|
Name |
Accession |
Description |
Interval |
E-value |
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
1-641 |
0e+00 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 875.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 1 MKKLNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGKMAGGIV 80
Cdd:COG0210 4 LAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALLGRLARGLW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 81 ISTFHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMREKDIDPKQCNPDTILWRISGAKNRLIGPQEF-KPLSDD 159
Cdd:COG0210 84 VGTFHSLALRILRRHAELLGLPPNFTILDGDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEELaELLAAD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 160 RIELATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLC 239
Cdd:COG0210 164 PEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLLAGDGRNLC 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 240 VVGDDDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAA 319
Cdd:COG0210 244 VVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWTDNGEGEKVRLYVAP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 320 SEEDEAEQVVEgMLMEQFKGNLSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSD 399
Cdd:COG0210 324 DEEEEARFVAD-EIRELHEEGVPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLANPDD 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 400 EASLLRIINFPRRGIGDGTLLHLNQWSMEHEVPLFEALGRVREIDGISESSKKAVAGFHEMMAGVIEGFnTRYGMGAQVN 479
Cdd:COG0210 403 DVALLRILNVPRRGIGAATLERLREAAREEGISLLEALRDLGELAGLSGRAAKALRRFAELLEALRAAA-ERLPLEELLE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 480 ALFNRLRIEDELYRtlNDAAQARKRIENIEQVVNSLAIYEEQNPRGTLSTFLERISL-MDEDKPSEDSkehglNAVTLMS 558
Cdd:COG0210 482 ALLDESGYEEELRE--EAGEEAERRLENLEELVDAAARFEERNPGASLEAFLEELALlSDLDAADEDE-----DAVTLMT 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 559 LHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDPTVAEERRLCYVGITRARRHLTISRCQTRRKYGATEQRTPSRFLDEIPE 638
Cdd:COG0210 555 LHAAKGLEFPVVFLVGLEEGLFPHQRSLDDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQDNEPSRFLDELPE 634
|
...
gi 2046543985 639 HLL 641
Cdd:COG0210 635 ELL 637
|
|
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
1-666 |
0e+00 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 745.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 1 MKKLNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGKMAGGIV 80
Cdd:TIGR01073 2 LAHLNPEQREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLIAEKNVAPWNILAITFTNKAAREMKERVEKLLGPVAEDIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 81 ISTFHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMREKDIDPKQCNPDTILWRISGAKNRLIGPQEFKPLSDDR 160
Cdd:TIGR01073 82 ISTFHSMCVRILRRDIDRIGINRNFSIIDPTDQLSLMKTILKDKNLDPKKFEPRSILGTISNAKNELLPPEDFAKEATNY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 161 IELATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCV 240
Cdd:TIGR01073 162 FEKVVAEVYQEYQKRLLRNNALDFDDLIMTTINLFQRVPDVLEYYQRKFQYIHVDEYQDTNRAQYTLVRLLASRFRNLCV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 241 VGDDDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAAS 320
Cdd:TIGR01073 242 VGDADQSIYGWRGADIQNILSFEKDYPNATTILLEQNYRSTKNILQAANEVIEHNSNRKPKNLWTENSSGDKITYYEADT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 321 EEDEAEQVVEGMLMEQFKGNLSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDE 400
Cdd:TIGR01073 322 ERDEAQFVAGEIDKLVKNGERKYGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILAYLRVIANPDDD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 401 ASLLRIINFPRRGIGDGTLLHLNQWSMEHEVPLFEALGRVREIDGISESSKKAVAGFHEMMAGVIEGFNtrygmGAQVNA 480
Cdd:TIGR01073 402 LSLLRIINVPKRGIGASSLEKIVNYALELNISLFEAIGEIDEIGGLAAKSANALLAFATMIENLRQQQE-----YLSPTE 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 481 LFnRLRIEDELYRTLNDAA---QARKRIENIEQVVNSLAIYEEQNPRGTLSTFLERISLMDEDKPSEDSKEHGlnAVTLM 557
Cdd:TIGR01073 477 LV-EEVLDKSGYREMLKAEkteEAQSRLENLDEFLSVTKEFEDESEDKSLIDFLTDLALVSDLDELEETEEGG--AVTLM 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 558 SLHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDPTVAEERRLCYVGITRARRHLTISRCQTRRKYGATEQRTPSRFLDEIP 637
Cdd:TIGR01073 554 TLHAAKGLEFPVVFLIGMEEGVFPHSRSLMDEKELEEERRLAYVGITRAEEELYLTHATMRTLFGRIQMNPPSRFLNEIP 633
|
650 660
....*....|....*....|....*....
