|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-396 |
8.46e-82 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 255.66 E-value: 8.46e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 13 MLMGSAIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLL 92
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 93 LMAVSSTGWLLNLSAGLILGLALSATSFPILLSAVGRAAhPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALV 172
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWF-ERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 173 VSAILMTLLIPLAWTLKAPMYTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGF 252
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 253 NATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNG 332
Cdd:cd17355 243 SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1832152327 333 IVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWVHFFV 396
Cdd:cd17355 323 LAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-396 |
5.27e-47 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 165.44 E-value: 5.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 13 MLMGSAIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLL 92
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 93 LMAVSSTGWLLnLSAGLILGLALsATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALV 172
Cdd:COG2223 86 LLALAVSYWLL-LLLGLLLGIGG-GGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 173 VSAILMTLLIPLAWtlkapMYTDPNAATTKPQPALTFKQILVIAKNhKPFWFLSLGFFVCGFQVVFIGIHLPGYLID-HG 251
Cdd:COG2223 164 ILGILLLVVAVLAW-----LFLRDPPAGAAAAAKASLRDQLEALRD-PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 252 FNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTN 331
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1832152327 332 GIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWVHFFV 396
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-392 |
2.32e-27 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.89 E-value: 2.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 18 AIILALSLGVRHAF---GLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLM 94
Cdd:COG2807 21 LAIVLVALNLRPAItsvGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 95 AVSSTGWLLNLSAGLI-LGLALSatsfPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVV 173
Cdd:COG2807 101 SLAPSVALLLAGTALIgAGIAVG----NVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 174 SAILMTLLIPLAWtlkaPMYTDPNAATTKPQPALTFKQILviakNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFN 253
Cdd:COG2807 177 WALLALLALLLWL----PLLRRRPAAAAAAPAAASLRSLW----RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 254 ATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLpLSTWTIYGFGVIMGLLWLSTVPLTNGI 333
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL-APGSLPWLWAVLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 334 VANMFG-VKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWV 392
Cdd:COG2807 328 IGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-396 |
8.67e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 106.88 E-value: 8.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 3 DTRFSKALIYMLMGSAIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAA 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 83 GGALYALGLLLMAVSSTGWLLNLSAGLiLGLALSATsFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLL 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFL-LGLGEAGF-FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 163 QNLGWKGALVVSAILMTLLIPLAwtlkapmytdpnaattkpqpaltfkqilviaknhkpFWFLSLGFFVCGFQVVFIGIH 242
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALLR------------------------------------FWLLALAYFLVYFALYGFLTW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 243 LPGYLID-HGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPH--LLMWLYGLRGLAIIAFLLLPlSTWTIYGFGVIM 319
Cdd:COG2271 203 LPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLP-SPALAIALLFLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1832152327 320 GLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGnYNAIWMFSIALSAFGVWVHFFV 396
Cdd:COG2271 282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLL 357
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
17-396 |
4.12e-24 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 102.49 E-value: 4.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 17 SAIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAV 96
Cdd:cd17314 8 SFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 97 SSTGWLLNLSAGLILGLALSATSFPILLsaVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAI 176
Cdd:cd17314 88 VFNSFPLSYACFVFIGAGTGILYGSAVL--VTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 177 LMTLLIPLAWTLKAPMYTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLidHGFNATT 256
Cdd:cd17314 166 LAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSL--QLDAPSF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 257 STIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMW-LYGLRGLAIIAFLLLPLST-WTIYGFGVIMGLLWLSTVPLTNGIV 334
Cdd:cd17314 244 VTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSiLLTILGLGLCAFLFLLKMTpVGLVLTGSLLGFSYGGLFTVYPATV 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832152327 335 ANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWVHFFV 396
Cdd:cd17314 324 STVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-358 |
3.66e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 3.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 2 SDTRFSKALIYMLMGSAIILALSLGVrhaFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVA 81
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGI---VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 82 AGGALYALGLLLMAVSSTGWLLnLSAGLILGLAlSATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLL 161
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLL-LAARFLQGLG-AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 162 LQNLGWKGALVVSAILMTLLIPLAWTLKAPmytdpnaatTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGI 241
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPE---------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 242 HLPGYLID-HGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPlSTWTIYGFGVIMG 320
Cdd:COG2814 229 YLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLG 307
|
330 340 350
....*....|....*....|....*....|....*...
gi 1832152327 321 LLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGS 358
Cdd:COG2814 308 FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
16-389 |
8.52e-20 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 89.92 E-value: 8.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 16 GSAIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMA 95
Cdd:cd17352 7 ASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 96 VSSTGWLLNLSAGLILGLALsATSFPILLSAVGRaAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSA 175
Cdd:cd17352 87 FATSLWQLYLTYGVLGGLGL-GLIYSPAIVIVGQ-YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 176 ILMTLLIPLAWTLKApmytdpnaattkpqpaltFKQILVIaknhkpFWFLSLGFFVCGFQVVFigIHLPGYLIDHGFNAT 255
Cdd:cd17352 165 GLCLNLCVCGLLLRL------------------LKDPTFV------LLALGVSFAMLGFFVPF--VYLPSYAKSLGIDES 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 256 TSTIFLALVGLFNIVGTYTAGWLGGK--YSKPHLLMWLYGLRGLAIIAFlLLPLSTWTIYGFGVIMGLLWLSTVPLTNGI 333
Cdd:cd17352 219 DAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAF-PLATTYVGLIVFSVLFGFCSGSYSSLTPVI 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1832152327 334 VANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFG 389
Cdd:cd17352 298 LADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLS 353
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
12-396 |
1.71e-19 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 89.21 E-value: 1.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 12 YMLMGSAIILALSLGVRHAFGLYLVPMSHEFGWG----HNVFSLAIAMQnliwGAVQPITGAFADKYGSKIVVAAGGALY 87
Cdd:cd17353 3 WLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSlasvALAFTLTIVFL----AISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 88 ALGLLLMAVSSTGWLLNLSAGLILGLALSATsFPILLSAVGRAaHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGW 167
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIG-YITPVSTAVKW-FPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 168 KGALVVSAILMTLLIP-LAWTLKAP--MYTDPNAATTKPQPALTFKQILVIAKNHKP-FWFLSLGFFVCGFQVVFIGIHL 243
Cdd:cd17353 157 PTTFLILGIIFLIIIViGAFLIRDPpkGWVPPGVDPLANNAENSPRDYTPREMLRTPtFWLLWLMFFLNATAGLMLIGQA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 244 PGYLID-HGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVIMGLL 322
Cdd:cd17353 237 KPIGQEfAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFC 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1832152327 323 WLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLnHDLTGNYNAIWMFSIALSAFGVWVHFFV 396
Cdd:cd17353 317 YGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-361 |
3.27e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.16 E-value: 3.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 19 IILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSS 98
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 99 TGWLLnLSAGLILGLALSATsFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILM 178
Cdd:pfam07690 84 SLWLL-LVLRVLQGLGAGAL-FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 179 TLLIPLAWTLKAPMYTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFigiHLPGYLIDHGFNATTST 258
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT---YLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 259 IFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPL--STWTIYGFGVIMGLLWLSTVPLTNGIVAN 336
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*
gi 1832152327 337 MFGVKYLTMLSGIVFFTHQVGSFLG 361
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
50-396 |
3.02e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.62 E-value: 3.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 50 SLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLnLSAGLILGLAlSATSFPILLSAVGR 129
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL-LLARFLQGLA-SAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 130 AAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKAPmytDPNAATTKPQPALTF 209
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE---PRPPPNKRAVSAARL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 210 KQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDH-GFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLL 288
Cdd:cd17325 189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 289 MWLYGLRGLAIIAFLLLPlSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLN 368
Cdd:cd17325 269 LIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
|
330 340
....*....|....*....|....*...
gi 1832152327 369 HDLTGNYNAIWMFSIALSAFGVWVHFFV 396
Cdd:cd17325 348 YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
12-377 |
1.08e-14 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 75.12 E-value: 1.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 12 YMLMGSA-IILALSLGVRHAFGLYLVPMSHEF-------GWghnVFSLAIAMQNLiwgaVQPITGAFADKYGSKIVVAAG 83
Cdd:cd17423 2 WVVVLAAfLQNALVFGVLRSFGVFFVEFVEYFeesaqrvSW---ITSIGLAVQQL----ASPVGSALSTRYGARPVVMLG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 84 GALYALGLLLMAVSSTGWLLNLSAGLILGLALsATSFPILLSAVGRaAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQ 163
Cdd:cd17423 75 GLLSSLGFLLASFATSLLHLYLCIGLLSGLGW-ALVFAPTMATVSR-YFSRRRSLATGLALTGVGLSSFALSPLFQLLLD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 164 NLGWKGAL-VVSAILMTLLIPLAWTLKAPMYTDPNAATTKPQPALTFKQIlviakNHKPF--WFLSLGFFVCGFQVVFig 240
Cdd:cd17423 153 TYAWRGALlLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAFGLSLL-----THRAFlrYALATTLINTGYFIPY-- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 241 IHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLG--GKYSKPHLLMWLYGLRGLAIIAFLLLPLSTwTIYGFGVI 318
Cdd:cd17423 226 VHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLAdlGPLRLLHLLVLWTALTGLSLLLLPLAKVYG-SLLALAVA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1832152327 319 MGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNA 377
Cdd:cd17423 305 YGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTA 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-392 |
1.56e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.39 E-value: 1.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 18 AIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVS 97
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 98 STGWLLnLSAGLILGLAlSATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNL--GWKGALVVSA 175
Cdd:cd06174 82 PSFWLL-LLGRFLLGLG-SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 176 ILMTLLIPLAWTLKAPMYTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNAT 255
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 256 TSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVA 335
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1832152327 336 NMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWV 392
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
35-394 |
2.55e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.57 E-value: 2.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 35 LVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLnLSAGLILGLA 114
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 115 LSATsFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKapmyt 194
Cdd:cd17324 101 HGGF-WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 195 dPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVV---FIGIHLPGyliDHGFNATTSTIFLALVGLFNIVG 271
Cdd:cd17324 175 -PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFAlytYLAPFLTD---VPGFSSSAIIGLLLLFGVAGVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 272 TYTAGWLGGKYSKPHLLMWLyGLRGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGvKYLTMLSGIVF 351
Cdd:cd17324 251 SPLAGRLADRGGRRALLIAL-LLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1832152327 352 FTHQVGSFLGGWLGGLNHDLTGnYNAIWMFSIALSAFGVWVHF 394
Cdd:cd17324 329 AAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
133-367 |
5.46e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 5.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 133 PSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKG-------ALVVSAILMTLLIPLAWTLKAPMYTdpnaattkPQP 205
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgyrltALIFAVLGLLAFLLTFFGTKERPVP--------EEE 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 206 ALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDH-GFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSK 284
Cdd:COG2211 214 KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 285 PHLLMWLYGLRGLA-IIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVANM-------FGVKYLTMLSGIVFFTHQV 356
Cdd:COG2211 294 KKAFIIGLLLAALGlLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKL 373
|
250
....*....|.
gi 1832152327 357 GSFLGGWLGGL 367
Cdd:COG2211 374 GQALAGALAGL 384
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
14-391 |
2.51e-10 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 61.68 E-value: 2.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 14 LMGSAIILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLL 93
Cdd:TIGR00892 21 LGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMIL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 94 MAVSSTGWLLNLSAGLILGLALsATSFPILLSAVGRAAHpSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGA-LV 172
Cdd:TIGR00892 101 ASFSSNVIELYLTAGFITGLGL-AFNFQPSLTMLGKYFY-RRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSfLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 173 VSAILM------TLLIPLAwtlkAPMYTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFF--------VCGFQVVF 238
Cdd:TIGR00892 179 LGGLLLhccvcgALMRPVG----PSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFthrgflvyLSGNVIMF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 239 IGIHLP-----GYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGG-KYSKPHlLMWLYGLRGLAI-IAFLLLPLST-- 309
Cdd:TIGR00892 255 LGFFAPiiflvPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGlKWIRPH-VQYLFSFALLFNgLTHLLCALAGdy 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 310 WTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAI-WMFSIALSAF 388
Cdd:TIGR00892 334 TGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIfYASGSIVVSA 413
|
...
gi 1832152327 389 GVW 391
Cdd:TIGR00892 414 GLF 416
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
50-351 |
1.14e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 59.49 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 50 SLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAGLIlglALSATSFPILLSAVGR 129
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA---GIGSAAFHPEGARLAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 130 AAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKAPMYTDPNAATTKPQPALTF 209
Cdd:cd17478 111 QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 210 KQILviaknhKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLM 289
Cdd:cd17478 191 KGVW------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVII 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832152327 290 WLYGLRGLAIIAFLLLPLstWTIYGFGVIMGLLWLSTVPLTNGIVANMFGvKYLTMLSGIVF 351
Cdd:cd17478 265 ASLLLAAPFLLLFLLTPG--IWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMM 323
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
66-387 |
2.09e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.79 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 66 ITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLlnLSAGLILGLALSATSFPILLSAVGRAAHPSKRSLAMGIASA 145
Cdd:cd17475 50 PAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV--LLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQT 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 146 AGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTlkapMYTDPNAATTKPQPALTFKQILVIAKNHKPFWFL 225
Cdd:cd17475 128 GVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWL----FYREPPAASAATESASTLLRSLKEVLRNRDVWLI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 226 SL-GFFVCGFQVVFIgIHLPGYLIDH-GFNATTSTIFLALVGLFNIVGTYTAGWL-----GGKYSKPhlLMWLYGLRGLA 298
Cdd:cd17475 204 AIaGALLVAPQFALL-TFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVsdrvfGGRRRPV--LVITAAIAAAA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 299 IIAFLLLPLST--WTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYN 376
Cdd:cd17475 281 LLVLSLLSPGTplWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYA 360
|
330
....*....|.
