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Conserved domains on  [gi|1918169079|ref|WP_192970987|]
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MULTISPECIES: methyl-accepting chemotaxis protein [unclassified Enterobacter cloacae complex]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1003728)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 1-553 0e+00

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15041:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 554  Bit Score: 554.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  81 PASLAAINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15041   81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 161 DDMEAVYNRWRAENNTLLKAATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQD 240
Cdd:PRK15041  161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNS 320
Cdd:PRK15041  241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 321 DNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041  321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15041  401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1918169079 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNG---KANATAPRPADVKTPQLLRPATANATpdSNWETF 553
Cdd:PRK15041  481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQqqqQQRETSAVVKTVTPATPRKMAVADSG--ENWETF 554
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-553 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 554.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  81 PASLAAINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15041   81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 161 DDMEAVYNRWRAENNTLLKAATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQD 240
Cdd:PRK15041  161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNS 320
Cdd:PRK15041  241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 321 DNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041  321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15041  401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1918169079 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNG---KANATAPRPADVKTPQLLRPATANATpdSNWETF 553
Cdd:PRK15041  481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQqqqQQRETSAVVKTVTPATPRKMAVADSG--ENWETF 554
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
20-517 4.15e-99

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 310.41  E-value: 4.15e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  20 LLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASLAAINKLLGTAGDSLA 99
Cdd:COG0840     8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 100 KAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLK 179
Cdd:COG0840    88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 180 AATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEM 259
Cdd:COG0840   168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 260 QQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAAR 339
Cdd:COG0840   248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 340 GGHVVDNVVR--------------TMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRT 405
Cdd:COG0840   328 GGEVVEEAVEgieeiresveetaeTIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 406 LASRSAQAAKEIKGLIENSVSRVNT--------------GSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIE 471
Cdd:COG0840   408 LAERSAEATKEIEELIEEIQSETEEaveameegseeveeGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1918169079 472 QVSLAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRL 517
Cdd:COG0840   488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 269-516 1.08e-71

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 229.87  E-value: 1.08e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  269 AVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVV 348
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  349 RTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIEN----- 423
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  424 ---------SVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQS 494
Cdd:smart00283 161 neavaameeSSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 1918169079  495 ATAAAALEDQSEQLRQAVAAFR 516
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 296-495 2.49e-61

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 200.93  E-value: 2.49e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 296 EEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQT 375
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 376 NILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDI 455
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1918169079 456 MGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQSA 495
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 329-484 4.42e-60

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 196.50  E-value: 4.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 329 LAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAS 408
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 409 RSAQAAKEIKGLI--------------ENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVS 474
Cdd:pfam00015  83 RSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162

                         170
                  ....*....|
gi 1918169079 475 LAVSQMDSVT 484
Cdd:pfam00015 163 QAVARMDQVT 172
antiphage_ZorA_1 NF033914
anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel ...
 248-514 3.37e-07

anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.


Pssm-ID: 411475 [Multi-domain]  Cd Length: 619  Bit Score: 53.07  E-value: 3.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 248 EMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLsarTEEQASSLEETA----ASMEELTATVKQNSD-- 321
Cdd:NF033914  291 ELRELAETLKQMQGSLVEMQGGLRGSGEDFARRMSEAAENLNRL---VSDAGSSLGDSAeqsrDALAEVVAALRQTFEka 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 322 NARQATLLAKNASETAARgghVVDNVVRTMNEIadsSQQIAHITGviDSIAFQTNilaLNAAVEAARAGEQgrgfAVVAG 401
Cdd:NF033914  368 NAEVDEALGAAAGGASGK---LEEAMGRVLEKL---EAQIGGLGE--GLGAFQGT---LAEQLDETREQIA----AAQQS 432

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 402 EVRTLASRSAQAAKEIKGLIENSVSRVNtgsEQVSEAGATMKEIVAAVTRVTDIMGEISSasdeQSRgieQVSLAVSQM- 480
Cdd:NF033914  433 AAAAVASASAEAAEALRDGLADALATIR---AEIDRFEAAMRASEGALASQANAIGDATS----QTR---KVADAFSKTa 502

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1918169079 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAA 514
Cdd:NF033914  503 QDVRAAAAPLAQSGERIAGATESMAESVGRTVEA 536
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-553 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 554.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  81 PASLAAINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15041   81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 161 DDMEAVYNRWRAENNTLLKAATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQD 240
Cdd:PRK15041  161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNS 320
Cdd:PRK15041  241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 321 DNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041  321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15041  401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1918169079 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNG---KANATAPRPADVKTPQLLRPATANATpdSNWETF 553
Cdd:PRK15041  481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQqqqQQRETSAVVKTVTPATPRKMAVADSG--ENWETF 554
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-553 0e+00

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 541.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15048    1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  81 PASlAAINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEMQKsWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15048   81 QQS-NAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEK-YKNYYTALTELIDYLDYGNTGAYFAQPTQGMQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 161 DDMEAVYNRWRAENNTLLKAATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQD 240
Cdd:PRK15048  159 NAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNS 320
Cdd:PRK15048  239 LTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 321 DNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15048  319 DNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15048  399 GEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEM 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLngkanatAPRPADVKTPQLLRPATA---------NATPDSNWE 551
Cdd:PRK15048  479 DRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRL-------AASPLTNKPQTPSRPASEqppaqprlrIAEQDPNWE 551


