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Conserved domains on  [gi|1992667729|ref|WP_204387809|]
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MFS transporter [Bifidobacterium pullorum]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 2-421 1.01e-50

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 175.50  E-value: 1.01e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVALDAGSGLLVLAAASWFA 81
Cdd:cd06173     7 AQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  82 VqdGGFSIIAVGALMVSLSVLSAFETPTVQAALPQLLrgsGEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPLL 161
Cdd:cd06173    87 L--GSLSLWLLLVLAFLLGIASAFFGPARQALLPELV---PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 162 GVTIACFFCTAALECFIRLEPPHENEPREPIpptmdhahsdrptpqsdgtetspsgtargWISDIAAALRFLTheRPNIL 241
Cdd:cd06173   162 AINALSFLLSALLLLFIRRPPPAAPGESSSL-----------------------------LLRDLREGLRYLR--RSPLL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 242 RLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAVilpa 321
Cdd:cd06173   211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL---- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 322 gvgFLLPLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDTVAPE 401
Cdd:cd06173   287 ---ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363

                         410       420
                  ....*....|....*....|
gi 1992667729 402 WILVGTAAAILMLSAVSAPL 421
Cdd:cd06173   364 AVFLLAGALLLLAALLLLLL 383
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 2-421 1.01e-50

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 175.50  E-value: 1.01e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVALDAGSGLLVLAAASWFA 81
Cdd:cd06173     7 AQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  82 VqdGGFSIIAVGALMVSLSVLSAFETPTVQAALPQLLrgsGEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPLL 161
Cdd:cd06173    87 L--GSLSLWLLLVLAFLLGIASAFFGPARQALLPELV---PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 162 GVTIACFFCTAALECFIRLEPPHENEPREPIpptmdhahsdrptpqsdgtetspsgtargWISDIAAALRFLTheRPNIL 241
Cdd:cd06173   162 AINALSFLLSALLLLFIRRPPPAAPGESSSL-----------------------------LLRDLREGLRYLR--RSPLL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 242 RLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAVilpa 321
Cdd:cd06173   211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL---- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 322 gvgFLLPLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDTVAPE 401
Cdd:cd06173   287 ---ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363

                         410       420
                  ....*....|....*....|
gi 1992667729 402 WILVGTAAAILMLSAVSAPL 421
Cdd:cd06173   364 AVFLLAGALLLLAALLLLLL 383
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-399 1.76e-30

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 120.50  E-value: 1.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVALDAGSGllVLAAASWFA 81
Cdd:TIGR00900   7 AQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRA--VLVAVLPFV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  82 VQDGGFSIIAVGALMVSLSVLSAFETPTVQAALPQLLRgsgEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPLL 161
Cdd:TIGR00900  85 ALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVP---EEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 162 GVTIACFFCTAALECFIRLEPPhENEPREPIPPtmdhahsdrptpqsdgtetspsgtarGWISDIAAALRFLTHERPnIL 241
Cdd:TIGR00900 162 WVDAVGFAISALLIVSVRIPEL-AASEIQALSN--------------------------AVLRDTREGIKFVLKNPL-LR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 242 RLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMPAAMTVLGAVILPA 321
Cdd:TIGR00900 214 TLLLLALLFNLVFAPAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLG-----RYFKRMALMTGAIFVIG 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1992667729 322 GVGFLLPLGNmAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDTVA 399
Cdd:TIGR00900 289 LAILVVGLTP-PNFPLFLVLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 5-418 2.48e-13