gi 1832152327 377 AIWMFSIALSA 387
Cdd:cd17475 361 PAWLALALLLV 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
125-392 |
1.81e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.64 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 125 SAVGRAAHPSKRSLAMGIASAAGSFGqFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKAPMytdpnaaTTKPQ 204
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLG-FALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAP-------EIEEA 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 205 PALTFKQILVIAknhkpfWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSK 284
Cdd:cd17477 179 ESISLRRLLRIA------PLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 285 PHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWL 364
Cdd:cd17477 253 RRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLL 332
|
250 260
....*....|....*....|....*...
gi 1832152327 365 GGLNHDLTGNYNAIWMFSIALSAFGVWV 392
Cdd:cd17477 333 AGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-385 |
2.21e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.63 E-value: 2.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 31 FGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAGLI 110
Cdd:COG0738 27 WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 111 -LGLALSATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMlptTLLLLQNLG--WKGALVVSAILMTLLIPLAWT 187
Cdd:COG0738 107 gLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLG---GLLILLGLSlsWHLPYLILAVLLLLLALLFLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 188 LKAPMYTDPNAATTKPQPALTFkqilviAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLID-HGFNATTSTIFLALVGL 266
Cdd:COG0738 184 SKLPEIEEEEEEAAGSAASLKS------LLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 267 FNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFgVIMGLLWLSTVPLTNGIVANMFGVKYLTML 346
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAV 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 1832152327 347 SGIVFFThQVGSFLGGWLGGLNHDLTGNYNAIWMFSIAL 385
Cdd:COG0738 337 SAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFLVPLVCY 374
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
68-389 |
3.94e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.51 E-value: 3.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 68 GAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLsAGLILGLALSAtSFPILLSAVGRAAHPSKRSLAMGIASAAG 147
Cdd:cd17365 55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGA-AMPNAITLVSEYAPARRRSLAVTLMFCGY 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 148 SFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKApmytdpnaattkpqpaltfkqilviaknhkpfwfLSL 227
Cdd:cd17365 133 PLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTLL----------------------------------LWV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 228 GFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPL 307
Cdd:cd17365 179 TFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 308 STWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSA 387
Cdd:cd17365 259 SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAA 338
|
..
gi 1832152327 388 FG 389
Cdd:cd17365 339 LG 340
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
28-396 |
4.24e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.50 E-value: 4.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 28 RHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVsSTGWLLNLSA 107
Cdd:cd17319 19 RVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-ATSLTSLYVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 108 GLILGLAlSATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWt 187
Cdd:cd17319 98 RFLLGVA-EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 188 lkapmytdpnaattkpqpaltfkqilviaKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLID-HGFNATTSTIFLALVGL 266
Cdd:cd17319 176 -----------------------------FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 267 FNIVGTYTAGWLGGKYS--KPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLT 344
Cdd:cd17319 227 AGAIGMILGGRLSDRLLrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAA 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1832152327 345 MLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWVHFFV 396
Cdd:cd17319 307 TAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-395 |
5.40e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.08 E-value: 5.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 49 FSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAGLILGLALSATS---FPILLS 125
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaffGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 126 AVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKAPmyTDPNAATTKPQP 205
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRP--PPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 206 ALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDH-GFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSK 284
Cdd:cd06173 194 LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRR 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 285 PHLLMWLYGLRGLAIIAFLLLPlSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWL 364
Cdd:cd06173 274 GRLLLIGALLLGLALLVLGLSP-SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
330 340 350
....*....|....*....|....*....|.
