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Conserved domains on  [gi|1864593970|ref|WP_176786746|]
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MULTISPECIES: SdiA-regulated domain-containing protein, partial [Salmonella]

Protein Classification

esterase-like activity of phytase family protein( domain architecture ID 1904650)

esterase-like activity of phytase family protein contains a domain that may exhibit esterase activity and have a beta-propeller structure

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SdiA-regulated super family cl42058
SdiA-regulated; This model represents a bacterial family of proteins that may be regulated by ...
 2-112 6.60e-50

SdiA-regulated; This model represents a bacterial family of proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators. The C-terminal domain included in the alignment forms a five-bladed beta-propeller structure. The X-ray structure of Escherichia coli yjiK (C-terminal domain) exhibits binding of calcium ions (Ca++) in what appears to be an evolutionarily conserved site. Sequence analysis suggests a distant relationship to proteins that are characterized as containing NHL-repeats. The latter also form beta-propeller structures, with several examples known to form six-bladed beta-propellers. Several of the six-bladed beta-propellers containing NHL repeats have been characterized functionally, including members with enzymatic functions that are dependent on metal ions. No functional characterization is available for this family of five-bladed propellers, though.


The actual alignment was detected with superfamily member pfam06977:

Pssm-ID: 477930  Cd Length: 249  Bit Score: 158.20  E-value: 6.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   2 EKEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCI 81
Cdd:pfam06977  15 AKPIAGIEDNLSGLTYNPDTRTLFAVTNKPPELVELSLEGDVLRRIPLDGFKDPEAIEYIGDGRYAISDERDQALYVVQV 94

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1864593970  82 DSSTTVLPPAT-YSLTLDVNRhSDNAGFEGLA 112
Cdd:pfam06977  95 DDDTTVLDIADaRKLSLGINE-AGNKGFEGLA 125
 
Name Accession Description Interval E-value
SdiA-regulated pfam06977
SdiA-regulated; This family represents a conserved region approximately within a number of ...
 2-112 6.60e-50

SdiA-regulated; This family represents a conserved region approximately within a number of hypothetical bacterial proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators. Some family members contain the pfam01436 repeat.


Pssm-ID: 429226  Cd Length: 249  Bit Score: 158.20  E-value: 6.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   2 EKEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCI 81
Cdd:pfam06977  15 AKPIAGIEDNLSGLTYNPDTRTLFAVTNKPPELVELSLEGDVLRRIPLDGFKDPEAIEYIGDGRYAISDERDQALYVVQV 94

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1864593970  82 DSSTTVLPPAT-YSLTLDVNRhSDNAGFEGLA 112
Cdd:pfam06977  95 DDDTTVLDIADaRKLSLGINE-AGNKGFEGLA 125
SdiA-regulated cd09971
SdiA-regulated; This model represents a bacterial family of proteins that may be regulated by ...
 3-112 1.56e-42

SdiA-regulated; This model represents a bacterial family of proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators. The C-terminal domain included in the alignment forms a five-bladed beta-propeller structure. The X-ray structure of Escherichia coli yjiK (C-terminal domain) exhibits binding of calcium ions (Ca++) in what appears to be an evolutionarily conserved site. Sequence analysis suggests a distant relationship to proteins that are characterized as containing NHL-repeats. The latter also form beta-propeller structures, with several examples known to form six-bladed beta-propellers. Several of the six-bladed beta-propellers containing NHL repeats have been characterized functionally, including members with enzymatic functions that are dependent on metal ions. No functional characterization is available for this family of five-bladed propellers, though.


Pssm-ID: 197380 [Multi-domain]  Cd Length: 242  Bit Score: 139.29  E-value: 1.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   3 KEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCID 82
Cdd:cd09971     8 KPIGGILDELSGLTYNPDTDTLFAVTNKPPALVELSKDGDVLRRIPLDGFSDPEGITYLGDGQFAIVDERLQALLIVYVD 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1864593970  83 SSTTVLPPATY-SLTLDVNrHSDNAGFEGLA 112
Cdd:cd09971    88 GDTTSLDAADAqSITLGFT-EKGNKGFEGIA 117
YjiK COG3204
Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];
3-112 3.48e-37

Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];


Pssm-ID: 442437 [Multi-domain]  Cd Length: 271  Bit Score: 126.24  E-value: 3.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   3 KEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCID 82
Cdd:COG3204    42 KLLPGELDEISGLTYNPDTGTLFAVQDEPGEIFELSLTGKVLRRIPLGGFGDYEGIAYLGDGRYVLVSEGTQTLYEVTLD 121

                          90       100       110
                  ....*....|....*....|....*....|
gi 1864593970  83 SSTTVLPPATYSLTLDVNrHSDNAGFEGLA 112
Cdd:COG3204   122 DGTTVLRADVKSLKLGLS-EKGNKGFEGLA 150
 
Name Accession Description Interval E-value
SdiA-regulated pfam06977
SdiA-regulated; This family represents a conserved region approximately within a number of ...
 2-112 6.60e-50

SdiA-regulated; This family represents a conserved region approximately within a number of hypothetical bacterial proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators. Some family members contain the pfam01436 repeat.