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 71.70  E-value: 2.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   5 LSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagsGLLVLAAASWFAVQD 84
Cdd:pfam05977  21 ASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLA-----GQLLLALVSTLLTLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  85 GGFSIIAVGALMVSLSVLS---AFETPTVQAALPQLL--RGSGEAVIRRGMAVinqvqQLSSLLPSFIGGALYGLIGIGP 159
Cdd:pfam05977  96 AGLGLLSPWLLLGLTFLGGigtALMDPAWQASVPELVprRDLPAAVALNSVGY-----NIARSVGPALGGVLLAAFGPAF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 160 LLGVTIACFFCTAALECFIRLEPPHENEPREPIpptmdhahsdrptpqsdgtetspsGTArgwisdIAAALRFLTHERPn 239
Cdd:pfam05977 171 TFALNALSYFAVIAALWRWKRAAPASPLPRERI------------------------FGA------VRAGLRFTAMSRE- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 240 iLRLMLLASVInlFAVGYSAVG--FPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAV 317
Cdd:pfam05977 220 -LRSVLVRAFA--FGLSASAVWalLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTAL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 318 ILpAGVGFLLPLGnMAKLIALVSSCCLVGFACSFTNiiaipAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDT 397
Cdd:pfam05977 297 VL-LSLALAPNLW-LAIPVLLLGGAAWITALTTLNV-----AVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEA 369

                         410       420
                  ....*....|....*....|.
gi 1992667729 398 VAPEWILVGTAAAILMLSAVS 418
Cdd:pfam05977 370 LSVTGALLGAAAALLAGAAAG 390
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
4-421 7.62e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 63.77  E-value: 7.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   4 GLSLFGSMMLRFAMSMWVL----DETG-SATVFASVLAAAIVPTILLSPFGGVLADRVN-----RRTIMVALDAGSGLLV 73
Cdd:COG2211    16 GLGDLGLNLAFGLLSAYLLyfytDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  74 LAAASWFAVQDGGFSIIAVGALMVSLSVLSAFETPtVQAALPQLLRGSGEAVirRGMAVINQVQQLSSLLPSFIGGALYG 153
Cdd:COG2211    96 VLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIP-YSALGAELTPDYEERT--RLSSWRFAFAGLGGLLASVLPPPLVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 154 LIGIGPLLGVTI-----ACFFCTAALECFIRLepphenepREPIPPTMDHahsdrptpqsdgtetspsgtargwiSDIAA 228
Cdd:COG2211   173 AFGGDAALGYRLtalifAVLGLLAFLLTFFGT--------KERPVPEEEK-------------------------VSLKE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 229 ALRFLTHERPniLRLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMP 308
Cdd:COG2211   220 SLKALLKNRP--FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA-----KRFG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 309 AAMTVLGAVILPAGVGFLLPLGNMAKLIALVSSCCLVGFACSFTNII-------AIPAIQIRTPETMTGKVMSLLASFAT 381
Cdd:COG2211   293 KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLpwamladVVDYDEWKTGRRREGLYFGIFTFAIK 372

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1992667729 382 CTQPLGQMLYGWLYDTVAPEWILVGTAAAILMLSAVSAPL 421
Cdd:COG2211   373 LGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
PRK10489 PRK10489
enterobactin transporter EntS;
5-421 4.28e-09

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 58.07  E-value: 4.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   5 LSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRR-TIMVALD-AGSGLLVLAAASWF-- 80
Cdd:PRK10489   28 ISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKkLILLARGtCGLGFIGLALNAFLpe 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  81 ---------AVQDGGFSIIAVGALMvslsvlsafetptvqAALPQLlrgsgeaVIRRGMAVINQVQQLSSLLPSFIGGAL 151
Cdd:PRK10489  108 psllaiyllGLWDGFFGSLGVTALL---------------AATPAL-------VGRENLMQAGAITMLTVRLGSVISPAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 152 YGLI----GIGPLLGVTIACFFCTaaLECFIRLepphenePREPiPPTMDHAHSDRptpqsdgtetspsgtargwisDIA 227
Cdd:PRK10489  166 GGLLiaagGVAWNYGLAAAGTFIT--LLPLLRL-------PALP-PPPQPREHPLR---------------------SLL 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 228 AALRFLTHERpnILRLMLLASVINLFAVGYsAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATAltidRM 307
Cdd:PRK10489  215 AGFRFLLASP--VVGGIALLGGLLTMASAV-RVLYPALADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHS----AR 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 308 PAAMTVLGAVILPAGVGFllpLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLG 387
Cdd:PRK10489  288 PGLLMLLSTLGSFLAVGL---FGLMPMWILAVLCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIG 364

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1992667729 388 QMLYGWLYDTVAPE----WILVGTAAAILMLSAVSAPL 421
Cdd:PRK10489  365 AALLGGLGAMMTPVasasASGFGLLIIGVLLLLVLGEL 402
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 2-421 1.01e-50

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 175.50  E-value: 1.01e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVALDAGSGLLVLAAASWFA 81
Cdd:cd06173     7 AQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  82 VqdGGFSIIAVGALMVSLSVLSAFETPTVQAALPQLLrgsGEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPLL 161
Cdd:cd06173    87 L--GSLSLWLLLVLAFLLGIASAFFGPARQALLPELV---PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 162 GVTIACFFCTAALECFIRLEPPHENEPREPIpptmdhahsdrptpqsdgtetspsgtargWISDIAAALRFLTheRPNIL 241
Cdd:cd06173   162 AINALSFLLSALLLLFIRRPPPAAPGESSSL-----------------------------LLRDLREGLRYLR--RSPLL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 242 RLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAVilpa 321
Cdd:cd06173   211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL---- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 322 gvgFLLPLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDTVAPE 401
Cdd:cd06173   287 ---ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363

                         410       420
                  ....*....|....*....|
gi 1992667729 402 WILVGTAAAILMLSAVSAPL 421
Cdd:cd06173   364 AVFLLAGALLLLAALLLLLL 383
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-399 1.76e-30

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 120.50  E-value: 1.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVALDAGSGllVLAAASWFA 81
Cdd:TIGR00900   7 AQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRA--VLVAVLPFV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  82 VQDGGFSIIAVGALMVSLSVLSAFETPTVQAALPQLLRgsgEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPLL 161
Cdd:TIGR00900  85 ALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVP---EEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 162 GVTIACFFCTAALECFIRLEPPhENEPREPIPPtmdhahsdrptpqsdgtetspsgtarGWISDIAAALRFLTHERPnIL 241
Cdd:TIGR00900 162 WVDAVGFAISALLIVSVRIPEL-AASEIQALSN--------------------------AVLRDTREGIKFVLKNPL-LR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 242 RLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMPAAMTVLGAVILPA 321
Cdd:TIGR00900 214 TLLLLALLFNLVFAPAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLG-----RYFKRMALMTGAIFVIG 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1992667729 322 GVGFLLPLGNmAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDTVA 399
Cdd:TIGR00900 289 LAILVVGLTP-PNFPLFLVLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 5-418 2.48e-13

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 71.70  E-value: 2.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   5 LSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagsGLLVLAAASWFAVQD 84
Cdd:pfam05977  21 ASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLA-----GQLLLALVSTLLTLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  85 GGFSIIAVGALMVSLSVLS---AFETPTVQAALPQLL--RGSGEAVIRRGMAVinqvqQLSSLLPSFIGGALYGLIGIGP 159
Cdd:pfam05977  96 AGLGLLSPWLLLGLTFLGGigtALMDPAWQASVPELVprRDLPAAVALNSVGY-----NIARSVGPALGGVLLAAFGPAF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 160 LLGVTIACFFCTAALECFIRLEPPHENEPREPIpptmdhahsdrptpqsdgtetspsGTArgwisdIAAALRFLTHERPn 239
Cdd:pfam05977 171 TFALNALSYFAVIAALWRWKRAAPASPLPRERI------------------------FGA------VRAGLRFTAMSRE- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 240 iLRLMLLASVInlFAVGYSAVG--FPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAV 317
Cdd:pfam05977 220 -LRSVLVRAFA--FGLSASAVWalLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTAL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 318 ILpAGVGFLLPLGnMAKLIALVSSCCLVGFACSFTNiiaipAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDT 397
Cdd:pfam05977 297 VL-LSLALAPNLW-LAIPVLLLGGAAWITALTTLNV-----AVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEA 369

