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Conserved domains on  [gi|2051267521|ref|WP_215807820|]
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FAD-dependent oxidoreductase [Aeromonas jandaei]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11496619)

FAD-dependent oxidoreductase may function as an aminophosphonate oxidoreductase that is associated with the import and catabolism of 2-aminoethylphosphonate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phn_aa_oxid TIGR03329
putative aminophosphonate oxidoreductase; This clade of sequences are members of the pfam01266 ...
 5-468 0e+00

putative aminophosphonate oxidoreductase; This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.


:

Pssm-ID: 274522 [Multi-domain]  Cd Length: 460  Bit Score: 855.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521   5 PFWLAEALAAEQPAPPTPLHGHHEADVCIVGGGFTGLWSAIALKQAEPHLRVMVLEKDRCGSGASGRNGGCLLTWSAKYL 84
Cdd:TIGR03329   1 PFWLEQALALEQPDPAPPLVGDTQADVCIVGGGFTGLWTAIMIKQQRPALDVLVLEADLCGAGASGRNGGCMLTWSTKFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  85 TLKRLFGEEQAAWLVQRSEQAVHEIARFCETHNIEAELRVEGTCYTATSEAQRGLMEPVLRELQRADLNQWQAIEEGELA 164
Cdd:TIGR03329  81 TLKRLFGEAEAARLVKASEQAVLEIAAFCEQHNIDAQLRLDGTLYTATNPAQVGSMDPVVDALERRGINSWQRLSEGELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 165 SQSGSHVHLEGLYSPHAGSVQPALLVRGLLRVARELGVEVYEHSPMQRLEAGQPARVQTPQGEVRASKVVLALNSAMVQH 244
Cdd:TIGR03329 161 RRTGSARHLEGFYSPVAASVQPGLLVRGLRRVALELGVEIHENTPMTGLEEGQPAVVRTPDGQVTADKVVLALNAWMASH 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 245 FREFRRSIVLVSSDMVITDPAPDALAAQQLAHGRSVVDGRTFVHYYRSTPQGRLMLGKGGNTFAFANRHLAEFDAPSRYL 324
Cdd:TIGR03329 241 FPQFERSIAIVSSDMVITEPAPDLLAATGLDHGTSVLDSRIFVHYYRSTPDGRLMLGKGGNTFAYGGRMLPVFNQPSPYE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 325 APLTRTLRRFFPALKEVPIAASWCGASDRSVDGLPFFGHWRGQPNIVYGLGYSGNGVAQSWIGGQILAALvrdeVREEDK 404
Cdd:TIGR03329 321 ALLTRSLRKFFPALAEVPIAASWNGPSDRSVTGLPFFGRLNGQPNVFYGFGYSGNGVAPSRMGGQILSSL----VLGLDN 396

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051267521 405 PWRDCALVSGPRGYFPPEPFRWLGAMAVRNAIRRKERAEDENRPVAWYDKQLAKLADAAGKADK 468
Cdd:TIGR03329 397 PWTRSPLVKGPLGYFPPEPIRYLGALVVRNAIRRKERAEDEGRRPFLLDKWLAKFAAAAGKADK 460
 
Name Accession Description Interval E-value
Phn_aa_oxid TIGR03329
putative aminophosphonate oxidoreductase; This clade of sequences are members of the pfam01266 ...
 5-468 0e+00

putative aminophosphonate oxidoreductase; This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.


