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Conserved domains on  [gi|1887198101|ref|WP_181988613|]
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MULTISPECIES: IclR family transcriptional regulator [Hungatella]

Protein Classification

IclR family transcriptional regulator( domain architecture ID 11444403)

IclR family transcriptional regulator functions as an activator or repressor of genes involved in primary and secondary metabolism, virulence, quorum sensing, and sporulation

CATH:  1.10.10.10|3.30.450.40
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  16472303|16597823

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
10-257 2.21e-84

DNA-binding transcriptional regulator, IclR family [Transcription];


:

Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 252.05  E-value: 2.21e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  10 EKYMLQSVTNALRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGRC-RLGMKFSYFGSVVLARM 87
Cdd:COG1414     1 DRSGVQSLERALAILEALAEAGgGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRyRLGPRLLELGSAALRRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  88 EILQASRPHLEELQRNVRETVHLAIWDDDwNIRFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDN 167
Cdd:COG1414    81 DLRRLARPVLEELAEETGETVHLAVLDGD-EVVYVARVEGPRPVRVSSRVGSRLPLHATASGKALLAFLPEEELEALLAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 168 VPLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMT-EHLSEYPTKVM 246
Cdd:COG1414   160 AGLPRFTPNTITDPAALRAELAEIRERGYAVDDGELEPGVRAVAAPVFDADGRVVAALSVSGPSSRLTeERLEELAPALR 239

                         250
                  ....*....|.
gi 1887198101 247 DTARLISENLS 257
Cdd:COG1414   240 AAAREISRALG 250
 
Name Accession Description Interval E-value
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
10-257 2.21e-84

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 252.05  E-value: 2.21e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  10 EKYMLQSVTNALRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGRC-RLGMKFSYFGSVVLARM 87
Cdd:COG1414     1 DRSGVQSLERALAILEALAEAGgGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRyRLGPRLLELGSAALRRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  88 EILQASRPHLEELQRNVRETVHLAIWDDDwNIRFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDN 167
Cdd:COG1414    81 DLRRLARPVLEELAEETGETVHLAVLDGD-EVVYVARVEGPRPVRVSSRVGSRLPLHATASGKALLAFLPEEELEALLAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 168 VPLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMT-EHLSEYPTKVM 246
Cdd:COG1414   160 AGLPRFTPNTITDPAALRAELAEIRERGYAVDDGELEPGVRAVAAPVFDADGRVVAALSVSGPSSRLTeERLEELAPALR 239

                         250
                  ....*....|.
gi 1887198101 247 DTARLISENLS 257
Cdd:COG1414   240 AAAREISRALG 250
PRK15090 PRK15090
DNA-binding transcriptional regulator KdgR; Provisional
 16-256 1.11e-48

DNA-binding transcriptional regulator KdgR; Provisional


Pssm-ID: 185046 [Multi-domain]  Cd Length: 257  Bit Score: 161.34  E-value: 1.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  16 SVTNALR---IIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKK----DKYgrcRLGMKFSYFGSVVLARME 88
Cdd:PRK15090    9 SVSSVLKvfgILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQegesEKY---SLTLKLFELGAKALQNVD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  89 ILQASRPHLEELQRNVRETVHLAIWDDDwNIRFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDNV 168
Cdd:PRK15090   86 LIRSADIQMREISRLTKETIHLGALDED-SIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVREILSGV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 169 PLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMTE-HLSEYPTKVMD 247
Cdd:PRK15090  165 EFKRSTEKTITSTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEeRKQEYVAMLHT 244


                  ....*....
gi 1887198101 248 TARLISENL 256
Cdd:PRK15090  245 AARKISEQM 253
pcaR_pcaU TIGR02431
beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this ...
 13-237 1.83e-41

beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions]


Pssm-ID: 131484 [Multi-domain]  Cd Length: 248  Bit Score: 142.40  E-value: 1.83e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  13 MLQSVTNALRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKyGRCRLGMKFSYFGSVVLARMEILQ 91
Cdd:TIGR02431   4 FVASLARGLAVIEAFGAERpRLTLTDVAEATGLTRAAARRFLLTLVELGYVTSDG-RLFWLTPRVLRLGYAYLSSAPLPK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  92 ASRPHLEELQRNVRETVHLAIWDDDWnIRFIDKIDGAIAFHMQSFVG--LPktCYSTATGKSMLAFMGDDFIRDFLDNVP 169
Cdd:TIGR02431  83 VAQPLLERLSAQTHESCSVAVLDGDE-IVYVARSPTHRIMSVGLSVGtrLP--AYCTSMGRVLLAGLDDEELDEYLARST 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1887198101 170 LTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMTEH 237
Cdd:TIGR02431 160 LQALTPRTITDRDALLAELLAVRAQGYALVDQELELGLRSIAVPIRNARGQVVAALNVSTHAARTTPE 227
IclR pfam01614
Bacterial transcriptional regulator; This family of bacterial transcriptional regulators ...
 135-253 4.28e-37

