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Conserved domains on  [gi|1944392198|ref|WP_197769330|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Serratia]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-103 1.34e-31

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 109.19  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944392198   2 KAKGFEGMTCSVAHVLSALGDRWGAILMRDLLLGLSRYDDLRQST-GITNNTLTDRLKALENHGLIEKRQYQTRPDRYEY 80
Cdd:COG1733     1 KKKDLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEY 80

                          90       100
                  ....*....|....*....|...
gi 1944392198  81 LPTEKGKDLGLLVMAMIQIGDKW 103
Cdd:COG1733    81 SLTEKGRSLLPVLDALAEWGEEH 103
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-103 1.34e-31

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 109.19  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944392198   2 KAKGFEGMTCSVAHVLSALGDRWGAILMRDLLLGLSRYDDLRQST-GITNNTLTDRLKALENHGLIEKRQYQTRPDRYEY 80
Cdd:COG1733     1 KKKDLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEY 80

                          90       100
                  ....*....|....*....|...
gi 1944392198  81 LPTEKGKDLGLLVMAMIQIGDKW 103
Cdd:COG1733    81 SLTEKGRSLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 20-103 8.86e-16

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 68.48  E-value: 8.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944392198  20 LGDRWGAILMRDLLLGLSRYDDLRQS-TGITNNTLTDRLKALENHGLIEKRQYQTRPDRYEYLPTEKGKDLGLLVMAMIQ 98
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAiPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*
gi 1944392198  99 IGDKW 103
Cdd:pfam01638  82 WGEEY 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-70 9.32e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.43  E-value: 9.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1944392198  17 LSALGDRWGAILMRDLLLGLSRYDDLRQSTGITNNTLTDRLKALENHGLIEKRQ 70
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-103 1.34e-31

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 109.19  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944392198   2 KAKGFEGMTCSVAHVLSALGDRWGAILMRDLLLGLSRYDDLRQST-GITNNTLTDRLKALENHGLIEKRQYQTRPDRYEY 80
Cdd:COG1733     1 KKKDLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEY 80

                          90       100
                  ....*....|....*....|...
gi 1944392198  81 LPTEKGKDLGLLVMAMIQIGDKW 103
Cdd:COG1733    81 SLTEKGRSLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 20-103 8.86e-16

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 68.48  E-value: 8.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944392198  20 LGDRWGAILMRDLLLGLSRYDDLRQS-TGITNNTLTDRLKALENHGLIEKRQYQTRPDRYEYLPTEKGKDLGLLVMAMIQ 98
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAiPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*
gi 1944392198  99 IGDKW 103
Cdd:pfam01638  82 WGEEY 86
B-block_TFIIIC pfam04182
B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit ...
 26-76 8.75e-05

B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding.


Pssm-ID: 367858  Cd Length: 75  Bit Score: 39.16  E-value: 8.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1944392198  26 AILMRdllLGLSRYD-----DLRQSTGITNNTLTDRLKALENHGLIEKRQYQTRPD 76
Cdd:pfam04182   6 CLLEE---IARSRYNgitqsDLAKLTGQDPRSLHYRLKKLEKKGLIVKQQIIQSNT 58
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-70 9.32e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.43  E-value: 9.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1944392198  17 LSALGDRWGAILMRDLLLGLSRYDDLRQSTGITNNTLTDRLKALENHGLIEKRQ 70
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
30-96 9.97e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 35.25  E-value: 9.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1944392198  30 RDLLLGLS----RYDDLRQSTGITNNTLTDRLKALENHGLIEKRQyqtrpDRYEylPTEKGKdlgLLVMAM 96
Cdd:COG4742    19 KNILLLLAegpkTRSELAESLDVSRSTILRQLKELEERGLIERDD-----GEYE--LTTLGR---LVVEEM 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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