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Conserved domains on  [gi|1897049179|ref|WP_186975273|]
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MULTISPECIES: crossover junction endodeoxyribonuclease RuvC [Butyricimonas]

Protein Classification

crossover junction endodeoxyribonuclease RuvC( domain architecture ID 10002778)

crossover junction endodeoxyribonuclease RuvC catalyzes endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)

CATH:  3.30.420.140
EC:  3.1.21.10
Gene Ontology:  GO:0003677|GO:0000287|GO:0008821|GO:0006281|GO:0006310|GO:0048476
SCOP:  4000553

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RuvC COG0817
Holliday junction resolvasome RuvABC endonuclease subunit RuvC [Replication, recombination and ...
 5-156 1.40e-64

Holliday junction resolvasome RuvABC endonuclease subunit RuvC [Replication, recombination and repair];


:

Pssm-ID: 440579  Cd Length: 152  Bit Score: 195.30  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGknSRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:COG0817     1 ILGIDPGLRRTGYGVIEVDG--NRLRLVASGVIRTPPKLPLPERLLEIYEGLTELIEEYKPDEVAIEEVFFNKNPKSALK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMVM-----PDTISTLDETDAIAIAYCHH 156
Cdd:COG0817    79 LGQARGVALLAAAQRGLPVAEYTPLQVKKAVTGYGRADKEQVQ-----AMVKrllglDEIPKPDDAADALAIAICHA 150
 
Name Accession Description Interval E-value
RuvC COG0817
Holliday junction resolvasome RuvABC endonuclease subunit RuvC [Replication, recombination and ...
 5-156 1.40e-64

Holliday junction resolvasome RuvABC endonuclease subunit RuvC [Replication, recombination and repair];


Pssm-ID: 440579  Cd Length: 152  Bit Score: 195.30  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGknSRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:COG0817     1 ILGIDPGLRRTGYGVIEVDG--NRLRLVASGVIRTPPKLPLPERLLEIYEGLTELIEEYKPDEVAIEEVFFNKNPKSALK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMVM-----PDTISTLDETDAIAIAYCHH 156
Cdd:COG0817    79 LGQARGVALLAAAQRGLPVAEYTPLQVKKAVTGYGRADKEQVQ-----AMVKrllglDEIPKPDDAADALAIAICHA 150
ruvC PRK00039
Holliday junction resolvase; Reviewed
 2-155 3.42e-62

Holliday junction resolvase; Reviewed


Pssm-ID: 234587  Cd Length: 164  Bit Score: 189.56  E-value: 3.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   2 EKLIMGIDPGTNFMGYAILRTTGKnsRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQS 81
Cdd:PRK00039    1 MMRILGIDPGLRRTGYGVIEVEGR--RLSYVASGVIRTPSDLDLPERLKQIYDGLSELIDEYQPDEVAIEEVFFNKNPQS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1897049179  82 MLKLGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMVM-----PDTISTLDETDAIAIAYCH 155
Cdd:PRK00039   79 ALKLGQARGVAILAAAQRGLPVAEYTPLQVKKAVVGYGRADKEQVQ-----HMVKrllnlPEIPKPDDAADALAIAICH 152
RuvC cd16962
Crossover junction endodeoxyribonuclease RuvC; Crossover junction endodeoxyribonuclease RuvC ...
 5-156 2.42e-58

Crossover junction endodeoxyribonuclease RuvC; Crossover junction endodeoxyribonuclease RuvC is also called Holliday junction resolvase RuvC. It is part of the RuvABC pathway in Escherichia coli and other Gram-negative bacteria that is involved in processing Holliday junctions, which are formed by the reciprocal exchange of strands between two DNA duplexes. Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. RuvC is thought to bind either on the open, DNA exposed face of a single RuvA tetramer, or to replace one of the two tetramers. Binding is proposed to be mediated by an unstructured loop on RuvC, which becomes structured on binding RuvA. RuvC can be bound to the complex in either orientation, therefore resolving Holliday junctions in either a horizontal or vertical manner. HJRs occur in archaea, bacteria, and in the mitochondria of certain fungi. These are referred to as the RuvC family of Holliday junction resolvases, RuvC being the Escherichia coli HJR. RuvC and its orthologs are homodimers and display structural similarity to RNase H and Hsp70.