Bacterial transcriptional regulator; This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426346 [Multi-domain]  Cd Length: 128  Bit Score: 127.40  E-value: 4.28e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 135 SFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDNVPLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPV 214
Cdd:pfam01614   7 SAIGRRLPLHATAIGKALLAWLDEEELEAYLERYELKRLTPNTITDPEALLEELAQIREQGYAVDREEHELGVRCIAAPI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1887198101 215 IDTSQKPIAAISISGPTVRMTE-HLSEYPTKVMDTARLIS 253
Cdd:pfam01614  87 FDASGDVVAAISVSGPTSRLTEeELDYLLALLREAARKIS 126
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
15-102 1.46e-22

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 88.41  E-value: 1.46e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101   15 QSVTNALRIIELLGEY-NFLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDK-YGRCRLGMKFSYFGSVVLARMEILQA 92
Cdd:smart00346   2 QSLERGLAVLRALAEEpGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGqNGRYRLGPKVLELGQSYLSSLDLREV 81

                           90
                   ....*....|
gi 1887198101   93 SRPHLEELQR 102
Cdd:smart00346  82 AKPVLEELSR 91
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 21-69 6.22e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 6.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1887198101  21 LRIIELLGEyNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGR 69
Cdd:cd00090    10 LRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
 
Name Accession Description Interval E-value
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
10-257 2.21e-84

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 252.05  E-value: 2.21e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  10 EKYMLQSVTNALRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGRC-RLGMKFSYFGSVVLARM 87
Cdd:COG1414     1 DRSGVQSLERALAILEALAEAGgGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRyRLGPRLLELGSAALRRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  88 EILQASRPHLEELQRNVRETVHLAIWDDDwNIRFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDN 167
Cdd:COG1414    81 DLRRLARPVLEELAEETGETVHLAVLDGD-EVVYVARVEGPRPVRVSSRVGSRLPLHATASGKALLAFLPEEELEALLAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 168 VPLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMT-EHLSEYPTKVM 246
Cdd:COG1414   160 AGLPRFTPNTITDPAALRAELAEIRERGYAVDDGELEPGVRAVAAPVFDADGRVVAALSVSGPSSRLTeERLEELAPALR 239

                         250
                  ....*....|.
gi 1887198101 247 DTARLISENLS 257
Cdd:COG1414   240 AAAREISRALG 250
PRK15090 PRK15090
DNA-binding transcriptional regulator KdgR; Provisional
 16-256 1.11e-48

DNA-binding transcriptional regulator KdgR; Provisional


Pssm-ID: 185046 [Multi-domain]  Cd Length: 257  Bit Score: 161.34  E-value: 1.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  16 SVTNALR---IIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKK----DKYgrcRLGMKFSYFGSVVLARME 88
Cdd:PRK15090    9 SVSSVLKvfgILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQegesEKY---SLTLKLFELGAKALQNVD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  89 ILQASRPHLEELQRNVRETVHLAIWDDDwNIRFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDNV 168
Cdd:PRK15090   86 LIRSADIQMREISRLTKETIHLGALDED-SIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVREILSGV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 169 PLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMTE-HLSEYPTKVMD 247
Cdd:PRK15090  165 EFKRSTEKTITSTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEeRKQEYVAMLHT 244


                  ....*....
gi 1887198101 248 TARLISENL 256
Cdd:PRK15090  245 AARKISEQM 253
pcaR_pcaU TIGR02431
beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this ...
 13-237 1.83e-41

beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions]