                  ..
gi 1918169079 552 TF 553
Cdd:PRK15048  552 TF 553
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
1-517 8.12e-137

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 407.54  E-value: 8.12e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTV----TRVAIRYLK 76
Cdd:PRK09793    1 MFNRIRISTTLFLILILCGILQIGSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALnkagTLTALSYPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  77 NQrdpaslaaINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDA 156
Cdd:PRK09793   81 DD--------IKTLMTTARASLTQSTTLFKSFMAMTAGNEHVRALQKETEKSFARWHNDLEHQATWLESNQLSDFLTAPV 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 157 QQAQDDMEAVYNRWRAENNTLLKAATEENQSSFtQMQWTLAAIFLAVIAVLV---VIWQglQHLLLKPLNAIMNHIRAIA 233
Cdd:PRK09793  153 QGSQNAFDVNFEAWQLEINHVLEAASAQSQRNY-QISALVFISMIIVAAIYIssaLWWT--RKMIVQPLAIIGSHFDSIA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 234 GGDLTQDITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELT 313
Cdd:PRK09793  230 AGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLT 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 314 ATVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQG 393
Cdd:PRK09793  310 ATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQG 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 394 RGFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQV 473
Cdd:PRK09793  390 RGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQV 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1918169079 474 SLAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRL 517
Cdd:PRK09793  470 AQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
20-517 4.15e-99

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 310.41  E-value: 4.15e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  20 LLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASLAAINKLLGTAGDSLA 99
Cdd:COG0840     8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 100 KAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLK 179
Cdd:COG0840    88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 180 AATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEM 259
Cdd:COG0840   168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 260 QQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAAR 339
Cdd:COG0840   248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 340 GGHVVDNVVR--------------TMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRT 405
Cdd:COG0840   328 GGEVVEEAVEgieeiresveetaeTIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 406 LASRSAQAAKEIKGLIENSVSRVNT--------------GSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIE 471
Cdd:COG0840   408 LAERSAEATKEIEELIEEIQSETEEaveameegseeveeGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1918169079 472 QVSLAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRL 517
Cdd:COG0840   488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 269-516 1.08e-71

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 229.87  E-value: 1.08e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  269 AVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVV 348
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  349 RTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIEN----- 423
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  424 ---------SVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQS 494
Cdd:smart00283 161 neavaameeSSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 1918169079  495 ATAAAALEDQSEQLRQAVAAFR 516
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 296-495 2.49e-61

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 200.93  E-value: 2.49e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 296 EEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQT 375
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 376 NILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDI 455
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1918169079 456 MGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQSA 495
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 329-484 4.42e-60

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 196.50  E-value: 4.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 329 LAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAS 408
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 409 RSAQAAKEIKGLI--------------ENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVS 474
Cdd:pfam00015  83 RSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162

                         170
                  ....*....|
gi 1918169079 475 LAVSQMDSVT 484
Cdd:pfam00015 163 QAVARMDQVT 172
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 45-175 3.43e-27

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 106.25  E-value: 3.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  45 VLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASlAAINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDE 124
Cdd:cd19407     2 QLRQQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGG-AAVAELLDQAKKSLAQAEKHFAQFKALPKLPGQDEALAAE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1918169079 125 MQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENN 175
Cdd:cd19407    81 LEQSYQAYHDALAELIQFLEAGNIDAFLDQPTQGYQDAFEKAYNAYLAQNN 131
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 26-181 4.14e-26

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 103.92  E-value: 4.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  26 GGLFYSAVSNDRHNFQNSGVLN-AQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPAslaaiNKLLGTAGDSLAKAEAY 104
Cdd:pfam02203   1 GGLGLSGLSRSNDALREVYTNRlQQQAALADAWLLLLQARLTLNRAGIAALLPDAPDA-----AELLARARESLAQSDAA 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1918169079 105 NKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLKAA 181
Cdd:pfam02203  76 WKAYLALPRTPDEEEALAAELKAKYDALQDGLAPLIAALRAGDLDAFFDQPTQKIQPLFEALYNAYLALRKFQNDAA 152
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 46-181 2.30e-19

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 84.44  E-value: 2.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079   46 LNAQQESLSDSVNTLVKTRVTVTRVAIRYlkNQRDPASLAaiNKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEM 125
Cdd:smart00319   3 SSYQQAALSLSRVLLLQARNNLNRAGIRM--MQNNIGSKA--KKLMTAASESLKQAEKNYKSYENMTALPRADRALDAEL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1918169079  126 QKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLKAA 181
Cdd:smart00319  79 KEKFQQYITALQELIQILGNGNLGAFFDQPTQGMQDGFDPAYRDWLQQAVALKGQA 134
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
216-268 1.08e-09

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 54.18  E-value: 1.08e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1918169079  216 HLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEMQQSLVTTVS 268
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
216-265 2.19e-09

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 53.40  E-value: 2.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1918169079 216 HLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEMQQSLVT 265
Cdd:pfam00672   4 RRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 219-263 1.50e-08

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 50.52  E-value: 1.50e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1918169079 219 LKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEMQQSL 263
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 195-263 1.45e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 53.81  E-value: 1.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1918169079 195 TLAAIFLAVIAVLVVIWQGLQ--HLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEMQQSL 263
Cdd:COG5000     8 LLLLLLIALLLLLLALWLALLlaRRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL 78
antiphage_ZorA_1 NF033914
anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel ...
 248-514 3.37e-07

anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.


