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Conserved domains on  [gi|1915720151|ref|WP_192818729|]
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NAD(P)H-hydrate dehydratase [Infirmifilum lucidum]

Protein Classification

bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase( domain architecture ID 11145907)

bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, allowing the repair of both epimers of NAD(P)HX

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 232-510 1.02e-101

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


:

Pssm-ID: 439833  Cd Length: 280  Bit Score: 307.05  E-value: 1.02e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 232 FIPPRRPDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETangtvaya 311
Cdd:COG0063    13 LLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPLPEE-------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 312 nlERLLKLAEWADIVVVGPGLTTEEETSRLVREVVARVDKPVVIDGDGLTAVSASPEVLRKRSKPTVLTPHLGEMSRLTG 391
Cdd:COG0063    85 --DELLELLERADAVVIGPGLGRDEETRELLRALLEAADKPLVLDADALNLLAEDPELLAALPAPTVLTPHPGEFARLLG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 392 VGVDEIKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRM 471
Cdd:COG0063   163 CSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAAAA 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1915720151 472 GVFVHGAAGDYVAARRGIdGVTATSIMHALPRVLQALRE 510
Cdd:COG0063   243 GVYLHGLAGDLAAEERGR-GLLASDLIEALPAALRELLE 280
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 25-193 5.38e-60

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


:

Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 195.52  E-value: 5.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  25 EILMENAGAAVARVVDMVAGVRNLLVAVVAGTGNNGGDGLVAARHLASNGAEVRVFVVGREDKMTDLARINLARVRSAGI 104
Cdd:pfam03853   2 AVLMENAGRAAARVLKALLSPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKKLGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 105 PVefVSEENISELRSELEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIVGVDIPSGVNGDTGQVMGVAVRADYT 184
Cdd:pfam03853  82 KI--VTDNPDEDLEKLLSPVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPSGLDADTGAVLGTAVRADHT 159


                  ....*....
gi 1915720151 185 VTFGLPKPG 193
Cdd:pfam03853 160 VTFGAPKPG 168
 
Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 232-510 1.02e-101

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 307.05  E-value: 1.02e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 232 FIPPRRPDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETangtvaya 311
Cdd:COG0063    13 LLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPLPEE-------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 312 nlERLLKLAEWADIVVVGPGLTTEEETSRLVREVVARVDKPVVIDGDGLTAVSASPEVLRKRSKPTVLTPHLGEMSRLTG 391
Cdd:COG0063    85 --DELLELLERADAVVIGPGLGRDEETRELLRALLEAADKPLVLDADALNLLAEDPELLAALPAPTVLTPHPGEFARLLG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 392 VGVDEIKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRM 471
Cdd:COG0063   163 CSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAAAA 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1915720151 472 GVFVHGAAGDYVAARRGIdGVTATSIMHALPRVLQALRE 510
Cdd:COG0063   243 GVYLHGLAGDLAAEERGR-GLLASDLIEALPAALRELLE 280
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 3-504 2.48e-81

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 262.30  E-value: 2.48e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   3 VASVSDIKRIDELASARYGVSHEILMENAG-AAVARVVDMVAGVRNLLVavVAGTGNNGGDGLVAARHLASNGAEVRVFV 81
Cdd:PRK10565   17 VWPADDIRRGEREAADALGLTLYELMLRAGeAAFQVARSAYPDARHWLV--LCGHGNNGGDGYVVARLAQAAGIDVTLLA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  82 VGREDKMTDLARINLARVRSAGipvefvSEENISELRSElEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIVGV 161
Cdd:PRK10565   95 QESDKPLPEEAALAREAWLNAG------GEIHAADIVWP-ESVDLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVAL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 162 DIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLYPGAEYAGEIFVSRISYpRALLEDESIQVETND----PVFIPPRR 237
Cdd:PRK10565  168 DIPSGLLAETGATPGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGL-DSWLAGQEAPIQRFDaeqlSQWLKPRR 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 238 PDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVAS-IVPHLGSKASEVVYEPLAETangtvayanLERL 316
Cdd:PRK10565  247 PTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLTRSEnIAPLLTARPELMVHELTPDS---------LEES 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 317 LklaEWADIVVVGPGLTtEEETSRLVREVVARVDKPVVIDGDGLTAVSASPEVLRKRskptVLTPHLGEMSRLTGVGVDE 396
Cdd:PRK10565  318 L---EWADVVVIGPGLG-QQEWGKKALQKVENFRKPMLWDADALNLLAINPDKRHNR----VITPHPGEAARLLGCSVAE 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 397 IKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVH 476
Cdd:PRK10565  390 IESDRLLSARRLVKRYGGVVVLKGAGTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAGCVAH 469

