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Conserved domains on  [gi|1888286095|ref|WP_182401163|]
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tRNA1(Val) (adenine(37)-N6)-methyltransferase [Enterobacter sp. RHBSTW-01064]

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.81e-90

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 266.63  E-value: 1.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095   9 RRDGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASEN 88
Cdd:COG4123     2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPG-ARITGVEIQPEAAELARRN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  89 AAESPWAPRLSVECADILAWAPE-QTSRYDLIVSNPPYYEP--GVECGTPERERARYTGSLDHKALLTSAAELISEEGFF 165
Cdd:COG4123    81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1888286095 166 CVVLPESTGNNFIEIAREIGWNLRLRTDISDTEGRLPHRVLLALSPKEGECFN--DRMVIRGPDQRYSEDYTALTQAF 241
Cdd:COG4123   161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.81e-90

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 266.63  E-value: 1.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095   9 RRDGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASEN 88
Cdd:COG4123     2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPG-ARITGVEIQPEAAELARRN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  89 AAESPWAPRLSVECADILAWAPE-QTSRYDLIVSNPPYYEP--GVECGTPERERARYTGSLDHKALLTSAAELISEEGFF 165
Cdd:COG4123    81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1888286095 166 CVVLPESTGNNFIEIAREIGWNLRLRTDISDTEGRLPHRVLLALSPKEGECFN--DRMVIRGPDQRYSEDYTALTQAF 241
Cdd:COG4123   161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-125 9.99e-15

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 71.73  E-value: 9.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAESpWAPRLSVECADIlaWAPEQTSRYDLIVSNPPY 125
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKERPD-AEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDW--FEPLPGGRFDLIVSNPPY 185
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 46-125 2.88e-13

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 67.11  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSGLVALMLAQRtEDHVTIDAVELDAQAAGQASENAAespwapRLSVE-----CADILAWAPEQtsRYDLIV 120
Cdd:TIGR03534  88 PRVLDLGTGSGAIALALAKE-RPDARVTAVDISPEALAVARKNAR------RLGLEnveflQGDWFEPLPSG--KFDLIV 158


                  ....*
gi 1888286095 121 SNPPY 125
Cdd:TIGR03534 159 SNPPY 163
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-122 7.86e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 7.86e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1888286095  48 ILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAESPwaPRLSVECADILAWaPEQTSRYDLIVSN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVT--GVDLSPEMLERARERAAEAG--LNVEFVQGDAEDL-PFPDGSFDLVVSS 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-125 1.34e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 1.34e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAEsPWAPRLSVECADILAWAPEQTSRYDLIVSNPPY 125
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVT--GVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-126 2.33e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 40.57  E-value: 2.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095   48 ILDIGTGSGLVALMLAQRTeDHVTidAVELDAQAAGQASEnaaESPWAPRLSVECADILAWAPEQTsRYDLIVSNPPYY 126
Cdd:smart00650  17 VLEIGPGKGALTEELLERA-KRVT--AIEIDPRLAPRLRE---KFAAADNLTVIHGDALKFDLPKL-QPYKVVGNLPYN 88
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.81e-90

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 266.63  E-value: 1.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095   9 RRDGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASEN 88
Cdd:COG4123     2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPG-ARITGVEIQPEAAELARRN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  89 AAESPWAPRLSVECADILAWAPE-QTSRYDLIVSNPPYYEP--GVECGTPERERARYTGSLDHKALLTSAAELISEEGFF 165
Cdd:COG4123    81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1888286095 166 CVVLPESTGNNFIEIAREIGWNLRLRTDISDTEGRLPHRVLLALSPKEGECFN--DRMVIRGPDQRYSEDYTALTQAF 241
Cdd:COG4123   161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 38-208 6.82e-18

