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Conserved domains on  [gi|2055730135|ref|WP_216609095|]
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FHA domain-containing protein [Myxococcus xanthus]

Protein Classification

FHA domain-containing protein( domain architecture ID 11507892)

FHA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 168-254 9.00e-15

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


:

Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 69.23  E-value: 9.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFV---TVGGTEALTPRTH 244
Cdd:cd00060     2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVngkRITPPVPLQDGDV 81

                          90
                  ....*....|
gi 2055730135 245 FSAGQRLFRF 254
Cdd:cd00060    82 IRLGDTTFRF 91
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
290-374 5.04e-12

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


:

Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 61.51  E-value: 5.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 290 GGRAGRAVMTAAPLLTIG-LAHCDLSFPgDEGLAGRHCELSPTPTGALLRDLSGGLGTYV---RLASgvERPLRPGDRVR 365
Cdd:COG1716     9 GPLAGRRFPLDGGPLTIGrAPDNDIVLD-DPTVSRRHARIRRDGGGWVLEDLGSTNGTFVngqRVTE--PAPLRDGDVIR 85


                  ....*....
gi 2055730135 366 LGQHVLQVE 374
Cdd:COG1716    86 LGKTELRFR 94
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
51-150 1.55e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  51 AVARPG-TPPGSRPVAVSNFPGG-KVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAP-PGIMARTGG 127
Cdd:PRK14951  380 TPARPEaAAPAAAPVAQAAAAPApAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPaPPAQAAPET 459

                          90       100
                  ....*....|....*....|...
gi 2055730135 128 ASGPATTRPPPPVPDSAMPSRAG 150
Cdd:PRK14951  460 VAIPVRVAPEPAVASAAPAPAAA 482
 
Name Accession Description Interval E-value
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 168-254 9.00e-15

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 69.23  E-value: 9.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFV---TVGGTEALTPRTH 244
Cdd:cd00060     2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVngkRITPPVPLQDGDV 81

                          90
                  ....*....|
gi 2055730135 245 FSAGQRLFRF 254
Cdd:cd00060    82 IRLGDTTFRF 91
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
290-374 5.04e-12

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 61.51  E-value: 5.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 290 GGRAGRAVMTAAPLLTIG-LAHCDLSFPgDEGLAGRHCELSPTPTGALLRDLSGGLGTYV---RLASgvERPLRPGDRVR 365
Cdd:COG1716     9 GPLAGRRFPLDGGPLTIGrAPDNDIVLD-DPTVSRRHARIRRDGGGWVLEDLGSTNGTFVngqRVTE--PAPLRDGDVIR 85


                  ....*....
gi 2055730135 366 LGQHVLQVE 374
Cdd:COG1716    86 LGKTELRFR 94
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
168-254 8.32e-12

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 61.13  E-value: 8.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT---VGGTEALTPRTH 244
Cdd:COG1716     4 LVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNgqrVTEPAPLRDGDV 83

                          90
                  ....*....|
gi 2055730135 245 FSAGQRLFRF 254
Cdd:COG1716    84 IRLGKTELRF 93
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 288-374 1.95e-10

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 56.90  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 288 LVGGRAGRAVMTAAPLLTIG-LAHCDLSFPgDEGLAGRHCELSPTPTGALLRDLSGGLGTYV---RLASgvERPLRPGDR 363
Cdd:cd00060     5 LDGDGGGREFPLTKGVVTIGrSPDCDIVLD-DPSVSRRHARIEVDGGGVYLEDLGSTNGTFVngkRITP--PVPLQDGDV 81

                          90
                  ....*....|.
gi 2055730135 364 VRLGQHVLQVE 374
Cdd:cd00060    82 IRLGDTTFRFE 92
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 304-374 2.66e-06

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 48.91  E-value: 2.66e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2055730135 304 LTIG-LAHCDLSFPGDEG-LAGRHCELSPTPTGALLRDLSGGlGTYV-----RLASGVERPLRPGDRVRLGQHVLQVE 374
Cdd:TIGR03354  26 GTIGrSEDCDWVLPDPERhVSGRHARIRYRDGAYLLTDLSTN-GVFLngsgsPLGRGNPVRLEQGDRLRLGDYEIRVS 102
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 272-373 1.04e-04

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 40.71  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 272 GAPVPLGQAVYGVeemlvgGRAGRavmtaaplltiglahCDLSFpGDEGLAGRHCELSPTPTGALLRDLSGGLGTYV--R 349
Cdd:pfam16697   9 GAEFPLEGGRYRI------GSDPD---------------CDIVL-SDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVngQ 66

