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Conserved domains on  [gi|1853294980|ref|WP_174340158|]
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hemolysin III family protein [Enterobacter sp. JMULE2]

Protein Classification

hemolysin III family protein( domain architecture ID 10014977)

hemolysin III family protein, an integral membrane protein that may have hemolytic and cytotoxic activity against a broad range of species and cell types

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK15087 PRK15087
hemolysin; Provisional
1-219 2.09e-132

hemolysin; Provisional


:

Pssm-ID: 185044  Cd Length: 219  Bit Score: 370.96  E-value: 2.09e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980   1 MVSRPIIAQGYSLAEEVANSISHGIGLVFGIVGLVLLLVQAVDTNASAMAITSYSLYGGSMILLFLASTLYHAIPHQRAK 80
Cdd:PRK15087    1 MVQKPLITQGYSLAEEIANSISHGIGLVFGIVGLVLLLVQAVDANADATAITSYSLYGGSMILLFLASTLYHAIPHQRAK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  81 IWLKKFDHCAIYLLIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLA 160
Cdd:PRK15087   81 RWLKKFDHCAIYLLIAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLAFAHRFKVLSLVTYLAMGWLSLIVIYQLA 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294980 161 IKLAVGGVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQV 219
Cdd:PRK15087  161 IKLAIGGVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQA 219
 
Name Accession Description Interval E-value
PRK15087 PRK15087
hemolysin; Provisional
1-219 2.09e-132

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 370.96  E-value: 2.09e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980   1 MVSRPIIAQGYSLAEEVANSISHGIGLVFGIVGLVLLLVQAVDTNASAMAITSYSLYGGSMILLFLASTLYHAIPHQRAK 80
Cdd:PRK15087    1 MVQKPLITQGYSLAEEIANSISHGIGLVFGIVGLVLLLVQAVDANADATAITSYSLYGGSMILLFLASTLYHAIPHQRAK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  81 IWLKKFDHCAIYLLIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLA 160
Cdd:PRK15087   81 RWLKKFDHCAIYLLIAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLAFAHRFKVLSLVTYLAMGWLSLIVIYQLA 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294980 161 IKLAVGGVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQV 219
Cdd:PRK15087  161 IKLAIGGVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQA 219
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
10-216 9.51e-91

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 265.47  E-value: 9.51e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  10 GYSLAEEVANSISHGIGLVFGIVGLVLLLVQAVDTnASAMAITSYSLYGGSMILLFLASTLYHAIPHQRAKIWLKKFDHC 89
Cdd:COG1272     6 PYSRVEEIANAITHGIGALLAIAGLVVLIVLAALS-GDAWAIVSFSIYGASLILLYLASTLYHSLPSPRAKRVLRRLDHS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  90 AIYLLIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLAIKLAVGGVT 169
Cdd:COG1272    85 AIYLLIAGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPAGLW 164
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1853294980 170 LLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYV 216
Cdd:COG1272   165 LLLAGGLLYTVGAVFYALKRLPGFHEIWHLFVLAGSACHFVAILLYV 211
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
15-216 6.31e-72

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 217.19  E-value: 6.31e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  15 EEVANSISHGIGLVFGIVGLVLLLVQAVDTNaSAMAITSYSLYGGSMILLFLASTLYHAIPH-QRAKIWLKKFDHCAIYL 93
Cdd:TIGR01065   1 EEIANAITHGIGAVLSIIALALLVIYSWDHG-GAVAVLGFSIYGISLILLFLVSTLYHSIPKgSKAKNWLRKIDHSMIYV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  94 LIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLAIKLAVGGVTLLAV 173
Cdd:TIGR01065  80 LIAGTYTPFLLLALPGPLGWTVLWIIWGLAIGGIIYKLFFHKRPRWLSLFLYLIMGWLVVLVIKPLYHNLPGAGFSLLAA 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1853294980 174 GGVVYSLGVIFYVCK-RIPYN-HAIWHGFVLGGSVCHFLAIYLYV 216
Cdd:TIGR01065 160 GGLLYTVGAIFYALKwPIPFTyHAIWHLFVLGASACHFVAILFYV 204
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
11-209 3.89e-31

