MULTISPECIES: N-acetylmannosamine kinase [Citrobacter]
Protein Classification
acetate and sugar kinases/Hsc70/actin family protein( domain architecture ID 99298)
acetate and sugar kinases/Hsc70/actin (ASKHA) family protein catalyzes phosphoryl transfer from ATP to their respective substrates
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| ASKHA_ATPase-like super family | cl49607 | ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ... |
1-276 | 1.02e-147 | |||||
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion. The actual alignment was detected with superfamily member PRK05082: Pssm-ID: 483947 [Multi-domain] Cd Length: 291 Bit Score: 415.47 E-value: 1.02e-147
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| Name | Accession | Description | Interval | E-value | |||||
| PRK05082 | PRK05082 | N-acetylmannosamine kinase; Provisional |
1-276 | 1.02e-147 | |||||
N-acetylmannosamine kinase; Provisional Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 415.47 E-value: 1.02e-147
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| ASKHA_NBD_ROK_EcNanK-like | cd24069 | nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
4-276 | 2.64e-106 | |||||
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 310.37 E-value: 2.64e-106
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| ROK | pfam00480 | ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
4-276 | 1.70e-77 | |||||
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif. Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 237.24 E-value: 1.70e-77
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| NagC | COG1940 | Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
1-276 | 4.03e-62 | |||||
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription]; Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 198.58 E-value: 4.03e-62
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| ROK_glcA_fam | TIGR00744 | ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
4-246 | 2.78e-27 | |||||
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General] Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 107.68 E-value: 2.78e-27
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| Name | Accession | Description | Interval | E-value | |||||
| PRK05082 | PRK05082 | N-acetylmannosamine kinase; Provisional |
1-276 | 1.02e-147 | |||||
N-acetylmannosamine kinase; Provisional Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 415.47 E-value: 1.02e-147
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| ASKHA_NBD_ROK_EcNanK-like | cd24069 | nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
4-276 | 2.64e-106 | |||||
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 310.37 E-value: 2.64e-106
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| ROK | pfam00480 | ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
4-276 | 1.70e-77 | |||||
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif. Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 237.24 E-value: 1.70e-77
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| NagC | COG1940 | Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
1-276 | 4.03e-62 | |||||
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription]; Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 198.58 E-value: 4.03e-62
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| ASKHA_NBD_ROK_FnNanK-like | cd24068 | nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
4-276 | 1.04e-44 | |||||
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families. Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 153.10 E-value: 1.04e-44
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| ASKHA_NBD_ROK_TtHK-like | cd24065 | nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
2-272 | 4.18e-37 | |||||
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 133.22 E-value: 4.18e-37
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| ASKHA_NBD_ROK_ApGLK-like | cd24063 | nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
6-276 | 5.37e-35 | |||||
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 128.23 E-value: 5.37e-35
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| ASKHA_NBD_ROK_SgGLK-like | cd24061 | nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
3-272 | 6.58e-31 | |||||
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 117.07 E-value: 6.58e-31
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| ASKHA_NBD_ROK_TM1224-like | cd24059 | nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
3-241 | 8.13e-31 | |||||
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members. Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 116.92 E-value: 8.13e-31
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| ASKHA_ATPase_ROK_BsXylR-like | cd24076 | ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
4-276 | 1.42e-30 | |||||
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes. Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 116.13 E-value: 1.42e-30
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| ASKHA_ATPase_ROK | cd23763 | ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
4-276 | 8.93e-28 | |||||
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains. Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 107.16 E-value: 8.93e-28
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| ROK_glcA_fam | TIGR00744 | ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
4-246 | 2.78e-27 | |||||
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General] Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 107.68 E-value: 2.78e-27
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| ASKHA_NBD_ROK_TmGLK-like | cd24064 | nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
4-256 | 2.37e-26 | |||||
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 104.89 E-value: 2.37e-26
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| ASKHA_NBD_ROK-like | cd24152 | nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