                         490       500
                  ....*....|....*....|....*...
gi 1915720151 477 GAAGDYVAARRGIDGVTATSIMHALPRV 504
Cdd:PRK10565  470 GAAADVLAARFGTRGMLATDLFSTLQRI 497
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 238-502 7.36e-80

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 250.22  E-value: 7.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 238 PDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETANgtvayanlERLL 317
Cdd:cd01171     1 PDSHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPLLETDI--------EELL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 318 KLAEWADIVVVGPGLTTEEETSRLVREVVARvDKPVVIDGDGLTAVSASPEvLRKRSKPTVLTPHLGEMSRLTGVGVDEI 397
Cdd:cd01171    73 ELLERADAVVIGPGLGRDEEAAEILEKALAK-DKPLVLDADALNLLADEPS-LIKRYGPVVLTPHPGEFARLLGALVEEI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 398 KQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVHG 477
Cdd:cd01171   151 QADRLAAAREAAAKLGATVVLKGAVTVIADPDGRVYVNPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHG 230

                         250       260
                  ....*....|....*....|....*
gi 1915720151 478 AAGDyVAARRGIDGVTATSIMHALP 502
Cdd:cd01171   231 LAGD-LAAKKKGAGLTAADLVAEIP 254
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 232-505 2.27e-64

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 210.32  E-value: 2.27e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 232 FIPPRRPDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAEtangtvaya 311
Cdd:TIGR00196  11 TLPLRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVHRLMW--------- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 312 NLERLLKLAEWADIVVVGPGLTTEEETSRLVREVvARVDKPVVIDGDGLTAVsaspEVLRKRSKPTVLTPHLGEMSRLTG 391
Cdd:TIGR00196  82 KVDEDEELLERYDVVVIGPGLGQDPSFKKAVEEV-LELDKPVVLDADALNLL----TYNQKREGEVILTPHPGEFKRLLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 392 VgvDEIKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRM 471
Cdd:TIGR00196 157 V--NEIQGDRLEAAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACN 234

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1915720151 472 GVFVHGAAGDYVAARRGIDGVTATSIMHALPRVL 505
Cdd:TIGR00196 235 AAFAHGLAGDLALKNHGAYGLTALDLIEKIPRVC 268
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 25-193 5.38e-60

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 195.52  E-value: 5.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  25 EILMENAGAAVARVVDMVAGVRNLLVAVVAGTGNNGGDGLVAARHLASNGAEVRVFVVGREDKMTDLARINLARVRSAGI 104
Cdd:pfam03853   2 AVLMENAGRAAARVLKALLSPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKKLGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 105 PVefVSEENISELRSELEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIVGVDIPSGVNGDTGQVMGVAVRADYT 184
Cdd:pfam03853  82 KI--VTDNPDEDLEKLLSPVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPSGLDADTGAVLGTAVRADHT 159


                  ....*....
gi 1915720151 185 VTFGLPKPG 193
Cdd:pfam03853 160 VTFGAPKPG 168
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 248-503 1.83e-50