gi 2046543985 638 EHLLITISSdtgDKEDKAVDLAADFFSRM 666
Cdd:TIGR01073 634 AELLETAST---GRRTGATDPKGPSIRQA 659
|
|
| rep |
TIGR01074 |
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. ... |
3-657 |
0e+00 |
|
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130146 [Multi-domain] Cd Length: 664 Bit Score: 683.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 3 KLNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGKM-AGGIVI 81
Cdd:TIGR01074 1 KLNPQQQEAVEYVTGPCLVLAGAGSGKTRVITNKIAYLIQNCGYKARNIAAVTFTNKAAREMKERVAKTLGKGeARGLTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 82 STFHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMrEKDIDPKQCNPDTILWRISGAKNRLIGPQEFKPLSDDRI 161
Cdd:TIGR01074 81 STFHTLGLDIIKREYNALGYKSNFSLFDETDQLALLKELT-EGLIKDDKDLLDKLISTISNWKNDLLTPEQALASARGER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 162 ELATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCVV 241
Cdd:TIGR01074 160 EQTFAHCYALYQAHLRAYNALDFDDLILLPTLLLQQNEEVRNRWQNKIRYLLVDEYQDTNTSQYELVKLLVGDRARFTVV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 242 GDDDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAASE 321
Cdd:TIGR01074 240 GDDDQSIYSWRGARPENLVLLKEDFPQLKVIKLEQNYRSTGRILKAANILIANNPHVFEKKLFSELGYGEKIKVIECNNE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 322 EDEAEQVVEGMLMEQFKGNLSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDEA 401
Cdd:TIGR01074 320 EHEAERIAGEIIAHKLVNKTQYKDYAILYRGNHQSRLLEKALMQNRIPYKLSGGTSFFSRPEIKDLLSYLRLLVNPDDDA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 402 SLLRIINFPRRGIGDGTLLHLNQWSMEHEVPLFEALGRVREIDGISESSKKAVAGFHEMMAGVIEgFNTRYGMGAQVNAL 481
Cdd:TIGR01074 400 AFLRIVNTPKREIGPATLEKLGELAMERNKSLFTASFDMGLLQTLSGRGYESLQRFTDWLVEIRR-LAERSEPIEAVRSL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 482 FNRLRIEDELYRTLNDAAQARKRIENIEQVVNSLA-IYEEQNPRG--TLSTFLERISLMD--EDKPSEDskehGLNAVTL 556
Cdd:TIGR01074 479 IEDIDYENWLYETSPSPKAAEMRMKNVNTLFSWFKeMLEGDEEDEpmTLTQVVTRLTLRDmlERGEDEE----ELDQVQL 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 557 MSLHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDpTVAEERRLCYVGITRARRHLTISRCQTRRKYGATEQRTPSRFLDEI 636
Cdd:TIGR01074 555 MTLHASKGLEFPYVFIVGMEEGILPHQSSIEED-NVEEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLDEL 633
|
650 660
....*....|....*....|.
gi 2046543985 637 PEHLLITissdtgDKEDKAVD 657
Cdd:TIGR01074 634 PQEDLQW------EGDDPVVS 648
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
4-641 |
0e+00 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 577.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 4 LNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGKMAGGIVIST 83
Cdd:PRK11773 10 LNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLLGTSQGGMWVGT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 84 FHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMREKDIDPKQCNPDTILWRISGAKNRLIGPQEFKPlSDDRIEL 163
Cdd:PRK11773 90 FHGLAHRLLRAHWQDANLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAQWYINGQKDEGLRPQHIQS-YGDPVEQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 164 ATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCVVGD 243
Cdd:PRK11773 169 TWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTNAIQYAWIRLLAGDTGKVMIVGD 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 244 DDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAASEED 323
Cdd:PRK11773 249 DDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNGRLGKELWTDGGDGEPISLYCAFNELD 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 324 EAEQVVEGMLMEQFKGNlSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDEASL 403
Cdd:PRK11773 329 EARFVVERIKTWQDNGG-ALSDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDALAYLRLIANRNDDAAF 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 404 LRIINFPRRGIGDGTLLHLNQWSMEHEVPLFEALGRVREIDGISESSKKAVAGFHEMMAGvIEGFNTRYGMGAQVNALFN 483
Cdd:PRK11773 408 ERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQACRALLQEKVLAGRAASALQRFIELIDA-LAQETADMPLHEQTDRVIK 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 484 R--LRiedELYRTLN-DAAQArkRIENIEQVVNSLAIY---EEQNPRGTLSTFLERISLmdedKPSEDSKEHGLNAVTLM 557
Cdd:PRK11773 487 DsgLR---AMYEQEKgEKGQA--RIENLEELVTATRQFsypDEDEDLTPLQAFLSHAAL----EAGEGQADAHEDAVQLM 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 558 SLHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDPTVAEERRLCYVGITRARRHLTISRCQTRRKYGATEQRTPSRFLDEIP 637
Cdd:PRK11773 558 TLHSAKGLEFPLVFIVGMEEGLFPSQMSLEEGGRLEEERRLAYVGITRAMQKLTLTYAESRRLYGKEVYHRPSRFIREIP 637
|
....
gi 2046543985 638 EHLL 641
Cdd:PRK11773 638 EECV 641
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
3-638 |
0e+00 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 558.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 3 KLNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAG-KMAGGIVI 81
Cdd:PRK10919 2 RLNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVAQTLGrKEARGLMI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 82 STFHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMR---EKDIDPKQcnpdTILWRISGAKNRLIGPQEFKPLSD 158
Cdd:PRK10919 82 STFHTLGLDIIKREYAALGMKSNFSLFDDTDQLALLKELTEgliEDDKVLLQ----QLISTISNWKNDLKTPAQAAAGAK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 159 DRIELATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNL 238
Cdd:PRK10919 158 GERDRIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 239 CVVGDDDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVA 318
Cdd:PRK10919 238 TVVGDDDQSIYSWRGARPQNLVLLSQDFPALQVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGDELKVLSA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 319 ASEEDEAEQVVEGMLMEQFKGNLSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPS 398
Cdd:PRK10919 318 NNEEHEAERVTGELIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 399 DEASLLRIINFPRRGIGDGTLLHLNQWSMEHEVPLFEA---LGRVREIDGISESSKKAvagFHEMMAGVIEgFNTRYGMG 475
Cdd:PRK10919 398 DDSAFLRIVNTPKREIGPATLQKLGEWAMTRNKSLFTAsfdMGLSQTLSGRGYESLTR---FTHWLAEIQR-LAEREPVA 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 476 AqVNALFNRLRIEDELYRTLNDAAQARKRIENIEQV---VNSLAIYEEQNPRGTLSTFLERISLMDEDKPSEDSKEhgLN 552
Cdd:PRK10919 474 A-VRDLIHGIDYESWLYETSPSPKAAEMRMKNVNQLfswMTEMLEGSELDEPMTLTQVVTRFTLRDMMERGESEEE--LD 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 553 AVTLMSLHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDpTVAEERRLCYVGITRARRHLTISRCQTRRKYGATEQRTPSRF 632
Cdd:PRK10919 551 QVQLMTLHASKGLEFPYVYLVGMEEGLLPHQSSIDED-NIDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRF 629
|
....*.
