NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1897043662|ref|WP_186970985|]
View 

MULTISPECIES: sensor histidine kinase [Blautia]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
277-594 5.01e-73

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 241.08  E-value: 5.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 277 NGWYHVTEIPGSYIRKNTQILLKTLVFTLLVSLPLTVLVIIMISGNLTKRLKRLSLAMESFHLGKNTPSPVpelvsaaks 356
Cdd:COG2972   135 LGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV--------- 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 357 pSSYDEIDRLGITFQNMQASLNQNMDSILELSLSEERLKYQLLQSQINPHFLYNILGSIKTCISLDRLKTADEMITDLTR 436
Cdd:COG2972   206 -SGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSK 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 437 FYRLTLRKSGDLIAIRDELEIARLYLEMEKLCHGDSLSWEIRAEDGIQNFLICRFTLQPFLENSIQHGISRQTPCVHISL 516
Cdd:COG2972   285 LLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRI 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1897043662 517 DVSYGDDTVIITITDNGAGIAPRQLEDLRATLENRTVDyqKHFGIGNVNKRLSSPSFDNGTVRVDSRLNEGTEIVITF 594
Cdd:COG2972   365 SIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEG--RGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRI 440
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
277-594 5.01e-73

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 241.08  E-value: 5.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 277 NGWYHVTEIPGSYIRKNTQILLKTLVFTLLVSLPLTVLVIIMISGNLTKRLKRLSLAMESFHLGKNTPSPVpelvsaaks 356
Cdd:COG2972   135 LGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV--------- 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 357 pSSYDEIDRLGITFQNMQASLNQNMDSILELSLSEERLKYQLLQSQINPHFLYNILGSIKTCISLDRLKTADEMITDLTR 436
Cdd:COG2972   206 -SGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSK 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 437 FYRLTLRKSGDLIAIRDELEIARLYLEMEKLCHGDSLSWEIRAEDGIQNFLICRFTLQPFLENSIQHGISRQTPCVHISL 516
Cdd:COG2972   285 LLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRI 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1897043662 517 DVSYGDDTVIITITDNGAGIAPRQLEDLRATLENRTVDyqKHFGIGNVNKRLSSPSFDNGTVRVDSRLNEGTEIVITF 594
Cdd:COG2972   365 SIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEG--RGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRI 440
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 394-473 2.68e-22

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 90.96  E-value: 2.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 394 LKYQLLQSQINPHFLYNILGSIKTCISLDRlKTADEMITDLTRFYRLTLRKSGDLIAIRDELEIARLYLEMEKLCHGDSL 473
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDP-EEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 488-593 6.14e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 70.94  E-value: 6.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 488 ICRFTLQPFLENSIQHGIS-RQTPCVhISLDVSYGDDTVIITITDNGAGIAPRQLEDLRATLENRTvdyqkhfGIG--NV 564
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSpLTDKGV-VTISALKEDNHVMIEVEDNGRGIDPKVLNILGKKPKEGN-------GIGlyNV 72

                          90       100
                  ....*....|....*....|....*....
gi 1897043662 565 NKRLSSPSFDNGTVRVDSRLNEGTEIVIT 593
Cdd:cd16924    73 HQRLILLFGEDYGIHIASEPDKGTRITFT 101
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 493-594 5.33e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 56.89  E-value: 5.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662  493 LQPFLENSIQHGisrqTPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEDL--RATLENRTVDYQKHFGIG--NVNKRL 568
Cdd:smart00387  10 LSNLLDNAIKYT----PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfePFFRTDKRSRKIGGTGLGlsIVKKLV 85

                           90       100
                   ....*....|....*....|....*.
gi 1897043662  569 SspSFdNGTVRVDSRLNEGTEIVITF 594
Cdd:smart00387  86 E--LH-GGEISVESEPGGGTTFTITL 108
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
522-602 9.95e-03

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 38.68  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 522 DDTVIITITDNGAGIAPrqledlratLENRtvdyQKHFGIGNVNKRLSSPsfdNGTVRVDSRLNEGTEIVITFEQMEDSD 601
Cdd:PRK10935  501 DGEHTVSIRDDGIGIGE---------LKEP----EGHYGLNIMQERAERL---GGTLTISQPPGGGTTVSLTFPSQQEPE 564


                  .
gi 1897043662 602 E 602
Cdd:PRK10935  565 S 565
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
277-594 5.01e-73