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 172.93  E-value: 1.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 248 ALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETangtvayanlERLLKLAEWADIVV 327
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPET----------SSILEKLSRYDAVV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 328 VGPGLTTEEETSRLVREVVARvDKPVVIDGDGLTAVSASPEVlRKRSKPTVLTPHLGEMSRLTGVgVDEIKQDRIGVLRR 407
Cdd:pfam01256  71 IGPGLGRDEKGKAALEEVLAK-DCPLVIDADALNLLAINNEK-PAREGPTVLTPHPGEFERLCGL-AGILGDDRLEAARE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 408 ACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVHGAAGDYVAARR 487
Cdd:pfam01256 148 LAQKLNGTILLKGNVTVIAAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENH 227

                         250
                  ....*....|....*.
gi 1915720151 488 GIDgVTATSIMHALPR 503
Cdd:pfam01256 228 GVY-MLPTLLSKIIPR 242
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 2-215 1.16e-44

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 156.42  E-value: 1.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   2 KVASVSDIKRIDELASARYGVSHEILMENAGAAVARVVdMVAGVRNLLVAVVAGTGNNGGDGLVAARHLAsnGAEVRVFV 81
Cdd:TIGR00197   1 KVVVSPKDMAIDKENAEYLGLTLDLLMENAGKAVAQAV-LQAYPLAGHVIIFCGPGNNGGDGFVVARHLK--GFGVEVFL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  82 VGREDKM--TDLARINLARVRSAGIPVEFVSEENiselrseLEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIV 159
Cdd:TIGR00197  78 LKKEKRIecTEQAEVNLKALKVGGISIDEGNLVK-------PEDCDVIIDAILGTGFKGKLREPFKTIVESINELPAPIV 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915720151 160 GVDIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLyPGAEYAGEIFVSRISYPR 215
Cdd:TIGR00197 151 SVDIPSGLDVDTGAIEGPAVNADLTITFHAIKPCLLS-DRADVTGELKVGGIGIPP 205
PLN03050 PLN03050
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 5-224 1.52e-26

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215551 [Multi-domain]  Cd Length: 246  Bit Score: 108.04  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   5 SVSDIKRIDELASARYGVSHEILMENAGAAVARVVDMVAGVRNLL--------VAVVAGTGNNGGDGLVAARHLASNGAE 76
Cdd:PLN03050   10 NAQDAAALDEELMSTPGFSLEQLMELAGLSVAEAVYEVADGEKASnppgrhprVLLVCGPGNNGGDGLVAARHLAHFGYE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  77 VRVFVVGREDKMTdlaRINLA-RVRSAGIPVEFVSEENISELRSELEYSDVVVDALFGIGLNKPVEGVYRKAIEAVN--- 152
Cdd:PLN03050   90 VTVCYPKQSSKPH---YENLVtQCEDLGIPFVQAIGGTNDSSKPLETTYDVIVDAIFGFSFHGAPRAPFDTLLAQMVqqq 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1915720151 153 SSGAIIVGVDIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLYPGAEYAGEIFVsrisyPRALLEDESIQ 224
Cdd:PLN03050  167 KSPPPIVSVDVPSGWDVDEGDVSGTGMRPDVLVSLTAPKLSAKKFEGRHFVGGRFL-----PPAIAEKYGLQ 233
 
Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 232-510 1.02e-101

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 307.05  E-value: 1.02e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 232 FIPPRRPDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETangtvaya 311
Cdd:COG0063    13 LLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPLPEE-------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 312 nlERLLKLAEWADIVVVGPGLTTEEETSRLVREVVARVDKPVVIDGDGLTAVSASPEVLRKRSKPTVLTPHLGEMSRLTG 391
Cdd:COG0063    85 --DELLELLERADAVVIGPGLGRDEETRELLRALLEAADKPLVLDADALNLLAEDPELLAALPAPTVLTPHPGEFARLLG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 392 VGVDEIKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRM 471
Cdd:COG0063   163 CSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAAAA 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1915720151 472 GVFVHGAAGDYVAARRGIdGVTATSIMHALPRVLQALRE 510
Cdd:COG0063   243 GVYLHGLAGDLAAEERGR-GLLASDLIEALPAALRELLE 280
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 1-510 2.34e-101