gi 2046543985 633 LDEIPE 638
Cdd:PRK10919 630 LLELPQ 635
|
|
| uvrD |
TIGR01075 |
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, ... |
4-641 |
4.60e-180 |
|
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130147 [Multi-domain] Cd Length: 715 Bit Score: 528.99 E-value: 4.60e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 4 LNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGKMAGGIVIST 83
Cdd:TIGR01075 5 LNDKQREAVAAPPGNLLVLAGAGSGKTRVLTHRIAWLLSVENASPHSIMAVTFTNKAAAEMRHRIGALLGTSARGMWIGT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 84 FHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMREKDIDPKQCNPDTILWRISGAKNRLIGPQEFKPLsDDRIEL 163
Cdd:TIGR01075 85 FHGLAHRLLRAHHLDAGLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAMWYINNQKDEGLRPSHIQAF-DNPVER 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 164 ATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCVVGD 243
Cdd:TIGR01075 164 TWIKIYQAYQEACDRAGLVDFAELLLRAHELLRNKPHILQHYQERFTHILVDEFQDTNKIQYAWIRLLAGNTGNVMIVGD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 244 DDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAASEED 323
Cdd:TIGR01075 244 DDQSIYGWRGAQVENIQKFLKDFPGAETIRLEQNYRSTANILAAANALIANNDERLGKNLWTDGEVGEPISLYSAFNELD 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 324 EAEQVVEGMLMEQFKGNlSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDEASL 403
Cdd:TIGR01075 324 EARFVVSRIKTWQRNGG-ALDECAVLYRSNAQSRVLEEALLQASIPYRIYGGMRFFERQEIKDALAYLRLIANRNDDAAF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 404 LRIINFPRRGIGDGTLLHLNQWSMEHEVPLFEALGRVREIDGISESSKKAVAGFHEMMAGVIEGfNTRYGMGAQVNALFN 483
Cdd:TIGR01075 403 ERVINTPTRGIGDRTLDVVRQAARDRGLTLWQAARELTQEKVLAGRAASALQRFVELIEALANE-TADMPLHVQTDHVIK 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 484 R--LRiedELYRTlNDAAQARKRIENIEQVVNSLAIY---EEQNPRGTLSTFLERISLmdedKPSEDSKEHGLNAVTLMS 558
Cdd:TIGR01075 482 DsgLR---EMYQQ-EKGEKGQARIENLEELVTATRQFslpENDEDMTPLTAFLSHAAL----EAGEGQADAGQDAVQLMT 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 559 LHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDPTVAEERRLCYVGITRARRHLTISRCQTRRKYGATEQRTPSRFLDEIPE 638
Cdd:TIGR01075 554 LHSAKGLEFPLVFLVGMEEGMFPSQMSLDEGGRLEEERRLAYVGITRAMQKLTITYAETRRLYGKEVYHIPSRFIRELPE 633
|
...
gi 2046543985 639 HLL 641
Cdd:TIGR01075 634 ECL 636
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
4-267 |
3.23e-112 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 338.45 E-value: 3.23e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 4 LNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGK-MAGGIVIS 82
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERILKLLGKaELSELNIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 83 TFHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMRE--KDIDPKQCNPDTILWRISGAKNRLIGPQEFKPLSDDR 160
Cdd:pfam00580 81 TFHSFCLRILRKYANRIGLLPNFSILDELDQLALLKELLEKdrLNLDPKLLRKLELKELISKAKNRLLSPEELQQGAADP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 161 IELATAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCV 240
Cdd:pfam00580 161 RDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHENLFL 240
|
250 260
....*....|....*....|....*..
gi 2046543985 241 VGDDDQSIYGWRGAEVQNILNFENDHA 267
Cdd:pfam00580 241 VGDPDQSIYGFRGADIENILKFEKDFP 267
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
3-620 |
8.06e-103 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 333.08 E-value: 8.06e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 3 KLNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGKMA------ 76
Cdd:COG1074 5 PWTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAEAAdledpd 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 77 ------------------GGIVISTFHSLGVRILRRDIRALGFKPNFSIySSSDQAGVLRQAMRE------KDIDPKQ-- 130
Cdd:COG1074 85 leelararrrlaralenlDRAAISTIHSFCQRLLREFAFEAGLDPNFEL-LDDAEALLLEEAVDDllreayAPLDALAla 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 131 -------CNPDTI---LWRISGAKNRLIGPQEFKPLSDDRIEL-------------------------------ATAAIY 169
Cdd:COG1074 164 rlldafgRDDDSLeelLLALYKLRSRPDWLEELAELDEALEALreallkakealaalrealaaaaapllaallrLLAAVL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 170 PRYQELLKGFNAIDFDDIIMLSVKLLQSNTA--ILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKH----GNLCVVGD 243
Cdd:COG1074 244 ARYERRKRERGLLDFDDLLHRALRLLRDEDApwVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEAladgRTLFLVGD 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 244 DDQSIYGWRGAEVQNILNFEND---HANCRVIKLEQNYRSTSAILEAANSV-----------IKNNPVRTDKA------- 302
Cdd:COG1074 324 PKQSIYRFRGADPELFLEARRAlegRVDGERLTLTTNFRSTPEVVDAVNALfaqlmgagfgeIPYEPVEALRPgaypave 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 303 LWSAVGKGREIDlivaASEEDEAEQVV--------EGMLMEQFKGNLSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIG 374
Cdd:COG1074 404 LWPLEPDDVSEE----DAREREARAVAarirrllaEGTTVEGGGRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAASD 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 375 GQQFYERKEVKDAIAYLKVIDNPSDEASLLRIINFPRRGIGDGTLLHLNQwsMEHEVPLFEALGRVREIdgisessKKAV 454
Cdd:COG1074 480 RLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSPLFGLSDEDLAALAA--DRKGESLWEALRAYERL-------ARAL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 455 AGFHEMMAGViegfnTRYGMGAQVNALFNRLRIEDELyRTLNDAAQARKRIENIEQVVNSLAIYEEQNPRGtLSTFLERI 534
Cdd:COG1074 551 ERLRALRELA-----RRLGLAELLERLLEETGLLERL-LALPGGERRLANLLHLDELLQLALEYEQTGGPG-LAGFLRWL 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 535 SLMDEDKPSEDSK--EHGLNAVTLMSLHSSKGLEFNHVWlvgmeedlLPHKRSIEEDPTVAEERRLCYVGITRARRHLTI 612
Cdd:COG1074 624 ERLIEDGGDEEKRrlESDADAVRIMTIHKSKGLEFPVVF--------LPALRERARAEELAEELRLLYVALTRARDRLVL 695
|
....*...
