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Conserved domains on  [gi|1906672232|ref|WP_189432473|]
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glutamate--cysteine ligase [Alishewanella longhuensis]

Protein Classification

glutamate--cysteine ligase( domain architecture ID 10006790)

glutamate--cysteine ligase catalyzes the conversion of ATP, L-glutamate, and L-cysteine to ADP, phosphate, and gamma-L-glutamyl-L-cysteine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GshA COG2918
Gamma-glutamylcysteine synthetase [Coenzyme transport and metabolism];
1-520 0e+00

Gamma-glutamylcysteine synthetase [Coenzyme transport and metabolism];


:

Pssm-ID: 442162  Cd Length: 518  Bit Score: 910.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232   1 MASSILQRLTALQQNGQTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDT 80
Cdd:COG2918     1 MSPDLSRRLAWLAAPAHPSLLKGILRGIERETLRVTPDGRLAQTPHPAALGSALTHPWITTDYSEALLEFITPVFDDIDE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  81 TLKQLADVHRFTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQS 160
Cdd:COG2918    81 LLAFLRDIHRFVYRHLGDELLWPLSMPCFLPGEEDIPIAQYGSSNIGRMKTVYRRGLKNRYGRLMQTIAGVHYNFSLPEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 161 FWQTYQAQLSVQGDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQSRyaFQSLGKGSLYLPYATSLRMS 240
Cdd:COG2918   161 FWQALQGLEGDSESLQDFISAGYFGLIRNFRRFGWLIPYLFGASPAVCKSFLKGREHP--LEEFDKGTLYLPYATSLRMS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 241 DLGYTNSAQSSLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTC 320
Cdd:COG2918   239 DLGYQNKAQSGLKICYNSLDSYVDSLRRAIRTPSPEYEKIGVKVDGEYRQLNTNILQIENEYYSPIRPKRVTRSGEKPSQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 321 ALAKRGVEYIEVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGRRSNLELLQDGQP 400
Cdd:COG2918   319 ALLRRGVEYIEVRSLDINPFSPIGIDEEQIRFLDLFLLWCLLADSPPISAEELAEIDDNFNRVVLEGRKPGLTLQRGGEE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 401 RLMQDWAEQLFADMMPVANYLDQAYGTERYQGALKHYYLSLLDPSQTLSGKVLNHLVSARKDNGSYMRELAEQYRQQLLQ 480
Cdd:COG2918   399 IPLQDWGKELLDDLQPVAELLDAAHGGGAYQAALAAQRAKLDDPELTPSARILAEMRENGEGFGEFGLRLAKQHREYLRA 478
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1906672232 481 EPYQFYTEQDFAAAVSESLQRQAEIEASDTLSFDEYIEQY 520
Cdd:COG2918   479 EPLSAETEAEFEAEAEESLAEQAEIEAADTLSFDEFLARY 518
 
Name Accession Description Interval E-value
GshA COG2918
Gamma-glutamylcysteine synthetase [Coenzyme transport and metabolism];
1-520 0e+00

Gamma-glutamylcysteine synthetase [Coenzyme transport and metabolism];


Pssm-ID: 442162  Cd Length: 518  Bit Score: 910.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232   1 MASSILQRLTALQQNGQTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDT 80
Cdd:COG2918     1 MSPDLSRRLAWLAAPAHPSLLKGILRGIERETLRVTPDGRLAQTPHPAALGSALTHPWITTDYSEALLEFITPVFDDIDE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  81 TLKQLADVHRFTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQS 160
Cdd:COG2918    81 LLAFLRDIHRFVYRHLGDELLWPLSMPCFLPGEEDIPIAQYGSSNIGRMKTVYRRGLKNRYGRLMQTIAGVHYNFSLPEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 161 FWQTYQAQLSVQGDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQSRyaFQSLGKGSLYLPYATSLRMS 240
Cdd:COG2918   161 FWQALQGLEGDSESLQDFISAGYFGLIRNFRRFGWLIPYLFGASPAVCKSFLKGREHP--LEEFDKGTLYLPYATSLRMS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 241 DLGYTNSAQSSLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTC 320
Cdd:COG2918   239 DLGYQNKAQSGLKICYNSLDSYVDSLRRAIRTPSPEYEKIGVKVDGEYRQLNTNILQIENEYYSPIRPKRVTRSGEKPSQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 321 ALAKRGVEYIEVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGRRSNLELLQDGQP 400
Cdd:COG2918   319 ALLRRGVEYIEVRSLDINPFSPIGIDEEQIRFLDLFLLWCLLADSPPISAEELAEIDDNFNRVVLEGRKPGLTLQRGGEE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 401 RLMQDWAEQLFADMMPVANYLDQAYGTERYQGALKHYYLSLLDPSQTLSGKVLNHLVSARKDNGSYMRELAEQYRQQLLQ 480
Cdd:COG2918   399 IPLQDWGKELLDDLQPVAELLDAAHGGGAYQAALAAQRAKLDDPELTPSARILAEMRENGEGFGEFGLRLAKQHREYLRA 478
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1906672232 481 EPYQFYTEQDFAAAVSESLQRQAEIEASDTLSFDEYIEQY 520
Cdd:COG2918   479 EPLSAETEAEFEAEAEESLAEQAEIEAADTLSFDEFLARY 518
Glu_cys_ligase pfam04262
Glutamate-cysteine ligase; Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that ...
11-383 0e+00

