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Conserved domains on  [gi|1916610485|ref|WP_192851259|]
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TonB-dependent receptor plug domain-containing protein, partial [Escherichia coli]

Protein Classification

TonB-dependent receptor( domain architecture ID 1002108)

TonB-dependent receptor may act as a channel to allow import of extracellular nutrients, such as iron-siderophore complexes or non-Fe compounds

Gene Ontology:  GO:0022857
PubMed:  21455261

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TonB-hemin super family cl36974
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 32-295 4.98e-45

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


The actual alignment was detected with superfamily member TIGR01785:

Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 161.41  E-value: 4.98e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQ- 110
Cdd:TIGR01785   2 DTVTVTATRTRQVLSEAPASVSVISGEQIESKQANNLADALNTVPGVDVTGGGRPPGQSINIRGLQDNRVLVVVDGARQn 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 111 -LSDMAKSSGTYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPGETNGLSLWGNIASGDHSTGSGLTWF 189
Cdd:TIGR01785  82 yQRGGAHNGSLFVDPELLKRIEIVKGPSSSLYGSGALGGVVAFRTKDAADLLRPGQLFGGLAKLSYGSNNNSFGGSVAVA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 190 GKTGK-TDALLSVIMRKRGNIYQSDGEHAPNKE-KPAALFAKGSVGITDSNKAGASLRLYRNNTTEPGNSTQTHGD---- 263
Cdd:TIGR01785 162 GRLDDnLDALVAATYRDGGNYRNGNKEEATNSAyVQKNLLAKLGWQLDDAQRLEFSYFTTEGSLDEAQNSGPGTEYvlgs 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1916610485 264 -SGLRDRKTVQNDVQFWYQYAPVDNSLINVKST 295
Cdd:TIGR01785 242 sSTLLASSTRDRSATLTYNWTPEDNPWLDATAS 274
 
Name Accession Description Interval E-value
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 32-295 4.98e-45

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 161.41  E-value: 4.98e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQ- 110
Cdd:TIGR01785   2 DTVTVTATRTRQVLSEAPASVSVISGEQIESKQANNLADALNTVPGVDVTGGGRPPGQSINIRGLQDNRVLVVVDGARQn 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 111 -LSDMAKSSGTYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPGETNGLSLWGNIASGDHSTGSGLTWF 189
Cdd:TIGR01785  82 yQRGGAHNGSLFVDPELLKRIEIVKGPSSSLYGSGALGGVVAFRTKDAADLLRPGQLFGGLAKLSYGSNNNSFGGSVAVA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 190 GKTGK-TDALLSVIMRKRGNIYQSDGEHAPNKE-KPAALFAKGSVGITDSNKAGASLRLYRNNTTEPGNSTQTHGD---- 263
Cdd:TIGR01785 162 GRLDDnLDALVAATYRDGGNYRNGNKEEATNSAyVQKNLLAKLGWQLDDAQRLEFSYFTTEGSLDEAQNSGPGTEYvlgs 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1916610485 264 -SGLRDRKTVQNDVQFWYQYAPVDNSLINVKST 295
Cdd:TIGR01785 242 sSTLLASSTRDRSATLTYNWTPEDNPWLDATAS 274
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 32-282 8.14e-24

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 101.09  E-value: 8.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLS-QTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQ 110
Cdd:COG4771    28 EEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALRLLPGVSvTRSGGRGGSSGISIRGLGGDRVLVLIDGVPV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 111 LSDMAKSSG--TYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPgetnglSLWGNIASGDHSTGSG-LT 187
Cdd:COG4771   108 NNPALGGGGdlSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKKPTDELEG------SVSLGYGSNGNGTYSGsLS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 188 WFGKTGKTDALLSVIMRKRGNI--YQSDGEHAPNKEKPAALFAKGSVGITDSNKAGASLRLYRNNT----TEPGNSTQTH 261
Cdd:COG4771   182 LGGPGDKLSFLLSGSYRDRDGYldYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRdggpPTLGDTEISS 261

                         250       260
                  ....*....|....*....|.
gi 1916610485 262 GDSGLRDRKTVQNDVQFWYQY 282
Cdd:COG4771   262 DNAGDRDTTTDRGNYSLRYNG 282
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 51-291 1.00e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 89.05  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  51 MVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQLS--DMAKSSGTYLDPALVK 128
Cdd:cd01347     1 SVSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASsnYGRGVDLNTIPPELIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 129 RIEVVRGPNSSLYGSGGLGGVVDFRTADAADFlPPGE-TNGLSLWGNIASGDHSTGSGLTwFGKTGKTDALLSVIMRKRG 207
Cdd:cd01347    81 RVEVLKGPSSALYGSGAIGGVVNIITKRPTDE-FGGSvTAGYGSDNSGSSGGGGFDVSGA-LADDGAFGARLYGAYRDGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 208 NIYQSDGEHAPNKEKPAALFAKGSVGITDSNKAGASLRLYRNNTTEPGNS--TQTHGDSGLRDRKTVQNDVQFWYQYAPV 285
Cdd:cd01347   159 GTIDGDGQADDSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTlpANGTGSSLGGGPSSNTNGDRDWDYRDRY 238


                  ....*.
gi 1916610485 286 DNSLIN 291
Cdd:cd01347   239 RKRASL 244
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 44-137 1.61e-17

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 76.15  E-value: 1.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  44 TVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQLSDMAKSSGTY-L 122
Cdd:pfam07715   1 DLRDTPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSISIRGFGSNRVLVLVDGVPLNSGGGGSVDLNsI 80

                          90
                  ....*....|....*
gi 1916610485 123 DPALVKRIEVVRGPN 137
Cdd:pfam07715  81 DPEDIERVEVLKGPA 95
PRK13486 PRK13486
TonB-dependent receptor;
6-174 2.04e-10

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 61.19  E-value: 2.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485   6 IRTVICTLIILPVgLQAATSHSSMVKDTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLS-QTGAG 84
Cdd:PRK13486    1 MRITTLASVVIPC-LGFSASSIAAAEDVMIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRSVEGVDvESGTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  85 RTNGQTFNLRGYDKSGVLVLVDGVRQ--LSDM-----AKSSGTYLDP-ALVKRIEVVRGPNSSLYGSGGLGGVVDFRTAD 156
Cdd:PRK13486   80 KTGGLEISIRGMPASYTLILIDGVRQggSSDVtpngfSAMNTGFMPPlAAIERIEVIRGPMSTLYGSDAMGGVVNIITRK 159

                         170       180
                  ....*....|....*....|...
gi 1916610485 157 AADFLPPGETNGLSL-----WGN 174
Cdd:PRK13486  160 NADKWLSSVNAGLNLqesnkWGN 182
 
Name Accession Description Interval E-value
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 32-295 4.98e-45

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 161.41  E-value: 4.98e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQ- 110
Cdd:TIGR01785   2 DTVTVTATRTRQVLSEAPASVSVISGEQIESKQANNLADALNTVPGVDVTGGGRPPGQSINIRGLQDNRVLVVVDGARQn 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 111 -LSDMAKSSGTYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPGETNGLSLWGNIASGDHSTGSGLTWF 189
Cdd:TIGR01785  82 yQRGGAHNGSLFVDPELLKRIEIVKGPSSSLYGSGALGGVVAFRTKDAADLLRPGQLFGGLAKLSYGSNNNSFGGSVAVA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 190 GKTGK-TDALLSVIMRKRGNIYQSDGEHAPNKE-KPAALFAKGSVGITDSNKAGASLRLYRNNTTEPGNSTQTHGD---- 263
Cdd:TIGR01785 162 GRLDDnLDALVAATYRDGGNYRNGNKEEATNSAyVQKNLLAKLGWQLDDAQRLEFSYFTTEGSLDEAQNSGPGTEYvlgs 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1916610485 264 -SGLRDRKTVQNDVQFWYQYAPVDNSLINVKST 295
Cdd:TIGR01785 242 sSTLLASSTRDRSATLTYNWTPEDNPWLDATAS 274
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 32-291 1.56e-38