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 80.58  E-value: 6.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  38 AWAPVAGVKRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAESPWAPRLSVECADILAWAPEQtSRYD 117
Cdd:COG2890   106 ALLPAGAPPRVLDLGTGSGAIALALAKERPD-ARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGD-GRFD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095 118 LIVSNPPY---------------YEPgvecgtperERARYTGS--LD-HKALLTSAAELISEEGFFCVVLPESTGNNFIE 179
Cdd:COG2890   184 LIVSNPPYipedeiallppevrdHEP---------RLALDGGEdgLDfYRRIIAQAPRLLKPGGWLLLEIGEDQGEAVRA 254

                         170       180       190
                  ....*....|....*....|....*....|
gi 1888286095 180 IAREIGW-NLRLRTDISdteGRlpHRVLLA 208
Cdd:COG2890   255 LLEAAGFaDVETHKDLA---GR--DRVVVA 279
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-125 9.99e-15

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 71.73  E-value: 9.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAESpWAPRLSVECADIlaWAPEQTSRYDLIVSNPPY 125
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKERPD-AEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDW--FEPLPGGRFDLIVSNPPY 185
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 46-125 2.88e-13

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 67.11  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSGLVALMLAQRtEDHVTIDAVELDAQAAGQASENAAespwapRLSVE-----CADILAWAPEQtsRYDLIV 120
Cdd:TIGR03534  88 PRVLDLGTGSGAIALALAKE-RPDARVTAVDISPEALAVARKNAR------RLGLEnveflQGDWFEPLPSG--KFDLIV 158


                  ....*
gi 1888286095 121 SNPPY 125
Cdd:TIGR03534 159 SNPPY 163
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-122 2.56e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 61.38  E-value: 2.56e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDHvTIDAVELDAQAAGQASENaaespwAPRLSVECADILAWAPEQtsRYDLIVSN 122
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERFPGA-RVTGVDLSPEMLARARAR------LPNVRFVVADLRDLDPPE--PFDLVVSN 70
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-122 7.86e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 7.86e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1888286095  48 ILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAESPwaPRLSVECADILAWaPEQTSRYDLIVSN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVT--GVDLSPEMLERARERAAEAG--LNVEFVQGDAEDL-PFPDGSFDLVVSS 70
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 39-125 8.09e-12

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 63.30  E-value: 8.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  39 WAPVAGVKRILDIGTGSGLVALMLAQRTEdHVTIDAVELDAQAAGQASENAAESPWAPRLSVECADILAWAPEQtsRYDL 118
Cdd:TIGR03533 116 WLEPEPVKRILDLCTGSGCIAIACAYAFP-EAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR--KYDL 192


                  ....*..
gi 1888286095 119 IVSNPPY 125
Cdd:TIGR03533 193 IVSNPPY 199
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-125 1.34e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 1.34e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAEsPWAPRLSVECADILAWAPEQTSRYDLIVSNPPY 125
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVT--GVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-121 3.13e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 59.94  E-value: 3.13e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1888286095  47 RILDIGTGSGLVALMLAQRTedHVTIDAVELDAQAAGQASENAAESPWAPRLSVECADILAWAPEQtsRYDLIVS 121
Cdd:COG2230    54 RVLDIGCGWGGLALYLARRY--GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADG--QFDAIVS 124
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 41-125 4.86e-10

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 57.12  E-value: 4.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  41 PVAGVKRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAEsPWAPRLSVECADILAWAPEQtsRYDLIV 120
Cdd:COG2813    46 PEPLGGRVLDLGCGYGVIGLALAKRNPE-ARVTLVDVNARAVELARANAAA-NGLENVEVLWSDGLSGVPDG--SFDLIL 121


                  ....*
gi 1888286095 121 SNPPY 125
Cdd:COG2813   122 SNPPF 126
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-130 7.42e-10

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 56.44  E-value: 7.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTeDHVTIDAVELDAQAAGQASENAAESPwAPRLSVECADILAWAPEQtsRYDLIVSNPPY 125
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKES-PDAELTMVDINARALESARENLAANG-LENGEVVASDVYSGVEDG--KFDLIISNPPF 108