Pssm-ID: 274522 [Multi-domain]  Cd Length: 460  Bit Score: 855.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521   5 PFWLAEALAAEQPAPPTPLHGHHEADVCIVGGGFTGLWSAIALKQAEPHLRVMVLEKDRCGSGASGRNGGCLLTWSAKYL 84
Cdd:TIGR03329   1 PFWLEQALALEQPDPAPPLVGDTQADVCIVGGGFTGLWTAIMIKQQRPALDVLVLEADLCGAGASGRNGGCMLTWSTKFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  85 TLKRLFGEEQAAWLVQRSEQAVHEIARFCETHNIEAELRVEGTCYTATSEAQRGLMEPVLRELQRADLNQWQAIEEGELA 164
Cdd:TIGR03329  81 TLKRLFGEAEAARLVKASEQAVLEIAAFCEQHNIDAQLRLDGTLYTATNPAQVGSMDPVVDALERRGINSWQRLSEGELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 165 SQSGSHVHLEGLYSPHAGSVQPALLVRGLLRVARELGVEVYEHSPMQRLEAGQPARVQTPQGEVRASKVVLALNSAMVQH 244
Cdd:TIGR03329 161 RRTGSARHLEGFYSPVAASVQPGLLVRGLRRVALELGVEIHENTPMTGLEEGQPAVVRTPDGQVTADKVVLALNAWMASH 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 245 FREFRRSIVLVSSDMVITDPAPDALAAQQLAHGRSVVDGRTFVHYYRSTPQGRLMLGKGGNTFAFANRHLAEFDAPSRYL 324
Cdd:TIGR03329 241 FPQFERSIAIVSSDMVITEPAPDLLAATGLDHGTSVLDSRIFVHYYRSTPDGRLMLGKGGNTFAYGGRMLPVFNQPSPYE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 325 APLTRTLRRFFPALKEVPIAASWCGASDRSVDGLPFFGHWRGQPNIVYGLGYSGNGVAQSWIGGQILAALvrdeVREEDK 404
Cdd:TIGR03329 321 ALLTRSLRKFFPALAEVPIAASWNGPSDRSVTGLPFFGRLNGQPNVFYGFGYSGNGVAPSRMGGQILSSL----VLGLDN 396

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051267521 405 PWRDCALVSGPRGYFPPEPFRWLGAMAVRNAIRRKERAEDENRPVAWYDKQLAKLADAAGKADK 468
Cdd:TIGR03329 397 PWTRSPLVKGPLGYFPPEPIRYLGALVVRNAIRRKERAEDEGRRPFLLDKWLAKFAAAAGKADK 460
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
27-403 1.44e-72

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 233.26  E-value: 1.44e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  27 HEADVCIVGGGFTGLWSAIALKQAepHLRVMVLEKDRCGSGASGRNGGCLLTWsakyltlkrlFGEEQAAWLVQRSEQAV 106
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARR--GLDVTVLERGRPGSGASGRNAGQLRPG----------LAALADRALVRLAREAL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 107 HEIARFCETHNIEAELRVEGTCYTATSEAQRGLMEPVLRELQRADLNqWQAIEEGELASQS---GSHVHLEGLYSPHAGS 183
Cdd:COG0665    69 DLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLP-VELLDAAELREREpglGSPDYAGGLYDPDDGH 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 184 VQPALLVRGLLRVARELGVEVYEHSPMQRLE--AGQPARVQTPQGEVRASKVVLALNSAMVQHFREFRRSIVL--VSSDM 259
Cdd:COG0665   148 VDPAKLVRALARAARAAGVRIREGTPVTGLEreGGRVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLrpVRGYV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 260 VITDPAPDALAAQQLAHGRsvvdgrtfvHYYRSTPQGRLMLGkggntfAFANRHLAEFDAPSRYLAPLTRTLRRFFPALK 339
Cdd:COG0665   228 LVTEPLPDLPLRPVLDDTG---------VYLRPTADGRLLVG------GTAEPAGFDRAPTPERLEALLRRLRRLFPALA 292

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051267521 340 EVPIAASWCGASDRSVDGLPFFGHWRGQPNIVYGLGYSGNGVAQSWIGGQILAALVRDEVREED 403
Cdd:COG0665   293 DAEIVRAWAGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLD 356
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 30-394 1.66e-51