                          90       100
                  ....*....|....*....|....
gi 2055730135 350 LASGVERPLRPGDRVRLGQHVLQV 373
Cdd:pfam16697  67 RVTELGIALRPGDRIELGQTEFCL 90
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 51-150 1.55e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  51 AVARPG-TPPGSRPVAVSNFPGG-KVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAP-PGIMARTGG 127
Cdd:PRK14951  380 TPARPEaAAPAAAPVAQAAAAPApAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPaPPAQAAPET 459

                          90       100
                  ....*....|....*....|...
gi 2055730135 128 ASGPATTRPPPPVPDSAMPSRAG 150
Cdd:PRK14951  460 VAIPVRVAPEPAVASAAPAPAAA 482
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 170-254 1.59e-04

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 40.32  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 170 VIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT-VGGTE---ALTPRTHF 245
Cdd:pfam16697   2 VLSGPHAGAEFPLEGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVNgQRVTElgiALRPGDRI 81


                  ....*....
gi 2055730135 246 SAGQRLFRF 254
Cdd:pfam16697  82 ELGQTEFCL 90
 
Name Accession Description Interval E-value
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 168-254 9.00e-15

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 69.23  E-value: 9.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFV---TVGGTEALTPRTH 244
Cdd:cd00060     2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVngkRITPPVPLQDGDV 81

                          90
                  ....*....|
gi 2055730135 245 FSAGQRLFRF 254
Cdd:cd00060    82 IRLGDTTFRF 91
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
290-374 5.04e-12

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 61.51  E-value: 5.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 290 GGRAGRAVMTAAPLLTIG-LAHCDLSFPgDEGLAGRHCELSPTPTGALLRDLSGGLGTYV---RLASgvERPLRPGDRVR 365
Cdd:COG1716     9 GPLAGRRFPLDGGPLTIGrAPDNDIVLD-DPTVSRRHARIRRDGGGWVLEDLGSTNGTFVngqRVTE--PAPLRDGDVIR 85


                  ....*....
gi 2055730135 366 LGQHVLQVE 374
Cdd:COG1716    86 LGKTELRFR 94
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
168-254 8.32e-12

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 61.13  E-value: 8.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT---VGGTEALTPRTH 244
Cdd:COG1716     4 LVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNgqrVTEPAPLRDGDV 83

                          90
                  ....*....|
gi 2055730135 245 FSAGQRLFRF 254
Cdd:COG1716    84 IRLGKTELRF 93
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 288-374 1.95e-10

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 56.90  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 288 LVGGRAGRAVMTAAPLLTIG-LAHCDLSFPgDEGLAGRHCELSPTPTGALLRDLSGGLGTYV---RLASgvERPLRPGDR 363
Cdd:cd00060     5 LDGDGGGREFPLTKGVVTIGrSPDCDIVLD-DPSVSRRHARIEVDGGGVYLEDLGSTNGTFVngkRITP--PVPLQDGDV 81

                          90
                  ....*....|.
gi 2055730135 364 VRLGQHVLQVE 374
Cdd:cd00060    82 IRLGDTTFRFE 92
COG3456 COG3456
Predicted component of the type VI protein secretion system, contains a FHA domain [Signal ...
 288-374 4.74e-08

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442679 [Multi-domain]  Cd Length: 402  Bit Score: 54.38  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 288 LVGGRAGRAVMTAAPLlTIGL-AHCDLSFPGDEG-LAGRHCELSPTPTGALLRDLSGGlGTYV-----RLASGVERPLRP 360
Cdd:COG3456    13 LESGSAASATFGRGGG-TIGRsADCDWVLPDPDRsVSRRHAEIRFRDGAFCLTDLSTN-GTFLngsdhPLGPGRPVRLRD 90

                          90
                  ....*....|....
gi 2055730135 361 GDRVRLGQHVLQVE 374
Cdd:COG3456    91 GDRLRIGDYEIRVE 104
FHA_FhaB-like cd22693
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 168-253 2.04e-06

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438745 [Multi-domain]  Cd Length: 91  Bit Score: 45.37  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT---VGGTEALTPRTH 244
Cdd:cd22693     1 LVIIEGTLQGQTFPIDKSGITIGRADDNDLVLSDDFVSSRHARIYLQGSSWYLEDLGSTNGTFVNgnrVTQPVVVQPGDT 80


                  ....*....
gi 2055730135 245 FSAGQRLFR 253
Cdd:cd22693    81 IRIGATVFE 89
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 304-374 2.66e-06