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 314.11  E-value: 2.34e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   1 MKVASVSDIKRIDELASARYGVSHEILMENAGAAVARVVDMVAGVRNLLVAVVAGTGNNGGDGLVAARHLASNGAEVRVF 80
Cdd:COG0062     1 MKLLTAAQMRALDRAAIEALGIPGLVLMERAGRAVARAIRRRFPSAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVTVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  81 VVGREDKMTDLARINLARVRSAGIPVEFVSEEniselRSELEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIVG 160
Cdd:COG0062    81 LLGDPEKLSGDAAANLERLKAAGIPILELDDE-----LPELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 161 VDIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLYPGAEYAGEIFVSRISYPRALLEDESIQVETNDPV---FIPPRR 237
Cdd:COG0062   156 VDIPSGLDADTGEVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADIGIGIPAAAEAPAALLLLADLlalLLPPRR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 238 PDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETANGTVAYANLERLL 317
Cdd:COG0062   236 RSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 318 KLAEWADIVVVGPGLTTEEETSRLVREVVARVDKPVVIDGDGLTAVSASPEVLRKRSKPTVLTPHLGEMSRLtgvgvdei 397
Cdd:COG0062   316 GGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAA-------- 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 398 kqDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVHG 477
Cdd:COG0062   388 --AALLAAAAAAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAA 465

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1915720151 478 AAGDYVAARRGIDGVTATSIMHALPRVLQALRE 510
Cdd:COG0062   466 AAAAAAAALAAALLAAAAALIALLLAAALLLLL 498
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 3-504 2.48e-81

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 262.30  E-value: 2.48e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   3 VASVSDIKRIDELASARYGVSHEILMENAG-AAVARVVDMVAGVRNLLVavVAGTGNNGGDGLVAARHLASNGAEVRVFV 81
Cdd:PRK10565   17 VWPADDIRRGEREAADALGLTLYELMLRAGeAAFQVARSAYPDARHWLV--LCGHGNNGGDGYVVARLAQAAGIDVTLLA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  82 VGREDKMTDLARINLARVRSAGipvefvSEENISELRSElEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIVGV 161
Cdd:PRK10565   95 QESDKPLPEEAALAREAWLNAG------GEIHAADIVWP-ESVDLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVAL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 162 DIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLYPGAEYAGEIFVSRISYpRALLEDESIQVETND----PVFIPPRR 237
Cdd:PRK10565  168 DIPSGLLAETGATPGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGL-DSWLAGQEAPIQRFDaeqlSQWLKPRR 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 238 PDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVAS-IVPHLGSKASEVVYEPLAETangtvayanLERL 316
Cdd:PRK10565  247 PTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLTRSEnIAPLLTARPELMVHELTPDS---------LEES 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 317 LklaEWADIVVVGPGLTtEEETSRLVREVVARVDKPVVIDGDGLTAVSASPEVLRKRskptVLTPHLGEMSRLTGVGVDE 396
Cdd:PRK10565  318 L---EWADVVVIGPGLG-QQEWGKKALQKVENFRKPMLWDADALNLLAINPDKRHNR----VITPHPGEAARLLGCSVAE 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 397 IKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVH 476
Cdd:PRK10565  390 IESDRLLSARRLVKRYGGVVVLKGAGTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAGCVAH 469

                         490       500
                  ....*....|....*....|....*...
gi 1915720151 477 GAAGDYVAARRGIDGVTATSIMHALPRV 504
Cdd:PRK10565  470 GAAADVLAARFGTRGMLATDLFSTLQRI 497
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 238-502 7.36e-80

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 250.22  E-value: 7.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 238 PDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETANgtvayanlERLL 317
Cdd:cd01171     1 PDSHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPLLETDI--------EELL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 318 KLAEWADIVVVGPGLTTEEETSRLVREVVARvDKPVVIDGDGLTAVSASPEvLRKRSKPTVLTPHLGEMSRLTGVGVDEI 397
Cdd:cd01171    73 ELLERADAVVIGPGLGRDEEAAEILEKALAK-DKPLVLDADALNLLADEPS-LIKRYGPVVLTPHPGEFARLLGALVEEI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 398 KQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVHG 477
Cdd:cd01171   151 QADRLAAAREAAAKLGATVVLKGAVTVIADPDGRVYVNPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHG 230

