|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
26-414 |
2.93e-82 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 256.34 E-value: 2.93e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 26 RWAIPLSLLACVLLAFFDKISIAALFSDGHFQqamgIDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMA 105
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKD----LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSML 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 106 VWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGW 185
Cdd:cd17319 77 LWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 186 QSTFFVMAMLTVPVLIFVriglrgirldtkpgtsqtsqderraarreLFVSPHFWIICIFNIAFLTYLWGINGWLPGYLI 265
Cdd:cd17319 157 RWAFIIEGLLGLLLAVLW-----------------------------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 266 KGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRV--DKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGT 343
Cdd:cd17319 208 QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1853294965 344 GAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPL 414
Cdd:cd17319 288 ASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-417 |
3.09e-56 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 189.31 E-value: 3.09e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 20 TPEKAVRWAIPLSLLACVLLAFFDKISIAALFsdGHFQQAMGIDfdTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRL 99
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAA--PPLQADLGLS--AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 100 LTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWL 179
Cdd:COG2271 78 LAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 180 LNTFGWQSTFFVMAMLTVPVLIFVriglrgirldtkpgtsqtsqderraarrelfvsphFWIICIFNIAFLTYLWGINGW 259
Cdd:COG2271 158 LAAFGWRAAFLILGLPGLLLALLR-----------------------------------FWLLALAYFLVYFALYGFLTW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 260 LPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKR-AAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFST 338
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294965 339 FMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHsMDSGLIFLAVMAAVGCVLLLPLLRR 417
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRE 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-418 |
1.27e-42 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 153.88 E-value: 1.27e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 24 AVRWAIPLSLLACVLLAFFDKISIAALFsdGHFQQAMGidFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGM 103
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLA--PPLAEEFG--LSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 104 MAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTF 183
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 184 GWQSTFFVMAMLTVPVLIFVRIGLRgirlDTKPGTSQTSQDERRAARrELFVSPHFWIICIFNIAFLTYLWGINGWLPGY 263
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLR----DPPAGAAAAAKASLRDQL-EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 264 LIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGLAAVMHLDTPLTI-IAAMSFSTFMWG 342
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL-LIVFALMALGLLLLALALGSLWLfLVLFLLLGLALG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 343 TGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLLRRY 418
Cdd:COG2223 311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-379 |
6.99e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.02 E-value: 6.99e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 20 TPEKAVRWAIPLSLLACVLLAFFDKISIAALFSDghFQQAMGIDfdTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRL 99
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPL--IAADLGAS--PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 100 LTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWL 179
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 180 LNTFGWQSTFFVMAMLTVPVLIFVRIGLrgirldtkPGTSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGW 259
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLL--------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 260 LPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTF 339
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL-LIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1853294965 340 MWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALS 379
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
62-391 |
3.25e-32 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 125.57 E-value: 3.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:TIGR00881 25 IGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPC 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSL-WLLNTFGWQSTFFVMA--MLTVPVLIFVRI-------GLRGIR 211
Cdd:TIGR00881 105 GRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFIVPGiiAIIVSLICFLLLrdspqscGLPPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 212 LDTKPGTSQTSQDERRAAR------RELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIA 285
Cdd:TIGR00881 185 EMPNEEPDGDAEKKEEELTkkqiflQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 286 MLAGEVIGAWLSDR--VDKRAAACFISMAG---AAIGLAAVMHLDTPLTIIAAMSFSTFmwGTGAPNIFALLA-KATHPR 359
Cdd:TIGR00881 265 GLVGTLLAGWLSDKlfNGRRGPLAVFFMALiivSLLVYWLNPAANPLMDLICLFALGFL--VYGPQMLIGVIAsELAPKK 342
|
330 340 350
....*....|....*....|....*....|..
gi 1853294965 360 VSATAGGIFNGLGNFAGALSPAVMGALIAFTH 391
Cdd:TIGR00881 343 AAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
62-412 |
4.45e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.45 E-value: 4.45e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLL--NTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTKPGTS 219
Cdd:cd06174 106 LALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 220 QTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDR 299
Cdd:cd06174 186 EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 300 VDKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALS 379
Cdd:cd06174 266 LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345
|
330 340 350
....*....|....*....|....*....|...
gi 1853294965 380 PAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd06174 346 PLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
64-418 |
7.68e-29 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 116.51 E-value: 7.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFA 143
Cdd:COG2807 50 LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 144 IVRHNFPQHLqARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRldtkpgtSQTSQ 223
Cdd:COG2807 130 LIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP-------AAAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 224 DERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIkGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKR 303
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 304 AAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVM 383
Cdd:COG2807 281 RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLV 360
|
330 340 350
....*....|....*....|....*....|....*
gi 1853294965 384 GALIAFTHSMDSGLIFLAVMAAVGCVLLLPLLRRY 418
Cdd:COG2807 361 GALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-380 |
2.09e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.36 E-value: 2.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 33 LLACVLLAFFDKISIAALFSDgHFQQAMGIDFDTtrLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMV 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPL-LLAEDLGISPTE--IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 113 AMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVM 192
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 193 AMLTVPVLIFVRIGLRGIRLDTKPGTSQTSQdERRAARRELFVSPHFWIICIFnIAFLTYLWGINGWLPGYlIKGKGIHL 272
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARL-SLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 273 EHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAA--ACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFA 350
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 1853294965 351 LLAKATHPRVSATAGGIFNGLGNFAGALSP 380
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
59-412 |
8.83e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 110.36 E-value: 8.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 59 AMGIDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLF 138
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 139 PLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRgiRLDTKPGT 218
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP--EPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 219 SQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSD 298
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 299 RVDKRAAAcFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGAL 378
Cdd:cd17325 261 RIGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
330 340 350
....*....|....*....|....*....|....
gi 1853294965 379 SPAVMGALIAfTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17325 340 GPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
62-415 |
1.97e-25 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 106.20 E-value: 1.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSvFLSG-LGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPL 140
Cdd:cd17312 33 IGLSKDDLGIIGSAFLIAYAVGK-FISGfLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRgirldTKPgtsq 220
Cdd:cd17312 112 CVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLR-----DSP---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 221 tsqderraarrelfvsPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRV 300
Cdd:cd17312 183 ----------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 301 D--KRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPR--VSATAGGIFNGLGNFAG 376
Cdd:cd17312 247 FggRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRkeAAGTATGFVGLFGYLGA 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 1853294965 377 ALSPAVMGALIAFTHSMdSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd17312 327 SLAGLPLGYIIDHYGWS-TVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
62-336 |
2.20e-25 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 106.94 E-value: 2.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGF----THNYTLMIVLRILLGVAEGPL 137
Cdd:cd17345 33 YGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFvpsaTSSVGLMFILLFLNGWFQGMG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 138 FPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFG---WQSTFFVMAMLTVPVLIFV---------RI 205
Cdd:cd17345 113 WPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVlflgkdtpeSE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 206 GLRGIR--LDTKPGTSQTSQDERRAARRELFV-----SPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWL 278
Cdd:cd17345 193 GLPPIEeyKGDYPEEADGEEEEQELSAWEIFVkyvlkNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWA 272
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 279 SSMPFIAMLAGEVIGAWLSDRVDK--RAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSF 336
Cdd:cd17345 273 FSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIA 332
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
31-412 |
5.11e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 105.32 E-value: 5.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 31 LSLLACVLLAFFDKISIAALFSDghFQQAMGIDfdTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVL 110
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPD--IARDFGVS--VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 111 MVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFF 190
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 191 VMAMLTVPVLIFVRIGLRGIRLDTKPGTSQtsqderRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGI 270
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLGL------LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 271 HLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFA 350
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1853294965 351 LLAKAthPRVSATAGGIFNGLGNFAGALSPAVMGALIAfTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17324 312 VLRLA--PEARGLASSLYLAAYNLGGALGAALGGLVLD-HGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-417 |
