|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
52-461 |
5.36e-69 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 225.58 E-value: 5.36e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 52 VIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQgLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATA 131
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQ-TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 132 ACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDvsfvtlp 211
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGG------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 212 vigeiktWQLTFMIVGLPGVLLALLMILTVREPERKGLKMDANGVAVKASFKNSIGFIKTHrKTFFCHFIGFSFYTMMLY 291
Cdd:cd17328 153 -------WRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKN-PSFILSTLGFTAVSFVTG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 292 SLLGWAPAYYMRHFG---LDASQTGYILGSIILVANTSGALFCGWLIDFFSKRG-YSDAAIRA-GAIGCAALIIPSVLFT 366
Cdd:cd17328 225 ALAFWAPTFFLRAFGvgdLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTpRADPLVCAvGLLAAAPFLFLALVLA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 367 QvDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNLIALGVGTTAVALITD--RYYENTLMVG- 443
Cdd:cd17328 305 L-SNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDllRQNKDSPLAEa 383
|
410 420
....*....|....*....|..
gi 1872276290 444 ----NSISIVNAVAGVIGVFLL 461
Cdd:cd17328 384 aslqYALLLCSFVLVLGGFFFL 405
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-463 |
1.53e-53 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 183.92 E-value: 1.53e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 44 RSSYQWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGI 123
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLAS-AFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 124 AFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLk 203
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 204 dvsfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVreperkglkmdangvavkasfknsigfikthrktffchFIGF 283
Cdd:COG2271 162 --------------GWRAAFLILGLPGLLLALLRFWLL--------------------------------------ALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 284 SFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRGysdaaIRAGAIGCAALIIPSV 363
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL-SLPFLAGIVGSLLGGWLSDRLGRRR-----KLVLAIGLLLAALALL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 364 LFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNLIAlGVGTTAVALITDRY-YENTLMV 442
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG-ALGPLLVGYLLDATgYQAAFLL 342
|
410 420
....*....|....*....|.
gi 1872276290 443 gnsISIVNAVAGVIGVFLLYK 463
Cdd:COG2271 343 ---LAALALLAALLALLLLRE 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
42-420 |
2.89e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 145.12 E-value: 2.89e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 42 PERSSYQWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISV 121
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVT-AYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 122 GIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGL 201
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 202 LkdvsfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVREPERkglkmdangvAVKASFKNSIGFIKTHRKTFFCHFI 281
Cdd:COG2814 161 F---------------GWRWVFLVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 282 GFsFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILGsIILVANTSGALFCGWLIDFFSKRgysdaaiRAGAIGCAALIIP 361
Cdd:COG2814 216 AF-LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA-LFGLGGVLGALLAGRLADRFGRR-------RLLLIGLLLLALG 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1872276290 362 SVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNLIA 420
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-461 |
5.25e-37 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 139.24 E-value: 5.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 49 WYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIAS-AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 129 ATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfv 208
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 209 tlpvigeikTWQLTFMIVGLPGVLLALLMILTVReperkglkmdangvavkasfknsigfikthrkTFFCHFIGFSFYTM 288
Cdd:cd17319 155 ---------GWRWAFIIEGLLGLLLAVLWWFYLR--------------------------------QVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 289 MLYSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdAAIRAGAIGCAALIIPSVLFTQV 368
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLA-AIPFLAGAIGMILGGRLSDRLLRG----ARRLVIIIGLLLAAVGLLLAYLT 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 369 DNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNLIALGVGTTAVALITDRYYENTLMVgnsISI 448
Cdd:cd17319 269 TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFL---FLA 345
|
410
....*....|...
gi 1872276290 449 VNAVAGVIGVFLL 461
Cdd:cd17319 346 AVALLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
46-463 |
1.37e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 124.99 E-value: 1.37e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 46 SYQWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLAFsLFYAFMGVPIAALADKKSRVKIISVGIAF 125
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPV-LVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 126 WSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdv 205
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 206 sfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVREPERKglkmdaNGVAVKASFKNSIGFIKThrKTFFCHFIGFSF 285
Cdd:COG2223 157 ------------GWRNAFLILGILLLVVAVLAWLFLRDPPAG------AAAAAKASLRDQLEALRD--PRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 286 YTMMLYSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdaaiRAGAIGCAALIIPSVLF 365
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLA-ALFALLGALGRPLGGWLSDRIGGR-------RVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 366 TQV-DNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAkFLLISNLIALGVGTTAVALITDRY--YENTLMV 442
Cdd:COG2223 289 ALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYG-LVGAAGGLGGFLGPLLFGALLDATgsYTAAFLV 367
|
410 420
....*....|....*....|.
gi 1872276290 443 gnsiSIVNAVAGVIGVFLLYK 463
Cdd:COG2223 368 ----FAVLALVALVLTLLLYR 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
56-418 |
4.46e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.44 E-value: 4.46e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 56 MVAYILSFVDRQILSLMIEP-IKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACG 134
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLT-LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 135 LSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfvtlpvig 214
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 215 eikTWQLTFMIVGLPGVLLALLMILTVREPERKGLKmdaNGVAVKASFKNSIGFIKTHRKTFFchFIGFSFYTMMLYSLL 294
Cdd:pfam07690 149 ---GWRAAFLILAILSLLAAVLLLLPRPPPESKRPK---PAEEARLSLIVAWKALLRDPVLWL--LLALLLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 295 GWAPAyYMRHFGLDASQTGYILGSIILVAnTSGALFCGWLIDFFSKRgysdAAIRAGAIGCAALIIPSVLFTQVDNMQLS 374
Cdd:pfam07690 221 TYLPL-YQEVLGLSALLAGLLLGLGGLLG-AIGRLLLGRLSDRLGRR----RRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1872276290 375 FALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNL 418
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
57-462 |
6.75e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.97 E-value: 6.75e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 57 VAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLS 136
Cdd:cd06174 3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFAL-FSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 137 KNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKdvsfvtlpvigei 216
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG------------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 217 KTWQLTFMIVGLPGVLLALLMILTVREPERKGLKmdANGVAVKASFKNSIGFIKtHRKTFFCHFIGFSFYTMMLYSLLGW 296
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLVVPDPPESARA--KNEEASSKSVLKLLKRVL-KNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 297 APAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRGYsdaairAGAIGCAALIIPSVLFTQVDNMQLSFA 376
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLL-SLFGLAGALGSLLLGLLSDRLIGRKP------LLLIGLLLMALGLALLLLAPSLLLLLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 377 LIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAkFLLISNLIALGVGTTAVALITDRYYENTLMVgnsisIVNAVAGVI 456
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG-LLNTFGFLGGAIGPLLAGFLLAATFGLTGAF-----LVLAVLLLL 372
|
....*.
gi 1872276290 457 GVFLLY 462
Cdd:cd06174 373 AAILLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
45-406 |
2.17e-22 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 98.97 E-value: 2.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 45 SSYQWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLqgLAFSLF-YAFMGVPIAALADKKSRVKIISVGI 123
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFL--FSAGLIgMAFGALFFGPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 124 AFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIgllk 203
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI---- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 204 dvsfvtlPVIGeiktWQLTFMIVGLPGVLLALLMILTVREPER--------------------------KGLKMDANGVA 257
Cdd:TIGR00895 166 -------PVFG----WRSLFYVGGIAPLLLLLLLMRFLPESIDflvskrpetvrrivnaiapqmqaeaqSALPEQKSTQG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 258 VKASFKNSIGFIKTHRKTFFChFIGFSFYTMMLYSLLGWAPaYYMRHFGLDASQTGyILGSIILVANTSGALFCGWLIDF 337
Cdd:TIGR00895 235 TKRSVFKALFQGKTARITVLL-WLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAA-TGGALFNFGGVIGSIIFGWLADR 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1872276290 338 FSKRGYSDAAIRAGAIgcaaLIIPSVLFTQVDNMQLsfaLIFVAMFFSTFPIPASAAATQMLTPNQLRS 406
Cdd:TIGR00895 312 LGPRVTALLLLLGAVF----AVLVGSTLFSPTLLLL---LGAIAGFFVNGGQSGLYALMALFYPTAIRA 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
94-461 |
3.59e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.95 E-value: 3.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 94 AFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKL 173
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEER 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 174 GRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVREPERKglkmDA 253
Cdd:cd17325 119 GRAMGIFSSAIGLGFLIGPLLGGLLADAL---------------GYRAPFLVCAALALLALVLALLLLPEPRPP----PN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 254 NGVAVKASFKNSIGFIKTHRKTFFCHFIGFSFYT--MMLYSLLgwaPAYYMRHFGLDASQTGYILGsIILVANTSGALFC 331
Cdd:cd17325 180 KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFafGALEPFL---PLYAAELGGLSPAQIGLLFG-AQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 332 GWLIDFFSKRGYsdaaIRAGAIGCAALIIpsvLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAK 411
Cdd:cd17325 256 GKLSDRIGRKPL----ILIGLLLSAVALL---LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1872276290 412 FLLISNlIALGVGTTAVALITDRYYENTLMVgnSISIVNAVAGVIGVFLL 461
Cdd:cd17325 329 FNTAFS-LGMVLGPLLGGFLYDAFGFATPFL--AAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
43-386 |
3.62e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.92 E-value: 3.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 43 ERSSYQWYVVIICMVAYILSFVDrQILSLMIEPIKADLMLSDTQFSLLQgLAFSLFYAFMGVPIAALADKKSRVKIISVG 122
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFAT-ALWGPLIPALKDAFGLSDAQAGLLL-FAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 123 IAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHK---LGRALGVYAIGAFIGSglafLIGGYVI 199
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAasrLNLLHAFFSLGALLGP----LLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 200 GLlkdvsfvtlpviGEIKTWQLTFMIVGLPGVLLALLMILTvreperkGLKMDANGVAVKASFKNSIGFIKTHRKTFFCh 279
Cdd:COG0738 156 LL------------GLSLSWHLPYLILAVLLLLLALLFLRS-------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLG- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 280 FIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdAAIRAGAIGCAALI 359
Cdd:COG0738 216 GLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGL-SLFWGGMTIGRFLGGFLLKRFGPV----RLLRLSALLAAVGL 290
|
330 340
....*....|....*....|....*....