Pssm-ID: 429226  Cd Length: 249  Bit Score: 158.20  E-value: 6.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   2 EKEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCI 81
Cdd:pfam06977  15 AKPIAGIEDNLSGLTYNPDTRTLFAVTNKPPELVELSLEGDVLRRIPLDGFKDPEAIEYIGDGRYAISDERDQALYVVQV 94

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1864593970  82 DSSTTVLPPAT-YSLTLDVNRhSDNAGFEGLA 112
Cdd:pfam06977  95 DDDTTVLDIADaRKLSLGINE-AGNKGFEGLA 125
SdiA-regulated cd09971
SdiA-regulated; This model represents a bacterial family of proteins that may be regulated by ...
 3-112 1.56e-42

SdiA-regulated; This model represents a bacterial family of proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators. The C-terminal domain included in the alignment forms a five-bladed beta-propeller structure. The X-ray structure of Escherichia coli yjiK (C-terminal domain) exhibits binding of calcium ions (Ca++) in what appears to be an evolutionarily conserved site. Sequence analysis suggests a distant relationship to proteins that are characterized as containing NHL-repeats. The latter also form beta-propeller structures, with several examples known to form six-bladed beta-propellers. Several of the six-bladed beta-propellers containing NHL repeats have been characterized functionally, including members with enzymatic functions that are dependent on metal ions. No functional characterization is available for this family of five-bladed propellers, though.


Pssm-ID: 197380 [Multi-domain]  Cd Length: 242  Bit Score: 139.29  E-value: 1.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   3 KEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCID 82
Cdd:cd09971     8 KPIGGILDELSGLTYNPDTDTLFAVTNKPPALVELSKDGDVLRRIPLDGFSDPEGITYLGDGQFAIVDERLQALLIVYVD 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1864593970  83 SSTTVLPPATY-SLTLDVNrHSDNAGFEGLA 112
Cdd:cd09971    88 GDTTSLDAADAqSITLGFT-EKGNKGFEGIA 117
YjiK COG3204
Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];
3-112 3.48e-37

Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];


Pssm-ID: 442437 [Multi-domain]  Cd Length: 271  Bit Score: 126.24  E-value: 3.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970   3 KEITGIHGGLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIEYLGGNRYALSRERERTLTTHCID 82
Cdd:COG3204    42 KLLPGELDEISGLTYNPDTGTLFAVQDEPGEIFELSLTGKVLRRIPLGGFGDYEGIAYLGDGRYVLVSEGTQTLYEVTLD 121

                          90       100       110
                  ....*....|....*....|....*....|
gi 1864593970  83 SSTTVLPPATYSLTLDVNrHSDNAGFEGLA 112
Cdd:COG3204   122 DGTTVLRADVKSLKLGLS-EKGNKGFEGLA 150
Phytase-like pfam13449
Esterase-like activity of phytase; This is a repeated domain that carries several highly ...
 10-112 5.10e-05

Esterase-like activity of phytase; This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.


Pssm-ID: 433217 [Multi-domain]  Cd Length: 284  Bit Score: 40.73  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864593970  10 GGLSGLTWNPDSRTLFAVTD----HPSSVVELDTEG--------NVLRVIP---SDGDH------DFEAIEYLGGNRYAL 68
Cdd:pfam13449   4 GGLSGLAYDPDDGRFYAVSDdgskNPARFYTLDIDLdgdgiggvEITGVTPlrdPDGAPfpprglDPEGIAVAPDGTFWV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1864593970  69 SRE-----RERTLTTHCIDSSTtvLPPATYSLTLDVNRHSDNAGFEGLA 112
Cdd:pfam13449  84 SSEggpfiLRFDLDGRLLRELP--LPADFLPDPSPDAGLRRNKGFEGLA 130
YjiK COG3204
Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];
11-59 2.87e-04

Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];


Pssm-ID: 442437 [Multi-domain]  Cd Length: 271  Bit Score: 38.41  E-value: 2.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1864593970  11 GLSGLTWNPDSRTLFAVTDHPSSVVELDTEGNVLRVIPSDGDHDFEAIE 59
Cdd:COG3204   192 DPSALAIDPITGHLLILSDESKLLLELDRDGKVVSALSLDKGFDFPQPE 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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