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 177.59  E-value: 1.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  30 DVCIVGGGFTGLWSAIALkqAEPHLRVMVLEKD-RCGSGASGRNGGCLLTWSAKYltlkrlfgeeQAAWLVQRSEQAVHE 108
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYEL--ARRGLSVTLLERGdDPGSGASGRNAGLIHPGLRYL----------EPSELARLALEALDL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 109 IARFCETHNIEAELRVEGTCYTATSEAQRGLMEpvLRELQRADLNQWQAIEEGELAS-QSGSHVHLEGLYSPHAGSVQPA 187
Cdd:pfam01266  69 WEELEEELGIDCGFRRCGVLVLARDEEEEALEK--LLAALRRLGVPAELLDAEELRElEPLLPGLRGGLFYPDGGHVDPA 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 188 LLVRGLLRVARELGVEVYEHSPMQRLEAGQPARVQTPQGEVRAskVVLALNS-AMVQHFREFRRSIVLVSSDMVITDPAP 266
Cdd:pfam01266 147 RLLRALARAAEALGVRIIEGTEVTGIEEEGGVWGVVTTGEADA--VVNAAGAwADLLALPGLRLPVRPVRGQVLVLEPLP 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 267 DALaaqqLAHGRSVVDGRTFVHYYRSTPQGRLMLGKGGNTFAFANrhlaeFDAPSRYLAPLTRTLRRFFPALKEvpIAAS 346
Cdd:pfam01266 225 EAL----LILPVPITVDPGRGVYLRPRADGRLLLGGTDEEDGFDD-----PTPDPEEIEELLEAARRLFPALAD--IERA 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2051267521 347 WCGASDrSVDGLPFFGHwRGQPNIVYGLGYSGNGVAQSWIGGQILAAL 394
Cdd:pfam01266 294 WAGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
30-234 6.11e-13

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 70.24  E-value: 6.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  30 DVCIVGGGFTGLWSAIALKQAEPHLRVMVLEK-DRCGSGASGRNGGCLltWSAKYLT---LKRLFGEEQAAWLVQrseqa 105
Cdd:PRK11728    4 DFVIIGGGIVGLSTAMQLQERYPGARIAVLEKeSGPARHQTGHNSGVI--HAGVYYTpgsLKARFCRRGNEATKA----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 106 vheiarFCETHNIEAElrVEGTCYTATSEAQRGLMEpvlRELQRADLNQWQA--IEEGELASQSGSHVHLEGLYSPHAGS 183
Cdd:PRK11728   77 ------FCDQHGIPYE--ECGKLLVATSELELERME---ALYERARANGIEVerLDAEELREREPNIRGLGAIFVPSTGI 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2051267521 184 VQPALLVRGLLRVARELGVEVYEHSPMQRL-EAGQPARVQTPQGEVRASKVV 234
Cdd:PRK11728  146 VDYRAVAEAMAELIQARGGEIRLGAEVTALdEHANGVVVRTTQGEYEARTLI 197
 
Name Accession Description Interval E-value
Phn_aa_oxid TIGR03329
putative aminophosphonate oxidoreductase; This clade of sequences are members of the pfam01266 ...
 5-468 0e+00

putative aminophosphonate oxidoreductase; This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.


