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Conserved domains on  [gi|1830349217|ref|WP_168163987|]
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HAMP domain-containing sensor histidine kinase [Olsenella sp. HMSC062G07]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
37-332 5.09e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.90  E-value: 5.09e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  37 VVALVALSLALGGAVVAVTSRWADARFLTALLKLPRSLEHAWQLATLVPDPQSNRAALVYDALQAMGASAASDVEAERRA 116
Cdd:COG0642    27 LLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 117 SREYREYVEGWIHEVKAPITAATLAAG--RQGADGP-----DAVRRELARVSRLVDQALWYARVGSVAADYVIRDTRLAD 189
Cdd:COG0642   107 NEAKSRFLANVSHELRTPLTAIRGYLEllLEELDEEqreylETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 190 LCRASCKAEARLLIERGVTPELLVPEKLV-VPTDAKWVGFVLSQVVVNAAKYGA--THLRFSARVTDGpsggrLTELCVA 266
Cdd:COG0642   187 LLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRREGD-----RVRISVE 261

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 267 DDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG0642   262 DTGPGIPPEDLERIFEPFFRTDPSRRGGG-TGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
37-332 5.09e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.90  E-value: 5.09e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  37 VVALVALSLALGGAVVAVTSRWADARFLTALLKLPRSLEHAWQLATLVPDPQSNRAALVYDALQAMGASAASDVEAERRA 116
Cdd:COG0642    27 LLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 117 SREYREYVEGWIHEVKAPITAATLAAG--RQGADGP-----DAVRRELARVSRLVDQALWYARVGSVAADYVIRDTRLAD 189
Cdd:COG0642   107 NEAKSRFLANVSHELRTPLTAIRGYLEllLEELDEEqreylETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 190 LCRASCKAEARLLIERGVTPELLVPEKLV-VPTDAKWVGFVLSQVVVNAAKYGA--THLRFSARVTDGpsggrLTELCVA 266
Cdd:COG0642   187 LLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRREGD-----RVRISVE 261

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 267 DDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG0642   262 DTGPGIPPEDLERIFEPFFRTDPSRRGGG-TGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 221-332 9.04e-39

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 133.56  E-value: 9.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 221 TDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGPSGgrlTELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMG 300
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQG---VVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1830349217 301 LYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16948    78 LYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 221-332 2.21e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.79  E-value: 2.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  221 TDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGPSGGRLTelcVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMG 300
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEIT---VEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLG 77

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1830349217  301 LYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:smart00387  78 LSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 221-332 5.57e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.56  E-value: 5.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 221 TDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGpsgGRLTeLCVADDGRGIPARDLPRIFDRgFTGENGRAGEGsTGMG 300
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG---GELT-LTVEDNGIGIPPEDLPRIFEP-FSTADKRGGGG-TGLG 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1830349217 301 LYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 40-332 6.35e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 72.57  E-value: 6.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  40 LVALSLALGGAVVAVTSRwadarfltALLKLPRsleHAWQLA--TLVPDPQSNRAAL--VYDALQAMgasaasdveaerR 115
Cdd:PRK11100  191 LLGIALLIGAGVVWWLNR--------SIRRLTR---YADAVTegKPVPLPKLGSSELreLAQALESM------------R 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 116 ASREYREYVEGWI----HEVKAPItAATLAAGRQGADGPDA---------VRRELARVSRLVDQALWYARVGSVAADYVI 182
Cdd:PRK11100  248 VKLEGKAYVEQYVqtltHELKSPL-AAIRGAAELLQEDPPPedrarftgnILTQSARLQQLIDRLLELARLEQRQELEVL 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 183 RDTRLADLCRASCKAEARLLIERGVTPELLVPEkLVVPTDAKWVGFVLSQVVVNAakygathLRFSarvtdgPSGGRLT- 261
Cdd:PRK11100  327 EPVALAALLEELVEAREAQAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNA-------IDFS------PEGGTITl 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 262 ---------ELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:PRK11100  393 saevdgeqvALSVEDQGPGIPDYALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
37-332 5.09e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.90  E-value: 5.09e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  37 VVALVALSLALGGAVVAVTSRWADARFLTALLKLPRSLEHAWQLATLVPDPQSNRAALVYDALQAMGASAASDVEAERRA 116
Cdd:COG0642    27 LLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 117 SREYREYVEGWIHEVKAPITAATLAAG--RQGADGP-----DAVRRELARVSRLVDQALWYARVGSVAADYVIRDTRLAD 189
Cdd:COG0642   107 NEAKSRFLANVSHELRTPLTAIRGYLEllLEELDEEqreylETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 190 LCRASCKAEARLLIERGVTPELLVPEKLV-VPTDAKWVGFVLSQVVVNAAKYGA--THLRFSARVTDGpsggrLTELCVA 266
Cdd:COG0642   187 LLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRREGD-----RVRISVE 261

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 267 DDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG0642   262 DTGPGIPPEDLERIFEPFFRTDPSRRGGG-TGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 221-332 9.04e-39

