|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
21-388 |
7.78e-116 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 341.83 E-value: 7.78e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 21 IVLLGFVSLLGDMTYEGARSITGPYLSLLGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALTIIGYAVNLLAVP 100
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 101 LLALAGNWPMAALLLIAERMGKAIRTPPRDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVY-GNYQTGFA 179
Cdd:cd17370 81 LLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLgGNYRTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 180 FLLLPAILALAVLVTSKFLYPHPHDLEVQVPKLKTKGLMKVYWIYIVAVVFIALGFADFPLVAYHFQKVQLvAPVMIPIF 259
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGL-SAALIPLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 260 YSVAMGVDALAALLFGRLFDKMGMWALIMAVMCSAFFAPMVFWG--DFNLALLGMALWGVGMGAQESIMRAAVAEMSPVK 337
Cdd:cd17370 240 YALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALgsSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1839864444 338 VRGSAYGVFSIIYGFSWFAGSFILGLLYD-FSFTAMVMFSLGAQLLSVMPLF 388
Cdd:cd17370 320 LRGTAYGLFNTVVGIGWLLASLIAGYLWDlISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-391 |
2.24e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.57 E-value: 2.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 26 FVSLLGDMTYEGARS-ITGPYLSLLGASAAAVGFVSGFGELVGYSLRFASGYLADKsRQYWALTIIGYAVNLLAVPLLAL 104
Cdd:cd17325 2 SLALFLDMLGYGIIIpILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 105 AGNWPMAALLLIAERMGKAIRTPPRDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVYGnYQTGFAFLLLP 184
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 185 AILALAVLV-----TSKFLYPHPHDLEVQVPKLKTKGLMKVYWIYIVAVVFIALGFADF-PLVAYHFQKVQLVAPVMIPI 258
Cdd:cd17325 160 ALLALVLALlllpePRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALePFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 259 FYSVAMGVDALAALLFGRLFDKMGMWALIMAVM--CSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPV 336
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLllSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1839864444 337 KVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAMVMFSLGAQLLSVMPLFVIR 391
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-391 |
2.10e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 76.88 E-value: 2.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 49 LGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALtIIGYAVNLLAVPLLALAGNWPMAALLLIAERMGKAIRTPP 128
Cdd:cd17329 30 LGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVM-LAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 129 RDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVYGNYQTGFAFLL-LPAILALAVLVTSKFLYPHPHDLEV 207
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLfLLAALVLLFLLPETRPKRRAAEKTE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 208 QVPKLKTKGLMKVYWIYIVAVVFIALGFADF-PLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMGMWAL 286
Cdd:cd17329 189 ILRGYKIVLRDRAFLLFLLASFLISLIYFQLeSTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 287 IMA--VMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLL 364
Cdd:cd17329 269 LMIgiLLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348
|
330 340
....*....|....*....|....*..
gi 1839864444 365 YDFSFTAMVMFSLGAQLLSVMPLFVIR 391
Cdd:cd17329 349 LDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-352 |
7.29e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.23 E-value: 7.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 21 IVLLGFVSLLGDMTYEGARSITGPYLSLLGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALtIIGYAVNLLAVP 100
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-LLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 101 LLALAGNWPMAALLLIAERMGKAIRTPPRDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVYGnYQTGFAF 180
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 181 LLLPAILALAVLVtskFLYPHPHDLEVQVPKLKTKGLMKVYWIYIVAVVFIALGFADFPLVAY---HFQKVQLVAPVMIP 257
Cdd:COG2814 170 NAVLALLALLLLL---RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYlplYLQEVLGLSASAAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 258 IFYSVAMGVDALAALLFGRLFDKMGMWALIMA--VMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSP 335
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIglLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330
....*....|....*..
gi 1839864444 336 VKVRGSAYGVFSIIYGF 352
Cdd:COG2814 327 PEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
49-358 |
4.11e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 66.67 E-value: 4.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 49 LGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALtIIGYAVNLLAVPLLALAGNWPMAALLLIAERMGKAIRTPP 128
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL-LIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 129 RDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVYGNY-----QTGFAFLLLPAILALAVLVTSKFLYPHPH 203
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRaafliLAILSLLAAVLLLLPRPPPESKRPKPAEE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 204 DLEVQVPKLKTKGLMKVYWIYIVAVVFIALGFADFPLVAyHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMG- 282
Cdd:pfam07690 186 ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGr 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 283 ----MWALIMAVMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGS 358
Cdd:pfam07690 265 rrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-385 |
2.01e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 64.76 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 24 LGFVSLLGDMTYEGARSITGPYLSLLGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALtIIGYAVNLLAVPLLA 103
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVL-LLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 104 LAGNWPMAALLLIAERMGKAIRTPPRDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIV-AIILYVYGNYQTGFAFLL 182
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGgILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 183 LPAILALAVLVTSKFLYPHPHDLEVQVPKLKTKGLM-------KVYWIYIVAVVFIALGF-ADFPLVAYHFQKVQLVAPV 254
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLlkrvlknPGLWLLLLAIFLVNLAYySFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 255 MIPIFYSVAMGVDALAALLFGRLFDKMG---MWALIMAVMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVA 331
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIgrkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1839864444 332 EMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYD--FSFTAMVMFSLGAQLLSVM 385
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAatFGLTGAFLVLAVLLLLAAI 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-368 |
3.62e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 3.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 30 LGDMTYEGARSITGPYLSL-----LGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYW-------ALTIIGYAVNLL 97
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYfytdvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiLIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 98 ---AVPLLALAGNWPMAALLLIAERMGKAIRTPPRDVMLSHATSQVG-RGWGFGLHEAMDQIGAILGPLIVAIILYVYG- 172
Cdd:COG2211 97 llfTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 173 NYQTGFAFLLLPA--ILALAVLVTSKFLYPHPHDLEVQVPKLKTKGLM---KVYWIYIVAVVFIALGFA-DFPLVAYHFQ 246
Cdd:COG2211 177 DAALGYRLTALIFavLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALlknRPFLLLLLAYLLFFLALAlVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 247 KVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMG---MWALIMAVMCSAFFAPMVF-WGDFNLALLGMALWGVGMGAQ 322
Cdd:COG2211 257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGkkkAFIIGLLLAALGLLLLFFLgPGNLWLLLVLAALAGIGLGAI 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1839864444 323 ESIMRAAVAEMSP-------VKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFS 368
Cdd:COG2211 337 LVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
222-384 |
9.89e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.47 E-value: 9.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 222 WIYIVAVVFIALG-FADFPLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMGMWALIMA--VMCSAFFAP 298
Cdd:cd17329 2 WVLLIGSFLNRLGfFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAglLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 299 MVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAMVMFSLG 378
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161
|
....*.
gi 1839864444 379 AQLLSV 384
Cdd:cd17329 162 LFLLAA 167
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-391 |
1.71e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.65 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 20 FIVLLGFVSLLGDMTYEGARSITGPYL-SLLGASAAAVGFVSGFGeLVGYSL-RFASGYLADKSRQYWALTIIGyAVNLL 97
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLqADLGLSAAQLGLLASAF-FLGYALgQIPAGLLADRFGRRRVLAIGL-LLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 98 AVPLLALAGNWPMAALLLIAERMGKAIRTPPRDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVYGnYQTG 177
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 178 FAFLLLPAILALAVLVTskflyphphdlevqvpklktkglmkVYWIYIVAVVFIALGFADFpLVAYhFQKVQLVAPVMIP 257
Cdd:COG2271 167 FLILGLPGLLLALLRFW-------------------------LLALAYFLVYFALYGFLTW-LPTY-LVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 258 IFYSVAMGVDALAALLFGRLFDKMG----MWALIMAVMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEM 333
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGrrrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1839864444 334 SPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYD-FSFTAMVMFSLGAQLLSVMPLFVIR 391
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDaTGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-384 |
3.29e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 3.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 24 LGFVSLLGDMTYEGARSITGPYLSLLGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALtIIGYAVNLLAVPLLA 103
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLL-LIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 104 LAGNWPMAALLLIAERMGKAIRTPprdVMLSHATSQVG---RGWGFGLHEAMDQIGAILGPLIvAIILYVYGNYQTGFAF 180
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTT---AAATLVADIIPpsrRGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 181 LLLPAILALAVLVTSKFLYPHPHDLEVQVPKLKTKGLMKVYWIYIVAVVFIALGFADF----PLVAYHfqkvqlVAPVMI 256
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIstflPLYAAE------RGISNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 257 PIFYSVAMGVDALAALLFGRLFDKMGMWALIMAVMCSAFFAPMVFW--GDFNLALLGMALWGVGMGAQESIMRAAVAEMS 334
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSfaGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1839864444 335 PVKVRGSAYGVFSIIYGFSWFAGSFILGLLYD-FSFTAMVMFSLGAQLLSV 384
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAElFGYRAMFLLAAVVVLLAL 360
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
200-390 |
1.71e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 200 PHPHDLEVQVPKLKTKGLMKVYWIYIVAVVFIALGFADFPLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFD 279
Cdd:cd17473 179 KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 280 KMG---MWALIMAVMCSAFFApMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFA 356
Cdd:cd17473 259 RLGkrrLLAIGFALMALGFLL-LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFL 337
|
170 180 190
....*....|....*....|....*....|....