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 241.08  E-value: 5.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 277 NGWYHVTEIPGSYIRKNTQILLKTLVFTLLVSLPLTVLVIIMISGNLTKRLKRLSLAMESFHLGKNTPSPVpelvsaaks 356
Cdd:COG2972   135 LGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV--------- 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 357 pSSYDEIDRLGITFQNMQASLNQNMDSILELSLSEERLKYQLLQSQINPHFLYNILGSIKTCISLDRLKTADEMITDLTR 436
Cdd:COG2972   206 -SGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSK 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 437 FYRLTLRKSGDLIAIRDELEIARLYLEMEKLCHGDSLSWEIRAEDGIQNFLICRFTLQPFLENSIQHGISRQTPCVHISL 516
Cdd:COG2972   285 LLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRI 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1897043662 517 DVSYGDDTVIITITDNGAGIAPRQLEDLRATLENRTVDyqKHFGIGNVNKRLSSPSFDNGTVRVDSRLNEGTEIVITF 594
Cdd:COG2972   365 SIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEG--RGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRI 440
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
268-594 5.00e-42

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 155.03  E-value: 5.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 268 INYHTARLDNGWYHVTEIPGSYIRKNTQILLKTLVFTLLVSLPLTVLVIIMISGNLTKRLKRLSLAMESFHLGKNTPSPV 347
Cdd:COG3275    33 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 348 PELVSAAKSPSSYDEIDRLGITFQNMQASLNQNMDSILELSLSEERLKYQLLQSQINPHFLYNILGSIKTCISLDRlKTA 427
Cdd:COG3275   113 LLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDP-EKA 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 428 DEMITDLTRFYRLTLRKS-GDLIAIRDELEIARLYLEMEKLCHGDSLSWEIRAEDGIQNFLICRFTLQPFLENSIQHGIS 506
Cdd:COG3275   192 RELLLKLSDLLRYSLYESdKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGIS 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 507 RQTPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEDlratlenrtvdyQKHFGIGNVNKRLSSPSFDNGTVRVDSRLNE 586
Cdd:COG3275   272 SKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKKK------------GSGIGLKNVRERLELLYGDKYSLEIESTDGG 339


                  ....*...
gi 1897043662 587 GTEIVITF 594
Cdd:COG3275   340 GTKVTLKI 347
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 394-473 2.68e-22

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 90.96  E-value: 2.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 394 LKYQLLQSQINPHFLYNILGSIKTCISLDRlKTADEMITDLTRFYRLTLRKSGDLIAIRDELEIARLYLEMEKLCHGDSL 473
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDP-EEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 488-593 6.14e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 70.94  E-value: 6.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 488 ICRFTLQPFLENSIQHGIS-RQTPCVhISLDVSYGDDTVIITITDNGAGIAPRQLEDLRATLENRTvdyqkhfGIG--NV 564
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSpLTDKGV-VTISALKEDNHVMIEVEDNGRGIDPKVLNILGKKPKEGN-------GIGlyNV 72

                          90       100
                  ....*....|....*....|....*....
gi 1897043662 565 NKRLSSPSFDNGTVRVDSRLNEGTEIVIT 593
Cdd:cd16924    73 HQRLILLFGEDYGIHIASEPDKGTRITFT 101
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-592 1.83e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 60.94  E-value: 1.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 493 LQPFLENSIQHGISRQTPCVHISLDVS-YGDDTVIITITDNGAGIAPRQLEDLRATLENRTvdyqkHFGIGNVNKRLSsp 571
Cdd:cd16955     6 IQPLVENAIVHGIQEKKGKGVVKISVKkQLKNRLHIAVEDNGIGISPKVIERVEQDEMPGN-----KIGLLNVHQRLK-- 78

                          90       100
                  ....*....|....*....|.
gi 1897043662 572 SFDNGTVRVDSRLNEGTEIVI 592
Cdd:cd16955    79 LGYGEGLHIRSRPDPGTLIAF 99
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 493-594 5.33e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 56.89  E-value: 5.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662  493 LQPFLENSIQHGisrqTPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEDL--RATLENRTVDYQKHFGIG--NVNKRL 568
Cdd:smart00387  10 LSNLLDNAIKYT----PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfePFFRTDKRSRKIGGTGLGlsIVKKLV 85

                           90       100
                   ....*....|....*....|....*.
gi 1897043662  569 SspSFdNGTVRVDSRLNEGTEIVITF 594
Cdd:smart00387  86 E--LH-GGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 493-594 2.11e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 55.07  E-value: 2.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 493 LQPFLENSIQHgisrQTPCVHISLDVSYGDDtVIITITDNGAGIAPRQLEDLRATLENRTVDYQKHFGIG--NVNKRLSS 570
Cdd:pfam02518  10 LSNLLDNALKH----AAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGlsIVRKLVEL 84