                         410       420
                  ....*....|....*....|.
gi 1992667729 398 VAPEWILVGTAAAILMLSAVS 418
Cdd:pfam05977 370 LSVTGALLGAAAALLAGAAAG 390
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
4-421 7.62e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 63.77  E-value: 7.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   4 GLSLFGSMMLRFAMSMWVL----DETG-SATVFASVLAAAIVPTILLSPFGGVLADRVN-----RRTIMVALDAGSGLLV 73
Cdd:COG2211    16 GLGDLGLNLAFGLLSAYLLyfytDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  74 LAAASWFAVQDGGFSIIAVGALMVSLSVLSAFETPtVQAALPQLLRGSGEAVirRGMAVINQVQQLSSLLPSFIGGALYG 153
Cdd:COG2211    96 VLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIP-YSALGAELTPDYEERT--RLSSWRFAFAGLGGLLASVLPPPLVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 154 LIGIGPLLGVTI-----ACFFCTAALECFIRLepphenepREPIPPTMDHahsdrptpqsdgtetspsgtargwiSDIAA 228
Cdd:COG2211   173 AFGGDAALGYRLtalifAVLGLLAFLLTFFGT--------KERPVPEEEK-------------------------VSLKE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 229 ALRFLTHERPniLRLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMP 308
Cdd:COG2211   220 SLKALLKNRP--FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA-----KRFG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 309 AAMTVLGAVILPAGVGFLLPLGNMAKLIALVSSCCLVGFACSFTNII-------AIPAIQIRTPETMTGKVMSLLASFAT 381
Cdd:COG2211   293 KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLpwamladVVDYDEWKTGRRREGLYFGIFTFAIK 372

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1992667729 382 CTQPLGQMLYGWLYDTVAPEWILVGTAAAILMLSAVSAPL 421
Cdd:COG2211   373 LGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 34-419 8.13e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.36  E-value: 8.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  34 VLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagsGLLVLAAASWFAVQDGGFSIIAVGALMVSLSvlSAFETPTVQAA 113
Cdd:cd17325    36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLL-----GLLLLAVSTLLFAFATSYWQLLLARFLQGLA--SAAVWPAAMAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 114 LPQLlrgSGEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPLLGVTIACFFCTAALeCFIRLEPPHENEPREPIP 193
Cdd:cd17325   109 IADI---APPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL-ALLLLPEPRPPPNKRAVS 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 194 PtmdhahsdrptpqsdgtetspsgtargwiSDIAAALRFLTHERPniLRLMLLASVINLFAVGYSAVGFPFMIRTVLGFD 273
Cdd:cd17325   185 A-----------------------------ARLRSGLRLLLRDRR--LLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 274 AAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMPAAMTVLGAVILPAGVGFLLPLgnMAKLIALVSSCCLVGFACSFTN 353
Cdd:cd17325   234 PAQIGLLFGAQGLASALSQPPAGKLS-----DRIGRKPLILIGLLLSAVALLLLPL--ATSFWLLLLLLALLGLGLGLVF 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1992667729 354 IIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDTVAPEWILVGTAAAILMLSAVSA 419
Cdd:cd17325   307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-379 2.55e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.53  E-value: 2.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   1 MGQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagsGLLVLAAASWF 80
Cdd:COG2814    17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL-----GLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  81 AVQDGGFSIIAVGALMVSLSvlSAFETPTVQAALPQLLRGSGEAvirRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPL 160
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLG--AGALFPAALALIADLVPPERRG---RALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 161 LGVTIACFFCTAALecFIRLEPPHENEPREPIPPTMDHAHSDRptpqsdgtetspsgtargwisdiaaalrfltherpnI 240
Cdd:COG2814   167 FLVNAVLALLALLL--LLRLLPESRPAARARLRGSLRELLRRP------------------------------------R 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 241 LRLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMPAAMTVLGAVILp 320
Cdd:COG2814   209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA-----DRFGRRRLLLIGLLL- 282

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1992667729 321 AGVGFLLpLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASF 379
Cdd:COG2814   283 LALGLLL-LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
PRK10489 PRK10489
enterobactin transporter EntS;
5-421 4.28e-09