Pssm-ID: 438562  Cd Length: 152  Bit Score: 179.55  E-value: 2.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRttGKNSRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:cd16962     1 ILGIDPGLRRTGYGVIE--VEGNKLRLLDYGVIRTPSKLSLPERLKEIYDGLSELIEKYKPDEVAIEKLFFNKNPKSALK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMV-----MPDTISTLDETDAIAIAYCHH 156
Cdd:cd16962    79 LGQARGVILLAAAQAGLPVVEYTPRQVKQAVTGYGRADKEQVQ-----YMVkrllgLKEIPKPDDAADALAIALCHA 150
RuvC pfam02075
Crossover junction endodeoxyribonuclease RuvC; This entry includes endodeoxyribonucleases ...
 5-155 2.31e-41

Crossover junction endodeoxyribonuclease RuvC; This entry includes endodeoxyribonucleases found in bacteria, such as RuvC. RuvC is a small protein of about 20 kD. It requires and binds a magnesium ion. The structure of E. coli RuvC is a 3-layer alpha-beta sandwich containing a 5-stranded beta-sheet sandwiched between 5 alpha-helices. The Escherichia coli RuvC gene is involved in DNA repair and in the late step of RecE and RecF pathway recombination. RuvC protein (EC:3.1.22.4) cleaves cruciform junctions, which are formed by the extrusion of inverted repeat sequences from a super-coiled plasmid and which are structurally analogous to Holliday junctions, by introducing nicks into strands with the same polarity. The nicks leave a 5'terminal phosphate and a 3'terminal hydroxyl group which are ligated by E. coli or Bacteriophage T4 DNA ligases. Analysis of the cleavage sites suggests that DNA topology rather than a particular sequence determines the cleavage site. RuvC protein also cleaves Holliday junctions that are formed between gapped circular and linear duplex DNA by the function of RecA protein. The active form of RuvC protein is a dimer. This is mechanistically suited for an endonuclease involved in swapping DNA strands at the crossover junctions. It is inferred that RuvC protein is an endonuclease that resolves Holliday structures in vivo.


Pssm-ID: 366907  Cd Length: 148  Bit Score: 136.43  E-value: 2.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGknSRPELVVSGVVDMKKlDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:pfam02075   1 ILGIDPGSRKTGYGVIEHAG--RQLSYLTSGVIRTTS-DPLQERLLDVFDAVDEVIDRYQPDYVAIEQVFFAKNVDSALK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAILLGKFMVMPDTISTLDETDAIAIAYCH 155
Cdd:pfam02075  78 LAQARGVAILAAAERGISVAEYTPSQVKKAVTGNGKAEKEQVQHMVKRLLNLTAKPQPADAADALAVAITH 148
ruvC TIGR00228
crossover junction endodeoxyribonuclease RuvC; Endonuclease that resolves Holliday junction ...
 5-161 6.61e-38

crossover junction endodeoxyribonuclease RuvC; Endonuclease that resolves Holliday junction intermediates in genetic recombination. The active form of the protein is a dimer. Structure studies reveals that the catalytic center, comprised of four acidic residues, lies at the bottom of a cleft that fits a DNA duplex. The model hits a single Synechocystis PCC6803 protein at a score of 30, below the trusted cutoff, that appears orthologous and may act as authentic RuvC. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129331  Cd Length: 156  Bit Score: 127.74  E-value: 6.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGKnsRPELVVSGVVDMKKLDDPYlKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:TIGR00228   1 ILGIDPGSRVTGYGVIRQVGR--QLSYLGSGCIRTKVDDLPS-RLKLIYAGVTEIITQFQPNYFAIEQVFMAKNADSALK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAILLGKFMVMPDTIStLDETDAIAIA--YCHHIQGNL 161
Cdd:TIGR00228  78 LGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRRLLKLPANPQ-ADAADALAIAitHAHVSQNAL 155
 
Name Accession Description Interval E-value
RuvC COG0817
Holliday junction resolvasome RuvABC endonuclease subunit RuvC [Replication, recombination and ...
 5-156 1.40e-64

Holliday junction resolvasome RuvABC endonuclease subunit RuvC [Replication, recombination and repair];


Pssm-ID: 440579  Cd Length: 152  Bit Score: 195.30  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGknSRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:COG0817     1 ILGIDPGLRRTGYGVIEVDG--NRLRLVASGVIRTPPKLPLPERLLEIYEGLTELIEEYKPDEVAIEEVFFNKNPKSALK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMVM-----PDTISTLDETDAIAIAYCHH 156
Cdd:COG0817    79 LGQARGVALLAAAQRGLPVAEYTPLQVKKAVTGYGRADKEQVQ-----AMVKrllglDEIPKPDDAADALAIAICHA 150
ruvC PRK00039
Holliday junction resolvase; Reviewed
 2-155 3.42e-62