Pssm-ID: 131484 [Multi-domain]  Cd Length: 248  Bit Score: 142.40  E-value: 1.83e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  13 MLQSVTNALRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKyGRCRLGMKFSYFGSVVLARMEILQ 91
Cdd:TIGR02431   4 FVASLARGLAVIEAFGAERpRLTLTDVAEATGLTRAAARRFLLTLVELGYVTSDG-RLFWLTPRVLRLGYAYLSSAPLPK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  92 ASRPHLEELQRNVRETVHLAIWDDDWnIRFIDKIDGAIAFHMQSFVG--LPktCYSTATGKSMLAFMGDDFIRDFLDNVP 169
Cdd:TIGR02431  83 VAQPLLERLSAQTHESCSVAVLDGDE-IVYVARSPTHRIMSVGLSVGtrLP--AYCTSMGRVLLAGLDDEELDEYLARST 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1887198101 170 LTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMTEH 237
Cdd:TIGR02431 160 LQALTPRTITDRDALLAELLAVRAQGYALVDQELELGLRSIAVPIRNARGQVVAALNVSTHAARTTPE 227
IclR pfam01614
Bacterial transcriptional regulator; This family of bacterial transcriptional regulators ...
 135-253 4.28e-37

Bacterial transcriptional regulator; This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426346 [Multi-domain]  Cd Length: 128  Bit Score: 127.40  E-value: 4.28e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 135 SFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDNVPLTPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPV 214
Cdd:pfam01614   7 SAIGRRLPLHATAIGKALLAWLDEEELEAYLERYELKRLTPNTITDPEALLEELAQIREQGYAVDREEHELGVRCIAAPI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1887198101 215 IDTSQKPIAAISISGPTVRMTE-HLSEYPTKVMDTARLIS 253
Cdd:pfam01614  87 FDASGDVVAAISVSGPTSRLTEeELDYLLALLREAARKIS 126
PRK11569 PRK11569
glyoxylate bypass operon transcriptional repressor IclR;
14-253 6.10e-36

glyoxylate bypass operon transcriptional repressor IclR;


Pssm-ID: 183206 [Multi-domain]  Cd Length: 274  Bit Score: 128.77  E-value: 6.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  14 LQSVTNALRIIELLGEYNF-LTLTEIAEKLELGKSSVFRLVATLESRGFVKK-DKYGRCRLGMKFSYFGSVVLARMEILQ 91
Cdd:PRK11569   24 VQSLTRGLKLLEWIAESNGsVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQvGELGHWAIGAHAFIVGSSFLQSRNLLA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  92 ASRPHLEELQRNVRETVHLAIWD-DDWNIRFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDNVPL 170
Cdd:PRK11569  104 IVHPILRNLMEDSGETVNLAVLDqSDHQAIIIDQVQCTALMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHRKGL 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 171 TPMTPHTITEPSKLLESLDEIRRSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMTE-HLSEYPTKVMDTA 249
Cdd:PRK11569  184 HAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIFDEHREPFAAISISGPISRITDdRVTELGAMVIKAA 263


                  ....
gi 1887198101 250 RLIS 253
Cdd:PRK11569  264 KEVT 267
PRK10163 PRK10163
HTH-type transcriptional repressor AllR;
34-256 2.13e-24

HTH-type transcriptional repressor AllR;


Pssm-ID: 182279 [Multi-domain]  Cd Length: 271  Bit Score: 98.16  E-value: 2.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  34 TLTEIAEKLELGKSSVFRLVATLESRGFVKKD-KYGRCRLGMKFSYFGSVVLARMEILQASRPHLEELQRNVRETVHLAI 112
Cdd:PRK10163   42 SVSDISLNLDLPLSTTFRLLKVLQAADFVYQDsQLGWWHIGLGVFNVGAAYIHNRDVLSVAGPFMRRLMLLSGETVNVAI 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 113 WDDDWNIrFIDKIDGAIAFHMQSFVGLPKTCYSTATGKSMLAFMGDDFIRDFLDNVPLTPMTPHTITEPSKLLESLDEIR 192
Cdd:PRK10163  122 RNGNEAV-LIGQLECKSMVRMCAPLGSRLPLHASGAGKALLYPLAEEELMSIILQTGLQQFTPTTLVDMPTLLKDLEQAR 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1887198101 193 RSGYCLSVEEDELGLTCIGAPVIDTSQKPIAAISISGPTVRMTE-HLSEYPTKVMDTARLISENL 256
Cdd:PRK10163  201 ELGYTVDKEEHVVGLNCIASAIYDDVGSVVAAISISGPSSRLTEdRFVSQGELVRDTARDISTAL 265
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
15-102 1.46e-22

