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Conserved domains on  [gi|1850116604|ref|WP_172905643|]
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AIDA repeat-containing protein, partial [Escherichia coli]

Protein Classification

autotransporter adhesin family protein( domain architecture ID 1563201)

autotransporter adhesin family protein similar to autotransporter adhesin Ag43 which is a phase-variable, bipartite, outer membrane protein that controls colony form variation and autoaggregation

CATH:  2.160.20.20
SCOP:  4004259

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
auto_Ag43 super family cl40321
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
 1-612 0e+00

Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).


The actual alignment was detected with superfamily member NF033177:

Pssm-ID: 467980 [Multi-domain]  Cd Length: 948  Bit Score: 928.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   1 MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTA 80
Cdd:NF033177    1 MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  81 NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHE 160
Cdd:NF033177   81 NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGTASDTVIRDGGGQSLNGLAVNTTLNGGEQWVHE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 161 GGIATVTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGD 240
Cdd:NF033177  161 GGIATGTVINEKGWQAVKSGALATDTVVNTGAEGGPDAENGDTGQTVYGTAERTTINKNGRQIVAASGTANTTVVYAGGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 241 QTVHGHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAA 320
Cdd:NF033177  241 QTVHGHALDTTLNGGYQYVHNGGTASDTVVNSDGWQVVKEGGLAGNTTVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 321 TVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNA 400
Cdd:NF033177  321 TVTGTNRLGNFSVENGKADNVVLENGGRLDVLEGHSAQNTLVDDGGTLAVSAGGKATTVTMTSGGALIADSGATVEGTNA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 401 SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE 480
Cdd:NF033177  401 SGKFSIDGISGQASGLLLENGGSFTVNAGGQASNTTVGYRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 481 IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLG 560
Cdd:NF033177  481 IRFDNQTTPDAALSRAVAKSNSPVTFHKLTTSNLTGQGGTINMRVTLDGSNVSDQLVINGGQATGKTWLAFTNVGNSNLG 560

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1850116604 561 VATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSE 612
Cdd:NF033177  561 VATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSE 612
 
Name Accession Description Interval E-value
auto_Ag43 NF033177
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
 1-612 0e+00

Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).


Pssm-ID: 467980 [Multi-domain]  Cd Length: 948  Bit Score: 928.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   1 MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTA 80
Cdd:NF033177    1 MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  81 NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHE 160
Cdd:NF033177   81 NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGTASDTVIRDGGGQSLNGLAVNTTLNGGEQWVHE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 161 GGIATVTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGD 240
Cdd:NF033177  161 GGIATGTVINEKGWQAVKSGALATDTVVNTGAEGGPDAENGDTGQTVYGTAERTTINKNGRQIVAASGTANTTVVYAGGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 241 QTVHGHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAA 320
Cdd:NF033177  241 QTVHGHALDTTLNGGYQYVHNGGTASDTVVNSDGWQVVKEGGLAGNTTVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 321 TVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNA 400
Cdd:NF033177  321 TVTGTNRLGNFSVENGKADNVVLENGGRLDVLEGHSAQNTLVDDGGTLAVSAGGKATTVTMTSGGALIADSGATVEGTNA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 401 SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE 480
Cdd:NF033177  401 SGKFSIDGISGQASGLLLENGGSFTVNAGGQASNTTVGYRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 481 IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLG 560
Cdd:NF033177  481 IRFDNQTTPDAALSRAVAKSNSPVTFHKLTTSNLTGQGGTINMRVTLDGSNVSDQLVINGGQATGKTWLAFTNVGNSNLG 560

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1850116604 561 VATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSE 612
Cdd:NF033177  561 VATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSE 612
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
5-480 2.34e-37

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 149.04  E-value: 2.34e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604    5 LNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVvqAGETVNGGTLTNHDNQIVF--GTANG 82
Cdd:NF033176     1 MNKAYSIVWNHSRQAWVVASELARGHGFVLAKNTLLVLAVASTIGNAFAQNI--SSGVVSGGVVSSGETQVVYsnGQTSN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   83 MTISTGLEYGPDNEANT--------GGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISaGGGQSLQ--GQAVNTTL- 151
Cdd:NF033176    79 ATVNSGGIQNVNNGGKTtsttvnssGAQNVGNSGTAISTIVNSGGVQRVSSGGVTSATSLS-GGAQNIYnlGHASNTVIf 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  152 NGGEQWVHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAeggpdAENGDTGqnvyGDAVRTTINKNGRQIVAAEGTAN 231
Cdd:NF033176   158 NGGNQTIFSGGISDDTNISSGGQQRVSSGGVASNTTINSSG-----TQNILSG----GSTVSTHISSGGNQYISAGGNAS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  232 TTVVYAGGDQTVH--GHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLK 309
Cdd:NF033176   229 ATVVSSGGFQRVSsgGTATGTVLSGGTQNVSSGGSAISTSVYSSGVQTVYAGATVTDTTVNSGGKQNISSGGIVSGTIVN 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  310 QGGALVTSTAATVLGSNRLGNFTVEN-GKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALI 388
Cdd:NF033176   309 SSGTQNIYSGGSALSANIKGSQIVNSdGTAINTLVNDGGYQHIRNGGVASGTIINQSGRVNISSGGYAESTIINSGGTQS 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  389 ADSGATVEGT--NASGKFSIDGiSGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGrTQLSKGASMVLN 466
Cdd:NF033176   389 VLSGGYASGTliNNSGRENVSN-GGSAYNTIINAGGNQYIYSNGEASGTTVNTSGFQRVNSGGTATG-TKLSGGNQNVSS 466

                          490
                   ....*....|....
gi 1850116604  467 GDVVSTGDIVNAGE 480
Cdd:NF033176   467 GGKAIAAEVYSGGK 480
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
98-611 2.31e-35

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 142.88  E-value: 2.31e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   98 NTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQ--GQAVNTTLNGGEQWVHEGGIATVTVINEKGWQ 175
Cdd:NF033176   402 NSGRENVSNGGSAYNTIINAGGNQYIYSNGEASGTTVNTSGFQRVNsgGTATGTKLSGGNQNVSSGGKAIAAEVYSGGKQ 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  176 AVKSGAMATDT------VVNTGAEGGPDAENGDTGQ-NVY-GDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTV--HG 245
Cdd:NF033176   482 TVYAGGEASGTqifdggVVNVSGGSVSGASVNLNGRlNVFaGNVTGTILNQEGRQYIYSGASATSTVANNEGREYVlsGG 561

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  246 HALDTTLN-GGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLG 324
Cdd:NF033176   562 VADGTVLNsGGLQAVSSGGSASATVINEGGSQFVYEGGNVTGTVIKNGGAIRVDSGASALNIALSSGGNLFTSTGATVTG 641

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  325 SNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEG------- 397
Cdd:NF033176   642 TNHYGSFSVSQNHASNVVLENGGLLAVTSGSTATDTTVNSAGRLRIDEGGALDGTTTINADGIVAGAKIKNDGdfilnla 721

