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Conserved domains on  [gi|1863109674|ref|WP_176548905.1|]
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cell wall-active antibiotics response protein LiaF

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LiaF super family cl44125
Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system ...
 1-85 7.25e-33

Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4758:

Pssm-ID: 443791 [Multi-domain]  Cd Length: 235  Bit Score: 113.09  E-value: 7.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   1 DHIYELEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEE-TGFNRNVT 79
Cdd:COG4758   127 SEPYEWEDINIQGGIGDTTIDLTKAILPKGETVIVIRGLIGDVRILVPYDVEVSVHHSVIIGDVKIFDQEEdGGINESLH 206


                  ....*.
gi 1863109674  80 FRTEQY 85
Cdd:COG4758   207 YETEGY 212
 
Name Accession Description Interval E-value
LiaF COG4758
Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system ...
 1-85 7.25e-33

Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system [Signal transduction mechanisms];


Pssm-ID: 443791 [Multi-domain]  Cd Length: 235  Bit Score: 113.09  E-value: 7.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   1 DHIYELEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEE-TGFNRNVT 79
Cdd:COG4758   127 SEPYEWEDINIQGGIGDTTIDLTKAILPKGETVIVIRGLIGDVRILVPYDVEVSVHHSVIIGDVKIFDQEEdGGINESLH 206


                  ....*.
gi 1863109674  80 FRTEQY 85
Cdd:COG4758   207 YETEGY 212
LiaF_C_term NF040535
cell wall-active antibiotics response protein LiaF, C-terminal domain; This HMM represents the ...
 6-85 5.65e-30

cell wall-active antibiotics response protein LiaF, C-terminal domain; This HMM represents the conserved C-terminal domain of LiaF (called VraT in Staphylococcus), an additional key component of the histidine kinase LiaS and response regulator LiaR system. The system responds to cell envelop stress in the Firmicutes, and plays a role in resistance to cell wall-targeting antibiotics.


Pssm-ID: 468527  Cd Length: 104  Bit Score: 101.74  E-value: 5.65e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   6 LEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEE-TGFNRNVTFRTEQ 84
Cdd:NF040535    1 WDDINIQHVIGDTTIDLSKAILPKGENVIVIRGLIGDVKILVPYDVGVSLEASVLYGEVTFFGEEEyDLRNESLKYESPN 80


                  .
gi 1863109674  85 Y 85
Cdd:NF040535   81 Y 81
DUF2154 pfam09922
Cell wall-active antibiotics response 4TMS YvqF; This domain is found in various prokaryotic ...
 1-85 6.24e-29

Cell wall-active antibiotics response 4TMS YvqF; This domain is found in various prokaryotic proteins, including cell wall-active antibiotic response proteins. This entry includes protein product of the yvqF gene, located immediately upstream of vraS. It is associated with glycopeptide resistance in Staphylococcus aureus.


Pssm-ID: 430928  Cd Length: 114  Bit Score: 99.53  E-value: 6.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   1 DHIYELEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEETG-FNRNVT 79
Cdd:pfam09922   9 KDPYELEDINIWRGIGDTTIDLTKAVLPKGETVIVIRGLIGDVKILVPYDVGVSVEASAIFGDVTVFDEKEGGlLNRSVK 88


                  ....*.
gi 1863109674  80 FRTEQY 85
Cdd:pfam09922  89 YESPDY 94
 
Name Accession Description Interval E-value
LiaF COG4758
Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system ...
 1-85 7.25e-33

Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system [Signal transduction mechanisms];


Pssm-ID: 443791 [Multi-domain]  Cd Length: 235  Bit Score: 113.09  E-value: 7.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   1 DHIYELEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEE-TGFNRNVT 79
Cdd:COG4758   127 SEPYEWEDINIQGGIGDTTIDLTKAILPKGETVIVIRGLIGDVRILVPYDVEVSVHHSVIIGDVKIFDQEEdGGINESLH 206


                  ....*.
gi 1863109674  80 FRTEQY 85
Cdd:COG4758   207 YETEGY 212
LiaF_C_term NF040535
cell wall-active antibiotics response protein LiaF, C-terminal domain; This HMM represents the ...
 6-85 5.65e-30

cell wall-active antibiotics response protein LiaF, C-terminal domain; This HMM represents the conserved C-terminal domain of LiaF (called VraT in Staphylococcus), an additional key component of the histidine kinase LiaS and response regulator LiaR system. The system responds to cell envelop stress in the Firmicutes, and plays a role in resistance to cell wall-targeting antibiotics.


Pssm-ID: 468527  Cd Length: 104  Bit Score: 101.74  E-value: 5.65e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   6 LEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEE-TGFNRNVTFRTEQ 84
Cdd:NF040535    1 WDDINIQHVIGDTTIDLSKAILPKGENVIVIRGLIGDVKILVPYDVGVSLEASVLYGEVTFFGEEEyDLRNESLKYESPN 80


                  .
gi 1863109674  85 Y 85
Cdd:NF040535   81 Y 81
DUF2154 pfam09922
Cell wall-active antibiotics response 4TMS YvqF; This domain is found in various prokaryotic ...
 1-85 6.24e-29

Cell wall-active antibiotics response 4TMS YvqF; This domain is found in various prokaryotic proteins, including cell wall-active antibiotic response proteins. This entry includes protein product of the yvqF gene, located immediately upstream of vraS. It is associated with glycopeptide resistance in Staphylococcus aureus.


Pssm-ID: 430928  Cd Length: 114  Bit Score: 99.53  E-value: 6.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863109674   1 DHIYELEDINVQYGACDVEIDLTTAMIPEGETVIVIRGVVGNIRLYVPYDIELSLNHSVIVGRVLLPGHEETG-FNRNVT 79
Cdd:pfam09922   9 KDPYELEDINIWRGIGDTTIDLTKAVLPKGETVIVIRGLIGDVKILVPYDVGVSVEASAIFGDVTVFDEKEGGlLNRSVK 88


                  ....*.
gi 1863109674  80 FRTEQY 85
Cdd:pfam09922  89 YESPDY 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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