Glutamate-cysteine ligase; Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that carry out the first step of the glutathione biosynthesis pathway.


Pssm-ID: 427826  Cd Length: 371  Bit Score: 685.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  11 ALQQNGQTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDTTLKQLADVHR 90
Cdd:pfam04262   2 LLSDNPHLPLLKGILRGIERESLRVTPDGKLAQTPHPKALGSALTHPWITTDFSESLLEFITPPFSDVDETLDFLNDLHR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  91 FTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQSFWQTYQAQLS 170
Cdd:pfam04262  82 FVYRNLGDELLWPLSMPCVLPDEEDIPIAQYGTSNIGRMKTVYREGLAHRYGKKMQTIAGVHYNFSLPDSFWPLLQELEG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 171 VQgDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQsrYAFQSLGKGSLYLPYATSLRMSDLGYTNSAQS 250
Cdd:pfam04262 162 SE-LSQDFISDGYFGLIRNFYRYGWLLPYLFGASPALCSSFLKGRN--HPLEKLDAGTLYLPYATSLRMSDLGYTNKAQA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 251 SLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTCALAKRGVEYI 330
Cdd:pfam04262 239 SLKISYNSLDEYVKSLKKAISTPSPEYEKIGVKVDGEYRQLNTNVLQIENEFYSPIRPKRVTKSGERPLDALLRRGVEYI 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1906672232 331 EVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKV 383
Cdd:pfam04262 319 EVRSLDINPFSPLGIDEEQLRFLDLFLLYCLLEESPEIDEEELAEIRKNQERV 371
glu_cys_ligase TIGR01434
glutamate--cysteine ligase; Alternate name: gamma-glutamylcysteine synthetase. This model ...
7-520 0e+00

glutamate--cysteine ligase; Alternate name: gamma-glutamylcysteine synthetase. This model represents glutamate--cysteine ligase, and enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can serve to protect against oxidative damage and participate in a biosynthetic or detoxification reactions. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 213621  Cd Length: 512  Bit Score: 634.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232   7 QRLTALQQNgqTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDTTLKQLA 86
Cdd:TIGR01434   2 QALAWLEKN--PQALKGIQRGIERETLRVNADGTLATTGHPEALGSALTHKWITTDFSEALLEFITPTDGDIAHMLTFLR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  87 DVHRFTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQSFWQTYQ 166
Cdd:TIGR01434  80 DLHRFTASKLGDERMWPLSMPCYIADGQDIEIAQYGTSNIGRFKTLYREGLKNRYGALMQTISGIHYNFSLPMAFWQAKR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 167 AQLSVQgDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQSRYAFQSLGKGSLYLPYATSLRMSDLGYTN 246
Cdd:TIGR01434 160 GAEGGE-SAKDKISAGYFRLIRNYYRFGWVIPYLFGASPAISSSFLQGKPTKLPFEKTDEGMYYLPYATSLRLSDLGYTN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 247 SAQSSLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTCALAKRG 326
Cdd:TIGR01434 239 KSQSNLGITFNDLQEYIASLKQAIKTPSEEYAKIGTKKDGKRLQLNTNILQIENELYAPIRPKRVTRSGESPSDALLRRG 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 327 VEYIEVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGRRSNLEL--LQDGQPRLMQ 404
Cdd:TIGR01434 319 IEYVEVRSLDINPFSPIGIDEQQVRFLDLFLVWCALADSPEMSSGELLCTTDNWNRVILEGRKPGLTLgiGCETAQFPLP 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 405 DWAEQLFADMMPVANYLDQAYGTERYQGALKHYYLSLLDPSQTLSGKVLNHLVSarKDNGSYMRELAEQYRQQLLQEPYQ 484
Cdd:TIGR01434 399 VVGKDLFRDLKRVAQTLDSIRGGEAYQKACDELVACFDNPELTFSAQILRSMID--TGIGGTGLAFAEAYRELFREEPLE 476
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1906672232 485 FYTEQDFAAAVSESLQRQAEIEASDTLSFDEYIEQY 520
Cdd:TIGR01434 477 ILEQERFEAERSASLRRQQEIERADTEPFATWLAKH 512
PRK02471 PRK02471
bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;
27-485 3.46e-105

bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;


Pssm-ID: 179427 [Multi-domain]  Cd Length: 752  Bit Score: 331.89  E-value: 3.46e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  27 GIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDTTLKQLADVHRFTSRQL-ADERLWPAS 105
Cdd:PRK02471   22 GLEKESLRVDSDGKLALTPHPKAFGSRSFHPYIQTDFSESQLELITPVADSIEEVYRFLGALHDVASRSLdEDEYLWPLS 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 106 MPCYITDQQQIPLAYYGksnvGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQSFWQTYQAQLSVQGDLQEFISDQYLS 185
Cdd:PRK02471  102 MPPILPDEEEIPIAQLD----NREDVQYREYLAKKYGKKKQMISGIHYNFSLGEALIQRLFEEQSEQQDYKDFKNDLYLK 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 186 LIRNYKRYAWLIVYLFGASPAMCQSFLEGrQSRYAFQslgkgslylpYATSLRMSDLGYTNSaqSSLNITYNNLPEYIAG 265
Cdd:PRK02471  178 VARNFLRYRWLLTYLFGASPVAEADFFKQ-NKEYLNQ----------DVRSLRNSKYGYVNK--EDVYVSYNSLEDYVSS 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 266 LHAAVSQpsaeyqnigtkvagvyQQLNAnvlqiENEFYSTIRPKRTTESGErptcaLAKRGVEYIEVRALDVNPFSAIGI 345
Cdd:PRK02471  245 LENAVES----------------GQLIS-----EKEFYSPVRLRGAKQDRS-----LLEKGITYLEFRLFDLNPFEPYGI 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 346 TAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGrrsnlellqDGQPRLMQDWAEQLFADMMPVAnyldQAY 425
Cdd:PRK02471  299 SQETLDFVHLFLLYLLWLDEPEDTDQWVELADENNNLIALEH---------PLEALALAAEAELILDAMEDLV----QHL 365
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906672232 426 G-TERYQGALKHYYLSLLDPSQTLSGKVLNHLvsarkDNGSYMR---ELAEQYRQQLLQEPYQF 485
Cdd:PRK02471  366 GlPDEYQDLIKQLKEQLTDPEKTLSGRLLKQI-----KQESYVAfglEQAKQYKEYAWERPYAL 424
 
Name Accession Description Interval E-value
GshA COG2918
Gamma-glutamylcysteine synthetase [Coenzyme transport and metabolism];
1-520 0e+00

Gamma-glutamylcysteine synthetase [Coenzyme transport and metabolism];