Pssm-ID: 274522 [Multi-domain]  Cd Length: 460  Bit Score: 855.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521   5 PFWLAEALAAEQPAPPTPLHGHHEADVCIVGGGFTGLWSAIALKQAEPHLRVMVLEKDRCGSGASGRNGGCLLTWSAKYL 84
Cdd:TIGR03329   1 PFWLEQALALEQPDPAPPLVGDTQADVCIVGGGFTGLWTAIMIKQQRPALDVLVLEADLCGAGASGRNGGCMLTWSTKFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  85 TLKRLFGEEQAAWLVQRSEQAVHEIARFCETHNIEAELRVEGTCYTATSEAQRGLMEPVLRELQRADLNQWQAIEEGELA 164
Cdd:TIGR03329  81 TLKRLFGEAEAARLVKASEQAVLEIAAFCEQHNIDAQLRLDGTLYTATNPAQVGSMDPVVDALERRGINSWQRLSEGELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 165 SQSGSHVHLEGLYSPHAGSVQPALLVRGLLRVARELGVEVYEHSPMQRLEAGQPARVQTPQGEVRASKVVLALNSAMVQH 244
Cdd:TIGR03329 161 RRTGSARHLEGFYSPVAASVQPGLLVRGLRRVALELGVEIHENTPMTGLEEGQPAVVRTPDGQVTADKVVLALNAWMASH 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 245 FREFRRSIVLVSSDMVITDPAPDALAAQQLAHGRSVVDGRTFVHYYRSTPQGRLMLGKGGNTFAFANRHLAEFDAPSRYL 324
Cdd:TIGR03329 241 FPQFERSIAIVSSDMVITEPAPDLLAATGLDHGTSVLDSRIFVHYYRSTPDGRLMLGKGGNTFAYGGRMLPVFNQPSPYE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 325 APLTRTLRRFFPALKEVPIAASWCGASDRSVDGLPFFGHWRGQPNIVYGLGYSGNGVAQSWIGGQILAALvrdeVREEDK 404
Cdd:TIGR03329 321 ALLTRSLRKFFPALAEVPIAASWNGPSDRSVTGLPFFGRLNGQPNVFYGFGYSGNGVAPSRMGGQILSSL----VLGLDN 396

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051267521 405 PWRDCALVSGPRGYFPPEPFRWLGAMAVRNAIRRKERAEDENRPVAWYDKQLAKLADAAGKADK 468
Cdd:TIGR03329 397 PWTRSPLVKGPLGYFPPEPIRYLGALVVRNAIRRKERAEDEGRRPFLLDKWLAKFAAAAGKADK 460
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
27-403 1.44e-72

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 233.26  E-value: 1.44e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  27 HEADVCIVGGGFTGLWSAIALKQAepHLRVMVLEKDRCGSGASGRNGGCLLTWsakyltlkrlFGEEQAAWLVQRSEQAV 106
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARR--GLDVTVLERGRPGSGASGRNAGQLRPG----------LAALADRALVRLAREAL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 107 HEIARFCETHNIEAELRVEGTCYTATSEAQRGLMEPVLRELQRADLNqWQAIEEGELASQS---GSHVHLEGLYSPHAGS 183
Cdd:COG0665    69 DLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLP-VELLDAAELREREpglGSPDYAGGLYDPDDGH 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 184 VQPALLVRGLLRVARELGVEVYEHSPMQRLE--AGQPARVQTPQGEVRASKVVLALNSAMVQHFREFRRSIVL--VSSDM 259
Cdd:COG0665   148 VDPAKLVRALARAARAAGVRIREGTPVTGLEreGGRVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLrpVRGYV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 260 VITDPAPDALAAQQLAHGRsvvdgrtfvHYYRSTPQGRLMLGkggntfAFANRHLAEFDAPSRYLAPLTRTLRRFFPALK 339
Cdd:COG0665   228 LVTEPLPDLPLRPVLDDTG---------VYLRPTADGRLLVG------GTAEPAGFDRAPTPERLEALLRRLRRLFPALA 292

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051267521 340 EVPIAASWCGASDRSVDGLPFFGHWRGQPNIVYGLGYSGNGVAQSWIGGQILAALVRDEVREED 403
Cdd:COG0665   293 DAEIVRAWAGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLD 356
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 30-394 1.66e-51