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 133.56  E-value: 9.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 221 TDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGPSGgrlTELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMG 300
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQG---VVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1830349217 301 LYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16948    78 LYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
111-332 1.44e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 129.64  E-value: 1.44e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 111 EAERRASREYREYVEGWIHEVKAPITAATLAAG--RQGADGPDAVRRELA--------RVSRLVDQALWYARVGSVAADY 180
Cdd:COG2205     7 EELEELERLKSEFLANVSHELRTPLTSILGAAEllLDEEDLSPEERRELLeiiresaeRLLRLIEDLLDLSRLESGKLSL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 181 VIRDTRLADLCRASCKAEARLLIERGVTPELLVPEKLV-VPTDAKWVGFVLSQVVVNAAKYG--ATHLRFSARVTDGpsg 257
Cdd:COG2205    87 ELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPlVYADPELLEQVLANLLDNAIKYSppGGTITISARREGD--- 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830349217 258 grLTELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG2205   164 --GVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGG-TGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
38-332 4.96e-31

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 120.81  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  38 VALVALSLALGGAVVAVTSRWADARFLTALLKLPRSLEHAWQLATLVPDPQSNRAALVYDALQAMGASAASDVEAERRAS 117
Cdd:COG5002    83 LLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLE 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 118 REYREYVEGWIHEVKAPITAATLAAG---RQGADGPDAVRR-------ELARVSRLVDQALWYARVGSVAADYVIRDTRL 187
Cdd:COG5002   163 QMRREFVANVSHELRTPLTSIRGYLElllDGAADDPEERREyleiileEAERLSRLVNDLLDLSRLESGELKLEKEPVDL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 188 ADLCRASCKAEARLLIERGVTPELLVPEKLV-VPTDAKWVGFVLSQVVVNAAKYGA--THLRFSARVTDGpsggrLTELC 264
Cdd:COG5002   243 AELLEEVVEELRPLAEEKGIELELDLPEDPLlVLGDPDRLEQVLTNLLDNAIKYTPegGTITVSLREEDD-----QVRIS 317

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1830349217 265 VADDGRGIPARDLPRIFDRGFTGENGRAGE-GSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG5002   318 VRDTGIGIPEEDLPRIFERFYRVDKSRSREtGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 221-332 2.21e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.79  E-value: 2.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  221 TDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGPSGGRLTelcVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMG 300
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEIT---VEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLG 77

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1830349217  301 LYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:smart00387  78 LSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 229-329 1.08e-22

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 91.13  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGATHLRFSARVTDGPSGGRLTelcVADDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARIC 308
Cdd:cd00075     4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLE---VEDNGPGIPEEDLERIFERFYRGDKSREGGG-TGLGLAIVRRIV 79

                          90       100
                  ....*....|....*....|.
gi 1830349217 309 ERMGLILEVASEEGEGTRVLV 329
Cdd:cd00075    80 EAHGGRITVESEPGGGTTFTV 100
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 221-332 5.57e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.56  E-value: 5.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 221 TDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGpsgGRLTeLCVADDGRGIPARDLPRIFDRgFTGENGRAGEGsTGMG 300
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG---GELT-LTVEDNGIGIPPEDLPRIFEP-FSTADKRGGGG-TGLG 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1830349217 301 LYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
81-332 4.13e-17

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 81.43  E-value: 4.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  81 ATLVPDPQSNRAALVYdalqamgasaASDVEAERRASREYREY---------VEGWIHEVKAPITAATLAA---GRQGAD 148
Cdd:COG3852    97 VSPLRDAEGEGGVLLV----------LRDITERKRLERELRRAeklaavgelAAGLAHEIRNPLTGIRGAAqllERELPD 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 149 GPDA-----VRRELARVSRLVDQALWYAR-----VGSVAADYVIRDTRlaDLCRASCKAEARllIERGVTPELlvPEKLV 218
Cdd:COG3852   167 DELReytqlIIEEADRLNNLVDRLLSFSRprppeREPVNLHEVLERVL--ELLRAEAPKNIR--IVRDYDPSL--PEVLG 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 219 VPTDakwvgfvLSQVVVN-------AAKYGAT---HLRFSARVTDGPSGGRLT-ELCVADDGRGIPARDLPRIFDRGFTG 287
Cdd:COG3852   241 DPDQ-------LIQVLLNlvrnaaeAMPEGGTitiRTRVERQVTLGGLRPRLYvRIEVIDNGPGIPEEILDRIFEPFFTT 313

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1830349217 288 -ENGragegsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG3852   314 kEKG------TGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 129-332 6.97e-17

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 81.16  E-value: 6.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 129 HEVKAPITAATLAAGR-------QGADGPDAVRR-------ELARVSRLVDQALWYARVGSVaadyVIRDTRLADLCRAS 194
Cdd:COG5000   210 HEIKNPLTPIQLSAERlrrkladKLEEDREDLERaldtiirQVDRLKRIVDEFLDFARLPEP----QLEPVDLNELLREV 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 195 CKAEARLLIERGVTPEL-LVPEKLVVPTDAKWVGFVLSQVVVNA--AKYGATHLRFSARVTDGpsggrLTELCVADDGRG 271
Cdd:COG5000   286 LALYEPALKEKDIRLELdLDPDLPEVLADRDQLEQVLINLLKNAieAIEEGGEIEVSTRREDG-----RVRIEVSDNGPG 360