                  ....*
gi 1888286095 126 YEPGV 130
Cdd:pfam05175 109 HAGLA 113
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 46-122 2.16e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 53.87  E-value: 2.16e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDhvtIDAVELDAQAAGQASENAAESpwapRLSVECADILAWAPEQtSRYDLIVSN 122
Cdd:COG2227    26 GRVLDVGCGTGRLALALARRGAD---VTGVDISPEALEIARERAAEL----NVDFVQGDLEDLPLED-GSFDLVICS 94
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 44-127 3.95e-09

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 54.42  E-value: 3.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  44 GVKRILDIGTGSGLVALMLAQRTEDHVTIDAVELDAQAAGQASENAAESPWAPRLSVECADILAWAPE-QTSRYDLIV-- 120
Cdd:COG4122    16 GAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVLPRlADGPFDLVFid 95

                          90
                  ....*....|.
gi 1888286095 121 ----SNPPYYE 127
Cdd:COG4122    96 adksNYPDYLE 106
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 44-152 3.96e-09

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 55.82  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  44 GVKRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAESPWAPRLSVECADIlaWAPEQTSRYDLIVSNP 123
Cdd:TIGR00536 114 PILHILDLGTGSGCIALALAYEFPN-AEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNL--FEPLAGQKIDIIVSNP 190

                          90       100
                  ....*....|....*....|....*....
gi 1888286095 124 PYyepgvecgTPERERARYTGSLDHKALL 152
Cdd:TIGR00536 191 PY--------IDEEDLADLPNVVRFEPLL 211
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-125 3.43e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 51.82  E-value: 3.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDHVtidAVELDAQAAGQASENAAESPWAPR-LSVECADILawAPEQTSRYDLIVSNPP 124
Cdd:PRK14968   25 DRVLEVGTGSGIVAIVAAKNGKKVV---GVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLF--EPFRGDKFDVILFNPP 99


                  .
gi 1888286095 125 Y 125
Cdd:PRK14968  100 Y 100
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
46-122 4.93e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 52.48  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSG---LVALML-AQRtedhvtIDAVELDAQAAGQASENAAESPWAPRLSVECADILAwapeqTSRYDLIVS 121
Cdd:COG2264   150 KTVLDVGCGSGilaIAAAKLgAKR------VLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLLE-----DGPYDLVVA 218


                  .
gi 1888286095 122 N 122
Cdd:COG2264   219 N 219
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
46-121 7.61e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 51.58  E-value: 7.61e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAESPWAPRLSVECADilAWA---PEQTsryDLIVS 121
Cdd:COG4076    37 DVVLDIGTGSGLLSMLAARAGAKKVY--AVEVNPDIAAVARRIIAANGLSDRITVINAD--ATDldlPEKA---DVIIS 108
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-169 1.77e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.91  E-value: 1.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAESPwAPRLSVECADILAWAPEQTSRYDLIVSNppyy 126
Cdd:COG0500    29 RVLDLGCGTGRNLLALAARFGGRVI--GIDLSPEAIALARARAAKAG-LGNVEFLVADLAELDPLPAESFDLVVAF---- 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1888286095 127 epGVECGTPERERarytgsldhKALLTSAAELISEEGFFCVVL 169
Cdd:COG0500   102 --GVLHHLPPEER---------EALLRELARALKPGGVLLLSA 133
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 38-124 2.36e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 50.56  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  38 AWAPVAGVKRILDIGTGSGLVALMLAQRTEdHVTidAVELDAQAAGQASENAAESPWaPRLSVECADILAWAPEQ--TSR 115
Cdd:COG2265   227 EWLDLTGGERVLDLYCGVGTFALPLARRAK-KVI--GVEIVPEAVEDARENARLNGL-KNVEFVAGDLEEVLPELlwGGR 302