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 58.07  E-value: 4.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   5 LSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRR-TIMVALD-AGSGLLVLAAASWF-- 80
Cdd:PRK10489   28 ISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKkLILLARGtCGLGFIGLALNAFLpe 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  81 ---------AVQDGGFSIIAVGALMvslsvlsafetptvqAALPQLlrgsgeaVIRRGMAVINQVQQLSSLLPSFIGGAL 151
Cdd:PRK10489  108 psllaiyllGLWDGFFGSLGVTALL---------------AATPAL-------VGRENLMQAGAITMLTVRLGSVISPAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 152 YGLI----GIGPLLGVTIACFFCTaaLECFIRLepphenePREPiPPTMDHAHSDRptpqsdgtetspsgtargwisDIA 227
Cdd:PRK10489  166 GGLLiaagGVAWNYGLAAAGTFIT--LLPLLRL-------PALP-PPPQPREHPLR---------------------SLL 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 228 AALRFLTHERpnILRLMLLASVINLFAVGYsAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATAltidRM 307
Cdd:PRK10489  215 AGFRFLLASP--VVGGIALLGGLLTMASAV-RVLYPALADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHS----AR 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 308 PAAMTVLGAVILPAGVGFllpLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLG 387
Cdd:PRK10489  288 PGLLMLLSTLGSFLAVGL---FGLMPMWILAVLCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIG 364

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1992667729 388 QMLYGWLYDTVAPE----WILVGTAAAILMLSAVSAPL 421
Cdd:PRK10489  365 AALLGGLGAMMTPVasasASGFGLLIIGVLLLLVLGEL 402
MFS_1 pfam07690
Major Facilitator Superfamily;
2-379 6.41e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.88  E-value: 6.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETG-SATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagsGLLVLAAASWF 80
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI-----GLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  81 AVQDGGFSIIAVGALMvsLSVLSAFETPTVQAALPQLLRGSGEAvirRGMAVINQVQQLSSLLPSFIGGALYGLIGIgPL 160
Cdd:pfam07690  79 LLFASSLWLLLVLRVL--QGLGAGALFPAALALIADWFPPEERG---RALGLVSAGFGLGAALGPLLGGLLASLFGW-RA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 161 LGVTIACFFCTAALECFIRLEPPheneprepipptmdhahsdrptpqsdgtETSPSGTARGWISDIAAALRFLTHERPni 240
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPP----------------------------ESKRPKPAEEARLSLIVAWKALLRDPV-- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 241 lrLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIdRMPAAMTVLGAVILP 320
Cdd:pfam07690 203 --LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR-RRRLLLALLLLILAA 279

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1992667729 321 AGVGFLLPLGNMAKLIALvssCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASF 379
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLA---LLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-398 9.03e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 9.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   1 MGQGLSLFGSMMLRFAMSMWVLDETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagSGLLVLAAASWF 80
Cdd:cd06174     3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLL----GLLLFALGALLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  81 AVqdggfsIIAVGALMVSLSVLSAFETPTVQAALPQLLRGSGEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIG-- 158
Cdd:cd06174    79 AF------APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwr 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 159 -PLLGVTIACFFCTAALECFIRLEPPHENEPREPIPPTMDHAHsdrptpqsdgtetspsgtargwisdiaaalrFLTHER 237
Cdd:cd06174   153 aVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------------------------------LKRVLK 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 238 PNILRLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAV 317
Cdd:cd06174   202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 318 ILPAGVGFLLPlgnmakLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDT 397
Cdd:cd06174   282 LGLALLLLAPS------LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355


                  .
gi 1992667729 398 V 398
Cdd:cd06174   356 T 356
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
240-423 3.90e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.71  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 240 ILRLMLLASVINLFAVGYSAVGF--PFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMPAAMTVLGAV 317
Cdd:COG2271   179 LLRFWLLALAYFLVYFALYGFLTwlPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLS-----DRLGRRRKLVLAI 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 318 ILPAGVGFLLPLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYGWLYDT 397
Cdd:COG2271   254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333