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830349217 272 IPARDLPRIFDRGFTG-ENGragegsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG5000   361 IPEEVLERIFEPFFTTkPKG------TGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 129-332 1.14e-15

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 77.90  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 129 HEVKAPITA----ATLAAGRQGADGPDAVRRELARV-------SRLVDQALWYARVGSVAADyvIRDTRLADLCRASCKA 197
Cdd:COG4251   291 HDLREPLRKisgfSQLLEEDYGDKLDEEGREYLERIrdaaermQALIDDLLAYSRVGRQELE--FEPVDLNELLEEVLED 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 198 EARLLIERGVtpELLVPEKLVVPTDAKWVGFVLSQVVVNAAKYGAT----HLRFSARVTDGpsggrLTELCVADDGRGIP 273
Cdd:COG4251   369 LEPRIEERGA--EIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGG-----EWVFSVRDNGIGID 441

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1830349217 274 ARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG4251   442 PEYAEKIFEIFQRLHSRDEYEG-TGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 40-332 6.35e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 72.57  E-value: 6.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  40 LVALSLALGGAVVAVTSRwadarfltALLKLPRsleHAWQLA--TLVPDPQSNRAAL--VYDALQAMgasaasdveaerR 115
Cdd:PRK11100  191 LLGIALLIGAGVVWWLNR--------SIRRLTR---YADAVTegKPVPLPKLGSSELreLAQALESM------------R 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 116 ASREYREYVEGWI----HEVKAPItAATLAAGRQGADGPDA---------VRRELARVSRLVDQALWYARVGSVAADYVI 182
Cdd:PRK11100  248 VKLEGKAYVEQYVqtltHELKSPL-AAIRGAAELLQEDPPPedrarftgnILTQSARLQQLIDRLLELARLEQRQELEVL 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 183 RDTRLADLCRASCKAEARLLIERGVTPELLVPEkLVVPTDAKWVGFVLSQVVVNAakygathLRFSarvtdgPSGGRLT- 261
Cdd:PRK11100  327 EPVALAALLEELVEAREAQAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNA-------IDFS------PEGGTITl 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 262 ---------ELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:PRK11100  393 saevdgeqvALSVEDQGPGIPDYALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 229-332 9.38e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 66.75  E-value: 9.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKY---GATHLRFSARvTDGPSGGRLtELCVADDGRGIPARDLPRIFDRgFT---GENGRAGEGsTGMGLY 302
Cdd:cd16922     4 ILLNLLGNAIKFteeGEVTLRVSLE-EEEEDGVQL-RFSVEDTGIGIPEEQQARLFEP-FSqadSSTTRKYGG-TGLGLA 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1830349217 303 LAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16922    80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-333 2.27e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 65.52  E-value: 2.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKygATHLRFSARVTDGPSGGRLTeLCVADDGRGIPARDLPRIFDRGFTGEngRAGEGsTGMGLYLAARIC 308
Cdd:cd16943     7 VLLNLLVNAAQ--AMEGRGRITIRTWAHVDQVL-IEVEDTGSGIDPEILGRIFDPFFTTK--PVGEG-TGLGLSLSYRII 80

                          90       100
                  ....*....|....*....|....*
gi 1830349217 309 ERMGLILEVASEEGEGTRVLVGFPH 333
Cdd:cd16943    81 QKHGGTIRVASVPGGGTRFTIILPI 105
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 129-332 3.59e-13

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 69.83  E-value: 3.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 129 HEVKAPITAATLAAG------RQGADGPDA------VRRELARVSRLVDQALWYARVGSVAadyvIRDTRLADLCRASCK 196
Cdd:COG4191   151 HEINNPLAAILGNAEllrrrlEDEPDPEELrealerILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 197 AEARLLIERGVTPELLVPEKL-VVPTDAkwvgFVLSQVVVN---------AAKYGAThLRFSARVtdgpsGGRLTELCVA 266
Cdd:COG4191   227 LLRPRLKARGIEVELDLPPDLpPVLGDP----GQLEQVLLNllinaidamEEGEGGR-ITISTRR-----EGDYVVISVR 296

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 267 DDGRGIPARDLPRIFDRGFTgeNGRAGEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG4191   297 DNGPGIPPEVLERIFEPFFT--TKPVGKG-TGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
110-336 3.76e-13

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 70.38  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 110 VEAERRASREYR-----EYVEGWIHEVKAPITAAT--LAAGRQGADGP------DAVRRELARVSRLVDQALWYAR---- 172
Cdd:PRK11360  375 KRLQRRVARQERlaalgELVAGVAHEIRNPLTAIRgyVQIWRQQTSDPpsqeylSVVLREVDRLNKVIDQLLEFSRpres 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 173 -VGSVAADYVIRDTrlADLCRASCKAeARLLIERGVTPELlvPEklvVPTDAKWVGFVLSQVVVNAakYGATHLRFSARV 251
Cdd:PRK11360  455 qWQPVSLNALVEEV--LQLFQTAGVQ-ARVDFETELDNEL--PP---IWADPELLKQVLLNILINA--VQAISARGKIRI 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 252 TDGPSGGRLTELCVADDGRGIPARDLPRIFDRGFTGENgrAGegsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGF 331
Cdd:PRK11360  525 RTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KG---TGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599


                  ....*
gi 1830349217 332 PHDAG 336
Cdd:PRK11360  600 PINPQ 604
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 257-332 6.35e-13

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 69.11  E-value: 6.35e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 257 GGRLTeLCVADDGRGIPARDLPRIFDRGFTGENGrageGSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:COG3290   315 GDELV-IEVEDSGPGIPEELLEKIFERGFSTKLG----EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
126-337 4.70e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 66.73  E-value: 4.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 126 GWIHEVKAPITA----ATLAAGRQGADGPDavrRELA--------RVSRLVDQALWYARvgsvAADYVIRDTRLADLCRA 193
Cdd:PRK10364  243 GVAHEIRNPLSSikglAKYFAERAPAGGEA---HQLAqvmakeadRLNRVVSELLELVK----PTHLALQAVDLNDLINH 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 194 SCKAEARLLIERGVTPELLVPEKL-VVPTDAKWVGFVLSQVVVNAAKYGATHLRFSarVTDGPSGGRLtELCVADDGRGI 272
Cdd:PRK10364  316 SLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVIS--VTASESGAGV-KISVTDSGKGI 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830349217 273 PARDLPRIFDRGFTGENgragEGsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFPHDAGR 337
Cdd:PRK10364  393 AADQLEAIFTPYFTTKA----EG-TGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 452
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
133-332 1.29e-10

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 62.77  E-value: 1.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 133 APITAATLAAGRQGADGPDAVRRELARVSRLVDQALWYARVGsvaaDYVIRDTRLADLCRASCkAEARLLIERGVTPEL- 211
Cdd:PRK13837  472 AEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKG----ERNTKPFDLSELVTEIA-PLLRVSLPPGVELDFd 546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 212 LVPEKLVVPTDAkwvgFVLSQVVVNAAKYGATHLRFSARVTDGPS----------------GGRLTELCVADDGRGIPAR 275
Cdd:PRK13837  547 QDQEPAVVEGNP----AELQQVLMNLCSNAAQAMDGAGRVDISLSraklrapkvlshgvlpPGRYVLLRVSDTGAGIDEA 622

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830349217 276 DLPRIFDRGFTgenGRAgeGSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:PRK13837  623 VLPHIFEPFFT---TRA--GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
envZ PRK09467
osmolarity sensor protein; Provisional
 229-335 3.30e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 61.08  E-value: 3.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGATHLRFSARVTdgpsgGRLTELCVADDGRGIPARDLPRIFdRGFT-GENGRAGEGsTGMGLYLAARI 307
Cdd:PRK09467  335 ALANLVVNAARYGNGWIKVSSGTE-----GKRAWFQVEDDGPGIPPEQLKHLF-QPFTrGDSARGSSG-TGLGLAIVKRI 407

                          90       100
                  ....*....|....*....|....*....
gi 1830349217 308 CERMGLILEVA-SEEGeGTRVLVGFPHDA 335
Cdd:PRK09467  408 VDQHNGKVELGnSEEG-GLSARAWLPLTT 435
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-332 3.39e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 56.30  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGathlRFSARVTDGPSGGRlTELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARIC 308
Cdd:cd16950     4 VLSNLVDNALRYG----GGWVEVSSDGEGNR-TRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSG-TGLGLAIVQRIS 77

                          90       100
                  ....*....|....*....|....
gi 1830349217 309 ERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16950    78 DAHGGSLTLANRAGGGLCARIELP 101
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-332 2.07e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 54.22  E-value: 2.07e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1830349217 265 VADDGRGIPARDLPRIFDRGFTGEngraGEGSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16915    41 VRDTGPGIAPELRDKVFERGVSTK----GQGERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 226-332 2.10e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 54.26  E-value: 2.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 226 VGFVLSQVVVNAAKYgaTHLRFSARVTDGPS-GGRLTELCVADDGRGIPARDLPRIFdRGFTGENGRAGEGSTGMGLYLA 304
Cdd:cd16921     1 LGQVLTNLLGNAIKF--RRPRRPPRIEVGAEdVGEEWTFYVRDNGIGIDPEYAEKVF-GIFQRLHSREEYEGTGVGLAIV 77

                          90       100
                  ....*....|....*....|....*...
gi 1830349217 305 ARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16921    78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 265-337 5.52e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 57.23  E-value: 5.52e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1830349217 265 VADDGRGIPARDLPRIFDRGF-TGENGRagegstGMGLYLAARICERMGLILEVASEEGEGTRVLVGFPHDAGR 337
Cdd:PRK11086  472 VSDDGPGIAPDEIDAIFDKGYsTKGSNR------GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGER 539
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-326 8.54e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 52.46  E-value: 8.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVN--------AAKYGATHLRFSARVtdgpSGGRLtELCVADDGRGIPARDLPRIFDRGFTGENgrAGEGsTGMGL 301
Cdd:cd16976     1 IQQVLMNllqnaldaMGKVENPRIRIAARR----LGGRL-VLVVRDNGPGIAEEHLSRVFDPFFTTKP--VGKG-TGLGL 72

