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glycine cleavage system protein GcvH [Pelotalea chapellei]

Protein Classification

glycine cleavage system protein H( domain architecture ID 10785558)

glycine cleavage system protein H plays a role in the degradation of glycine by shuttling the methylamine group of glycine from P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase).

EC:  1.4.1.27
Gene Ontology:  GO:0019464|GO:0009249|GO:0005960
PubMed:  20375021|18941301

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 1-125 3.48e-59

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440275  Cd Length: 128  Bit Score: 178.39  E-value: 3.48e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   1 MDFPEELKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:COG0509     1 MEIPDDLKYTEDHEWVRVEGDGtATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2046543957  80 NHEAVDNPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:COG0509    81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLE 126
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 1-125 3.48e-59

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 178.39  E-value: 3.48e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   1 MDFPEELKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:COG0509     1 MEIPDDLKYTEDHEWVRVEGDGtATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2046543957  80 NHEAVDNPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:COG0509    81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLE 126
PRK01202 PRK01202
glycine cleavage system protein GcvH;
1-125 3.60e-53

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 163.02  E-value: 3.60e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   1 MDFPEELKYSKEHIWVRVEHDAAVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVN 80
Cdd:PRK01202    2 MNIPADLKYTKSHEWVRVEGDTATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEVN 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2046543957  81 HEAVDNPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:PRK01202   82 EALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEALIE 126
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 7-125 1.65e-43

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 138.62  E-value: 1.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   7 LKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEAVD 85
Cdd:pfam01597   1 LYYTKEHEWVKVEGDGtATVGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2046543957  86 NPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:pfam01597  81 NPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEKTLK 120
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 4-120 8.70e-42

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 134.58  E-value: 8.70e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   4 PEELKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHE 82
Cdd:TIGR00527   3 PQDLRYSSEHEWVRVEGDKtATVGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVVEVNTA 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2046543957  83 AVDNPGVLNDDPYDSGWLVEVSLDDI-DELKGLMSAEDY 120
Cdd:TIGR00527  83 LEDSPELVNEDPYGDGWLIKVKLSDGeSEVEGLMSAEQY 121
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 9-103 1.87e-41

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 132.66  E-value: 1.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   9 YSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEAVDNP 87
Cdd:cd06848     1 YTKDHEWVKVEGDGiATVGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNP 80

                          90
                  ....*....|....*.
gi 2046543957  88 GVLNDDPYDSGWLVEV 103
Cdd:cd06848    81 ELINSDPYGEGWLVKI 96
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 1-125 3.48e-59

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 178.39  E-value: 3.48e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   1 MDFPEELKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:COG0509     1 MEIPDDLKYTEDHEWVRVEGDGtATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2046543957  80 NHEAVDNPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:COG0509    81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLE 126
PRK01202 PRK01202
glycine cleavage system protein GcvH;
1-125 3.60e-53

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 163.02  E-value: 3.60e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   1 MDFPEELKYSKEHIWVRVEHDAAVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVN 80
Cdd:PRK01202    2 MNIPADLKYTKSHEWVRVEGDTATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEVN 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2046543957  81 HEAVDNPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:PRK01202   82 EALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEALIE 126
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 7-125 1.65e-43

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 138.62  E-value: 1.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   7 LKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEAVD 85
Cdd:pfam01597   1 LYYTKEHEWVKVEGDGtATVGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2046543957  86 NPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYADYVE 125
Cdd:pfam01597  81 NPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEKTLK 120
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 4-120 8.70e-42

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 134.58  E-value: 8.70e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   4 PEELKYSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHE 82
Cdd:TIGR00527   3 PQDLRYSSEHEWVRVEGDKtATVGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVVEVNTA 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2046543957  83 AVDNPGVLNDDPYDSGWLVEVSLDDI-DELKGLMSAEDY 120
Cdd:TIGR00527  83 LEDSPELVNEDPYGDGWLIKVKLSDGeSEVEGLMSAEQY 121
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 9-103 1.87e-41

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 132.66  E-value: 1.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   9 YSKEHIWVRVEHDA-AVIGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEAVDNP 87
Cdd:cd06848     1 YTKDHEWVKVEGDGiATVGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNP 80