                  ....*....
gi 1888286095 116 YDLIVSNPP 124
Cdd:COG2265   303 PDVVVLDPP 311
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-208 6.72e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 48.07  E-value: 6.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  38 AWAPVAGVKRILDIGTGSGLVALMLAQRTEDhvtIDAVELDAQAAGQASENAAESpwaprlSVECADILAWaPEQTSRYD 117
Cdd:COG4976    40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGYR---LTGVDLSEEMLAKAREKGVYD------RLLVADLADL-AEPDGRFD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095 118 LIVSnppyyepgvecgtpereraryTGSLDH----KALLTSAAELISEEGFFCVVLPESTGNNFIEIAREigwnlRLRTD 193
Cdd:COG4976   110 LIVA---------------------ADVLTYlgdlAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD-----YVRDL 163

                         170
                  ....*....|....*
gi 1888286095 194 ISDTEGRLPHRVLLA 208
Cdd:COG4976   164 LAAAGFEVPGLLVVA 178
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 35-122 1.13e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.91  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  35 LLGAWAPVAGvKRILDIGTGSGLVALMLAQRtedHVTIDAVELDAQAAGQASENAAESPWapRLSVECADILAWaPEQTS 114
Cdd:COG2226    14 LLAALGLRPG-ARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDL-PFPDG 86


                  ....*...
gi 1888286095 115 RYDLIVSN 122
Cdd:COG2226    87 SFDLVISS 94
PRK14967 PRK14967
putative methyltransferase; Provisional
 47-168 1.37e-06

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 47.74  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAESpwAPRLSVECADILAWAPEQtsRYDLIVSNPPYY 126
Cdd:PRK14967   39 RVLDLCTGSGALAVAAAAAGAGSVT--AVDISRRAVRSARLNALLA--GVDVDVRRGDWARAVEFR--PFDVVVSNPPYV 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1888286095 127 ePGVECGTPERERAR-YTGSLDHKALL----TSAAELISEEGFFCVV 168
Cdd:PRK14967  113 -PAPPDAPPSRGPARaWDAGPDGRAVLdrlcDAAPALLAPGGSLLLV 158
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
46-122 3.81e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 46.68  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSG---LVALML-AQRtedhvtIDAVELDAQAAGQASENAAESPwaprlsveCADILAwAPEQTSRYDLIVS 121
Cdd:PRK00517  121 KTVLDVGCGSGilaIAAAKLgAKK------VLAVDIDPQAVEAARENAELNG--------VELNVY-LPQGDLKADVIVA 185


                  .
gi 1888286095 122 N 122
Cdd:PRK00517  186 N 186
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 32-127 3.83e-06

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 46.00  E-value: 3.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  32 DGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEDHVTIDaveLDAQAAGQASENAAESpwAPRLSVECADIlawAPE 111
Cdd:TIGR00537   7 DSLLLEANLRELKPDDVLEIGAGTGLVAIRLKGKGKCILTTD---INPFAVKELRENAKLN--NVGLDVVMTDL---FKG 78

                          90
                  ....*....|....*.
gi 1888286095 112 QTSRYDLIVSNPPYYE 127
Cdd:TIGR00537  79 VRGKFDVILFNPPYLP 94
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 43-186 6.54e-06

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 45.42  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  43 AGVK---RILD--IGTGSGLV--ALMLAQR------TEDHVTIDAVELDAQAAGQASENAAESPWAPRLSVECADILAwA 109
Cdd:pfam01170  24 AGWKpgdPLLDpmCGSGTILIeaALMGANIapgkfdARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAAD-L 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1888286095 110 PEQTSRYDLIVSNPPYyepGVECGTPERERARYtgsldhKALLTSAAELISEEGFFCVVLPESTgnNFIEIAREIGW 186
Cdd:pfam01170 103 PLLEGSVDVIVTNPPY---GIRLGSKGALEALY------PEFLREAKRVLRGGGWLVLLTAENK--DFEKAARERAW 168
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 47-136 2.18e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 43.92  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEdHVTidAVELDAQAAGQASENAAESPWaPRLSVECADILAWAPEQtSRYDLIVsnppyy 126
Cdd:COG2518    69 RVLEIGTGSGYQAAVLARLAG-RVY--SVERDPELAERARERLAALGY-DNVTVRVGDGALGWPEH-APFDRII------ 137

                          90
                  ....*....|
gi 1888286095 127 epgVECGTPE 136
Cdd:COG2518   138 ---VTAAAPE 144
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 2-131 3.25e-05

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 43.64  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095   2 SQLKAQLRRdgFTFKqffvaHDRCAMKVGTD-GILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEDHVTIDAVELDAQ 80
Cdd:pfam01596   7 HEYLKELRE--ETAK-----LPLAPMQVSPDeGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDIDPE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1888286095  81 AAGQASENAAESPWAPRLSVECADILAWAPEQT-----SRYDLIV------SNPPYYEPGVE 131
Cdd:pfam01596  80 AYEIAKKFIQKAGVAHKISFILGPALKVLEQLTqdkplPEFDFIFidadksNYPNYYERLLE 141
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
46-124 5.49e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.58  E-value: 5.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDHVTidAVELDAQAAGQASENAAESpwAPRLSVECADILAWAPEqtSRYDLIVSNPP 124
Cdd:COG2263    47 KTVLDLGCGTGMLAIGAALLGAKKVV--GVDIDPEALEIARENAERL--GVRVDFIRADVTRIPLG--GSVDTVVMNPP 119
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
 40-124 5.70e-05

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 43.70  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  40 APVAGVKRILDIGTGSGLVALMLAqRTEDHVTIDAVELDAQAAGQASENAA------ESPWAPRLSVECADILAWAPEQT 113
Cdd:COG4262   282 AAHPRPRRVLVLGGGDGLAAREVL-KYPDVESVTLVDLDPEVTDLAKTNPFlrelngGALNDPRVTVVNADAFQFLRETD 360

                          90
                  ....*....|.
gi 1888286095 114 SRYDLIVSNPP 124
Cdd:COG4262   361 EKYDVIIVDLP 371
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 37-188 1.17e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.47  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  37 GAWAP--------VAGVK---RILD--IGTGSGLV-ALMLAqrtedhVTIDAVELDAQAAGQASENAAespWA--PRLSV 100
Cdd:COG1041     8 GSLDPrlaralvnLAGAKegdTVLDpfCGTGTILIeAGLLG------RRVIGSDIDPKMVEGARENLE---HYgyEDADV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095 101 ECADILAwAPEQTSRYDLIVSNPPYyepgvecgtpererARYTGSLDH------KALLTSAAELISEEGFFCVVLPEStg 174
Cdd:COG1041    79 IRGDARD-LPLADESVDAIVTDPPY--------------GRSSKISGEellelyEKALEEAARVLKPGGRVVIVTPRD-- 141

                         170
                  ....*....|....
gi 1888286095 175 nnFIEIAREIGWNL 188
Cdd:COG1041   142 --IDELLEEAGFKV 153
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 48-125 1.50e-04

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 42.54  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  48 ILDIGTGSGLVALML------AQRTEDHVTIDAVELdaqaagqASENAAESPWAPRLSVECADilaWAPE-QTSRYDLIV 120
Cdd:PRK01544  142 ILELGTGSGCIAISLlcelpnANVIATDISLDAIEV-------AKSNAIKYEVTDRIQIIHSN---WFENiEKQKFDFIV 211


                  ....*
gi 1888286095 121 SNPPY 125
Cdd:PRK01544  212 SNPPY 216
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 47-126 2.11e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 41.65  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGlvAL--MLAQRTeDHVTidAVELDAQAAGQASENAAEspwAPRLSVECADILAWAPEQ--TSRYDLIVSN 122
Cdd:COG0030    40 TVLEIGPGLG--ALtrALLERA-ARVT--AVEIDRRLAAILRETFAA---YPNLTVIEGDALKVDLPAlaAGEPLKVVGN 111


