NCBI Conserved Domain Search

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

563-1887

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 835.28 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  563 RIEPRPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPV 642
Cdd:COG1020     10 PPAAAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPV 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  643 AVAREQL--------DWREADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHVAL-TMHHIAMDGQSIPVLARDLMSA 713
Cdd:COG1020     90 VAAPLPVvvllvdleALAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLlALHHIISDGLSDGLLLAELLRL 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  714 YAARAEGRTGGLPVLDVQYADYALWQQsvlgdADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVE 793
Cdd:COG1020    170 YLAAYAGAPLPLPPLPIQYADYALWQR-----EWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRGARVSFR 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  794 FDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGD 873
Cdd:COG1020    245 LPAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRPELEGLVGFFVNTLPLRVDLSGDPSFAE 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  874 LLGNVRTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEptvNDVAGLEASGIQAAPVDTGVVNAKFDLTVA 953
Cdd:COG1020    325 LLARVRETLLAAYAHQDLPFERLVEELQPERDLSRNPLFQVMFVLQN---APADELELPGLTLEPLELDSGTAKFDLTLT 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  954 VRARSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAA-RAKSVSAPVSARTPGAmvgrgg 1032
Cdd:COG1020    402 VVETGDG--LRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAeRQQLLAEWNATAAPYP------ 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1033 evEAGTLID-VLAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGA 1111
Cdd:COG1020    474 --ADATLHElFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGA 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1112 AYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGDDitdteRNGSVRLTNLAYLIYTS 1191
Cdd:COG1020    552 AYVPLDPAYPAERLAYMLEDAGARLVLTQSALAARLPELGVPVLALDALALAAEPATN-----PPVPVTPDDLAYVIYTS 626

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1192 GSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFA-GDALAT 1270
Cdd:COG1020    627 GSTGRPKGVMVEHRALVNLLAWMQRRYGLGPGD----RVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRdPAALAE 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1271 VLERDEVTDMIITPSVLATV---DPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRMTA-- 1343
Cdd:COG1020    703 LLARHRVTVLNLTPSLLRALldaAPEALPSLRLVLVGGEALPPELVRRWRARlpGARLVNLYGPTETTVDSTYYEVTPpd 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 --GKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAK 1421
Cdd:COG1020    783 adGGSVPIGRPIANTRVYVLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWLP 862

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1422 GGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQH 1501
Cdd:COG1020    863 DGNLEFLGRADDQVKIRGFRIELGEIEAALLQHPGVREAVVVAREDAPGDK---RLVAYVVPEAGAAAAAALLRLALALL 939

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1502 LAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPEPAEYVAPANPAEDNLARIVAGLLGEERVSVTESFFALGGDSIMS 1581
Cdd:COG1020    940 LPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLL 1019

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1582 IQLSSAAKAAGIHLSPREIFELKTIRAMAAAAAASGGPVALIEELPGGGtgemPLPPVTSWMIEHSEEPADFADFSQSLV 1661
Cdd:COG1020   1020 LLALARAARLLLLLLLLLLLFLAAAAAAAAAAAAAAAAAAAAPLAAAAA----PLPLPPLLLSLLALLLALLLLLALLAL 1095

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1662 FNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTMNAGAGIVPAVREIDAEGALDPALVDAHRELLGAM------- 1734
Cdd:COG1020   1096 LALLLLLLLLLLLLALLLLLALLLALLAALRARRAVRQEGPRLRLLVALAAALALAALLALLLAAAAAAAELLaaaalll 1175

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1735 -DPGTGSLLGTAVVNGEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEATTTRRIAHLLAGQVHARA 1813
Cdd:COG1020   1176 lLALLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAAL 1255

                         1290      1300      1310      1320      1330      1340      1350
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 1814 REVDYWLEQLPERPTSFGTSADRPLHRRRDESSLTYVVDDVAGSILTTVPQAFGSSVDDVLLGALARAVRAWQL 1887
Cdd:COG1020   1256 AAALLALALALLALALLLLALALLLPALARARAARTARALALLLLLALLLLLALALALLLLLLLLLALLLLALL 1329

LCL_NRPS-like

cd19540

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

570-996

4.25e-166

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 520.06 E-value: 4.25e-166

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVAVAREQL 649
Cdd:cd19540      1 RIPLSFAQQRLWFLNRLDGPSAAYNIPLALRLTGALDVDALRAALADVVARHESLRTVFPEDDGGPYQVVLPAAEARPDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  650 DWR---EADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARAEGRTGGL 725
Cdd:cd19540     81 TVVdvtEDELAARLAEAARRGFDLTAELPLRARLFRLGPDEHVlVLVVHHIAADGWSMAPLARDLATAYAARRAGRAPDW 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  726 PVLDVQYADYALWQQSVLGDADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRVDVL 805
Cdd:cd19540    161 APLPVQYADYALWQRELLGDEDDPDSLAARQLAYWRETLAGLPEELELPTDRPRPAVASYRGGTVEFTIDAELHARLAAL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  806 ARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTTVLDA 885
Cdd:cd19540    241 AREHGATLFMVLHAALAVLLSRLGAGDDIPIGTPVAGRGDEALDDLVGMFVNTLVLRTDVSGDPTFAELLARVRETDLAA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  886 FANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEptvNDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRARSG--GTP- 962
Cdd:cd19540    321 FAHQDVPFERLVEALNPPRSTARHPLFQVMLAFQN---TAAATLELPGLTVEPVPVDTGVAKFDLSFTLTERRDadGAPa 397

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1827387616  963 -MAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19540    398 gLTGELEYATDLFDRSTAERLADRFVRVLEAVVAD 432

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

4-407

5.77e-138

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 438.24 E-value: 5.77e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLAREL-TALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDG 82
Cdd:TIGR01733    3 RELDERANRLARHLrAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSAL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   83 EAEARSRFDDIVDVHVLDiSSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTAR 162
Cdd:TIGR01733   83 ASRLAGLVLPVILLDPLE-LAALDDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDPD 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  163 DVFLYKAPITFDVSVREIFLPIAIGATLVIAEPG-RHGDPVHLADLIRRHGVTVIHFVPAMLAAFnevLGAGVGELTSLR 241
Cdd:TIGR01733  162 DRVLQFASLSFDASVEEIFGALLAGATLVVPPEDeERDDAALLAALIAEHPVTVLNLTPSLLALL---AAALPPALASLR 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  242 LIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD----RVIPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:TIGR01733  239 LVILGGEALTPALVDRWRARGPGARLINLYGPTETTVWSTATLVDPDDapreSPVPIGRPLANTRLYVLDDDLRPVPVGV 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPF-GEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAAL 396
Cdd:TIGR01733  319 VGELYIGGPGVARGYLNRPELTAERFVPDPFaGGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAAL 398

                          410
                   ....*....|.
gi 1827387616  397 AAAPGVLHAAA 407
Cdd:TIGR01733  399 LRHPGVREAVV 409

AMP-binding

AMP-binding enzyme;

1-383

1.33e-90

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 302.31 E-value: 1.33e-90

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:pfam00501   22 LTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRLPAEELAYILEDSGAKVLITDD 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVDVHVLDISSPGDADLDEEEFAG-------------PTRPANAAFTLFTSGSTGRPKAVVITHRGIA 147
Cdd:pfam00501  102 ALKLEELLEALGKLEVVKLVLVLDRDPVLKEEPLPEeakpadvppppppPPDPDDLAYIIYTSGTTGKPKGVMLTHRNLV 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  148 NRLAA----DIEQYDLTARDVFLYKAPITFDVSVR-EIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAM 222
Cdd:pfam00501  182 ANVLSikrvRPRGFGLGPDDRVLSTLPLFHDFGLSlGLLGPLLAGATVVLPPGFPALDPAALLELIERYKVTVLYGVPTL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  223 LAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTrLQNQYGPAEASIVVTIHRVTQDDRVIP--IGTPTRR 300
Cdd:pfam00501  262 LNMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRFRELFGGA-LVNGYGLTETTGVVTTPLPLDEDLRSLgsVGRPLPG 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  301 VSARVLDAA-LREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgaRLYRTGDRARWNRDGEIEYLGRTDFQ 379
Cdd:pfam00501  341 TEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDED-------GWYRTGDLGRRDEDGYLEIVGRKKDQ 413


                   ....
gi 1827387616  380 VKLR 383
Cdd:pfam00501  414 IKLG 417

PKS_PP

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...

3080-3142

4.68e-09

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.

Pssm-ID: 214834 [Multi-domain] Cd Length: 86 Bit Score: 55.72 E-value: 4.68e-09

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  3080 IADVAAGVLNIDAG-LVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAE 3142
Cdd:smart00823   17 VREQVAAVLGHAAAeAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAE 80

Name

Accession

Description

Interval

E-value

PRK12467

peptide synthase; Provisional

1-3146

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 2091.72 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvts 80
Cdd:PRK12467   538 LSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEYPQDRLAYMLDDSGVRLLL--- 614

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dGEAEARSRFDDIVDVHVLDISSPGDADLDEEEFAGPTR--PANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYD 158
Cdd:PRK12467   615 -TQSHLLAQLPVPAGLRSLCLDEPADLLCGYSGHNPEVAldPDNLAYVIYTSGSTGQPKGVAISHGALANYVCVIAERLQ 693

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  159 LTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVlgAGVGELT 238
Cdd:PRK12467   694 LAADDSMLMVSTFAFDLGVTELFGALASGATLHLLPPDCARDAEAFAALMADQGVTVLKIVPSHLQALLQA--SRVALPR 771

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 SLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVI---PIGTPTRRVSARVLDAALREVPI 315
Cdd:PRK12467   772 PQRALVCGGEALQVDLLARVRALGPGARLINHYGPTETTVGVSTYELSDEERDFgnvPIGQPLANLGLYILDHYLNPVPV 851

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  316 GVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:PRK12467   852 GVVGELYIGGAGLARGYHRRPALTAERFVPDPFGADGGRLYRTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEAR 931

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  396 LAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVD--------VDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRL 467
Cdd:PRK12467   932 LLAQPGVREAVVLAQPGDAGLQLVAYLVPAAVAdgaehqatRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKA 1011

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  468 LPEPEIAPT--LYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVR 545
Cdd:PRK12467  1012 LPKPDASAVqaTFVAPQTELEKRLAAIWADVLKVERVGLTDNFFELGGHSLLATQVISRVRQRLGIQVPLRTLFEHQTLA 1091

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  546 GLVHAVS----GRGSALPSVKRIEPrperLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERH 621
Cdd:PRK12467  1092 GFAQAVAaqqqGAQPALPDVDRDQP----LPLSYAQERQWFLWQLEPGSAAYHIPQALRLKGPLDIEALERSFDALVARH 1167

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  622 EVLRTVYPSVGAAPVQ---DVLPVAVAREQLDWREADSVESLVRSTTEG---FDVSTQMPLRGRFHRDGAGLHV-ALTMH 694
Cdd:PRK12467  1168 ESLRTTFVQEDGRTRQvihPVGSLTLEEPLLLAADKDEAQLKVYVEAEArqpFDLEQGPLLRVGLLRLAADEHVlVLTLH 1247

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  695 HIAMDGQSIPVLARDLMSAYAARAEGRTGGLPVLDVQYADYALWQQSVLGDADDEtsvlgEQLSHWRRVLAGLPAVTDLP 774
Cdd:PRK12467  1248 HIVSDGWSMQVLVDELVALYAAYSQGQSLQLPALPIQYADYAVWQRQWMDAGERA-----RQLAYWKAQLGGEQPVLELP 1322

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  775 MDRPRPAVLGTAGATVTVEFDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGM 854
Cdd:PRK12467  1323 TDRPRPAVQSHRGARLAFELPPALAEGLRALARREGVTLFMLLLASFQTLLHRYSGQDDIRVGVPIANRNRAETEGLIGF 1402

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  855 FVNTLLLRTQVDPGHSVGDLLGNVRTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTeptvNDVAGLEAS-- 932
Cdd:PRK12467  1403 FVNTQVLRAEVDGQASFQQLLQQVKQAALEAQAHQDLPFEQLVEALQPERSLSHSPLFQVMFNHQ----RDDHQAQAQlp 1478

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  933 GIQAAPVDTGVVNAKFDLTVAVRARSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAARA 1012
Cdd:PRK12467  1479 GLSVESLSWESQTAQFDLTLDTYESSEG--LQASLTYATDLFEASTIERLAGHWLNLLQGLVADPERRLGELDLLDEAER 1556

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1013 KSV----SAPVSARTPGAMVGRGGEVEAGTlidvlaqrdlDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDV 1088
Cdd:PRK12467  1557 RQIlegwNATHTGYPLARLVHQLIEDQAAA----------TPEAVALVFGEQELTYGELNRRANRLAHRLIALGVGPEVL 1626

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1089 VAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGD 1168
Cdd:PRK12467  1627 VGIAVERSLEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQSHLQARLPLPDGLRSLVLDQEDDWLEGY 1706

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1169 DITDTERNGSVRltNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDEpdtrILHVASPSFDASMFEMAWA 1248
Cdd:PRK12467  1707 SDSNPAVNLAPQ--NLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEAYQLSAADV----VLQFTSFAFDVSVWELFWP 1780

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1249 IPAGHTLVIA-PQADFAGDALATVLERDEVTDMIITPSVL---ATVDP--ERAQYVRNLATGGEACPPELVERWSER--G 1320
Cdd:PRK12467  1781 LINGARLVIApPGAHRDPEQLIQLIERQQVTTLHFVPSMLqqlLQMDEqvEHPLSLRRVVCGGEALEVEALRPWLERlpD 1860

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1321 RRIFNCYGPTEATV----W-ATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTA 1395
Cdd:PRK12467  1861 TGLFNLYGPTETAVdvthWtCRRKDLEGRDSVPIGQPIANLSTYILDASLNPVPIGVAGELYLGGVGLARGYLNRPALTA 1940

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1396 VSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVEstrgGRKHT 1475
Cdd:PRK12467  1941 ERFVADPFGTVGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLREQGGVREAVVIAQD----GANGK 2016

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1476 EVVAYLVAK----PGATIDSAAVLDEAAQHLAA----HMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPEPAE-YVAPAN 1546
Cdd:PRK12467  2017 QLVAYVVPTdpglVDDDEAQVALRAILKNHLKAslpeYMVPAHLVFLARMPLTPNGKLDRKALPAPDASELQQaYVAPQS 2096

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1547 PAEDNLARIVAGLLGEERVSVTESFFALGGDSIMSIQLSSAAKAAGIHLSPREIFELKTIRAMAAAAAASGGPVALIEel 1626
Cdd:PRK12467  2097 ELEQRLAAIWQDVLGLEQVGLHDNFFELGGDSIISIQVVSRARQAGIRFTPKDLFQHQTVQSLAAVAQEGDGTVSIDQ-- 2174

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1627 pGGGTGEMPLPPVTSWMIEhsEEPADFADFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTmnagAGI 1706
Cdd:PRK12467  2175 -GPVTGDLPLLPIQQMFFA--DDIPERHHWNQSVLLEPREALDAELLEAALQALLVHHDALRLGFVQEDGGWS----AMH 2247

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1707 VPAVRE---------IDAEGALDPALVDAHRELlgamDPGTGSLLGTAVV-NGEGRRRLVIAIHHLGVDAVSWPILVEDL 1776
Cdd:PRK12467  2248 RAPEQErrpllwqvvVADKEELEALCEQAQRSL----DLEEGPLLRAVLAtLPDGSQRLLLVIHHLVVDGVSWRILLEDL 2323

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1777 VTAWAQLTSGRPIELRPEATTTRRIAHLLagQVHAR----AREVDYWLEQLPERPTsfGTSADRP---LHRRRDESSLTY 1849
Cdd:PRK12467  2324 QTAYRQLQGGQPVKLPAKTSAFKAWAERL--QTYAAsaalADELGYWQAQLQGAST--ELPCDHPqggLQRRHAASVTTH 2399

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1850 VVDDVAGSILTTVPQAFGSSVDDVLLGALARAVRAWqldNGIADggpVTVSTEGHGRDESIAGdegaIDLSRTVGWFTSI 1929
Cdd:PRK12467  2400 LDSEWTRRLLQEAPAAYRTQVNDLLLTALARVIARW---TGQAS---TLIQLEGHGREDLFDE----IDLTRTVGWFTSL 2469

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1930 TPLAVDASSDVVHAVKSAKDARLSRPAGGVGFGILRYNSDGEIAHR----PLPTIMYNYFGGGTAPSTETAPDDFLPVSD 2005
Cdd:PRK12467  2470 YPVKLSPTASLATSIKTIKEQLRAVPNKGLGFGVLRYLGSEAARQTlqalPVPRITFNYLGQFDGSFDAEKQALFVPSGE 2549

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2006 RpnmpssiTGAMRSPSV-----FGINISTAGREerrLEAKVTYATDALDEAAASDIARRWHDELRAVVELVDGGAEIGLS 2080
Cdd:PRK12467  2550 F-------SGAEQSEEAplgnwLSINGQVYGGE---LNLGWTFSQEMFDEATIQRLADAYAEELRALIEHCCSNDQRGVT 2619

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2081 RADVPGVEVTQDDLD---LIAQQYpgADVWPMTPLQQGLFFQadlanTVADHDAiDVYVTQTVLSLTGdVDPGRLRSALS 2157
Cdd:PRK12467  2620 PSDFPLAGLSQEQLDrlpVAVGDI--EDIYPLSPMQQGMLFH-----TLYEGGA-GDYINQMRVDVEG-LDVERFRTAWQ 2690

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2158 ELLARQRVLRSGFVRLPS-GAAVTVVPAEVTVPWSVIDLRaeDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHG- 2235
Cdd:PRK12467  2691 AVIDRHEILRSGFLWDGElEEPLQVVYKQARLPFSRLDWR--DRADLEQALDALAAADRQQGFDLLSAPLLRLTLVRTGe 2768

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2236 DGAELVVTNHHLLIDGWSSPLVLADLLSLYaTGQTftgsLPGTSGRdFADHARAVATADVEAGIAAWREVLAPVTEPTLV 2315
Cdd:PRK12467  2769 DRHHLIYTNHHILMDGWSGSQLLGEVLQRY-FGQP----PPAREGR-YRDYIAWLQAQDAEASEAFWKEQLAALEEPTRL 2842

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2316 APGHEPsADAPPR----DHQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGME 2391
Cdd:PRK12467  2843 ARALYP-APAEAVaghgAHYLHLDATQTRQLIEFARRHRVTLNTLVQGAWLLLLQRFTGQDTVCFGATVAGRPAQLRGAE 2921

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2392 SMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLP--ALFDTLAVYESFPVNvdsvAGIDA 2469
Cdd:PRK12467  2922 QQLGLFINTLPVIASPRAEQTVSDWLQQVQAQNLALREFEHTPLADIQRWAGQGgeALFDSILVFENYPIS----EALKQ 2997

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2470 SSAGGLKLVGAKTSDATHYPLNLsASRRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEA 2549
Cdd:PRK12467  2998 GAPSGLRFGAVSSREQTNYPLTL-AVGLGDTLELEFSYDRQHFDAAAIERLAESFDRLLQAMLNNPAARLGELPTLAAHE 3076

                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2550 AVELTPVTGGPATDPVT---LAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRS 2626
Cdd:PRK12467  3077 RRQVLHAWNATAAAYPSerlVHQLIEAQVARTPEAPALVFG-DQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERS 3155

                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2627 AQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLS---VLASGDLPGQEFEWMrLDDDSVAAEIAAVPAgPI 2703
Cdd:PRK12467  3156 VEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIEDSGVKLLLTqahLLEQLPAPAGDTALT-LDRLDLNGYSENNPS-TR 3233

                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2704 TDAErlgevtaaNLAYVIYTSGSTGRPKGVAVTHSGLANFAR--QESDRLNAGDNpvVLGFASPSFDASVLEYLLATVNE 2781
Cdd:PRK12467  3234 VMGE--------NLAYVIYTSGSTGKPKGVGVRHGALANHLCwiAEAYELDANDR--VLLFMSFSFDGAQERFLWTLICG 3303

                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2782 GTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLSTM----DPTAVPSLRVIAAGGEAVP---QPIVDRWAPATELHNL 2854
Cdd:PRK12467  3304 GCLVVRDNDLWDPEELWQAIHAHRISIACFPPAYLQQFaedaGGADCASLDIYVFGGEAVPpaaFEQVKRKLKPRGLTNG 3383

                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 YGPTETTIGITI----SSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTAN 2930
Cdd:PRK12467  3384 YGPTEAVVTVTLwkcgGDAVCEAPYAPIGRPVAGRSIYVLDGQLNPVPVGVAGELYIGGVGLARGYHQRPSLTAERFVAD 3463

                         3050      3060      3070      3080      3090      3100      3110      3120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2931 PYGTAGQRMYRTGDVVRWTPDtdtgGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAY 3010
Cdd:PRK12467  3464 PFSGSGGRLYRTGDLARYRAD----GV-IEYLGRIDHQVKIRGFRIELGEIEARLLQHPSVREAVVLARDGAGGKQLVAY 3538

                         3130      3140      3150      3160      3170      3180      3190      3200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3011 IVPVD-GAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLE-AGEYVAPATGTERTIADVAAGVL 3088
Cdd:PRK12467  3539 VVPADpQGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKALPDPDAKgSREYVAPRSEVEQQLAAIWADVL 3618

                         3210      3220      3230      3240      3250
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 3089 NIDAglVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAETVGG 3146
Cdd:PRK12467  3619 GVEQ--VGVTDNFFELGGDSLLALQVLSRIRQSLGLKLSLRDLMSAPTIAELAGYSPL 3674

PRK12316

peptide synthase; Provisional

1-3142

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 1924.34 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK12316  2029 LSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTQR 2108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAearsRFDDIVDVHVLDISSPGD-ADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDL 159
Cdd:PRK12316  2109 HLLE----RLPLPAGVARLPLDRDAEwADYPDTAPAVQLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYEL 2184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARDVFLYKAPITFDVSVREIFLPIAIGATlVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLgAGVGELTS 239
Cdd:PRK12316  2185 SPADCELQFMSFSFDGAHEQWFHPLLNGAR-VLIRDDELWDPEQLYDEMERHGVTILDFPPVYLQQLAEHA-ERDGRPPA 2262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD----RVIPIGTPTRRVSARVLDAALREVPI 315
Cdd:PRK12316  2263 VRVYCFGGEAVPAASLRLAWEALRPVYLFNGYGPTEAVVTPLLWKCRPQDpcgaAYVPIGRALGNRRAYILDADLNLLAP 2342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  316 GVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:PRK12316  2343 GMAGELYLGGEGLARGYLNRPGLTAERFVPDPFSASGERLYRTGDLARYRADGVVEYLGRIDHQVKIRGFRIELGEIEAR 2422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  396 LAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVDTVAATTAEL---LPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPE 472
Cdd:PRK12316  2423 LQAHPAVREAVVVAQDGASGKQLVAYVVPDDAAEDLLAELRAWLaarLPAYMVPAHWVVLERLPLNPNGKLDRKALPKPD 2502

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  473 IAP--TLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVRGLVHA 550
Cdd:PRK12316  2503 VSQlrQAYVAPQEGLEQRLAAIWQAVLKVEQVGLDDHFFELGGHSLLATQVVSRVRQDLGLEVPLRILFERPTLAAFAAS 2582

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  551 VSGRGSALPSVKRIEPRPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPS 630
Cdd:PRK12316  2583 LESGQTSRAPVLQKVTRVQPLPLSHAQQRQWFLWQLEPESAAYHLPSALHLRGVLDQAALEQAFDALVLRHETLRTRFVE 2662

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  631 VGAAPVQDVLPVAVAREQLDWREADSVESLVRSTTE----GFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPV 705
Cdd:PRK12316  2663 VGEQTRQVILPNMSLRIVLEDCAGVADAAIRQRVAEeiqrPFDLARGPLLRVRLLALDGQEHVlVITQHHIVSDGWSMQV 2742

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  706 LARDLMSAYAARAEGRTGGLPVLDVQYADYALWQQSVLgdaddETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGT 785
Cdd:PRK12316  2743 MVDELVQAYAGARRGEQPTLPPLPLQYADYAAWQRAWM-----DSGEGARQLDYWRERLGGEQPVLELPLDRPRPALQSH 2817

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  786 AGATVTVEFDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQV 865
Cdd:PRK12316  2818 RGARLDVALDVALSRELLALARREGVTLFMLLLASFQVLLHRYSGQSDIRVGVPIANRNRAETERLIGFFVNTQVLRAQV 2897

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  866 DPGHSVGDLLGNVRTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEptvNDVAGLEASGIQAAPVDTGVVN 945
Cdd:PRK12316  2898 DAQLAFRDLLGQVKEQALGAQAHQDLPFEQLVEALQPERSLSHSPLFQVMYNHQS---GERAAAQLPGLHIESFAWDGAA 2974

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  946 AKFDLTVAVRARSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAA---RAKSVSAPVSAR 1022
Cdd:PRK12316  2975 TQFDLALDTWESAEG--LGASLTYATDLFDARTVERLARHWQNLLRGMVENPQRSVDELAMLDAEergQLLEAWNATAAE 3052

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1023 TPgamvgrggeVEAGTLIDVLAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLA 1102
Cdd:PRK12316  3053 YP---------LERGVHRLFEEQVERTPDAVALAFGEQRLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVG 3123

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1103 TWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGItdasTRARLGESSCEWVDLADLEAEAESGdditdTERNGSVRLT 1182
Cdd:PRK12316  3124 LLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLL----SQSHLRLPLAQGVQVLDLDRGDENY-----AEANPAIRTM 3194

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 --NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQ 1260
Cdd:PRK12316  3195 peNLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGD----RVLQFTTFSFDVFVEELFWPLMSGARVVLAGP 3270

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1261 ADFAGDALATVLERDEVTDMI-ITPSV----LATVDPERAQYVRNLATGGEACPPELVERWSErGRRIFNCYGPTEATVW 1335
Cdd:PRK12316  3271 EDWRDPALLVELINSEGVDVLhAYPSMlqafLEEEDAHRCTSLKRIVCGGEALPADLQQQVFA-GLPLYNLYGPTEATIT 3349

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1336 ATRSRMTAGKPVT--IGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgEPGARMYAT 1413
Cdd:PRK12316  3350 VTHWQCVEEGKDAvpIGRPIANRACYILDGSLEPVPVGALGELYLGGEGLARGYHNRPGLTAERFVPDPF-VPGERLYRT 3428

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1414 GDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRggrkhteVVAYLVAKPGATIDSAA 1493
Cdd:PRK12316  3429 GDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVREAVVLAVDGRQ-------LVAYVVPEDEAGDLREA 3501

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1494 VLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPE-PAEYVAPANPAEDNLARIVAGLLGEERVSVTESFF 1572
Cdd:PRK12316  3502 LKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKALPRPDAALlQQDYVAPVNELERRLAAIWADVLKLEQVGLTDNFF 3581

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1573 ALGGDSIMSIQLSSAAKAAGIHLSPREIFELKTIRAMAAAAAASGGpvALIEElpGGGTGEMPLPPVTSWMIEhsEEPAD 1652
Cdd:PRK12316  3582 ELGGDSIISLQVVSRARQAGIRFTPKDLFQHQTIQGLARVARVGGG--VAVDQ--GPVSGETLLLPIQQQFFE--EPVPE 3655

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1653 FADFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTMNAGAGIVPAVREIDAEGALDPALVDAHRELLG 1732
Cdd:PRK12316  3656 RHHWNQSLLLKPREALDAAALEAALQALVEHHDALRLRFVEDAGGWTAEHLPVELGGALLWRAELDDAEELERLGEEAQR 3735

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1733 AMDPGTGSLLGTAVVN-GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEATTTRRIAHLLagQVHA 1811
Cdd:PRK12316  3736 SLDLADGPLLRALLATlADGSQRLLLVIHHLVVDGVSWRILLEDLQQAYQQLLQGEAPRLPAKTSSFKAWAERL--QEHA 3813

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1812 RA----REVDYWLEQLPerptsfGTSADRP-------LHRRRDESSLTYVVDDVAGSILTTVPQAFGSSVDDVLLGALAR 1880
Cdd:PRK12316  3814 RGealkAELAYWQEQLQ------GVSSELPcdhpqgaLQNRHAASVQTRLDRELTRRLLQQAPAAYRTQVNDLLLTALAR 3887

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1881 AVRAWqldNGIADggpVTVSTEGHGRDESIAGdegaIDLSRTVGWFTSITPLAVDASSDVVHAVKSAKDARLSRPAGGVG 1960
Cdd:PRK12316  3888 VVCRW---TGEAS---ALVQLEGHGREDLFAD----IDLSRTVGWFTSLFPVRLSPVEDLGASIKAIKEQLRAIPNKGIG 3957

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1961 FGILRYNSDGE----IAHRPLPTIMYNYFGGGTApSTETAPDDFLPVSDRpnmpssiTGAMRSP-SVFGINISTAGR-EE 2034
Cdd:PRK12316  3958 FGLLRYLGDEEsrrtLAGLPVPRITFNYLGQFDG-SFDEEMALFVPAGES-------AGAEQSPdAPLDNWLSLNGRvYG 4029

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2035 RRLEAKVTYATDALDEAAASDIARRWHDELRAVVELVDGGAEIGLSRADVPGVEVTQDDLD-LIAQQYPGADVWPMTPLQ 2113
Cdd:PRK12316  4030 GELSLDWTFSREMFEEATIQRLADDYAAELTALVEHCCDAERHGVTPSDFPLAGLDQARLDaLPLPLGEIEDIYPLSPMQ 4109

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2114 QGLFFqadlaNTVADHDAIDvYVTQTVLSLTGdVDPGRLRSALSELLARQRVLRSGFV-RLPSGAAVTVVPAEVTVPWSV 2192
Cdd:PRK12316  4110 QGMLF-----HSLYEQEAGD-YINQMRVDVQG-LDVERFRAAWQAALDRHDVLRSGFVwQGELGRPLQVVHKQVSLPFAE 4182

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2193 IDLRAedAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGA-ELVVTNHHLLIDGWSSPLVLADLLslyatgQTF 2271
Cdd:PRK12316  4183 LDWRG--RADLQAALDALAAAERERGFDLQRAPLLRLVLVRTAEGRhHLIYTNHHILMDGWSNSQLLGEVL------ERY 4254

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2272 TGSLPGTSGRDFADHARAVATADVEAGIAAWREVLAPVTEPTLVAPGHEPSADAPPR---DHQFSIDVKVTERLEALARN 2348
Cdd:PRK12316  4255 SGRPPAQPGGRYRDYIAWLQRQDAAASEAFWREQLAALDEPTRLAQAIARADLRSANgygEHVRELDATATARLREFART 4334

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2349 NSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVL 2428
Cdd:PRK12316  4335 QRVTLNTLVQAAWLLLLQRYTGQDTVAFGATVAGRPAELPGIEGQIGLFINTLPVIATPRAQQSVVEWLQQVQRQNLALR 4414

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2429 DHQQIGLPRLV--AQTGLPALFDTLAVYESFPVNvdsvAGIDASSAGGLKLVGAKTSDATHYPLNLSASrRGAELALKLK 2506
Cdd:PRK12316  4415 EHEHTPLYEIQrwAGQGGEALFDSLLVFENYPVS----EALQQGAPGGLRFGEVTNHEQTNYPLTLAVG-LGETLSLQFS 4489

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2507 YLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAE---AAVELTPVTGGPATDPVTLAELFRAAARRAPDHVA 2583
Cdd:PRK12316  4490 YDRGHFDAATIERLARHLTNLLEAMAEDPQRRLGELQLLEKAeqqRIVALWNRTDAGYPATRCVHQLVAERARMTPDAVA 4569

                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2584 VVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSG 2663
Cdd:PRK12316  4570 VVFD-EEKLTYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSG 4648

                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2664 AVLGLS-VLASGDLPgqefewmrldddsVAAEIAAVPAGPITDAERLGE------VTAANLAYVIYTSGSTGRPKGVAVT 2736
Cdd:PRK12316  4649 AALLLTqSHLLQRLP-------------IPDGLASLALDRDEDWEGFPAhdpavrLHPDNLAYVIYTSGSTGRPKGVAVS 4715

                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2737 HSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVL 2816
Cdd:PRK12316  4716 HGSLVNHLHATGERYELTPDDRVLQFMSFSFDGSHEGLYHPLINGASVVIRDDSLWDPERLYAEIHEHRVTVLVFPPVYL 4795

                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2817 STMDPTA-----VPSLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGITISSAmRPGDP-----VRLGGPIG 2883
Cdd:PRK12316  4796 QQLAEHAerdgePPSLRVYCFGGEAVAQASYDLAwraLKPVYLFNGYGPTETTVTVLLWKA-RDGDAcgaayMPIGTPLG 4874

                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2884 GVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTdtgglTLEYTG 2963
Cdd:PRK12316  4875 NRSGYVLDGQLNPLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGGRLYRTGDLARYRADG-----VIDYLG 4949

                         3050      3060      3070      3080      3090      3100      3110      3120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2964 RSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVE---------VSELKAFAGGRLPAY 3034
Cdd:PRK12316  4950 RVDHQVKIRGFRIELGEIEARLREHPAVREAVVIAQEGAVGKQLVGYVVPQDPALAdadeaqaelRDELKAALRERLPEY 5029

                         3130      3140      3150      3160      3170      3180      3190      3200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3035 MVPSSFTVIDELPLTPVGKLDKRALPEP--VLEAGEYVAPATGTERTIADVAAGVLNIDAglVSATSSFFELGGDSLSAA 3112
Cdd:PRK12316  5030 MVPAHLVFLARMPLTPNGKLDRKALPQPdaSLLQQAYVAPRSELEQQVAAIWAEVLQLER--VGLDDNFFELGGHSLLAI 5107

                         3210      3220      3230
                   ....*....|....*....|....*....|
gi 1827387616 3113 RLAARLSDQLGVAVSVRDVFESGSIRALAE 3142
Cdd:PRK12316  5108 QVTSRIQLELGLELPLRELFQTPTLAAFVE 5137

PRK05691

peptide synthase; Validated

4-3146

0e+00

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 1671.86 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvTSDGE 83
Cdd:PRK05691  1160 AELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSGVELLL-TQSHL 1238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDIVDVhvldisspgdaDLDEEEFAG-PTRPA-------NAAFTLFTSGSTGRPKAVVITHRGIANRLAADIE 155
Cdd:PRK05691  1239 LERLPQAEGVSAI-----------ALDSLHLDSwPSQAPglhlhgdNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQA 1307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  156 QYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFneVLGAGVG 235
Cdd:PRK05691  1308 TYALDDSDVLMQKAPISFDVSVWECFWPLITGCRLVLAGPGEHRDPQRIAELVQQYGVTTLHFVPPLLQLF--IDEPLAA 1385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  236 ELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD-RVIPIGTPTRRVSARVLDAALREVP 314
Cdd:PRK05691  1386 ACTSLRRLFSGGEALPAELRNRVLQRLPQVQLHNRYGPTETAINVTHWQCQAEDgERSPIGRPLGNVLCRVLDAELNLLP 1465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  315 IGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA 394
Cdd:PRK05691  1466 PGVAGELCIGGAGLARGYLGRPALTAERFVPDPLGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQA 1545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  395 ALAAAPGVLHAAAAVVDGPGGQQLVGYL---APADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEP 471
Cdd:PRK05691  1546 RLLAQPGVAQAAVLVREGAAGAQLVGYYtgeAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALPEP 1625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  472 EIAPTLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVRGLVHAV 551
Cdd:PRK05691  1626 VWQQREHVEPRTELQQQIAAIWREVLGLPRVGLRDDFFALGGHSLLATQIVSRTRQACDVELPLRALFEASELGAFAEQV 1705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  552 -----SGRGSALPSVKRIEpRPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRT 626
Cdd:PRK05691  1706 ariqaAGERNSQGAIARVD-RSQPVPLSYSQQRMWFLWQMEPDSPAYNVGGMARLSGVLDVDRFEAALQALILRHETLRT 1784

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  627 VYPSVGAAPVQDVlpVAVAREQLDWREADSVESLVRSTT----------EGFDVSTQMPLRGRFHRDGAGLH-VALTMHH 695
Cdd:PRK05691  1785 TFPSVDGVPVQQV--AEDSGLRMDWQDFSALPADARQQRlqqladseahQPFDLERGPLLRACLVKAAEREHyFVLTLHH 1862

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  696 IAMDGQSIPVLARDLMSAYAARAEGRTGGLPVLDVQYADYALWQQSVLgdaddETSVLGEQLSHWRRVLAGLPAVTDLPM 775
Cdd:PRK05691  1863 IVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQRQWL-----ESGERQRQLDYWKAQLGNEHPLLELPA 1937

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  776 DRPRPAVLGTAGATVTVEFDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMF 855
Cdd:PRK05691  1938 DRPRPPVQSHRGELYRFDLSPELAARVRAFNAQRGLTLFMTMTATLAALLYRYSGQRDLRIGAPVANRIRPESEGLIGAF 2017

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  856 VNTLLLRTQVDPGHSVGDLLGNVRTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQI-------AFTYTEptvndvag 928
Cdd:PRK05691  2018 LNTQVLRCQLDGQMSVSELLEQVRQTVIEGQSHQDLPFDHLVEALQPPRSAAYNPLFQVmcnvqrwEFQQSR-------- 2089

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  929 lEASGIQaapVDTGVVNA---KFDLTVAVRARSGgtPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDID 1005
Cdd:PRK05691  2090 -QLAGMT---VEYLVNDAratKFDLNLEVTDLDG--RLGCCLTYSRDLFDEPRIARMAEHWQNLLEALLGDPQQRLAELP 2163

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1006 IVGAARAKsvsapvsaRTPGAMVGRGGEVEAGTLIDVL--AQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGV 1083
Cdd:PRK05691  2164 LLAAAEQQ--------QLLDSLAGEAGEARLDQTLHGLfaAQAARTPQAPALTFAGQTLSYAELDARANRLARALRERGV 2235

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1084 SPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGE---SSCEWVdladL 1160
Cdd:PRK05691  2236 GPQVRVGLALERSLEMVVGLLAILKAGGAYVPLDPEYPLERLHYMIEDSGIGLLLSDRALFEALGElpaGVARWC----L 2311

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1161 EAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVdfVNSLAKITT-GTPEDEPDtriLHVASPSFD 1239
Cdd:PRK05691  2312 EDDAAALAAYSDAPLPFLSLPQHQAYLIYTSGSTGKPKGVVVSHGEIA--MHCQAVIERfGMRADDCE---LHFYSINFD 2386

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1240 ASMFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSvlatVDPERAQY---------VRNLATGGEACPP 1310
Cdd:PRK05691  2387 AASERLLVPLLCGARVVLRAQGQWGAEEICQLIREQQVSILGFTPS----YGSQLAQWlagqgeqlpVRMCITGGEALTG 2462

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1311 ELVERWSE--RGRRIFNCYGPTEATVW-----ATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGL 1383
Cdd:PRK05691  2463 EHLQRIRQafAPQLFFNAYGPTETVVMplaclAPEQLEEGAASVPIGRVVGARVAYILDADLALVPQGATGELYVGGAGL 2542

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1384 ARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVV 1463
Cdd:PRK05691  2543 AQGYHDRPGLTAERFVADPFAADGGRLYRTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLEHPAVREAVVL 2622

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1464 GVEsTRGGRkhtEVVAYLVAKPGATIDSA------AVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPephAPE 1537
Cdd:PRK05691  2623 ALD-TPSGK---QLAGYLVSAVAGQDDEAqaalreALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRALP---APD 2695

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1538 PA----EYVAPANPAEDNLARIVAGLLGEERVSVTESFFALGGDSIMSIQLSSAAKAAGIHLSPREIFELKTIRAMAAAA 1613
Cdd:PRK05691  2696 PElnrqAYQAPRSELEQQLAQIWREVLNVERVGLGDNFFELGGDSILSIQVVSRARQLGIHFSPRDLFQHQTVQTLAAVA 2775

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1614 AASGGPVAliEElpGGGTGEMPLPPVTSWMIEhsEEPADFADFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTR 1693
Cdd:PRK05691  2776 THSEAAQA--EQ--GPLQGASGLTPIQHWFFD--SPVPQPQHWNQALLLEPRQALDPALLEQALQALVEHHDALRLRFSQ 2849

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1694 SGDGWTMNAGAG------IVPAVREIDAEGALdpaLVDAHRELlgamDPGTGSLLGTAVVNG-EGRRRLVIAIHHLGVDA 1766
Cdd:PRK05691  2850 ADGRWQAEYRAVtaqellWQVTVADFAECAAL---FADAQRSL----DLQQGPLLRALLVDGpQGQQRLLLAIHHLVVDG 2922

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1767 VSWPILVEDLVTAWAQLTSGRPIELRPEATTTRRIAHLLAGQVHARA--REVDYWLEQLPERPTSFgtSADRPL--HRRR 1842
Cdd:PRK05691  2923 VSWRVLLEDLQALYRQLSAGAEPALPAKTSAFRDWAARLQAYAGSESlrEELGWWQAQLGGPRAEL--PCDRPQggNLNR 3000

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1843 DESSLTYVVD-DVAGSILTTVPQAFGSSVDDVLLGALARAVRAWQLDNGiadggpVTVSTEGHGRDesiaGDEGAIDLSR 1921
Cdd:PRK05691  3001 HAQTVSVRLDaERTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQPS------VLVQLEGHGRE----ALFDDIDLTR 3070

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1922 TVGWFTSITPL----AVDASSDVVHAVKSAKDARLSRPAGGVGFGILRYNSDG----EIAHRPLPTIMYNYFGggtAPST 1993
Cdd:PRK05691  3071 SVGWFTSAYPLrltpAPGDDAARGESIKAIKEQLRAVPHKGLGYGVLRYLADAavreAMAALPQAPITFNYLG---QFDQ 3147

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1994 ETAPDDFLPVSDRPNMPSSITGAmRSPSVFGINISTAGREerrLEAKVTYATDALDEAAASDIARRWHDELRAVVE--LV 2071
Cdd:PRK05691  3148 SFASDALFRPLDEPAGPAHDPDA-PLPNELSVDGQVYGGE---LVLRWTYSAERYDEQTIAELAEAYLAELQALIAhcLA 3223

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2072 DGGAeiGLSRADVPGVEVTQDDLDliAQQYPGA---DVWPMTPLQQGLFFQADLantvadHDAIDVYVTQTVLSLTGDVD 2148
Cdd:PRK05691  3224 DGAG--GLTPSDFPLAQLTQAQLD--ALPVPAAeieDVYPLTPMQEGLLLHTLL------EPGTGLYYMQDRYRINSALD 3293

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2149 PGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAEVTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIR 2228
Cdd:PRK05691  3294 PERFAQAWQAVVARHEALRASFSWNAGETMLQVIHKPGRTPIDYLDWRGLPEDGQEQRLQALHKQEREAGFDLLNQPPFH 3373

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2229 VVLVEHGDGAE-LVVTNHHLLIDGWSSPLVLADLLSLY-ATGQTFTGSLPgTSGRdFADHARAVATADVEAGIAAWREVL 2306
Cdd:PRK05691  3374 LRLIRVDEARYwFMMSNHHILIDAWCRSLLMNDFFEIYtALGEGREAQLP-VPPR-YRDYIGWLQRQDLAQARQWWQDNL 3451

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2307 APVTEPTLVapghePSADAPPRDHQFS------------IDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTV 2374
Cdd:PRK05691  3452 RGFERPTPI-----PSDRPFLREHAGDsggmvvgdcytrLDAADGARLRELAQAHQLTVNTFAQAAWALVLRRYSGDRDV 3526

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2375 TFAETVSGRSPDIEGMESMVGMFINTIPAVV---DVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLPA---LF 2448
Cdd:PRK05691  3527 LFGVTVAGRPVSMPQMQRTVGLFINSIALRVqlpAAGQRCSVRQWLQGLLDSNMELREYEYLPLVAIQECSELPKgqpLF 3606

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2449 DTLAVYESFPVNV---DSVAGIDASSAGGlklvgaKTSdaTHYPLNlSASRRGAELALKLKYLPTAFAPEQVAVFADVLT 2525
Cdd:PRK05691  3607 DSLFVFENAPVEVsvlDRAQSLNASSDSG------RTH--TNFPLT-AVCYPGDDLGLHLSYDQRYFDAPTVERLLGEFK 3677

                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2526 GLLGAIADHPEATCAEIPLLPAEAAVELTPVTGGPATD-PV--TLAELFRAAARRAPDHVaVVDGAGARLTYRELDEASD 2602
Cdd:PRK05691  3678 RLLLALVQGFHGDLSELPLLGEQERDFLLDGCNRSERDyPLeqSYVRLFEAQVAAHPQRI-AASCLDQQWSYAELNRAAN 3756

                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2603 RLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSG-------------AVLGLS 2669
Cdd:PRK05691  3757 RLGHALRAAGVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPLDPGLPAQRLQRIIELSRtpvlvcsaacreqARALLD 3836

                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2670 VLASGDLPgQEFEWMRLDDDSVAAEIAAVPAGPitdaerlgevtaANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESD 2749
Cdd:PRK05691  3837 ELGCANRP-RLLVWEEVQAGEVASHNPGIYSGP------------DNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVP 3903

                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2750 RLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSE-AVGGEVLERFIAEHGATHTFLTPSVLSTM---DPTAVP 2825
Cdd:PRK05691  3904 YLALSEADVIAQTASQSFDISVWQFLAAPLFGARVEIVPNAiAHDPQGLLAHVQAQGITVLESVPSLIQGMlaeDRQALD 3983

                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2826 SLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTIGIT---ISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPV 2899
Cdd:PRK05691  3984 GLRWMLPTGEAMPPELARQWLqryPQIGLVNAYGPAECSDDVAffrVDLASTRGSYLPIGSPTDNNRLYLLDEALELVPL 4063

                         3050      3060      3070      3080      3090      3100      3110      3120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2900 GMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDtdtgGLtLEYTGRSDDQVKLRGLRIELG 2979
Cdd:PRK05691  4064 GAVGELCVAGTGVGRGYVGDPLRTALAFVPHPFGAPGERLYRTGDLARRRSD----GV-LEYVGRIDHQVKIRGYRIELG 4138

                         3130      3140      3150      3160      3170      3180      3190      3200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2980 EIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEVSEL----KAFAGGRLPAYMVPSSFTVIDELPLTPVGKLD 3055
Cdd:PRK05691  4139 EIEARLHEQAEVREAAVAVQEGVNGKHLVGYLVPHQTVLAQGALleriKQRLRAELPDYMVPLHWLWLDRLPLNANGKLD 4218

                         3210      3220      3230      3240      3250      3260      3270      3280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3056 KRALPEP---VLEAGEYVAPATGTERTIADVAAGVLNIDAglVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVF 3132
Cdd:PRK05691  4219 RKALPALdigQLQSQAYLAPRNELEQTLATIWADVLKVER--VGVHDNFFELGGHSLLATQIASRVQKALQRNVPLRAMF 4296

                         3290
                   ....*....|....
gi 1827387616 3133 ESGSIRALAETVGG 3146
Cdd:PRK05691  4297 ECSTVEELAEYIEG 4310

PRK12316

peptide synthase; Provisional

569-3148

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 1613.10 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  569 ERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDV---LPVAVA 645
Cdd:PRK12316    48 ERDRLSYAQQRMWFLWQLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGADDSLAQVpldRPLEVE 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  646 REQLDW-----READSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARAE 719
Cdd:PRK12316   128 FEDCSGlpeaeQEARLRDEAQRESLQPFDLCEGPLLRVRLLRLGEEEHVlLLTLHHIVSDGWSMNVLIEEFSRFYSAYAT 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  720 GRTGGLPVLDVQYADYALWQQSVLGDADDEtsvlgEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLA 799
Cdd:PRK12316   208 GAEPGLPALPIQYADYALWQRSWLEAGEQE-----RQLEYWRAQLGEEHPVLELPTDHPRPAVPSYRGSRYEFSIDPALA 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  800 DRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVR 879
Cdd:PRK12316   283 EALRGTARRQGLTLFMLLLGAFNVLLHRYSGQTDIRVGVPIANRNRAEVEGLIGFFVNTQVLRSVFDGRTRVATLLAGVK 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  880 TTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYtEPTVNDVAGL-EASGIQAAPVDTGVVNAKFDLTVAVRARS 958
Cdd:PRK12316   363 DTVLGAQAHQDLPFERLVEALKVERSLSHSPLFQVMYNH-QPLVADIEALdTVAGLEFGQLEWKSRTTQFDLTLDTYEKG 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  959 GGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAARAKSVSAPVSArtpgamVGRGGEVEAGT 1038
Cdd:PRK12316   442 GR--LHAALTYATDLFEARTVERMARHWQNLLRGMVENPQARVDELPMLDAEERGQLVEGWNA------TAAEYPLQRGV 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1039 LIDVLAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDP 1118
Cdd:PRK12316   514 HRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDP 593

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1119 AYPADRIAYMLEDSGATVGITDASTRARLGESSCEWV---DLADLEAEAESgdditdtERNGSVRLT--NLAYLIYTSGS 1193
Cdd:PRK12316   594 EYPAERLAYMLEDSGVQLLLSQSHLGRKLPLAAGVQVldlDRPAAWLEGYS-------EENPGTELNpeNLAYVIYTSGS 666

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1194 TGRPKAVGVSHTGIvdfVNSLAKITTGTPEDEPDTrILHVASPSFDASMFEMAWAIPAGHTLVIAPQAD-FAGDALATVL 1272
Cdd:PRK12316   667 TGKPKGAGNRHRAL---SNRLCWMQQAYGLGVGDT-VLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDhRDPAKLVELI 742

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1273 ERDEVTDMIITPSVLATV----DPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATRS--RMTAG 1344
Cdd:PRK12316   743 NREGVDTLHFVPSMLQAFlqdeDVASCTSLRRIVCSGEALPADAQEQVFAKlpQAGLYNLYGPTEAAIDVTHWtcVEEGG 822

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 KPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEpGARMYATGDLVRVAKGGN 1424
Cdd:PRK12316   823 DSVPIGRPIANLACYILDANLEPVPVGVLGELYLAGRGLARGYHGRPGLTAERFVPSPFVA-GERMYRTGDLARYRADGV 901

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1425 LEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVEstrgGRkhtEVVAYLVAKpgatiDSAAVLDEA-AQHLA 1503
Cdd:PRK12316   902 IEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAVD----GK---QLVGYVVLE-----SEGGDWREAlKAHLA 969

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1504 AH----MVPSQAIVIDEIPLTPAGKLDRAALPEPHAPEP-AEYVAPANPAEDNLARIVAGLLGEERVSVTESFFALGGDS 1578
Cdd:PRK12316   970 ASlpeyMVPAQWLALERLPLTPNGKLDRKALPAPEASVAqQGYVAPRNALERTLAAIWQDVLGVERVGLDDNFFELGGDS 1049

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1579 IMSIQLSSAAKAAGIHLSPREIFELKTIRAMAAAAAAsgGPVALIEELPggGTGEMPLPPVTSWMIEhsEEPADFADFSQ 1658
Cdd:PRK12316  1050 IVSIQVVSRARQAGIQLSPRDLFQHQTIRSLALVAKA--GQATAADQGP--ASGEVALAPVQRWFFE--QAIPQRQHWNQ 1123

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1659 SLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTM---NAGAGIVPAVREIDAEGALDPALVDAHRELlgamD 1735
Cdd:PRK12316  1124 SLLLQARQPLDPDRLGRALERLVAHHDALRLRFREEDGGWQQayaAPQAGEVLWQRQAASEEELLALCEEAQRSL----D 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1736 PGTGSLLGTAVVN-GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPielrPEATTTRRIAHLLAGQVHARAR 1814
Cdd:PRK12316  1200 LEQGPLLRALLVDmADGSQRLLLVIHHLVVDGVSWRILLEDLQRAYADLDADLP----ARTSSYQAWARRLHEHAGARAE 1275

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1815 EVDYWLEQLPERPTSFgtSADRP---LHRRRDESSLTYVVDDVAGSILTTVPQAFGSSVDDVLLGALARAVRAWQLDngi 1891
Cdd:PRK12316  1276 ELDYWQAQLEDAPHEL--PCENPdgaLENRHERKLELRLDAERTRQLLQEAPAAYRTQVNDLLLTALARVTCRWSGQ--- 1350

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1892 adgGPVTVSTEGHGRDEsiAGDegAIDLSRTVGWFTSITPLAVDASSDVVHAVKSAKDARLSRPAGGVGFGILRYNSDGE 1971
Cdd:PRK12316  1351 ---ASVLVQLEGHGRED--LFE--DIDLSRTVGWFTSLFPVRLTPAADLGESIKAIKEQLRAVPDKGIGYGLLRYLAGEE 1423

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1972 IAHR----PLPTIMYNYFGGGTAPSTETAPddFLPVSDRpnmpssiTGAMRSPSV-----FGINISTAGREerrLEAKVT 2042
Cdd:PRK12316  1424 AAARlaalPQPRITFNYLGQFDRQFDEAAL--FVPATES-------AGAAQDPCAplanwLSIEGQVYGGE---LSLHWS 1491

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2043 YATDALDEAAASDIARRWHDELRAVVELVDGGAEIGLSRADVPGVEVTQDDLDLIAQQYPG-ADVWPMTPLQQGLFFqad 2121
Cdd:PRK12316  1492 FSREMFAEATVQRLADDYARELQALIEHCCDERNRGVTPSDFPLAGLSQAQLDALPLPAGEiADIYPLSPMQQGMLF--- 1568

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2122 laNTVADHDAIDvYVTQTVLSLTGdVDPGRLRSALSELLARQRVLRSGFVRLPSGA-AVTVVPAEVTVPWSVIDLRAEDa 2200
Cdd:PRK12316  1569 --HSLYEQEAGD-YINQLRVDVQG-LDPDRFRAAWQATVDRHEILRSGFLWQDGLEqPLQVIHKQVELPFAELDWRGRE- 1643

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2201 aSLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGA-ELVVTNHHLLIDGWSSPLVLADLLSLYAtgqtftGSLPGTS 2279
Cdd:PRK12316  1644 -DLGQALDALAQAERQKGFDLTRAPLLRLVLVRTGEGRhHLIYTNHHILMDGWSNAQLLGEVLQRYA------GQPVAAP 1716