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 177.59  E-value: 1.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  30 DVCIVGGGFTGLWSAIALkqAEPHLRVMVLEKD-RCGSGASGRNGGCLLTWSAKYltlkrlfgeeQAAWLVQRSEQAVHE 108
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYEL--ARRGLSVTLLERGdDPGSGASGRNAGLIHPGLRYL----------EPSELARLALEALDL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 109 IARFCETHNIEAELRVEGTCYTATSEAQRGLMEpvLRELQRADLNQWQAIEEGELAS-QSGSHVHLEGLYSPHAGSVQPA 187
Cdd:pfam01266  69 WEELEEELGIDCGFRRCGVLVLARDEEEEALEK--LLAALRRLGVPAELLDAEELRElEPLLPGLRGGLFYPDGGHVDPA 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 188 LLVRGLLRVARELGVEVYEHSPMQRLEAGQPARVQTPQGEVRAskVVLALNS-AMVQHFREFRRSIVLVSSDMVITDPAP 266
Cdd:pfam01266 147 RLLRALARAAEALGVRIIEGTEVTGIEEEGGVWGVVTTGEADA--VVNAAGAwADLLALPGLRLPVRPVRGQVLVLEPLP 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 267 DALaaqqLAHGRSVVDGRTFVHYYRSTPQGRLMLGKGGNTFAFANrhlaeFDAPSRYLAPLTRTLRRFFPALKEvpIAAS 346
Cdd:pfam01266 225 EAL----LILPVPITVDPGRGVYLRPRADGRLLLGGTDEEDGFDD-----PTPDPEEIEELLEAARRLFPALAD--IERA 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2051267521 347 WCGASDrSVDGLPFFGHwRGQPNIVYGLGYSGNGVAQSWIGGQILAAL 394
Cdd:pfam01266 294 WAGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
30-234 6.11e-13

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 70.24  E-value: 6.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  30 DVCIVGGGFTGLWSAIALKQAEPHLRVMVLEK-DRCGSGASGRNGGCLltWSAKYLT---LKRLFGEEQAAWLVQrseqa 105
Cdd:PRK11728    4 DFVIIGGGIVGLSTAMQLQERYPGARIAVLEKeSGPARHQTGHNSGVI--HAGVYYTpgsLKARFCRRGNEATKA----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 106 vheiarFCETHNIEAElrVEGTCYTATSEAQRGLMEpvlRELQRADLNQWQA--IEEGELASQSGSHVHLEGLYSPHAGS 183
Cdd:PRK11728   77 ------FCDQHGIPYE--ECGKLLVATSELELERME---ALYERARANGIEVerLDAEELREREPNIRGLGAIFVPSTGI 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2051267521 184 VQPALLVRGLLRVARELGVEVYEHSPMQRL-EAGQPARVQTPQGEVRASKVV 234
Cdd:PRK11728  146 VDYRAVAEAMAELIQARGGEIRLGAEVTALdEHANGVVVRTTQGEYEARTLI 197
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
30-236 8.10e-12

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 66.71  E-value: 8.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  30 DVCIVGGGFTGLWSAIALKQAEpHLRVMVLEK-DRCGSGASGRNGGCLltWSAKYLTlkrlFGEEQAAWLVQRSEQavhe 108
Cdd:COG0579     6 DVVIIGAGIVGLALARELSRYE-DLKVLVLEKeDDVAQESSGNNSGVI--HAGLYYT----PGSLKARLCVEGNEL---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 109 IARFCETHNIEaeLRVEGTCYTATSEAQ---------RGLMEPV--LRELQRADLNQWQ-AIEEGELAsqsgshvhleGL 176
Cdd:COG0579    75 FYELCRELGIP--FKRCGKLVVATGEEEvafleklyeRGKANGVpgLEILDREELRELEpLLSDEGVA----------AL 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2051267521 177 YSPHAGSVQPALLVRGLLRVARELGVEVYEHSPMQRLE-AGQPARVQTPQGEVRASKVVLA 236
Cdd:COG0579   143 YSPSTGIVDPGALTRALAENAEANGVELLLNTEVTGIErEGDGWEVTTNGGTIRARFVINA 203
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 27-236 1.73e-09