                         250       260
                  ....*....|....*....|....*
gi 1915720151 478 AAGDyVAARRGIDGVTATSIMHALP 502
Cdd:cd01171   231 LAGD-LAAKKKGAGLTAADLVAEIP 254
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 232-505 2.27e-64

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 210.32  E-value: 2.27e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 232 FIPPRRPDTHKGDYGKALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAEtangtvaya 311
Cdd:TIGR00196  11 TLPLRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVHRLMW--------- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 312 NLERLLKLAEWADIVVVGPGLTTEEETSRLVREVvARVDKPVVIDGDGLTAVsaspEVLRKRSKPTVLTPHLGEMSRLTG 391
Cdd:TIGR00196  82 KVDEDEELLERYDVVVIGPGLGQDPSFKKAVEEV-LELDKPVVLDADALNLL----TYNQKREGEVILTPHPGEFKRLLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 392 VgvDEIKQDRIGVLRRACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRM 471
Cdd:TIGR00196 157 V--NEIQGDRLEAAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACN 234

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1915720151 472 GVFVHGAAGDYVAARRGIDGVTATSIMHALPRVL 505
Cdd:TIGR00196 235 AAFAHGLAGDLALKNHGAYGLTALDLIEKIPRVC 268
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 25-193 5.38e-60

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 195.52  E-value: 5.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  25 EILMENAGAAVARVVDMVAGVRNLLVAVVAGTGNNGGDGLVAARHLASNGAEVRVFVVGREDKMTDLARINLARVRSAGI 104
Cdd:pfam03853   2 AVLMENAGRAAARVLKALLSPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKKLGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 105 PVefVSEENISELRSELEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIVGVDIPSGVNGDTGQVMGVAVRADYT 184
Cdd:pfam03853  82 KI--VTDNPDEDLEKLLSPVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPSGLDADTGAVLGTAVRADHT 159


                  ....*....
gi 1915720151 185 VTFGLPKPG 193
Cdd:pfam03853 160 VTFGAPKPG 168
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 248-503 1.83e-50

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 172.93  E-value: 1.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 248 ALFVAGSRQYLGAPLFSSMSFLLAGGGYSRLATVASIVPHLGSKASEVVYEPLAETangtvayanlERLLKLAEWADIVV 327
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPET----------SSILEKLSRYDAVV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 328 VGPGLTTEEETSRLVREVVARvDKPVVIDGDGLTAVSASPEVlRKRSKPTVLTPHLGEMSRLTGVgVDEIKQDRIGVLRR 407
Cdd:pfam01256  71 IGPGLGRDEKGKAALEEVLAK-DCPLVIDADALNLLAINNEK-PAREGPTVLTPHPGEFERLCGL-AGILGDDRLEAARE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 408 ACRDLNSIIVLKGAHTLVGMPDGRVYINLSGNPGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVHGAAGDYVAARR 487
Cdd:pfam01256 148 LAQKLNGTILLKGNVTVIAAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENH 227

                         250
                  ....*....|....*.
gi 1915720151 488 GIDgVTATSIMHALPR 503
Cdd:pfam01256 228 GVY-MLPTLLSKIIPR 242
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 2-215 1.16e-44