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  398 ----------------TNASGKFSIDGISGQASGLLLENGGsFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGrtQLSKGA 461
Cdd:NF033176   722 gdydfntelsgngalvKDNSGVMSYEGTLTQARGVNVKNGG-IILGSAVVNADMAVSQNAYINISDQATING--SVNNKG 798

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  462 SMVLNGDVVStGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPV-------TFHKLTTTNLTGQ-GGTINMRVRLDGSNTS 533
Cdd:NF033176   799 SVVINNSIIN-GNITNDADLSFGTAKLLSATVNGSLVNNKNIIlnptkesAGNTLTVSNYTGTpGSVISLGGVLEGDNSL 877

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  534 DQLVINGGQATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNGAtteEGAFALSRPLQAGAFNYTLNRDS-----DEDWY 608
Cdd:NF033176   878 TDRLVVKGNTSGQSDIVYVNEGGSG---GQTIEGINIISVEGNS---DAEFSLKNRVVAGAYDYTLQKGNvsgtdKKGWY 951


                   ...
gi 1850116604  609 LRS 611
Cdd:NF033176   952 LTS 954
PL2_Passenger_AT cd01344
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of ...
 422-612 1.94e-27

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43, AIDA-1 and IcsA, as well as, the less characterized ShdA, MisL, and BapA autotransporters.


Pssm-ID: 238654 [Multi-domain]  Cd Length: 188  Bit Score: 109.31  E-value: 1.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 422 GSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNgdvvSTGDIVNAGEIHFDNQTTQDAvlSRAVAKGD 501
Cdd:cd01344     1 GTITGNGGWKLGGDLTLGGGALTLTTSLTLTGTLLTGGAGTLTLD----STSTWNITGTSTLNVGNLTNA--GTIDLGNG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 502 SPVTFHKLTTTNLTGQGGTINMRVRLDGSN-TSDQLVINGGqATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNgaTTE 580
Cdd:cd01344    75 SPAGGTLTITGNYTGNGGTLRLNTVLGDDDsPTDRLVIDGD-ASGTTRVAVNNAGGSG---ATTGNGIEVVEVGG--TSS 148

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1850116604 581 EGAFALSRPLQAGAFNYTLNRDS----DEDWYLRSE 612
Cdd:cd01344   149 NGAFSLAGRVVAGAYEYRLYRGGvsgnDGNWYLRSE 184
PRK09945 PRK09945
hypothetical protein; Provisional
 250-456 5.99e-17

hypothetical protein; Provisional


Pssm-ID: 137602 [Multi-domain]  Cd Length: 418  Bit Score: 83.61  E-value: 5.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 250 TTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLG 329
Cdd:PRK09945   26 TQLTEGELIVEAGGRAENTVVTGAGWLKVATGGIAKCTQYGNNGTLSVSDGAIATDIVQSEGGAISLSTLATVNGRHPEG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 330 NFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSagGKATDVTMTSGGALIADSGATVEG--TNASGKFSid 407
Cdd:PRK09945  106 EFSVDQGYACGLLLENGGNLRVLEGHRAEKIILDQEGGLLVN--GTTSAVVVDEGGELLVYPGGEASNceINQGGVFM-- 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1850116604 408 gISGQASGLLLENGGsfTVNAGGQAGNTTVGHRGTLTLAAGG---SLSGRTQ 456
Cdd:PRK09945  182 -LAGKASDTLLAGGT--MNNLGGEDSDTIVENGSIYRLGTDGlqlYSSGKTQ 230
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 106-612 4.67e-16

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 81.92  E-value: 4.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 106 NGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAMATD 185
Cdd:COG3468    23 LGGTGGGNAGLGIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGGNSGTGGTG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 186 TVVNTGAEGGPDAENGDTGQN-VYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNGGT 264
Cdd:COG3468   103 GGGGGGGSGNGGGGGGGGGGGgTGGGGGGGTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGSGGGGGAGGGGGGGA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 265 ASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLE 344
Cdd:COG3468   183 GGSGGAGSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTG 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 345 SGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGGSF 424
Cdd:COG3468   263 GGGGGTGTGSGGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTT 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 425 TVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQlskGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPV 504
Cdd:COG3468   343 LNGAGSAGGGTGAALAGTGGSGSGGGGGGGSG---GGGGAGGGGANTGSDGVGTGLTTGGTGNNGGGGVGGGGGGGLTLT 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 505 TFHKLTTTNLTGQGGTINMRVRL-DGSNTSDQLVINGGqATGKTWLAFTNVGNSnlgVATTGQGIRVVDAqNGATTeeGA 583
Cdd:COG3468   420 GGTLTVNGNYTGNNGTLVLNTVLgDDNSPTDRLVVNGN-TSGTTGVRVNNAGGL---GAQTVNGIEVVEV-NGASD--GA 492

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1850116604 584 FALSRPLQAGAFNYTLNR----DSDEDWYLRSE 612
Cdd:COG3468   493 FTLGGRVVAGAYEYTLYQggsgGDDGNWYLRST 525
AC_1 pfam18883
Autochaperone Domain Type 1; This entry represents the autochaperone domain of type 1 (AC-1) ...
 501-599 2.10e-13

Autochaperone Domain Type 1; This entry represents the autochaperone domain of type 1 (AC-1) in the Type Va Secretion System (T5aSS). Autotransporters (ATs) belong to a family of modular proteins secreted by the Type V, subtype a, secretion system (T5aSS) and considered as an important source of virulence factors in lipopolysaccharidic diderm bacteria (archetypical Gram-negative bacteria). The AC of type 1 with beta-fold appears as a prevalent and conserved structural element exclusively associated to beta-helical AT passenger.


Pssm-ID: 465898 [Multi-domain]  Cd Length: 114  Bit Score: 66.86  E-value: 2.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 501 DSPVTFHKLTTTN-LTGQGGTINMRVRLDGSNT-SDQLVINGGQATGKTWLAFTNVGNSnlGVATTGQGIRVVDAqnGAT 578
Cdd:pfam18883  18 PSGASYKTLTVDGdYTGNDGTLALNTYLGGDGSpSDKLVIDGGTASGTTNLRINNTGGP--GALTTNDGILVVDV--GGT 93

                          90       100
                  ....*....|....*....|.
gi 1850116604 579 TEEGAFALSRPLQAGAFNYTL 599
Cdd:pfam18883  94 TSDGAFRLAGRAVAGPYEYLL 114
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 505-611 5.25e-05

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 45.84  E-value: 5.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 505 TFHKLTTTNLTGQGGTINMRVRLDGSN-TSDQLVINGgQATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNGAtteEGA 583
Cdd:TIGR01414   4 AFNTLTVNGLYTGNGGFVMNTDLGGDNsQTDRLVVNG-NASGTTGVVVNNIGGEG---AQTGDGITLVTVNGGS---DAA 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1850116604 584 FALSRP-LQAGAFNYTLNRD---SDEDWYLRS 611
Cdd:TIGR01414  77 FTLANGkVDAGAYTYTLYKNgteDNNNWYLTS 108
auto_BafA_Cterm NF040482
BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and ...
 48-189 1.64e-04

BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and Bartonella quintana, and possibly all Bartonella BafA, are mitogenic autotransporter virulence factors that help induce vasoproliferative lesions during infection. This HMM represents the more conserved C-terminal portion only, as the passenger region is more highly variable in length and sequence.