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 59.46  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  27 HEADVCIVGGGFTGLWSAIALKQAEphLRVMVLEKDRCGSGASGRNGGcllTWSAKYLTLKRLFGEEQAAWLVQRSEQAV 106
Cdd:COG1053     2 HEYDVVVVGSGGAGLRAALEAAEAG--LKVLVLEKVPPRGGHTAAAQG---GINAAGTNVQKAAGEDSPEEHFYDTVKGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 107 HEIARfcethnieaELRVEGTCYTATseaqrglmePVLRELQRADLnQWQAIEEGELAsQSGSHVHLEGLYSPHAGSVQp 186
Cdd:COG1053    77 DGLAD---------QDLVEALAEEAP---------EAIDWLEAQGV-PFSRTPDGRLP-QFGGHSVGRTCYAGDGTGHA- 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2051267521 187 alLVRGLLRVARELGVEVYEHSPMQRL--EAGQP--ARVQTPQGE---VRASKVVLA 236
Cdd:COG1053   136 --LLATLYQAALRLGVEIFTETEVLDLivDDGRVvgVVARDRTGEivrIRAKAVVLA 190
solA PRK11259
N-methyl-L-tryptophan oxidase;
175-236 1.87e-06

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 49.83  E-value: 1.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2051267521 175 GLYSPHAGSVQPALLVRGLLRVARELGVEVYEHSPMQRLEA-GQPARVQTPQGEVRASKVVLA 236
Cdd:PRK11259  137 ALFEPDGGFLRPELAIKAHLRLAREAGAELLFNEPVTAIEAdGDGVTVTTADGTYEAKKLVVS 199
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
28-83 3.50e-05

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 46.16  E-value: 3.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2051267521  28 EADVCIVGGGFTGlwSAIALKQAEPHLRVMVLEKDRCGSGASGRNGGcLLTWSAKY 83
Cdd:PRK11101    6 ETDVIIIGGGATG--AGIARDCALRGLRCILVERHDIATGATGRNHG-LLHSGARY 58
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 8-245 3.60e-05

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 46.38  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521   8 LAEALAAEQPAP-PTPLHGHHEADVCIVGGGFTGLWSAIALkqAEPHLRVMVLEKD-RCGSGASG-RNGGCLLTWSAKYL 84
Cdd:PRK01747  239 LEQTLPAPLAAPwFARPGSPKARDAAIIGGGIAGAALALAL--ARRGWQVTLYEADeAPAQGASGnRQGALYPLLSKDDN 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  85 TLKRLFgeeQAAWL--VQRSEQAvheiarfcETHNIEAELRVEGTCYTATSEAQRGLMEPVLRELQRADLNQWQAIEEge 162
Cdd:PRK01747  317 ALSRFF---RAAFLfaRRFYDAL--------PAAGVAFDHDWCGVLQLAWDEKSAEKIAKMLALGLPAELARALDAEE-- 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 163 LASQSGSHVHLEGLYSPHAGSVQPALLVRGLLRVARElGVEVYEHSPMQRLEAGQPA-RVQTPQGEV-RASKVVLAlNSA 240
Cdd:PRK01747  384 AEELAGLPVPCGGIFYPQGGWLCPAELCRALLALAGQ-QLTIHFGHEVARLEREDDGwQLDFAGGTLaSAPVVVLA-NGH 461


                  ....*
gi 2051267521 241 MVQHF 245
Cdd:PRK01747  462 DAARF 466
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
29-60 4.52e-05

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 45.74  E-value: 4.52e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2051267521  29 ADVCIVGGGFTGLWSAIALKQAEPHLRVMVLE 60
Cdd:PRK07333    2 CDVVIAGGGYVGLALAVALKQAAPHLPVTVVD 33
PRK08275 PRK08275
putative oxidoreductase; Provisional
 27-73 7.95e-04

putative oxidoreductase; Provisional


Pssm-ID: 181346 [Multi-domain]  Cd Length: 554  Bit Score: 41.96  E-value: 7.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2051267521  27 HEADVCIVGGGFTGLWSAIALKQAEPHLRVMVLEK---DRCGSGASGRNG 73
Cdd:PRK08275    8 VETDILVIGGGTAGPMAAIKAKERNPALRVLLLEKanvKRSGAISMGMDG 57
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 31-78 1.10e-03