gi 1872276290 360 IPSVLFTQVDNMQLSFALI--FVAMFFST 386
Cdd:COG0738 291 LLALLAPGPWLALIGLALVglGLSLMFPT 319
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
53-461 |
7.34e-21 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 94.29 E-value: 7.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 53 IICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAA 132
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLL-GTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 133 CGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfvtLPV 212
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLL-------PPE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 213 IGeiktWQLTFMIVGLPgVLLALLMILTVREPERKGLKMdANGVAVKASFKNSIGFIKTHRKTFFCHFIGFSFYTMMLYS 292
Cdd:cd17371 154 IA----WRVLFLLGALP-ALLVLFIRRFVKEPPQWQAAR-AARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 293 LLGWAPAYYMRHFGLDASQTGYILGSIILVAnTSGALFCGWLIDFFSKRgysdAAIRAGAIGCAAlIIPSVLFTQVDNMQ 372
Cdd:cd17371 228 ITTWLPSYLTGERGLSFEGSAGYLVVTILGG-FLGYLAGGFLADRIGRR----NNFALFALGSAI-SILLYFFLPLSPTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 373 LSFALIFVAMFFStfpIPASAAATQM--LTPNQLRSqvSAKFLLISnlIALGVGTTAVALITdrYYENTLMVGNSISIVN 450
Cdd:cd17371 302 ILILGFPLGFFAS---GPFSGMGAYLteLFPTAVRA--TAQGFCYN--VGRIIGALFPFLVG--FLATSGSLGTAIAVFA 372
|
410
....*....|.
gi 1872276290 451 AVAGVIGVFLL 461
Cdd:cd17371 373 AVYYIAGLVLA 383
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
72-460 |
4.82e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 91.46 E-value: 4.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 72 MIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGA 151
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLL-VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 152 GEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYvigllkdvsfvtlpvIGEIKTWQLTFMIVGLPGV 231
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL---------------LGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 232 LLALLMILTVREperkglkmDANGVAVKASFKNSIGFIKTHRKTFFCHFIGFSFYTMM--LYSLLGWapaYYMRHFGLDA 309
Cdd:cd17324 165 LAALLLWRLLPS--------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFfaLYTYLAP---FLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 310 SQTGYILGsIILVANTSGALFCGWLIDFFSKrgysdaaiRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFFSTFPI 389
Cdd:cd17324 234 SAIIGLLL-LFGVAGVVGSPLAGRLADRGGR--------RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1872276290 390 PASAAATQMLTPNQLRSQVSAKFLLISNlIALGVGTTAVALITDRYyentlmVGNSISIVNAVAGVIGVFL 460
Cdd:cd17324 305 HSALQTRVLRLAPEARGLASSLYLAAYN-LGGALGAALGGLVLDHG------GWAGVGWVGAALLLLALLL 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-463 |
5.19e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.48 E-value: 5.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 51 VVIICMVAYILSFVDrQILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLAT 130
Cdd:cd17474 1 LYAVFFATLLAVLGV-SIVDPILPAIAEALGASPAQVGLLIT-AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 131 AACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGgyviGLLKDVSfvtl 210
Cdd:cd17474 79 LLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG----GLLAAIS---- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 211 pvigeiktWQLTFMIVGLPGVLLALLMILTVREPERKglkmdanGVAVKASFKNSIGFIKTHRkTFFCHFIGFSFYTMML 290
Cdd:cd17474 151 --------WRYPFFLLAALIPVAFLAILFLLPEPKEK-------AKSSSATKLRDLKKALRGR-GLLTFLVSAFLYFFLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 291 YSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFskrgysDAAIRAGAIGCAALIIPSVLFTQVDN 370
Cdd:cd17474 215 FAFLTYLPFLLELLYGISPIIIGLLF-AGWSVLLALGSLFVGRLLKKR------FGARRILVIGLLLYALSLLLLGFVPS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 371 MQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAkflliSNLIALGVGTTAVALITDRYYENTLMvgNSISIVN 450
Cdd:cd17474 288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS-----LYNFVRFLGQAVGPLLFGLLLEIFGL--SAPFLVG 360
|
410
....*....|...
gi 1872276290 451 AVAGVIGVFLLYK 463
Cdd:cd17474 361 AAIALAAAVLLAL 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
52-459 |
8.16e-20 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 90.74 E-value: 8.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 52 VIICMVAYILSFVDRQILSLMIEPIKADLMLSDTqfSLLQGLAFSLFYAFM---GVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLS--LLQTGLLFAAGFLGRpigALLFGYLGDRIGRKKALILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 129 ATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIgllkdvsfv 208
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLI--------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 209 tlPVIGEIKTWQLTFMIVGLPGVLLALLmiltvreperkglkmdangvavkasfknsigfikthRKTFFCHFIGFSFYTM 288
Cdd:cd17316 150 --PLLSGDWGWRILFLIGALPALLALLL------------------------------------RRRTLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 289 MLYSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdAAIRAGAIGCAALIIPSVLFTQV 368
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYL-LLISLGALVGALIAGLLSDRIGRK----KTLVIGLILSGILALPLFYLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 369 DNMQLsFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNLIALGVGTTAVALITDRYYENTLMVgnsISI 448
Cdd:cd17316 267 SPTLL-LLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL---ILA 342
|
410
....*....|.
gi 1872276290 449 VNAVAGVIGVF 459
Cdd:cd17316 343 LLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
40-330 |
8.34e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.79 E-value: 8.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 40 ATPERSSYQWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKII 119
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVS-AYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 120 SVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVI 199
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 200 GLLkdvsfvtlpvigeikTWQLTFMIVGLPGVllaLLMILTVREPERKGLKMDANGVAVKASFKNSIGFIKTHRKTFFCH 279
Cdd:COG0477 163 AAL---------------GWRWIFLINAPLGL---LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLL 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1872276290 280 FIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILGSIILVANTSGALF 330
Cdd:COG0477 225 LLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALL 275
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
69-456 |
1.07e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.92 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 69 LSLMIEPIKADLMLSDTQFSLLQGLAFsLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLS 148
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPL-LAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 149 VGAGEAALSPAFYSIVADLFPkHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIVGL 228
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL---------------GWRGALAVWAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 229 PGVLLALLMILTVREPERKGLKMDAnGVAVKASFKNSIGFIKThrktffchfIGFSFYTMMLYSLLGWAPAYYMRHfGLD 308
Cdd:COG2807 180 LALLALLLWLPLLRRRPAAAAAAPA-AASLRSLWRSPLAWLLT---------LFFGLQSLLYYAVVAWLPPILRDA-GLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 309 ASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdaaiRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFFSTFP 388
Cdd:COG2807 249 AATAGLLL-SLFQLAGIPGSLLVPLLADRLGDR-------RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1872276290 389 IPASAAATQMLTPN-QLRSQVSAKFLLISNLIAlGVGTTAVALITDRY--YENTLMVGNSISIVNAVAGVI 456
Cdd:COG2807 321 FPLALTLIGLRARTpAEAAALSGMAQSVGYLLA-ALGPLLVGALHDATgsWTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
52-387 |
3.25e-17 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 82.99 E-value: 3.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 52 VIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQfsllQGLAFSLF---YAFMGVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTD----QGLVLSSFfwgYALTQVLGGYLADRFGGKKVLLLAVALWSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 129 ATAACGL--SKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGgyvigllkdvs 206
Cdd:cd17380 77 ATLLTPLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIG----------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 207 fvtlPVIGEIKTWQLTFMIVGLPGVLLALLMILTVReperkglkmdangvAVKAsfknsigFIKTHrktfFCHfiGFSFY 286
Cdd:cd17380 146 ----PLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP--------------PVWA-------IIVAH----FCM--NWGFY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 287 TmmlysLLGWAPAYYMRHFGLDASqtGYILGSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAgAIGCAALIIPSV--- 363
Cdd:cd17380 195 I-----LLSWLPTYFHEVLVPLAK--GWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRK-LMQSIGFLGPALfll 266
|
330 340
....*....|....*....|....