Pssm-ID: 468508 [Multi-domain]  Cd Length: 617  Bit Score: 44.63  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  48 VPALAADTVVQAGetvnGGTLtnhDNQIVFGtaNGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGG 127
Cdd:NF040482    5 KGSSAYDTVIYGQ----GETL---GQQNVYD--GGIAWNTKVMQGGVQNVAKKSQSAKNGGFAFNTEVFGGGKQRVLAGG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1850116604 128 SvsdtvisagggqslqgqAVNTTLNGGE-QWVHEGGIATVTVINEKGWQAVKSGA-MATDTVVN 189
Cdd:NF040482   76 K-----------------AIGVTLNETAvQEIYAGGFVKNLTINDEAKSWVYAGAtLEGKTLVN 122
 
Name Accession Description Interval E-value
auto_Ag43 NF033177
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
 1-612 0e+00

Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).


Pssm-ID: 467980 [Multi-domain]  Cd Length: 948  Bit Score: 928.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   1 MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTA 80
Cdd:NF033177    1 MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  81 NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHE 160
Cdd:NF033177   81 NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGTASDTVIRDGGGQSLNGLAVNTTLNGGEQWVHE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 161 GGIATVTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGD 240
Cdd:NF033177  161 GGIATGTVINEKGWQAVKSGALATDTVVNTGAEGGPDAENGDTGQTVYGTAERTTINKNGRQIVAASGTANTTVVYAGGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 241 QTVHGHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAA 320
Cdd:NF033177  241 QTVHGHALDTTLNGGYQYVHNGGTASDTVVNSDGWQVVKEGGLAGNTTVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 321 TVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNA 400
Cdd:NF033177  321 TVTGTNRLGNFSVENGKADNVVLENGGRLDVLEGHSAQNTLVDDGGTLAVSAGGKATTVTMTSGGALIADSGATVEGTNA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 401 SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE 480
Cdd:NF033177  401 SGKFSIDGISGQASGLLLENGGSFTVNAGGQASNTTVGYRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 481 IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLG 560
Cdd:NF033177  481 IRFDNQTTPDAALSRAVAKSNSPVTFHKLTTSNLTGQGGTINMRVTLDGSNVSDQLVINGGQATGKTWLAFTNVGNSNLG 560

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1850116604 561 VATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSE 612
Cdd:NF033177  561 VATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSE 612
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
5-480 2.34e-37

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 149.04  E-value: 2.34e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604    5 LNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVvqAGETVNGGTLTNHDNQIVF--GTANG 82
Cdd:NF033176     1 MNKAYSIVWNHSRQAWVVASELARGHGFVLAKNTLLVLAVASTIGNAFAQNI--SSGVVSGGVVSSGETQVVYsnGQTSN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   83 MTISTGLEYGPDNEANT--------GGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISaGGGQSLQ--GQAVNTTL- 151
Cdd:NF033176    79 ATVNSGGIQNVNNGGKTtsttvnssGAQNVGNSGTAISTIVNSGGVQRVSSGGVTSATSLS-GGAQNIYnlGHASNTVIf 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  152 NGGEQWVHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAeggpdAENGDTGqnvyGDAVRTTINKNGRQIVAAEGTAN 231
Cdd:NF033176   158 NGGNQTIFSGGISDDTNISSGGQQRVSSGGVASNTTINSSG-----TQNILSG----GSTVSTHISSGGNQYISAGGNAS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  232 TTVVYAGGDQTVH--GHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLK 309
Cdd:NF033176   229 ATVVSSGGFQRVSsgGTATGTVLSGGTQNVSSGGSAISTSVYSSGVQTVYAGATVTDTTVNSGGKQNISSGGIVSGTIVN 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  310 QGGALVTSTAATVLGSNRLGNFTVEN-GKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALI 388
Cdd:NF033176   309 SSGTQNIYSGGSALSANIKGSQIVNSdGTAINTLVNDGGYQHIRNGGVASGTIINQSGRVNISSGGYAESTIINSGGTQS 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  389 ADSGATVEGT--NASGKFSIDGiSGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGrTQLSKGASMVLN 466
Cdd:NF033176   389 VLSGGYASGTliNNSGRENVSN-GGSAYNTIINAGGNQYIYSNGEASGTTVNTSGFQRVNSGGTATG-TKLSGGNQNVSS 466

                          490
                   ....*....|....
gi 1850116604  467 GDVVSTGDIVNAGE 480
Cdd:NF033176   467 GGKAIAAEVYSGGK 480
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
98-611 2.31e-35

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 142.88  E-value: 2.31e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   98 NTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQ--GQAVNTTLNGGEQWVHEGGIATVTVINEKGWQ 175
Cdd:NF033176   402 NSGRENVSNGGSAYNTIINAGGNQYIYSNGEASGTTVNTSGFQRVNsgGTATGTKLSGGNQNVSSGGKAIAAEVYSGGKQ 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  176 AVKSGAMATDT------VVNTGAEGGPDAENGDTGQ-NVY-GDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTV--HG 245
Cdd:NF033176   482 TVYAGGEASGTqifdggVVNVSGGSVSGASVNLNGRlNVFaGNVTGTILNQEGRQYIYSGASATSTVANNEGREYVlsGG 561

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  246 HALDTTLN-GGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLG 324
Cdd:NF033176   562 VADGTVLNsGGLQAVSSGGSASATVINEGGSQFVYEGGNVTGTVIKNGGAIRVDSGASALNIALSSGGNLFTSTGATVTG 641

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  325 SNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEG------- 397
Cdd:NF033176   642 TNHYGSFSVSQNHASNVVLENGGLLAVTSGSTATDTTVNSAGRLRIDEGGALDGTTTINADGIVAGAKIKNDGdfilnla 721

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  398 ----------------TNASGKFSIDGISGQASGLLLENGGsFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGrtQLSKGA 461
Cdd:NF033176   722 gdydfntelsgngalvKDNSGVMSYEGTLTQARGVNVKNGG-IILGSAVVNADMAVSQNAYINISDQATING--SVNNKG 798

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  462 SMVLNGDVVStGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPV-------TFHKLTTTNLTGQ-GGTINMRVRLDGSNTS 533
Cdd:NF033176   799 SVVINNSIIN-GNITNDADLSFGTAKLLSATVNGSLVNNKNIIlnptkesAGNTLTVSNYTGTpGSVISLGGVLEGDNSL 877

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  534 DQLVINGGQATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNGAtteEGAFALSRPLQAGAFNYTLNRDS-----DEDWY 608
Cdd:NF033176   878 TDRLVVKGNTSGQSDIVYVNEGGSG---GQTIEGINIISVEGNS---DAEFSLKNRVVAGAYDYTLQKGNvsgtdKKGWY 951


                   ...
gi 1850116604  609 LRS 611
Cdd:NF033176   952 LTS 954
PL2_Passenger_AT cd01344
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of ...
 422-612 1.94e-27

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43, AIDA-1 and IcsA, as well as, the less characterized ShdA, MisL, and BapA autotransporters.


Pssm-ID: 238654 [Multi-domain]  Cd Length: 188  Bit Score: 109.31  E-value: 1.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 422 GSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNgdvvSTGDIVNAGEIHFDNQTTQDAvlSRAVAKGD 501
Cdd:cd01344     1 GTITGNGGWKLGGDLTLGGGALTLTTSLTLTGTLLTGGAGTLTLD----STSTWNITGTSTLNVGNLTNA--GTIDLGNG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 502 SPVTFHKLTTTNLTGQGGTINMRVRLDGSN-TSDQLVINGGqATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNgaTTE 580
Cdd:cd01344    75 SPAGGTLTITGNYTGNGGTLRLNTVLGDDDsPTDRLVIDGD-ASGTTRVAVNNAGGSG---ATTGNGIEVVEVGG--TSS 148

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1850116604 581 EGAFALSRPLQAGAFNYTLNRDS----DEDWYLRSE 612
Cdd:cd01344   149 NGAFSLAGRVVAGAYEYRLYRGGvsgnDGNWYLRSE 184
PRK09945 PRK09945
hypothetical protein; Provisional
 250-456 5.99e-17

hypothetical protein; Provisional


Pssm-ID: 137602 [Multi-domain]  Cd Length: 418  Bit Score: 83.61  E-value: 5.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 250 TTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLG 329
Cdd:PRK09945   26 TQLTEGELIVEAGGRAENTVVTGAGWLKVATGGIAKCTQYGNNGTLSVSDGAIATDIVQSEGGAISLSTLATVNGRHPEG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 330 NFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSagGKATDVTMTSGGALIADSGATVEG--TNASGKFSid 407
Cdd:PRK09945  106 EFSVDQGYACGLLLENGGNLRVLEGHRAEKIILDQEGGLLVN--GTTSAVVVDEGGELLVYPGGEASNceINQGGVFM-- 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1850116604 408 gISGQASGLLLENGGsfTVNAGGQAGNTTVGHRGTLTLAAGG---SLSGRTQ 456
Cdd:PRK09945  182 -LAGKASDTLLAGGT--MNNLGGEDSDTIVENGSIYRLGTDGlqlYSSGKTQ 230
PL_Passenger_AT cd00253
Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V ...
 432-612 1.34e-16

Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain of autotransporters forms a pore in the outer membrane through which the N-terminal passenger domain is transported. Following transport, the passenger domain is generally cleaved by an outer membrane protease with the passenger domain either remaining in contact with the surface via a noncovalent interaction with the beta domain or cleaved to release a soluble protein. These proteins are highly diverse and perform a variety of functions that promote virulence, including catalyzing proteolysis, serving as an adhesin, mediating actin-promoted motility, or serving as a cytotoxin. Proteins in this family share similarity in the C-terminal region of the passenger domain as seen in the pertactin structure P.69, a Bordetella pertussis agglutinogen responsible for human pertussis. The P.69 protein consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is one of the largest beta-helix known to date.


Pssm-ID: 238156 [Multi-domain]  Cd Length: 186  Bit Score: 78.18  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 432 AGNTTVGHRGTLTLAAGGSLSGRTQLSKGA-SMVLNGDVVSTGDIVNAGEIHFDNqttqdavlSRAVAKGDSPVTFHKLT 510
Cdd:cd00253    12 GGDLTLGGGGALTLTGNSVWLGTLQAGGGTvSLNSNSLWTLTGDSTVNGNLTNSG--------GTVDFGSASGAFNTLTV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 511 TTNLTGQGGTINMRVRLDG-SNTSDQLVINGgQATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNGattEEGAFALSRP 589
Cdd:cd00253    84 NGNYLGGNGTFVLNTDLGGdNSPTDKLVVTG-NASGTTNVAVVNAGGEG---ASTGDGIELVEVNGG---SDAAFSLAGR 156

                         170       180
                  ....*....|....*....|....*.
gi 1850116604 590 LQAGAFNYTLNRDS---DEDWYLRSE 612
Cdd:cd00253   157 VDAGAYEYTLYKGGvgnNGNWYLRST 182
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 106-612 4.67e-16

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 81.92  E-value: 4.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 106 NGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAMATD 185
Cdd:COG3468    23 LGGTGGGNAGLGIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGGNSGTGGTG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 186 TVVNTGAEGGPDAENGDTGQN-VYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNGGT 264
Cdd:COG3468   103 GGGGGGGSGNGGGGGGGGGGGgTGGGGGGGTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGSGGGGGAGGGGGGGA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 265 ASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLE 344
Cdd:COG3468   183 GGSGGAGSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTG 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 345 SGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGGSF 424
Cdd:COG3468   263 GGGGGTGTGSGGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTT 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 425 TVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQlskGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPV 504
Cdd:COG3468   343 LNGAGSAGGGTGAALAGTGGSGSGGGGGGGSG---GGGGAGGGGANTGSDGVGTGLTTGGTGNNGGGGVGGGGGGGLTLT 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 505 TFHKLTTTNLTGQGGTINMRVRL-DGSNTSDQLVINGGqATGKTWLAFTNVGNSnlgVATTGQGIRVVDAqNGATTeeGA 583
Cdd:COG3468   420 GGTLTVNGNYTGNNGTLVLNTVLgDDNSPTDRLVVNGN-TSGTTGVRVNNAGGL---GAQTVNGIEVVEV-NGASD--GA 492

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1850116604 584 FALSRPLQAGAFNYTLNR----DSDEDWYLRSE 612
Cdd:COG3468   493 FTLGGRVVAGAYEYTLYQggsgGDDGNWYLRST 525
AC_1 pfam18883
Autochaperone Domain Type 1; This entry represents the autochaperone domain of type 1 (AC-1) ...
 501-599 2.10e-13

Autochaperone Domain Type 1; This entry represents the autochaperone domain of type 1 (AC-1) in the Type Va Secretion System (T5aSS). Autotransporters (ATs) belong to a family of modular proteins secreted by the Type V, subtype a, secretion system (T5aSS) and considered as an important source of virulence factors in lipopolysaccharidic diderm bacteria (archetypical Gram-negative bacteria). The AC of type 1 with beta-fold appears as a prevalent and conserved structural element exclusively associated to beta-helical AT passenger.


Pssm-ID: 465898 [Multi-domain]  Cd Length: 114  Bit Score: 66.86  E-value: 2.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 501 DSPVTFHKLTTTN-LTGQGGTINMRVRLDGSNT-SDQLVINGGQATGKTWLAFTNVGNSnlGVATTGQGIRVVDAqnGAT 578
Cdd:pfam18883  18 PSGASYKTLTVDGdYTGNDGTLALNTYLGGDGSpSDKLVIDGGTASGTTNLRINNTGGP--GALTTNDGILVVDV--GGT 93

                          90       100
                  ....*....|....*....|.
gi 1850116604 579 TEEGAFALSRPLQAGAFNYTL 599
Cdd:pfam18883  94 TSDGAFRLAGRAVAGPYEYLL 114
ESPR pfam13018
Extended Signal Peptide of Type V secretion system; This conserved domain is called ESPR for ...
 6-53 3.51e-11

Extended Signal Peptide of Type V secretion system; This conserved domain is called ESPR for Extended Signal Peptide Region. It is present at the N-terminus of the signal peptides of proteins belonging to the Type V secretion systems, including the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (TAAs). So far, the ESPR is present only in Gram-negative bacterial proteins originating from the classes Beta- and Gamma-proteobacteria. ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation. Deletion of ESPR causes mis-folding of the TAAs passenger domain in the periplasm, substantially impairing its translocation across the outer membrane.


Pssm-ID: 463773 [Multi-domain]  Cd Length: 50  Bit Score: 58.32  E-value: 3.51e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1850116604   6 NTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAA 53
Cdd:pfam13018   2 NKIYRVIWNRARGAWVVVSELAKSKGKSSSSSSGSAAALAALLLLLLA 49
AIDA pfam16168
Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on ...
 329-385 8.60e-11

Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on bacterial autotransporter proteins. As the repeat is short and occurs multiple times, it is likely to be the region of the transporter that acts as the stalk between the beta-barrel inserted into the membrane and the N-terminal head domain.


Pssm-ID: 406554 [Multi-domain]  Cd Length: 57  Bit Score: 57.34  E-value: 8.60e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1850116604 329 GNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGG 385
Cdd:pfam16168   1 GAFSISGGVADNVLLENGGSLTVVAGTSATDTTVDKGGTLDVQSGGTATGTVVNNGG 57
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 16-579 6.32e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 55.93  E-value: 6.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   16 ITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTANGMTISTGLEYGPDN 95
Cdd:COG3210    179 TTGGSLNVVAANPTGVTGVGGALINATAGVLANAGGGTAGGVASANSTLTGGVVAAGTGAGVISTGGTDISSLSVAAGAG 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   96 EANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQ 175
Cdd:COG3210    259 TGGAGGTGNAGNTTIGTTVTGTNATGSNTAGASSGDTTTNGTSSVTGAGGTGVLGGGTAAGITTTNTVGGNGDGNNTTAN 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  176 AVKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGG 255
Cdd:COG3210    339 SGAGLVSGGTGGNNGTTGTGAGSGLTGTGNGGGLTTAGAGTVASTVGTATASTGNASSTTVLGSGSLATGNTGTTIAGNG 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  256 YQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQ--KGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTV 333
Cdd:COG3210    419 GSANAGGFTTTGGVLGITGNGTVTGGTIGGLTGSGTtnGAGLSGNTDVSGTGTVTNSAGNTTSATTLAGGGIGTVTTNAT 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  334 ENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQA 413
Cdd:COG3210    499 ISNNAGGDANGIATGLTGITAGGGGGGNATSGGTGGDGTTLSGSGLTTTVSGGASGTTAASGSNTANTLGVLAATGGTSN 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  414 SGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVL 493
Cdd:COG3210    579 ATTAGNSTSATGGTGTNSGGTVLSIGTGSAGATGTITLGAGTSGAGANATGGGAGLTGSAVGAALSGTGSGTTGTASANG 658

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  494 SRAVAKGDSPVTfhkLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLGVATTGQGIRVVDA 573
Cdd:COG3210    659 SNTTGVNTAGGT---GGGTTGTVTSGATGGTTGTTLNAATGGTLNNAGNTLTISTGSITVTGQIGALANANGDTVTFGNL 735


                   ....*.
gi 1850116604  574 QNGATT 579
Cdd:COG3210    736 GTGATL 741
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 34-579 1.18e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 55.16  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   34 AGVAVALSLAAVTSVPALAADTVVQAGetvNGGTLTNHDNQIVFGTANGMTISTGleyGPDNEANTGGQWIQNGGIANNT 113
Cdd:COG3210    790 AGAEISIDITADGTITAAGTTAINVTG---SGGTITINTATTGLTGTGDTTSGAG---GSNTTDTTTGTTSDGASGGGTA 863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  114 TVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAE 193
Cdd:COG3210    864 GANSGSLAATAASITVGSGGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTT 943

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  194 GGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGhALDTTLNGGYQYVHNGGTASGTVVNSD 273
Cdd:COG3210    944 ALSGTQGNAGLSAASASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATG-ILVAGNSGTTASTTGGSGAIVAGGNGV 1022

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  274 GWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLESGGRLDVLE 353
Cdd:COG3210   1023 TGTTGTASATGTGTAATAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGGGGTAQASGAGTTHTLGGITNGGA 1102

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  354 GHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGGSFTVNAGGQAG 433
Cdd:COG3210   1103 TGTSGGTTTSTGGVTASKVGGTTTVGATGTSTASTEAAGAGTLTGLVAVSAVAGGASSASAGDTTAVAAATTTTTGSAIN 1182

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  434 NTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTN 513
Cdd:COG3210   1183 GGADSAATEGTAGTDLKGGDSTGGSTTTIGTTNVTTTTTLTASDTGNTTATGGSSAGQTGSFVAAGSASGTGDATTGATA 1262

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1850116604  514 LTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLGVATTGQGIRVVDAQNGATT 579
Cdd:COG3210   1263 GAVSNGATSTVAGNAGATATGSTVDIGSTSATSAGGSLDTTGNTAGANGATVGTGIGGTTATGTAV 1328
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 106-604 4.61e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 53.23  E-value: 4.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  106 NGGIANNTTVTGGGLQRVNA---GGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAM 182
Cdd:COG3210    795 SIDITADGTITAAGTTAINVtgsGGTITINTATTGLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATA 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  183 ATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNG 262
Cdd:COG3210    875 ASITVGSGGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGL 954

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  263 GTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVV 342
Cdd:COG3210    955 SAASASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGT 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  343 LESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGG 422
Cdd:COG3210   1035 GTAATAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGGGGTAQASGAGTTHTLGGITNGGATGTSGGTTTSTG 1114

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  423 SFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGDS 502
Cdd:COG3210   1115 GVTASKVGGTTTVGATGTSTASTEAAGAGTLTGLVAVSAVAGGASSASAGDTTAVAAATTTTTGSAINGGADSAATEGTA 1194

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  503 PVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLGVATTGQGIRVVDAQNGATTEEG 582
Cdd:COG3210   1195 GTDLKGGDSTGGSTTTIGTTNVTTTTTLTASDTGNTTATGGSSAGQTGSFVAAGSASGTGDATTGATAGAVSNGATSTVA 1274

                          490       500
                   ....*....|....*....|..
gi 1850116604  583 AFALSRPLQAGAFNYTLNRDSD 604
Cdd:COG3210   1275 GNAGATATGSTVDIGSTSATSA 1296
PL1_Passenger_AT cd01343
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of ...
 362-609 7.33e-07

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases, SPATEs (serine protease autotransporters secreted by Enterobacteriaceae), Bordetella pertacins, and nonprotease autotransporters, TibA and similar AIDA-like proteins.


