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Conserved domains on  [gi|1840080674|ref|WP_170102089|]
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phosphopyruvate hydratase [Megasphaera elsdenii]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 5-427 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 813.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   5 RIEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQ 84
Cdd:COG0148     3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALIGM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  85 DPFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDV 164
Cdd:COG0148    83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNVDI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 165 QEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALD 244
Cdd:COG0148   163 QEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALALD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 245 AAASEWKgpKQGVYVLPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTK 324
Cdd:COG0148   243 VAASEFY--KDGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTNPK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 325 RLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAK 404
Cdd:COG0148   321 RLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERVAK 400

                         410       420
                  ....*....|....*....|...
gi 1840080674 405 YNRLLQIEDELHGQGIYPGFQAF 427
Cdd:COG0148   401 YNQLLRIEEELGDAARYAGRSAF 423
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 5-427 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 813.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   5 RIEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQ 84
Cdd:COG0148     3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALIGM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  85 DPFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDV 164
Cdd:COG0148    83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNVDI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 165 QEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALD 244
Cdd:COG0148   163 QEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALALD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 245 AAASEWKgpKQGVYVLPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTK 324
Cdd:COG0148   243 VAASEFY--KDGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTNPK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 325 RLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAK 404
Cdd:COG0148   321 RLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERVAK 400

                         410       420
                  ....*....|....*....|...
gi 1840080674 405 YNRLLQIEDELHGQGIYPGFQAF 427
Cdd:COG0148   401 YNQLLRIEEELGDAARYAGRSAF 423
eno PRK00077
enolase; Provisional
 5-427 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 766.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   5 RIEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQ 84
Cdd:PRK00077    3 KIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALIGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  85 DPFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDV 164
Cdd:PRK00077   83 DALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNVDI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 165 QEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALD 244
Cdd:PRK00077  163 QEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALALD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 245 AAASE-WKGpkqGVYVLpkSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNT 323
Cdd:PRK00077  243 CAASEfYKD---GKYVL--EGEGLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTNT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 324 KRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVA 403
Cdd:PRK00077  318 KRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIA 397

                         410       420
                  ....*....|....*....|....
gi 1840080674 404 KYNRLLQIEDELHGQGIYPGFQAF 427
Cdd:PRK00077  398 KYNQLLRIEEELGDAARYAGKKAF 421
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 6-427 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 693.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   6 IEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQD 85
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  86 PFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDVQ 165
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 166 EFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALDA 245
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 246 AASEWKGPKQGVYVLPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTKR 325
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTEI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 326 LAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAKY 405
Cdd:TIGR01060 321 LREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKY 400

                         410       420
                  ....*....|....*....|..
gi 1840080674 406 NRLLQIEDELHGQGIYPGFQAF 427
Cdd:TIGR01060 401 NQLLRIEEELGDSARYAGKNSF 422
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 8-414 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 690.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   8 KVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQDPF 87
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  88 DTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDVQEF 167
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 168 MIMPAGAPSFREGLRWCSEVYHALAGLLKAKG--LATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALDA 245
Cdd:cd03313   161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 246 AASEWKGPKQGVYVlPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTKR 325
Cdd:cd03313   241 AASEFYDEGKYVYD-SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 326 LAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAKY 405
Cdd:cd03313   320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399


                  ....*....
gi 1840080674 406 NRLLQIEDE 414
Cdd:cd03313   400 NQLLRIEEE 408
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
144-423 2.21e-145