gi 1872276290 364 LFTQVDNMQLSFALIFVAMFFSTF 387
Cdd:cd17380 267 LLSHTDSFSLALLCMSVALGLSAF 290
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
59-435 |
4.88e-17 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 82.42 E-value: 4.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 59 YILSFVDRQILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKN 138
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLL-LSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 139 FIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDvsfvtlpvigeikt 218
Cdd:TIGR00881 83 LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS-------------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 219 WQLTFMIVGLPGVLLALLMILTVRE-PERKGL----------KMDANGVAVKASFKNSIGFIKTHRKTFFCHF-IGFSFY 286
Cdd:TIGR00881 149 WHWVFIVPGIIAIIVSLICFLLLRDsPQSCGLppaeempneePDGDAEKKEEELTKKQIFLQYVLLNKVLWYIsLGYVFV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 287 TMMLYSLLGWAPAYYM--RHFGLDASQTGYILgsiILVANTSGALFCGWLID-FFSKRGYSDAAIRAGAIGCAALIIpSV 363
Cdd:TIGR00881 229 YVVRTGILDWSPLYLTqeKGFSKEKASWAFTL---YELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVY-WL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1872276290 364 LFTQVDNMQLSFAliFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNLIALGVGtTAVALITDRY 435
Cdd:TIGR00881 305 NPAANPLMDLICL--FALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAG-LPLGYLADGF 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
56-461 |
5.62e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.14 E-value: 5.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 56 MVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQgLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGL 135
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVV-NAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 136 SKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGyvigllkdvsfvtlpVIGE 215
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGG---------------LLLE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 216 IKTWQLTFmIVGLPGVLLALLMILTVReperkglkmdangVAVKASFknsigfikthrktffchFIGFSFYTMMLYSllg 295
Cdd:cd17321 146 LFGWRWIF-LINVPIGLVALLLARTFS-------------GAVLAAF-----------------LLGAALGGLLFLL--- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 296 waPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALiipsVLFTQVDNMQLSF 375
Cdd:cd17321 192 --PLYLQGVLGYSPLQAGLAL-LPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL----ALLGADSSVWLLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 376 ALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNL-IALGV---GTTAVALITDRYYENTLMVGNSISIVNA 451
Cdd:cd17321 265 PGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLgGALGVallGALLTAGLSANLGDSGVAALLSAAAAAF 344
|
410
....*....|
gi 1872276290 452 VAGVIGVFLL 461
Cdd:cd17321 345 AAGFHLAFLV 354
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
96-410 |
3.59e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.84 E-value: 3.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 96 SLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGR 175
Cdd:cd17473 45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 176 ALGVYAIGAFIGSGLAFLIGGYVIGLlkdvsfvtlpvigeikTWQLTFMIVGLpGVLLALLMILTVREPERKGLKMDANG 255
Cdd:cd17473 125 MLGLQSAAMSLGGVVFLLLGGALAEI----------------GWRAPFLVYLL-ALPVLILVLLFLPEPARKSKSAASPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 256 VAVKASFKN-SIGFIkthrktFFCHFIGFS-FYTMMLYSllgwapAYYMRHFGL-DASQTGYILgSIILVANTSGALFCG 332
Cdd:cd17473 188 AATAAALPWkRVLPI------YFLAFLAMLlFYVIPIQL------PFLLQERGGgSAALIGLAL-AIASLAGAIGALLFG 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1872276290 333 WLidffsKRGYSDAAIRAGAIGCAALIIpsVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSA 410
Cdd:cd17473 255 RL-----KRRLGKRRLLAIGFALMALGF--LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
93-462 |
7.34e-15 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 76.08 E-value: 7.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 93 LAFSLF---YAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFP 169
Cdd:cd17320 38 LTLSAYllgFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 170 KHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVREPerkgL 249
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFF---------------GWRAIFVFLALLGLLLLLLVLLFLPET----L 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 250 KMDANGVAVKASFKNSIGFIKTHRKTFFCHFIGFSFytMMLYSLLGWAPAYYMRHFGLDASQTGYILGSIILvANTSGAL 329
Cdd:cd17320 179 PEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSF--AGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAI-ALILGSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 330 FCGWLIDFFSKRgysdAAIRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPN-QLRSQV 408
Cdd:cd17320 256 LNGRLVRRFGPR----RLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFpHVAGTA 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 409 SAKFLLISNLIAlGVGTTAVALITDRYyentlmvGNSISIVNAVAGVIGVFLLY 462
Cdd:cd17320 332 SALLGFLQFLIG-ALAGALVGLLPNGT-------ALPMGLLILVLGLLALLLLI 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
83-460 |
3.49e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 73.80 E-value: 3.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 83 SDTQFSLLQgLAFSLFYAFMGVPIAALADKKSRVKIISV-----GIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALS 157
Cdd:cd06173 32 SALLVGLVL-AAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 158 PAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIVGLpGVLLALLM 237
Cdd:cd06173 111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL---------------GPGGAFAINAL-SFLLSALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 238 ILTVREPERKGLKMDANgvAVKASFKNSIGFIKTHRKTFFCHFIG--FSFYTMMLYSLLgwaPAYYMRHFGLDASQTGYI 315
Cdd:cd06173 175 LLFIRRPPPAAPGESSS--LLLRDLREGLRYLRRSPLLRLLLLALalFALLGGALTVLL---PLLAKEVLGGGAAGYGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 316 LGSiILVANTSGALFCGWLIDFFSKRgysdaaiRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAA 395
Cdd:cd06173 250 LAA-FGVGALLGALLLGRLSKRRRRG-------RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1872276290 396 TQMLTPNQLRSQVSAkFLLISNLIALGVGTTAVALITDRYyentlmvgnSISIVNAVAGVIGVFL 460
Cdd:cd06173 322 LQLRVPDELRGRVFS-VYNALNSGAMPLGALLAGLLADAL---------GLSAVFLLAGALLLLA 376
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
68-462 |
4.69e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 73.36 E-value: 4.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 68 ILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARL 147
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLL-VSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 148 SVGAGEAALSPAFYSIVADLFPKhKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFvtlpvigeiktwqLTFMIVG 227
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGL-------------LILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 228 LPGVLLALLMILTVREPERKGLKMDANGVAVKASFKNSIGFIkthrktffchFIGFSFYTMMLYSLLGWAPAYYMRHfGL 307
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLL----------LIIVFLRSWVLSSLTTFLPFYLVQR-GY 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 308 DASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdAAIRAGAIGCAALIIPSVLFTQVdnmqLSFALIFVAMFFSTF 387
Cdd:cd17478 228 SLVFAGLLL-SLFLFAGAIGTLIGGPLSDRFGRR----RVIIASLLLAAPFLLLFLLTPGI----WSYILLVLAGFLLFA 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1872276290 388 PIPASAAATQMLTPNQlRSQVSAKFLLISNLIAlGVGTTAVALITDRYYENTLMvgnsisIVNAVAGVIGVFLLY 462
Cdd:cd17478 299 SFPVTVVLAQELLPGN-VGLASGLMMGLSFGLG-GIGAPVLGALADAFGLESVL------LILALLPLLGALLAF 365
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
52-402 |
3.79e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 70.31 E-value: 3.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 52 VIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLAFsLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATA 131
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAAL-FGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 132 ACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIgllkdvsfvtlP 211
Cdd:cd17365 80 LTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI-----------P 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 212 VIGeiktWQLTFMIVGLPGVLLALLMILTVreperkglkmdangvavkasfknsigfikthrKTFFCHFIGFsfytMMLY 291
Cdd:cd17365 149 AFG----WRSVFLLGGVPPLILLPLLRGTL--------------------------------LLWVTFFMGL----LLVY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 292 SLLGWAPaYYMRHFGLDASQTGyILGSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIipsvlftqvdNM 371
Cdd:cd17365 189 LLNSWLP-KLMVEAGYSLSQAL-TITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLG----------VS 256
|
330 340 350
....*....|....*....|....*....|.
gi 1872276290 372 QLSFALIFVAMFFSTFPIPASAAATQMLTPN 402
Cdd:cd17365 257 PASLVLLYVLVFLAGACVNGAQVGLYALAAR 287
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
48-435 |
1.26e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.22 E-value: 1.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 48 QWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLAFsLFYAFMGVPIAALADKKSRVKIISVGIAFWS 127
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGL-LAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 128 LATAACGLSKNFIQMFLAR-LSVGAGEAALSPAFYSIVADLFPKHKLGRALGVyaigAFIGSGLAFLIGGYVIGLLkdvs 206
Cdd:cd17355 80 AGLVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI----LTAGGGLGSLVFLPLGAAL---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 207 fvtlpviGEIKTWQLTFMIVGLPGVLLALLMIL-TVREPERKGLKMDA------NGVAVKASFKNsigfikthrKTFFCH 279
Cdd:cd17355 152 -------IEAFGWRTALLVLALLALLVLVPVLLlLRRRPADLALRAYDdaspasPGSTLKEALRS---------ASFWLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 280 FIGFSFYTMMLYSLLGWAPAyYMRHFGLDASQTGYILGsIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALI 359
Cdd:cd17355 216 ALAFFLCGFAVVGLIVHLVP-YLADRGISPAAAAVALA-LIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLL 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1872276290 360 IPSVLFTQVdnmqLSFALIFVAMFFSTFPIPASAAATQMltpnQLRSQVSA-KFLLISNLIALGVGTTAVALITDRY 435
Cdd:cd17355 294 LLPFPPLAL----LLFAALFGLGWGATVPLTAALAARYF----GARSYGTLfGLVFAPHQLGSALGPWLGGLLYDRT 362
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-431 |
2.78e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 67.99 E-value: 2.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 55 CMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQgLAFSLFYAFMgVPIAA-LADKKSRVKIISVGIAFWSLATAAC 133
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVI-TSYLLALAIM-IPLSGwLADRFGTRRLFLTALALFTLGSLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 134 GLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIgllkdvsfvtlpvi 213
Cdd:cd17503 79 GLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT-------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 214 gEIKTWQLTFMIVGLPGVLLALLM-ILTVReperkglkmdangvavkaSFKNsigfikthrKTFFCHFIGFSFYTMMLYS 292
Cdd:cd17503 145 -DNLSWRWIFYINLPIGILALLLApLLDLR------------------LFKD---------RNFTLGLLLSFLLGLGLFG 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 293 LLGWAPAYYMRHFGLDASQTGYILGSIILVAnTSGALFCGWLIDffsKRGYSDAAIRAGAIGCAALIIPSVLFTQVDNMQ 372
Cdd:cd17503 197 AMFLLPLYLQNVLGYSAFESGLVLAPGGLAS-AILSPLVGRLLD---KFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWL 272
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1872276290 373 LSFALIFVAMFFSTFPIPASAAATQMLtPNQLRSQVSAKFLLISNLiALGVGTTAVALI 431
Cdd:cd17503 273 IILPLFIRGLGMGLVFMPLNTLALNSL-PPEQIGDATALFNTIRQL-GGSIGTALLATL 329
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
118-394 |
9.17e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 9.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 118 IISVGIAFWSLATA-ACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKL-GRALGVYAIGAFIGSGLAFLIG 195
Cdd:COG2211 88 AIPLALSFVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLP 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 196 GYVIGLLKDvsfvtlpviGEIKTWQLTFMIVGLPGVLLALLMILTVREPERKglkmdangVAVKASFKNSIGFIKTHRkT 275
Cdd:COG2211 168 PPLVAAFGG---------DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP--------EEEKVSLKESLKALLKNR-P 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 276 FFCHFIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGyILGSIILVANTSGALFCGWLIDFFSKRgysdAAIRAGAIGC 355
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVG-LLLALYFLAALLGAPLWPRLAKRFGKK----KAFIIGLLLA 304
|
250 260 270
....*....|....*....|....*....|....*....