2.38e-23 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 99.97 E-value: 2.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 33 LLACVLLAFFDKISIAALfsdGHFQQAMGIDFDTTR--LGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVL 110
Cdd:cd17365 1 LALCFLIIVLDGFDLAVM---GFVAPALAQDWGLSPaqLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 111 MVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFF 190
Cdd:cd17365 78 TLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 191 VMAMLTVPVLIFVRIGLRgirldtkpgtsqtsqderraarrelfvsphFWiICIFNIAFLTYlwGINGWLPgYLIKGKGI 270
Cdd:cd17365 158 LGGVPPLILLPLLRGTLL------------------------------LW-VTFFMGLLLVY--LLNSWLP-KLMVEAGY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 271 HLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAACfISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPN-IF 349
Cdd:cd17365 204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLA-LFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVgLY 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1853294965 350 ALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLLRR 417
Cdd:cd17365 283 ALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
59-410 |
5.42e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 99.55 E-value: 5.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 59 AMGIDFDT--TRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGP 136
Cdd:cd17321 21 TIARDLGAspSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 137 LFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMamltVPVLIFVriglrgirldtkp 216
Cdd:cd17321 101 IMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN----VPIGLVA------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 217 gtsqtsqderraarreLFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWL 296
Cdd:cd17321 164 ----------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 297 SDRVDKRAAAC--FISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNF 374
Cdd:cd17321 228 ADRFGPRLVLVagLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1853294965 375 AGALSPAVMGALI----------------------AFTHSMDSGLIFLAVMAAVGCVL 410
Cdd:cd17321 308 GGALGVALLGALLtaglsanlgdsgvaallsaaaaAFAAGFHLAFLVAAALALLAALL 365
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
31-387 |
1.23e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 95.89 E-value: 1.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 31 LSLLACVLLAFFDKISIAAL-FSDGHFQQAMGIDfdTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCV 109
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMgFAAPAISAEWGLD--PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 110 LMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTF 189
Cdd:TIGR00895 95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 190 FVMAMLTVPVLIFVRIGL-----------------RGIRLDTKPGTSQTS--------QDERRAARRELF------VSPH 238
Cdd:TIGR00895 175 YVGGIAPLLLLLLLMRFLpesidflvskrpetvrrIVNAIAPQMQAEAQSalpeqkstQGTKRSVFKALFqgktarITVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 239 FWIICIFNIAFLtylWGINGWLPgYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGL 318
Cdd:TIGR00895 255 LWLLYFMLLVGV---YFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA-LLLLLGAVFAV 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294965 319 AAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALI 387
Cdd:TIGR00895 330 LVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
63-412 |
1.37e-21 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 94.98 E-value: 1.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAF 142
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 143 AIVRHNFPQHLQARAT----MLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVpVLIFVRIGLrgirldtkpgt 218
Cdd:cd17316 112 TYVAEFAPSKRRGFALgllqSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPAL-LALLLRRRT----------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 219 sqtsqderraarrelfvsphfWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSD 298
Cdd:cd17316 180 ---------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 299 RVD-KRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGA 377
Cdd:cd17316 239 RIGrKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGG 318
|
330 340 350
....*....|....*....|....*....|....*
gi 1853294965 378 LSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17316 319 GAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
33-414 |
6.03e-21 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 93.87 E-value: 6.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 33 LLACVLLAFfdkISIAALFSDGHFQQAMGIDFDTTRLGI--LMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVL 110
Cdd:cd17355 5 LAVTFLILI---LSWGIRYYFGVFIIPIIAEFGWSRAVIslAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 111 MVAMGFTHNYTLMIVLRILLGVA-EGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTF 189
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 190 FVMAMLTVPVLIFVRIGLRGIRLDTKPGTSQTSQDER-RAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIkGK 268
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASpGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 269 GIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGLAAVMHLDTP-LTIIAAMSFSTFMWGTGAPN 347
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL-AASYALRALGLALLLLLPFPpLALLLFAALFGLGWGATVPL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1853294965 348 IFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPL 414
Cdd:cd17355 320 TAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
55-417 |
9.88e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 90.30 E-value: 9.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 55 HFQQAMGIDfdTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAE 134
Cdd:COG0738 33 ALKDAFGLS--DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 135 GPLFPLAFAIVRHNFPQHLQARATML---WLLGTPVGAAIGFPLSLWLLNTfGWQSTFFVMAMLT-VPVLIFVRIGLRGI 210
Cdd:COG0738 111 GLLDVAANPYVAALGPETAASRLNLLhafFSLGALLGPLLGGLLILLGLSL-SWHLPYLILAVLLlLLALLFLRSKLPEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 211 RLDTKPGTSqtsqdeRRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGE 290
Cdd:COG0738 190 EEEEEEAAG------SAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 291 VIGAWLSDRVDkRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKAThPRVSATAGGIFNG 370
Cdd:COG0738 264 FLGGFLLKRFG-PVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLI 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1853294965 371 LGNFAGALSPAVMGALIAFThSMDSGLIFLAVMAAVGCVLLLPLLRR 417
Cdd:COG0738 342 MGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
64-409 |
1.26e-19 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 89.54 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVW--CVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:cd17380 31 WSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWslATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIglrgirldtkpgtsqt 221
Cdd:cd17380 111 TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLI---------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 222 sqderraarrelfVSPHFWIICIFNIAFLTYLWGINGWLPGYLiKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVD 301
Cdd:cd17380 175 -------------YLPPVWAIIVAHFCMNWGFYILLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 302 K--------RAAACFISMAGAAIGLAAVMHLDTPLTII----AAMSFSTFMWGTGAPNiFALLAkathPRVSATAGGIFN 369
Cdd:cd17380 241 SrgwtvtsvRKLMQSIGFLGPALFLLLLSHTDSFSLALlcmsVALGLSAFSSSGVLVN-HQDIA----PNYAGIVFGISN 315
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1853294965 370 GLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCV 409
Cdd:cd17380 316 TAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAV 355
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
65-412 |
4.79e-19 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 88.45 E-value: 4.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 65 DTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAI 144
Cdd:cd17328 32 DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 145 VRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLN-TFGWQSTFFVMAMLTVP----VLIFVRIGLRGIRlDTKPGTS 219
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLlailLLLFVREPPRGAA-EGGVMAK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 220 QTSQDERRAArRELFVSPHFWIICifnIAFLTYLWGING---WLPGYLIKGKGIHL----EHAGWLSSMPFIAMLAGEVI 292
Cdd:cd17328 191 STATSFLADL-KALAKNPSFILST---LGFTAVSFVTGAlafWAPTFFLRAFGVGDlssaDVGLIFGAITCIAGVLGVLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 293 GAWLSDRVDK-----RAAACFISMAGAA--IGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAG 365
Cdd:cd17328 267 GGILADRLRRktpraDPLVCAVGLLAAApfLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTAS 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294965 366 GIFNGLGN-FAGALSPAVMGALIAFTH-----------SMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17328 347 AIQILLSHlLGDAGSPYLIGLISDLLRqnkdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
63-409 |
1.19e-18 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 86.90 E-value: 1.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVW--CVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPL 140
Cdd:cd17318 52 DWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITalLTLLTPLAARGGYGALIVLRILQGLAQGVTFPA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVriglrgirldtkpgtsq 220
Cdd:cd17318 132 MHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW----------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 221 tsqderraarreLFVSPHFWIICIfniAFLTYLWGIN---GWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLS 297
Cdd:cd17318 195 ------------FFLVLPVWAIVV---AHFGHNWGFYtllTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 298 DRVDK---------RAAACFISMAGAAIGLAAVMHL--DTPLTII---AAMSFSTFMWGTGAPNIFALlakatHPRVSAT 363
Cdd:cd17318 260 DWLRSrgilstttvRKLFTSIGFLGPGVFLIALGYLgsNATLAVVfltLSVGLSGACYSGFLVNHLDL-----APNYAGT 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1853294965 364 AGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCV 409
Cdd:cd17318 335 LMGITNTAATIAGIISPLIVGAIVKNDQTIGQWRIVFFISAAIYIL 380
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
63-415 |
1.23e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 86.86 E-value: 1.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGI--LMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAeGPLFPL 140
Cdd:cd17504 25 EFGTSAAAVswVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-GAVFPL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQHLQARAtMLWLLGT-PVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGlrgirldtkpgts 219
Cdd:cd17504 104 AFALVREEFPPERVPVA-QGILSATfGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 220 qtsqDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIhlEHAGWLSSMPFIAMLAGEVIGAWLSDR 299
Cdd:cd17504 170 ----DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGI--TEAGLLLLPGALVMLIAGPLAGRLIAR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 300 VDKRAAAcFISMAGAAIGLAAVM-HLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGAL 378
Cdd:cd17504 244 VGPRRVL-LIGLVISAVGLLLLAlLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAI 322
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1853294965 379 SPAVMGALIA------FTHSMDSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd17504 323 GPAIAGAILTtytvsiTSGGVPTEGAYVLAFLIGAALALAALL 365
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-412 |
1.72e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 86.07 E-value: 1.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 56 FQQAMGIDFdtTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEG 135
Cdd:cd17478 22 LIAKLGLSY--AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 136 PLFPLAFAIVRHNFPqHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTK 215
Cdd:cd17478 100 AFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 216 PGTSQTSQDERRAArrelfVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKgKGIHLEHAGWLSSMPFIAMLAGEVIGAW 295
Cdd:cd17478 179 KAAAKSSARSTLKG-----VWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 296 LSDRVDkRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIfaLLAKATHPRVSATAGGIFNGLGNFA 375
Cdd:cd17478 253 LSDRFG-RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV--VLAQELLPGNVGLASGLMMGLSFGL 329
|
330 340 350
....*....|....*....|....*....|....*..