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 415.72  E-value: 2.21e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 144 LPVPMMNILNGGAHAANTVDVQEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKG--LATSVGDEGGFAPNLASDEEAI 221
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNKEAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 222 QYILQAIEKAGYEPgkDFVLALDAAASEWKGPKQGVYVL------PKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEE 295
Cdd:pfam00113  84 DLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLdfkgekSDKSKKLTSAQLADLYEELVKKYPIVSIEDPFDED 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 296 DWDGWTALTKALGQRVQLVGDDLFVTNTKRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETE 375
Cdd:pfam00113 162 DWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGETE 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1840080674 376 DTSIADLAVALNTAQIKSGAPNRSERVAKYNRLLQIEDELHGQGIYPG 423
Cdd:pfam00113 242 DTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAG 289
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 5-427 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 813.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   5 RIEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQ 84
Cdd:COG0148     3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALIGM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  85 DPFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDV 164
Cdd:COG0148    83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNVDI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 165 QEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALD 244
Cdd:COG0148   163 QEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALALD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 245 AAASEWKgpKQGVYVLPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTK 324
Cdd:COG0148   243 VAASEFY--KDGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTNPK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 325 RLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAK 404
Cdd:COG0148   321 RLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERVAK 400

                         410       420
                  ....*....|....*....|...
gi 1840080674 405 YNRLLQIEDELHGQGIYPGFQAF 427
Cdd:COG0148   401 YNQLLRIEEELGDAARYAGRSAF 423
eno PRK00077
enolase; Provisional
 5-427 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 766.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   5 RIEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQ 84
Cdd:PRK00077    3 KIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALIGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  85 DPFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDV 164
Cdd:PRK00077   83 DALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNVDI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 165 QEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALD 244
Cdd:PRK00077  163 QEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALALD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 245 AAASE-WKGpkqGVYVLpkSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNT 323
Cdd:PRK00077  243 CAASEfYKD---GKYVL--EGEGLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTNT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 324 KRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVA 403
Cdd:PRK00077  318 KRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIA 397

                         410       420
                  ....*....|....*....|....
gi 1840080674 404 KYNRLLQIEDELHGQGIYPGFQAF 427
Cdd:PRK00077  398 KYNQLLRIEEELGDAARYAGKKAF 421
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 6-427 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 693.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   6 IEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQD 85
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  86 PFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDVQ 165
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 166 EFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKGLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALDA 245
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 246 AASEWKGPKQGVYVLPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTKR 325
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTEI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 326 LAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAKY 405
Cdd:TIGR01060 321 LREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKY 400

                         410       420
                  ....*....|....*....|..
gi 1840080674 406 NRLLQIEDELHGQGIYPGFQAF 427
Cdd:TIGR01060 401 NQLLRIEEELGDSARYAGKNSF 422
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 8-414 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 690.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   8 KVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQDPF 87
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  88 DTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNGGAHAANTVDVQEF 167
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 168 MIMPAGAPSFREGLRWCSEVYHALAGLLKAKG--LATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEPGKDFVLALDA 245
Cdd:cd03313   161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 246 AASEWKGPKQGVYVlPKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKALGQRVQLVGDDLFVTNTKR 325
Cdd:cd03313   241 AASEFYDEGKYVYD-SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 326 LAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSGAPNRSERVAKY 405
Cdd:cd03313   320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399


                  ....*....
gi 1840080674 406 NRLLQIEDE 414
Cdd:cd03313   400 NQLLRIEEE 408
PTZ00081 PTZ00081
enolase; Provisional
 6-423 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 533.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   6 IEKVIGREILDSRGNPTVQADVLLSDGTLgRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQD 85
Cdd:PTZ00081    4 IKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALIGKD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  86 PFDTYGVDSLMIHA-DGTPD-----KSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNY-----LPVPMMNILNG 154
Cdd:PTZ00081   83 VTDQKKLDKLMVEQlDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKPtdkfvLPVPCFNVING 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 155 GAHAANTVDVQEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAK-GL-ATSVGDEGGFAPNLASDEEAIQYILQAIEKAG 232
Cdd:PTZ00081  163 GKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKyGLdATNVGDEGGFAPNIKDPEEALDLLVEAIKKAG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 233 YEpGKdFVLALDAAASEWKGPKQGVYVL----PKSGQS--FTTDELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKA 306
Cdd:PTZ00081  243 YE-GK-VKICMDVAASEFYDKEKKVYDLdfknPNNDKSnkLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAKLTAA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 307 LGQRVQLVGDDLFVTNTKRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVAL 386
Cdd:PTZ00081  321 IGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLVVGL 400