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 143.71  E-value: 1.56e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQN----TVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDG 107
Cdd:TIGR01786   1 DTITVTATRTADpqrrDLSVTPASVSVISREQLKSQQVRNLRDLLRYEPGVSVVEGGRGGSQGINIRGLDKNRVAVLVDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 108 VRQLSDMAKSSGT-----YLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPGETNGLSLWGNIASGDHST 182
Cdd:TIGR01786  81 IRQNTSYGGQGSTfyainSIDPELIKSIEIVKGASSSLYGSGALGGVVAFRTKDAADLLKPGKDLGGLSKLGYSSANNRF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 183 GSGLTWFGKTGKTDALLSVIMRKRGNIYQSDGEHAPNKEKP----------AALFAKGSVGITDSNKAGASLRLYRNNTT 252
Cdd:TIGR01786 161 TQSVAAAGRNDDVDALVQATYRRGHELKNGNKANIGNESKRskpnpsdyksQSFLAKLGWQLNDAHRLGLSLEYTQTDYD 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1916610485 253 EPGNSTQTHGDSG-----------LRDRKTVQNDVQFWYQYAPvDNSLIN 291
Cdd:TIGR01786 241 EPEMTNTSYLTKPlgapllsstvvLGDSKTRDRRTGLDYELNP-DNSWLD 289
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 32-282 8.14e-24

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 101.09  E-value: 8.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLS-QTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQ 110
Cdd:COG4771    28 EEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALRLLPGVSvTRSGGRGGSSGISIRGLGGDRVLVLIDGVPV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 111 LSDMAKSSG--TYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPgetnglSLWGNIASGDHSTGSG-LT 187
Cdd:COG4771   108 NNPALGGGGdlSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKKPTDELEG------SVSLGYGSNGNGTYSGsLS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 188 WFGKTGKTDALLSVIMRKRGNI--YQSDGEHAPNKEKPAALFAKGSVGITDSNKAGASLRLYRNNT----TEPGNSTQTH 261
Cdd:COG4771   182 LGGPGDKLSFLLSGSYRDRDGYldYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRdggpPTLGDTEISS 261

                         250       260
                  ....*....|....*....|.
gi 1916610485 262 GDSGLRDRKTVQNDVQFWYQY 282
Cdd:COG4771   262 DNAGDRDTTTDRGNYSLRYNG 282
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
32-260 1.23e-21

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 94.89  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQtFNLRG--YDKSGVLVLVDGVR 109
Cdd:COG1629     2 EEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLLRRVPGVSVTSAGGGAGQ-ISIRGfgGGGNRVLVLVDGVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 110 Q-LSDMAKSSGTYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADaadflpPGETNGLSLWGNIASGDHSTGSgLTW 188
Cdd:COG1629    81 LnDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKK------PKDGKGGEVSASYGSYGTYRAS-LSL 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916610485 189 FGKTGKTDALLSvimrkrGNIYQSDGEHAPNKEKPAALFAKGSVGITDSNKAGASLRLYRNNTTEPGNSTQT 260
Cdd:COG1629   154 SGGNGKLAYRLS------ASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLA 219
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 51-291 1.00e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 89.05  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  51 MVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQLS--DMAKSSGTYLDPALVK 128
Cdd:cd01347     1 SVSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASsnYGRGVDLNTIPPELIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 129 RIEVVRGPNSSLYGSGGLGGVVDFRTADAADFlPPGE-TNGLSLWGNIASGDHSTGSGLTwFGKTGKTDALLSVIMRKRG 207
Cdd:cd01347    81 RVEVLKGPSSALYGSGAIGGVVNIITKRPTDE-FGGSvTAGYGSDNSGSSGGGGFDVSGA-LADDGAFGARLYGAYRDGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 208 NIYQSDGEHAPNKEKPAALFAKGSVGITDSNKAGASLRLYRNNTTEPGNS--TQTHGDSGLRDRKTVQNDVQFWYQYAPV 285
Cdd:cd01347   159 GTIDGDGQADDSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTlpANGTGSSLGGGPSSNTNGDRDWDYRDRY 238