                          90       100
                  ....*....|....*....|....
gi 1897043662 571 PsfdNGTVRVDSRLNEGTEIVITF 594
Cdd:pfam02518  85 L---GGTITVESEPGGGTTVTLTL 105
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 491-592 5.95e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 53.59  E-value: 5.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 491 FTLQPFLENSIQHGISRQTPCVHISLDVSYGDDTVIITITDNGAGIAPrqledlrATLENRTVDYQKHFGIGNVNKRLSS 570
Cdd:cd16956     4 LTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDP-------DTLARILIRSSNGLGLNLVDKRLRQ 76

                          90       100
                  ....*....|....*....|..
gi 1897043662 571 PSFDNGTVRVDSRLNEGTEIVI 592
Cdd:cd16956    77 AFGNDYGLDIECAPGEGTRITI 98
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
497-594 1.41e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 53.08  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 497 LENSIQHGisrqtPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEdlratlenrtvdyQKHFGIGNVNKRLSSPsfdNG 576
Cdd:COG4585   171 LTNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP-------------GGGLGLRGMRERAEAL---GG 229

                          90
                  ....*....|....*...
gi 1897043662 577 TVRVDSRLNEGTEIVITF 594
Cdd:COG4585   230 TLTIGSAPGGGTRVRATL 247
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
397-594 3.52e-07

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 52.60  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 397 QLLQSQINPHFLyNILGSIKTciSLDRLktaDEMITDLTRFYRLtlrKSGDLIAIRDELEIARL----YLEMEKLCHGDS 472
Cdd:COG0642   133 ELLLEELDEEQR-EYLETILR--SADRL---LRLINDLLDLSRL---EAGKLELEPEPVDLAELleevVELFRPLAEEKG 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 473 LSWEIRAEDGIQNFLI----CRFTLQPFLENSIQHGISRQTpcvhISLDVSYGDDTVIITITDNGAGIAPRQLEDL---- 544
Cdd:COG0642   204 IELELDLPDDLPTVRGdpdrLRQVLLNLLSNAIKYTPEGGT----VTVSVRREGDRVRISVEDTGPGIPPEDLERIfepf 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1897043662 545 -RAtlenRTVDYQKHFGIG-NVNKRLSspSFDNGTVRVDSRLNEGTEIVITF 594
Cdd:COG0642   280 fRT----DPSRRGGGTGLGlAIVKRIV--ELHGGTIEVESEPGKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
420-594 1.22e-06

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 49.91  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 420 SLDRLktaDEMITDLTRFYRLTlrkSGDLIAIRDELEIARL----YLEMEKLCHGDSLSWEIRAEDGIQNFLICRFTLQP 495
Cdd:COG2205    62 SAERL---LRLIEDLLDLSRLE---SGKLSLELEPVDLAELleeaVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQ 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 496 ----FLENSIQHGisrqTPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEDL-----RATLENRtvdyQKHFGIG-NVN 565
Cdd:COG2205   136 vlanLLDNAIKYS----PPGGTITISARREGDGVRISVSDNGPGIPEEELERIferfyRGDNSRG----EGGTGLGlAIV 207

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1897043662 566 KRLsspsFD--NGTVRVDSRLNEGTEIVITF 594
Cdd:COG2205   208 KRI----VEahGGTIWVESEPGGGTTFTVTL 234
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 491-590 8.82e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 44.72  E-value: 8.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 491 FTLQPFLENSIQHGI-SRQTPCvHISLDVSYGDDTVIITITDNGAGIAPRQLEDLRATlenrTVDYQKhfGIG----NVN 565
Cdd:cd16957     4 FALQVLVENAIRHAFpKRKENN-EVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKT----TVTSEK--GTGtaleNLN 76

                          90       100
                  ....*....|....*....|....*
gi 1897043662 566 KRLSSPSFDNGTVRVDSRLNEGTEI 590
Cdd:cd16957    77 RRLIGLFGSEACLHIESEVHGGTEV 101
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 497-594 1.26e-05

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 48.24  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 497 LENSIQHGISRQTPCVHISLDVSygDDTVIITITDNGAGIAPRQLEDL-----RatLENRTvDYQKHfGIG--NVNK--- 566
Cdd:COG4251   403 ISNAIKYSRPGEPPRIEIGAERE--GGEWVFSVRDNGIGIDPEYAEKIfeifqR--LHSRD-EYEGT-GIGlaIVKKive 476

                          90       100
                  ....*....|....*....|....*...
gi 1897043662 567 RLsspsfdNGTVRVDSRLNEGTEIVITF 594
Cdd:COG4251   477 RH------GGRIWVESEPGEGATFYFTL 498
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 497-594 2.87e-05

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 46.77  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 497 LENSIQHGISRQTPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEDLRAtlENRTVDYQKHFGIG--NVNKRLSSpsfD 574
Cdd:COG3290   290 LDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE--RGFSTKLGEGRGLGlaLVKQIVEK---Y 364