gi 2046543985 613 SRCQTRRK 620
Cdd:COG1074 696 SGAVKKKD 703
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
5-278 |
5.16e-92 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 283.25 E-value: 5.16e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 5 NPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGK-MAGGIVIST 83
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLLGEqLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 84 FHSLGVRILRRDIralgfkpnfsiysssdqagvlrqamrekdidpkqcnpdtilwrisgaknrligpqefkplsddriel 163
Cdd:cd17932 81 FHSFALRILRRYG------------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 164 ataaiypryqellkgfnaiDFDDIIMLSVKLLQSNTAILNHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCVVGD 243
Cdd:cd17932 94 -------------------DFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLFVVGD 154
|
250 260 270
....*....|....*....|....*....|....*
gi 2046543985 244 DDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNY 278
Cdd:cd17932 155 DDQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
272-617 |
5.58e-73 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 240.39 E-value: 5.58e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 272 IKLEQNYRSTSAILEAANSVIKNN----PVRTDKALWSAVGKGREIDLIVAASEEDEAEQVVEgMLMEQFKGNLSWSDMA 347
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNfgraTIYPKKILAETVEDGEKIKIIEAETEEEEAEWIAL-EIKKLVARDEKYNDIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 348 VLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDEASLLRIINFPRRGIGDGTLLHLNQWS- 426
Cdd:pfam13361 80 VLTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNGPKRGIGNATLERIREYKk 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 427 --MEHEVPLFEALGRVREIDGISESSKKAV------AGFHEMMAGVIEGFNTRYGMGAQVNALFNR-LRIE--------- 488
Cdd:pfam13361 160 rgLRLSDFINPDTLTYGDPFVIALEQDNIVvfdvetTGLDTTEDEIIQIAAIKLNKKGVVIESFERfLRLKkpvgdslqv 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 489 -----DELYRTLNDAAQARK----RIENIEQVVNSLA----IYEEQNPRGTLSTFLERISLmdedKPSEDSKEHGLNAVT 555
Cdd:pfam13361 240 hgfsdEFLQENGETPAEALRdfleKLENLRELYSILReyddIEETPEPEDALRNFLEIATL----SNSELEGSDIKERIP 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2046543985 556 LMSLHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDPTVAEERRLCYVGITRARRHLTISRCQT 617
Cdd:pfam13361 316 IMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIKDEGNLEEERRLFYVAITRAKKRLYISYSKS 377
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
8-610 |
7.73e-36 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 145.23 E-value: 7.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 8 QQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKrIPADNILAVTFTNKAAREMKERVSNMAGK------------- 74
Cdd:TIGR02785 6 QWQAIYTRGQDILVSASAGSGKTAVLVERIIRKITRG-VDVDRLLVVTFTNAAAREMKERIAEALEKelvqepnskhlrr 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 75 ---MAGGIVISTFHSLGVRILRRDIRALGFKPNFSIYSSSDQAGVLRQAMRE-------------------------KDI 126
Cdd:TIGR02785 85 qlaLLNTANISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDvfeeeyykedkeaffelvdnfsgdrSDD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 127 DPK----------QCNPDTILW-------------------------------RISGAKNRLIGPQEF------------ 153
Cdd:TIGR02785 165 GLRdlilqlydfsRSTPNPEKWlnnlaeayevkekftieslklqqqikellknELEGLQEKLQRALELfmaedglaprle 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 154 ---------------KPLSDDRIELAT-------------------AAIYP----------------------------- 170
Cdd:TIGR02785 245 nfqldlqnideliqeSLAQADWNELRKavaafkfknlkaakgdeedADLLEeadklreeakkqleklktdyftrseedhl 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 171 ----------------------RYQELLKGFNAIDFDDIIMLSVKLLQSNT----AILNHWQERFQYIMVDEYQDTNASQ 224
Cdd:TIGR02785 325 rimqemkpvvktlvqlvkdfieRFGAEKREKNILDFSDLEHYALQILTNENespsEAAEFYREKFHEVLVDEYQDTNLVQ 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 225 YLLISLLAK---KHGNLCVVGDDDQSIYGWRGAEVQNILNFENDHANC-----RVIKLEQNYRSTSAILEAANSVIK--- 293
Cdd:TIGR02785 405 ESILQLVKRgpeEEGNLFMVGDVKQSIYRFRQADPLLFLEKYHRFAQEgeehgKRIDLAENFRSRAEVLDTTNFLFKqlm 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 294 ------------------------NNPVRTDKALWS--AVGKGREIDLIVAASEEDEAEQVVEgMLMEQFKG-------- 339
Cdd:TIGR02785 485 deevgeidydeeaqlkfgaakypeNPDNKTEELLYEklLIEEAEEEEIDEEAEILDKAQQEAT-MVAERIKAlikegfkv 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 340 ---------NLSWSDMAVLYRSNAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDEASLLRIINFP 410
Cdd:TIGR02785 564 ydkktgtyrPVTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPLVAVLRSP 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 411 RRGIGDGTLlhlnqwsmehevplfeALGRVREIDGISESSKKAVAGFHEMMAGVIEGFNTRYGMGAQVNALFNRLRIEDE 490
Cdd:TIGR02785 644 IVGFDENEL----------------ALIRLENKDSSYYEAVKDYVKAGLIEDELYEKLNTFLDSLQKWREFARTHSVSEL 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 491 LYRTLNDAA---------QARKRIENIEQVVNSLAIYEEQNPRGtLSTFLERISLM---DEDKPSEDSKEHGLNAVTLMS 558
Cdd:TIGR02785 708 IWKIYNDTGyydyvgglpGGKQRQANLYALYERARQYESTSFKG-LFQFIRFIERMqerQKDLASAVAVGEAENAVRLMT 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 559 LHSSKGLEFNHVWLVGMEED----------------------LLPHKR-SIEEDPTVA-----------EERRLCYVGIT 604
Cdd:TIGR02785 787 IHKSKGLEFPVVFVLGMGKQfnkqdlnssylldrqlglgikyIDPQERlSYPSLPKVAikqkmkrellsEEMRVLYVALT 866
|
....*.