                  ....*.
gi 1916610485 286 DNSLIN 291
Cdd:cd01347   239 RKRASL 244
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 44-137 1.61e-17

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 76.15  E-value: 1.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  44 TVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQLSDMAKSSGTY-L 122
Cdd:pfam07715   1 DLRDTPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSISIRGFGSNRVLVLVDGVPLNSGGGGSVDLNsI 80

                          90
                  ....*....|....*
gi 1916610485 123 DPALVKRIEVVRGPN 137
Cdd:pfam07715  81 DPEDIERVEVLKGPA 95
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
34-252 6.97e-14

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 70.29  E-value: 6.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  34 ITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLS-QTGAGRTNGQTFNLRGYDKSGVLVLVDGVRQLS 112
Cdd:COG4206     1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALRRVPGVQvSSSGGPGSAASISIRGLGSNQTLVLIDGVPLND 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 113 DMAKSSG-TYLDPALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADaadflpPGETNGLSLWGNIASGDHSTGSgLTWFGK 191
Cdd:COG4206    81 PSLGGVDlSLIPPDDIERIEVLKGAASALYGSDAIGGVINITTKK------GKKGFKGSVSASYGSFGTRRLS-ASLSGG 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916610485 192 TGKTDALLSVIMRKRGNI-YQSDGEHAPNKEKPAALFAKGSVGITDSNKAGASLRLYRNNTT 252
Cdd:COG4206   154 AGKFSYSLSASYRRSDGYrYNDPDLRNNDGYENTSLNARLGYKLGDNGSLSLSGGYSDSERG 215
PRK13486 PRK13486
TonB-dependent receptor;
6-174 2.04e-10

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 61.19  E-value: 2.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485   6 IRTVICTLIILPVgLQAATSHSSMVKDTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLS-QTGAG 84
Cdd:PRK13486    1 MRITTLASVVIPC-LGFSASSIAAAEDVMIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRSVEGVDvESGTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  85 RTNGQTFNLRGYDKSGVLVLVDGVRQ--LSDM-----AKSSGTYLDP-ALVKRIEVVRGPNSSLYGSGGLGGVVDFRTAD 156
Cdd:PRK13486   80 KTGGLEISIRGMPASYTLILIDGVRQggSSDVtpngfSAMNTGFMPPlAAIERIEVIRGPMSTLYGSDAMGGVVNIITRK 159

                         170       180
                  ....*....|....*....|...
gi 1916610485 157 AADFLPPGETNGLSL-----WGN 174
Cdd:PRK13486  160 NADKWLSSVNAGLNLqesnkWGN 182
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 47-215 2.18e-10

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 61.27  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  47 ETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGA-GRTNGQTFNLRGYDKSGVL--VLVDGVRQLSDMAKSSgtyLD 123
Cdd:TIGR01783   1 DIPQSVSVITRQELEDQQAGSLSEALQRVPGVVVGGSgGTTQFGNITIRGFGLEVDIdnVYLDGVPLLSRGNLAI---VD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 124 PALVKRIEVVRGPNSSLYGSGGLGGVVDFRTADAADFLPPGETNGLSLWGNIAS-GDHStgsglTWFGKTGKTDALLSVI 202
Cdd:TIGR01783  78 PAMVERVEVLRGPASLLYGGSAPGGVINIVTKRPQDEPKGSVTFGAGTRSGYRTaFDLG-----GPLGADGTFRGRLNGA 152