                  ....
gi 1888286095 123 PPYY 126
Cdd:COG0030   112 LPYN 115
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-126 2.33e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 40.57  E-value: 2.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095   48 ILDIGTGSGLVALMLAQRTeDHVTidAVELDAQAAGQASEnaaESPWAPRLSVECADILAWAPEQTsRYDLIVSNPPYY 126
Cdd:smart00650  17 VLEIGPGKGALTEELLERA-KRVT--AIEIDPRLAPRLRE---KFAAADNLTVIHGDALKFDLPKL-QPYKVVGNLPYN 88
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
47-173 4.99e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 40.70  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDHVTIDAVELDAQAAGQASENAAESPWAprLSVECADILawAPEQTSRYDLIVSNPP-- 124
Cdd:COG0827   118 RILDPAVGTGNLLTTVLNQLKKKVNAYGVEVDDLLIRLAAVLANLQGHP--VELFHQDAL--QPLLIDPVDVVISDLPvg 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1888286095 125 YYepgvecgtPERERA-RYTGSLD------HKALLTSAAELISEEGFFCVVLPEST 173
Cdd:COG0827   194 YY--------PNDERAkRFKLKADeghsyaHHLFIEQSLNYLKPGGYLFFLVPSNL 241
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 69-166 6.15e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 40.55  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  69 HVTidAVELDAQAAGQASENAAESPWAPRLSVECADILAW---APEQTSRYDLIVSNPPYYEPgvecgtpeRERARYTGS 145
Cdd:COG1092   241 SVT--SVDLSATALEWAKENAALNGLDDRHEFVQADAFDWlreLAREGERFDLIILDPPAFAK--------SKKDLFDAQ 310

                          90       100
                  ....*....|....*....|...
gi 1888286095 146 LDHKALLTSAAELISEEG--FFC 166
Cdd:COG1092   311 RDYKDLNRLALKLLAPGGilVTS 333
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 47-129 9.09e-04

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 40.06  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAEspWAPRLSVECADILAWAPEQTSRYDLIVSNPPYY 126
Cdd:PRK14966  254 RVWDLGTGSGAVAVTVALERPD-AFVRASDISPPALETARKNAAD--LGARVEFAHGSWFDTDMPSEGKWDIIVSNPPYI 330


                  ...
gi 1888286095 127 EPG 129
Cdd:PRK14966  331 ENG 333
TPMT pfam05724
Thiopurine S-methyltransferase (TPMT); This family consists of thiopurine S-methyltransferase ...
 47-168 1.37e-03

Thiopurine S-methyltransferase (TPMT); This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines.


Pssm-ID: 399030  Cd Length: 218  Bit Score: 38.95  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRtEDHVTidAVELDAQAAGQASENAAESP-----------WAPRLSVECADILAWAPEQTSR 115
Cdd:pfam05724  40 RVLVPLCGKALDMVWLAEQ-GHFVV--GVEISELAVEKFFAEAGLSPpitelsgfkeySSGNISLYCGDFFTLPREELGK 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1888286095 116 YDLIvsnppyYEPGVECGTPERERARYTGSLdhKALLTSAAeliseEGFFCVV 168
Cdd:pfam05724 117 FDLI------YDRAALCALPPEMRPRYAKQM--YELLPPGG-----RGLLITL 156
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-122 1.92e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.58  E-value: 1.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1888286095  49 LDIGTGSGLVALMLAQRTEDhVTIDAVELDAQAAGQASENAAESPW--APRLSVECADILAWAPEQtsrYDLIVSN 122
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPG-LEYTGLDISPAALEAARERLAALGLlnAVRVELFQLDLGELDPGS---FDVVVAS 72
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
46-121 2.74e-03