                          90       100
                  ....*....|....*....|....*
gi 1830349217 302 YLAARICERMGLILEVASEEGEGTR 326
Cdd:cd16976    73 SISYGIVEEHGGRLSVANEEGAGAR 97
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-332 8.54e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 52.59  E-value: 8.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVNAAKYGATHLRFSARVTDGPSGGRLTelcVADDGRGIPARDLPRIFDRGFTGENGRAGE-GSTGMGLYLAARIC 308
Cdd:cd16952     5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLS---VEDTGPGIPPEHIPRLTERFYRVDIERCRNtGGTGLGLAIVKHVM 81

                          90       100
                  ....*....|....*....|....
gi 1830349217 309 ERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16952    82 SRHDARLLIASELGKGSRFTCLFP 105
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 195-331 4.33e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 51.48  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 195 CKAEARLLIERGVTPELLVPEKLVVPTDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGPSggrltELCVADDGRGIPA 274
Cdd:cd16954     7 CSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGL-----HLIVDDDGPGVPE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830349217 275 RDLPRIFDRGFTGENGRAGEgstGMGLYLAARICERMGLILEVASEEGEGTRVLVGF 331
Cdd:cd16954    82 SQRSKIFQRGQRLDEQRPGQ---GLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-331 9.15e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 50.10  E-value: 9.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 222 DAKWVGFVLSQVVVNAAKYGATHLRFSARVtdgpSGGRLTELCVADDGRGIPARDLPRIFDRgFTGENGRAGEGStGMGL 301
Cdd:cd16940    10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKL----SADDGAVIRVEDNGPGIDEEELEALFER-FYRSDGQNYGGS-GLGL 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1830349217 302 YLAARICERMGLILEVASEEGEGTRVLVGF 331
Cdd:cd16940    84 SIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PRK13557 PRK13557
histidine kinase; Provisional
 253-339 1.49e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 52.75  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 253 DGPSGGRLTELCVADDGRGIPARDLPRIFDRGFTGEngraGEGS-TGMGLYLAARICERMGLILEVASEEGEGTRVLVGF 331
Cdd:PRK13557  317 HGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTK----EEGKgTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392


                  ....*...
gi 1830349217 332 PHDAGRLA 339
Cdd:PRK13557  393 PASDQAEN 400
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 255-332 2.66e-07

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 51.90  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 255 PSGGRLT-----------ELCVADDGRGIPARDLPRIFDRGF-TGENGragegsTGMGLYLAARICERMGLILEVASEEG 322
Cdd:COG5809   396 PEGGNITietkaedddkvVISVTDEGCGIPEERLKKLGEPFYtTKEKG------TGLGLMVSYKIIEEHGGKITVESEVG 469

                          90
                  ....*....|
gi 1830349217 323 EGTRVLVGFP 332
Cdd:COG5809   470 KGTTFSITLP 479
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
113-331 5.05e-07

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 51.17  E-value: 5.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 113 ERRASREYREYVEGWIHEVKAPI-----TAATLAAGRQgADGPDAVRRELARVSRLVDQALWYARVGSVAADYVI--RDT 185
Cdd:PRK10815  259 ERERYTKYRTTLTDLTHSLKTPLavlqsTLRSLRSGKQ-MSVEQAEPIMLEQISRISQQIGYYLHRASMRSEHNLlsREL 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 186 R-----LADLCRASCKAEARllieRGVTPELLVPEKLVvptdakWVG----F--VLSQVVVNAAKYGATHLRFSARVTDG 254
Cdd:PRK10815  338 HsvaplLDNLTSALNKVYQR----KGVNITLDISPEIT------FVGekndFmeVMGNVLDNACKYCLEFVEISARQTDE 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 255 psggRLTeLCVADDGRGIP--ARDLprIFDRGFTGENGRAGEgstGMGLYLAARICERM-GLILEVASEEGeGTRVLVGF 331
Cdd:PRK10815  408 ----HLH-IVVEDDGPGIPesKREL--IFDRGQRADTLRPGQ---GLGLSVAREITEQYeGKISAGDSPLG-GARMEVIF 476
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 258-332 5.29e-07

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 47.76  E-value: 5.29e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 258 GRLTELCVADDGRGIPARDLPRIFDRGFTGEngraGEGS-TGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16919    45 GNYVCLEVSDTGSGMPAEVLRRAFEPFFTTK----EVGKgTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
88-332 1.38e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 48.85  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217  88 QSNRAALVYDALQAMGASAASDVEAER-RASREyreyvegwIH-EVKAPITAATL---AAGRQGADGPDAVRRELARVSR 162
Cdd:COG4585    28 RARRAERAAELERELAARAEEAREEERrRIARE--------LHdGVGQSLSAIKLqleAARRLLDADPEAAREELEEIRE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 163 LVDQALwyARVGSVAADY---VIRDTRLADLCRASCkaeARLLIERGVTPELLVPEKLVVPTDAKW--VGFVLSQVVVNA 237
Cdd:COG4585   100 LAREAL--AELRRLVRGLrppALDDLGLAAALEELA---ERLLRAAGIRVELDVDGDPDRLPPEVElaLYRIVQEALTNA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 238 AKY-GATHLRFSARVTDGpsggRLTeLCVADDGRGIPARDLPRifdrgftgengragegsTGMGLylaARICERMGLI-- 314
Cdd:COG4585   175 LKHaGATRVTVTLEVDDG----ELT-LTVRDDGVGFDPEAAPG-----------------GGLGL---RGMRERAEALgg 229

