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Conserved domains on  [gi|2083594412|ref|WP_221028321|]
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iron ABC transporter permease [Klebsiella sp. CVUAS 10975.2]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 44-347 1.51e-77

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 240.36  E-value: 1.51e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  44 GLTRGSFPMPSGTLFRALLGaENVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLG-PDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 124 VLALVLFFPAVGLIWRPLAGM---LGGVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWL 200
Cdd:COG0609    80 AVLAIVLGGGLSALGLPLAAFlgaLLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 201 AGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGL 280
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2083594412 281 MAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 44-347 1.51e-77

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 240.36  E-value: 1.51e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  44 GLTRGSFPMPSGTLFRALLGaENVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLG-PDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 124 VLALVLFFPAVGLIWRPLAGM---LGGVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWL 200
Cdd:COG0609    80 AVLAIVLGGGLSALGLPLAAFlgaLLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 201 AGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGL 280
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2083594412 281 MAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 43-345 3.41e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 203.53  E-value: 3.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  43 FGLTRGSFPMPSGTLFRALLGAENVAEQprFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASI 122
Cdd:pfam01032   8 LSLFIGAVKISPSDVFSALLGGDDSLAA--LIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 123 VVLALVLFFPAVGLIWRPLAGMLGGVLVAL---LVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIW 199
Cdd:pfam01032  86 GAVLAILLGGSLSLFALPLAAFIGALLAALlvyFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 200 LAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVG 279
Cdd:pfam01032 166 LMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVG 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2083594412 280 LMAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWR 345
Cdd:pfam01032 246 LIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
75-347 6.22e-50

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 176.95  E-value: 6.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  75 LFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWRPLAGMLGGVLVALLV 154
Cdd:PRK10577  393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALI 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 155 LALAR--DCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAMIWLAGSLHAATWPLLAVAFCWALPGAMILFLTARA 232
Cdd:PRK10577  473 LLLARrgGFAPERLLLTGIALSALFTALIQLLLASGDPR-AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRW 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 233 ADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLCGSALIGALLVLAT 312
Cdd:PRK10577  552 LDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLA 631

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2083594412 313 DTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:PRK10577  632 DWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-343 4.35e-35

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 128.83  E-value: 4.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  83 LLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWRPLAGMLGGVLVALLVLALARDCS 162
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 163 RPRFILIGIGVSWTLAAAVG-IFMTTADVRDVQTAMIWLAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDR 241
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGvILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 242 TAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLaFA 321
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT-LL 239

                         250       260
                  ....*....|....*....|..
gi 2083594412 322 PLQIPAGIVIALVGCPFFIVLL 343
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 44-347 1.51e-77

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 240.36  E-value: 1.51e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  44 GLTRGSFPMPSGTLFRALLGaENVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLG-PDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 124 VLALVLFFPAVGLIWRPLAGM---LGGVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWL 200
Cdd:COG0609    80 AVLAIVLGGGLSALGLPLAAFlgaLLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 201 AGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGL 280
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2083594412 281 MAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 12-347 1.89e-64

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 207.67  E-value: 1.89e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  12 PLACGGRHFLLRPAALKIAAGMLLVILLLALFGLTRGSFPMPSGTLFRALLGAENVAEqpRFILFDIRLPRLLMALLCGA 91
Cdd:COG4779     8 VLRVGRVSLRLRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGA--SFVVLELRLPRALAALLVGA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  92 MLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWRPLAGMLGGVLVALLVLALARDCSRP-RFILIG 170
Cdd:COG4779    86 ALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGyRLILVG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 171 IGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRL 250
Cdd:COG4779   166 IGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 251 QQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLcGSALIGALLVLATDTIGRLAFAPLQIPAGIV 330
Cdd:COG4779   246 ERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLL-PSALVGALLLLAADLVAQHLLAPVQLPVGVV 324