gi 1872276290 356 AALIIpSVLFTQVDNMQLSFALIFVAMFFSTFPIPASAA 394
Cdd:COG2211 305 ALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
57-385 |
1.31e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 63.04 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 57 VAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLS 136
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLL-VAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 137 -KNFIQMFLARLSVGAGEAALSPAFYSIVAdLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFVTLpvige 215
Cdd:cd17341 85 vSSYWGLLVLGFLLGFAGANFASGQPWASF-WFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVG----- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 216 iktWQLTFMIVGLPGVLLALLMILTVREPERKGLKMDANGVAVKASFKNsigfiktHRKTFFCHFIGFSFYTMMLYSLlg 295
Cdd:cd17341 159 ---WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKN-------YRTWILSLLYGVTFGSFVGFSN-- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 296 WAPAYYMRHFGLDASQTGYILGSIILvANTSGALFCGWLIDFFSKRGySDAAIRAGAIGCAALIIPSvLFTQVDNMQLSF 375
Cdd:cd17341 227 VLPTYFKTRFGLPLVTAGILAALFPL-AGALARPAGGWLSDRFGGRR-RLWWLFIVMTIGAALLSLS-LPTSGTNLVLFL 303
|
330
....*....|
gi 1872276290 376 ALIFVAMFFS 385
Cdd:cd17341 304 ALFVALGLGA 313
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
82-374 |
2.22e-10 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 62.26 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 82 LSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSkNFiqMFLARLSVGAGEAALSPAFY 161
Cdd:cd17336 35 LSSSQSGLILS-ANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLLALP-HF--LFVGQFLLGIGSSPLYTLGI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 162 SIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFVTLPVIGE----IKTWQLTFMIVGLPGVLLALLM 237
Cdd:cd17336 111 TYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLGITPDdprwIGAWWLGFLILGILLLIVSIPL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 238 ILtvreperkglkmdangvavkasFKnsigfikthrKTFFCHFIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILG 317
Cdd:cd17336 191 FF----------------------FP----------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTG 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1872276290 318 SIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPSVLFTQVDNMQLS 374
Cdd:cd17336 239 LILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIA 295
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
52-199 |
7.42e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 60.67 E-value: 7.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 52 VIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATA 131
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSL-FVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1872276290 132 ACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVI 199
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFIT 147
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
49-359 |
3.28e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 58.80 E-value: 3.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 49 WYVVIICMVAYILSFVDRQILSL-MIEPIKADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAFWS 127
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNaAVMGMKEDLKLVGNQYNWGNTV-FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 128 LATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGgyvIGLLKdvsf 207
Cdd:cd17327 83 LLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLA---YGVFK---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 208 vtLPVIGEIKTWQLTFMIVGLPGVLLALLMILTVREPERKGL-------KMDANGVAVKASFKNSIGFIKTHRKTFFCHF 280
Cdd:cd17327 156 --ILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWflteeekELAVERLRANQTGKGDQKFKWKQIKEAFKDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 281 IgfsFYTMMLYSLLGWAP--AYYMRHFGLDASQTGYILGSIILVANTS-----GALFCGWLIDFFSKRG-YSDAAIRAGA 352
Cdd:cd17327 234 R---TWLLFLFFFCSQITnnGISNFLPLILKSLGFYSLQTNLLSVPIGalgavSLLIAALLSDRFKKRGlFAIFACVLAL 310
|
....*..
gi 1872276290 353 IGCAALI 359
Cdd:cd17327 311 VGSIILL 317
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
79-461 |
7.92e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.22 E-value: 7.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 79 DLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSP 158
Cdd:cd17489 25 DLGGSEAVAGLVVGL-FTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 159 AFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLkdvSFVTLpvigeiktwqltfMIVGLPGVLLALLMI 238
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL---GFAVL-------------FIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 239 LTVREPERKGlkmDANGVAVKASFKNSIgfikthRKTFFCHFIGFSFYTMMLYSLLGWAPAYYMRHFgldASQTGYILgS 318
Cdd:cd17489 168 FLVKDPPPVA---AEEAEAGTRAFRRLV------EKKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFF-T 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 319 IILVANTSGALFCGWLIDFFSKRGysdAAIRAGAIGCAALIIpsVLFTQVDNMQLSFALIFVAMFFSTFpiPASAAATQM 398
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKT---VIIPGLLLLALGLLL--LSFAGSPWMLLLAAVLYGLGFGLLF--PALQALAVD 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 399 LTPNQLRSQVSAKFlLISNLIALGVGTTAVALITDRY-YENTLMVGnsiSIVNAVAGVIGVFLL 461
Cdd:cd17489 308 LVPPHRRGAANGTF-FIFFDLGIGLGGLLLGLVAELFgYRAMFLLA---AVVVLLALVLYIFLL 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
46-202 |
1.74e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 46 SYQWYVVIICMVAyiLSFVDRQILSLMIepikADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAF 125
Cdd:cd17370 201 AFWLYLLAVALFA--LGNFSFAFLILRA----QELGLSAALIPLLYAL-FNLVYALAAYPAGRLSDRIGRKKLLILGYLS 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1872276290 126 WSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAigafIGSGLAFLIGGYVIGLL 202
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFN----TVVGIGWLLASLIAGYL 346
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
92-430 |
1.83e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 57.24 E-value: 1.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 92 GLAFSLFYAFMGVPIAALADK--KSRV----KIISVGIafwSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVA 165
Cdd:PRK08633 53 NALFLLPFLLLSSPAGFLADKfsKNRVirivKLFEVGL---TLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAKYGIIP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 166 DLFPKHKLGRALGVyaIGAFigSGLAFLIGGYVIGLLKDVSFVTLPVIGEIKTWQLTFMIVGLpgVLLALLMILTVR--- 242
Cdd:PRK08633 130 ELVGKENLSRANGL--LEAF--TIVAILAGTALFSFLFESVNGNTPSEILGRIAPAGLVLLAV--AVLGLIFAYRLPkvp 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 243 --EPERKGLKMDANGVAVKASFKNsigfIKTHRKTFFChFIGFSFYTMMLYSLLGWAPAYYMRHFGL-DASQTGYILG-S 318
Cdd:PRK08633 204 aaAPEVFDKKKYLFPKLLWRNLKL----LRSDRVLWLA-IIGLSYFWFISQLAQANFPAYAKEVLGLdNTFQVQYLLAaS 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 319 IILVAntSGALFCGWLidffSKRGYSDAAIRAGAIGCAaliIPSVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQM 398
Cdd:PRK08633 279 AIGIG--IGSLLAGRL----SGRHIELGLVPLGALGLA---LSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQF 349
|
330 340 350
....*....|....*....|....*....|....*
gi 1872276290 399 LTPNQLRSQVSAKFLLISN---LIALGVGTTAVAL 430
Cdd:PRK08633 350 RAPEKELGKVLAANNFLQNvgmLLFLALTTLFSGL 384
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
100-372 |
1.95e-08 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 56.44 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 100 AFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLsKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGV 179
Cdd:pfam03137 50 LLLIVFVSYFGGKGHRPRWIGVGALLMGLGSLLFAL-PHFLSFFLGQLLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 180 YAIGAFIGSGLAFLIGGYVIGLLKDVSFVTLPVIGEIKTWQ----LTFMIVGLPGVLLALLMIL-------TVREPERKG 248