Holliday junction resolvase; Reviewed


Pssm-ID: 234587  Cd Length: 164  Bit Score: 189.56  E-value: 3.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   2 EKLIMGIDPGTNFMGYAILRTTGKnsRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQS 81
Cdd:PRK00039    1 MMRILGIDPGLRRTGYGVIEVEGR--RLSYVASGVIRTPSDLDLPERLKQIYDGLSELIDEYQPDEVAIEEVFFNKNPQS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1897049179  82 MLKLGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMVM-----PDTISTLDETDAIAIAYCH 155
Cdd:PRK00039   79 ALKLGQARGVAILAAAQRGLPVAEYTPLQVKKAVVGYGRADKEQVQ-----HMVKrllnlPEIPKPDDAADALAIAICH 152
RuvC cd16962
Crossover junction endodeoxyribonuclease RuvC; Crossover junction endodeoxyribonuclease RuvC ...
 5-156 2.42e-58

Crossover junction endodeoxyribonuclease RuvC; Crossover junction endodeoxyribonuclease RuvC is also called Holliday junction resolvase RuvC. It is part of the RuvABC pathway in Escherichia coli and other Gram-negative bacteria that is involved in processing Holliday junctions, which are formed by the reciprocal exchange of strands between two DNA duplexes. Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. RuvC is thought to bind either on the open, DNA exposed face of a single RuvA tetramer, or to replace one of the two tetramers. Binding is proposed to be mediated by an unstructured loop on RuvC, which becomes structured on binding RuvA. RuvC can be bound to the complex in either orientation, therefore resolving Holliday junctions in either a horizontal or vertical manner. HJRs occur in archaea, bacteria, and in the mitochondria of certain fungi. These are referred to as the RuvC family of Holliday junction resolvases, RuvC being the Escherichia coli HJR. RuvC and its orthologs are homodimers and display structural similarity to RNase H and Hsp70.


Pssm-ID: 438562  Cd Length: 152  Bit Score: 179.55  E-value: 2.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRttGKNSRPELVVSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:cd16962     1 ILGIDPGLRRTGYGVIE--VEGNKLRLLDYGVIRTPSKLSLPERLKEIYDGLSELIEKYKPDEVAIEKLFFNKNPKSALK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAillgkFMV-----MPDTISTLDETDAIAIAYCHH 156
Cdd:cd16962    79 LGQARGVILLAAAQAGLPVVEYTPRQVKQAVTGYGRADKEQVQ-----YMVkrllgLKEIPKPDDAADALAIALCHA 150
RuvC pfam02075
Crossover junction endodeoxyribonuclease RuvC; This entry includes endodeoxyribonucleases ...
 5-155 2.31e-41

Crossover junction endodeoxyribonuclease RuvC; This entry includes endodeoxyribonucleases found in bacteria, such as RuvC. RuvC is a small protein of about 20 kD. It requires and binds a magnesium ion. The structure of E. coli RuvC is a 3-layer alpha-beta sandwich containing a 5-stranded beta-sheet sandwiched between 5 alpha-helices. The Escherichia coli RuvC gene is involved in DNA repair and in the late step of RecE and RecF pathway recombination. RuvC protein (EC:3.1.22.4) cleaves cruciform junctions, which are formed by the extrusion of inverted repeat sequences from a super-coiled plasmid and which are structurally analogous to Holliday junctions, by introducing nicks into strands with the same polarity. The nicks leave a 5'terminal phosphate and a 3'terminal hydroxyl group which are ligated by E. coli or Bacteriophage T4 DNA ligases. Analysis of the cleavage sites suggests that DNA topology rather than a particular sequence determines the cleavage site. RuvC protein also cleaves Holliday junctions that are formed between gapped circular and linear duplex DNA by the function of RecA protein. The active form of RuvC protein is a dimer. This is mechanistically suited for an endonuclease involved in swapping DNA strands at the crossover junctions. It is inferred that RuvC protein is an endonuclease that resolves Holliday structures in vivo.


Pssm-ID: 366907  Cd Length: 148  Bit Score: 136.43  E-value: 2.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGknSRPELVVSGVVDMKKlDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:pfam02075   1 ILGIDPGSRKTGYGVIEHAG--RQLSYLTSGVIRTTS-DPLQERLLDVFDAVDEVIDRYQPDYVAIEQVFFAKNVDSALK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAILLGKFMVMPDTISTLDETDAIAIAYCH 155
Cdd:pfam02075  78 LAQARGVAILAAAERGISVAEYTPSQVKKAVTGNGKAEKEQVQHMVKRLLNLTAKPQPADAADALAVAITH 148
ruvC TIGR00228
crossover junction endodeoxyribonuclease RuvC; Endonuclease that resolves Holliday junction ...
 5-161 6.61e-38