                         250
                  ....*....|....*....
gi 1830349217 315 -LEVASEEGEGTRVLVGFP 332
Cdd:COG4585   230 tLTIGSAPGGGTRVRATLP 248
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 255-332 1.71e-06

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 49.73  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 255 PSGGRLT----------ELCVADDGRGIPARDLPRIFDRGFT-GENGragegsTGMGLYLAARICERMGLILEVASEEGE 323
Cdd:COG5805   412 PNGGTITihteeednsvIIRVIDEGIGIPEERLKKLGEPFFTtKEKG------TGLGLMVSYKIIENHNGTIDIDSKVGK 485


                  ....*....
gi 1830349217 324 GTRVLVGFP 332
Cdd:COG5805   486 GTTFTITLP 494
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
236-332 7.56e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 47.32  E-value: 7.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 236 NAAKYGAT------HLRFSARVTdgpsGGRLtELCVADDGRGIPARDLPRIFDRGFTGENGRagegstGMGLYLaarICE 309
Cdd:COG2972   347 NAIEHGIEpkegggTIRISIRKE----GDRL-VITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGLRN---VRE 412

                          90       100
                  ....*....|....*....|....*....
gi 1830349217 310 RMGLI------LEVASEEGEGTRVLVGFP 332
Cdd:COG2972   413 RLKLYygeeygLEIESEPGEGTTVTIRIP 441
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 210-325 8.13e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 44.81  E-value: 8.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 210 ELLVPEKLV---VPTDAkwVGFVLSQVVVNAAKYGAT--HLRFSARVTDgpsggRLTELCVADDGRGIPARDLPRIFDRG 284
Cdd:cd16947     4 EINIPDRPIyanANTEA--LQRILKNLISNAIKYGSDgkFLGMTLREDE-----KHVYIDIWDKGKGISETEKDHVFERL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1830349217 285 FTGENGR--AGEGStGMGLYLAARICERMGLILEVASEEGEGT 325
Cdd:cd16947    77 YTLEDSRnsAKQGN-GLGLTITKRLAESMGGSIYVNSKPYEKT 118
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-315 1.11e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 44.10  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830349217 251 VTDGPSGGRLTeLCVADDGRGIPARDLPRIFDRGFTGENGRAGEGS-TGMGLYLAARICERMGLIL 315
Cdd:cd16953    25 VSAMPTGKMVT-ISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhSGLGLSISRQIIEAHGGIS 89
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-332 1.57e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 43.47  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVNAAKYGATHLRFSARVTdgpsgGRLTELCVADDGRGIPARDLPRIFdRGF--TGENGRAGEGSTGMGLYLAARI 307
Cdd:cd16949     5 LENVLRNALRYSPSKILLDISQD-----GDQWTITITDDGPGVPEDQLEQIF-LPFyrVDSARDRESGGTGLGLAIAERA 78

                          90       100
                  ....*....|....*....|....*
gi 1830349217 308 CERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16949    79 IEQHGGKIKASNRKPGGLRVRIWLP 103
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-323 1.57e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 43.54  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVN-------AAKYGATHLRFSAR----VTDGPSGGRLT-ELCVADDGRGIPARDLPRIFDRGFTGEngragEGST 297
Cdd:cd16918     1 LIQVFLNlvrnaaqALAGSGGEIILRTRtqrqVTLGHPRHRLAlRVSVIDNGPGIPPDLQDTIFYPMVSGR-----ENGT 75

                          90       100
                  ....*....|....*....|....*..
gi 1830349217 298 GMGLYLAARIC-ERMGLIlEVASEEGE 323
Cdd:cd16918    76 GLGLAIAQNIVsQHGGVI-ECDSQPGH 101
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-332 2.16e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 43.22  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVNAakygathLRFSARVTDgpSGGRL----------TELCVADDGRGIPARDLPRIFDRGFTGENGRA-GEGSTG 298
Cdd:cd16946     5 LQQLFVNL-------LENSLRYTD--TGGKLriraaqtpqeVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrASGGSG 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1830349217 299 MGLYLAARICERM-GLILEVASEEGeGTRVLVGFP 332
Cdd:cd16946    76 LGLAICHNIALAHgGTISAEHSPLG-GLRLVLTLP 109
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 229-326 2.74e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 46.09  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKY---GATHLRFSARVTDgpsggrltELC--VADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMGLYL 303
Cdd:PRK11091  402 ILWNLISNAVKFtqqGGVTVRVRYEEGD--------MLTfeVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPATGTGIGL 473

                          90       100
                  ....*....|....*....|....*
gi 1830349217 304 AA--RICERMGLILEVASEEGEGTR 326
Cdd:PRK11091  474 AVskRLAQAMGGDITVTSEEGKGSC 498
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
229-332 5.05e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 45.35  E-value: 5.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGATH-LRFSARVTDGpsggrLTELCVADDGRGIPARDLPRIFDRGFtgengRAGEG----STGMGLYL 303
Cdd:PRK10841  566 VISNLLSNAIKFTDTGcIVLHVRVDGD-----YLSFRVRDTGVGIPAKEVVRLFDPFF-----QVGTGvqrnFQGTGLGL 635