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1840080674 387 NTAQIKSGAPNRSERVAKYNRLLQIEDELHGQGIYPG 423
Cdd:PTZ00081  401 GTGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAG 437
PLN00191 PLN00191
enolase
 6-423 3.89e-179

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 507.71  E-value: 3.89e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   6 IEKVIGREILDSRGNPTVQADVLLSDGTLgRSAAPSGASTGQFEALELRDGDvQRFGGKGVTQTVSHVNTVLQDVLRGQD 85
Cdd:PLN00191   28 ITKVKARQIIDSRGNPTVEVDLHTSKGMF-RAAVPSGASTGIYEALELRDGD-KDYLGKGVLKAVKNVNEIIAPALIGMD 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  86 PFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGN---YLPVPMMNILNGGAHAANTV 162
Cdd:PLN00191  106 PTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAGNkklVLPVPAFNVINGGSHAGNKL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 163 DVQEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAK--GLATSVGDEGGFAPNLASDEEAIQYILQAIEKAGYEpGKdFV 240
Cdd:PLN00191  186 AMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKygQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT-GK-IK 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 241 LALDAAASEWKGPKqGVYVL-----PKSGQSFTT-DELIAHWQKLSQAYPIYSIEDGLDEEDWDGWTALTKalGQRVQLV 314
Cdd:PLN00191  264 IGMDVAASEFYTKD-KKYDLdfkeeNNDGSNKKSgDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTS--LEDVQIV 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 315 GDDLFVTNTKRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETEDTSIADLAVALNTAQIKSG 394
Cdd:PLN00191  341 GDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQIKTG 420

                         410       420
                  ....*....|....*....|....*....
gi 1840080674 395 APNRSERVAKYNRLLQIEDELHGQGIYPG 423
Cdd:PLN00191  421 APCRSERLAKYNQLLRIEEELGDEAVYAG 449
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
144-423 2.21e-145

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 415.72  E-value: 2.21e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 144 LPVPMMNILNGGAHAANTVDVQEFMIMPAGAPSFREGLRWCSEVYHALAGLLKAKG--LATSVGDEGGFAPNLASDEEAI 221
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNKEAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 222 QYILQAIEKAGYEPgkDFVLALDAAASEWKGPKQGVYVL------PKSGQSFTTDELIAHWQKLSQAYPIYSIEDGLDEE 295
Cdd:pfam00113  84 DLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLdfkgekSDKSKKLTSAQLADLYEELVKKYPIVSIEDPFDED 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 296 DWDGWTALTKALGQRVQLVGDDLFVTNTKRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAIVSHRSGETE 375
Cdd:pfam00113 162 DWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGETE 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1840080674 376 DTSIADLAVALNTAQIKSGAPNRSERVAKYNRLLQIEDELHGQGIYPG 423
Cdd:pfam00113 242 DTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAG 289
Enolase_N pfam03952
Enolase, N-terminal domain;
6-136 3.77e-69

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 214.93  E-value: 3.77e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   6 IEKVIGREILDSRGNPTVQADVLLSDGTLGRSAAPSGASTGQFEALELRDGDVQRFGGKGVTQTVSHVNTVLQDVLRGQD 85
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1840080674  86 PFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFL 136
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 195-391 1.05e-14

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 73.13  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 195 LKAKGLATSVGDEGGFAPN----LASDEEAIQYILQAIekagyepGKDFVLALDAAasewkgpkqgvyvlpksgQSFTTD 270
Cdd:cd00308    54 LAAKALGVPLAELLGGGSRdrvpAYGSIERVRAVREAF-------GPDARLAVDAN------------------GAWTPK 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 271 ELIAHWQKLSQaYPIYSIEDGLDEEDWDGWTALTKALGqrVQLVGDDLFVTNTKRLaKGIAQGCGNAILIKLNQIGSVSE 350
Cdd:cd00308   109 EAIRLIRALEK-YGLAWIEEPCAPDDLEGYAALRRRTG--IPIAADESVTTVDDAL-EALELGAVDILQIKPTRVGGLTE 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1840080674 351 TLEAIKMAHRAGYRAIVSHRSG-ETEDTSIADLAVALNTAQI 391
Cdd:cd00308   185 SRRAADLAEAFGIRVMVHGTLEsSIGTAAALHLAAALPNDRA 226
PRK08350 PRK08350
hypothetical protein; Provisional
 6-154 1.65e-11

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 65.21  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674   6 IEKVIGREILDSRGNPTVQADVLLSDGtLGRSAAPSGastgqfEALELRDGDVQRfggkgvtqTVSHVNTVLQDVLRGQD 85
Cdd:PRK08350    4 IENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPID------ENPSLYIAEAHR--------AVSEVDEIIGPELIGFD 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1840080674  86 PFDTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNYLPVPMMNILNG 154
Cdd:PRK08350   69 ASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTTELPVPILEFAED 137
PTZ00378 PTZ00378
hypothetical protein; Provisional
 88-427 2.25e-05

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 46.41  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674  88 DTYGVDSLMIHADGTPDKSRLGANAILAVSLACARAAAASLGIPLYRFLGGVNGNY-----LPVPMMNILNGGAHAANTV 162
Cdd:PTZ00378  126 DQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRSVPLFQYLRALFGSLtsvetFSMPQLCITFFGPGNPSTA 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 163 -----DVQEFMIMPAGAPSfREGLRwcsEVYHALAGLLKAKglATSVGDEGGF----APNLAsdeEAIQYILQAIEKAGY 233
Cdd:PTZ00378  206 rlalkSVLFSPVMPSGTVL-RERMQ---KIFAAFHHFCQSH--NSSVRSDGSLhwdgFANLT---DAVKLATEALRAVQL 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 234 EPGKDFVLALDAAAS-------------EWKGPKQG---VYVLPKSGQSFTTDELIAHWQKLSQAYP--IYSIEDGLDEE 295
Cdd:PTZ00378  277 TPGTDVCLGLRMAASttrvpatavadggAWKEAKDDcevLYSLFPGEPDVTGDQLSEYVREQLQAVPdiVVYVEDTHCDE 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 296 DWDGWTALTKALGQRVQLVGDDLFV-TNTKRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAGYRAI-VSHRSGE 373
Cdd:PTZ00378  357 DTFGLQRLQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIVLNPCAIGTLSDVVEIVRAVGEDEGRAVtVLVQTLA 436

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1840080674 374 TEDTSIADLAVALNTAQIKSGAPNRSERVAKYNRLLQIEDEL-HGQGIYPGFQAF 427
Cdd:PTZ00378  437 GNAATAAHLAVAMGARFLCSGGLFSAHQCEVVSQLASRQDELtHSRMLAPEAPKF 491
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
 127-362 1.42e-04

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 43.66  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 127 SLGIPLYRFLGGVNGNYLPVpmmnilnGGAHAANTVDVqefMImpagapsfREGLRWCSEVYHALagllKAKGlatsvgd 206
Cdd:COG4948   110 ALGVPVYQLLGGKVRDRVPV-------YATLGIDTPEE---MA--------EEAREAVARGFRAL----KLKV------- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840080674 207 eggFAPNLASDEEAIQYILQAIekagyepGKDFVLALDAaasewkgpkqgvyvlpksGQSFTTDELIAHWQKLsQAYPIY 286
Cdd:COG4948   161 ---GGPDPEEDVERVRAVREAV-------GPDARLRVDA------------------NGAWTLEEAIRLLRAL-EDLGLE 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1840080674 287 SIEDGLDEEDWDGWTALTKALgqRVQLVGDDLfVTNTKRLAKGIAQGCGNAILIKLNQIGSVSETLEAIKMAHRAG 362
Cdd:COG4948   212 WIEQPLPAEDLEGLAELRRAT--PVPIAADES-LTSRADFRRLIEAGAVDIVNIKLSKVGGLTEALRIAALAEAHG 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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