                         170
                  ....*....|...
gi 1916610485 203 MRKRGNIYQSDGE 215
Cdd:TIGR01783 153 RQDGDSFYDGAGE 165
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
44-137 3.23e-10

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 60.66  E-value: 3.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  44 TVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGRTNGQTFNLRGYDKSGVlVLVDGVRQLSdmakssGTYLD 123
Cdd:COG4774     5 PLLDTPQSVTVVTRELIEDQGATSLADALRNVPGVTFGAGEGGNGDSFSIRGFSASGD-IYVDGLRDPG------QYRRD 77

                          90
                  ....*....|....
gi 1916610485 124 PALVKRIEVVRGPN 137
Cdd:COG4774    78 TFNLERVEVLKGPA 91
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 21-137 5.30e-09

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 56.83  E-value: 5.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  21 QAATSHSSMVKDTITIVATGNQNTVF----------------ETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAG 84
Cdd:COG4773    22 AAAAAAEATTLPEVTVTGTAEGTGGYtakssstatkldtplrETPQSVSVVTRQLIEDQGATTLDDALRNVPGVTVSSYD 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1916610485  85 RTNGQTFNLRGYDKSGVLVlvDGVRQLSdmakSSGTYLDPALVKRIEVVRGPN 137
Cdd:COG4773   102 GGGRDSFSIRGFSIDNYLR--DGLPLGG----FGGGQPDTANLERVEVLKGPA 148
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
8-138 1.28e-08

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 55.78  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485   8 TVICTLIILpvglqaaTSHSSMVK--DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAgr 85
Cdd:PRK13484   12 AVMCSAVIS-------SGYASSDKkeDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGISITGG-- 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  86 TNGQTFNLRGYDKSGVLVLVDGVRQLSDMAKSSGT------YLDPA-LVKRIEVVRGPNS 138
Cdd:PRK13484   83 NEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSggfeagFIPPVeAIERIEVIRGPMS 142
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
11-260 2.92e-08

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 54.55  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  11 CTLIILPVGLQAATSHSSMVKDTITIVATG-NQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGL---SQTGAG-R 85
Cdd:COG4772     3 RALAAALLLAAAAAAEAATTLETVVVTGSRaAEARLKDVPGSVSVVDREELENQAATSLREVLRRVPGVnvqEEDGFGlR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  86 TNgqtFNLRGYD---KSGVLVLVDGVrqlsDMAksSGTYLDPAL--------VKRIEVVRGPNSSLYGSGGLGGVVDFRT 154
Cdd:COG4772    83 PN---IGIRGLGprrSRGITLLEDGI----PIA--PAPYGDPAAyyfpdlerMERIEVLRGAAALRYGPQTVGGAINFVT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485 155 ADAadflPPGETNGLSLWGniasGDHSTGSGLTWFGKT-GKTDALLSvimrkrGNIYQSDGEHAPNKEKPAALFAKGSVG 233
Cdd:COG4772   154 RTI----PTAFGGELRVTG----GSFGYRRTHASVGGTvGNFGYLVE------YSRKRGDGFRDNSGFDINDFNAKLGYR 219

                         250       260
                  ....*....|....*....|....*..
gi 1916610485 234 ITDSNKAGASLRLYRNNTTEPGNSTQT 260
Cdd:COG4772   220 LSDRQELTLKFQYYDEDANTPGGLTDA 246
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 30-137 6.11e-08

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 53.74  E-value: 6.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  30 VKDTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAGLSQTGAGrTNGQTFNLRGYDKSGVLVLVDGVR 109
Cdd:PRK10064   29 DGETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEG-DNRKGVSIRGLDSSYTLILIDGKR 107

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1916610485 110 QLSDMAKSSGTYLD----PA-LVKRIEVVRGPN 137
Cdd:PRK10064  108 VNSRNAVFRHNDFDlnwiPVdAIERIEVVRGPM 140
PRK13513 PRK13513
ligand-gated channel protein;
1-137 2.03e-07