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1830349217 304 AarICERmgLI------LEVASEEGEGTRVLVGFP 332
Cdd:PRK10841  636 A--ICEK--LInmmdgdISVDSEPGMGSQFTIRIP 666
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-332 6.07e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 41.66  E-value: 6.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 228 FVLSQVVVNAAKYGATHLRFSARVT-DGPSGGRLTELCVADDGRGIPARDLPRIfdrgftgenGRAGEGSTGMGLY-LAA 305
Cdd:cd16924     4 FTLQPLVENAIQHGLSPLTDKGVVTiSALKEDNHVMIEVEDNGRGIDPKVLNIL---------GKKPKEGNGIGLYnVHQ 74

                          90       100
                  ....*....|....*....|....*....
gi 1830349217 306 RICERMG--LILEVASEEGEGTRVLVGFP 332
Cdd:cd16924    75 RLILLFGedYGIHIASEPDKGTRITFTIP 103
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-331 7.12e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 41.68  E-value: 7.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGATHLRFSARVTDGPsggRLTELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMGLYLAARIC 308
Cdd:cd16975     8 ALINIISNACQYAPEGGTVSISIYDEE---EYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLV 84

                          90       100
                  ....*....|....*....|...
gi 1830349217 309 ERMGLILEVASEEGEGTRVLVGF 331
Cdd:cd16975    85 EKHGGSLIIENSQKGGAEVTVKI 107
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
186-327 8.47e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 41.82  E-value: 8.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 186 RLADLCRASCKAeARLLIERGVTPELLvpEKLVVptdakwvgfVLSQVVVNAAKYG-----ATHLRFSARVTDGpsggRL 260
Cdd:COG2172     7 DLEDLGLARRAV-RALLRELGLDEDDA--DDLVL---------AVSEAVTNAVRHAyggdpDGPVEVELELDPD----GL 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1830349217 261 tELCVADDGRGIPARDLPRIFDRGFTGengragegstGMGLYLAARICERMglilEVASEEGeGTRV 327
Cdd:COG2172    71 -EIEVRDEGPGFDPEDLPDPYSTLAEG----------GRGLFLIRRLMDEV----EYESDPG-GTTV 121
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
129-332 8.81e-05

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 43.99  E-value: 8.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 129 HEVKAPIT------AATLAAGRQGADGPDAVR---RELARVSRLVDQALWYARVGSvaaDYVIRDTRLADLCRASCKA-- 197
Cdd:PRK09835  271 HEIRTPITnlitqtEIALSQSRSQKELEDVLYsnlEELTRMAKMVSDMLFLAQADN---NQLIPEKKMLDLADEVGKVfd 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 198 --EArLLIERGVTPELlVPEKLVVPTDAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGpsgGRLTELCVADDGRGIPAR 275
Cdd:PRK09835  348 ffEA-WAEERGVELRF-VGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEV---DHQVQLVVENPGTPIAPE 422

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1830349217 276 DLPRIFDRGFTGENGRA--GEGStGMGLYLAARICERMGLILEVASeEGEGTRVLVGFP 332
Cdd:PRK09835  423 HLPRLFDRFYRVDPSRQrkGEGS-GIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-332 1.93e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 40.07  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVNAAKYGATHLRFSAR------VTDGPSGGRLTELCVADDGRGIPARDLPRIFDRGFTGENgragEGsTGMGLYL 303
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGCerreltIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS----EG-LGMGLSI 75

                          90       100
                  ....*....|....*....|....*....
gi 1830349217 304 AARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16920    76 CRSIIEAHGGRLSVESPAGGGATFQFTLP 104
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
230-326 2.04e-04

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 43.08  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 230 LSQVVVNAAKY--GATHLRFSARVTdgPSGGrltELCVADDGRGIPARDLPRIFDRGFTGENGRAGE-GSTGMGLYLAAR 306
Cdd:PRK11006  322 ISNLVYNAVNHtpEGTHITVRWQRV--PQGA---EFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQtGGSGLGLAIVKH 396

                          90       100
                  ....*....|....*....|
gi 1830349217 307 ICERMGLILEVASEEGEGTR 326
Cdd:PRK11006  397 ALSHHDSRLEIESEVGKGTR 416
PRK10604 PRK10604
sensor protein RstB; Provisional
 147-332 2.55e-04

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 42.67  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 147 ADGPDAVRRELARVSRLVDQALWYARVGSVAADYVIRDTRLADLcrasckAEARLLIERGVTPE-----LLVPEKLVVPT 221
Cdd:PRK10604  242 AAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAW------LSTHLADIQAVTPEktvrlDTPHQGDYGAL 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 222 DAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGpsggrLTELCVADDGRGIPARDLPRIFDRgFT---GENGRAgEGSTG 298
Cdd:PRK10604  316 DMRLMERVLDNLLNNALRYAHSRVRVSLLLDGN-----QACLIVEDDGPGIPPEERERVFEP-FVrldPSRDRA-TGGCG 388