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 41.37  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2051267521  31 VCIVGGGFTGLWSAIALKQAEPHLRVMVLEkdrcgsgASGRNGGCLLT 78
Cdd:PRK11883    3 VAIIGGGITGLSAAYRLHKKGPDADITLLE-------ASDRLGGKIQT 43
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
33-92 1.21e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 37.13  E-value: 1.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2051267521  33 IVGGGFTGLWSAIALKQAepHLRVMVLEKDR--CGSGASGRNGGCLLTWSAKYLT------LKRLFGE 92
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKR--GFRVLVLEKRDrlGGNAYSYRVPGYVFDYGAHIFHgsdepnVRDLLDE 66
PRK06134 PRK06134
putative FAD-binding dehydrogenase; Reviewed
 189-236 2.93e-03

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 180419 [Multi-domain]  Cd Length: 581  Bit Score: 40.09  E-value: 2.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2051267521 189 LVRGLLRVARELGVEVYEHSPMQRL--EAGQP--ARVQTPQG--EVRASK-VVLA 236
Cdd:PRK06134  219 LVARLLKSAEDLGVRIWESAPARELlrEDGRVagAVVETPGGlqEIRARKgVVLA 273
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
24-237 4.73e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 39.13  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  24 HGHHEADVCIVGGGFTGLWSAIALKQAEphLRVMVLE-KDRCGsgasGRnggcllTWSAkYLTLKRLFGEEQAAWLVQRS 102
Cdd:COG1231     3 RRARGKDVVIVGAGLAGLAAARELRKAG--LDVTVLEaRDRVG----GR------VWTL-RFGDDGLYAELGAMRIPPSH 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 103 EQAVHEIARF-CETHNI-----EAELRVEG-TCYTATSEAQRGLMEPVLRELQR---ADLNQWQAIEEGE--------LA 164
Cdd:COG1231    70 TNLLALARELgLPLEPFpnengNALLYLGGkRVRAGEIAADLRGVAELLAKLLRalaAALDPWAHPAAELdreslaewLR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521 165 SQSGSHVHLEGL----------------------YSPHAGSVQPALLVRG-----LLRVARELGVEVYEHSPMQRLE-AG 216
Cdd:COG1231   150 RNGASPSARRLLgllgageygadpdelslldllrYAASAGGGAQQFRIVGgmdqlPRALAAELGDRIRLGAPVTRIRqDG 229

                         250       260
                  ....*....|....*....|..
gi 2051267521 217 QPARVQTPQG-EVRASKVVLAL 237
Cdd:COG1231   230 DGVTVTTDDGgTVRADAVIVTV 251
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 30-127 7.30e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 38.45  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051267521  30 DVCIVGGGFTGLWSAIALKQAEphLRVMVLEKDRCGSgasgrNGGCLLTwsaKYLTLKRLFGEEQAAW--LVQRSEQAVH 107
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLG--GKVTLIEDEGTCP-----YGGCVLS---KALLGAAEAPEIASLWadLYKRKEEVVK 71

                          90       100
                  ....*....|....*....|
gi 2051267521 108 EIarfceTHNIEAELRVEGT 127
Cdd:pfam07992  72 KL-----NNGIEVLLGTEVV 86
PRK09231 PRK09231
fumarate reductase flavoprotein subunit; Validated
 29-61 7.99e-03

fumarate reductase flavoprotein subunit; Validated


Pssm-ID: 236421 [Multi-domain]  Cd Length: 582  Bit Score: 38.85  E-value: 7.99e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2051267521  29 ADVCIVGGGFTGLWSAIALKQAEPHLRVMVLEK 61
Cdd:PRK09231    5 ADLAIIGAGGAGLRAAIAAAEANPNLKIALISK 37
PRK06854 PRK06854
adenylyl-sulfate reductase subunit alpha;
27-72 8.65e-03

adenylyl-sulfate reductase subunit alpha;


Pssm-ID: 235879 [Multi-domain]  Cd Length: 608  Bit Score: 38.75  E-value: 8.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2051267521  27 HEADVCIVGGGFTGLWSAIALKQAEPHLRVMVLEK---DRCGSGASGRN 72
Cdd:PRK06854   10 VDTDILIIGGGMAGCGAAFEAKEWAPDLKVLIVEKaniKRSGAVAQGLS 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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