crossover junction endodeoxyribonuclease RuvC; Endonuclease that resolves Holliday junction intermediates in genetic recombination. The active form of the protein is a dimer. Structure studies reveals that the catalytic center, comprised of four acidic residues, lies at the bottom of a cleft that fits a DNA duplex. The model hits a single Synechocystis PCC6803 protein at a score of 30, below the trusted cutoff, that appears orthologous and may act as authentic RuvC. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129331  Cd Length: 156  Bit Score: 127.74  E-value: 6.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGKnsRPELVVSGVVDMKKLDDPYlKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:TIGR00228   1 ILGIDPGSRVTGYGVIRQVGR--QLSYLGSGCIRTKVDDLPS-RLKLIYAGVTEIITQFQPNYFAIEQVFMAKNADSALK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYAPKKIKMSITGTGEASKEQIAILLGKFMVMPDTIStLDETDAIAIA--YCHHIQGNL 161
Cdd:TIGR00228  78 LGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRRLLKLPANPQ-ADAADALAIAitHAHVSQNAL 155
RuvC-like cd00529
Crossover junction endodeoxyribonuclease RuvC and similar proteins; The RuvC-like family ...
 5-107 3.95e-14

Crossover junction endodeoxyribonuclease RuvC and similar proteins; The RuvC-like family consists of bacterial RuvC, fungal Cruciform cutting endonuclease 1 (CCE1), bacterial YqgF and monokaryotic chloroplast 1 protein (MOC1). RuvC, CCE1 and MOC1 are Holliday junction resolvases (HJRs), endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. RuvC is part of the RuvABC pathway in Escherichia coli and other Gram-negative bacteria that is involved in processing Holliday junctions, which are formed by the reciprocal exchange of strands between two DNA duplexes. CCE1 is a HJR specific for 4-way junctions; it is involved in the maintenance of mitochondrial DNA. Escherichia coli YqgF has been shown to act as a pre-16S rRNA nuclease, presumably as a monomer. It is involved in the processing of pre-16S rRNA during ribosome maturation. HJRs occur in archaea, bacteria, and in the mitochondria of certain fungi. RuvC and its orthologs are homodimers and display structural similarity to RNase H and Hsp70.


Pssm-ID: 438561  Cd Length: 110  Bit Score: 65.13  E-value: 3.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNFMGYAILRTTGKNSRPelvvSGVVDMKKLDDPYLKLQRVFQRTLQVIDSYHPDELAIESQFYGKNIQSMLK 84
Cdd:cd00529     1 VLGIDPGTKSLGLAVLSQNGVTALQ----VEVIKTLEVLVGPSRGRLDAARIVELLKEFQPDTIAVEQQFNYPGTGGALR 76

                          90       100
                  ....*....|....*....|...
gi 1897049179  85 LGRAQGVAIAAALQRNIPIFEYA 107
Cdd:cd00529    77 VGFARGMAIVIHVASGVPVVLYD 99
MOC1 cd22992
Monokaryotic chloroplast 1 protein (MOC1) and similar proteins; Monokaryotic chloroplast 1 ...
 5-130 4.69e-04

Monokaryotic chloroplast 1 protein (MOC1) and similar proteins; Monokaryotic chloroplast 1 protein (MOC1) is a Holliday junction (HJ) resolvase, originally identified from the green algae Chlamydomonas reinhardtii, but was later shown to be genetically conserved among green plants, such as Arabidopsis thaliana and Zea mays. Nicotiana tabacum MOC1 (NtMOC1) is exclusively localized to chloroplasts, and is essential for chloroplast nucleoid segregation. Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. NtMOC1 cleaves only four-way junctions and specifically introduces nicks between two cytosines at the homology core. NtMOC1 has the highest structural similarity to RuvC resolvase, suggesting their potentially similar HJ binding and resolution activities. However, the molecular basis for specific HJ resolution by MOC1 remains elusive. This family also includes bacterial homologs.


Pssm-ID: 438565  Cd Length: 151  Bit Score: 38.66  E-value: 4.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897049179   5 IMGIDPGTNfmG-YAILRTTGKNSRpelvvsgVVDMKKLDDPYLKLQRVFQRTLQVIDSY--HPDELAIESQ--FYGKNI 79
Cdd:cd22992     1 IIGIDPGLS--GaIAVLDPDGGLIE-------VFDMPTLKVGVGGRRVDAAALADLLRELapEPTLAVIEKVgaMPGQGV 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1897049179  80 QSMLKLGRAQGVAIAAALQRNIPIFEYAPKKIK--MSITGTG-EASKeQIAILL 130
Cdd:cd22992    72 QSAFSFGRSYGVIEGVLAALGIPVTLVTPQTWKkaFGLSGKDkDASR-ALARRL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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