gi 1853294965 376 GALSPAVMGAlIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17478 330 GGIGAPVLGA-LADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
64-412 |
1.38e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 83.83 E-value: 1.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFA 143
Cdd:cd17475 28 LSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 144 IVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLdtkPGTSQTSQ 223
Cdd:cd17475 108 AIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA---ASAATESA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 224 DERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDK- 302
Cdd:cd17475 185 STLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGg 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 303 RAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGA----PNIFALLAKATHPRVSATAGGIFNGLGNFAGAL 378
Cdd:cd17475 265 RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAigwnGLYLTLVAESAGPEQAGTALGLANTINFIGIAI 344
|
330 340 350
....*....|....*....|....*....|....
gi 1853294965 379 SPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17475 345 GPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
65-412 |
2.23e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.01 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 65 DTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAI 144
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 145 VRHNFpqHLQARATMLWLLGTPVG-AAIGFPLSLWLLNTFGWQSTFFVMAmLTVPVLIFVRIGLRgirldtKPGTSQTSQ 223
Cdd:cd17473 113 IGDYF--EGEERAKMLGLQSAAMSlGGVVFLLLGGALAEIGWRAPFLVYL-LALPVLILVLLFLP------EPARKSKSA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 224 DERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPgYLIKGKGIHLE-HAGWLSSMPFIAMLAGEVIGAWLSDRVDK 302
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLP-FLLQERGGGSAaLIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 303 RAAACfISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAV 382
Cdd:cd17473 263 RRLLA-IGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|
gi 1853294965 383 MGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17473 342 LGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
70-415 |
2.99e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 76.96 E-value: 2.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNF 149
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 150 PQHLQARATMLWLLGTPVGAAIGFPLSLWLL----NTFGWQSTFFVmAMLTVPVLIFVRIGL---------RGIRLDTKP 216
Cdd:cd17371 117 PARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLL-GALPALLVLFIRRFVkeppqwqaaRAARRHFAD 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 217 GTSQTSQDERRAARRELFVSphfwiiCIFNIAFLTYlWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWL 296
Cdd:cd17371 196 RPSLRELFSPPLLRTTLLAS------LLATGALGGY-YGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 297 SDRVDKRAAACFISMaGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPN-IFALLAKATHPRVSATAGGIFNGLGNFA 375
Cdd:cd17371 269 ADRIGRRNNFALFAL-GSAISILLYFFLPLSPTLILILGFPLGFFASGPFSgMGAYLTELFPTAVRATAQGFCYNVGRII 347
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1853294965 376 GALSPAVMGALIafthSMDSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd17371 348 GALFPFLVGFLA----TSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-414 |
1.32e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 74.91 E-value: 1.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 65 DTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAI 144
Cdd:cd17474 32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 145 VRHNFPQHLQARATMLWLLGTPVGAAIGfPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTKPGTSQTSQD 224
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 225 ERRAARRELFVSpHFWIICIFNIAFLTYLwginGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRA 304
Cdd:cd17474 191 LKKALRGRGLLT-FLVSAFLYFFLYFAFL----TYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGAR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 305 AACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMG 384
Cdd:cd17474 266 RILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG 345
|
330 340 350
....*....|....*....|....*....|
gi 1853294965 385 aLIAFTHSMDSGLIFLAVMAAVGCVLLLPL 414
Cdd:cd17474 346 -LLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
38-380 |
2.94e-14 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 73.82 E-value: 2.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 38 LLAFFDKISIAALFSDGhFQQAMGidFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFT 117
Cdd:cd17327 15 FLQYLDKSNISNAAVMG-MKEDLK--LVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 118 HNYTLMIVLRILLGVAEGPLFP-LAFAIVRHNFPQHLQARATMLW---LLGTPVGAAI--GFPLSLWLLNTFGWQSTFFV 191
Cdd:cd17327 92 KNFGGLIALRFFLGLFESGVFPgFILYLGMWYKREEQAKRIAFFYaaaGLGSIFGGLLayGVFKILGVGGLAGWRWLFII 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 192 MAMLTVPVLIFVRIGLRG-----------------IRLDTKPGTSQTSQDERRAArRELFVSPHFWIICIFNIAFLTYLW 254
Cdd:cd17327 172 EGLITIIIGLVIFFWLPDnpskawflteeekelavERLRANQTGKGDQKFKWKQI-KEAFKDPRTWLLFLFFFCSQITNN 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 255 GINGWLPGyLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRA----AACFISMAGAAIGLAAvmhldtplTI 330
Cdd:cd17327 251 GISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGlfaiFACVLALVGSIILLAA--------PN 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1853294965 331 IAAMSFSTFMWGTGAPNIFALL-----AKATHPRVSATAGGIFNGLGNFAGALSP 380
Cdd:cd17327 322 PPGAYFAAYILGGGSYAGFPILlswisSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
71-412 |
1.52e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 71.45 E-value: 1.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 71 ILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFP 150
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 151 QHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRldtKPGTSQTSQDERRAAR 230
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL---PEEKRKPLLSSLLRAY 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 231 RELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRA----AA 306
Cdd:cd17320 195 KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRllrlGL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 307 CFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFAlLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGAL 386
Cdd:cd17320 275 LLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATS-LALEPFPHVAGTASALLGFLQFLIGALAGALVGLL 353
|
330 340
....*....|....*....|....*.
gi 1853294965 387 IAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17320 354 PNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-388 |
5.01e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.91 E-value: 5.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 55 HFQQAMGIDFDTtrLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAE 134
Cdd:cd17503 21 TIMGDLGASLDT--VQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 135 GPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMamltVPVLIFVRIGLRGIRLDt 214
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN----LPIGILALLLAPLLDLR- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 215 kpgtsqtsqderraarreLFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGA 294
Cdd:cd17503 174 ------------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 295 WLSDRVDKR--AAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLG 372
Cdd:cd17503 236 RLLDKFGPRllLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIR 315
|
330
....*....|....*.
gi 1853294965 373 NFAGALSPAVMGALIA 388
Cdd:cd17503 316 QLGGSIGTALLATLLT 331
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
63-411 |
8.36e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 69.20 E-value: 8.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGF-THNYTLMIVLRILLGVAeGPLFPLA 141
Cdd:cd17341 30 GLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALaVSSYWGLLVLGFLLGFA-GANFASG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWL----LGTPVGAAIGFPLSLWLLN---TFGWQSTFFVMAMLTVPVLIFVRIGLRgirldt 214
Cdd:cd17341 109 QPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFdggFVGWRNAFFVPGILLAIAAVLVLLFGD------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 215 KPGTSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSM-PFIAMLAgEVIG 293
Cdd:cd17341 183 DLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALfPLAGALA-RPAG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 294 AWLSDRVDKRA--AACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPN--IFALLAKAtHPRVSATAGGIFN 369
Cdd:cd17341 262 GWLSDRFGGRRrlWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNgsVFRMVPFI-FRRELGAVTGLVG 340
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1853294965 370 GLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMaAVGCVLL 411
Cdd:cd17341 341 AIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVL-AVACTLL 381
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
70-412 |
8.72e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.16 E-value: 8.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNF 149
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 150 PQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRiglrgIRLDTKPGTSQTSQDERRAA 229
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-----LVKDPPPVAAEEAEAGTRAF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 230 RRelFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKgkgIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFI 309
Cdd:cd17489 189 RR--LVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVI-IP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 310 SMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAF 389
Cdd:cd17489 263 GLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL 342
|
330 340
....*....|....*....|...
gi 1853294965 390 ThSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17489 343 F-GYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
61-406 |
1.29e-12 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 68.76 E-value: 1.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 61 GIDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFThNYTLMIVLRILLGVAEGPLFPL 140
Cdd:cd17339 28 DLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLG-GIALLFLGTALAGAGIAVGNVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQHLqARATMLWLLGTPVGAAIGFPLSLWLLNT--FGWQSTffvMAMLTVPVLIFVRIGLRGIRLDTKPGT 218
Cdd:cd17339 107 LPSLIKRDFPRRV-GLMTGLYTTSMNLGAALASGLSVPLAQAlgGGWRGA---LAIWALPALLALLIWLPQLRRRKRAAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 219 SQTSQDERRAARrelfvSPHFWIICIFN--IAFLTYLwgINGWLPGYLIKgKGIHLEHAGWLSSMPFIAMLAGEVIGAWL 296
Cdd:cd17339 183 AAAPLTKISVWR-----SPLAWQVTLFMglQSLLFYT--LMAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLLVPIL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 297 SDRVDKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMsfstfMWGTGAPNIFALL-----AKATHPRVSATAGGIFNGL 371
Cdd:cd17339 255 ATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAV-----LLGLGGGAAFSLAltlisLRSSDPAEAAALSGMAQSV 329
|
330 340 350
....*....|....*....|....*....|....*
gi 1853294965 372 GNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAV 406
Cdd:cd17339 330 GYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
26-204 |
1.36e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.91 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 26 RWAIPLSLLACVLLAFFDKISIAALFSdghfQQAMGIDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMA 105
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALP----SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 106 VWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGW 185
Cdd:COG0477 88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170
....*....|....*....
gi 1853294965 186 QSTFFVMAMLTVPVLIFVR 204
Cdd:COG0477 168 RWIFLINAPLGLLALVLRL 186
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
153-418 |
3.58e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 3.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 153 LQARATMLWLLGTPVGAAIGFPLSLWLL--NTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTKPGTSQtsqderRAAR 230
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSL------KESL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 231 RELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFIS 310
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF-IIG 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 311 MAGAAIGLAA--VMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKA-------THPRVSATAGGIFNGLGNFAGALSPA 381
Cdd:COG2211 301 LLLAALGLLLlfFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGA 380
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1853294965 382 VMGALIAFT----------HSMDSGLIFLAVMAAVGCVLLLPLLRRY 418
Cdd:COG2211 381 LAGLLLALFgyvagaaqspSALTGIRLLFFLLPAVLLLLAALLLLFY 427
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
64-321 |
2.14e-10 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 62.37 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGD-----KIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLF 138
Cdd:PRK09556 61 LSTTELGMIGLGFSITYGVGKTLVGYYADgkntkQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 139 PLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQStffVMAMLTVPVLIFVRIGLRGIR------- 211
Cdd:PRK09556 141 PCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGH---VIGMFIFPSIIALIIGFIGLRygsdspe 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 212 ----------LDTKPGTSQTSQDERRAARRELFV-----SPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAG 276
Cdd:PRK09556 218 elgwgkaeeiFGEPISEEDKETESTDMTKWQIFVeyvlkNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAI 297
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1853294965 277 WLSSMPFIAMLAGEVIGAWLSDRVDKRAAACfismagAAIGLAAV 321
Cdd:PRK09556 298 NTFTLFEIGALVGSLLWGWLSDLANGRRALV------ACIALALI 336
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
71-412 |
3.69e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 61.18 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 71 ILMSAFLLSYGFSSVFLSGLGDKIAplrLLTGMMAVWCVLMVAMgFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFP 150
Cdd:cd17333 39 SQNAGYLIGSLLAGFLMKRLGRRRT---LILGLLLISLALALIF-ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 151 QHLQARatMLWLLGTPVGAAIGFPL--SLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTKPGTSQTSQDERRA 228
Cdd:cd17333 115 ESSATR--LNVLHGFFGLGALIGPLiaTSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 229 ARRELFvsPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcF 308
Cdd:cd17333 193 SRLLRN--PSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLL-V 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 309 ISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKAThPRVSATAGGIFNGLGNFAGALSPAVMGALIA 388
Cdd:cd17333 270 LSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAE 348
|
330 340
....*....|....*....|....
gi 1853294965 389 FTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17333 349 AVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
26-414 |
6.94e-10 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 60.32 E-value: 6.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 26 RWAIPLSLLACVLlaffdkiSIAALFSDGHFQQAMGIDFDTTRLGILM--SAFLLSYGFSSVFLSGLGDKIAPLRLLTGM 103
Cdd:cd17353 2 RWLVLLGAVLMHL-------ILGYQYAWSVFNPPLSSALGWSLASVALafTLTIVFLAISAPFAGRLVDRGGPRKAILIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 104 MAVWCVLMVAMGFTHNYTLM-IVLRILLGVAEGPLFPLAFAIVRHNFPQHLqARATMLWLLGTPVGAAIGFPLSLWLLNT 182
Cdd:cd17353 75 GILFGLGFILSAFAISLPLLfLGYGVLGGIGAGIGYITPVSTAVKWFPDKR-GLATGIVIAGFGLGSLIFSPLIAYLINT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 183 FGWQSTFFVMAMLtvpVLIFVRIGLRGIRL--------DTKPGTSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLW 254
Cdd:cd17353 154 VGVPTTFLILGII---FLIIIVIGAFLIRDppkgwvppGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 255 GINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAM 334
Cdd:cd17353 231 MLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 335 SFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVmGALIAFTHSMDSGLIFLAVMAAVGCVLLLPL 414
Cdd:cd17353 311 ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPII-AAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
69-317 |
1.61e-09 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 59.34 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 69 LGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGF----THNYTLMIVLRILLGVAEGPLFPLAFAI 144
Cdd:PRK11273 65 LGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRT 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 145 VRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFG-WQSTFFVMAMLTVPVLIFVRIGLRGI------------R 211
Cdd:PRK11273 145 MVHWWSQKERGGIVSVWNCAHNVGGGLPPLLFLLGMAWFNdWHAALYMPAFAAILVALFAFAMMRDTpqscglppieeyK 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 212 LDTKPGTSQTSQDERRAarRELFVSPHF-----WIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAM 286
Cdd:PRK11273 225 NDYPDDYNEKHEQELTA--KQIFMQYVLpnkllWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAG 302
|
250 260 270
....*....|....*....|....*....|...
gi 1853294965 287 LAGEVIGAWLSDRVDK--RAAACFISMAGAAIG 317
Cdd:PRK11273 303 IPGTLLCGWMSDKVFRgnRGATGVFFMTLVTIA 335
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
65-412 |
2.76e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.40 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 65 DTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTH-----NYTLMIVLRILLGVAEGPLFP 139
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 140 LAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIgLRGIRLDTKPGTS 219
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLF-IRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 220 QTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDR 299
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 300 VdKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALS 379
Cdd:cd06173 271 R-RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330 340 350
....*....|....*....|....*....|...
gi 1853294965 380 PAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
59-412 |
7.25e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.28 E-value: 7.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 59 AMGIDFDTTRLGILMSAFLLSYgfssvflsgLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLF 138
Cdd:PRK11551 51 QMGWAFSAGILGLLPGALLGGR---------LADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGAL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 139 PLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFV---MAMLTVPVLI--------FVRIGL 207
Cdd:PRK11551 122 PNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVggvGPLLLVPLLMrwlpesraFAQAAG 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 208 RGirlDTKPGTSQTSQDERRAARRELfvsphFWIICIFNIAFLTYLwgINgWLPGYLIkGKGIHLEHAGWLSSMPFIAML 287
Cdd:PRK11551 202 AG---KQRAPVLRALFGEGRATATLL-----LWISYFFTLIVLYFL--LN-WLPSLLV-GQGLSRSQAGLVQIAFNIGGA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 288 AGEVIGAWLSDRVDKRAA--ACFISMAGAAIGLAAVmhldTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHP-RVSATA 364
Cdd:PRK11551 270 LGSLLIGALMDRLRPRRVvlLIYAGILASLAALAAA----PSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPtQVRGTG 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1853294965 365 GGIFNGLGNFAGALSPAVMGALIAFTHSmdSGLIFLA-----VMAAVGCVLLL 412
Cdd:PRK11551 346 VGAAVAVGRLGSMAGPLLAGQLLALGRS--TVGVIGAsipviLVAALAALLLV 396
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
62-417 |
8.05e-09 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 56.96 E-value: 8.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSvFLSG-LGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPL 140
Cdd:cd17343 33 LGLDKSDLGLITSSQSLAYAISK-FIGGvLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQhlQARATMLWLLGTP--VGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPV----LIFVR-----IGLRG 209
Cdd:cd17343 112 CAKILRKWFSP--SQFGTWWSVLSTSmnLAGSLGPILATLLALSYGWRSTLSISGTVAVVMsvvcLLFIKnepsdVGLNN 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 210 IRLDTKPGtSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAG 289
Cdd:cd17343 190 IEEEESKG-KKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 290 EVIGAWLSDRVDKR-----AAACFISMAGA-AIGLAAVMHL-------DTPLTIIAAMSFSTFMWGTGAPNIFALLAKAT 356
Cdd:cd17343 269 SIAAGYLSDWAVAKhgsssRGNPRMPLALVfMAGLTVSLHLfrvhitsDSSELFILLLGFLIGFSLYGPIAIFGVIANES 348
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1853294965 357 HP-RVSATAGGIFNGLGNFAGALSPAVMGaLIAFTHSMDsGLIFLAVMAAVGCVLLLPLLRR 417
Cdd:cd17343 349 APsHLCGTSHAIVALAANVGGVLAGLPFS-YIAKHYDWR-TAFLLLEILCAITVVILFLLRN 408
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
63-388 |
1.40e-08 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 56.19 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVL--MVAMGFTHNYTLMIVLRILLGVAEGPLFPL 140
Cdd:cd17382 45 NWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLnmLIPIAARVHYGCVIFVRILQGLVEGVTYPA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVriglrgirldtkpgtsq 220
Cdd:cd17382 125 CHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW----------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 221 tsqderraarreLFVSPHFWIICIFNIA--FLTYLWGINGwlPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSD 298
Cdd:cd17382 188 ------------MLVSMPVYAIIVANFCrsWTFYLLLISQ--PAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLAD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 299 RVDKRAAA----------CFiSMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGtgapniFALLA-KATH----PRVSAT 363
Cdd:cd17382 254 YLRSRGILsttavrkifnCG-GFGMEATFLLVVAFSHSPTVAISFLVLAVGFSG------FAISGfNVNHldiaPRYASI 326
|
330 340
....*....|....*....|....*
gi 1853294965 364 AGGIFNGLGNFAGALSPAVMGALIA 388
Cdd:cd17382 327 LMGISNGIGTLSGMVCPVIVGALTK 351
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
36-376 |
4.07e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 54.62 E-value: 4.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 36 CVLLAFFDKISIAALfsdGHFQQAMGIDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMG 115
Cdd:TIGR00886 9 GFFLSFLVWFAFSPL---AVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 116 F-THNYTLMIVLRILLGVAeGPLFPLAFAIVRHNFPQHLQARATML------------WLLGTPVGAAIGFPLSLWLLNT 182
Cdd:TIGR00886 86 LaVQSYSVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIQGTALGLaagwgnmgggvaQFVMPPIIGSLIFGGGQPAHLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 183 FGWQSTFFVMAMLTVPVLIFVRIGlrgirLDTKPGTSQTSQDERRAArRELFVSPHFWIICIFNIAFLTYLWGINGWLPG 262
Cdd:TIGR00886 165 WGWAFVIVPAGILLLPALLIFFVG-----ADTPPGKPATGKLSFKEA-LKVFGNRHTWILALLYSVTFGSFLGVSSIFAM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 263 YLIKGKGIHLEHAG-WLSSMPFIAMLAgEVIGAWLSDRVDKR--AAACFISMAGAAIGLAAVMHLDTPLTI-IAAMSFST 338
Cdd:TIGR00886 239 LFKDQFGLSKVQAGaYASLGGFLGSLA-RPAGGAISDRLGGArkLLMNFLGVAMGAFLVVLGLVSDGSLAAfIVLFVALF 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 1853294965 339 FMWGTGAPNIFALLAkATHPRVSATAGGIFNGLGNFAG 376
Cdd:TIGR00886 318 FFAGAGNGSTFALVP-HIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-207 |
5.88e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 5.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGL 207
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
55-414 |
1.05e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 53.33 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 55 HFQQAMGIDfdTTRLGILMSAFLLSYGFSSVFLSGLGDKIAP-LRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVA 133
Cdd:cd17352 28 ELLEEFGES--TSDIAWIGSLLLGVSLFSGPLSSALVNRFGCrPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 134 EGPLFPLAFAIVRHNFpQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFvriglrgirld 213
Cdd:cd17352 106 LGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVC----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 214 tkpgtsqtsqderrAARRELFVSPHFWIICIFNiaFLTYLWGIN--GWLPGYLIKgKGIHLEHAGWLSSMPFIAMLAGEV 291
Cdd:cd17352 174 --------------GLLLRLLKDPTFVLLALGV--SFAMLGFFVpfVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 292 IGAWLSDRVDKRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFST-FMWGTGAPNIFALLAKATHPRVSATAGGIFNG 370
Cdd:cd17352 237 LLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFgFCSGSYSSLTPVILADLVGLEKLSNAYGLVLL 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1853294965 371 LGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPL 414
Cdd:cd17352 317 FQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
64-415 |
3.97e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 51.64 E-value: 3.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSvFLSGL-GDKIAPLRLL-TGMMAVWcVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:cd17488 35 LDKSDIGILGSLFYITYGVSK-FVSGLmSDRSNPRYFMgIGLIATG-IINILFGFSSSLWAFAVLWTLNAFFQGWGWPPC 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGirldtKPgtsqt 221
Cdd:cd17488 113 ARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRD-----RP----- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 222 sqderraarrelfvsPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVD 301
Cdd:cd17488 183 ---------------PYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 302 K--RAAACFISMAGAAIGLAAVMHL-DTPLTIIAAMSFSTFMWGTGAPNIFALLA-KATHPRVSATAGGiFNGLGNFAGA 377
Cdd:cd17488 248 KgnRGPMNLIFALGLLVSVGALWLVpVHSYWLLATCFFTIGFFVFGPQMLIGMAAaECSHKDAAGSATG-FVGLFAYLGA 326
|
330 340 350
....*....|....*....|....*....|....*...
gi 1853294965 378 LSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd17488 327 ALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPLL 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
62-412 |
4.86e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 4.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:cd17477 26 EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGfPLSLWLLNTFGWQsTFFVMAMLTVPVLIFVRIGLRGIRldtkpgtsQT 221
Cdd:cd17477 106 ESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAP--------EI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 222 SQDERRAARRELFVSPHFWIICIFNIAFLTYLWGIngwLPGYLIKgKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVD 301
Cdd:cd17477 176 EEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSL---LPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 302 KR--AAACFISMAGAAIGLAAVMHLDTPLTIIAamsfstFMWGTGAPNIFAL-LAKATH-----PRVSATAG-GIFNGLG 372
Cdd:cd17477 252 RRrvLLGCALLGALAALLLPLVPGLPLALLVLL------FLWGGAAGPLYTLaLALAGDrlpgdELVAANAAlLLLYGLG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1853294965 373 NFAGalsPAVMGALIAFthsMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17477 326 SVIG---PLLAGALMDA---FGPHGLFLFLAAVALLFLLF 359
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
70-211 |
6.82e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.01 E-value: 6.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNF 149
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1853294965 150 PQHLQARATMLWLLGTpVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIR 211
Cdd:COG0738 329 GKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-203 |
1.07e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 13 ASGEGTRTPEKAVRWAIPLSLLACVLLAFFDkisiAALFSDGHFqQAMGIDFDTTRLGILMSAFLLSYGFSSVFLSGLGD 92
Cdd:cd17477 174 EIEEAESISLRRLLRIAPLALLGAFVAGFLE----GAFYSLLPL-YGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 93 KIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMI-VLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAI 171
Cdd:cd17477 249 RFDRRRVLLGCALLGALAALLLPLVPGLPLALlVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVI 328
|
170 180 190
....*....|....*....|....*....|..
gi 1853294965 172 GFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFV 203
Cdd:cd17477 329 GPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
242-417 |
2.05e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 242 ICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGLAAV 321
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL-LIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 322 MHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFtHSMDSGLIFLA 401
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILA 158
|
170
....*....|....*.
gi 1853294965 402 VMAAVGCVLLLPLLRR 417
Cdd:pfam07690 159 ILSLLAAVLLLLPRPP 174
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
72-203 |
2.34e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 49.68 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 72 LMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQ 151
Cdd:TIGR00711 42 VITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPP 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1853294965 152 HLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVmamlTVPVLIFV 203
Cdd:TIGR00711 122 EKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI----NVPIGIIV 169
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
263-416 |
2.40e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.30 E-value: 2.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 263 YLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRA--AACFISMAGAAIGLAAVMHLdtpLTIIAAMSFSTFM 340
Cdd:TIGR00881 20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVflPIGLILCAIVNLFFGFSTSL---WVMAALWALNGIF 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 341 WGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLLR 416
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLR 172
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
71-300 |
2.43e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 49.54 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 71 ILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFP 150
Cdd:PRK12307 57 FLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 151 QHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMltvPVLIFVRIGLRG--------IRLDTKPGTSQTS 222
Cdd:PRK12307 137 KHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLL---PVLLVIYIRARApeskeweeAKLSGKGKHSQSA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 223 QDERRAARRELFVSPHFWI-ICIFNIAFLTY--LWGINGWLPGYLiKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDR 299
Cdd:PRK12307 214 WSVFSLSMKGLFNRAQFPLtLCVFIVLFSIFgaNWPIFGLLPTYL-AGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADR 292
|
.
gi 1853294965 300 V 300
Cdd:PRK12307 293 I 293
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
69-415 |
2.96e-06 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 49.23 E-value: 2.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 69 LGILMSAFLLSYGFsSVFLSG-LGDKIAPLRLLTGMMAVWCVLMVAMG----FTH--NYTLMIVLRILLGVAEGPLFPLA 141
Cdd:cd17342 65 LGVLDTIFLFSYAI-GLFISGwLGDRLNLRLVLAFGMCSSAITVFLFGvlteWLHfyNKYLYCILWVLNGLLQSTGWPCV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNtFGWQSTFFVMAMLTVPVLIFVRIGLrgirLDTKPGTsqt 221
Cdd:cd17342 144 VAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLD-YGYEYAFLVTSSLLFAGAIVVFFGL----LSSPPGV--- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 222 sqderraarrelfvsphfwIICIFNIAFLTYL-WGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRV 300
Cdd:cd17342 216 -------------------IPYSLAYACLKLVnYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRM 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 301 DKRAAACFISMAGAAIGLAAVMHLDTPLTIIAA-MSFSTFMWGTGAPNIFALLAK--ATHP------RVSATAGGIFNGL 371
Cdd:cd17342 277 GSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFvMTITGFFIGGPANLISSAISAdlGRQPqlrgssEALATVTGIIDGT 356
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1853294965 372 GNfAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd17342 357 GS-IGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
122-412 |
3.11e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 49.06 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 122 LMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIG----FPLSLWL----LNTFGWQSTFFVMA 193
Cdd:cd17369 107 LLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAtgvfLLLSALLsdeaFLSWGWRIPFLLSA 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 194 MLtVPVLIFVRIglrgiRLDTKPgTSQTSQDERRAARRELFV-----SPHFWIICIFNIAFLTYLWGINGWLPGYLIKGK 268
Cdd:cd17369 187 VL-VAVGLYIRL-----RLEETP-VFRRAKEAGQVVRAPLVEvlrrhWRALLLAIGLRLAENVLFYLFTTFALSYATQTL 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 269 GIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAACFISMAGAAIGLAAVMHLDT---PLTIIAAMSFSTFMWGTGA 345
Cdd:cd17369 260 GVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTgstWLIVLAAVVVLGVLHGMMY 339
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1853294965 346 PNIFALLAKATHPRVSATAGGIFNGLGN-FAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17369 340 GPQAAFLAELFPTRVRYTGASLGYQLGAiLGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAAL 407
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
168-363 |
4.55e-06 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 48.38 E-value: 4.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 168 GAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTKPGTSQTSqdERRAARRELFVSPHFWIICIFNI 247
Cdd:cd17485 140 GSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQPPASERGA--ALKASLRAFLRRPGTRWLLLFLL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 248 AFLTYLWGINGWLPGYLIKgKGIHLEHAGWLSS-MPFIAMLAGEVIGAWLSDRVDKRAAA-CFISMAGAAIGL--AAVMH 323
Cdd:cd17485 218 LYKLGEQGALAMLPPFLVD-RGFSLSQIGLLSGvGGSLVSIAGSLLGGYLLKRRGRRRLLlLGGLLRLLLLGLytLLALG 296
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1853294965 324 LDT--PLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSAT 363
Cdd:cd17485 297 GSGlnWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGT 338
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
70-207 |
5.51e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 5.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNF 149
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1853294965 150 PQHLQARA----TMLWLLGTPVGAAIGFPLSLWllntFGWQSTFFVMAMLTVPVLIFVRIGL 207
Cdd:cd17391 323 PKEVAGRIfgynQSFQYLGNVAGPLLGSAIAAH----FGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
69-387 |
7.16e-06 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 47.82 E-value: 7.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 69 LGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCV--LMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVR 146
Cdd:TIGR00894 78 QGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVisIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIV 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 147 HNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTF-GWQSTFFVMAMLTVPVLIFVRIGLRG-------IRLDTKPGT 218
Cdd:TIGR00894 158 KWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADdpsihpcISKFEKKYI 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 219 SQTSQDERRAARREL-----FVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIG 293
Cdd:TIGR00894 238 NSSLQGQKGSTRQSLpikaiPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFA 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 294 AWLSD-----RVDKRAAACFI--SMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATH--PRVSATA 364
Cdd:TIGR00894 318 GYLADflkssKTLSLTAARKIfnGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDlaPRFLGFI 397
|
330 340
....*....|....*....|...
gi 1853294965 365 GGIFNGLGNFAGALSPAVMGALI 387
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNIL 420
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
149-384 |
9.93e-06 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 47.21 E-value: 9.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 149 FPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTKPGTSQTSQDERRA 228
Cdd:cd17486 120 LEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYLIMAALMGPGILATLFAPEPPRTDPPANSLSETVVAFFA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 229 ARRELFVSPHFWIICIFniaFLTYLWG---INGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVD-KRA 304
Cdd:cd17486 200 PFKDFFGQPGALLILAF---ILLYKLGdamLGAMATPFLLDLGFTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGlKRS 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 305 A-ACFISMAGAAIGLAAVMHLDTPLTII-AAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAV 382
Cdd:cd17486 277 LwLFGILQALSNLGFIYLAHAGPNLTLLvAAVAVENFGGGLGTTAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAP 356
|
..
gi 1853294965 383 MG 384
Cdd:cd17486 357 SG 358
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
96-412 |
1.01e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 47.41 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 96 PLRLLTGMMAVWCVLMVAMGFThNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHlQARATMLWLLGTPVGAAIGFPL 175
Cdd:cd17314 69 PLMALAGIMVLAGYTYLSYVFN-SFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 176 SLWLLNTFGWQSTFFVMAMLTVPVLIFvrIGLRGIRLDTKPGTSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWG 255
Cdd:cd17314 147 LRILWVFYGLALVYTILGILAAIVLSV--VSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 256 INGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAACFISMAGAAIGLAAVM--HLDTPLTIIAA 333
Cdd:cd17314 225 FIANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLflLKMTPVGLVLT 304
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294965 334 MSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17314 305 GSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
239-417 |
1.58e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 239 FWIICIFNIAFLTYLWGINGWLPgYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGL 318
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-LLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 319 AAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFThSMDSGLI 398
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFL 168
|
170
....*....|....*....
gi 1853294965 399 FLAVMAAVGCVLLLPLLRR 417
Cdd:COG2814 169 VNAVLALLALLLLLRLLPE 187
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
64-412 |
1.62e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.48 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPL---FPL 140
Cdd:cd17393 31 LSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALdvaMNA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 141 AFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVlifvriglrGIRLDTkPGTSQ 220
Cdd:cd17393 111 QGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALV---------AIRALL-PGTGE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 221 TSQDERRAARRELFVSPHFWIICIFNIAFLTYLW--GINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSD 298
Cdd:cd17393 181 AAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAegAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 299 RVDKRAAAcFISMAGAAIGLAAVMHLDTPltIIAAMSFStfMWGTGAPNIFALL---AKATHPRVSATAGGIFNGLGNFA 375
Cdd:cd17393 261 RFGDVAVL-RAGALLAALGLLLALLAPSV--WVALAGFA--LMGLGLSVVVPLAfsaAGALPGLAAGIAVARVATLGYLG 335
|
330 340 350
....*....|....*....|....*....|....*..
gi 1853294965 376 GALSPAVMGALiafTHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17393 336 FLVGPPLIGFL---ADATGLRTAFLVVALLALLVALL 369
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
69-324 |
2.00e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.39 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 69 LGILMSAFLLSYGFSSVFLSGLGDKIAPLR--LLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAeGPLFPLAFAIVR 146
Cdd:cd17471 34 IGIFMTLSALSGIVVSQWLGRLSDRGGDRKplILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLG-AAAFPQLFALAR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 147 HNFPQHLQARATML-----------WLLGTPVGAaigfplslWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTK 215
Cdd:cd17471 113 EYADRSSGRDATLFnsvlraafslaWVIGPPLAF--------LLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 216 PGTSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYlwgingwLPGYLIKGKGIHLEHAGWLSSMP-----FIAMLAGe 290
Cdd:cd17471 185 KATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIA-------MPLYVTNELGGSESWVGLLFGLAaaleiPIMLLAG- 256
|
250 260 270
....*....|....*....|....*....|....*.
gi 1853294965 291 vigaWLSDRVDKRA--AACFISMAGAAIGLAAVMHL 324
Cdd:cd17471 257 ----LLAKRFGKRRllLAGFLAGVLFYLGLALATSL 288
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
55-203 |
3.06e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.64 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 55 HFQQAMGIDFDTTRLGIlmSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAE 134
Cdd:cd17323 24 QIAEDFHVSEEVANLGV--SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFG 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1853294965 135 GPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFV 203
Cdd:cd17323 102 SSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
67-201 |
4.39e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.33 E-value: 4.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 67 TRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVR 146
Cdd:cd17476 33 NQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLG 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 147 HNFPQH-LQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLI 201
Cdd:cd17476 113 RTYPPGpRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAV 168
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
64-211 |
9.37e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 9.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLR--LLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLA 141
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 FAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIR 211
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-418 |
1.68e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 55 HFQQAMGIDFDTTrlGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAE 134
Cdd:cd17329 25 YLHQQLGLSASIV--GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 135 GPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNtFGWQSTFFVMAMLTVPVLIFVRIGLRgirlDT 214
Cdd:cd17329 103 GLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLP----ET 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 215 KPGTSQTSQDERRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGA 294
Cdd:cd17329 178 RPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 295 WLSDRVDKRAAAcFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNF 374
Cdd:cd17329 258 RLVERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1853294965 375 AGALSPAVMGALIAFthsmdSGLIFLAVMAAVGCVLLLPLLRRY 418
Cdd:cd17329 337 GRAIGPLVGGLLLDL-----LGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
154-415 |
2.84e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 154 QARATMLWLLGTP--VGAAIGFPLSLWLLNTFGWQSTFFVMAMLT----VPVLIFVRIGLRGIRLDTKPGTSQTSQDERR 227
Cdd:cd17331 118 GERAAALGRLGLSygIGMVVGSFLGGLLTKKFGEQAAALVAAVGSllsiVLVILLIPSNTKSKREKEAKESASPPSVFNL 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 228 AARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGA-WLSDRVDKRAA- 305
Cdd:cd17331 198 KEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVgPLTKRFGERSLl 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 306 -ACFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGapnIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMG 384
Cdd:cd17331 278 kLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTV---ITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGG 354
|
250 260 270
....*....|....*....|....*....|.
gi 1853294965 385 ALIAFthsmdSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd17331 355 ALLQA-----YGFPSFGLLGAAINGLLTVYL 380
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
66-412 |
3.41e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 42.69 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 66 TTRLGILMSAFLLSYGFsSVFLSG-LGDKIaPLR--LLTGMMAV-WCVLMVAMGFT---HNYTLMIVLRILLGVAEGPLF 138
Cdd:cd17344 61 TELLGALDSAFLFAYAI-GMFFSGhIGERL-PLRyfLSFGMLLSgLFTALFGLGYYwniHSLWYFVVVQILAGLFQSTGW 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 139 PLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNtFGWQSTFFVMAMLTVPVLIFVRIGLrgirLDTKPGT 218
Cdd:cd17344 139 PSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVS-SAWGLSFIVPGIIIAAMGVLVFLFL----VEHPPGV 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 219 SQTSqderraarrelfvsphfwiICIF--NIAFLTYLWgingWLPGYLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWL 296
Cdd:cd17344 214 IEFS-------------------LCLFfaKLVSYTFLY----WLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 297 SDRVDKRAAACFISMAGAAIGL---AAVMHLDTPLTIIAAMSFSTFMWGTgapniFALLAKA------THP------RVS 361
Cdd:cd17344 271 SDYTGGRATTCAAMLILAAPMLfiyNYFGQVSMTTNIVLLIVCGLLVNGP-----YALITTAvsadlgTHKslkgnaRAL 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1853294965 362 ATAGGIFNGLGNFAGALSPAVMGALiaftHSMDSGLIFLAVMAAVGCVLLL 412
Cdd:cd17344 346 ATVTAIIDGTGSIGAALGPLLAGLI----SSRGWNNVFYMLIAADVCAGLL 392
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
70-389 |
3.76e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGpLFPLAFAIVRHNF 149
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 150 PQHLQARA----TMLWLLGTPVGAAIGFplslWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRGIrldtkpgtsqtsqde 225
Cdd:cd17330 116 DEEERAKAfgiiSAAFGLGFILGPALGG----FLSTPYGYALPFLVAAALALLNLVLVLFFLPPL--------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 226 rraaRRELFVSphfwiiCIFNIAFLTYLWGINGWLPGYLIKGKgihlEHAGW-LSSMPFIAMLAGEVIGAWLSDRVDKRA 304
Cdd:cd17330 177 ----RRLLLVY------FLIALAFAGLESVFSLFLKDRFGFSP----SQIGLlLALVGIAGILAQLLLIPRLAKRLGERK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 305 AACfISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMG 384
Cdd:cd17330 243 LLR-LGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAG 321
|
....*
gi 1853294965 385 ALIAF 389
Cdd:cd17330 322 PLYSF 326
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
72-417 |
4.68e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.20 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 72 LMSAFLLSYGFSSVFLSGLGDKIA--PLrLLTGMMAVWCVLMVAMgFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNF 149
Cdd:PRK11652 48 VMAAYLLTYGLSQLFYGPLSDRVGrrPV-ILVGMSIFILGTLVAL-FAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 150 PQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLRgirlDTKPgtsqtsqdeRRAA 229
Cdd:PRK11652 126 EGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP----ETRP---------ADAR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 230 RRELFVSPHFwiiCIFNIAFLTYLWGINGWLPGYLI--KGKGIHLEHAGWLSSMP----FIAMLAGEVIGAWLSDRVDKR 303
Cdd:PRK11652 193 RTRVLASYRT---LLSNRRFNCYLLMLIGTLAGIAVfeACSGVLMGAVLGLSSMTvsilFILPIPAAFFGAWFAGRPNKR 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 304 --------AAACFIsmAGAAIGLAAVMHLDTPLTII--AAMSFstfmwgTGAPNIFALL---AKATHPRVSATAGGIFNG 370
Cdd:PRK11652 270 fstlmwqsVICCLL--AGLLMWIPGWFGVMNVWTLLvpAALFF------FGAGMLFPLAtsgAMEPFPYLAGTAGALLGG 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1853294965 371 LGNFaGALSPAVMGALIAFTHSMDSGLIfLAVMAAVGCVLLLPLLRR 417
Cdd:PRK11652 342 LQNI-GSGLAALLSAMLPQTGQFSLGLL-MTLMGLLILLCWLPLATR 386
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
182-402 |
5.86e-04 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 41.82 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 182 TFGWQSTFFVMAMLTVPVLIFVRIglrgIRLdTKPGTSQTSQDERRAARRELFVSPHFW--IICIFniAFLTYLWGINGW 259
Cdd:cd17394 177 LASVQLPYLGIALVLLLLAVLILL----SKL-PEIEAAEAEALGSKGTLLRLLKNPHLRlgVLAIF--FYVGAEVAIWSF 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 260 LPGYLIKG-KGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVD-KRAAACFISMAGAAIGLAAVMHLDTPLTIIAAMSFS 337
Cdd:cd17394 250 LINYLMEYiAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISpKKLLAVFALLGLLLLLGAIFTGGMVALYALVLVGFF 329
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 338 T-FMWGTgapnIFALlAKATHPRVSATAGGIFNgLGNFAGALSPAVMGALIAFTHSMDSGLIFLAV 402
Cdd:cd17394 330 NsIMFPT----IFSL-ALKGLGKHTKTGSGLLV-MAIVGGAVVPLIQGAVADDAAGLRIAFLVPLL 389
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
63-191 |
9.28e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.22 E-value: 9.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAF 142
Cdd:PRK03893 51 GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSA 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1853294965 143 AIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFV 191
Cdd:PRK03893 131 TYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI 179
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
62-188 |
9.28e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 9.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 62 IDFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGF--THNYTLMIVLRILLGVAEGPLFP 139
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 140 LAFAIV-------RHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQST 188
Cdd:COG2211 339 LPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG 394
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
64-410 |
9.90e-04 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 41.10 E-value: 9.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRIL-LGVAEGP-LFPla 141
Cdd:cd17409 31 LSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIALRSTGSVWALYLGTAIIgAGIAIGNvLLP-- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 142 fAIVRHNFPQHlQARATMLWLLGTPVGAAIGFPLSLWLLNT--FGWQstfFVMAMLTVPVLIFVRIGLRGIRLDTKPGTS 219
Cdd:cd17409 109 -SLLKRDFPAR-VATLTGAYALTMGVGAALGSALVVPLAQVlaFGWQ---LALGAFLVFPLVAALIWLPQLRRHTSPAAD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 220 QTSQDERRAARRelfvSPHFWIICIF---NiAFLTYLwgINGWLPGYLIkGKGIHLEHAGWLSS-MPFIAMLAGEVIGAW 295
Cdd:cd17409 184 TAKPPHGGSVWR----SPLAWQVTLFlglN-SFIYYV--LVGWLPSILT-DAGYSAAQAGSLHGlLQLATAVPGLLLIPV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 296 LSDRVDKRAAACFISMAGAA--IGLAAVMHLDTPLTIIaamsfstFMWGTGAPNIFALL---AKATHPRVSATAGGIFNG 370
Cdd:cd17409 256 LARMKDQRLLAVLVSLLGAVglIGLLLAPSLAILWVIL-------FGFGSGAGFILGLAfigLRTSSAHQAAALSGMAQC 328
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1853294965 371 LGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVL 410
Cdd:cd17409 329 VGYLLAATGPMLVGALHDLTGSWSVPLLLCAALALLMAIF 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
276-417 |
1.21e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 276 GWLSSMPFIAMLAGEVIGAWLSDRVDKRAAAcFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKA 355
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLL-LLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADI 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1853294965 356 THPRVSATAGGIFNGlGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLLRR 417
Cdd:cd17325 113 APPEERGRAMGIFSS-AIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE 173
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
63-183 |
1.23e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 40.69 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 63 DFDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHnytLMIVLRILLGVAEGPLFPLAF 142
Cdd:cd17336 34 GLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLLALPH---FLFVGQFLLGIGSSPLYTLGI 110
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1853294965 143 AIV-----RHNFPQHLqarATMLWLLGtpVGAAIGFPLSLWLLNTF 183
Cdd:cd17336 111 TYIddnvsKKNSPLYI---GILYAMRV--LGPALGFLLGSFLLRIY 151
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
70-208 |
1.57e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.67 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGD----KIAPLRLLTGMmavwCVLMVAMGFTHNYTLMIVLRILLGVAeGPLFPLAFAIV 145
Cdd:PRK09874 57 GLVFSITFLFSAIASPFWGGLADrkgrKIMLLRSALGM----GIVMVLMGLAQNIWQFLILRALLGLL-GGFVPNANALI 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1853294965 146 RHNFPQHLQARATMLWLLGTPVGAAIGfPLSLWLL-NTFGWQSTFFVMAMLTVPVLIFVRIGLR 208
Cdd:PRK09874 132 ATQVPRNKSGWALGTLSTGGVSGALLG-PLAGGLLaDSYGLRPVFFITASVLFLCFLVTLFCIR 194
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
64-415 |
2.31e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 64 FDTTRLGILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFA 143
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 144 IVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNT-FGWQSTFFVMAMLTVPVLIFVRIGLRGIRLDTkpgTSQTS 222
Cdd:cd06180 111 LVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLSAVLLLLSFLLLRRGPSAP---TEASA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 223 QDERRAARRELFVsphfwIICIFNIAFLTYLwGINGWLPGYLIKGKGIHLEhAGWLSSMPFIAMLAGEVIGAWLSDRVDK 302
Cdd:cd06180 188 AESAPGLNRPLWR-----LALAYGLFGFGYI-ITATFLPLIARETGAGSLL-AGLLWSLFGLAAVPSCFLWGALSDRWGT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 303 RAAACfISMAGAAIGLAAVMHLDTPLTIIaamsFSTFMWG---TGAPNIFALLAKATHPRVSATAGGIFN---GLGNFAG 376
Cdd:cd06180 261 RRALA-ANLLVQAVGVLLPLLSPGPAGLV----LSAVLFGgtfMAITALVMALARELAPPAAPRALALMTasfGVGQILG 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 1853294965 377 alsPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLL 415
Cdd:cd06180 336 ---PLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
167-412 |
3.16e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 167 VGAAIGFPLSLWLL--NTFGWQSTFFVMAmltVPVLIFVRIGLRGIRLDTKPGTSQTSQDERRAARRelfvSPHFW---- 240
Cdd:cd17370 135 LGAVLGPLLAALLLylLGGNYRTIFLLAA---IPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKL----PKAFWlyll 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 241 IICIFNIAFLTYlwgingwlpGYLIkgkgIHLEHAGWLSSMPFIAMLAGEVIGA-------WLSDRVDKRAAAcFISMAG 313
Cdd:cd17370 208 AVALFALGNFSF---------AFLI----LRAQELGLSAALIPLLYALFNLVYAlaaypagRLSDRIGRKKLL-ILGYLS 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 314 AAIGLAAVMHLDTPLTIIAAMSFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAfTHSM 393
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD-LISP 352
|
250
....*....|....*....
gi 1853294965 394 DSGLIFLAVMAAVGCVLLL 412
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
70-205 |
3.94e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 70 GILMSAFLLSYGFSSVFLSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNF 149
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 150 PQHlQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRI 205
Cdd:cd17333 318 PYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
111-412 |
4.87e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 38.92 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 111 MVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTfGWQSTFF 190
Cdd:cd17334 87 CIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPP-PKGTKKE 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 191 VMAMLTVP----VLIFVRIgLRGIRLDTKPGTSQTS---------QDERRAARRELFVSPHFWIICIFNIAFLTYLWGIN 257
Cdd:cd17334 166 FGAVFYGEfgfaCLLLALV-LALFPPKPKYPPSAASarqqnsehvILELQKSISELLRNEPFVLLAVAFSIMMGVFAGFS 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 258 GWLpGYLIKGKGIHLEHAGWLSsmpFIAMLAGEVIGAWLSDRVDKRAAACFISMAGAAIGLAA-------VMHLDTPLTI 330
Cdd:cd17334 245 SVL-AQILLPFGVSQTSAGWLG---FFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVctffmllVDRYGLPYVT 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 331 IAAM---SFSTFMWGTGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALIAFThSMDSGLIFLAVMAAVG 407
Cdd:cd17334 321 LAFYllcGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPT-PTESKYLLWFILCTVG 399
|
....*
gi 1853294965 408 CVLLL 412
Cdd:cd17334 400 SCLGA 404
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
263-417 |
5.59e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 5.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 263 YLIKGKGIHLEHAGWLSSMPFIAMLAGEVIGAWLSDRVDKRAAaCFISMAGAAIGLAAVMHLDTPLTIIAAMSFSTFMWG 342
Cdd:cd06174 21 ALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPV-LLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1853294965 343 TGAPNIFALLAKATHPRVSATAGGIFNGLGNFAGALSPAVMGALI-AFTHSMDSGLIFLAVMAAVGCVLLLPLLRR 417
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
65-416 |
6.41e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 38.54 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 65 DTTRLGILMSAFLLSYGFSSvFLSGL-GDKIAPLRLL-TGMMAVWcVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAF 142
Cdd:PRK11663 56 SRSDIGLLATLFYITYGVSK-FVSGIvSDRSNARYFMgIGLIATG-IINILFGFSSSLWAFALLWVLNAFFQGWGWPVCA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 143 AIVRHNFPQHLQARATMLWLLGTPVGAAIgFPLSLWLLN-TFGWQSTFFVMAMLTVPVLIFVriglrGIRLDTKPGT--- 218
Cdd:PRK11663 134 KLLTAWYSRTERGGWWAIWNTAHNVGGAL-IPLVVGAIAlHYGWRYGMMIAGIIAIVVGLFL-----CWRLRDKPQAmgl 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 219 ---SQTSQDE--------------RRAARRELFVSPHFWIICIFNIAFLTYLWGINGWLPGYLIKGKGIHLEHAGWLSSM 281
Cdd:PRK11663 208 psvGEWRHDAlelaqqqegaglsrKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSM 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 282 PFIAMLAGEVIGAWLSDRV--DKRAAACFISMAGAAIGLAA--VMHLDTpLTIIAAMSFST--FMWGtgaPNIFALLAKA 355
Cdd:PRK11663 288 FELGGFIGALVAGWGSDKLfnGNRGPMNLIFAAGILLSVGSlwLMPFAS-YVMQAACFFTIgfFVFG---PQMLIGMAAA 363
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1853294965 356 --THPRVSATAGGiFNGLGNFAGALSPAVMGALIAFTHSMDSGLIFLAVMAAVGCVLLLPLLR 416
Cdd:PRK11663 364 ecSHKEAAGAATG-FVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVISIAAGISALLLLPFLN 425
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
87-208 |
6.41e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.75 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 87 LSGLGDKIAPLRLLTGMMAVWCVLMVAMGFTHNYTLMIVLRILLGVAEGPLFPLAFAIVRHNFPQHLQARATMLWLLGTP 166
Cdd:PRK09874 278 LGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRD 357
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1853294965 167 VGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRIGLR 208
Cdd:PRK09874 358 IGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLR 399
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
69-205 |
7.27e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 7.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1853294965 69 LGILMSAFLL-----SYGFSSVFLSGLGDK-IAPLRLLtgMMAVWCVLMvamGFTHNYTLMIVLRILLGVAEGPLFPLAF 142
Cdd:cd17490 232 LGLLSIIYLLpnalaSLLSGTLFYKKLGERnTIIIGFL--LLGAYCFLI---PFAPNLTLLYLLQALNGFGTGILFPLLM 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1853294965 143 AIVRHNFPQHLQARATMLWLLGTPVGAAIGFPLSLWLLNTFGWQSTFFVMAMLTVPVLIFVRI 205
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| |