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 48.91  E-value: 2.66e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2055730135 304 LTIG-LAHCDLSFPGDEG-LAGRHCELSPTPTGALLRDLSGGlGTYV-----RLASGVERPLRPGDRVRLGQHVLQVE 374
Cdd:TIGR03354  26 GTIGrSEDCDWVLPDPERhVSGRHARIRYRDGAYLLTDLSTN-GVFLngsgsPLGRGNPVRLEQGDRLRLGDYEIRVS 102
FHA_CHFR cd22672
forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains ...
 305-366 4.68e-05

forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains protein (CHFR); CHFR, also called RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22 and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated-(FHA) domain and a RING-HC finger. The CHFR FHA domain has been crystallized as a segment-swapped dimer. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438724 [Multi-domain]  Cd Length: 108  Bit Score: 42.28  E-value: 4.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2055730135 305 TIGLA-HCDLSFPGDEGLAGRHCELSPTPTGAL-LRDLSGGlGTYV---RLASGVERPLRPGDRVRL 366
Cdd:cd22672    24 TIGRAkDCDLSFPGNKLVSGDHCKIIRDEKGQVwLEDTSTN-GTLVnkvKVVKGQKVELKHGDVIYL 89
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
 188-232 9.10e-05

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 41.16  E-value: 9.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2055730135 188 VVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT 232
Cdd:cd22667    23 TVGRKDCDIIIVDDSSISRKHATLTVLHPEANLSDPDTRPELTLK 67
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 272-373 1.04e-04

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 40.71  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 272 GAPVPLGQAVYGVeemlvgGRAGRavmtaaplltiglahCDLSFpGDEGLAGRHCELSPTPTGALLRDLSGGLGTYV--R 349
Cdd:pfam16697   9 GAEFPLEGGRYRI------GSDPD---------------CDIVL-SDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVngQ 66

                          90       100
                  ....*....|....*....|....
gi 2055730135 350 LASGVERPLRPGDRVRLGQHVLQV 373
Cdd:pfam16697  67 RVTELGIALRPGDRIELGQTEFCL 90
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
 299-369 1.23e-04

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 40.77  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 299 TAAPLLTIGLAHCDLSFPGDEGLAGRHCEL-----------SPTPTGALLRDLSGgLGTYV---RLASGVERPLRPGDRV 364
Cdd:cd22667    17 LPGGEYTVGRKDCDIIIVDDSSISRKHATLtvlhpeanlsdPDTRPELTLKDLSK-YGTFVngeKLKGGSEVTLKDGDVI 95


                  ....*
gi 2055730135 365 RLGQH 369
Cdd:cd22667    96 TFGVL 100
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 51-150 1.55e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  51 AVARPG-TPPGSRPVAVSNFPGG-KVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAP-PGIMARTGG 127
Cdd:PRK14951  380 TPARPEaAAPAAAPVAQAAAAPApAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPaPPAQAAPET 459

                          90       100
                  ....*....|....*....|...
gi 2055730135 128 ASGPATTRPPPPVPDSAMPSRAG 150
Cdd:PRK14951  460 VAIPVRVAPEPAVASAAPAPAAA 482
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 170-254 1.59e-04

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 40.32  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135 170 VIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT-VGGTE---ALTPRTHF 245
Cdd:pfam16697   2 VLSGPHAGAEFPLEGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVNgQRVTElgiALRPGDRI 81


                  ....*....
gi 2055730135 246 SAGQRLFRF 254
Cdd:pfam16697  82 ELGQTEFCL 90
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 80-147 2.69e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 2.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2055730135  80 PPAPSAIPPGLRPSarTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGASGPATTRPPPPVPDSAMPS 147
Cdd:PRK14950  373 AAAPSPVRPTPAPS--TRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPV 438
FHA_GarA_OdhI-like cd22684
forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium ...
 168-231 3.80e-04

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438736 [Multi-domain]  Cd Length: 94  Bit Score: 39.29  E-value: 3.80e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2055730135 168 LAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFV 231
Cdd:cd22684     4 LVVRRGPNAGARFLLDQDVTTAGRHPESDIFLDDVTVSRRHAEFRRAEGGFVVRDVGSLNGTYV 67
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
57-149 4.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  57 TPPGSRPVAVSNFPGGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGASGPATTRP 136
Cdd:PRK12323  386 APAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPA 465