                          90       100
                  ....*....|....*....|
gi 1897043662 575 NGTVRVDSRLNEGTEIVITF 594
Cdd:COG3290   365 GGTIEVESEEGEGTVFTVRL 384
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
499-594 3.01e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 43.75  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 499 NSIQHGiSRQTPCVHISLDVSYGDDTVIITITDNGAGIAPRQLEDLRATLENRtvdyqkHFGIGNVnKRLSSpsfdngTV 578
Cdd:COG2172    45 NAVRHA-YGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEG------GRGLFLI-RRLMD------EV 110

                          90
                  ....*....|....*.
gi 1897043662 579 RVDSRlNEGTEIVITF 594
Cdd:COG2172   111 EYESD-PGGTTVRLVK 125
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-594 3.98e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 42.54  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 493 LQPFLENSIQHGisrQTPCVHISLdvSYGDDTVIITITDNGAGIAPrqledlratlenRTVDYQKHFGIGNVNKRLSSPs 572
Cdd:cd16917     5 VQEALTNALKHA---GASRVRVTL--SYTADELTLTVVDDGVGFDG------------PAPPGGGGFGLLGMRERAELL- 66

                          90       100
                  ....*....|....*....|..
gi 1897043662 573 fdNGTVRVDSRLNEGTEIVITF 594
Cdd:cd16917    67 --GGTLTIGSRPGGGTRVTARL 86
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 497-542 3.40e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 40.39  E-value: 3.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1897043662 497 LENSIQHGI--SRQTpcvhISLDVSYGDDTVIITITDNGAGIAPRQLE 542
Cdd:cd16949     5 LENVLRNALrySPSK----ILLDISQDGDQWTITITDDGPGVPEDQLE 48
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
497-594 5.99e-04

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 42.62  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 497 LENSIQHGISRQTpcvhISLDVSYGDDTVIITITDNGAGIAPRQLEDL-----RAtlENRTVDYQKHFGIG-----NVNK 566
Cdd:COG5002   290 LDNAIKYTPEGGT----ITVSLREEDDQVRISVRDTGIGIPEEDLPRIferfyRV--DKSRSRETGGTGLGlaivkHIVE 363

                          90       100
                  ....*....|....*....|....*...
gi 1897043662 567 RLsspsfdNGTVRVDSRLNEGTEIVITF 594
Cdd:COG5002   364 AH------GGRIWVESEPGKGTTFTITL 385
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 397-594 2.32e-03

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 40.55  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 397 QLLQSQINPHFLYNILGSIKTciSLDRlktADEMITDLTRFYRLT--LRKSGDL-IAIRDELEIARLYL-----EMEKLC 468
Cdd:COG4191   169 RRLEDEPDPEELREALERILE--GAER---AAEIVRSLRAFSRRDeeEREPVDLnELIDEALELLRPRLkargiEVELDL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 469 HGDSlsWEIRAeDGIQ------NFLIcrftlqpfleNSIQHGISRQTPCVHISLDVSygDDTVIITITDNGAGIAPRQLE 542
Cdd:COG4191   244 PPDL--PPVLG-DPGQleqvllNLLI----------NAIDAMEEGEGGRITISTRRE--GDYVVISVRDNGPGIPPEVLE 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 543 DLratlenrtvdyqkhF-------------GIGnvnkrLSSpSFD-----NGTVRVDSRLNEGTEIVITF 594
Cdd:COG4191   309 RI--------------FepffttkpvgkgtGLG-----LSI-SYGivekhGGRIEVESEPGGGTTFTITL 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 513-594 4.66e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 39.56  E-value: 4.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 513 HISLDVSYGDDTVIITITDNGAGIAPRQLEDL-------------------RATLENrtvdyqkHfgignvnkrlsspsf 573
Cdd:COG5000   338 EIEVSTRREDGRVRIEVSDNGPGIPEEVLERIfepffttkpkgtglglaivKKIVEE-------H--------------- 395

                          90       100
                  ....*....|....*....|.
gi 1897043662 574 dNGTVRVDSRLNEGTEIVITF 594
Cdd:COG5000   396 -GGTIELESRPGGGTTFTIRL 415
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
522-602 9.95e-03

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 38.68  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897043662 522 DDTVIITITDNGAGIAPrqledlratLENRtvdyQKHFGIGNVNKRLSSPsfdNGTVRVDSRLNEGTEIVITFEQMEDSD 601
Cdd:PRK10935  501 DGEHTVSIRDDGIGIGE---------LKEP----EGHYGLNIMQERAERL---GGTLTISQPPGGGTTVSLTFPSQQEPE 564


                  .
gi 1897043662 602 E 602
Cdd:PRK10935  565 S 565
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH