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Conserved domains on  [gi|1828706245|ref|WP_167589774|]
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acetate/propionate family kinase [Ligilactobacillus agilis]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.-
Gene Ontology:  GO:0016774|GO:0016310|GO:0000287|GO:0005524|GO:0006082|GO:0016301
PubMed:  7883769|23031654|16678422|9484901

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
3-392 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 521.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISY-GKESAQETIPNLTYEQAAQLIITKLQELE-ITSLA 80
Cdd:COG0282     2 KILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGiIKDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  81 DIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYS 160
Cdd:COG0282    82 EIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 161 LPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAG 240
Cdd:COG0282   162 LPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 241 DLDPALVPFLMAELNLDAKQVLELFN-----------SksgllglsglsADMRDIDKAIAAGNKRAELALEIFINRVVKY 309
Cdd:COG0282   242 DIDPGVVLYLMRKEGLSADEVDDLLNkesgllglsgiS-----------SDMRDLEEAAASGDERARLALDMFVYRIKKY 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 310 VGSFYAELGGLDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQEL-TEGVISPADAKVTTLVVPTNEELAMVQEI 388
Cdd:COG0282   311 IGAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARgGERVISTPDSRVKVLVIPTNEELMIARDT 390


                  ....
gi 1828706245 389 KAVM 392
Cdd:COG0282   391 LRLL 394
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
3-392 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 521.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISY-GKESAQETIPNLTYEQAAQLIITKLQELE-ITSLA 80
Cdd:COG0282     2 KILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGiIKDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  81 DIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYS 160
Cdd:COG0282    82 EIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 161 LPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAG 240
Cdd:COG0282   162 LPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 241 DLDPALVPFLMAELNLDAKQVLELFN-----------SksgllglsglsADMRDIDKAIAAGNKRAELALEIFINRVVKY 309
Cdd:COG0282   242 DIDPGVVLYLMRKEGLSADEVDDLLNkesgllglsgiS-----------SDMRDLEEAAASGDERARLALDMFVYRIKKY 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 310 VGSFYAELGGLDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQEL-TEGVISPADAKVTTLVVPTNEELAMVQEI 388
Cdd:COG0282   311 IGAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARgGERVISTPDSRVKVLVIPTNEELMIARDT 390


                  ....
gi 1828706245 389 KAVM 392
Cdd:COG0282   391 LRLL 394
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-392 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 515.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEA--KWEISyGKESAQETIPNLTYEQAAQLIITKLQELE---IT 77
Cdd:PRK00180    2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSriKIKVD-GGEKEEEELPIPDHAEALKFLLNTLTDGKlglIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  78 SLADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNS 157
Cdd:PRK00180   81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 158 IYSLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGT 237
Cdd:PRK00180  161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 238 RAGDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAEL 317
Cdd:PRK00180  241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1828706245 318 -GGLDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQELT---EGVISPADAKVTTLVVPTNEELAMVQEIKAVM 392
Cdd:PRK00180  321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARfgkEGDISTPDSKVKVLVIPTNEELMIARDTLRLL 399
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 4-391 2.85e-171

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 483.55  E-value: 2.85e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   4 ILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISY-GKESAQETIPNLTYEQAAQLIITKLQELEIT-SLAD 81
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVnNGEKIKEELPIPDHEEALKAILDTLTDPELGvSLDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  82 IKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYSL 161
Cdd:cd24010    81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 162 PYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAGD 241
Cdd:cd24010   161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 242 LDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGGLD 321
Cdd:cd24010   241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1828706245 322 VLVFAGGIGENNRTLRQKIAQKLSCLGIVI--ADNLNQELTEGVISPADAKVTTLVVPTNEELAMVQEIKAV 391
Cdd:cd24010   321 AIVFTGGIGENSALIRELVCEGLEFLGIELdeEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-388 1.85e-135

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 392.93  E-value: 1.85e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   1 MPKILLLNAGSSSVKWKLFEIDN-EAVVAKGLVERMLTPEA--KWEISYGKESAQET-IPNltYEQAAQLIITKLQELEI 76
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNAriKWVEDGGKKEAELLaGAD--HQEALKFILNTLLKDKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  77 -TSLADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQA--VMPKTPQYAVFDSRFFTDMP 153
Cdd:TIGR00016  81 iKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKlfPLPKAKNVAVFDTAFHQTMP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 154 EVNSIYSLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGL 233
Cdd:TIGR00016 161 EEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 234 TMGTRAGDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSF 313
Cdd:TIGR00016 241 MMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1828706245 314 YAELGG-LDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQELT---EGVISPADAKVTTLVVPTNEELAMVQEI 388
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARsgkSGVISTPESKVKILVIPTNEELMIAQDA 399
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-386 2.35e-135

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 392.17  E-value: 2.35e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEA--KWEISYGKESAQETiPNLTYEQAAQLIITKLQELEI-TSL 79
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNAriLWKMNGGKKNAALL-AGADHSEALNFILNTLLKHKIiELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  80 ADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIY 159
Cdd:pfam00871  80 AEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 160 SLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRA 239
Cdd:pfam00871 160 ALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 240 GDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGG 319
Cdd:pfam00871 240 GDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLER 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1828706245 320 LDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQELTE-GVISPADAKVTTLVVPTNEELAMVQ 386
Cdd:pfam00871 320 LDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKsGVISTEDSRVKVVVIPTNEELMIAQ 387
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
3-392 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 521.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISY-GKESAQETIPNLTYEQAAQLIITKLQELE-ITSLA 80
Cdd:COG0282     2 KILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGiIKDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  81 DIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYS 160
Cdd:COG0282    82 EIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 161 LPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAG 240
Cdd:COG0282   162 LPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 241 DLDPALVPFLMAELNLDAKQVLELFN-----------SksgllglsglsADMRDIDKAIAAGNKRAELALEIFINRVVKY 309
Cdd:COG0282   242 DIDPGVVLYLMRKEGLSADEVDDLLNkesgllglsgiS-----------SDMRDLEEAAASGDERARLALDMFVYRIKKY 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 310 VGSFYAELGGLDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQEL-TEGVISPADAKVTTLVVPTNEELAMVQEI 388
Cdd:COG0282   311 IGAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARgGERVISTPDSRVKVLVIPTNEELMIARDT 390


                  ....
gi 1828706245 389 KAVM 392
Cdd:COG0282   391 LRLL 394
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-392 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 515.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEA--KWEISyGKESAQETIPNLTYEQAAQLIITKLQELE---IT 77
Cdd:PRK00180    2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSriKIKVD-GGEKEEEELPIPDHAEALKFLLNTLTDGKlglIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  78 SLADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNS 157
Cdd:PRK00180   81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 158 IYSLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGT 237
Cdd:PRK00180  161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 238 RAGDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAEL 317
Cdd:PRK00180  241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1828706245 318 -GGLDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQELT---EGVISPADAKVTTLVVPTNEELAMVQEIKAVM 392
Cdd:PRK00180  321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARfgkEGDISTPDSKVKVLVIPTNEELMIARDTLRLL 399
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 4-391 2.85e-171

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 483.55  E-value: 2.85e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   4 ILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISY-GKESAQETIPNLTYEQAAQLIITKLQELEIT-SLAD 81
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVnNGEKIKEELPIPDHEEALKAILDTLTDPELGvSLDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  82 IKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYSL 161
Cdd:cd24010    81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 162 PYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAGD 241
Cdd:cd24010   161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 242 LDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGGLD 321
Cdd:cd24010   241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1828706245 322 VLVFAGGIGENNRTLRQKIAQKLSCLGIVI--ADNLNQELTEGVISPADAKVTTLVVPTNEELAMVQEIKAV 391
Cdd:cd24010   321 AIVFTGGIGENSALIRELVCEGLEFLGIELdeEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-388 1.85e-135

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 392.93  E-value: 1.85e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   1 MPKILLLNAGSSSVKWKLFEIDN-EAVVAKGLVERMLTPEA--KWEISYGKESAQET-IPNltYEQAAQLIITKLQELEI 76
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNAriKWVEDGGKKEAELLaGAD--HQEALKFILNTLLKDKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  77 -TSLADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQA--VMPKTPQYAVFDSRFFTDMP 153
Cdd:TIGR00016  81 iKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKlfPLPKAKNVAVFDTAFHQTMP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 154 EVNSIYSLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGL 233
Cdd:TIGR00016 161 EEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 234 TMGTRAGDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSF 313
Cdd:TIGR00016 241 MMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1828706245 314 YAELGG-LDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQELT---EGVISPADAKVTTLVVPTNEELAMVQEI 388
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARsgkSGVISTPESKVKILVIPTNEELMIAQDA 399
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-386 2.35e-135

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 392.17  E-value: 2.35e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEA--KWEISYGKESAQETiPNLTYEQAAQLIITKLQELEI-TSL 79
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNAriLWKMNGGKKNAALL-AGADHSEALNFILNTLLKHKIiELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  80 ADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIY 159
Cdd:pfam00871  80 AEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 160 SLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRA 239
Cdd:pfam00871 160 ALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 240 GDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGG 319
Cdd:pfam00871 240 GDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLER 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1828706245 320 LDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQELTE-GVISPADAKVTTLVVPTNEELAMVQ 386
Cdd:pfam00871 320 LDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKsGVISTEDSRVKVVVIPTNEELMIAQ 387
PRK12397 PRK12397
acetate/propionate family kinase;
3-388 9.71e-121

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 355.69  E-value: 9.71e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISYGKESAQETIPNLTYEQAAQLIITKLQELE-ITSLAD 81
Cdd:PRK12397    4 KIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQKWQETVPVADHRDAVTLLLEKLLGYQiINSLRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  82 IKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYSL 161
Cdd:PRK12397   84 IDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYIYPL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 162 PYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAGD 241
Cdd:PRK12397  164 PWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTRSGD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 242 LDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGGLD 321
Cdd:PRK12397  244 IDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMGGLD 323

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1828706245 322 VLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQElTEGVISPADAKVTTLVVPTNEELAMVQEI 388
Cdd:PRK12397  324 ALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR-NATFIQTENALVKVAVINTNEELMIAQDV 389
PRK07157 PRK07157
acetate kinase; Provisional
 1-391 3.02e-111

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 331.32  E-value: 3.02e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   1 MPKILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISYGKESAQETIPNLTYEQAAQLIITKLQELE-ITSL 79
Cdd:PRK07157    2 KAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKlIEDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  80 ADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIY 159
Cdd:PRK07157   82 EEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYTY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 160 SLPYELTEKYGLRKYGEHGISHTYISKRAATLLGKDlaDLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRA 239
Cdd:PRK07157  162 PINYEIAKKYGIKKYGFHGISHKFITNKVEKILNKD--KVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTRS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 240 GDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGG 319
Cdd:PRK07157  240 GDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKIGK 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1828706245 320 -LDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQE-----LTEGVISPADAKVTTLVVPTNEELAMVQEIKAV 391
Cdd:PRK07157  320 kIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKkigeyGPIELISTPDSDIPVYVIRTNEELLIAKNAIKL 397
PRK12379 PRK12379
propionate kinase;
2-381 8.53e-99

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 299.34  E-value: 8.53e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   2 PKILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISyGKESAQETIPNltYEQAAQLIITKLQELEITSlaD 81
Cdd:PRK12379    5 PVVLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVN-GGEPAPLAHHS--YEGALKAIAFELEKRNLND--S 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  82 IKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYSL 161
Cdd:PRK12379   80 VALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 162 PYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAGD 241
Cdd:PRK12379  160 PWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 242 LDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGGLD 321
Cdd:PRK12379  240 VDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLD 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1828706245 322 VLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQEL---TEGVISPADAKVTTLVVPTNEE 381
Cdd:PRK12379  320 GIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPnsgGERIISSENSRVICAVIPTNEE 382
PRK12440 PRK12440
acetate/propionate family kinase;
4-387 3.18e-96

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 292.92  E-value: 3.18e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   4 ILLLNAGSSSVKWKLFEIDNEAVVAKGLVERMLTPEAKWEISYGKESAQETIP--NLTYEQAAQLIITKLQELEITSlaD 81
Cdd:PRK12440    6 VLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKYQGEKTEIAIEgeDNHHKIAIGRLVGLTEELGFTQ--D 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  82 IKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMPEVNSIYSL 161
Cdd:PRK12440   84 IVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGAI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 162 PYELTEKYGLRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGLTMGTRAGD 241
Cdd:PRK12440  164 AKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCGD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 242 LDPALVPFLMAElNLDAKQVLELFNSKSGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGGLD 321
Cdd:PRK12440  244 LDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAALDSLD 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 322 VLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQEL---TEGVISPADA-KVTTLVVPTNEELAMVQE 387
Cdd:PRK12440  323 GIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDArfgKAGIIAKSELlNAVAMVIPTNEEFVIAQQ 392
PRK07058 PRK07058
acetate/propionate family kinase;
1-392 2.44e-73