                         330
                  ....*....|....*..
gi 2083594412 331 IALVGCPFFIVLLWRRR 347
Cdd:COG4779   325 TGALGGPYLLWLLIREN 341
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 43-345 3.41e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 203.53  E-value: 3.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  43 FGLTRGSFPMPSGTLFRALLGAENVAEQprFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASI 122
Cdd:pfam01032   8 LSLFIGAVKISPSDVFSALLGGDDSLAA--LIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 123 VVLALVLFFPAVGLIWRPLAGMLGGVLVAL---LVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIW 199
Cdd:pfam01032  86 GAVLAILLGGSLSLFALPLAAFIGALLAALlvyFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 200 LAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVG 279
Cdd:pfam01032 166 LMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVG 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2083594412 280 LMAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWR 345
Cdd:pfam01032 246 LIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
75-347 6.22e-50

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 176.95  E-value: 6.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  75 LFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWRPLAGMLGGVLVALLV 154
Cdd:PRK10577  393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALI 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 155 LALAR--DCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAMIWLAGSLHAATWPLLAVAFCWALPGAMILFLTARA 232
Cdd:PRK10577  473 LLLARrgGFAPERLLLTGIALSALFTALIQLLLASGDPR-AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRW 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 233 ADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLCGSALIGALLVLAT 312
Cdd:PRK10577  552 LDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLA 631

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2083594412 313 DTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:PRK10577  632 DWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
48-347 1.12e-44

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 155.59  E-value: 1.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  48 GSFPMPsgtlFRALLGAENVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLAL 127
Cdd:PRK09777   24 GVIPLP----WRALLTDWQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 128 VLFFPAVGLIWRPLAGMLGGVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVrDVQTAMIWLAGSLHAA 207
Cdd:PRK09777  100 LLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTHQPMKLALTGVALSALWASLTDYLMLSRPQ-DINNALLWLTGSLWGR 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 208 TWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMAR 287
Cdd:PRK09777  179 DWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMR 258

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 288 FLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:PRK09777  259 SLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
btuC PRK09535
cobalamin ABC transporter permease BtuC;
48-346 2.42e-41

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 147.97  E-value: 2.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  48 GSFPMPSGTLFRALLGAENVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLAL 127
Cdd:PRK09535   64 VGLSLPAPDLEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAA 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 128 VLFFPAVGLIWRPLAGMLGGVLVALLVLALARDCSRPRFILIGIGVS-WTLAAAVGIFMTTADVRDVQTAMIWLAGSLHA 206
Cdd:PRK09535  144 IVLPLAVPFGLQAAAFAGALVAAFGVYAIATENGRTPVATLLLAGVAvQTFLGAVISYLLLHSGESLRRAVYWLMGHLHG 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 207 ATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMA 286
Cdd:PRK09535  224 STWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVM 303

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 287 RFLLRGGQVALLCGSALIGALLVLATDTIGRLafAPLQIPAGIVIALVGCPFFIVLLWRR 346
Cdd:PRK09535  304 RLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRTR 361
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
45-349 1.05e-37

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 142.67  E-value: 1.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  45 LTRGSFPMPSGTLFRALLGAeNVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVV 124
Cdd:PRK10577   29 LTQLSAALPLSQWLQALWGP-DADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLAL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 125 LALVLFFPAVGLIWRPLAGML--GGVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAMIWLAG 202
Cdd:PRK10577  108 VLATLFAPALLALASQLAAFAggLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQY-LQGLFLWGAG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 203 SLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMA 282
Cdd:PRK10577  187 SLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAA 266

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2083594412 283 PHMARFLLRGGQVALLCGSALIGALLVLATDTIGRL--AFAPLQIPAGIVIALVGCPFFIVLLWRRRDA 349
Cdd:PRK10577  267 PNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLlaGVGGELLPTGAVTALIGAPLLLWLLPRLRSA 335
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 69-349 1.69e-35