gi 1832152327 365 GGLNHDLTGNYNAIWMFSIALSAFGVWVHFF 395
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-376 |
8.64e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.70 E-value: 8.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 34 YLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAGLIlGL 113
Cdd:cd17328 21 VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALV-GI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 114 ALsATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFI-MLPTTLLLLQNLGWKGALVVSAILMTLLIPLAW-TLKAP 191
Cdd:cd17328 100 GE-ASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLgYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLlFVREP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 192 MYTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGF----FVCGFQVVFIGIHL-PGYLIDHGFNATTSTIFLALVGL 266
Cdd:cd17328 179 PRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFtavsFVTGALAFWAPTFFlRAFGVGDLSSADVGLIFGAITCI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 267 FNIVGTYTAG----WLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLS------TWTIYGFGVIMGLLWLstvPLTNGIVAN 336
Cdd:cd17328 259 AGVLGVLLGGiladRLRRKTPRADPLVCAVGLLAAAPFLFLALVLAlsnlllAWVLLFLGEFLLSLNW---APVFAILLY 335
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1832152327 337 MFGVKYLTMLSGI-VFFTHQVGSFLGGWLGGLNHDLTGNYN 376
Cdd:cd17328 336 VVIPTRRSTASAIqILLSHLLGDAGSPYLIGLISDLLRQNK 376
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
103-382 |
1.01e-06 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 50.19 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 103 LNLSAGLILGLALSATSFPILlSAVGRAAHpSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLI 182
Cdd:cd17424 94 LYLTLGVLTGLGFALCYSPAI-AMVGKYFH-KRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLC 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 183 PLAWTLKAPMYTDpnaattkpqpaltfkqilviaknhkpFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLA 262
Cdd:cd17424 172 VCGALMRFLLMPD--------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMS 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 263 LVGLFNIVGTYTAGWLGG----KYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIyGFGVIMGLLWLSTVPLTNGIVANMF 338
Cdd:cd17424 226 ILGVIDIIGNITFGWLTDrrclKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLV-PFSFTFGYFDGAYVALIPVVTSDVV 304
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1832152327 339 GVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFS 382
Cdd:cd17424 305 GTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLS 348
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
65-388 |
1.14e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 65 PITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLnLSAGLILGLALSATsFPILLSAVGRAAHPSKRSLAMGIAS 144
Cdd:cd17473 53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-LASRALLGIGVAGI-MTLATALIGDYFEGEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 145 AAGSFGQFIMLPTTLLLLQnLGWKGALVVSAILMTLLIPLAWTLKAPMYTDPNAATTKPQPALTFKQILVIAknhkpfWF 224
Cdd:cd17473 131 AAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLP------IY 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 225 LSLGFFVCGFQVVFIgiHLPGYLIDHG-FNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYglrGLAIIAFL 303
Cdd:cd17473 204 FLAFLAMLLFYVIPI--QLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF---ALMALGFL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 304 LLPLST--WTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIV----FFTHQVGSFLGGWLGGLNHDLTGNYNA 377
Cdd:cd17473 279 LLALASglWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVtsafFLGQFLSPLVLGPLVNLTGGLSGAFLI 358
|
330
....*....|.
gi 1832152327 378 IWMFSIALSAF 388
Cdd:cd17473 359 LGVLALVLAIV 369
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
66-394 |
5.29e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.02 E-value: 5.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 66 ITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAGLILGLALsaTSFPILLSAVGRAAHPSKRSLAMGIASA 145
Cdd:cd17341 53 PYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG--ANFASGQPWASFWFPKEKIGGAAGGIAG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 146 AGSFG----QFIMLP---TTLLLLQNLGWKGALVVSAILMTLLIPLAWTLkapmytdPNAATTKPQPALTF-KQILVIAK 217
Cdd:cd17341 131 AGNMGvavsQLLAPLiagAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLF-------GDDLPTGKASALEFlKVQLAVLK 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 218 NHKPfWFLSLGFFVCGFQVVFIGIHLPGYLIDH-GFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRG 296
Cdd:cd17341 204 NYRT-WILSLLYGVTFGSFVGFSNVLPTYFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMT 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 297 L-AIIAFLLLPLSTWTIYGFGVIMGLLWLSTvPLTNGIVANMFGV---KYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLT 372
Cdd:cd17341 283 IgAALLSLSLPTSGTNLVLFLALFVALGLGA-GAGNGSVFRMVPFifrRELGAVTGLVGAIGGLGGFFLPLLFGSSALMT 361
|
330 340
....*....|....*....|...
gi 1832152327 373 GNYN-AIWMFSIALSAFGVWVHF 394
Cdd:cd17341 362 GSGVgAFSLFGVLAVACTLLVWL 384
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-189 |
8.96e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 8.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 4 TRFSKALIYMLMGSAIILALSLGVRHAF-GLYlvpMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAA 82
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPFlPLY---AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 83 GGALYALGLLLMAVSSTGWLLNLSAgLILGLALsATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLL 162
Cdd:cd17325 271 GLLLSAVALLLLPLATSFWLLLLLL-ALLGLGL-GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
170 180
....*....|....*....|....*..