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 233.79  E-value: 2.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   1 MPKILL-LNAGSSSVKWKLFEIDNEAV--VAKGLVERMLTPeAKWEISYGKESAqeTIPnLTYEQAAQL---IITKLQEL 74
Cdd:PRK07058    2 SKPLLLtFNAGSSTVKIGLFEVDGNEArrIGKGDIDFRRAP-LRFHLRNGGETL--DIP-LKASVTDDLhtvLDETFDWL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  75 EIT-SLADIKAVGHRVVAGGHTFKQATLVDEEALDQIKQLSSHAPLHNPMEAKYIELMQAVMPKTPQYAVFDSRFFTDMP 153
Cdd:PRK07058   78 AAHfDVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 154 EVNSIYSLPYELTEKyGLRKYGEHGISHTYISKRAAtLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMGFTPLTGL 233
Cdd:PRK07058  158 DLVRRFAIPRALHDE-GIKRYGFHGLSYKFVAGELR-RRAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 234 TMGTRAGDLDPALVPFLMAELNLDAKQVLELFNSKSGLLGLSGLSADMRDIdkaIAAGNKRAELALEIFINRVVKYVGSF 313
Cdd:PRK07058  236 PMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDL---LASDAPEAREALDLFALRIAGEIARL 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1828706245 314 YAELGGLDVLVFAGGIGENNRTLRQKIAQKLSCLGIVIADNLNQElTEGVISPADAKVTTLVVPTNEELAMVQEIKAVM 392
Cdd:PRK07058  313 AATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAA-NAFTISSRTSRVAAFVIPTDEEQVIADEAFSVL 390
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 3-351 1.02e-20

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 92.21  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245   3 KILLLNAGSSSVKWKLFEIDNEavvakgLVERMLTPEAKWEISYGKESAQetipnltYEQAAQLIITKLQELEItSLADI 82
Cdd:cd24011     1 RILVINPGSTSTKIAVFEGEEE------VFEETIEHSPEELAKFPSIIDQ-------LEFRKEAVLDFLKENGI-DLSDL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245  83 KAVGHRV-----VAGGhtfkqATLVDEEALDQIKQ--LSSHAPLHNPMEAKyiELMQAVmpKTPQYAVfDSRFFTDMPEV 155
Cdd:cd24011    67 DAIVGRGgllkpIPGG-----TYRVNEAMLEDLLSgpLGEHASNLGAPIAY--ELAKEY--GIPAYIV-DPVVVDEMDPV 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 156 NSIYSLPyELTekyglRKYGEHGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMG------FTP 229
Cdd:cd24011   137 ARITGIP-EIE-----RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSP 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 230 ltgltmgTRAGDLD-PALVPfLMAELNLDAKQVLELFNSKsGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVK 308
Cdd:cd24011   211 -------ERAGTLPvGDLIK-LCFSGKYTLEELKKKLKGK-GGLVAYLGTNDFREVEKRIEAGDEKAKLVLDAMAYQIAK 281

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1828706245 309 YVGSFYAELGG-LDVLVFAGGIGENNRtLRQKIAQKLSCLGIVI 351
Cdd:cd24011   282 EIGALAAVLKGkVDAIILTGGLAYSKR-LVDRIKERVGFIAPVI 324
PRK03011 PRK03011
butyrate kinase; Provisional
 177-351 1.95e-15

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 76.74  E-value: 1.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 177 HGISHTYISKRAATLLGKDLADLKMITLHLGSGSSVAALKDGKAYDTSMG------FTPLtgltmgtRAGDLdPALvPFL 250
Cdd:PRK03011  154 HALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSPE-------RAGGL-PVG-DLV 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828706245 251 maEL----NLDAKQVLELFNSKsGLLGLSGLSADMRDIDKAIAAGNKRAELALEIFINRVVKYVGSFYAELGG-LDVLVF 325
Cdd:PRK03011  225 --ELcfsgKYTKEELKKKLVGK-GGLVAYLGTNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDAIVL 301

                         170       180
                  ....*....|....*....|....*.
gi 1828706245 326 AGGIgENNRTLRQKIAQKLSCLGIVI 351
Cdd:PRK03011  302 TGGL-AYSKRLVERIKERVSFIAPVI 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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