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 37.89  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888286095  46 KRILDIGTGSGLVALMLAQRTEDhVTIDAVELDAQ---AAGQASENAAESPWAPRLSVECADILAWAPEQTSRYDLIVS 121
Cdd:COG0421    39 KRVLIIGGGDGGLARELLKHPPV-ERVDVVEIDPEvveLAREYFPLLAPAFDDPRLRVVIGDGRAFLREAEESYDVIIV 116
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 46-122 2.97e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 38.02  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDIGTGSG---LVALML-AQRtedhvtIDAVELDAQAAGQASENAAESPWAPRLSVecadILAW-APEQTsrYDLIV 120
Cdd:pfam06325 163 ESVLDVGCGSGilaIAALKLgAKK------VVGVDIDPVAVRAAKENAELNGVEARLEV----YLPGdLPKEK--ADVVV 230


                  ..
gi 1888286095 121 SN 122
Cdd:pfam06325 231 AN 232
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-122 2.97e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.10  E-value: 2.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1888286095  49 LDIGTGSGLVALMLAQRtedHVTIDAVELDAQAAGQASENAAESPwaprLSVECADI--LAWAPEQtsrYDLIVSN 122
Cdd:pfam08241   1 LDVGCGTGLLTELLARL---GARVTGVDISPEMLELAREKAPREG----LTFVVGDAedLPFPDNS---FDLVLSS 66
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
117-189 3.22e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 37.59  E-value: 3.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1888286095 117 DLIVSNPPY-----YEPGVECGTPERERARYTGSLDhkALLTSAAELISEEGFFCVVLPESTGNNFIEIAREIGWNLR 189
Cdd:COG0863    20 DLIVTDPPYnlgkkYGLGRREIGNELSFEEYLEFLR--EWLAECYRVLKPGGSLYVNIGDRYISRLIAALRDAGFKLR 95
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
47-127 3.25e-03

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 38.00  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  47 RILDIGTGSGLVALMLAQRTED-HVTIDAVELDAQAAGQA--SENAAESpwaprlSVECADILAwapEQTSRYDLIVSNP 123
Cdd:PRK09489  199 KVLDVGCGAGVLSAVLARHSPKiRLTLSDVSAAALESSRAtlAANGLEG------EVFASNVFS---DIKGRFDMIISNP 269


                  ....
gi 1888286095 124 PYYE 127
Cdd:PRK09489  270 PFHD 273
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 46-131 3.82e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 36.98  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  46 KRILDI--GTGS-GLVALmlaQRTEDHVTidAVELDAQAAGQASENAAESPWAPRLSVECADILAWAPEQTS-RYDLIVS 121
Cdd:COG0742    43 ARVLDLfaGSGAlGLEAL---SRGAASVV--FVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRFLKRLAGePFDLVFL 117

                          90
                  ....*....|
gi 1888286095 122 NPPYYEPGVE 131
Cdd:COG0742   118 DPPYAKGLLE 127
PRK06202 PRK06202
hypothetical protein; Provisional
 43-122 4.88e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 37.29  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  43 AGVKRILDIGTGSGLVALML---AQRTEDHVTIDAVELDAQAAGQASENAAespwAPRLSVECA--DILAWAPEqtsRYD 117
Cdd:PRK06202   59 DRPLTLLDIGCGGGDLAIDLarwARRDGLRLEVTAIDPDPRAVAFARANPR----RPGVTFRQAvsDELVAEGE---RFD 131


                  ....*
gi 1888286095 118 LIVSN 122
Cdd:PRK06202  132 VVTSN 136
PRK03612 PRK03612
polyamine aminopropyltransferase;
38-124 9.95e-03

polyamine aminopropyltransferase;


Pssm-ID: 235139 [Multi-domain]  Cd Length: 521  Bit Score: 36.74  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888286095  38 AWAPVAGVKRILDIGTGSGLvAL--MLAQRTEDHVTIdaVELDAQAAGQASENAA------ESPWAPRLSVECADILAWA 109
Cdd:PRK03612  291 AMAASARPRRVLVLGGGDGL-ALreVLKYPDVEQVTL--VDLDPAMTELARTSPAlralngGALDDPRVTVVNDDAFNWL 367

                          90
                  ....*....|....*
gi 1888286095 110 PEQTSRYDLIVSNPP 124
Cdd:PRK03612  368 RKLAEKFDVIIVDLP 382
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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