Pssm-ID: 411475 [Multi-domain]  Cd Length: 619  Bit Score: 53.07  E-value: 3.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 248 EMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLsarTEEQASSLEETA----ASMEELTATVKQNSD-- 321
Cdd:NF033914  291 ELRELAETLKQMQGSLVEMQGGLRGSGEDFARRMSEAAENLNRL---VSDAGSSLGDSAeqsrDALAEVVAALRQTFEka 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 322 NARQATLLAKNASETAARgghVVDNVVRTMNEIadsSQQIAHITGviDSIAFQTNilaLNAAVEAARAGEQgrgfAVVAG 401
Cdd:NF033914  368 NAEVDEALGAAAGGASGK---LEEAMGRVLEKL---EAQIGGLGE--GLGAFQGT---LAEQLDETREQIA----AAQQS 432

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 402 EVRTLASRSAQAAKEIKGLIENSVSRVNtgsEQVSEAGATMKEIVAAVTRVTDIMGEISSasdeQSRgieQVSLAVSQM- 480
Cdd:NF033914  433 AAAAVASASAEAAEALRDGLADALATIR---AEIDRFEAAMRASEGALASQANAIGDATS----QTR---KVADAFSKTa 502

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1918169079 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAA 514
Cdd:NF033914  503 QDVRAAAAPLAQSGERIAGATESMAESVGRTVEA 536
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
198-263 9.93e-06

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 48.13  E-value: 9.93e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1918169079 198 AIFLAVIAVLVVIWqgLQHLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEMQQSL 263
Cdd:PRK10600  131 AVFMALLLVFTIIW--LRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
23-525 7.71e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 45.49  E-value: 7.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  23 VVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASLAAINKLLGTAGDSLAKAE 102
Cdd:COG2770    41 LLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALAL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 103 AYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLKAAT 182
Cdd:COG2770   121 LLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLL 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 183 EENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLHEMQQS 262
Cdd:COG2770   201 VVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADS 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 263 LVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGH 342
Cdd:COG2770   281 LRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALL 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 343 VVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIE 422
Cdd:COG2770   361 LLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALEL 440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 423 NSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQSATAAAALE 502
Cdd:COG2770   441 AAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLL 520

                         490       500
                  ....*....|....*....|...
gi 1918169079 503 DQSEQLRQAVAAFRLNGKANATA 525
Cdd:COG2770   521 LEAEALEVAEELLELEEAALLLA 543
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 82-515 3.74e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 43.33  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079  82 ASLAAINKLLGTAGDSLAKAEAYNKEWQKMPQVNGQNAALTDEMQKSWNQMHKVMRLSIEYLRADNYQAYGDLDAQQAQD 161
Cdd:COG3850     6 LLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 162 DMEAVYNRWRAENNTLLKAATEENQSSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQDI 241
Cdd:COG3850    86 LAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 242 TLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEEQASSLEETAASMEELTATVKQNSD 321
Cdd:COG3850   166 PVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQ 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 322 NARQATLLAKNASETAARGGHVVDNVVRTMNEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAG 401
Cdd:COG3850   246 DALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIAN 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 402 EVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGATMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMD 481
Cdd:COG3850   326 ASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVD 405

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1918169079 482 SVTQQNAALVQQSATAAAALEDQSEQLRQAVAAF 515
Cdd:COG3850   406 VEGGVAGEGGLVVLIVSIIAGGEAIARGEALAAR 439
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
187-259 1.64e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 41.16  E-value: 1.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1918169079 187 SSFTQMQWTLAAIFLAVIAVLVVIWQGLQHLLLKPLNAIMNHIRAIAGGDLTQdITLSGRNEMGQLAAGLHEM 259
Cdd:COG2972   150 RGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEM 221
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 139-257 4.25e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 40.05  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1918169079 139 SIEYLRADNYQAygDLDAQQAQDDMEAVYNRWRAENNTLLKAATEE----NQSSFTQMQ----WTLAAIFLAVIAVLVVI 210
Cdd:COG4192   266 GLPSLRRDELAA--QATLEALAEENNSILEQLRTQISGLVGNSREQlvalNQETAQLVQqsgiLLLAIALLSLLLAVLIN 343

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1918169079 211 WQGLQHLLLKPLNAIMNHIRAIAGGDLTQDITLSGRNEMGQLAAGLH 257
Cdd:COG4192   344 YFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLR 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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