gi 1839864444 357 GSFILGLLYDFSFTAMVMFSLGAQLLSVMPLFVI 390
Cdd:cd17473 338 SPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
142-395 |
2.43e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 142 RGWGFGLHEAMDQIGAILGPLIVAIILYVYGNYQTGFAFLLLPAILALAVLVTSKFLYPHPHDLEVQVPK-----LKTKG 216
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRdqleaLRDPR 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 217 LMKVYWIYIVAV-VFIALGFAdFPLVAYHFQKVQLVAPVMIPIFYSVAMgvdALAALLFGRLFDKMG---MWALIMAVMC 292
Cdd:COG2223 207 FWLLSLLYFGTFgSFIGFSSW-LPPYLVDQFGLSAATAGLLAALFALLG---ALGRPLGGWLSDRIGgrrVLLIVFALMA 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 293 SAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAM 372
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362
|
250 260
....*....|....*....|...
gi 1839864444 373 VMFSLGAQLLSVMPLFVIRNYRP 395
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
219-384 |
3.67e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.78 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 219 KVYWIYIVAVVFIALGFADFPLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMGMWALIMA--VMCSAFF 296
Cdd:cd17324 199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAllLLAAALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 297 APMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPvKVRGSAYGVFSIIYGFSWFAGSFILGLLYD-FSFTAMVMF 375
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDhGGWAGVGWV 357
|
....*....
gi 1839864444 376 SLGAQLLSV 384
Cdd:cd17324 358 GAALLLLAL 366
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
256-390 |
6.80e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 50.92 E-value: 6.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 256 IPIFYSVAMGVDALAALLFGRLFDKMG-----MWALI--MAVMCSAFFAP--MVFWgdfnlalLGMALWGVGMGAQESIM 326
Cdd:COG2270 276 LIVFGLLVQIVAALGALLFGRLDDRIGpkrviLVSLViwIVVCLAAYFLTtaLAFW-------ILGLLIGLVMGGIQALS 348
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839864444 327 RAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSftamvmfslGAQ---LLSVMPLFVI 390
Cdd:COG2270 349 RSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLT---------GSQrlgILSLIVFFVI 406
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
222-388 |
7.19e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 7.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 222 WIYIVAVVFIALGFADFPLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMGMWALIMA--VMCSAFFAPM 299
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLglLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 300 VFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYD-FSFTAMVMFSLG 378
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAV 172
|
170
....*....|
gi 1839864444 379 AQLLSVMPLF 388
Cdd:COG2814 173 LALLALLLLL 182
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-379 |
1.16e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 49 LGASAAAVGFVSGFGELVGYSLRFASGYLADK--SRQYWALTIIGYAVNLLAVPLLALAGNWPMAALLLIAERMG--KAI 124
Cdd:cd06173 29 LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRfdRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGiaSAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 125 RTPPRDVMLSHATSQVGRGWGFGLHEAMDQIGAILGPLIvAIILYVYGNYQTGFAFLLLPAILALAVLVTSKFLYPHPHD 204
Cdd:cd06173 109 FGPARQALLPELVPKEQLVRANALNSLATQLARIIGPAL-GGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 205 LEVQVPKLKTKGLMKVYW-------IYIVAVVFIALGFADFPLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRL 277
Cdd:cd06173 188 ESSSLLLRDLREGLRYLRrspllrlLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 278 --FDKMGMWALIMAVMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWF 355
Cdd:cd06173 268 skRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMP 347
|
330 340
....*....|....*....|....
gi 1839864444 356 AGSFILGLLYDFSFTAMVMFSLGA 379
Cdd:cd06173 348 LGALLAGLLADALGLSAVFLLAGA 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
223-395 |
3.93e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 3.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 223 IYIVAVVFIALGFADFPLVAYHFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMG--MWALIMAVMCSAFFAPMV 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGrrRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 301 FWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYD-FSFTAMVMFSLGA 379
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160
|
170
....*....|....*.