Cdd:pfam03137 129 LYAVRVLGPALGFLLGSLCLRIYVDIGKVSITLTPKDPRWVgawwLGFLIAGLLLLLTAIPFFFfpkslpgAAKRRAKKK 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 249 LKMDANGVAVKASFKNSIGFIKTHR------------KTFFCHFIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYIL 316
Cdd:pfam03137 209 KEPHSQDIADLKKTKSLKKLGPSLKdfpkalkrllknPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLT 288
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1872276290 317 GSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPSVLFTQVDNMQ 372
Cdd:pfam03137 289 GVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSP 344
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
109-432 |
3.50e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 55.26 E-value: 3.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 109 LADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGS 188
Cdd:cd17502 53 LSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIAS 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 189 GLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIvGLPGVLLALLMILTVreperkglkmdangvavkaSFKNSIGF 268
Cdd:cd17502 133 VAGPLIGGAFTDHL---------------SWRWCFYI-NLPIGGLALALLRTI-------------------LLSSIFGF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 269 ikthrktffchFIGFSFYTMMLYSllgwaPAYYMRHFGLDASQTGYILGSIILvANTSGALFCGWLIdffSKRGYSDAAI 348
Cdd:cd17502 178 -----------LFGGALFGLIYYL-----PLYFQLVLGDSATKSGVRLLPLII-GLVIGSIISGALI---SKTGRYKPLI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 349 RAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAKFLLISNL-IALGVGTTA 427
Cdd:cd17502 238 VIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLgGTLGVAITD 317
|
....*
gi 1872276290 428 VALIT 432
Cdd:cd17502 318 VFLVA 322
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
51-191 |
8.40e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 51 VVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLAT 130
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLL-LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1872276290 131 AACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLA 191
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
56-247 |
1.10e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 56 MVAYILSFVDRQILSLMIEP-IKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACG 134
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYyFKYVLGLSAALVGLL-LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 135 LSK--NFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKL-------GRALGVYAIGAFIGSGLAFLIGGYVIGLlkdV 205
Cdd:COG2211 313 FLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLAL---F 389
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1872276290 206 SFVTLPVIGEIKTWQLTFMIVGLPGVLLALLMILTVREPERK 247
Cdd:COG2211 390 GYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTR 431
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
48-237 |
1.55e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 53.55 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 48 QWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLAFSLFYaFMGVPIAALADKKSRVKIISVGIAFWS 127
Cdd:PRK03893 18 QWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRW-FGGLLLGAMGDRYGRRLAMVISIVLFS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 128 LATAACGLSKNFIQMFLARLSVG---AGEAALSPAFysiVADLFPKHKLGRALGvyaigafigsglaFLIGGYVIG--LL 202
Cdd:PRK03893 97 VGTLACGFAPGYWTLFIARLVIGmgmAGEYGSSATY---VIESWPKHLRNKASG-------------FLISGFSIGavVA 160
|
170 180 190
....*....|....*....|....*....|....*
gi 1872276290 203 KDVSFVTLPVIGeiktWQLTFMIvGLPGVLLALLM 237
Cdd:PRK03893 161 AQVYSLVVPVWG----WRALFFI-GILPIIFALWL 190
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
52-341 |
1.90e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 53.04 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 52 VIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFsllqGLAFS------LFYAFMGvpiAALADKKSRVKIISVGIAF 125
Cdd:PRK11551 17 IGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQM----GWAFSagilglLPGALLG---GRLADRIGRKRILIVSVAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 126 WSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGgyvigllkdv 205
Cdd:PRK11551 90 FGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIG---------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 206 sfvtlPVIGEIKTWQLTFMIVGL-PGVLLALLMILTvrePERKGLKMDANGVAVKASFKNSIgFIKTHRKTFFCHFIGFS 284
Cdd:PRK11551 160 -----VLAAGDAAWRHIFYVGGVgPLLLVPLLMRWL---PESRAFAQAAGAGKQRAPVLRAL-FGEGRATATLLLWISYF 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1872276290 285 FYTMMLYSLLGWAPAyYMRHFGLDASQTGYI-----LGSIIlvantsGALFCGWLIDFFSKR 341
Cdd:PRK11551 231 FTLIVLYFLLNWLPS-LLVGQGLSRSQAGLVqiafnIGGAL------GSLLIGALMDRLRPR 285
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
94-462 |
2.93e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.56 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 94 AFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKL 173
Cdd:cd17477 39 AYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 174 GRALGVYAigafIGSGLAFLIGGYVIGLLKDVSFVTLPVIGeiktwqlTFMIVGLPGVLLALLMILTVREPERKGLK--M 251
Cdd:cd17477 119 GRVLGLYS----TVLGLGFALGPLLLALVGTAGALPFLIAA-------VLLLLALVPLLLTRRAAPEIEEAESISLRrlL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 252 DANGVAVKASFknSIGFIKThrktffchfigfSFYTMMlysllgwapAYYMRHFGLDASQTGYILgSIILVANTSGALFC 331
Cdd:cd17477 188 RIAPLALLGAF--VAGFLEG------------AFYSLL---------PLYGLRLGLSVAQAALLL-AAFVLGGLLLQWPL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 332 GWLIDFFSKRgysdaaiRAGAIGCAALIIPSVLFTQVDNMQLSFALIFV---AMFFSTFPIpASAAATQMLTPNQLrSQV 408
Cdd:cd17477 244 GWLADRFDRR-------RVLLGCALLGALAALLLPLVPGLPLALLVLLFlwgGAAGPLYTL-ALALAGDRLPGDEL-VAA 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 409 SAKFLLISNLIALgVGTTAVALITDRYYENTLMVgnsisivnAVAGVIGVFLLY 462
Cdd:cd17477 315 NAALLLLYGLGSV-IGPLLAGALMDAFGPHGLFL--------FLAAVALLFLLF 359
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
109-236 |
4.41e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.81 E-value: 4.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 109 LADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALsPAFYSIVADLFPKHKLGRALGVYAIGAFIGS 188
Cdd:cd17504 54 LGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGA 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1872276290 189 GLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIVGLPGVLLALL 236
Cdd:cd17504 133 GIGLPLGGWIVQHL---------------GWRWIFWTAAPVAVLLAAL 165
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
48-461 |
4.92e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 51.51 E-value: 4.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 48 QWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWS 127
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGII-GSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 128 LATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKdvsf 207
Cdd:cd17312 80 LANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 208 vtlpvigeiktWQLTFMIVGLPGVLLALLMILTVReperkglkmDANGVAVKASFknSIGFIKTHRktffchfigfsfyt 287
Cdd:cd17312 156 -----------WRAAFLVPGIVGLVVAIILFFFLR---------DSPPYVWVLSL--AYAFVYIVR-------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 288 mmlYSLLGWAPAYYMRHFGLDASQTGYILgSIILVANTSGALFCGWLID-FFSKRGYSDAAIragaIGCAALIIPSVLFT 366
Cdd:cd17312 200 ---YACLDWGPLYLYEVKGYSLIDAGWFS-SLYEVGGIAGTILAGLLSDkLFGGRRAPIAVI----YMLLMTLSLALFWF 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 367 QVDNMQLSFALIFVAMFFSTFPIPA-SAAATQMLTPNQLRSQVSAKFLLISNLIAlGVGTTAVALITDRYYentlmvGNS 445
Cdd:cd17312 272 FPHNKLLSIVLLFLIGFFVGGPINLiGGAAAQDIGRKEAAGTATGFVGLFGYLGA-SLAGLPLGYIIDHYG------WST 344
|
410
....*....|....*.