gi 2046543985 605 RARRHL 610
Cdd:TIGR02785 867 RAKEKL 872
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
4-305 |
5.59e-35 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 141.24 E-value: 5.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 4 LNPPQQQAVQNTEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPADNILAVTFTNKAAREMKERVSNMAGkmAGGIVIST 83
Cdd:PRK11054 197 LNPSQARAVVNGEDSLLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEEMDERIRERLG--TEDITART 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 84 FHSLGVRILRRDIRAlgfKPNFSIYSSSDQA------GVLRQAMREK-----------------DIDPKQ--CNPDTILW 138
Cdd:PRK11054 275 FHALALHIIQQGSKK---VPVISKLENDSKArhalliAEWRKQCSEKkaqakgwrqwlteelqwDVPEGNfwDDEKLQRR 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 139 ---RIS----------GAKNRLI--GPQEFKPLSDDRIELaTAAIYPRYQELLKGFNAIDFDDIIMLSVKLLQSNtailn 203
Cdd:PRK11054 352 lasRLErwvslmrmhgGSQAEMIaqAPEEVRDLFQKRLKL-MAPLLKAWKKALKAENAVDFSGLIHQAVNYLEKG----- 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 204 hwqeRF----QYIMVDEYQDTNASQYLLISLLAKK--HGNLCVVGDDDQSIYGWRGAEVQNILNFENDHANCRVIKLEQN 277
Cdd:PRK11054 426 ----RFispwKHILVDEFQDISPQRAALLAALRKQnsQTTLFAVGDDWQAIYRFSGADLSLTTAFHERFGEGDRCHLDTT 501
|
330 340
....*....|....*....|....*...
gi 2046543985 278 YRSTSAILEAANSVIKNNPVRTDKALWS 305
Cdd:PRK11054 502 YRFNSRIGEVANRFIQQNPHQLKKPLNS 529
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
280-613 |
2.74e-24 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 99.23 E-value: 2.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 280 STSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAASEEDEAEQVVEGMLMEQFKGNLSWSDMAVLYRSNAQSRAF 359
Cdd:cd18807 1 STKNILDAANSLIKQNKNRPKKPLKAGNKSGGPVELLLAKDEADEAKAIADEIKRLIESGPVQYSDIAILVRTNRQARVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 360 EERLRqeripyvviggqqfyerkevkdaiaylkvidnpsdeasllriinfprrgigdgtllhlnqwsmehevplfealgr 439
Cdd:cd18807 81 EEALR--------------------------------------------------------------------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 440 vreidgisesskkavagfhemmagviegfntrygmgaqvnalfnrlriedelyrtlndaaqarkrienieqvvnslaiye 519
Cdd:cd18807 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 520 eqnprgtlstflerislmdedkpsedskehglnaVTLMSLHSSKGLEFNHVWLVGMEEDLLPHKRSIEEDP----TVAEE 595
Cdd:cd18807 86 ----------------------------------VTLMTIHASKGLEFPVVFIVGLGEGFIPSDASYHAAKedeeRLEEE 131
|
330
....*....|....*...