                          90
                  ....*....|....*...
gi 2055730135 137 -----PPPVPDSAMPSRA 149
Cdd:PRK12323  466 aagprPVAAAAAAAPARA 483
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 187-231 4.27e-04

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 38.33  E-value: 4.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2055730135 187 CVVGRQRGAILFADDAFVSPLHATFLVKDG-ALYVRDESSASGVFV 231
Cdd:pfam00498   1 VTIGRSPDCDIVLDDPSVSRRHAEIRYDGGgRFYLEDLGSTNGTFV 46
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
 177-252 4.68e-04

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 38.86  E-value: 4.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2055730135 177 GQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFvtVGGTEALTPRTHFSAGQRLF 252
Cdd:cd22680    13 GKKFPFDFSSVSIGRDPENVIVIPDPFVSRNHARITVDSNEIYIEDLGSTNGTF--VNDFKRIKGPAKLHPNDIIK 86
PHA03247 PHA03247
large tegument protein UL36; Provisional
 55-183 5.51e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 5.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135   55 PGTPPGSRPVAVSNFPGGKVAEPVVPPAPS--AIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPgimartggasgpa 132
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTEsfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP------------- 2933

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2055730135  133 ttrPPPPVPDSAMPSRAGAATTAPRPAPPAASRFGlAVIAGSTRGQRYKLP 183
Cdd:PHA03247  2934 ---PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVP 2980
FHA_ZEP-like cd22702
forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar ...
 186-232 6.66e-04

forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar proteins; ZEP, also called protein ABA DEFICIENT 1, ABA1, protein IMPAIRED IN BABA-INDUCED STERILITY 3, protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6, or protein NON-PHOTOCHEMICAL QUENCHING 2, plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. It converts zeaxanthin into antheraxanthin and subsequently violaxanthin. ZEP is required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression, and disease resistance and non-photochemical quencing (NPQ). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438754 [Multi-domain]  Cd Length: 123  Bit Score: 39.33  E-value: 6.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2055730135 186 GCVVGR-----QRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVT 232
Cdd:cd22702    33 PCIIGSdphqaISGISVVIPSPQVSELHARITCKNGAFFLTDLGSEHGTWIN 84
PHA03378 PHA03378
EBNA-3B; Provisional
 55-145 7.26e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 7.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  55 PGTPPGSRPVAVSNFPGGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAgltverPPQQRTPTAPPGIMARTGGASGPATT 134
Cdd:PHA03378  703 PMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAA------PGRARPPAAAPGRARPPAAAPGAPTP 776

                          90
                  ....*....|.
gi 2055730135 135 RPPPPVPDSAM 145
Cdd:PHA03378  777 QPPPQAPPAPQ 787
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 53-150 8.58e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 8.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  53 ARPGTPPGSRPVAVSNFPGGKVAEPVVPPAPSAiPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGASGPA 132
Cdd:PRK07764  628 APAGAAAAPAEASAAPAPGVAAPEHHPKHVAVP-DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPA 706

                          90
                  ....*....|....*...
gi 2055730135 133 TTRPPPPVPDSAMPSRAG 150
Cdd:PRK07764  707 ATPPAGQADDPAAQPPQA 724
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 70-149 8.85e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 8.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  70 PGGKVAEPVVPPAPSAIPPGLRPSARTPPP--TAAGLTVERPPQQRTPTAPPGIMARTGGASGPATTRPPPPVPDSAMPS 147
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAqaAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV 445


                  ..
gi 2055730135 148 RA 149
Cdd:PRK14951  446 AL 447
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 51-149 1.43e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  51 AVARPGTPPGSRPVAVSNFPGGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGASG 130
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAA 473

                          90
                  ....*....|....*....
gi 2055730135 131 PATTRPPPPVPDSAMPSRA 149
Cdd:PRK07764  474 PEPTAAPAPAPPAAPAPAA 492
PHA03247 PHA03247
large tegument protein UL36; Provisional
 53-149 1.89e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135   53 ARPGTPPGSRPVAVSNFPGGKVAepvvpPAPSAIPPGlRPSARTPPPTAAGLTVERP--PQQRTPTAPP----GIMARTG 126
Cdd:PHA03247  2746 AGPATPGGPARPARPPTTAGPPA-----PAPPAAPAA-GPPRRLTRPAVASLSESREslPSPWDPADPPaavlAPAAALP 2819