gi 1872276290 446 ISIVNAVAGVIGVFLL 461
Cdd:cd17312 345 VFYFLISAALLSVLLL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
51-214 |
5.80e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.66 E-value: 5.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 51 VVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKK-SRVKIISVGIAFWSLA 129
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL-FGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 130 TAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFVT 209
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
....*
gi 1872276290 210 LPVIG 214
Cdd:cd06174 364 LVLAV 368
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
89-387 |
1.13e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 50.68 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 89 LLQGLA---FSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGeaALSPAFYSIVA 165
Cdd:cd17472 32 TLIGLAlgiYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 166 DLFPKHKLGRALGVyaIGAFIgsGLAFLIgGYVIGllkdvsfvtlPVIGEIKTWQLTFMIVGLPGVLLALLMILTVREPE 245
Cdd:cd17472 110 DLTREENRTKAMAL--IGASI--GIAFAI-SMVLG----------PLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 246 RKglkmdangVAVKASFKNSIGFIKTHRKTFFCHFIGF--SFYTMMLYSLLgwapAYYMRHFGLDASQTGYILGSIILVA 323
Cdd:cd17472 175 KI--------VQISEKEKKKLKKLLKNKRLLRLDFSIFilHFVLMAFFYIL----PLLLTQLGGGKGQLWKVYLPAILIG 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 324 NTSGALFcgwlIDFFSKRGYSDAAIRAGAIGCAALIIpSVLFTQVDNMQLSFALIFvamFFSTF 387
Cdd:cd17472 243 FILMVPF----VIYAEKKGKMKQVFVSSILLIAVGFL-LLLFAATSLWLLIIGLII---FFIGF 298
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-202 |
1.36e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 49 WYVVIICMVAYILSFVdrqILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd06173 211 RLLLLALALFALLGGA---LTVLLPLLAKEVLGGGAAGYGLLLA-AFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 129 ATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLL 202
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
|
| MFS_SLCO4_OATP4 |
cd17403 |
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ... |
49-342 |
1.47e-06 |
|
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340961 [Multi-domain] Cd Length: 420 Bit Score: 50.33 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 49 WYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd17403 3 GFLFFLCIFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIAS-SYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 129 ATAACGLSKnFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFV 208
Cdd:cd17403 82 GSLVFALPH-FTVFILAQLLHGAGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 209 TLPVI------GEIKTWQLTFMIVGLPGVLLALLMiltvreperkglkmdangvavkasfknsIGFikthRKTFFCHFIG 282
Cdd:cd17403 161 DSELGltpddpRWVGAWWLGFLISGALALIIAFPL----------------------------LGF----PPTFMFLNLA 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 283 FSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILGSIILVANTSGALFCGWLIDFFSKRG 342
Cdd:cd17403 209 GASEGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKC 268
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
56-434 |
1.53e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.95 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 56 MVAYILSFVDRQILSLMIEP---IKADLMLSDTQFSLLQG---LAFSLFYAFMGvpiaALADKKSRVKIISVGIAFWSLA 129
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVIlpiIGDSFGTSPNQLSWLAAsysLTVGTFILIFG----RLGDIYGHKKMFVIGSFWFAIW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 130 TAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLgRALGVYAIGAfiGSGLAFLIGGYVIGLlkdvsfvt 209
Cdd:cd17476 77 SLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPR-KNIVFSLFGA--TAPLGFALGGVFGGL-------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 210 lpvIGEIKTWQLTFMIVGLPGVLLALLMIltvreperkglkmdangvavkasfknsigFIKTHRKTFFCHFIGFSFYTMM 289
Cdd:cd17476 146 ---FAQLAWWPWIFWFLAILAAIVAVAAI-----------------------------FWTSPSFIAVLLAVFLGWASFG 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 290 LYSLLGWAPAYYMRHFGLdasqtgyILGSIILVANTSGALFCGWLIDFFSKRGYSDAAIragAIGCAALIIPSVLFTQVD 369
Cdd:cd17476 194 IWVFYATQYFQNVRGYSP-------LLTSARFIPMAIGGVLAAITVGFLIARLPPSYIM---AISMVAFLVGPILFATMP 263
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1872276290 370 NMQLSFALIFVAMFFSTF-PIPASAAATQMLTPNQLRSQ------VSAKFLLISNLIALGVGTTAVALITDR 434
Cdd:cd17476 264 VHQTYWAQAFPAMIVAPFgMDFSFPAATIIASNAVPREYqglagsLVNTVVNYGISIGLGIAGTVETSVNED 335
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
92-246 |
1.98e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 92 GLAFSLFYAFM--GVPIAA-LADK--KSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVAD 166
Cdd:COG2271 219 GLLLSLPFLAGivGSLLGGwLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 167 LFPKHKLGRALGVYAIGAFIGSGLafliGGYVIGLLKDVSfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVREPER 246
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGAL----GPLLVGYLLDAT-----------GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
76-389 |
3.68e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 48.84 E-value: 3.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 76 IKADLMLSDTQFSLLQGLAfSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLS-KNFIQMFLARLSVGAGEA 154
Cdd:TIGR00886 28 IKDDLGLSTAQLGNLVAVP-VLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 155 ALSPAFYSIvADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFVTLPVIGeikTWQLTFMIVGLPGVLLA 234
Cdd:TIGR00886 107 SFASCMPWI-SFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAW---GWAFVIVPAGILLLPAL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 235 LLMILTVREPERKGLKMDANGVAVKASFKNSIGFIKThrKTFFCHFIGFSFYTMMLysllgwaPAYYMRHFGLDASQTGY 314
Cdd:TIGR00886 183 LIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILA--LLYSVTFGSFLGVSSIF-------AMLFKDQFGLSKVQAGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 315 ---ILGSIILVANTSGalfcGWLIDFFSKRgYSDAAIRAGAIGCAALiipsVLFTQVDNMQLS-FALIFVAMFF------ 384
Cdd:TIGR00886 254 yasLGGFLGSLARPAG----GAISDRLGGA-RKLLMNFLGVAMGAFL----VVLGLVSDGSLAaFIVLFVALFFfagagn 324
|
....*.
gi 1872276290 385 -STFPI 389
Cdd:TIGR00886 325 gSTFAL 330
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
76-384 |
4.07e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.77 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 76 IKADLMLSDTQFSLLQGlAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAA 155
Cdd:cd17475 22 LQEDLHLSLAQVGLLLS-ALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 156 LSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIggyvigllkdvsfvtLPVIGEIKTWQLTFMIVGLPGVLLAL 235
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL---------------LPPLALHYGWRAAFVVAGLVSILAAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 236 LMILTVREPERKGLKmdangVAVKASFKNSIGFIKTHRKTFFCHFIGFsFYTMMLYSLLGWAPAYYMRHFGLDASQTGYI 315
Cdd:cd17475 166 LFWLFYREPPAASAA-----TESASTLLRSLKEVLRNRDVWLIAIAGA-LLVAPQFALLTFLLLFLHDHLGLSVVAAGAL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1872276290 316 LgSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPSVLfTQVDNMQLSFALIFVAMFF 384
Cdd:cd17475 240 L-AVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLL-SPGTPLWLLVLLLILLGLF 306
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
83-336 |
4.63e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 49.00 E-value: 4.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 83 SDTQFSLLQGLAFsLFYAFMGVPIAALADKKSRVK-IISVGIAFWSLATAACGL-SKNFIQMFLARLSVGAGEAALSPAF 160
Cdd:COG2270 50 ATALWGYALAIAG-LLVALLAPVLGAIADRSGRKKpFLAFFTLLGVLATAALFFvAPGGLWLGLLLFVLANIGFEGSLVF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 161 Y-SIVADLFPKHKLGR--ALGvYAIGaFIGSGLAFLIggYVIGLLKDVSFvtlPVIGEIKTWQLTFMIVGLPGVLLALLM 237
Cdd:COG2270 129 YnAFLPDIATPEEIGRvsGLG-WALG-YLGGVLLLLI--NLALFLKPEAF---GLPDAGEAVRISFLLTALWWLLFALPL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 238 ILTVREPERKGLKmdANGVAVKASFK---NSIGFIKTHRKTFFcHFIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQtgy 314
Cdd:COG2270 202 FLFLPERPRPGPA--PPRGAVRAGFRelrRTLRELRRYRDLLR-FLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTE--- 275
|
250 260
....*....|....*....|....*
gi 1872276290 315 iLGSIILVANTS---GALFCGWLID 336
Cdd:COG2270 276 -LIVFGLLVQIVaalGALLFGRLDD 299
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
49-404 |
5.14e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 5.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 49 WYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLAFSLfYAFMGVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGV-SLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 129 ATAACGLSKNFIQMFLAR-LSVGAGEAALSPAFYSIVADLFpKHKLGRALGVyaigAFIGSGlaflIGGYVIGLLKDVSF 207
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGI----AVAGSG----VGTFVFPPLLRYLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 208 vtlpvigEIKTWQLTFMIVG---LPGVLLALLMILtvreperkglkmdangvavkasFKNsigfikthrKTFFCHFIGFS 284
Cdd:cd17352 152 -------DNYGWRGALLILGglcLNLCVCGLLLRL----------------------LKD---------PTFVLLALGVS 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 285 FYTMMLYSLLGWAPAYYMRHfGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPsvL 364
Cdd:cd17352 194 FAMLGFFVPFVYLPSYAKSL-GIDESDAAFLL-SIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFP--L 269
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1872276290 365 FTqvDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQL 404
Cdd:cd17352 270 AT--TYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKL 307
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-239 |
8.44e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 8.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 51 VVIICMVAYILSFVdrqilsLMIEPIKADLMLSDTQF--SLLQGLAFSLFyaFMGVPIAA-----LADKKSRVKIISVGI 123
Cdd:cd17473 199 VLPIYFLAFLAMLL------FYVIPIQLPFLLQERGGgsAALIGLALAIA--SLAGAIGAllfgrLKRRLGKRRLLAIGF 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 124 AFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLK 203
Cdd:cd17473 271 ALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
170 180 190
....*....|....*....|....*....|....*.