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 131.51  E-value: 1.69e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  69 EQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWRPLAGMLG-- 146
Cdd:COG4139    45 EAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLAAIAga 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 147 GVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLHAATWPLLAVAFCwALPGAMIL 226
Cdd:COG4139   125 LLVTLLLLAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLA-LLPVLLWL 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 227 FLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLCGSALIGA 306
Cdd:COG4139   204 CLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGA 283

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2083594412 307 LLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRRDA 349
Cdd:COG4139   284 ALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLRRRKI 326
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
49-347 2.99e-35

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 130.97  E-value: 2.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  49 SFPMPSGTLFRALLGAeNVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASivvLALV 128
Cdd:PRK11228   22 AIPISAADALNALLPG-HTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAA---LAMA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 129 LffpAVGLIWRPLAGMLGG-----------VLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAM 197
Cdd:PRK11228   98 L---TSALSPTPFAGYSLAfiaacggglswLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDH-AYGIF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 198 IWLAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGF 277
Cdd:PRK11228  174 YWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAF 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 278 VGLMAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:PRK11228  254 IGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRRG 323
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-343 4.35e-35

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 128.83  E-value: 4.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  83 LLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWRPLAGMLGGVLVALLVLALARDCS 162
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 163 RPRFILIGIGVSWTLAAAVG-IFMTTADVRDVQTAMIWLAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDR 241
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGvILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 242 TAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLaFA 321
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT-LL 239

                         250       260
                  ....*....|....*....|..
gi 2083594412 322 PLQIPAGIVIALVGCPFFIVLL 343
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYLL 261
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 69-349 8.67e-31

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 118.90  E-value: 8.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  69 EQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLIWR-PLAGMLGG 147
Cdd:PRK03784   48 PRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWAlSLCAIAGA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 148 VLVALLVLALAR--DCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLHAATWPLLAVAfcWALPGAMI 225
Cdd:PRK03784  128 LLITLILLRFARrhRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLM--LALLPVLI 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 226 -LFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLCGSALI 304
Cdd:PRK03784  206 wLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALA 285

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2083594412 305 GALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRRDA 349
Cdd:PRK03784  286 GASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSHRA 330
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
45-347 2.78e-30

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 117.89  E-value: 2.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  45 LTRGSFPMPSGTLFRALLGAENVAEQprFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVV 124
Cdd:PRK10441   28 LLIGAKSLPASVVLEALSGTCQSADC--TIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 125 LALVLFFPAV---GLIWRPLAG-MLGGVLVALLVLALARDCSRPRFILIGIGVSWTL-AAAVGIFMTTADVRDvqTAMIW 199
Cdd:PRK10441  106 VLGAALFGYSsaqEQLAMAFAGaLVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLeGLTSGIALLNPDVYD--QLRFW 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 200 LAGSLHAATWPLLAVAFCWALPGAMILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVG 279
Cdd:PRK10441  184 QAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIG 263

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2083594412 280 LMAPHMARFLLRGGQVALLCGSALIGALLVLATDTIGRLaFAPLQIPAGIVIALVGCPFFIVLLWRRR 347
Cdd:PRK10441  264 LMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRL-LVPGELRVSVVSAFIGAPVLIFLVRRKT 330
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
43-345 2.91e-29

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 114.81  E-value: 2.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412  43 FGLTRGSFPMPSGTLFRALLGaeNVAEQPRFILFDIRLPRLLMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGA-S 121
Cdd:PRK10440   25 WGLRSGAVTLETSQVFAALMG--DAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAwS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 122 IVVLALVLFFPAVGLIWRPLAGMLGGVLVALLVLALARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLA 201
Cdd:PRK10440  103 GVLVAMVLFGQDLTAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2083594412 202 GSLHAATWP--LLAVAFC-WALPGAMILFLTARAADaalLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFV 278
Cdd:PRK10440  183 GSLNGLTWAktSPSAPIIiLMLIAAALLVRRMRLLE---MGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFI 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2083594412 279 GLMAPHMARFLLRGGQVALLcGSALIGALLVLATDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWR 345
Cdd:PRK10440  260 ALVAPHIARRLSGTARWGLT-QAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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