                           90       100
                   ....*....|....*....|...
gi 2055730135  127 GASGPATTRPPPPVPDSAMPSRA 149
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPP 2842
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 60-131 2.65e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.93  E-value: 2.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2055730135  60 GSRPVAVSNFPGGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERP-PQQRTPTAPPGIMARTGGASGP 131
Cdd:PRK14954  379 GVAPSPAGSPDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPtPEQQPPVARSAPLPPSPQASAP 451
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 79-147 3.25e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.22  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2055730135  79 VPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMA--RTGGASGPATTRPPPPVPDSAMPS 147
Cdd:PHA03264  266 PPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPagRDGAAGGEPKPGPPRPAPDADRPE 336
PHA03247 PHA03247
large tegument protein UL36; Provisional
 51-147 3.26e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135   51 AVARPGTPPGSRPVAVSNFPGGKVAEPVVPPAP--SAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGA 128
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrdDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                           90
                   ....*....|....*....
gi 2055730135  129 SGPATTRPPPPVPDSAMPS 147
Cdd:PHA03247  2700 DPPPPPPTPEPAPHALVSA 2718
FHA_Rv1747-like_rpt1 cd22694
first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 168-231 4.31e-03

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438746 [Multi-domain]  Cd Length: 93  Bit Score: 36.15  E-value: 4.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2055730135 168 LAVIAGSTRGQRykLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFV 231
Cdd:cd22694     1 LTIRIPGGELRF--DPGSSVRIGRDPDADVRLDDPRVSRRHALLEFDGDGWVYTDLGSRNGTYL 62
PHA03247 PHA03247
large tegument protein UL36; Provisional
 50-148 5.10e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135   50 LAVARPGTPPGSRPVAVSnfpggkvaePVVPPAPSAIPPGLRPSARTPPPTAAGLTVerPPQQRTPTAPPGIMARTGGAS 129
Cdd:PHA03247  2791 LSESRESLPSPWDPADPP---------AAVLAPAAALPPAASPAGPLPPPTSAQPTA--PPPPPGPPPPSLPLGGSVAPG 2859

                           90       100
                   ....*....|....*....|.
gi 2055730135  130 GPATTRPPP--PVPDSAMPSR 148
Cdd:PHA03247  2860 GDVRRRPPSrsPAAKPAAPAR 2880
PHA03247 PHA03247
large tegument protein UL36; Provisional
 55-149 5.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 5.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135   55 PGTPPGSRPVAVSNfpggKVAEPVVPPAPSAIPPGLrPSARTPPPTAAG----LTVERPPQQRTPTAPPGIMARTGGASG 130
Cdd:PHA03247  2704 PPPTPEPAPHALVS----ATPLPPGPAAARQASPAL-PAAPAPPAVPAGpatpGGPARPARPPTTAGPPAPAPPAAPAAG 2778

                           90
                   ....*....|....*....
gi 2055730135  131 PATTRPPPPVPdSAMPSRA 149
Cdd:PHA03247  2779 PPRRLTRPAVA-SLSESRE 2796
motB PRK12799
flagellar motor protein MotB; Reviewed
 53-146 7.04e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 38.16  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  53 ARPGTP-PGSRPVAVSnfpgGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGASGP 131
Cdd:PRK12799  319 SSAAIPsPAVIPSSVT----TQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVNMQPQPMSTTETQQSSTGNITS 394

                          90
                  ....*....|....*...
gi 2055730135 132 ATTRPP---PPVPDSAMP 146
Cdd:PRK12799  395 TANGPTtslPAAPASNIP 412
FHA_FHAD1 cd22700
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 ...
 305-368 8.33e-03

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438752 [Multi-domain]  Cd Length: 96  Bit Score: 35.31  E-value: 8.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2055730135 305 TIGLAHCDLSFpGDEGLAGRHC--ELSPTPTGALLRDLSGGLGTYV---RLASGVERpLRPGDRVRLGQ 368
Cdd:cd22700    19 TIGREGCDLVL-QSPGVEEQHAviEYSEQENCFVLQDLNTAQGTYVndcRIQNAAVR-LAPGDVLRFGF 85
PHA03378 PHA03378
EBNA-3B; Provisional
 51-145 9.69e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 38.12  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2055730135  51 AVARPGTPPGSRPVAVSNFPGGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAGltvERPPQQRTPTAPPGIMARTGGASG 130
Cdd:PHA03378  719 AATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP---GAPTPQPPPQAPPAPQQRPRGAPT 795

                          90
                  ....*....|....*
gi 2055730135 131 PattRPPPPVPDSAM 145
Cdd:PHA03378  796 P---QPPPQAGPTSM 807
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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