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1830349217 299 MGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:PRK10604  389 LGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-332 6.07e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 39.06  E-value: 6.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 222 DAKWVGFVLSQVVVNAAK------YGATHLRFsaRVTDGpSGGRLTeLCVADDGRGIPARDLPRIFDRGFTGEngragEG 295
Cdd:cd16944     1 DTTQISQVLTNILKNAAEaiegrpSDVGEVRI--RVEAD-QDGRIV-LIVCDNGKGFPREMRHRATEPYVTTR-----PK 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1830349217 296 STGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16944    72 GTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
PRK15347 PRK15347
two component system sensor kinase;
207-332 7.53e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 41.55  E-value: 7.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 207 VTPEllVPEKLVvpTDAKWVGFVLSQVVVNAAKYGAT-HLRFSARVTDgpsggrlTELC--VADDGRGIPARDLPRIFDR 283
Cdd:PRK15347  499 VGAH--VPLYLH--LDSLRLRQILVNLLGNAVKFTETgGIRLRVKRHE-------QQLCftVEDTGCGIDIQQQQQIFTP 567

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1830349217 284 GFTGENGRAGegsTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:PRK15347  568 FYQADTHSQG---TGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-332 7.71e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 38.57  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGATHLRFSARVtdgpSGGRLTeLCVADDGRGIPARDLPRIFDRGFTGENGRA-GEGSTGMGLYLAARI 307
Cdd:cd16939     4 ALDNLLRNALRYAHRTVRIALLV----SGGRLT-LIVEDDGPGIPAAARERVFEPFVRLDPSRDrATGGFGLGLAIVHRV 78

                          90       100
                  ....*....|....*....|....*
gi 1830349217 308 CERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16939    79 ALWHGGHVECDDSELGGACFRLTWP 103
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 222-332 2.39e-03

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 37.09  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 222 DAKWVGFVLSQVVVNAAKYGATHLRFSARVTDGPSGGRLteLCVADDGRGIPARDLPRIFDR--GFTGENGRAgEGSTGM 299
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFL--LTVSDSGPGIPPNLREEIFERfrQGDGSSTRA-HGGTGL 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1830349217 300 GLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16925    78 GLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
PRK09303 PRK09303
histidine kinase;
129-324 2.71e-03

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 39.16  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 129 HEVKAPITAATLA-----AGRQGADGP----------DAVRRELARVSRLVDQALWYARVGSVAADYVIRDTRLADLCra 193
Cdd:PRK09303  160 HDLRTPLTAASLAletleLGQIDEDTElkpalieqlqDQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLC-- 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 194 sckAEA-----RLLIERGVTPELLVPEKL-VVPTDAKWVGFVLSQVVVNAAKYGathlrfsarvtdgPSGGRLT------ 261
Cdd:PRK09303  238 ---QEVileleKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYT-------------PEGGTITlsmlhr 301

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1830349217 262 -----ELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGsTGMGLYLAARICERMGLILEVASEEGEG 324
Cdd:PRK09303  302 ttqkvQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEG-YGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-312 3.91e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 36.60  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 229 VLSQVVVNAAKYGATHLRFsaRVTDGPSGGRLtELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGStGMGLYLAARIC 308
Cdd:cd16923     4 VFSNLLSNAIKYSPENTRI--YITSFLTDDVV-NIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGA-GLGLSIAKAII 79


                  ....
gi 1830349217 309 ERMG 312
Cdd:cd16923    80 ELHG 83
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-332 4.43e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 37.01  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 215 EKLVVPTD-AKWVGFVLSQVVVNAAKYGathlrFSARVTD-----GPSGGRLTELCVADDGRGIPardlprifdRGFTGE 288
Cdd:cd16951    28 DTGPVSSEvATAIGLVVNELLQNALKHA-----FSDREGGtitirSVVDGDYLRITVIDDGVGLP---------QDEDWP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1830349217 289 NgragEGStgMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:cd16951    94 N----KGS--LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 157-332 4.56e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 38.73  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 157 LARVSRLVDQAlwyARVGSVAADYVIRDTrLADLCRASCKAEARLLIErgvTPELLVPEKLVVPtdakwVGFVLSQVVVN 236
Cdd:COG3920   343 LALVHELLYQS---EDWEGVDLRDYLREL-LEPLRDSYGGRGIRIELD---GPDVELPADAAVP-----LGLILNELVTN 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830349217 237 AAKYGAT-----HLRFSARVTDGpsggrLTELCVADDGRGIPArdlprifdrgftgenGRAGEGSTGMGLYLAARICERM 311
Cdd:COG3920   411 ALKHAFLsgeggRIRVSWRREDG-----RLRLTVSDNGVGLPE---------------DVDPPARKGLGLRLIRALVRQL 470

                         170       180
                  ....*....|....*....|.
gi 1830349217 312 GLILEVasEEGEGTRVLVGFP 332
Cdd:COG3920   471 GGTLEL--DRPEGTRVRITFP 489
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 265-332 5.28e-03

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 38.73  E-value: 5.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1830349217 265 VADDGRGIPARDLPRIFdRGFTGENGRagEGSTGMGLYLAARICERMGLILEVASEEGEGTRVLVGFP 332
Cdd:PRK11466  597 VEDSGCGIDPAKLAEIF-QPFVQVSGK--RGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 257-307 5.92e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 35.90  E-value: 5.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1830349217 257 GGRLTELCVADDGRGIPARDLPRIFDRGFTGENGRAGEGSTGMGLYLAARI 307
Cdd:cd16945    33 DTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFVQEV 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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