gi 1872276290 204 DVSFVtlpvigeiktwqltFMIVGLPGVLLALLMIL 239
Cdd:cd17473 351 GLSGA--------------FLILGVLALVLAIVLLL 372
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
76-377 |
9.69e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 9.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 76 IKADLMLSDTQFSLLQGLAFSLFYAFMGV--PI-AALADKKSRVKII---SVGIAfwsLATAACGLSKNFIQMFLARLSV 149
Cdd:cd17391 23 IEQLGVTSGGLVELWSGLAFSSTFLVSAIfsPIwGRLADRYGRKPMLlraSLGMA---IVIGLMAFVTNVWQLLILRLLQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 150 GAgEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKdvsfvtlpvigeiktWQLTFMIVGLP 229
Cdd:cd17391 100 GV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFG---------------IRNVFFITGGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 230 GVLLALLMILTVRE---PERKglKMDANGVAVKASFKNSIGFIKTHRKTFFCHFIGFSFYTMMlysllgwapAYYMRHFG 306
Cdd:cd17391 164 LFLAFLLTLFFVKEdfkPVEK--KKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPIL---------TLYIRQLM 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1872276290 307 LDASQTGYILGSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPSVLFTQVDNMQLSFAL 377
Cdd:cd17391 233 GDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLL 303
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
108-387 |
1.70e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 108 ALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIG 187
Cdd:cd17329 57 RLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 188 sglaFLIGGYVIGLLKDVSFVTLpvigeiktwqltFMIVGLPGVLLALLMILTVrePERKGLKMDANGVAVKASFKnsig 267
Cdd:cd17329 137 ----VAIGPLLGGLLLLYSFRLL------------FLAAAVLFLLAALVLLFLL--PETRPKRRAAEKTEILRGYK---- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 268 fIKTHRKTFFCHFIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYIL---GSIILVANTsgalfcgwLIDFFSKRGYS 344
Cdd:cd17329 195 -IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLalnALLIVLLQF--------PVARLVERFRL 265
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1872276290 345 DAAIRAGAIGCAALIIPSVLFTqvdnmqlSFALIFVAMFFSTF 387
Cdd:cd17329 266 RKILMIGILLFAIGFAVLAFAN-------TLAVLILAMIVLTL 301
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
48-384 |
2.10e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 46.85 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 48 QWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLqGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWS 127
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLI-GSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 128 LATAACG----LSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLK 203
Cdd:cd17345 80 IINILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 204 DvsfvtlpvigeiKTWQLTFMIVGLPGVLLALLMILTVRE-PERKGL----------------KMDANGVAVKASFKNsi 266
Cdd:cd17345 160 D------------GWWRGAFIFPAIIAIIVAVIVLFLGKDtPESEGLppieeykgdypeeadgEEEEQELSAWEIFVK-- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 267 gFIKTHRKTFFCHFIGFSFYtMMLYSLLGWAPAYYMRHFGLDASQTGyILGSIILVANTSGALFCGWLID--FFSKRGys 344
Cdd:cd17345 226 -YVLKNKLLWYIAIANVFVY-LVRYGILDWAPTYLSEVKGFSKAQAM-WAFSLFEWAAIPGTLLAGWLSDklFKGRRA-- 300
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1872276290 345 daaiRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFF 384
Cdd:cd17345 301 ----PTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFL 336
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
169-356 |
2.92e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 46.34 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 169 PKHKLGRALGVYAIgafigsglAFLIGGYVIGLLkdVSFVTLPVIGEIKTwqltfMIVGLPGVLL-ALLMILTVREPERK 247
Cdd:cd17337 119 PAERLGSAVGWFWF--------AFTGGLPVLGSY--LASFTIPVIGEIGT-----LWLSLVFVALgGLIALFLVRDRTGE 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 248 GlKMDANGVAVKASFKNSIGFIKTHRKTFFCHFI-------GFSFYTMMlysllgwaPAYYMRHFGLDASQTGYILGsII 320
Cdd:cd17337 184 Q-PLANPSEEPLKELLSGITILFRNPKIAIGGIVriintlsQFGFPVFM--------PLYFTDTGGFSTSQWLQIWG-II 253
|
170 180 190
....*....|....*....|....*....|....*.
gi 1872276290 321 LVANTSGALFCGWLIDffsKRGYSDAAIRAGAIGCA 356
Cdd:cd17337 254 FLVNIFFNLIFGILGD---KIGWRRTVRWFGGVGCA 286
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
90-254 |
5.65e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 45.50 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 90 LQGLAFSLF---YAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKN--FIQMFLARLSVGAGEAALSPAFYSIV 164
Cdd:TIGR00894 77 LQGLILSSHfygQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGggIALVVFCRVIQGLAQGSVSPATHKII 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 165 ADLFPKHKLGRALGVYAIGAFIGSglafLIGGYVIGLLKDVSFVtlpvigeiktWQLTFMIVGLPGVLLALLMILTVREP 244
Cdd:TIGR00894 157 VKWAPPKERSRLLGMSTSGFQLGT----FIFLPISGWLCESWGG----------WPMIFYVFGIVGCAWSLLWFVFPADD 222
|
170
....*....|
gi 1872276290 245 ERKGLKMDAN 254
Cdd:TIGR00894 223 PSIHPCISKF 232
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
88-378 |
2.31e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.34 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 88 SLLQGLAFSLFY--AFMGVPIAA-LADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIV 164
Cdd:cd17317 24 DWLVALVQTIFFlgVLIGSLLFGyLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 165 ADLFPKHKlgRALGVYAIGAFIGSGLAFLIGGYVIgllkdvsfvtlpvigeIKTWQLTFMIVGLPGVLLALLMILtvrep 244
Cdd:cd17317 104 MEIVGPKY--RSFVGILFGLFWALGYMLLALLAYL----------------IRDWRWLQLAISLPGLLFLLLLWW----- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 245 erkglkmdangvavkasfknsigfikTHRKTFFCHFIGFSfyTMMLYsllgWAPAYYMRHFGLDASQTGYILGSIILVAn 324
Cdd:cd17317 161 --------------------------LPRRTIIVGLIWFV--TSLVY----YGLSLNSSNLGGNLYLNFFLSGLVEIPA- 207
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 325 tsgALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIipsVLFTQVDNMQLSFALI 378
Cdd:cd17317 208 ---YFLALLLLDRLGRRWTLSGSLLLAGLACLVTA---LLPDDENTLALTLALV 255
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
109-339 |
2.72e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 109 LADK-KSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYA----IG 183
Cdd:cd17370 57 LSDRtGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRaldtLG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 184 AFIGSGLAFLIGGYVIGllkdvsfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVREPERKglkmdaNGVAVKASFK 263
Cdd:cd17370 137 AVLGPLLAALLLYLLGG-----------------NYRTIFLLAAIPALLALLILLFVVKEYPRP------PKLRKKSKKT 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 264 NSIGFIKTHRK-TFFCHFIGFSFYTMMLYSL--------LGWAPAYYMRHFGLDASqTGYILGSIILVANTSGALFCGWL 334
Cdd:cd17370 194 SLKKLPKAFWLyLLAVALFALGNFSFAFLILraqelglsAALIPLLYALFNLVYAL-AAYPAGRLSDRIGRKKLLILGYL 272
|
....*
gi 1872276290 335 IDFFS 339
Cdd:cd17370 273 SLALA 277
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
87-236 |
3.54e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 87 FSLLQGLAFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFySIVAD 166
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ-AYIAD 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1872276290 167 LFPKHKLGRALGVyaIGAFigSGLAFLIGGYVIGLLKDVSFVTLP--VIGEIKTWQLTFMIVGLPGVLLALL 236
Cdd:cd17330 114 ITDEEERAKAFGI--ISAA--FGLGFILGPALGGFLSTPYGYALPflVAAALALLNLVLVLFFLPPLRRLLL 181
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
48-199 |
4.40e-04 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 42.79 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 48 QWYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAFWS 127
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDI-YSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1872276290 128 LATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLF--PKHKlGRALGVYAigAFIGSGLAF--LIGGYVI 199
Cdd:PRK14995 83 LASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFteEKQR-NMALGVWA--AVGSGGAAFgpLVGGILL 155
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
109-322 |
6.78e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.82 E-value: 6.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 109 LADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGS 188
Cdd:PRK11102 49 MADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 189 GLAFLIGGYVIGLLkdvsfvtlpvigeikTWQLTFMIVGLPGVLLALLMILTVRE---PERKglkmdangvaVKASFKNS 265
Cdd:PRK11102 129 LLAPIIGGWLLVWF---------------SWHAIFWVLALAAILAAALVFFFIPEtlpKERR----------QPFHLRTT 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1872276290 266 IG-FIK--THRKTFFCHFI-GFSFYTMmlYSLLGWAPAYYMRHFGLDASQTGYILGSIILV 322
Cdd:PRK11102 184 IRnFASlfRHKRVLGYMLAsGFSFAGM--FSFLTAGPFVYIELNGVSPQNFGYYFALNIVF 242
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-209 |
1.03e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.48 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 54 ICMVAYILSFVDrQILSLMIEPIKA----DLMLSDTQFSLLQGLAFS-------LFYAFMGvpiaALADKKSRVKIISVG 122
Cdd:cd17391 202 LLISLFVTTFII-QLANQSIEPILTlyirQLMGDASNLAFISGLVFSatgvsslLSAPRLG----KLGDRIGHHRILLGA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 123 IAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLL 202
Cdd:cd17391 277 LLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHF 356
|
....*....
gi 1872276290 203 --KDVSFVT 209
Cdd:cd17391 357 gyRAVFVVT 365
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-388 |
1.39e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.06 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 49 WYVVIICMVAYILSFVDRQILSLMIEPIKADLMLSDTQFSLLQGLaFSLFYAFMGVPIAALADKKSRVKIISVGIAFWSL 128
Cdd:cd17353 2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTL-TIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 129 ATAACGLSKNFIQMFLAR---LSVGAGEAALSPAfySIVADLFPkHKLGRALGVyAIGAFigsGLAFLIGGYVIGLLKDV 205
Cdd:cd17353 81 GFILSAFAISLPLLFLGYgvlGGIGAGIGYITPV--STAVKWFP-DKRGLATGI-VIAGF---GLGSLIFSPLIAYLINT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 206 SFVtlpvigeiktwQLTFMIVGL-PGVLLALLMILTVREPERKGLKMDANGVAVKASFKNSIGFIKTHR-KTFFCHFIGF 283
Cdd:cd17353 154 VGV-----------PTTFLILGIiFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRtPTFWLLWLMF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 284 SFYTMMLYSLLGWAPAYYMRHFGLDAsQTGYILGSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALI-IPS 362
Cdd:cd17353 223 FLNATAGLMLIGQAKPIGQEFAGLDA-GIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPfIGS 301
|
330 340
....*....|....*....|....*...