2-276 | 3.16e-25 | |||||
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families. Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 101.49 E-value: 3.16e-25
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| ASKHA_NBD_ROK_BsGLK-like | cd24062 | nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
6-250 | 3.18e-24 | |||||
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 99.29 E-value: 3.18e-24
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| ASKHA_NBD_ROK_NAGK | cd24057 | nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
5-246 | 8.31e-24 | |||||
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 98.07 E-value: 8.31e-24
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| ASKHA_ATPase_ROK_CYANR | cd24073 | ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
10-250 | 5.37e-21 | |||||
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 90.30 E-value: 5.37e-21
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| ASKHA_ATPase_ROK_NagC | cd24075 | ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
3-260 | 1.87e-19 | |||||
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 86.27 E-value: 1.87e-19
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| ASKHA_ATPase_ROK_Mlc | cd24074 | ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
4-268 | 3.24e-16 | |||||
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 77.35 E-value: 3.24e-16
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| ASKHA_NBD_ROK_EcFRK-like | cd24066 | nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
4-243 | 8.02e-16 | |||||
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 75.70 E-value: 8.02e-16
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| ASKHA_NBD_ROK_AlsK | cd24070 | nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
1-249 | 3.73e-14 | |||||
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 71.04 E-value: 3.73e-14
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| ASKHA_NBD_ROK_GNE | cd24060 | nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
4-268 | 1.01e-12 | |||||
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 67.06 E-value: 1.01e-12
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| ASKHA_ATPase_ROK_YphH-like | cd24072 | ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
86-268 | 9.56e-12 | |||||
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 64.36 E-value: 9.56e-12
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| ASKHA_NBD_ROK_PPGK | cd24058 | nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ... |
3-115 | 1.02e-11 | |||||
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families. Pssm-ID: 466908 [Multi-domain] Cd Length: 239 Bit Score: 63.36 E-value: 1.02e-11
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| ASKHA_ATPase_ROK_Lmo0178-like | cd24071 | ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
4-179 | 2.70e-11 | |||||
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 63.07 E-value: 2.70e-11
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| PRK13310 | PRK13310 | N-acetyl-D-glucosamine kinase; Provisional |
7-241 | 2.80e-10 | |||||
N-acetyl-D-glucosamine kinase; Provisional Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 60.00 E-value: 2.80e-10
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| ASKHA_ATPase_ROK_SaXylR-like | cd24077 | ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
3-179 | 6.04e-09 | |||||
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members. Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 55.62 E-value: 6.04e-09
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| PRK09698 | PRK09698 | D-allose kinase; Provisional |
4-243 | 1.19e-08 | |||||
D-allose kinase; Provisional Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 54.99 E-value: 1.19e-08
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| PRK09557 | PRK09557 | fructokinase; Reviewed |
6-259 | 7.50e-07 | |||||
fructokinase; Reviewed Pssm-ID: 236565 [Multi-domain] Cd Length: 301 Bit Score: 49.64 E-value: 7.50e-07
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| ASKHA_NBD_ROK_BsFRK-like | cd24067 | nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ... |
5-259 | 8.22e-07 | |||||
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466917 [Multi-domain] Cd Length: 285 Bit Score: 49.47 E-value: 8.22e-07
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| PRK13311 | PRK13311 | N-acetyl-D-glucosamine kinase; Provisional |
7-175 | 2.57e-04 | |||||
N-acetyl-D-glucosamine kinase; Provisional Pssm-ID: 106271 [Multi-domain] Cd Length: 256 Bit Score: 41.55 E-value: 2.57e-04
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| ASKHA_NBD_eukNAGK-like | cd24007 | nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) ... |
4-250 | 1.16e-03 | |||||
nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) family; The eukaryotic-type NAGK-like family includes a group of proteins similar to eukaryotic N-acetyl-D-glucosamine kinases, such as Vibrio cholerae glucosamine kinase GspK, Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK), Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK). NAGK (EC 2.7.1.59), also called GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. GspK (EC 2.7.1.8), also called GlcN kinase, acts as ATP-dependent kinase, which is specific for glucosamine. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. KdgK (EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase, catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. MurK (EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase, catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. The eukaryotic-type N-acetylglucosamine kinase (NAGK) family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains. Pssm-ID: 466857 [Multi-domain] Cd Length: 295 Bit Score: 39.98 E-value: 1.16e-03
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