                         170       180
                  ....*....|....*....|....*.
gi 1992667729 398 VAPEWILVgTAAAILMLSAVSAPLFA 423
Cdd:COG2271   334 TGYQAAFL-LLAALALLAALLALLLL 358
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 23-374 5.32e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 48.77  E-value: 5.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   23 DETGSATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVALDAGSGLLVLAAASWFAVQDGGFSIIAVgALMvslSVL 102
Cdd:PRK08633    41 DGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFAVT-FLL---GAQ 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  103 SAFETPTVQAALPQLLRgsgeaviRRGMAVINQVQQLSSLLPSFIGGALYGLI--------------GIGPLLGVTIACf 168
Cdd:PRK08633   117 SAIYSPAKYGIIPELVG-------KENLSRANGLLEAFTIVAILAGTALFSFLfesvngntpseilgRIAPAGLVLLAV- 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  169 fctAALECFIrleppheneprepipptmdhAHSDRPTPQSDGTETSPSGTARGwiSDIAAALRFLTHERpNILRLMLLAS 248
Cdd:PRK08633   189 ---AVLGLIF--------------------AYRLPKVPAAAPEVFDKKKYLFP--KLLWRNLKLLRSDR-VLWLAIIGLS 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  249 VINLFAVGYSAVgFPFMIRTVLGFDAAVYGicdGIIGIAAVIGAILAGLLATALTIDRMPAAMTVLGAVilpaGVG-FLL 327
Cdd:PRK08633   243 YFWFISQLAQAN-FPAYAKEVLGLDNTFQV---QYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGAL----GLAlSLF 314

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1992667729  328 PLGNMAKLIALVSSCCLVGFacsFTNIIAIPA---IQIRTPETMTGKVMS 374
Cdd:PRK08633   315 LLPTAPSLASVLVLFFLFGF---SAGLFIVPLnalIQFRAPEKELGKVLA 361
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 2-417 7.17e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   2 GQGLSLFGSMMLRFAMSMWVLDETG-SATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldagsGLLVLAAASWF 80
Cdd:cd17329     7 GSFLNRLGFFMVWPFMAIYLHQQLGlSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLA-----GLLLRALGFAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  81 AVQDGGFSIIAVGALMVSLSvlSAFETPTVQAALPQLLRGSGEaviRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGPL 160
Cdd:cd17329    82 LGFAHSPWLFAIALVLTGFG--GGLFEPASEAMIADVTTPENR---TRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 161 LGVTIACFFCTAaleCFIRLEPPHENEPREPIPPtmdhahsdrptpqsdgtetspsgtargwisDIAAALRFLTHERPni 240
Cdd:cd17329   157 LAAAVLFLLAAL---VLLFLLPETRPKRRAAEKT------------------------------EILRGYKIVLRDRA-- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 241 LRLMLLASVINLFAVGYSAVGFPFMIRTVLGFDAAVYGIcdgIIGIAAVIgAILAGLLATALTIDRMPAAMTVLGAVILP 320
Cdd:cd17329   202 FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGL---LLALNALL-IVLLQFPVARLVERFRLRKILMIGILLFA 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 321 AGVGFLLPLGNMAKLIALVsscclvgFACSFTNIIAIPAIQI----RTPETMTGKVMSLLASFATCTQPLGQMLYGWLYD 396
Cdd:cd17329   278 IGFAVLAFANTLAVLILAM-------IVLTLGEMLVFPAVQTlvaaLAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD 350

                         410       420
                  ....*....|....*....|....*.
gi 1992667729 397 TVAPEW-----ILVGTAAAILMLSAV 417
Cdd:cd17329   351 LLGPGLpwlilAALGLIAAALLLGLQ 376
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 212-417 7.10e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.41  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 212 ETSPSGTARGWISDIAAALRFLTHERPNILRLMLLASVINLFAVGYSAVgfPFMIRTVLGFDAAVYGICDGIIGIAAVIG 291
Cdd:cd17320   176 ETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAA--PFIYIEQLGLSPAQFGLLFALNAIALILG 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 292 AILAGLLATALTIDRMpaAMTVLGAVILPAGVGFLLPLGNMAKLIALVSSCCLVGFACSFTNIIAIpAIQIRTPETMTGK 371
Cdd:cd17320   254 SLLNGRLVRRFGPRRL--LRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNAT-SLALEPFPHVAGT 330

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1992667729 372 VMSLLASFATCTQPLGQMLYGWLYDTVAPEWILVGTAAAILMLSAV 417
Cdd:cd17320   331 ASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLL 376
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
3-319 1.03e-03