Pssm-ID: 442162  Cd Length: 518  Bit Score: 910.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232   1 MASSILQRLTALQQNGQTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDT 80
Cdd:COG2918     1 MSPDLSRRLAWLAAPAHPSLLKGILRGIERETLRVTPDGRLAQTPHPAALGSALTHPWITTDYSEALLEFITPVFDDIDE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  81 TLKQLADVHRFTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQS 160
Cdd:COG2918    81 LLAFLRDIHRFVYRHLGDELLWPLSMPCFLPGEEDIPIAQYGSSNIGRMKTVYRRGLKNRYGRLMQTIAGVHYNFSLPEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 161 FWQTYQAQLSVQGDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQSRyaFQSLGKGSLYLPYATSLRMS 240
Cdd:COG2918   161 FWQALQGLEGDSESLQDFISAGYFGLIRNFRRFGWLIPYLFGASPAVCKSFLKGREHP--LEEFDKGTLYLPYATSLRMS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 241 DLGYTNSAQSSLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTC 320
Cdd:COG2918   239 DLGYQNKAQSGLKICYNSLDSYVDSLRRAIRTPSPEYEKIGVKVDGEYRQLNTNILQIENEYYSPIRPKRVTRSGEKPSQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 321 ALAKRGVEYIEVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGRRSNLELLQDGQP 400
Cdd:COG2918   319 ALLRRGVEYIEVRSLDINPFSPIGIDEEQIRFLDLFLLWCLLADSPPISAEELAEIDDNFNRVVLEGRKPGLTLQRGGEE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 401 RLMQDWAEQLFADMMPVANYLDQAYGTERYQGALKHYYLSLLDPSQTLSGKVLNHLVSARKDNGSYMRELAEQYRQQLLQ 480
Cdd:COG2918   399 IPLQDWGKELLDDLQPVAELLDAAHGGGAYQAALAAQRAKLDDPELTPSARILAEMRENGEGFGEFGLRLAKQHREYLRA 478
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1906672232 481 EPYQFYTEQDFAAAVSESLQRQAEIEASDTLSFDEYIEQY 520
Cdd:COG2918   479 EPLSAETEAEFEAEAEESLAEQAEIEAADTLSFDEFLARY 518
Glu_cys_ligase pfam04262
Glutamate-cysteine ligase; Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that ...
11-383 0e+00

Glutamate-cysteine ligase; Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that carry out the first step of the glutathione biosynthesis pathway.


Pssm-ID: 427826  Cd Length: 371  Bit Score: 685.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  11 ALQQNGQTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDTTLKQLADVHR 90
Cdd:pfam04262   2 LLSDNPHLPLLKGILRGIERESLRVTPDGKLAQTPHPKALGSALTHPWITTDFSESLLEFITPPFSDVDETLDFLNDLHR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  91 FTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQSFWQTYQAQLS 170
Cdd:pfam04262  82 FVYRNLGDELLWPLSMPCVLPDEEDIPIAQYGTSNIGRMKTVYREGLAHRYGKKMQTIAGVHYNFSLPDSFWPLLQELEG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 171 VQgDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQsrYAFQSLGKGSLYLPYATSLRMSDLGYTNSAQS 250
Cdd:pfam04262 162 SE-LSQDFISDGYFGLIRNFYRYGWLLPYLFGASPALCSSFLKGRN--HPLEKLDAGTLYLPYATSLRMSDLGYTNKAQA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 251 SLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTCALAKRGVEYI 330
Cdd:pfam04262 239 SLKISYNSLDEYVKSLKKAISTPSPEYEKIGVKVDGEYRQLNTNVLQIENEFYSPIRPKRVTKSGERPLDALLRRGVEYI 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1906672232 331 EVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKV 383
Cdd:pfam04262 319 EVRSLDINPFSPLGIDEEQLRFLDLFLLYCLLEESPEIDEEELAEIRKNQERV 371
glu_cys_ligase TIGR01434
glutamate--cysteine ligase; Alternate name: gamma-glutamylcysteine synthetase. This model ...
7-520 0e+00

glutamate--cysteine ligase; Alternate name: gamma-glutamylcysteine synthetase. This model represents glutamate--cysteine ligase, and enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can serve to protect against oxidative damage and participate in a biosynthetic or detoxification reactions. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 213621  Cd Length: 512  Bit Score: 634.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232   7 QRLTALQQNgqTQSIVGIKRGIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDTTLKQLA 86
Cdd:TIGR01434   2 QALAWLEKN--PQALKGIQRGIERETLRVNADGTLATTGHPEALGSALTHKWITTDFSEALLEFITPTDGDIAHMLTFLR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  87 DVHRFTSRQLADERLWPASMPCYITDQQQIPLAYYGKSNVGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQSFWQTYQ 166
Cdd:TIGR01434  80 DLHRFTASKLGDERMWPLSMPCYIADGQDIEIAQYGTSNIGRFKTLYREGLKNRYGALMQTISGIHYNFSLPMAFWQAKR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 167 AQLSVQgDLQEFISDQYLSLIRNYKRYAWLIVYLFGASPAMCQSFLEGRQSRYAFQSLGKGSLYLPYATSLRMSDLGYTN 246
Cdd:TIGR01434 160 GAEGGE-SAKDKISAGYFRLIRNYYRFGWVIPYLFGASPAISSSFLQGKPTKLPFEKTDEGMYYLPYATSLRLSDLGYTN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 247 SAQSSLNITYNNLPEYIAGLHAAVSQPSAEYQNIGTKVAGVYQQLNANVLQIENEFYSTIRPKRTTESGERPTCALAKRG 326
Cdd:TIGR01434 239 KSQSNLGITFNDLQEYIASLKQAIKTPSEEYAKIGTKKDGKRLQLNTNILQIENELYAPIRPKRVTRSGESPSDALLRRG 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 327 VEYIEVRALDVNPFSAIGITAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGRRSNLEL--LQDGQPRLMQ 404
Cdd:TIGR01434 319 IEYVEVRSLDINPFSPIGIDEQQVRFLDLFLVWCALADSPEMSSGELLCTTDNWNRVILEGRKPGLTLgiGCETAQFPLP 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 405 DWAEQLFADMMPVANYLDQAYGTERYQGALKHYYLSLLDPSQTLSGKVLNHLVSarKDNGSYMRELAEQYRQQLLQEPYQ 484
Cdd:TIGR01434 399 VVGKDLFRDLKRVAQTLDSIRGGEAYQKACDELVACFDNPELTFSAQILRSMID--TGIGGTGLAFAEAYRELFREEPLE 476
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1906672232 485 FYTEQDFAAAVSESLQRQAEIEASDTLSFDEYIEQY 520
Cdd:TIGR01434 477 ILEQERFEAERSASLRRQQEIERADTEPFATWLAKH 512
PRK02471 PRK02471
bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;
27-485 3.46e-105

bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;


Pssm-ID: 179427 [Multi-domain]  Cd Length: 752  Bit Score: 331.89  E-value: 3.46e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232  27 GIERETLRVNADGTLAQSAHPLALGSALTHPWITTDFSESLLEFITPASADIDTTLKQLADVHRFTSRQL-ADERLWPAS 105
Cdd:PRK02471   22 GLEKESLRVDSDGKLALTPHPKAFGSRSFHPYIQTDFSESQLELITPVADSIEEVYRFLGALHDVASRSLdEDEYLWPLS 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 106 MPCYITDQQQIPLAYYGksnvGRMKTLYRQGLKNRYGSMMQAISGVHFNFSLPQSFWQTYQAQLSVQGDLQEFISDQYLS 185
Cdd:PRK02471  102 MPPILPDEEEIPIAQLD----NREDVQYREYLAKKYGKKKQMISGIHYNFSLGEALIQRLFEEQSEQQDYKDFKNDLYLK 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 186 LIRNYKRYAWLIVYLFGASPAMCQSFLEGrQSRYAFQslgkgslylpYATSLRMSDLGYTNSaqSSLNITYNNLPEYIAG 265
Cdd:PRK02471  178 VARNFLRYRWLLTYLFGASPVAEADFFKQ-NKEYLNQ----------DVRSLRNSKYGYVNK--EDVYVSYNSLEDYVSS 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 266 LHAAVSQpsaeyqnigtkvagvyQQLNAnvlqiENEFYSTIRPKRTTESGErptcaLAKRGVEYIEVRALDVNPFSAIGI 345
Cdd:PRK02471  245 LENAVES----------------GQLIS-----EKEFYSPVRLRGAKQDRS-----LLEKGITYLEFRLFDLNPFEPYGI 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906672232 346 TAEQMHFLDIFLVYCLLEQSPALSAAEQSITEQNLKKVVTDGrrsnlellqDGQPRLMQDWAEQLFADMMPVAnyldQAY 425
Cdd:PRK02471  299 SQETLDFVHLFLLYLLWLDEPEDTDQWVELADENNNLIALEH---------PLEALALAAEAELILDAMEDLV----QHL 365
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906672232 426 G-TERYQGALKHYYLSLLDPSQTLSGKVLNHLvsarkDNGSYMR---ELAEQYRQQLLQEPYQF 485
Cdd:PRK02471  366 GlPDEYQDLIKQLKEQLTDPEKTLSGRLLKQI-----KQESYVAfglEQAKQYKEYAWERPYAL 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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