Pssm-ID: 238653 [Multi-domain]  Cd Length: 233  Bit Score: 50.43  E-value: 7.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 362 VDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGqasglllenggsfTVNAGGqagNTTVGHRG 441
Cdd:cd01343    12 AGDNAQLTLGGGALYGSSVTLTNGAVLDAGNANLSAAASYATLSGSNIRG-------------TVVLGA---GQPLQALA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 442 TLTLAAGGSLSGRTQLSKG-ASMVLNGDVVSTGDIvnageiHFDNQTTQDavlSRAVAKGDSPVTFHKLTTTNLTGQGgT 520
Cdd:cd01343    76 ELLLGGNAAWTGAIQGLNAtVSLNLNSVWTLTGDS------NVNNLTLNG---GTVDFNGPSAGKFNTLTVNTLSGNG-T 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 521 INMRVRLDGsNTSDQLVINGgQATGKtwlaFTNVGNSNLGVATTGQGIRVVDAQNGatTEEGAFALSRPLQAGAFNYTLN 600
Cdd:cd01343   146 FVMRTDLAG-GQGDKLVVTG-SATGD----FNLLVVNTGKEPTSGLNLTLVSTPKG--GDAEFTLANGTVDLGAYRYTLV 217


                  ....*....
gi 1850116604 601 RDSDEDWYL 609
Cdd:cd01343   218 KDGNGNWTL 226
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 62-600 4.42e-06

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 50.15  E-value: 4.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   62 TVNGGTLTNHDNQIVFGTANGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQS 141
Cdd:COG3210    716 TGQIGALANANGDTVTFGNLGTGATLTLNAGVTITSGNAGTLSIGLTANTTASGTTLTLANANGNTSAGATLDNAGAEIS 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  142 LQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGR 221
Cdd:COG3210    796 IDITADGTITAAGTTAINVTGSGGTITINTATTGLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATAA 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  222 QIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNGGTASGTVV---NSDGWQIIKEGGLADFTTVNQKGKLQVN 298
Cdd:COG3210    876 SITVGSGGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGgltGGNAAAGGTGAGNGTTALSGTQGNAGLS 955

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  299 AGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATD 378
Cdd:COG3210    956 AASASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTG 1035

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  379 VTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLS 458
Cdd:COG3210   1036 TAATAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGGGGTAQASGAGTTHTLGGITNGGATGTSGGTTTSTGG 1115

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  459 KGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVI 538
Cdd:COG3210   1116 VTASKVGGTTTVGATGTSTASTEAAGAGTLTGLVAVSAVAGGASSASAGDTTAVAAATTTTTGSAINGGADSAATEGTAG 1195

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1850116604  539 NGGQATGKTWLAFTNVGNSNLGVATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLN 600
Cdd:COG3210   1196 TDLKGGDSTGGSTTTIGTTNVTTTTTLTASDTGNTTATGGSSAGQTGSFVAAGSASGTGDAT 1257
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 17-492 6.10e-06

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 49.39  E-value: 6.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  17 TGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTANGMTISTGLEYGPDNE 96
Cdd:COG4625    70 GGGGAGGGGGGGGGGGGGGGTGGVGGGGGGGGGGGGGGGGGGGGGGGGSAGGGGGGAGGAGGGGGGGAGGGGGGGGGGGA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  97 ANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQA 176
Cdd:COG4625   150 GGGGGGGAGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGNGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGGGGGGG 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 177 VKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGY 256
Cdd:COG4625   230 GGGGGGGGGGGGGGGGGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGGGGGGGGGGGGGGGGGGG 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 257 QYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENG 336
Cdd:COG4625   310 GGGGGGGGGGGGGGGGGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGGGGGGSGGGGAGGGGGSG 389

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 337 KADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGL 416
Cdd:COG4625   390 GGGGGGAGGGGGGGGAGGTGGGGAGGGGGAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGGGGGAGGSGGGAGAGGGS 469

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1850116604 417 LLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAV 492
Cdd:COG4625   470 GSGAGTLTLTGNNTYTGTTTVNGGGNYTQSAGSTLAVEVDAANSDRLVVTGTATLNGGTVVVLAGGYAPGTTYTIL 545
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 78-580 8.23e-06

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 49.01  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  78 GTANGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQW 157
Cdd:COG4625     4 GGGGGGGGGGGGGTGGGGAGGGGGAGGGAGGGGAGGGGGGGGGGGGAGGGGGGGGTGGGGGGGGGGGGGGAGGGGGGGGG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 158 VHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYA 237
Cdd:COG4625    84 GGGGGGTGGVGGGGGGGGGGGGGGGGGGGGGGGGSAGGGGGGAGGAGGGGGGGAGGGGGGGGGGGAGGGGGGGAGGAGGG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 238 GGDQTVHGHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTS 317
Cdd:COG4625   164 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGNGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 318 TAATVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEG 397
Cdd:COG4625   244 GGGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 398 TNASGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVN 477
Cdd:COG4625   324 GGGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGGGGGGSGGGGAGGGGGSGGGGGGGAGGGGGGG 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 478 AGEIHFDNQTTQDAVLSRAVAKGDSPVTFhKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNS 557
Cdd:COG4625   404 GAGGTGGGGAGGGGGAAGGGGGGTGAGGG-GGGGGTGAGGGGATGGGGGGGGGAGGSGGGAGAGGGSGSGAGTLTLTGNN 482

                         490       500
                  ....*....|....*....|...
gi 1850116604 558 NLGVATTGQGIRVVDAQNGATTE 580
Cdd:COG4625   483 TYTGTTTVNGGGNYTQSAGSTLA 505
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 41-531 9.04e-06

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 49.01  E-value: 9.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  41 SLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTANGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGL 120
Cdd:COG4625     5 GGGGGGGGGGGGTGGGGAGGGGGAGGGAGGGGAGGGGGGGGGGGGAGGGGGGGGTGGGGGGGGGGGGGGAGGGGGGGGGG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 121 QRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAEN 200
Cdd:COG4625    85 GGGGGTGGVGGGGGGGGGGGGGGGGGGGGGGGGSAGGGGGGAGGAGGGGGGGAGGGGGGGGGGGAGGGGGGGAGGAGGGG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 201 GDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKE 280
Cdd:COG4625   165 GGGGGGGGGGGGGGGGGGGGGGGGGGGGNGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 281 GGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKT 360
Cdd:COG4625   245 GGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 361 RVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHR 440
Cdd:COG4625   325 GGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGGGGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGG 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 441 GTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGT 520
Cdd:COG4625   405 AGGTGGGGAGGGGGAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGGGGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTY 484

                         490
                  ....*....|.
gi 1850116604 521 INMRVRLDGSN 531
Cdd:COG4625   485 TGTTTVNGGGN 495
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 34-579 1.44e-05

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 48.22  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   34 AGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTANGMTISTGLEYGPDNEANTGGQWIQNGGIANNT 113
Cdd:COG3210    338 NSGAGLVSGGTGGNNGTTGTGAGSGLTGTGNGGGLTTAGAGTVASTVGTATASTGNASSTTVLGSGSLATGNTGTTIAGN 417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  114 TVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQAVKSGAMATDTVVNTGAE 193
Cdd:COG3210    418 GGSANAGGFTTTGGVLGITGNGTVTGGTIGGLTGSGTTNGAGLSGNTDVSGTGTVTNSAGNTTSATTLAGGGIGTVTTNA 497