gi 1832152327 163 QNLGWKGALVVSAILMTLLIPLAWTLK 189
Cdd:cd17325 349 DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
220-398 |
1.74e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 220 KPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAI 299
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 300 IAFLLLPlSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIW 379
Cdd:COG2814 90 LLCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170
....*....|....*....
gi 1832152327 380 MFSIALSAFGVWVHFFVNE 398
Cdd:COG2814 169 VNAVLALLALLLLLRLLPE 187
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-193 |
2.59e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 9 ALIYMLMGSAIILALSLGVRHAFGLYLVP-MSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALY 87
Cdd:COG2271 177 LALLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 88 ALGLLLMAVSSTGWLLNLSAGLILGLALSATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGW 167
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....*.
gi 1832152327 168 KGALVVSAILMTLLIPLAWTLKAPMY 193
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-389 |
6.42e-05 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 44.74 E-value: 6.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 19 IILALSLGVRHAFGLYLVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSS 98
Cdd:cd17422 10 FVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFAS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 99 TGWLLNLSAGLILGLALSATSFP---ILLSAVGRaahpsKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSA 175
Cdd:cd17422 90 SIVEMYLTIGIISGLGYCFTFLPtvtILSQYFKK-----RRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 176 ILMTLLIPLAWTLKapmytdpnaatTKPQPALTFKQILVIaknhkpfwFLSLGFFVCGFQVVFIGIHLpgylidhGFNAT 255
Cdd:cd17422 165 ALQLNIVVCGALLR-----------VLKEPGFICYALFGL--------FATLGFFAPQLYIIPLSLSL-------GIDQD 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 256 TSTIFLALVGLFNIVGTYTAGWLGGK--YSKPHLLMWLYGLRGLAIIAFlllPLST--WTIYGFGVIMGLLWLSTVPLTN 331
Cdd:cd17422 219 WAAYMLSAMAIAELFGRISAGWVLNKcpIRKIYIELICVILLCVVLLLF---PFAYgfWSLLVCSIFYGFMFGTVAGTHI 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 332 GIVA--NMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFG 389
Cdd:cd17422 296 PLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALG 355
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
36-394 |
7.51e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 7.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 36 VPMSHEFGWGHNVfsLAIAMQNLIWGAV--QPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAGLILGL 113
Cdd:cd17380 23 VPMAKEFGWSKTD--QGLVLSSFFWGYAltQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 114 ALSATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILmTLLIPLAWTLKAPmy 193
Cdd:cd17380 101 LGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLL-GLLWALVWLIYLP-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 194 tdpnaattkpqpaltfkqilviaknhkPFWFLSLGFFvCGFQVVFIGIH-LPGYLIDHGFNATTSTIFLALVGLFNIVGT 272
Cdd:cd17380 178 ---------------------------PVWAIIVAHF-CMNWGFYILLSwLPTYFHEVLVPLAKGWVFNVVPWLVMFPSS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 273 YTAGWLGG-----KYSKPHLLMWLYGLrGLAIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTN-GIVANM--FGVKYLT 344
Cdd:cd17380 230 NVAGWLADhlisrGWTVTSVRKLMQSI-GFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSsGVLVNHqdIAPNYAG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1832152327 345 MLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFG--VWVHF 394
Cdd:cd17380 309 IVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGavVFLLF 360
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
103-324 |
2.49e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 103 LNLSAGLILGLALSATSFPILLSAVG-RAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLL 181
Cdd:cd17485 92 LLAFLGLLFLLNLFSATQDIATDGLAvELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 182 IPLAWTLKAPmyTDPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIhLPGYLIDHGFNATT----S 257
Cdd:cd17485 172 LLPVLFLREL--ELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAM-LPPFLVDRGFSLSQigllS 248
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1832152327 258 TIFLALVGlfnIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGFGVI--MGLLWL 324
Cdd:cd17485 249 GVGGSLVS---IAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLasLALLHL 314
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
225-398 |
4.30e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 225 LSLGFFVCGFQVVFIGIHLPGYLI-DHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFL 303
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 304 LLPlSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSI 383
Cdd:pfam07690 81 FAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|....*
gi 1832152327 384 ALSAFGVWVHFFVNE 398
Cdd:pfam07690 160 LSLLAAVLLLLPRPP 174
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
38-394 |
7.44e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 38 MSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLnLSAGLILGLAlSA 117
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIG-AA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 118 TSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAwtlkapmytdpn 197
Cdd:cd17321 100 AIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 198 aattkpqpaltfkqilviaknhKPFWFLSLGFFVCGFQVVFIGIHLPGYLID-HGFNATTSTIFLALVGLFNIVGTYTAG 276
Cdd:cd17321 168 ----------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 277 WLGGKYSKPHLLMW--LYGLRGLAIIAFLLLPLSTWTIYGFGVIMGL-LWLSTVPLTNGIVANMfGVKYLTMLSGIVFFT 353
Cdd:cd17321 226 RLADRFGPRLVLVAglLLTAVGLLLLALLGADSSVWLLLPGLVLLGLgLGLFATPLTNAALSSV-PKEKAGAASGILNTA 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1832152327 354 HQVGS-----FLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWVHF 394
Cdd:cd17321 305 RQLGGalgvaLLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFHL 350
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
49-400 |
9.25e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.29 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 49 FSLAIAMqnLIWGAVQPITGAFADKYGSK--IVVAAGGALYALGLLLMAVSSTGWLLNLsAGLILGLALSATSFPILLSA 126
Cdd:COG2270 56 YALAIAG--LLVALLAPVLGAIADRSGRKkpFLAFFTLLGVLATAALFFVAPGGLWLGL-LLFVLANIGFEGSLVFYNAF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 127 VGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKG----------ALVVSAILMTLL-IPLAWTLKapmytD 195
Cdd:COG2270 133 LPDIATPEEIGRVSGLGWALGYLGGVLLLLINLALFLKPEAFGlpdageavriSFLLTALWWLLFaLPLFLFLP-----E 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 196 PNAATTKPQPALTF------KQILVIAKNHKPFWFLSLGFFV--CGFQVVFI--GIHLPGYLidhGFNATTSTIFLALVG 265
Cdd:COG2270 208 RPRPGPAPPRGAVRagfrelRRTLRELRRYRDLLRFLLAYFFyrDGVQTVIAfaGIYAAGVL---GFSTTELIVFGLLVQ 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 266 LFNIVGTYTAGWLGGKY-SKPHLLMWLYGLRGLAIIAFLLLplSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLT 344
Cdd:COG2270 285 IVAALGALLFGRLDDRIgPKRVILVSLVIWIVVCLAAYFLT--TALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREA 362
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1832152327 345 MLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIALSAFGVWVHFFVNEQA 400
Cdd:COG2270 363 EFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVPR 418
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
222-396 |
9.38e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.01 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 222 FWFLSLGFFVCGFQVVFIGIHLPGYLID-HGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLM---WLYGLRGL 297
Cdd:cd17502 169 ILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIvigTILMSVGA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 298 AIIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGglnhdltgnynA 377
Cdd:cd17502 249 GLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT-----------D 317
|
170
....*....|....*....
gi 1832152327 378 IWMFSIALSAFGVWVHFFV 396
Cdd:cd17502 318 VFLVALALAALAFLLSLFL 336
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
122-388 |
1.22e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 40.64 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 122 ILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNL--GWKGALVVSAILmTLLIPLAWtLKAPMYTDPNAA 199
Cdd:cd17339 105 VLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQALggGWRGALAIWALP-ALLALLIW-LPQLRRRKRAAA 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 200 TTKPQPaltfkqilviaknHKPFWFLSLGFFVcgfqVVFIGIH----------LPGYLIDHGFNATTSTIFLALVGLFNI 269
Cdd:cd17339 183 AAAPLT-------------KISVWRSPLAWQV----TLFMGLQsllfytlmawLPTILIDAGLSAATAGWLLSLFQLVGI 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 270 VGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLsTWTIYGFGVIMGLLWLSTVPLTNgivaNMFGVKYLT----- 344
Cdd:cd17339 246 PASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAP-TALALLWAVLLGLGGGAAFSLAL----TLISLRSSDpaeaa 320
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1832152327 345 MLSGivfFTHQVG---SFLGGWLGGLNHDLTGNYNAIWMFSIALSAF 388
Cdd:cd17339 321 ALSG---MAQSVGyllAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-383 |
1.53e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 38 MSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLSAgLILGLAlSA 117
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL-VLTGFG-GG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 118 TSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFI-MLPTTLLLLQNLGWkgALVVSAILMTLLIPLAWTLKapmytDP 196
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIgPLLGGLLLLYSFRL--LFLAAAVLFLLAALVLLFLL-----PE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 197 NAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLID-HGFNATTSTIFLALVGLFNIVGTYTA 275
Cdd:cd17329 177 TRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEiLGLGESLLGLLLALNALLIVLLQFPV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 276 GWLGGKYSKPHLLMWLYGLRGLAiIAFLLLPLSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQ 355
Cdd:cd17329 257 ARLVERFRLRKILMIGILLFAIG-FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWG 335
|
330 340
....*....|....*....|....*...