gi 1872276290 363 VLFTQVdnmqLSFALIFVAM--FFSTFP 388
Cdd:cd17353 302 VAVLFV----LGVALIGFCYggGFALFP 325
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
104-398 |
1.75e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 104 VPIAALADKKSRVKI-ISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGeAALSPAFYSIVADLFPKHKLGRALGVYAI 182
Cdd:cd17490 49 IPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 183 GAFIGSGLAFLIGGyvigllkdvsfvtlpVIGEIKTWQLTFmIVGLPGVLLALLMILTVREPERKGLKMDANGVAVKASF 262
Cdd:cd17490 128 VNNLGQLIAFLIGG---------------LIAEHFGMRAPF-LLAALAGVLGFILSLFIKEERREKKPVLTELKELLSVL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 263 KN----SIGFIkthrkTFFCHFIGFSfyTMMLYSLLgwapayYMRHFGLDASQTGyILGSIILVANTSGALFCGWLidFF 338
Cdd:cd17490 192 KDkkllFFSLL-----AILQQMITFS--TTFGFTPL------IAKQLGASSFQLG-LLSIIYLLPNALASLLSGTL--FY 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1872276290 339 SKRG-YSDAAIRAGAIGCAALIIPSV------LFTQVDNmQLSFALIF-VAMFFSTFPIPASAAATQM 398
Cdd:cd17490 256 KKLGeRNTIIIGFLLLGAYCFLIPFApnltllYLLQALN-GFGTGILFpLLMSLSIEGVPAEQRSTAM 322
|
|
| MFS_SLCO5_OATP5 |
cd17404 |
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ... |
112-338 |
1.90e-03 |
|
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340962 [Multi-domain] Cd Length: 425 Bit Score: 40.41 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 112 KKSRVKIISVGIAFWSLATAACGLSKNFIqmfLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGV-YAIGAFiGSGL 190
Cdd:cd17404 64 RGHRPRWIAVGGVLIALGSFLFSLPHFFI---LAQILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAImYVMGAL-GPAA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 191 AFLIGGYVIGLLKDvSFVTLPVIGE-----IKTWQLTFMIVGLPGVLLALLMIltvreperkglkmdangvavkaSFKns 265
Cdd:cd17404 140 GFLLGGLLINFYVD-PLSTPPDISPgdprwIGAWWGGFLLCGIALLLVAFPFF----------------------TFP-- 194
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1872276290 266 igfikthRKTFFCHFIGFSFYTMMLYSLLGWAPAYYMRHFGLDASQTGYILGSIILVANTSGALFCGWLIDFF 338
Cdd:cd17404 195 -------KMTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRF 260
|
|
| oat |
TIGR00805 |
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ... |
139-344 |
3.14e-03 |
|
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.
Pssm-ID: 273279 [Multi-domain] Cd Length: 632 Bit Score: 40.10 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 139 FIQMFLARLSVGAGEAALSPAFYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFVTLPVIGE--- 215
Cdd:TIGR00805 171 WLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIItpt 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 216 ----IKTWQLTFMIVGLPGVLLALLMILTVREPERKGLKMDANGV---AVKASFKNSIGFIKTHRKTFFCH--------- 279
Cdd:TIGR00805 251 dprwIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHeaeKLEKSRGEDRKKNSGITKDFPKFikrllcnki 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 280 --------------FIG-FSFYTMMLYSLLGWAPAY---YMRHFGLDASQTGYILGSII---LVANTSGALFCGWLIDFF 338
Cdd:TIGR00805 331 ymlvilaqvidvlaFNGyITFLPKYLENQYGISSAEanlLIGVVNVPPIGLGYLIGGFImkkFKLNVKKAAYFAICLSTL 410
|
....*.
gi 1872276290 339 SKRGYS 344
Cdd:TIGR00805 411 EYLLYS 416
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
280-463 |
3.73e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 280 FIGFSFYTMMLYSLLGWAPAYyMRHFGLDASQTGYILgSIILVANTSGALFCGWLIDFFSKRgysdaaiRAGAIGCAALI 359
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVV-TAYLLGAALGAPLAGRLADRFGRR-------RVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 360 IPSVLFTQVDNMQLSFALIFVAMFFSTFPIPASAAATQMLTPNQLRSQVSAkFLLISNLIALGVGTTAVALITDRYYENT 439
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALG-LLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|....
gi 1872276290 440 LMvgnsisIVNAVAGVIGVFLLYK 463
Cdd:COG2814 166 VF------LVNAVLALLALLLLLR 183
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
93-430 |
3.90e-03 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 39.95 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 93 LAFSLFYAFMGvpiaALADK--KS----RVKIISVGIAfwslATAACGLS-KNFIQMFLARLSVGAGEAALSPAFYSIVA 165
Cdd:PRK06814 63 LPFFIFSALAG----QLADKydKAklakILKFAEIGIA----ALAIYGFHlNSVPLLFAALFLMGIHSALFGPIKYSILP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 166 DLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGLLKDVSFVTLPVIGEIKTWqltfmivglpgvlLALLMILTVREPE 245
Cdd:PRK06814 135 DHLNKDELLGANALVEAGTFIAILLGTIIGGLATISGNFVILVALLMGIAVLGW-------------LASLFIPKTGNAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 246 RkGLKMDANgvaVKASFKNSIGFIKTHRKTFFCHFIGFSFYTM--MLYSLLgwaPAYYMRHFGLDASQTGYILgSIILVA 323
Cdd:PRK06814 202 P-DLKIDRN---IIRSTITLLKYAKADKRIWLAILGISWFWLVgaVVLSQL---PLLAKETLGGDENVATLFL-AVFSVG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 324 NTSGALFCGWLID--------FFSKRGYSDA------AIRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAMFFSTFPI 389
Cdd:PRK06814 274 VAVGSFLASKLSEgritllyvPIGALLMGLFgldlafASSSVPAEPAQLKSILVFLSKRHGWRILIDLFGLAAAGGLYIV 353
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1872276290 390 PaSAAATQMLTPNQLRSQV-------SAKF-----LLISNLIALGVGTTAVAL 430
Cdd:PRK06814 354 P-LFAALQAWANPAHRARViaannvlNAAFmvagtIILALLQALGFSIPWIIL 405
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
85-213 |
6.26e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.75 E-value: 6.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 85 TQFSLLQGLAFSLFYAFMGVPI---AALADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAgEAALSPAFY 161
Cdd:PRK09874 50 SALNMWSGLVFSITFLFSAIASpfwGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNAN 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 162 SIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYVIGL--LKDVSFVTLPVI 213
Cdd:PRK09874 129 ALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSygLRPVFFITASVL 182
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
80-247 |
6.63e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 80 LMLSDTQFSLLQ-GLAFSLFYA--FMGVPIAALADKKSRV-KIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAA 155
Cdd:cd06180 24 LMLAELGLSYAQaGWIATANYAgyLVGALLASFLRRRGRArRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 156 LSPAFYSIVADLFPKHKLGRALGVYaigaFIGSGLAFLIGGYVIgllkdvsfvtLPVIGEIKTWQLTFMIVGLPGVLLAL 235
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLL----FAGVGLGIALSGLLV----------PAGLGGGLSWRAGWLALALLSAVLLL 169
|
170
....*....|..
gi 1872276290 236 LMILTVREPERK 247
Cdd:cd06180 170 LSFLLLRRGPSA 181
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
160-390 |
8.36e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.38 E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 160 FYSIVADLFPKHKLGRALGVYAIGAFIGSGLAFLIGGYviglLKDVSFVTLPVIGEIKtwqLTFMIVGLPGVLLALLMIL 239
Cdd:cd17313 126 VRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAI----LWDHNWFGFALGGNLK---VPFYIGAIILLVCVLVTLF 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 240 TVREPERKGLKMDANGVAVKASFKNSIGFI-----KTHRKTFFCHFIGF-SFYTMMLYSLLGWAPAYYMrhfGLDASQTG 313
Cdd:cd17313 199 FVKEPPLSPEAGEHSENPSLGEVLKSLLKLlkimpRSLLRLLLVIFFWWiAFFPFELFFTDYMGEEVYH---GTSAASSH 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 314 YIL----GSIILVANTSGALFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVaMFFSTFPI 389
Cdd:cd17313 276 YGAgvrmGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGI-GWATININ 354
|
.
gi 1872276290 390 P 390
Cdd:cd17313 355 P 355
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
95-382 |
8.53e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 95 FSLFYAFMGVPIAA--LADKKSRVKIISVGIAFWSLATAACGLSKNFIQMFLARLSVGAGEAALSPAFYSIVADLFPkHK 172
Cdd:cd17333 38 SSQNAGYLIGSLLAgfLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ES 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 173 LGRALGVyaIGAFIGSGLafLIGGYVIGLLKDVSFVtlpvigeiktWQLTFMIVGLPGVLLALLMILTVREPERKGLKMD 252
Cdd:cd17333 117 SATRLNV--LHGFFGLGA--LIGPLIATSLLTSELS----------WSWAYLIIGLIYLLLAILILLTLFPELPSARNPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872276290 253 ANGVAVKASFKnsigfikthRKTFFCHFIGFSFYTMM----LYSLLGWAPAYYMRHFGLDASQTGYILGSIilvanTSGA 328
Cdd:cd17333 183 QSVGAFSASAS---------RLLRNPSIILGALALFLyvgaETAFSSWVPSYLVEKKHVSDGLAGYLLSGF-----WVGI 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1872276290 329 LFCGWLIDFFSKRGYSDAAIRAGAIGCAALIIPSVLFTQVDNMQLSFALIFVAM 382
Cdd:cd17333 249 TIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM 302
|
|
| |