gi 1839864444 380 QLLSVMPLFVIRNYRP 395
Cdd:pfam07690 161 SLLAAVLLLLPRPPPE 176
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
223-366 |
1.86e-04 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 43.41 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 223 IYIVAVVFIALGFADFPLVAYHFQKVQL-VAPVMIPIFYSVAMGVDALAALLFGRLFDKMGMWALIMAVMCSAFFAPMVF 301
Cdd:pfam11700 287 LFLVAWFLLSDGIATVSSTAVLFAKTELgMSTSQLTLLNIVAMIAAVLGAFLWPFVSRRFNLKTKQTLIACIVLFELIPL 366
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1839864444 302 WG--DFNLALLGM----------ALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSII-YGFSWFaGSFILGLLYD 366
Cdd:pfam11700 367 YGllGIILGKIGLknpwefwvlqAFYGLVLGGLRSYSRSLYSELIPRGKEAQFFSLYAITdKGSSWI-GPLIVGAIQD 443
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-364 |
5.42e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 24 LGFVSLLGDMtYEGARSITGPYL-SLLGASAAAVGFVSGFGELVGYSLRFASGYLADKSRQYWALtIIGYAVNLLAVPLL 102
Cdd:cd17478 1 LSLGHFLNDF-YQGFLPALLPLLiAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLL-PLGPLLTGLGLSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 103 ALAGNWPMAALLLIAERMGKAIRTPPRDVMLSHAtSQVGRGWGFGLHEAMDQIGAILGPLIVAIILYVYGNYQTGFAFLL 182
Cdd:cd17478 79 GFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 183 LPAILALAVLVTSKFLYPHPHDLEVQVPKLKTKGLMKVYWIYIVAVVF----IALGFADF--PLVAYHFQKVQLVAPVMi 256
Cdd:cd17478 158 PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFlrswVLSSLTTFlpFYLVQRGYSLVFAGLLL- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 257 pifySVAMGVDALAALLFGRLFDKMGMWALIMAVM-CSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSP 335
Cdd:cd17478 237 ----SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLlLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP 312
|
330 340
....*....|....*....|....*....
gi 1839864444 336 vkvrGSAYGVFSIIYGFSWFAGSFILGLL 364
Cdd:cd17478 313 ----GNVGLASGLMMGLSFGLGGIGAPVL 337
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
258-388 |
9.18e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.02 E-value: 9.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 258 IFYSVAMGVDALAALLFGRLFDKMG--MWALIMAVMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSP 335
Cdd:COG2223 44 LLFAIPVLVGALLRIPLGFLVDRFGprRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1839864444 336 VKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAMVMFSLGAQLLSVMPLF 388
Cdd:COG2223 124 PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
255-390 |
1.77e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 255 MIPIFYSVAMGVDALAALLFGRLFDKMG--MWALIMAVMCSAFFAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAE 332
Cdd:cd06174 32 QLGLLFALFSLGYALLQPLAGLLADRFGrrPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1839864444 333 MSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAMVMFSLGAQLLSVMPLFVI 390
Cdd:cd06174 112 LFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILL 169
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
142-382 |
5.38e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 142 RGWGFGLHEAMDQIGAILGPLIVAIILYVYGNYqtgfaFLLLPAILALAVLVTSKFLYPHPHDLEVQVPKLKTKGLMKVY 221
Cdd:cd17474 121 RAKAMGLYEAALGLGIAVGPLLGGLLAAISWRY-----PFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKAL 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 222 ---WIYIVAVVFIALGFADFPLVAY---HFQKVQLVAPVMIPIFYSVAMGVDALAALLFGRLFDKMGMWALIMAVMCSAF 295
Cdd:cd17474 196 rgrGLLTFLVSAFLYFFLYFAFLTYlpfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 296 ---FAPMVFWGDFNLALLGMALWGVGMGAQESIMRAAVAEMSPVKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAM 372
Cdd:cd17474 276 alsLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
|
250
....*....|
gi 1839864444 373 VMFSLGAQLL 382
Cdd:cd17474 356 PFLVGAAIAL 365
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
253-379 |
9.59e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 37.87 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 253 PVMIPIFY---------------SVAMGVDALAALLFGRLFDKMG-----MW--ALIMAVMCSAF-FAPMVFWGDFNLAL 309
Cdd:cd17337 228 PVFMPLYFtdtggfstsqwlqiwGIIFLVNIFFNLIFGILGDKIGwrrtvRWfgGVGCAISTLLFyYVPQLFGHNYWAAL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839864444 310 LGMALWGVGMGAQeSIMRAAVAEMSPvKVRGSAYGVFSIIYGFSWFAGSFILGLLYDFSFTAMVMFSLGA 379
Cdd:cd17337 308 IAAILFGIGLAGF-VPLSALMPSLAP-EHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAG 375
|
|
| |