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 41.49  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729    3 QGLSLFGSMMLRFAMSM---WVLDETGSATVFASVLAAA---IVPTILLSPFGGVLADRVNRRTIMVALDAgSGLLVLAA 76
Cdd:PRK06814    20 QFFGAFNDNFLKNALVIlilYGLSGALGAYNNALVTLAGavfILPFFIFSALAGQLADKYDKAKLAKILKF-AEIGIAAL 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   77 ASWfavqdgGFSIIAVGALMVSL---SVLSAFETPTVQAALPQLLR----GSGEAVIRRGMAVinqvqqlsSLLPSFIGG 149
Cdd:PRK06814    99 AIY------GFHLNSVPLLFAALflmGIHSALFGPIKYSILPDHLNkdelLGANALVEAGTFI--------AILLGTIIG 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  150 ALY-----GLIGIGPLLGVTIACFFCTAAlecfirleppheneprepIPPTMDHAHSDRPTpqsdgtetspsgtaRGWIS 224
Cdd:PRK06814   165 GLAtisgnFVILVALLMGIAVLGWLASLF------------------IPKTGNAAPDLKID--------------RNIIR 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  225 DIAAALRFLtHERPNILRLMLLASVINLF-AVGYSAvgFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAilagLLATALT 303
Cdd:PRK06814   213 STITLLKYA-KADKRIWLAILGISWFWLVgAVVLSQ--LPLLAKETLGGDENVATLFLAVFSVGVAVGS----FLASKLS 285

                          330
                   ....*....|....*.
gi 1992667729  304 IDRMPAAMTVLGAVIL 319
Cdd:PRK06814   286 EGRITLLYVPIGALLM 301
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 23-174 1.68e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  23 DETGSATVFASVLAAAIVPTILLSPFGGVLADRV-NRRTIMVALDAGSGLLVLAAASWFAVQDGGFSI---IAVGALMVS 98
Cdd:cd17391   234 DASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIgHHRILLGALLASALLYIPQAFVQTPWQLGILRFllgLATGGLLPA 313

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1992667729  99 LSVLSAFETPtvqaalpqllrgsgEAVIRRGMAVINQVQQLSSLLPSFIGGALYGLIGIGpllgvtiACFFCTAAL 174
Cdd:cd17391   314 INSLLAKITP--------------KEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYR-------AVFVVTALL 368
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
4-397 7.94e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.32  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729   4 GLSLFGSMMLRFAMSMWVL---DETG-SATVFASVLAAAIVPTILLSPFGGVLADRVNRRTIMVAldAGSGLLVLAAASW 79
Cdd:COG2223    11 TLAFFLAFGVWYLWSVLAPplaEEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI--GLLLLGIGLLLLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729  80 FAVQDGGFSIIAV-------GALMVSLSVLSAFETPTVQAALPQLLRGSGeavirrgmavinqvqQLSSLLPSFIGGALY 152
Cdd:COG2223    89 LAVSYWLLLLLGLllgigggGSFAVGIALVSKWFPPDRRGLALGLAAGGG---------------NLGAAVAAFLAPLLI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 153 GLIGIGPLLGVTIACFFCTAALECFIRLEPPHENEPREPIPptmdhahsdrptpqsdgtetspsgtargwISDIAAALRf 232
Cdd:COG2223   154 AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------------------------LRDQLEALR- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 233 ltheRPNILRLMLLASVINLFAVGYSAVgFPFMIRTVLGFDAAVYGICDGIIGIAAVIGAILAGLLAtaltiDRMPAAMT 312
Cdd:COG2223   204 ----DPRFWLLSLLYFGTFGSFIGFSSW-LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLS-----DRIGGRRV 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992667729 313 VLGAVILpAGVGFLLPLGNMAKLIALVSSCCLVGFACSFTNIIAIPAIQIRTPETMTGKVMSLLASFATCTQPLGQMLYG 392
Cdd:COG2223   274 LLIVFAL-MALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352


                  ....*
gi 1992667729 393 WLYDT 397
Cdd:COG2223   353 ALLDA 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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