                          90
                  ....*....|....*.
gi 2046543957  88 GVLNDDPYDSGWLVEV 103
Cdd:cd06848    81 ELINSDPYGEGWLVKI 96
PRK13380 PRK13380
glycine cleavage system protein H; Provisional
 4-122 8.46e-29

glycine cleavage system protein H; Provisional


Pssm-ID: 237370  Cd Length: 144  Bit Score: 102.00  E-value: 8.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   4 PEELKYSKE-HIWVRVEHDAAV-IGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNH 81
Cdd:PRK13380   10 PSELRYTIKnHEWLRLEGDGTVtVGITDYAQTMAGDVVFVRLKELGKKVEKGKPVATLESGKWAGPVPAPLTGEVVEVNE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2046543957  82 EAVDNPGVLNDDPYDSGWLVEVSLDDIDELKGLMSAEDYAD 122
Cdd:PRK13380   90 ALEDSPELVNEDPYGEGWFFRFKPANPEELKQLLDGDAADR 130
PRK00624 PRK00624
glycine cleavage system protein H; Provisional
 9-107 8.45e-14

glycine cleavage system protein H; Provisional


Pssm-ID: 167014  Cd Length: 114  Bit Score: 62.92  E-value: 8.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046543957   9 YSKEHIWVRVEHDAAV-IGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEAVDNP 87
Cdd:PRK00624    4 YSDYHVWIEPIHSRIVrLGLTSKMQENLGNILHIDLPSVGSFCKEGEVLVILESSKSAIEVLSPVSGEVIEVNTALEDDI 83

                          90       100
                  ....*....|....*....|
gi 2046543957  88 GVLNDDPYDSGWLVEVSLDD 107
Cdd:PRK00624   84 QPINNAPESEGWFVVVQLDE 103
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 25-103 5.92e-09

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 48.98  E-value: 5.92e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2046543957  25 IGITDFAQEELGAISGVNLPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEavdnpgvLNDDPYDSGWLVEV 103
Cdd:cd06663     2 ILIPDLAQHLGDGTVVKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVK-------EGTKVEGDTPLVKI 73
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 45-83 8.73e-07

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 43.17  E-value: 8.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEA 83
Cdd:cd06850    16 KEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKE 54
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 26-82 1.94e-05

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 42.50  E-value: 1.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2046543957  26 GITDFAQEELGAISGVNLPE----EGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHE 82
Cdd:PRK11855  118 GVVEVKVPDIGEITEVEVIEwlvkVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEIKVK 178
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 45-83 2.12e-05

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 39.70  E-value: 2.12e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEA 83
Cdd:cd06849    23 KEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEE 61
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 36-79 3.22e-05

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 41.99  E-value: 3.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2046543957   36 GAISGVNLpEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:COG1038   1085 GTVVKVLV-KEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEV 1127
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 45-79 5.18e-05

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 40.26  E-value: 5.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:COG0511    84 KVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEI 118
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 45-79 1.44e-04

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 37.74  E-value: 1.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:COG0508    25 KEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEI 59
PRK11856 PRK11856
branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed
 45-83 1.68e-04

branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed


Pssm-ID: 237001 [Multi-domain]  Cd Length: 411  Bit Score: 39.77  E-value: 1.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEA 83
Cdd:PRK11856   25 KVGDTVKEGQPLAEVETDKATVEIPSPVAGTVAKLLVEE 63
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 45-85 4.60e-04

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 38.58  E-value: 4.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2046543957   45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHEAVD 85
Cdd:PRK12999  1093 KEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGD 1133
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 46-79 6.81e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 37.88  E-value: 6.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2046543957  46 EGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:PRK11855   25 EGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEI 58
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 21-79 8.13e-04

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 37.93  E-value: 8.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2046543957  21 DAAVIGITDFAQEELGAISGVNLPE----EGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:TIGR01348 110 AGQSSGVQEVTVPDIGDIEKVTVIEvlvkVGDTVSADQSLITLESDKASMEVPAPASGVVKSV 172
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 45-79 9.96e-04

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 37.51  E-value: 9.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:PRK09282  539 KEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEI 573
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 47-79 1.12e-03

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 37.29  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2046543957  47 GDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:PRK11854  128 GDTVEAEQSLITVEGDKASMEVPAPFAGTVKEI 160
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 45-82 1.33e-03

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 35.27  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2046543957  45 EEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVNHE 82
Cdd:pfam00364  22 KVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVP 59
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 47-79 1.63e-03

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 36.90  E-value: 1.63e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2046543957  47 GDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAV 79
Cdd:PRK11854  229 GDKVEAEQSLITVEGDKASMEVPAPFAGTVKEI 261
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 43-77 4.94e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 35.30  E-value: 4.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2046543957  43 LPEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVR 77
Cdd:PRK14875   23 LVQEGDEVEKGDELLDVETDKITNEVEAPAAGTLR 57
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
36-80 5.26e-03

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 35.29  E-value: 5.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2046543957  36 GAISGVNLpEEGDEVEQDDSLGSVEARKTVSEIYAPFSGTVRAVN 80
Cdd:PRK14040  533 GNIFKVIV-TEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIA 576
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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