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 88.41  E-value: 1.46e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101   15 QSVTNALRIIELLGEY-NFLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDK-YGRCRLGMKFSYFGSVVLARMEILQA 92
Cdd:smart00346   2 QSLERGLAVLRALAEEpGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGqNGRYRLGPKVLELGQSYLSSLDLREV 81

                           90
                   ....*....|
gi 1887198101   93 SRPHLEELQR 102
Cdd:smart00346  82 AKPVLEELSR 91
HTH_IclR pfam09339
IclR helix-turn-helix domain;
16-65 5.19e-13

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 62.04  E-value: 5.19e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1887198101  16 SVTNALRIIELLGEYNF-LTLTEIAEKLELGKSSVFRLVATLESRGFVKKD 65
Cdd:pfam09339   1 SLDRALAILDALAEAPGpLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQD 51
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 18-69 8.43e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 45.67  E-value: 8.43e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1887198101  18 TNALRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGR 69
Cdd:COG2512    15 EDERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGR 67
PRK09834 PRK09834
DNA-binding transcriptional regulator;
34-196 1.67e-06

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 48.06  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101  34 TLTEIAEKLELGKSSVFRLVATLESRGFVKK-DKYGRCRLGMKFSYFGSVVLARMEILQASRPHLEELQRNVRETVHLAI 112
Cdd:PRK09834   28 TVGLLAELTGLHRTTVRRLLETLQEEGYVRRsASDDSFRLTLKVRQLSEGFRDEQWISALAAPLLGDLLRRVVWPTDLTT 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887198101 113 WDDD-WNIRFIDKIDGAIAFHmQSFVGLPKTCYSTATGKSMLAFMGD---DFIRDFLDNVPLTPMTPHtiTEPSKLLESL 188
Cdd:PRK09834  108 LDVDaMVIRETTHRFSPLSFH-RAMVGRRLPLLLTAAGRAYLAFCPEeerEALLELLASRPGDEDQLA--RDPARLEAML 184


                  ....*...
gi 1887198101 189 DEIRRSGY 196
Cdd:PRK09834  185 ARTRKRGY 192
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
21-66 1.63e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.58  E-value: 1.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1887198101   21 LRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDK 66
Cdd:smart00347  13 FLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP 58
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 21-64 3.50e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.65  E-value: 3.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1887198101  21 LRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKK 64
Cdd:pfam12802   8 FRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 21-64 5.38e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.22  E-value: 5.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1887198101  21 LRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKK 64
Cdd:pfam01047   6 FHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIER 49
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
21-72 7.19e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 41.73  E-value: 7.19e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1887198101  21 LRIIELLGEYN-FLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGRCRL 72
Cdd:COG1321    12 LKAIYELSEEGgPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITL 64
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
21-64 1.11e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 41.11  E-value: 1.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1887198101  21 LRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKK 64
Cdd:COG1846    41 FRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVER 84
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 21-64 2.21e-04

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 39.42  E-value: 2.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1887198101   21 LRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKK 64
Cdd:smart00344   6 RKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKG 49
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
33-78 2.60e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 39.95  E-value: 2.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1887198101  33 LTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGRCRLGMKFSY 78
Cdd:COG3355    43 LTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEGGGYPYVY 88
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
19-63 1.36e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 39.43  E-value: 1.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1887198101  19 NALRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFVK 63
Cdd:PRK04172    7 NEKKVLKALKELKEATLEELAEKLGLPPEAVMRAAEWLEEKGLVK 51
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
21-69 3.08e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 36.09  E-value: 3.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1887198101  21 LRIIELLGEYNfLTLTEIAEKLELGKSSVFRLVATLESRGFVK-KDKYGR 69
Cdd:COG4189    22 LRILRLLAEEP-LNVNELAEALGLPKSTVSYHIRKLEEAGLIRtEYKPGK 70
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-69 3.56e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 3.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1887198101   22 RIIELL--GEYNFltlTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGR 69
Cdd:smart00418   1 KILKLLaeGELCV---CELAEILGLSQSTVSHHLKKLREAGLVESRREGK 47
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 21-69 6.22e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 6.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1887198101  21 LRIIELLGEyNFLTLTEIAEKLELGKSSVFRLVATLESRGFVKKDKYGR 69
Cdd:cd00090    10 LRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
21-62 6.34e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.95  E-value: 6.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1887198101  21 LRIIELLGEYNFLTLTEIAEKLELGKSSVFRLVATLESRGFV 62
Cdd:pfam13412   4 RKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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