gi 2046543985 596 RRLCYVGITRARRHLTIS 613
Cdd:cd18807 132 RRLLYVALTRAKKELYLV 149
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
20-667 |
2.09e-21 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 99.43 E-value: 2.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 20 LLLAGAGSGKTQVITTRIVHLLKDKRipadNILAVTFTNKAAREMKERVSNMAGKMAGGIVISTFHSLGVRILRRDIRAl 99
Cdd:COG3857 2 FILGRAGSGKTTYLLEEIKEELKEGK----PIILLVPEQMTFQAERALLKRLGLGGSIRAQVLSFSRLAWRVLQETGGA- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 100 gfkpNFSIYSSSDQAGVLRQAMREKDIDPKQCNP--------DTILWRISGAKNRLIGPQEFKPLSDDRIELAT--AAIY 169
Cdd:COG3857 77 ----TRPLLSDAGKRMLLRKILEEHKDELKVFARaadkpgfiEQLAELITELKRYGITPEDLEEAAELLKEKLRdlALIY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 170 PRYQELLKGfNAIDFDDIIMLSVKLLQSNTAILNHwqerfqYIMVDEYQDTNASQYLLISLLAKKHGNLCVVGDDDQSIY 249
Cdd:COG3857 153 EAYEEKLAG-RYIDSEDLLRLLAEKLEKSEFLEGA------EIYIDGFTDFTPQELELLEALLKKAKEVTITLTLDPDEL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 250 GWRGAEVQNILNFENDhANCRVIKLEQNYRSTSAILEAAnsvIKNNPVRTDKAlwsavgkgrEIDLIVAASEEDEAEQVV 329
Cdd:COG3857 226 DLFSATGETYERLLEL-AKENGVEVEFKKSPELAHLERN---LFAYPPEEEPE---------GIEIIEAANRRAEVEAVA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 330 EGMLMEQFKGNLSWSDMAVLYRS-NAQSRAFEERLRQERIPYVVIGGQQFYERKEVKDAIAYLKVIDNPSDEASLLRII- 407
Cdd:COG3857 293 REIRRLVREEGYRYRDIAVVVRDlEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVRSNFRYEDVFRLLk 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 408 -----NFPRRGIgDGTLLHLNQWSMEHEVPLFEALGRVREIDGISESSKKAVAGFHEMMAGVIEGFNTRYG----MGAQV 478
Cdd:COG3857 373 tgllrPLSREEI-DRLENYVLAYGIRGRRWLERYLEEEEELTDEEEEDLERLNELRDRLLEPLLPLRERLKkaktVREWA 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 479 NALFN---RLRIEDELYR-TLNDAAQARKRIENIEQVVNSL--------AIYEEQNPrgTLSTFLERI-SLMDEDKPSED 545
Cdd:COG3857 452 EALYEfleELGVPEKLEEwREAEEAGDLEEAREHEQAWNALielldelvEVLGDEKL--SLEEFLRILeSGLEELTFGLI 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 546 SKehGLNAVTLMSLHSSKGLEFNHVWLVGMEEDLLPhkRSIEEDP-----------------------TVAEERRLCYVG 602
Cdd:COG3857 530 PP--SLDQVQVGGLDRARGLDFKAVFVLGLNEGVFP--ARPREDGllsdeererlnelglelpptsreRLLEERFLFYRA 605
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2046543985 603 ITRARRHLTISRCQTRRKygaTEQRTPSRFLDEIPEHLLITISSDTGDKEDKAVDLAADFFSRML 667
Cdd:COG3857 606 LTRASERLYLSYPLADEE---GKALLPSPLIDRLRELFPELEERSLLEEELEYIGTPESALSELA 667
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
139-612 |
5.44e-18 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 88.59 E-value: 5.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 139 RISGAKNRLigpQEFKPLSDDRIELATAAIY-PRYQELLKGFNAIDFDDIIMLSVKLLQSNTAilNHWqerFQY------ 211
Cdd:TIGR02784 320 RVEALRERL---RALRMAQRTLAALRLAARLlQRYARLKKARGLLDFNDLIERTVALLARPGA--GAW---VHYkldrgi 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 212 --IMVDEYQDTNASQYLLISLLAKK-----------HGNLCVVGDDDQSIYGWRGAEVQNILN--------FENDHANCR 270
Cdd:TIGR02784 392 dhILVDEAQDTSPEQWDIIQALAEEffsgegarsgvERTIFAVGDEKQSIYSFQGADPERFAEerrefsrkVRAVGRKFE 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 271 VIKLEQNYRSTSAILEAANSVIKN----------------NPVRTDKA----LWSAVGK--GREID--------LIVAAS 320
Cdd:TIGR02784 472 DLSLNYSFRSTPDVLAAVDLVFADpenarglsadsdapvhEAFRDDLPgrvdLWDLISKeeGEEPEdwtdpvdeLGERAP 551
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 321 EEDEAEQV---VEGML----MEQFKG-NLSWSDMAVLYRS-----NAQSRAfeerLRQERIPyvVIGGQQFYERKE--VK 385
Cdd:TIGR02784 552 EVRLAERIaaeIRAWLdrgtPIPGRGrAVRPGDILVLVRKrdaffSALIRA----LKRRGIP--VAGADRLKLTSHiaVK 625
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 386 DAIAYLKVIDNPSDEASLLRIINFPRRGIGDGTLLHLNQwsMEHEVPLFEALGRVReidgisesskkavAGFHEMMagvi 465
Cdd:TIGR02784 626 DLMALGRFVLQPEDDLSLAALLKSPLFGLDEDDLFRLAA--GRSGGSLWAALRRRE-------------AEFAATL---- 686
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 466 egfntrygmgAQVNALFNRLRIED--ELYRTLNDAAQARKRI-----ENIEQVVN---SLAIYEEQNPRGTLSTFLERIS 535
Cdd:TIGR02784 687 ----------AVLRDWLSLADFLTpfEFYARLLGRDGGRRKLlarlgAEAEDILDeflSQALAYERTGLPGLQAFLSWLE 756
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 536 LMDEDKPSEDSKEHglNAVTLMSLHSSKGLE-------------FNH-----------------VWLVGMEEDLLPHKRS 585
Cdd:TIGR02784 757 ADDPEIKREMDQAR--DEVRVMTVHGAKGLEapvvflvdtgskpFASqraplllatggsggkapLWRPASAFDPSLSAAA 834
|
570 580
....*....|....*....|....*....
gi 2046543985 586 IEEDPTVAEE--RRLCYVGITRARRHLTI 612
Cdd:TIGR02784 835 RERLKERAEDeyRRLLYVAMTRAEDRLIV 863
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
203-278 |
1.77e-17 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 78.68 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 203 NHWQERFQYIMVDEYQDTNASQYLLISLLAKKHGNLCVVGDDDQSIYGWRGAEVQNILN-----FENDHANCRVIKLEQN 277
Cdd:cd17914 41 NKAAAQLDNILVDEAAQILEPETSRLIDLALDQGRVILVGDHDQLGPVWRGAVLAKICNeqslfTRLVRLGVSLIRLQVQ 120
|
.