gi 1832152327 356 VGSFLGGWLGGLNHDLTGNYNAIWMFSI 383
Cdd:cd17329 336 LGRAIGPLVGGLLLDLLGPGLPWLILAA 363
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
166-385 |
1.81e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 166 GWKGALVVSAILMTLLIPLawtlkapMYTDPNAATTKPQPALTFKQILviaknhkPFWFLSLGFFVCGFQVVFIGIHLPG 245
Cdd:cd06180 156 GWLALALLSAVLLLLSFLL-------LRRGPSAPTEASAAESAPGLNR-------PLWRLALAYGLFGFGYIITATFLPL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 246 YLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPLSTWTIYGfGVIMGLLWLS 325
Cdd:cd06180 222 IARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLS-AVLFGGTFMA 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 326 TVPLTNGIvANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGNYNAIWMFSIAL 385
Cdd:cd06180 301 ITALVMAL-ARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAA 359
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-390 |
2.31e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 20 ILALSLGVRHAFGLYLV---PMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAV 96
Cdd:cd17489 1 ILLANFFFFLSFYLLLPvlpLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 97 SSTGWLLnLSAGLILGLALSATSFPILLSAVGRAAhPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAI 176
Cdd:cd17489 81 ATSVALL-LVLRLIHGIGWGAFTTAAATLVADIIP-PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 177 LMTLLIPLAWTLKAPMytdPNAATTKPQPALTFKQILViaknhKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFnaTT 256
Cdd:cd17489 159 LALLALLLVFLVKDPP---PVAAEEAEAGTRAFRRLVE-----KKVLPPALILFLASIAYGAISTFLPLYAAERGI--SN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 257 STIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIAFLLLPlSTWTIYGFGVIMGLLWLSTVPLTNGIVAN 336
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG-SPWMLLLAAVLYGLGFGLLFPALQALAVD 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1832152327 337 MFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLNHDLTGnYNAIWMFSIALSAFGV 390
Cdd:cd17489 308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLAL 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
222-390 |
2.35e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 222 FWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYGLRGLAIIA 301
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 302 FLLLP----LSTWTIYGFGVIMGLLWLSTVPLTNGIVANMFGVKYLTMLSGIVFFTHQVGSFLGGWLGGLnhdLTGNYNA 377
Cdd:cd06173 81 LALLAllgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGL---LVALLGP 157
|
170
....*....|...
gi 1832152327 378 IWMFSIALSAFGV 390
Cdd:cd06173 158 GGAFAINALSFLL 170
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
35-280 |
5.82e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 35 LVPMSHEFGWGHNVFSLAIAMQNLIWGAVQPITGAFADKYGSKIVVAAGGALYALGLLLMAVSSTGWLLNLsAGLILGLA 114
Cdd:COG0477 37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA-ARALQGIG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 115 LsATSFPILLSAVGRAAHPSKRSLAMGIASAAGSFGQFIMLPTTLLLLQNLGWKGALVVSAILMTLLIPLAWTLKAPMYT 194
Cdd:COG0477 116 A-GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 195 DPNAATTKPQPALTFKQILVIAKNHKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYT 274
Cdd:COG0477 195 LLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLAL 274
|
....*.
gi 1832152327 275 AGWLGG 280
Cdd:COG0477 275 LLALLL 280
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
136-321 |
8.84e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.06 E-value: 8.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 136 RSLAMGIASAAGSFGQFIM-LPTTLLLLQNLGWKGALVVSAILMTLLIPL-AWTLKAPMYTDPNAATTKPQPALTFKQIL 213
Cdd:pfam13347 139 RSFFSVGGGLLAAALAFPLvLILGGTGLERKGYRIFALIGAVLMLLGVIItAAGTKERVSMRSKEDTGQKEAGSLLDMLK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832152327 214 VIAKNhKPFWFLSLGFFVCGFQVVFIGIHLPGYLIDHGFNATTSTIFLALVGLFNIVGTYTAGWLGGKYSKPHLLMWLYG 293
Cdd:pfam13347 219 EVFRN-RAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGAL 297
|
170 180
....*....|....*....|....*....
gi 1832152327 294 LRG-LAIIAFLLLPLSTWTIYGFGVIMGL 321
Cdd:pfam13347 298 ITIaGFALALLLGPNNTLLFLVLYIIIGF 326
|
|
| |