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  194 GGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNGGTASGTVVNSD 273
Cdd:COG3210    498 TISNNAGGDANGIATGLTGITAGGGGGGNATSGGTGGDGTTLSGSGLTTTVSGGASGTTAASGSNTANTLGVLAATGGTS 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  274 GWQIIKEGGLADFTTV--NQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLESGGRLDV 351
Cdd:COG3210    578 NATTAGNSTSATGGTGtnSGGTVLSIGTGSAGATGTITLGAGTSGAGANATGGGAGLTGSAVGAALSGTGSGTTGTASAN 657

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  352 LEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLENGGSFTVNAGGQ 431
Cdd:COG3210    658 GSNTTGVNTAGGTGGGTTGTVTSGATGGTTGTTLNAATGGTLNNAGNTLTISTGSITVTGQIGALANANGDTVTFGNLGT 737

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  432 AGNTTVGHRGTLTLAAGGSLSGRTQLSKGAS-----------------------MVLNGDVVSTGDIVNAGEIHFDNQTT 488
Cdd:COG3210    738 GATLTLNAGVTITSGNAGTLSIGLTANTTASgttltlanangntsagatldnagAEISIDITADGTITAAGTTAINVTGS 817

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  489 QDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLGVATTGQGI 568
Cdd:COG3210    818 GGTITINTATTGLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGSGGVATSTGTANAGTLT 897

                          570
                   ....*....|.
gi 1850116604  569 RVVDAQNGATT 579
Cdd:COG3210    898 NLGTTTNAASG 908
AIDA pfam16168
Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on ...
 402-460 1.55e-05

Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on bacterial autotransporter proteins. As the repeat is short and occurs multiple times, it is likely to be the region of the transporter that acts as the stalk between the beta-barrel inserted into the membrane and the N-terminal head domain.


Pssm-ID: 406554 [Multi-domain]  Cd Length: 57  Bit Score: 42.71  E-value: 1.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1850116604 402 GKFSIDGisGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKG 460
Cdd:pfam16168   1 GAFSISG--GVADNVLLENGGSLTVVAGTSATDTTVDKGGTLDVQSGGTATGTVVNNGG 57
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
224-612 2.27e-05

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 47.75  E-value: 2.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  224 VAAEGTANTTVVYAGGDQTVhghaldtTLNGGYQYVHNGGTASGTVVNSDGWQIikegglaDFTTVNQkgklQVNAGGTA 303
Cdd:PRK09752   542 IGGDGKDGVYVVIDAGDGQV-------SLANNNSYLGTTQIASGTLMVSDNSQL-------GDTHYNR----QVIFTDKQ 603

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  304 THVTLKQGGALVTSTAATVLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHsaqktRVDDGGTLAVSAGGKatdVTMTS 383
Cdd:PRK09752   604 QESVMEITADVDTRSTTTGHGRDIEMRADGEVAVDAGVDTQWGALMADSSGQ-----HQDEGSTLTKTGAGT---LELTA 675

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  384 GGAliADSGATVEGTNASGKfsIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGA-- 461
Cdd:PRK09752   676 SGT--TQSAVRVEEGTLKGD--VADIIPYASSLWVGDGATFVTGADQDIQSIDATSSGTIDISDGTVLRLTGQDTSVAln 751

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  462 SMVLNGD---VVSTGDIVNAGEIHFDNQTTQDAVLSRAVAKGD-----------SPVTFHKLTTTNLTGQGGTINMRVRL 527
Cdd:PRK09752   752 ASLFNGDgtlVNATDGVTLTGELNTNLETDSLTYLSDVTVNGNltntsgavslqNGVAGDTLTVNGDYTGGGTLLLDSEL 831

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  528 DGSNT-SDQLVINGGQAtGKTwlafTNVGNSNLGVAT-TGQGIRVVDAQNGAT----TEEGAFALSRPLQAGAFNYTLNR 601
Cdd:PRK09752   832 NGDDSvSDQLVLNGNTA-GNT----TVVVNSITGIGEpTSTGIKVVDFAADPTqfqnNAQFSLAGSGYVNMGAYDYTLVE 906

                          410
                   ....*....|.
gi 1850116604  602 DSDeDWYLRSE 612
Cdd:PRK09752   907 DNN-DWYLRSQ 916
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 505-611 5.25e-05

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 45.84  E-value: 5.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 505 TFHKLTTTNLTGQGGTINMRVRLDGSN-TSDQLVINGgQATGKTWLAFTNVGNSNlgvATTGQGIRVVDAQNGAtteEGA 583
Cdd:TIGR01414   4 AFNTLTVNGLYTGNGGFVMNTDLGGDNsQTDRLVVNG-NASGTTGVVVNNIGGEG---AQTGDGITLVTVNGGS---DAA 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1850116604 584 FALSRP-LQAGAFNYTLNRD---SDEDWYLRS 611
Cdd:TIGR01414  77 FTLANGkVDAGAYTYTLYKNgteDNNNWYLTS 108
auto_BafA_Cterm NF040482
BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and ...
 48-189 1.64e-04

BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and Bartonella quintana, and possibly all Bartonella BafA, are mitogenic autotransporter virulence factors that help induce vasoproliferative lesions during infection. This HMM represents the more conserved C-terminal portion only, as the passenger region is more highly variable in length and sequence.


Pssm-ID: 468508 [Multi-domain]  Cd Length: 617  Bit Score: 44.63  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  48 VPALAADTVVQAGetvnGGTLtnhDNQIVFGtaNGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGG 127
Cdd:NF040482    5 KGSSAYDTVIYGQ----GETL---GQQNVYD--GGIAWNTKVMQGGVQNVAKKSQSAKNGGFAFNTEVFGGGKQRVLAGG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1850116604 128 SvsdtvisagggqslqgqAVNTTLNGGE-QWVHEGGIATVTVINEKGWQAVKSGA-MATDTVVN 189
Cdd:NF040482   76 K-----------------AIGVTLNETAvQEIYAGGFVKNLTINDEAKSWVYAGAtLEGKTLVN 122
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 6-600 3.74e-04

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 43.99  E-value: 3.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604    6 NTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTANGMTI 85
Cdd:COG3210    591 GTGTNSGGTVLSIGTGSAGATGTITLGAGTSGAGANATGGGAGLTGSAVGAALSGTGSGTTGTASANGSNTTGVNTAGGT 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604   86 STGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAgGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIAT 165
Cdd:COG3210    671 GGGTTGTVTSGATGGTTGTTLNAATGGTLNNAGNTLTIST-GSITVTGQIGALANANGDTVTFGNLGTGATLTLNAGVTI 749

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  166 VTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENG---DTGQNVYGD-AVRTTINKNGRQIVAAEGTANTTVVYAGGDQ 241
Cdd:COG3210    750 TSGNAGTLSIGLTANTTASGTTLTLANANGNTSAGAtldNAGAEISIDiTADGTITAAGTTAINVTGSGGTITINTATTG 829

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  242 TVHGHALDTTLNGGYQYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAAT 321
Cdd:COG3210    830 LTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGSGGVATSTGTANAGTLTNLGTTTNAASGN 909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  322 VLGSNRLGNFTVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNAS 401
Cdd:COG3210    910 GAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAASASDGAGDTGASSAAGSSAVGTSANSAGSTGG 989

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  402 GKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEI 481
Cdd:COG3210    990 VIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAATAGGQNGVGVNASGISGGNAAALTASGTAGT 1069

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  482 HFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLGV 561
Cdd:COG3210   1070 TGGTAASNGGGGTAQASGAGTTHTLGGITNGGATGTSGGTTTSTGGVTASKVGGTTTVGATGTSTASTEAAGAGTLTGLV 1149

                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 1850116604  562 ATTGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLN 600
Cdd:COG3210   1150 AVSAVAGGASSASAGDTTAVAAATTTTTGSAINGGADSA 1188
PRK09945 PRK09945
hypothetical protein; Provisional
 104-423 1.35e-03

hypothetical protein; Provisional


Pssm-ID: 137602 [Multi-domain]  Cd Length: 418  Bit Score: 41.62  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 104 IQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQW-VHEGGIATVTVINEKGWQAVKSGAM 182
Cdd:PRK09945   35 VEAGGRAENTVVTGAGWLKVATGGIAKCTQYGNNGTLSVSDGAIATDIVQSEGGaISLSTLATVNGRHPEGEFSVDQGYA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 183 ATDTVVNTG---AEGGPDAE----NGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGG 255
Cdd:PRK09945  115 CGLLLENGGnlrVLEGHRAEkiilDQEGGLLVNGTTSAVVVDEGGELLVYPGGEASNCEINQGGVFMLAGKASDTLLAGG 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 256 YQYvHNGGTASGTVVNSDGWQIIKEGGLADFTTvNQKGKLQVNAGGTA-THVTLKQGGALVTSTAATVLGSNRLGNFTVE 334
Cdd:PRK09945  195 TMN-NLGGEDSDTIVENGSIYRLGTDGLQLYSS-GKTQNLSVNVGGRAeVHAGTLENAVIQGGTVILLSPTSADENFVVE 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 335 NGKADgvvLESGGRLDVLEGHSAqktrvddggTLAVSAGGKATDVTMTSGGALIADsGATVEGTNASgkFSIDGISGQAS 414
Cdd:PRK09945  273 EDRAP---VELTGSVALLDGASM---------IIGYGADLQQSTITVQQGGVLILD-GSTVKGDSVT--FSVGNINLNGG 337


                  ....*....
gi 1850116604 415 GLLLENGGS 423
Cdd:PRK09945  338 KLWLITGAA 346
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
184-611 1.78e-03

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 41.32  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 184 TDTVVNTGAEGGPDAENGD--TGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTT-LNGGYQYVH 260
Cdd:PRK15313   98 TVTVIQNSGTGSPGVIFGNdlTIRTQSANAANNGRDVDGIRTHGANTPDNPVFIITGDRTRIYVDGQDGDgINAGYNSLG 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 261 NGGTASGTVVNSDGWQIIKEGGLADFTTVN-----QKGKLQVNAGGTATHVTLKQGG-ALVTSTAATVLgsnRLGNftve 334
Cdd:PRK15313  178 QGWTGSANIYVGDDLYIKTTGSQGRGITANamrdaSRAKNTIVVGNRAHIVTTGDSSeGLRTGQSGSLI---RLGD---- 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 335 ngkaDGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSaGGKATDVTMTSGGALIADSgATVEGTNASGKFSIdgiSGQAS 414
Cdd:PRK15313  251 ----DATIETSGASSTGIYAASSSRTELGNNATITVN-GASAHAVYATNATVNLGEN-ATISVNSASKAASY---SKAPA 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 415 GLLLENGGSftVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDNQTTQDAVLS 494
Cdd:PRK15313  322 GLYALSRGA--INLAGGAAITMAGDNSSESYAISTETGGIVDGSSGGRFVIDGDIRAAGATAASGTLPQQNSTIKLNMTD 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 495 RAVAKGDSPVT--------------------FHKLTTTNLT-GQGGTIN-----------MRVRLDGSNTSDQLVING-- 540
Cdd:PRK15313  400 NSRWDGASYITsatagtgvisvqmsdatwnmTSSSTLTDLTlNSGATINfshedgepwqtLTINEDYVGNGGKLVFNTvl 479

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 541 -------------GQATGKTWLAFTNVGNSNlgvATTGQGIRVVdaqNGATTEEGAFALSRPLQAGAFNYTLNRDSdEDW 607
Cdd:PRK15313  480 ndddsetdrlqvlGNTSGNTFVAVNNIGGAG---AQTIEGIEIV---NVAGNSNGTFEKASRIVAGAYDYNVVQKG-KNW 552


                  ....
gi 1850116604 608 YLRS 611
Cdd:PRK15313  553 YLTS 556
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 17-485 1.83e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 41.30  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  17 TGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGTANGMTISTGLEYGPDNE 96
Cdd:COG4625    44 GGGGGGAGGGGGGGGTGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGTGGVGGGGGGGGGGGGGGGGGGGGGGGGSAGGGG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  97 ANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATVTVINEKGWQA 176
Cdd:COG4625   124 GGAGGAGGGGGGGAGGGGGGGGGGGAGGGGGGGAGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGNGGGGGGGGGG 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 177 VKSGAMATDTVVNTGAEGGPDAENGDTGQNVYGDAVRTTINKNGRQIVAAEGTANTTVVYAGGDQTVHGHALDTTLNGGY 256
Cdd:COG4625   204 GGGGGGGGGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGG 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 257 QYVHNGGTASGTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATHVTLKQGGALVTSTAATVLGSNRLGNFTVENG 336
Cdd:COG4625   284 GGGSGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGT 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604 337 KADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGL 416
Cdd:COG4625   364 GGGGGGGGGGGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGGAGGTGGGGAGGGGGAAGGGGGGTGAGGGGGGGGTGAGGG 443

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1850116604 417 LLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGEIHFDN 485
Cdd:COG4625   444 GATGGGGGGGGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTYTGTTTVNGGGNYTQSAGSTLAVEVDAAN 512
PRK15319 PRK15319
fibronectin-binding autotransporter adhesin ShdA;
513-612 5.63e-03

fibronectin-binding autotransporter adhesin ShdA;


Pssm-ID: 185219 [Multi-domain]  Cd Length: 2039  Bit Score: 40.07  E-value: 5.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850116604  513 NLTGQGGTINMRVRL-DGSNTSDQLVINgGQATGKTWLAFTNVGNSnlgvATTGQGIRVVDAqnGATTEEGAFALSRPLQ 591
Cdd:PRK15319  1572 NYTGNGGSLYLNTVLgDDDSATDKLVIT-GDASGTTDLYINGIGDG----AQTTNGIEVVDV--GGVSTSDAFELKNEVN 1644

                           90       100
                   ....*....|....*....|..
gi 1850116604  592 AGAFNYTLN-RDSDEDWYLRSE 612
Cdd:PRK15319  1645 AGLYTYRLYwNESDNDWYLASK 1666
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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