gi 2046543985 278 Y 278
Cdd:cd17914 121 Y 121
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
8-252 |
1.42e-16 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 76.87 E-value: 1.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 8 QQQAVQN--TEGPLLLLAGAGSGKTQVITTRIVHLLKDKRIPaDNILAVTFTNKAAREMKERVsnmagkmagGIVISTFH 85
Cdd:pfam13245 1 QREAVRTalPSKVVLLTGGPGTGKTTTIRHIVALLVALGGVS-FPILLAAPTGRAAKRLSERT---------GLPASTIH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 86 SLgvrilrrdiralgfkpnfsiysssdqagvlrqamrekdidpkqcnpdtilwrisgaknrligpqefkplsddrielat 165
Cdd:pfam13245 71 RL------------------------------------------------------------------------------ 72
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 166 aaiypryqellkgfnaIDFDDIIMLSVKllqsntaILNHWQERFQYIMVDEYQDTNA-SQYLLISLLAKKHGnLCVVGDD 244
Cdd:pfam13245 73 ----------------LGFDDLEAGGFL-------RDEEEPLDGDLLIVDEFSMVDLpLAYRLLKALPDGAQ-LLLVGDP 128
|
....*...
gi 2046543985 245 DQSIYGWR 252
Cdd:pfam13245 129 DQLPSVGP 136
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
19-570 |
2.21e-16 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 83.48 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 19 LLLLAGAGSGKTQVITTRIVHLLKDKRIPADnILAVTFTNKAAREMKERV-------------------SNMAGK----- 74
Cdd:PRK13909 1 LALKASAGSGKTFALSVRFLALLFKGANPSE-ILALTFTKKAANEMKERIidtllnlekekeeselnelEEKLGLskeel 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 75 -----------MAGGIVISTFHSLGVRILRRDIRALGFKPNFSI------------------------------YSSSDQ 113
Cdd:PRK13909 80 lnkrdkvyqefLNSELKISTIDAFFQKILRKFCLNLGLSPDFSIkedtkeelnekflsalskeellellafikqCESKKN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 114 AGVLR--QAMREKDIDPKQCNPDT----------------ILWRISGAKN--------------------------RLIG 149
Cdd:PRK13909 160 NSFFEllEKLYEKNNELKLFEKAKnpiefdeekfleelrsLKQQIQSIETasknakkafkkedfeellnssktwleKESE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 150 PQEFK-----PLSDDRIELATAA-----------------IYPRYQE----LLKGFNAIDFDDIIMLSVKLLQSNT---- 199
Cdd:PRK13909 240 YRYFKklyneELDAEFEELKNALkryydakenyklsklfkLLQLYKEakneLNKKKNALDFDDISKKVYELLGEEEidkd 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 200 AILNHWQERFQYIMVDEYQDTNASQY-LLISLLA--------KKHGNLCVVGDDDQSIYGWRG--AEVqnilnFE---ND 265
Cdd:PRK13909 320 FLYFRLDSKISHILIDEFQDTSVLQYkILLPLIDeiksgegqKKFRSFFYVGDVKQSIYRFRGgkKEL-----FDkvsKD 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 266 HaNCRVIKLEQNYRSTSAILEAANSVIKNNPVRTDKALWSAVGKGREIDLIVAASEEDE-AEQVVE--GMLMEQfkgNLS 342
Cdd:PRK13909 395 F-KQKVDNLDTNYRSAPLIVDFVNEVFKKKYKNYKTQYAEQHKSGGYVEVVEVADESEElLEQLLQeiQFLLEK---GID 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 343 WSDMAVLYRSNAQSRAFEERLRQER-IPYVVIGGQQFYERKEVKDAIAYLKVI--DNPSDEASLLRIINFPrrgigdgtl 419
Cdd:PRK13909 471 PDDIAILCWTNDDALEIKEFLQEQFgIKAVTESSAKLINQPEVKALIEALKYClfGEEIYKHNVLKLLGKE--------- 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 420 lhlnqwsmehevplfeaLGRVREIDgiseSSKKAVAGFhemmagviegfntrygmgaqVNALFNRLRIEDELYRTLNDAA 499
Cdd:PRK13909 542 -----------------PDKIPSFL----PKEESVAEF--------------------VKKLIEELKLYDENLLKFLELA 580
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2046543985 500 qarKRIENIEqvvnslaiyeeqnprgtlsTFLERISLMDEDKPSEDSKehglnAVTLMSLHSSKGLEFNHV 570
Cdd:PRK13909 581 ---SGYEDIE-------------------EFLFKLEPCDKEIASEESK-----GVQIMTVHKSKGLEFEHV 624
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
8-385 |
5.15e-14 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 75.25 E-value: 5.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 8 QQQ--AVQNTEGPLLLLAGAGSGKTQVITTRIVHLLkdKRIPADNILAVTFTNKAAREMKERVSNMAGKMAGG-----IV 80
Cdd:COG3972 163 QQEriARSIPDGPQRIRGVAGSGKTVLLAAKAAYLA--LKHPGWRILVTCFNRSLADHLRDLIPRFLRRFSNGepednVK 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 81 ISTFHSLGVRILRrdiralgfkpnfsiysssdQAGvlrqamrekdidpkqcnpdtilwrisgaknrlIGPQEFKPLSDDR 160
Cdd:COG3972 241 LIVFHAWGGKLLK-------------------QYG--------------------------------IPPLTFSQPNEAF 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 161 IELATAAIypryqellkgfNAIDFDDIimlsvkllqsntailnhwQERFQYIMVDEYQDTNASQY-LLISLLAKKHGNLC 239
Cdd:COG3972 270 DEACKALL-----------EAIQGEII------------------PPIYDAILIDEAQDFEPEFLrLLYQLLKPPKKRLI 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 240 VVGDDDQSIYGWRGAEVQNILNFENdhancRVIKLEQNYRSTSAILEAANSV---------------------IKNNPVR 298
Cdd:COG3972 321 WAYDEAQNIYGRKIPSAGGIPAGIG-----RDTILKKNYRNTRPILTFAHAFgmgllrppgllqgdaedyeveRPGDKVT 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 299 TDKALWSAVGKGREIDLIVAASEEDEAEQVVEGMLMEQFKGNLSWSDMAVLYRSNAQSRAFEER----LRQERIPYVVIG 374
Cdd:COG3972 396 LIRPPEPAGRKGPLPEFKKYDDRAEELEAIAEEIKKNLRDEGLRPSDIAVIYLGNNEAKELGDRlaaaLERQGIDSYIAG 475
|
410
....*....|....*
gi 2046543985 375 GQ----QFYERKEVK 385
Cdd:COG3972 476 ARsdpnFFWKDGGVT 490
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
206-377 |
3.57e-12 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 69.51 E-value: 3.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 206 QERFQYIMVDEYQDTNASQYLLISLLAKkHGNLCVVGDDDQSIYGWRGAEVQNILNFENDHANCRVIKLEQNYRSTSAIL 285
Cdd:COG3973 467 TWTYGHVVVDEAQDLSPMQWRVLKRRFP-SASFTIVGDLAQAIHPYRGAESWEEVLEPLGGDRARLVELTKSYRSTAEIM 545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 286 EAANSVIKNNPVRTDKALwSAVGKGREIDLIVAASEEDEAEQVVEgmLMEQFKGNLSWSdMAVLYRSNAQSRAFEERLrQ 365
Cdd:COG3973 546 EFANRVLRAAGPDLPPPE-SVRRHGEPPRVVRVPSEAELAAAVVE--AVRELLAEGEGT-IAVICKTAREAEALYAAL-K 620
|
170
....*....|..
