NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2035868906|ref|WP_211886194|]
View 

MULTISPECIES: winged helix-turn-helix domain-containing protein [unclassified Providencia]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10007860)

winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  10473770|8831795|15808743
SCOP:  3000034

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
1-108 5.10e-20

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


:

Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 82.26  E-value: 5.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035868906   1 MVYLINnDIEFIYERNVLYSRklNLEQSLLSPSSRILKYLIENNGCVITQSTLFQIGWEDKleYVTNNAFYQNISLLRKA 80
Cdd:COG3710     1 MRYRFG-DFRLDPARRELLRD--GEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGR--VVSDNSLTQAISRLRKA 75

                          90       100
                  ....*....|....*....|....*...
gi 2035868906  81 FEILNQKNKLIINFPKKGYSLDKNVIIE 108
Cdd:COG3710    76 LGDDGLEPRLIRTVPRRGYRLVAPVEVE 103
 
Name Accession Description Interval E-value
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
1-108 5.10e-20

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 82.26  E-value: 5.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035868906   1 MVYLINnDIEFIYERNVLYSRklNLEQSLLSPSSRILKYLIENNGCVITQSTLFQIGWEDKleYVTNNAFYQNISLLRKA 80
Cdd:COG3710     1 MRYRFG-DFRLDPARRELLRD--GEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGR--VVSDNSLTQAISRLRKA 75

                          90       100
                  ....*....|....*....|....*...
gi 2035868906  81 FEILNQKNKLIINFPKKGYSLDKNVIIE 108
Cdd:COG3710    76 LGDDGLEPRLIRTVPRRGYRLVAPVEVE 103
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 35-101 1.09e-08

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 51.01  E-value: 1.09e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2035868906   35 RILKYLIENNGCVITQSTLFQIGWEDKlEYVTNNAFYQNISLLRKAFEiLNQKNKLIINFPKKGYSL 101
Cdd:smart00862  12 RLLELLLRNPGRVVSREELLEAVWGDD-EDVDDNTLDVHISRLRKKLE-DDGDPRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
30-101 7.76e-07

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 45.58  E-value: 7.76e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2035868906  30 LSPS-SRILKYLIENNGCVITQSTLFQIGWEDKlEYVTNNAFYQNISLLRKAFEILNQKNKLIINFPKKGYSL 101
Cdd:pfam00486   6 LTPKeFKLLELLAENPGRVVSREQLLEEVWGED-YDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 30-101 3.43e-06

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 44.39  E-value: 3.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2035868906  30 LSPS-SRILKYLIENNGCVITQSTLFQIGWEDKlEYVTNNAFYQNISLLRKAFEILNQKNkLIINFPKKGYSL 101
Cdd:cd00383    19 LTPKeFELLELLARNPGRVVSREELLEAVWGYD-YEVDDRTVDVHISRLRKKLEDDPEPR-LIKTVRGVGYRL 89
 
Name Accession Description Interval E-value
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
1-108 5.10e-20

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 82.26  E-value: 5.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035868906   1 MVYLINnDIEFIYERNVLYSRklNLEQSLLSPSSRILKYLIENNGCVITQSTLFQIGWEDKleYVTNNAFYQNISLLRKA 80
Cdd:COG3710     1 MRYRFG-DFRLDPARRELLRD--GEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGR--VVSDNSLTQAISRLRKA 75

                          90       100
                  ....*....|....*....|....*...
gi 2035868906  81 FEILNQKNKLIINFPKKGYSLDKNVIIE 108
Cdd:COG3710    76 LGDDGLEPRLIRTVPRRGYRLVAPVEVE 103
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 35-101 1.09e-08

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 51.01  E-value: 1.09e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2035868906   35 RILKYLIENNGCVITQSTLFQIGWEDKlEYVTNNAFYQNISLLRKAFEiLNQKNKLIINFPKKGYSL 101
Cdd:smart00862  12 RLLELLLRNPGRVVSREELLEAVWGDD-EDVDDNTLDVHISRLRKKLE-DDGDPRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
30-101 7.76e-07

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 45.58  E-value: 7.76e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2035868906  30 LSPS-SRILKYLIENNGCVITQSTLFQIGWEDKlEYVTNNAFYQNISLLRKAFEILNQKNKLIINFPKKGYSL 101
Cdd:pfam00486   6 LTPKeFKLLELLAENPGRVVSREQLLEEVWGED-YDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 30-101 3.43e-06

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 44.39  E-value: 3.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2035868906  30 LSPS-SRILKYLIENNGCVITQSTLFQIGWEDKlEYVTNNAFYQNISLLRKAFEILNQKNkLIINFPKKGYSL 101
Cdd:cd00383    19 LTPKeFELLELLARNPGRVVSREELLEAVWGYD-YEVDDRTVDVHISRLRKKLEDDPEPR-LIKTVRGVGYRL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH