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Conserved domains on  [gi|1852469639|ref|WP_173993692|]
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Xaa-Pro peptidase family protein [Agrobacterium fabrum]

Protein Classification

M24 family metallopeptidase( domain architecture ID 11414248)

M24 family metallopeptidase cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.90.230.10
EC:  3.4.-.-
Gene Ontology:  GO:0008233|GO:0016787|GO:0004177|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24|M24B
PubMed:  7674922|16229471|30536999
SCOP:  3000126

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
25-389 5.67e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


:

Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 229.71  E-value: 5.67e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639  25 ALAREGLSAAGLDALIVTGPENIFYLCGQqTPGYYTFQALILPADGDPVFLIRQLEYfnfiantfisdavvyqdgedpla 104
Cdd:COG0006     1 ARLRALMAEAGLDALLLTDPSNFAYLTGF-RGSPERLAALLVTADGEPVLFVDELEA----------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 105 llvkliesrglasrriaidkrgwflpiavyealqarLGTIGDGAGVIERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAV 184
Cdd:COG0006    57 ------------------------------------ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAAL 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 185 RVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLEMAACHDRYHAALMRSAWIGEPP 264
Cdd:COG0006   101 RPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPS 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 265 TEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGISFapdwGEGAILSlnAGVKTELQ 344
Cdd:COG0006   181 DEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDV----HEGPQIS--PGNDRPLE 254

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1852469639 345 PGMTFHLPPALRIYGRFTVGVSETIVVTETGYRALGSIDRNLLIV 389
Cdd:COG0006   255 PGMVFTIEPGIYIPGIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
25-389 5.67e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 229.71  E-value: 5.67e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639  25 ALAREGLSAAGLDALIVTGPENIFYLCGQqTPGYYTFQALILPADGDPVFLIRQLEYfnfiantfisdavvyqdgedpla 104
Cdd:COG0006     1 ARLRALMAEAGLDALLLTDPSNFAYLTGF-RGSPERLAALLVTADGEPVLFVDELEA----------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 105 llvkliesrglasrriaidkrgwflpiavyealqarLGTIGDGAGVIERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAV 184
Cdd:COG0006    57 ------------------------------------ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAAL 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 185 RVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLEMAACHDRYHAALMRSAWIGEPP 264
Cdd:COG0006   101 RPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPS 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 265 TEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGISFapdwGEGAILSlnAGVKTELQ 344
Cdd:COG0006   181 DEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDV----HEGPQIS--PGNDRPLE 254

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1852469639 345 PGMTFHLPPALRIYGRFTVGVSETIVVTETGYRALGSIDRNLLIV 389
Cdd:COG0006   255 PGMVFTIEPGIYIPGIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 163-376 1.21e-60

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 194.59  E-value: 1.21e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 163 VEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSeYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLE 242
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 243 MAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGIS 322
Cdd:cd01066    80 LGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGHRTGHGIGLE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1852469639 323 FAPDWGegailsLNAGVKTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGY 376
Cdd:cd01066   160 IHEPPV------LKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTEDGP 207
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 164-373 6.82e-41

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 143.54  E-value: 6.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 164 EKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIA-AGSEYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLE 242
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRrGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 243 MAACHD-RYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGI 321
Cdd:pfam00557  81 VGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1852469639 322 SFapdwGEGAILSlNAGVKTELQPGMTFHL-PPALRIYGRFTVGVSETIVVTE 373
Cdd:pfam00557 161 EV----HEGPYIS-RGGDDRVLEPGMVFTIePGIYFIPGWGGVRIEDTVLVTE 208
PRK09795 PRK09795
aminopeptidase; Provisional
 151-388 7.98e-20

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 89.61  E-value: 7.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 151 IERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVGPRTGVPHGTWRR 230
Cdd:PRK09795  121 PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASD 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 231 RAITDGDPAFLEMAACHDRYHAALMRSAWIG--EPPTEAAEMMKACQ---EALQVSLDAIRPGVACEVPHIACQKVIDRA 305
Cdd:PRK09795  201 KIVAAGEFVTLDFGALYQGYCSDMTRTLLVNgeGVSAESHPLFNVYQivlQAQLAAISAIRPGVRCQQVDDAARRVITEA 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 306 GYTENFKKRLGYSVGIS------FAPDWGegailslnagvkTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGYRAL 379
Cdd:PRK09795  281 GYGDYFGHNTGHAIGIEvhedprFSPRDT------------TTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVL 348


                  ....*....
gi 1852469639 380 GSIDRNLLI 388
Cdd:PRK09795  349 YAMPKTVLL 357
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
25-389 5.67e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 229.71  E-value: 5.67e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639  25 ALAREGLSAAGLDALIVTGPENIFYLCGQqTPGYYTFQALILPADGDPVFLIRQLEYfnfiantfisdavvyqdgedpla 104
Cdd:COG0006     1 ARLRALMAEAGLDALLLTDPSNFAYLTGF-RGSPERLAALLVTADGEPVLFVDELEA----------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 105 llvkliesrglasrriaidkrgwflpiavyealqarLGTIGDGAGVIERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAV 184
Cdd:COG0006    57 ------------------------------------ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAAL 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 185 RVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLEMAACHDRYHAALMRSAWIGEPP 264
Cdd:COG0006   101 RPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPS 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 265 TEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGISFapdwGEGAILSlnAGVKTELQ 344
Cdd:COG0006   181 DEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDV----HEGPQIS--PGNDRPLE 254

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1852469639 345 PGMTFHLPPALRIYGRFTVGVSETIVVTETGYRALGSIDRNLLIV 389
Cdd:COG0006   255 PGMVFTIEPGIYIPGIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 163-376 1.21e-60

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 194.59  E-value: 1.21e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 163 VEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSeYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLE 242
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 243 MAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGIS 322
Cdd:cd01066    80 LGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGHRTGHGIGLE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1852469639 323 FAPDWGegailsLNAGVKTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGY 376
Cdd:cd01066   160 IHEPPV------LKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTEDGP 207
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 164-373 6.82e-41

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 143.54  E-value: 6.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 164 EKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIA-AGSEYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLE 242
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRrGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 243 MAACHD-RYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGI 321
Cdd:pfam00557  81 VGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1852469639 322 SFapdwGEGAILSlNAGVKTELQPGMTFHL-PPALRIYGRFTVGVSETIVVTE 373
Cdd:pfam00557 161 EV----HEGPYIS-RGGDDRVLEPGMVFTIePGIYFIPGWGGVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 163-376 5.16e-35

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 128.01  E-value: 5.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 163 VEKLEKAAAYVDEGMRAGLAAVRVGATENDlVSAMLGSAI-AAGSEYLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFL 241
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMTERE-VAAELEYFMrKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 242 EMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVIDRAGYTENFKKRLGYSVGI 321
Cdd:cd01092    80 DFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRTGHGVGL 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1852469639 322 SF--APdwgegailSLNAGVKTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGY 376
Cdd:cd01092   160 EVheAP--------YISPGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLVTEDGC 208
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 22-157 1.32e-21

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 89.28  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639  22 RRQALaREGLSAAGLDALIVTGPENIFYLCGqqTPGYYtFQALILPADGDpVFLIRQLEYFNFIANT-FISDAVVYQDGE 100
Cdd:pfam01321   1 RLEKL-RKLMEEKGLDAALVTSPENLRYLTG--FTGSR-GLLLLVTADGA-LLLVDALEYERAAAESaPDFDVVPYRDYE 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1852469639 101 DplalLVKLIESRGLASRRIAIDKRgwFLPIAVYEALQARLG--TIGDGAGVIERFRAI 157
Cdd:pfam01321  76 A----LADLLKELGAGGKRVGFEAD--ALTVAFYEALKEALPgaELVDVSGLIERLRMV 128
PRK09795 PRK09795
aminopeptidase; Provisional
 151-388 7.98e-20

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 89.61  E-value: 7.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 151 IERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVGPRTGVPHGTWRR 230
Cdd:PRK09795  121 PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASD 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 231 RAITDGDPAFLEMAACHDRYHAALMRSAWIG--EPPTEAAEMMKACQ---EALQVSLDAIRPGVACEVPHIACQKVIDRA 305
Cdd:PRK09795  201 KIVAAGEFVTLDFGALYQGYCSDMTRTLLVNgeGVSAESHPLFNVYQivlQAQLAAISAIRPGVRCQQVDDAARRVITEA 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 306 GYTENFKKRLGYSVGIS------FAPDWGegailslnagvkTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGYRAL 379
Cdd:PRK09795  281 GYGDYFGHNTGHAIGIEvhedprFSPRDT------------TTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVL 348


                  ....*....
gi 1852469639 380 GSIDRNLLI 388
Cdd:PRK09795  349 YAMPKTVLL 357
PRK15173 PRK15173
peptidase; Provisional
 146-387 5.20e-13

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 69.36  E-value: 5.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 146 DGAGVIERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVG----PRT 221
Cdd:PRK15173   84 DSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRFHLISVGadfsPKL 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 222 gVPHGTwrrrAITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKV 301
Cdd:PRK15173  164 -IPSNT----KACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEV 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 302 IDRAGYTENFKKRLGYSVGISFAPDwgEGAILSLNAgvKTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGYRALGS 381
Cdd:PRK15173  239 IKKSGLPNYNRGHLGHGNGVFLGLE--ESPFVSTHA--TESFTSGMVLSLETPYYGYNLGSIMIEDMILINKEGIEFLSK 314


                  ....*.
gi 1852469639 382 IDRNLL 387
Cdd:PRK15173  315 LPRDLV 320
PRK14575 PRK14575
putative peptidase; Provisional
 146-387 1.21e-12

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 68.58  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 146 DGAGVIERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSEYLGMEPLVSVG----PRT 221
Cdd:PRK14575  167 DSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRFHLISVGadfsPKL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 222 gVPHGTwrrrAITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKV 301
Cdd:PRK14575  247 -IPSNT----KACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEV 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 302 IDRAGYTENFKKRLGYSVGISFAPDwgEGAILSLNAgvKTELQPGMTFHLPPALRIYGRFTVGVSETIVVTETGYRALGS 381
Cdd:PRK14575  322 IKKSGLPNYNRGHLGHGNGVFLGLE--ESPFVSTHA--TESFTSGMVLSLETPYYGYNLGSIMIEDMILINKEGIEFLSK 397


                  ....*.
gi 1852469639 382 IDRNLL 387
Cdd:PRK14575  398 LPRDLV 403
PRK14576 PRK14576
putative endopeptidase; Provisional
 17-386 3.70e-12

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 67.35  E-value: 3.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639  17 REEYARRQALAREG---LSAAGLDALIVTGPENIFYLCGQQTPGYYTFQ------ALILPADGDPVFLI-RQLE----YF 82
Cdd:PRK14576    3 KEKIEHLEAVSRKArvvMEREGIDALVVTVCDNFYYLTGFASFFMYTFRhtgaavAIMFRDANIPSQIImNEFEaastHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639  83 NfIANTFISDAVVYQDGEDP---------------------LALLVKLIESRGLASRRIAIDKRgwflpiAVYEALQARL 141
Cdd:PRK14576   83 D-MPNSVLKTFPVWVDVDDPrnphhhykkrdrpigppveavFSLVKNALEDAGVLDKTIAIELQ------AMSNGGKGVL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 142 GTIG------DGAGVIERFRAIKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSEYLGMEPLV 215
Cdd:PRK14576  156 DKVApglklvDSTALFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 216 SVGprtgvphGTWRRRAITDGDPAFLEMAACHD------RYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGV 289
Cdd:PRK14576  236 SVG-------DNFSPKIIADTTPAKVGDLIKFDcgidvaGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGV 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 290 ACEVPHIACQKVIDRAGYTENFKKRLGYSVGISFAPDwgEGAILSLNAgvKTELQPGMTFHLPPALRIYGRFTVGVSETI 369
Cdd:PRK14576  309 KLKAVFDSTMAVIKTSGLPHYNRGHLGHGDGVFLGLE--EVPFVSTQA--TETFCPGMVLSLETPYYGIGVGSIMLEDMI 384

                         410
                  ....*....|....*..
gi 1852469639 370 VVTETGYRALGSIDRNL 386
Cdd:PRK14576  385 LITDSGFEFLSKLDRDL 401
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 225-379 6.18e-10

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 59.04  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 225 HGTWRRRAITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVA-CEVPHiACQKVID 303
Cdd:cd01086    68 HGIPDDRVLKDGDIVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRiGDIGH-AIEKYAE 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 304 RAGYT--ENFKkrlGYSVGISF-----APDWGEGailslNAGVKteLQPGMTFHLPPAL-----RIY------------G 359
Cdd:cd01086   147 KNGYSvvREFG---GHGIGRKFheepqIPNYGRP-----GTGPK--LKPGMVFTIEPMInlgtyEVVtlpdgwtvvtkdG 216

                         170       180
                  ....*....|....*....|
gi 1852469639 360 RFTVGVSETIVVTETGYRAL 379
Cdd:cd01086   217 SLSAQFEHTVLITEDGPEIL 236
PRK05716 PRK05716
methionine aminopeptidase; Validated
 157-379 6.74e-10

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 58.99  E-value: 6.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 157 IKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLvsamlgSAIA--------AGSEYLGMEPL-----VSVGPRtgV 223
Cdd:PRK05716    5 IKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKEL------DRIAeeyirdqgAIPAPLGYHGFpksicTSVNEV--V 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 224 PHGTWRRRAITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVacevpHI-----AC 298
Cdd:PRK05716   77 CHGIPSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGA-----RLgdighAI 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 299 QKVIDRAGYT--ENFkkrLGYSVGISF--APDwgegaILS-LNAGVKTELQPGMTFHLPPALRIyGRFTVGVSE------ 367
Cdd:PRK05716  152 QKYAEAEGFSvvREY---CGHGIGRKFheEPQ-----IPHyGAPGDGPVLKEGMVFTIEPMINA-GKREVKTLKdgwtvv 222

                         250       260
                  ....*....|....*....|....
gi 1852469639 368 ------------TIVVTETGYRAL 379
Cdd:PRK05716  223 tkdgslsaqyehTVAVTEDGPEIL 246
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 157-376 4.11e-09

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 56.77  E-value: 4.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 157 IKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLvsamlgSAIA--------AGSEYLGMEPL-----VSVGPRtgV 223
Cdd:PRK12896   10 IKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKEL------DRIAekrleehgAIPSPEGYYGFpgstcISVNEE--V 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 224 PHGTWRRRAITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGVAcevphiacQKVID 303
Cdd:PRK12896   82 AHGIPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRP--------LNDIG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 304 RAgyTENFKKRLGYSVGISFApdwGEGAILSL-----------NAGVKTELQPGMTFHLPPALRIYGRFTVGVSE----- 367
Cdd:PRK12896  154 RA--IEDFAKKNGYSVVRDLT---GHGVGRSLheepsviltytDPLPNRLLRPGMTLAVEPFLNLGAKDAETLDDgwtvv 228

                         250       260
                  ....*....|....*....|.
gi 1852469639 368 ------------TIVVTETGY 376
Cdd:PRK12896  229 tpdkslsaqfehTVVVTRDGP 249
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
157-379 8.46e-09

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 55.78  E-value: 8.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 157 IKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDL-------------VSAMLGsaiaagseYLGmeplvsvGPRT-- 221
Cdd:COG0024     3 IKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELdriaeefirdhgaIPAFLG--------YYG-------FPKSic 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 222 ---------GVPHgtwrRRAITDGDPAFLEMAACHDRYHAAlmrSAW---IGEPPTEAAEMMKACQEALQVSLDAIRPGV 289
Cdd:COG0024    68 tsvnevvvhGIPS----DRVLKDGDIVNIDVGAILDGYHGD---SARtfvVGEVSPEARRLVEVTEEALYAGIAAAKPGN 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 290 acevpHI-----ACQKVIDRAGYT--ENFkkrLGYSVGISF--APD---WGEgailslnAGVKTELQPGMTFHLPPAL-- 355
Cdd:COG0024   141 -----RLgdighAIQSYAESNGYSvvREF---VGHGIGREMheEPQvpnYGR-------PGRGPRLKPGMVLAIEPMIna 205

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1852469639 356 ---RIY------------GRFTVGVSETIVVTETGYRAL 379
Cdd:COG0024   206 gtpEVKvlddgwtvvtkdGSLSAQFEHTVAVTEDGPEIL 244
PRK12318 PRK12318
methionyl aminopeptidase;
157-384 7.31e-07

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 50.20  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 157 IKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDL--VSAML---GSAIAAGSEYlGMEPLvsvgPRT---------- 221
Cdd:PRK12318   43 IKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELdeLSRELhkeYNAIPAPLNY-GSPPF----PKTictslnevic 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 222 -GVPHGTwrrrAITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGvaceVPHIACQK 300
Cdd:PRK12318  118 hGIPNDI----PLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPG----IPLYEIGE 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 301 VIDRAGYTENFK---KRLGYSVGISFApdwgEGAILS-LNAGVKTELQPGMTFHLPPALriygrfTVGVSE--------- 367
Cdd:PRK12318  190 VIENCADKYGFSvvdQFVGHGVGIKFH----ENPYVPhHRNSSKIPLAPGMIFTIEPMI------NVGKKEgvidpinhw 259

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1852469639 368 ---------------TIVVTETGYRALGSIDR 384
Cdd:PRK12318  260 eartcdnqpsaqwehTILITETGYEILTLLDK 291
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 163-302 1.57e-04

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 42.95  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 163 VEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGSEyLGMEPLVSVGPRTGVPHGTWRRRAITDGDPAFLE 242
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1852469639 243 MAACHDRYHAALMRSAWI-GEPPTEAAEMMKACQEALQVSLDAIRPGVACEVPHIACQKVI 302
Cdd:cd01087    80 AGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVL 140
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 157-289 9.18e-04

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 40.98  E-value: 9.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852469639 157 IKSPLEVEKLEKAAAYVDEGMRAGLAAVRVGATENDLVSAMLGSAIAAGS-----EYLGMEPLVSVGPRTGVPHGTWRRR 231
Cdd:PLN03158  137 IKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGypsplNYHFFPKSCCTSVNEVICHGIPDAR 216

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1852469639 232 AITDGDPAFLEMAACHDRYHAALMRSAWIGEPPTEAAEMMKACQEALQVSLDAIRPGV 289
Cdd:PLN03158  217 KLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGV 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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