gi 2046543985 366 ERIPYVVIGGQQ 377
Cdd:COG3973 621 AGLPVTLIDDES 632
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
524-612 |
2.84e-09 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 54.37 E-value: 2.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 524 RGTLSTFLERISLMDEDkpsedskehgLNAVTLMSLHSSKGLEFNHVWLVGMEEDLLphkrsieedptvaeERRLCYVGI 603
Cdd:cd18786 23 RAYLNQYLQGLSLDEFD----------LQLVGAITIDSSQGLTFDVVTLYLPTANSL--------------TPRRLYVAL 78
|
....*....
gi 2046543985 604 TRARRHLTI 612
Cdd:cd18786 79 TRARKRLVI 87
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
554-612 |
6.80e-08 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 49.11 E-value: 6.80e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2046543985 554 VTLMSLHSSKGLEFNHVWLVGMEEDLLPHkrsieedptVAEERRLCYVGITRARRHLTI 612
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVFLVDPDLTAHYH---------SMLRRRLLYTAVTRARKKLVL 51
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
184-289 |
1.58e-06 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 51.51 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 184 FDDiiMLSvKL---LQSN------TAIlnhwQERFQYIMVDEYQDTNASQYLLI-SLLAKKHGN-LCVVGDDDQSIYGWR 252
Cdd:PRK10876 351 FDD--LLS-RLdsaLQSEggealaAAI----RTRYPVAMIDEFQDTDPQQYRIFrRIYRHQPETaLLLIGDPKQAIYAFR 423
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2046543985 253 GAEVqnilnFENDHANCRV---IKLEQNYRSTSAILEAAN 289
Cdd:PRK10876 424 GADI-----FTYMKARSEVsahYTLDTNWRSAPGMVNSVN 458
|
|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
557-612 |
5.21e-06 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 44.86 E-value: 5.21e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2046543985 557 MSLHSSKGLEFNHVWLVgmeedlLPHKRSIEEdptvaeeRRLCYVGITRARRHLTI 612
Cdd:cd18809 36 MTIHKSQGSEFDRVIVV------LPTSHPMLS-------RGLLYTALTRARKLLTL 78
|
|
| recD |
PRK10875 |
exodeoxyribonuclease V subunit alpha; |
557-612 |
1.31e-04 |
|
exodeoxyribonuclease V subunit alpha;
Pssm-ID: 236783 [Multi-domain] Cd Length: 615 Bit Score: 45.32 E-value: 1.31e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2046543985 557 MSLHSSKGLEFNHVWLVgmeedlLPHKRSieedPTVAeeRRLCYVGITRARRHLTI 612
Cdd:PRK10875 542 MTVHKSQGSEFDHTALV------LPNQFT----PVVT--RELVYTAITRARRRLSL 585
|
|
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
4-70 |
2.65e-04 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 42.99 E-value: 2.65e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2046543985 4 LNPPQQQAVQN------TEGPLLLLAGAGSGKTQVITTRIVHLLKDKriPADNILAVTFTNKAAREMKERVSN 70
Cdd:cd18038 2 LNDEQKLAVRNivtgtsRPPPYIIFGPPGTGKTVTLVEAILQVLRQP--PEARILVCAPSNSAADLLAERLLN 72
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
551-612 |
7.86e-04 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 42.66 E-value: 7.86e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2046543985 551 LNAVTL---MSLHSSKGLEFNHVWLVgmeedllphkrsIEEDPTVAEERRLCYVGITRARRHLTI 612
Cdd:COG0507 436 LDQLELayaITVHKSQGSTFDRVILV------------LPSEHSPLLSRELLYTALTRARELLTL 488
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
3-87 |
8.28e-04 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 42.27 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543985 3 KLNPPQQQAVQ---NTEGPLLLLAGAGSGKTQVItTRIVHLLKDKRIpadNILAVTFTNKAAREMKErvsnmagkmAGGI 79
Cdd:COG0507 124 TLSDEQREAVAlalTTRRVSVLTGGAGTGKTTTL-RALLAALEALGL---RVALAAPTGKAAKRLSE---------STGI 190
|
....*...
gi 2046543985 80 VISTFHSL 87
Cdd:COG0507 191 EARTIHRL 198
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
19-64 |
2.22e-03 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 37.50 E-value: 2.22e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2046543985 19 LLLLAGAGSGKTQVITTRIVHLLKDKRipadNILAVTFTNKAAREM 64
Cdd:cd17912 2 ILHLGPTGSGKTLVAIQKIASAMSSGK----SVLVVTPTKLLAHEI 43
|
|
| |