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 52.08  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485   1 MYMNVIRTVICTLII---LPVGLQAATSHSSMVKDTITIV-ATGNQNTVFETPSMVSVVTNDT--PWSQNAVTSAgmLKG 74
Cdd:PRK13513    1 VNQRFRKTHKAALVIaaaISSQAYAAEKTNTATPTDTMVVtASGFQQRIQDAPASISVVTREQleNKAYRDVTDA--LKD 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1916610485  75 VAGLSQTGAGRTNgqTFNLRGYDKSGVLVLVDGVRQL-------SDMAKSSGTYLDP-ALVKRIEVVRGPN 137
Cdd:PRK13513   79 VPGVVVTGGGSTS--DISIRGMAAKYTLILVDGKRVDtrstrpnSDGSGIEQGWLPPlAAIERIEVVRGPM 147
PRK13483 PRK13483
ligand-gated channel protein;
8-138 2.65e-07

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 51.70  E-value: 2.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485   8 TVICTLIILPVGLQAATSHSSMvkDTITIVATGNQNTVFETPSMVSVVTNDTPWSQ--NAVTSAgmLKGVAGLSQTGAGr 85
Cdd:PRK13483   12 LCLLPAVFVTHALAQAAPDKTM--ETVVVTASGYEQQIRDAPASISVITREDLENRfyRDLTDA--LLDVPGVVVTGGG- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1916610485  86 tNGQTFNLRGYDKSGVLVLVDGVRQLS-------DMAKSSGTYLDP-ALVKRIEVVRGPNS 138
Cdd:PRK13483   87 -DRTDISLRGMGSQYTLILVDGKRQSSretrpnsDGPGVEQAWTPPlAAIERIEVIRGPMS 146
TonB-B12 TIGR01779
TonB-dependent vitamin B12 receptor; This model represents the TonB-dependent outer membrane ...
 32-138 4.68e-07

TonB-dependent vitamin B12 receptor; This model represents the TonB-dependent outer membrane receptor found in gamma proteobacteria responsible for translocating the cobalt-containing vitamin B12 (cobalamin). [Transport and binding proteins, Other, Transport and binding proteins, Porins]


Pssm-ID: 273802 [Multi-domain]  Cd Length: 614  Bit Score: 51.02  E-value: 4.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  32 DTITIVATGNQNTVFETPSMVSVVTNDTPWSQNAVTSAGMLKGVAG--LSQTGaGRTNGQTFNLRGYDKSGVLVLVDGVR 109
Cdd:TIGR01779  29 DTVVVTANRFAQTASQTLAPVTIITRQDIERTQAKSLPELLRRLPGvsIAQNG-GRGQNTSLFLRGTESDHVLVLIDGIR 107

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1916610485 110 QLSdmAKSSGTYLDP---ALVKRIEVVRGPNS 138
Cdd:TIGR01779 108 FGS--AAAGAADFQQlpvELVERIEYVRGPRS 137
btuB PRK10641
TonB-dependent vitamin B12 receptor BtuB;
35-136 3.76e-04

TonB-dependent vitamin B12 receptor BtuB;


Pssm-ID: 236730 [Multi-domain]  Cd Length: 614  Bit Score: 41.90  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916610485  35 TIVATGNQntvFETP-----SMVSVVTND--TPWSQNAVTSAgM--LKGVAgLSQTGAGRTNGQTFnLRGYDKSGVLVLV 105
Cdd:PRK10641   27 TLVVTANR---FQQPvstvlAPTTVVTRDdiDRWQSKSVNDV-LrrLPGVD-IAQNGGLGQLSSLF-IRGTNSSHVLVLI 100

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1916610485 106 DGVR-QLSDMAKSSGTYLDP-ALVKRIEVVRGP 136
Cdd:PRK10641  101 DGVRlNQAGISGSADLSQIPiSLVQRIEYIRGP 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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