAILISAVVSLTLTPMMCARMLSHESLRK 506
Cdd:COG0342    385 V-LFVLG--TGPV-KGFAVTLILGILISMFTAVPVTRPLLNLLLGRRRLKK 431
2A0604s01 TIGR00916
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ...
283-488 1.05e-06

protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273336 [Multi-domain]  Cd Length: 192  Bit Score: 50.33  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  283 WANKQQAIVMNVQRQPGANIIdTADSIRTMLPQLIESLpksvsvkvlsdrttnIRASVtdtqfeLMLAIALVVMIIYLFL 362
Cdd:TIGR00916    9 FADFAANIGKPAIVLDNAKVI-SAPVVGTVGPTLGGEL---------------IKAGI------IALLIGLVLVLLYMLL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  363 RNVPATIIPAVAVPLS-LVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGE-KPLAAALkgagEI 440
Cdd:TIGR00916   67 RYEWRGAIAAIAALVHdVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVVIFDRIREELRKYKgRTFREAI----NL 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2084886474  441 GF------TIISLTFSLIAVLIPLLFMGDIVgrlfREFAVTLAVAILISAVVSL 488
Cdd:TIGR00916  143 GInqtlsrIIDTNVTTLLAVLALYVFGGGAI----KGFALTLGIGVIAGTYSSI 192
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
319-491 1.08e-05

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 49.21  E-value: 1.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  319 SLPksVSVKVLSDRTT-------NIRASVtdtqfeLMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDF 391
Cdd:TIGR01129  225 ALP--APLQILEERTIgpslgadSIEAGI------KAGLIGLVLVLVFMILYYRLFGLIAAIALVINIVLILAILSAFGA 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  392 SinnLTL-----MALTIatGFVVDDAIVVIENISRYIEKGEKPLAAAlkgagEIGF-----TIIS--LTfSLIAVLIPLL 459
Cdd:TIGR01129  297 T---LTLpgiagLILTI--GMAVDANVLIYERIKEELRLGKSVRQAI-----EAGFerafsTIFDanIT-TLIAALILYV 365
                          170       180       190
                   ....*....|....*....|....*....|...
gi 2084886474  460 F-MGDIVGrlfreFAVTLAVAILISAVVSLTLT 491
Cdd:TIGR01129  366 FgTGPVKG-----FAVTLAIGIIASLFTALVFT 393
PRK12911 PRK12911
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
343-510 9.67e-05

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 171815 [Multi-domain]  Cd Length: 1403  Bit Score: 46.78  E-value: 9.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  343 TQFELMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENIsry 422
Cdd:PRK12911   909 TQGIISVCLGLAVLIVLMSVYYRFGGVIASGAVLLNLLLIWAALQYLDAPLTLSGLAGIVLAMGMAVDANVLVFERI--- 985
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  423 ieKGEKPLAAALKGAGEIG----FTII---SLTFSLIAVLIPLLFMGDIVGrlfreFAVTLAVAILISAVVSLTLTP--- 492
Cdd:PRK12911   986 --REEYLLSRSLSESVEAGykkaFSAIfdsNLTTILASALLLMLDTGPIKG-----FALTLIIGIFSSMFTALFMTKfff 1058
                          170
                   ....*....|....*...
gi 2084886474  493 MMCARMLSHESLRKQNRF 510
Cdd:PRK12911  1059 MIWMNKTQETQLHMMNKF 1076
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
347-550 1.04e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 46.37  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  347 LMLAIALVVMIIYLFLRNVPATIIPAVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKG 426
Cdd:TIGR00921  199 MAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIG 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  427 EKPLAAALKGAGEIGFTIIsltFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPmmcARMLSHESLRK 506
Cdd:TIGR00921  279 RAKGEAIVTAVRRTGRAVL---IALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLP---ALLQSIDIGRE 352
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2084886474  507 QNRFSRASERMFERIIA-AYGRVLAKVLNHPWATLGVALGTLALS 550
Cdd:TIGR00921  353 KVKKEIIAIGGKSSEIEeELSKVLSITVRHPVPALVAALIITGLG 397
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
319-500 1.43e-03

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 42.53  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  319 SLPksVSVKVLSDRTTN-------IRASVtdtqFELMLAIALVVMIIYLFLRnvPATIIPAVAVPLSLVGTFAVMVFLDF 391
Cdd:PRK13024   243 ALP--APLKIIESRSVGptlgqdaIDAGI----IAGIIGFALIFLFMLVYYG--LPGLIANIALLLYIFLTLGALSSLGA 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  392 SINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTII--SLTfSLIAVLIplLFM---GDIvg 466
Cdd:PRK13024   315 VLTLPGIAGLVLGIGMAVDANVLIFERIKEELRKGKSLKKAFKKGFKNAFSTILdsNIT-TLIAAAI--LFFfgtGPV-- 389
                          170       180       190
                   ....*....|....*....|....*....|....
gi 2084886474  467 rlfREFAVTLAVAILISAVVSLTLTPMMCARMLS 500
Cdd:PRK13024   390 ---KGFATTLIIGILASLFTAVFLTRLLLELLVK 420
SecD_SecF pfam02355
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ...
349-482 7.56e-03

Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.


Pssm-ID: 280510 [Multi-domain]  Cd Length: 189  Bit Score: 38.74  E-value: 7.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  349 LAIALVVMIIYLFLRNVPATIIPAVAVPLS-LVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENI-SRYIEKG 426
Cdd:pfam02355   37 LLFALLLILIYVGLRFEWRFALGAIIALAHdVIITVGVFSLFGIEVDLATVAALLTIIGYSVNDTVVVFDRVrENLRKKT 116
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2084886474  427 EKPLAAALKGAGEIGF--TIISLTFSLIAVLIPLLFMGDIVgrlfREFAVTLAVAILI 482
Cdd:pfam02355  117 RATLNEIMNLSINQTLtrTINTSLTTLLVVVALFVFGGGSL----KDFSLALLVGVIV 170
PRK14726 PRK14726
protein translocase subunit SecDF;
347-501 8.41e-03

protein translocase subunit SecDF;


Pssm-ID: 237805 [Multi-domain]  Cd Length: 855  Bit Score: 40.09  E-value: 8.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  347 LMLAIALVVMII--YLFLrnvpaTIIPAVAVPLSLVGTFAVMVFLDFSinnLTL-----MALTIatGFVVDDAIVVIENI 419
Cdd:PRK14726   379 LIAAILVAALMIgfYGFL-----GVIAVIALIVNVVLIIAVLSLLGAT---LTLpgiagIVLTI--GMAVDSNVLIYERI 448
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084886474  420 sRYIEKGEKPLAAALkgagEIGF-----TIISLTFSLIAVLIPLLFMGDivgRLFREFAVTLAVAILISAVVSLTLTPMM 494
Cdd:PRK14726   449 -REEEKTGHSLIQAL----DRGFsralaTIVDANVTILIAAVILFFLGS---GAVRGFAVTLAVGILTTVFTAFTLTRSL 520

                   ....*..
gi 2084886474  495 CARMLSH 501
Cdd:PRK14726   521 VAVWLRR 527
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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