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 156.42  E-value: 1.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   2 KVASVSDIKRIDELASARYGVSHEILMENAGAAVARVVdMVAGVRNLLVAVVAGTGNNGGDGLVAARHLAsnGAEVRVFV 81
Cdd:TIGR00197   1 KVVVSPKDMAIDKENAEYLGLTLDLLMENAGKAVAQAV-LQAYPLAGHVIIFCGPGNNGGDGFVVARHLK--GFGVEVFL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  82 VGREDKM--TDLARINLARVRSAGIPVEFVSEENiselrseLEYSDVVVDALFGIGLNKPVEGVYRKAIEAVNSSGAIIV 159
Cdd:TIGR00197  78 LKKEKRIecTEQAEVNLKALKVGGISIDEGNLVK-------PEDCDVIIDAILGTGFKGKLREPFKTIVESINELPAPIV 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915720151 160 GVDIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLyPGAEYAGEIFVSRISYPR 215
Cdd:TIGR00197 151 SVDIPSGLDVDTGAIEGPAVNADLTITFHAIKPCLLS-DRADVTGELKVGGIGIPP 205
PLN03050 PLN03050
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 5-224 1.52e-26

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215551 [Multi-domain]  Cd Length: 246  Bit Score: 108.04  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   5 SVSDIKRIDELASARYGVSHEILMENAGAAVARVVDMVAGVRNLL--------VAVVAGTGNNGGDGLVAARHLASNGAE 76
Cdd:PLN03050   10 NAQDAAALDEELMSTPGFSLEQLMELAGLSVAEAVYEVADGEKASnppgrhprVLLVCGPGNNGGDGLVAARHLAHFGYE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  77 VRVFVVGREDKMTdlaRINLA-RVRSAGIPVEFVSEENISELRSELEYSDVVVDALFGIGLNKPVEGVYRKAIEAVN--- 152
Cdd:PLN03050   90 VTVCYPKQSSKPH---YENLVtQCEDLGIPFVQAIGGTNDSSKPLETTYDVIVDAIFGFSFHGAPRAPFDTLLAQMVqqq 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1915720151 153 SSGAIIVGVDIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLYPGAEYAGEIFVsrisyPRALLEDESIQ 224
Cdd:PLN03050  167 KSPPPIVSVDVPSGWDVDEGDVSGTGMRPDVLVSLTAPKLSAKKFEGRHFVGGRFL-----PPAIAEKYGLQ 233
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 5-208 3.33e-23

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 102.24  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   5 SVSDIKRIDELASARYGVSHEILMENAGAAVARVVDMV-AGVRNLLVAVVAGTGNNGGDGLVAARHLASNGAEVRVFVVG 83
Cdd:PLN03049   16 SQREAIAIDEHLMGPLGFSVDQLMELAGLSVASAIAEVySPSEYRRVLALCGPGNNGGDGLVAARHLHHFGYKPSICYPK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  84 REDKmtDLARINLARVRSAGIPveFVSEEnisELRSEL-EYSDVVVDALFGI---GLNK-PVEGVYRKAIEAVNSsgAII 158
Cdd:PLN03049   96 RTDK--PLYNGLVTQLESLSVP--FLSVE---DLPSDLsSQFDIVVDAMFGFsfhGAPRpPFDDLIQKLVRAAGP--PPI 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1915720151 159 VGVDIPSGVNGDTGQVMGVAVRADYTVTFGLPKPGLLLYPGA-EYAGEIFV 208
Cdd:PLN03049  167 VSVDIPSGWHVEEGDVNGEGLKPDMLVSLTAPKLCAKMFKGPhHFLGGRFV 217
PLN02918 PLN02918
pyridoxine (pyridoxamine) 5'-phosphate oxidase
 8-191 8.63e-16

pyridoxine (pyridoxamine) 5'-phosphate oxidase


Pssm-ID: 215496 [Multi-domain]  Cd Length: 544  Bit Score: 79.98  E-value: 8.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151   8 DIKRIDELASARYGVSHEILMENAGAAVARVVdmvAGVRNL----LVAVVAGTGNNGGDGLVAARHLASNGAEVRVFVVG 83
Cdd:PLN02918   95 EAAEIDETLMGPLGFSVDQLMELAGLSVAASI---AEVYKPgeysRVLAICGPGNNGGDGLVAARHLHHFGYKPFVCYPK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151  84 REDKmtDLARINLARVRSAGIPveFVSEENISELRSElEYsDVVVDALFGIGLN----KPVEGVYRK--AIEAVNSSG-- 155
Cdd:PLN02918  172 RTAK--PLYTGLVTQLESLSVP--FVSVEDLPADLSK-DF-DIIVDAMFGFSFHgaprPPFDDLIRRlvSLQNYEQTLkh 245

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1915720151 156 AIIVGVDIPSGVNGDTGQVMGVAVRADYTVTFGLPK 191
Cdd:PLN02918  246 PVIVSVDIPSGWHVEEGDHEGGGIKPDMLVSLTAPK 281
THZ_kinase cd01170
4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the ...
 303-486 2.71e-06

4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine and 1-deoxy-D-xylulose-5-phosphate.


Pssm-ID: 238575 [Multi-domain]  Cd Length: 242  Bit Score: 48.69  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 303 TANGTVAY-------ANLERLLKLAEWADIVVVGPG-LTTE-EETSRLVREVVARVDKPVVIDgdgLTAVSASPevLRKR 373
Cdd:cd01170    23 VANVLLAIgaspimsDAPEEVEELAKIAGALVINIGtLTSEqIEAMLKAGKAANQLGKPVVLD---PVGVGATS--FRTE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 374 S--------KPTVLTPHLGEMSRLTG-----VGVD---EIKQDRIGVLRRACRDLNSIIVLKGAHTLVGmpDG-RVYINL 436
Cdd:cd01170    98 VakellaegQPTVIRGNASEIAALAGltglgKGVDsssSDEEDALELAKALARKYGAVVVVTGEVDYIT--DGeRVVVVK 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1915720151 437 SGNPGMAK-AGSGDVLVGTIAAMYGLGFPIEVAVRMGVFVHGAAGDYVAAR 486
Cdd:cd01170   176 NGHPLLTKiTGTGCLLGAVIAAFLAVGDDPLEAAVSAVLVYGIAGELAAER 226
Phos_pyr_kin pfam08543
Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate ...
 331-478 1.36e-04

Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.


Pssm-ID: 430062 [Multi-domain]  Cd Length: 246  Bit Score: 43.62  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 331 GLTTEEETSRLVREVVARVDKPVVID-------GDGLTAVSAsPEVLRKRSKP--TVLTPHLGEMSRLTGVGVDEIKQdr 401
Cdd:pfam08543  67 GMLGSAEIIEAVAEKLDKYGVPVVLDpvmvaksGDSLLDDEA-IEALKEELLPlaTLITPNLPEAEALTGRKIKTLED-- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 402 igvLRRACRDLNSI----IVLKGAHTLVG--------MPDGRVYInLSGNPGMAKA--GSGDVLVGTIAAMYGLGFPIEV 467
Cdd:pfam08543 144 ---MKEAAKKLLALgakaVLIKGGHLEGEeavvtdvlYDGGGFYT-LEAPRIPTKNthGTGCTLSAAIAANLAKGLSLPE 219

                         170
                  ....*....|..
gi 1915720151 468 AVRMGV-FVHGA 478
Cdd:pfam08543 220 AVREAKeYVTEA 231
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 337-478 6.58e-03

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 38.48  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 337 ETSRLVREVVARVD-KPVVID-------GDGLTAVSASpEVLRKR--SKPTVLTPHLGEMSRLTGVGVDEIKQdrigvLR 406
Cdd:COG0351    79 EIIEAVAEILADYPlVPVVLDpvmvaksGDRLLDEDAV-EALRELllPLATVVTPNLPEAEALLGIEITTLDD-----MR 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915720151 407 RACRDLNSI----IVLKGAH--------TLVgmpDGRVYINLSGN--PGMAKAGSGDVLVGTIAAMYGLGFPIEVAVRMG 472
Cdd:COG0351   153 EAAKALLELgakaVLVKGGHlpgdeavdVLY---DGDGVREFSAPriDTGNTHGTGCTLSSAIAALLAKGLDLEEAVREA 229


                  ....*..
gi 1915720151 473 V-FVHGA 478
Cdd:COG0351   230 KeYVTQA 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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