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 113.52  E-value: 3.89e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  11 YSLAEEVANSISHGIGLVFGIVGLVLLLVQAVdTNASAMAITSYSLYGGSMILLFLASTLYH--AIPHQRAKIWLKKFDH 88
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALAT-IDSQLSAVLPFLIFLLSACLCLGCSALYHtfSCHSEKVRKLFRKLDY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  89 CAIYLLIAGTYTPFLLVGL--NSPLSRGLMIVIWSLALLGILFKLTIAHR---FKVLSLVTYLTMGWLSLIVVYQLAIKL 163
Cdd:pfam03006  80 SGIFLLIAGSYTPVIYYAFycAPKLGTIYLSFIWALAILGIISKLLWCFSkpaPRWLRTAVYILMGWSGIIPIAHRALAL 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1853294980 164 AVGG------VTLLAVGGVVYSLGVIFYVCK-----------RIPYNHAIWHGFVLGGSVCHF 209
Cdd:pfam03006 160 GGAGealeiaLVLLVLGGVLYIIGAVFYALRvperlfpgkfdIVGGSHQIFHVFVVLAALCHY 222
 
Name Accession Description Interval E-value
PRK15087 PRK15087
hemolysin; Provisional
1-219 2.09e-132

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 370.96  E-value: 2.09e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980   1 MVSRPIIAQGYSLAEEVANSISHGIGLVFGIVGLVLLLVQAVDTNASAMAITSYSLYGGSMILLFLASTLYHAIPHQRAK 80
Cdd:PRK15087    1 MVQKPLITQGYSLAEEIANSISHGIGLVFGIVGLVLLLVQAVDANADATAITSYSLYGGSMILLFLASTLYHAIPHQRAK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  81 IWLKKFDHCAIYLLIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLA 160
Cdd:PRK15087   81 RWLKKFDHCAIYLLIAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLAFAHRFKVLSLVTYLAMGWLSLIVIYQLA 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294980 161 IKLAVGGVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQV 219
Cdd:PRK15087  161 IKLAIGGVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQA 219
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
10-216 9.51e-91

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 265.47  E-value: 9.51e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  10 GYSLAEEVANSISHGIGLVFGIVGLVLLLVQAVDTnASAMAITSYSLYGGSMILLFLASTLYHAIPHQRAKIWLKKFDHC 89
Cdd:COG1272     6 PYSRVEEIANAITHGIGALLAIAGLVVLIVLAALS-GDAWAIVSFSIYGASLILLYLASTLYHSLPSPRAKRVLRRLDHS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  90 AIYLLIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLAIKLAVGGVT 169
Cdd:COG1272    85 AIYLLIAGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPAGLW 164
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1853294980 170 LLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYV 216
Cdd:COG1272   165 LLLAGGLLYTVGAVFYALKRLPGFHEIWHLFVLAGSACHFVAILLYV 211
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
15-216 6.31e-72

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 217.19  E-value: 6.31e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  15 EEVANSISHGIGLVFGIVGLVLLLVQAVDTNaSAMAITSYSLYGGSMILLFLASTLYHAIPH-QRAKIWLKKFDHCAIYL 93
Cdd:TIGR01065   1 EEIANAITHGIGAVLSIIALALLVIYSWDHG-GAVAVLGFSIYGISLILLFLVSTLYHSIPKgSKAKNWLRKIDHSMIYV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  94 LIAGTYTPFLLVGLNSPLSRGLMIVIWSLALLGILFKLTIAHRFKVLSLVTYLTMGWLSLIVVYQLAIKLAVGGVTLLAV 173
Cdd:TIGR01065  80 LIAGTYTPFLLLALPGPLGWTVLWIIWGLAIGGIIYKLFFHKRPRWLSLFLYLIMGWLVVLVIKPLYHNLPGAGFSLLAA 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1853294980 174 GGVVYSLGVIFYVCK-RIPYN-HAIWHGFVLGGSVCHFLAIYLYV 216
Cdd:TIGR01065 160 GGLLYTVGAIFYALKwPIPFTyHAIWHLFVLGASACHFVAILFYV 204
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
11-209 3.89e-31

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 113.52  E-value: 3.89e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  11 YSLAEEVANSISHGIGLVFGIVGLVLLLVQAVdTNASAMAITSYSLYGGSMILLFLASTLYH--AIPHQRAKIWLKKFDH 88
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALAT-IDSQLSAVLPFLIFLLSACLCLGCSALYHtfSCHSEKVRKLFRKLDY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294980  89 CAIYLLIAGTYTPFLLVGL--NSPLSRGLMIVIWSLALLGILFKLTIAHR---FKVLSLVTYLTMGWLSLIVVYQLAIKL 163
Cdd:pfam03006  80 SGIFLLIAGSYTPVIYYAFycAPKLGTIYLSFIWALAILGIISKLLWCFSkpaPRWLRTAVYILMGWSGIIPIAHRALAL 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1853294980 164 AVGG------VTLLAVGGVVYSLGVIFYVCK-----------RIPYNHAIWHGFVLGGSVCHF 209
Cdd:pfam03006 160 GGAGealeiaLVLLVLGGVLYIIGAVFYALRvperlfpgkfdIVGGSHQIFHVFVVLAALCHY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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