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2280 GRDFADHARAVATADVEAGIAAWREVLAPVTEPTLVApgHEPSADAPPR---DHQFSIDVKVTERLEALARNNSTTMATV 2356
Cdd:PRK12316  1717 GGRYRDYIAWLQRQDAAASEAFWKEQLAALEEPTRLA--QAARTEDGQVgygDHQQLLDPAQTRALAEFARAQKVTLNTL 1794

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2357 VQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGL- 2435
Cdd:PRK12316  1795 VQAAWLLLLQRYTGQETVAFGATVAGRPAELPGIEQQIGLFINTLPVIAAPRPDQSVADWLQEVQALNLALREHEHTPLy 1874

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2436 --PRLVAQTGlPALFDTLAVYESFPVnvdsVAGIDASSAGGLKLVGAKTSDATHYPLNLsASRRGAELALKLKYLPTAFA 2513
Cdd:PRK12316  1875 diQRWAGQGG-EALFDSLLVFENYPV----AEALKQGAPAGLVFGRVSNHEQTNYPLTL-AVTLGETLSLQYSYDRGHFD 1948

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2514 PEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEAAVELTPV---TGGPATDPVTLAELFRAAARRAPDHVAVVDGaGA 2590
Cdd:PRK12316  1949 AAAIERLDRHLLHLLEQMAEDAQAALGELALLDAGERQRILADwdrTPEAYPRGPGVHQRIAEQAARAPEAIAVVFG-DQ 2027

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2591 RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLS- 2669
Cdd:PRK12316  2028 HLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTq 2107

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2670 --VLASGDLPgQEFEWMRLDDDsvaaeiAAVPAGPITDAERlgEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQE 2747
Cdd:PRK12316  2108 rhLLERLPLP-AGVARLPLDRD------AEWADYPDTAPAV--QLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAA 2178

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2748 SDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLSTMDPTA---- 2823
Cdd:PRK12316  2179 GERYELSPADCELQFMSFSFDGAHEQWFHPLLNGARVLIRDDELWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAerdg 2258

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2824 -VPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTIGITISSAmRPGDP-----VRLGGPIGGVDLMVLDERL 2894
Cdd:PRK12316  2259 rPPAVRVYCFGGEAVPAASLRLAWealRPVYLFNGYGPTEAVVTPLLWKC-RPQDPcgaayVPIGRALGNRRAYILDADL 2337

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2895 RPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGL 2974
Cdd:PRK12316  2338 NLLAPGMAGELYLGGEGLARGYLNRPGLTAERFVPDPFSASGERLYRTGDLARYRADG-----VVEYLGRIDHQVKIRGF 2412

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2975 RIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEV-SELKAFAGGRLPAYMVPSSFTVIDELPLTPVGK 3053
Cdd:PRK12316  2413 RIELGEIEARLQAHPAVREAVVVAQDGASGKQLVAYVVPDDAAEDLlAELRAWLAARLPAYMVPAHWVVLERLPLNPNGK 2492

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3054 LDKRALPEPVLEAGE--YVAPATGTERTIADVAAGVLNIDAglVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDV 3131
Cdd:PRK12316  2493 LDRKALPKPDVSQLRqaYVAPQEGLEQRLAAIWQAVLKVEQ--VGLDDHFFELGGHSLLATQVVSRVRQDLGLEVPLRIL 2570

                         2650
                   ....*....|....*..
gi 1827387616 3132 FESGSIRALAETVGGSE 3148
Cdd:PRK12316  2571 FERPTLAAFAASLESGQ 2587

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

563-1887

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 835.28 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  563 RIEPRPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPV 642
Cdd:COG1020     10 PPAAAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPV 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  643 AVAREQL--------DWREADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHVAL-TMHHIAMDGQSIPVLARDLMSA 713
Cdd:COG1020     90 VAAPLPVvvllvdleALAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLlALHHIISDGLSDGLLLAELLRL 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  714 YAARAEGRTGGLPVLDVQYADYALWQQsvlgdADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVE 793
Cdd:COG1020    170 YLAAYAGAPLPLPPLPIQYADYALWQR-----EWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRGARVSFR 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  794 FDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGD 873
Cdd:COG1020    245 LPAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRPELEGLVGFFVNTLPLRVDLSGDPSFAE 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  874 LLGNVRTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEptvNDVAGLEASGIQAAPVDTGVVNAKFDLTVA 953
Cdd:COG1020    325 LLARVRETLLAAYAHQDLPFERLVEELQPERDLSRNPLFQVMFVLQN---APADELELPGLTLEPLELDSGTAKFDLTLT 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  954 VRARSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAA-RAKSVSAPVSARTPGAmvgrgg 1032
Cdd:COG1020    402 VVETGDG--LRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAeRQQLLAEWNATAAPYP------ 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1033 evEAGTLID-VLAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGA 1111
Cdd:COG1020    474 --ADATLHElFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGA 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1112 AYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGDDitdteRNGSVRLTNLAYLIYTS 1191
Cdd:COG1020    552 AYVPLDPAYPAERLAYMLEDAGARLVLTQSALAARLPELGVPVLALDALALAAEPATN-----PPVPVTPDDLAYVIYTS 626

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1192 GSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFA-GDALAT 1270
Cdd:COG1020    627 GSTGRPKGVMVEHRALVNLLAWMQRRYGLGPGD----RVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRdPAALAE 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1271 VLERDEVTDMIITPSVLATV---DPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRMTA-- 1343
Cdd:COG1020    703 LLARHRVTVLNLTPSLLRALldaAPEALPSLRLVLVGGEALPPELVRRWRARlpGARLVNLYGPTETTVDSTYYEVTPpd 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 --GKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAK 1421
Cdd:COG1020    783 adGGSVPIGRPIANTRVYVLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWLP 862

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1422 GGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQH 1501
Cdd:COG1020    863 DGNLEFLGRADDQVKIRGFRIELGEIEAALLQHPGVREAVVVAREDAPGDK---RLVAYVVPEAGAAAAAALLRLALALL 939

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1502 LAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPEPAEYVAPANPAEDNLARIVAGLLGEERVSVTESFFALGGDSIMS 1581
Cdd:COG1020    940 LPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLL 1019

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1582 IQLSSAAKAAGIHLSPREIFELKTIRAMAAAAAASGGPVALIEELPGGGtgemPLPPVTSWMIEHSEEPADFADFSQSLV 1661
Cdd:COG1020   1020 LLALARAARLLLLLLLLLLLFLAAAAAAAAAAAAAAAAAAAAPLAAAAA----PLPLPPLLLSLLALLLALLLLLALLAL 1095

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1662 FNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTMNAGAGIVPAVREIDAEGALDPALVDAHRELLGAM------- 1734
Cdd:COG1020   1096 LALLLLLLLLLLLLALLLLLALLLALLAALRARRAVRQEGPRLRLLVALAAALALAALLALLLAAAAAAAELLaaaalll 1175

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1735 -DPGTGSLLGTAVVNGEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEATTTRRIAHLLAGQVHARA 1813
Cdd:COG1020   1176 lLALLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAAL 1255

                         1290      1300      1310      1320      1330      1340      1350
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 1814 REVDYWLEQLPERPTSFGTSADRPLHRRRDESSLTYVVDDVAGSILTTVPQAFGSSVDDVLLGALARAVRAWQL 1887
Cdd:COG1020   1256 AAALLALALALLALALLLLALALLLPALARARAARTARALALLLLLALLLLLALALALLLLLLLLLALLLLALL 1329

PRK12467

peptide synthase; Provisional

568-1845

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 803.22 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  568 PERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDV---LPVAV 644
Cdd:PRK12467    47 FERIPLSYAQERQWFLWQLDPDSAAYNIPTALRLRGELDVSALRRAFDALVARHESLRTRFVQDEEGFRQVIdasLSLTI 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  645 AREQLDWREADSVESLVRSTTEG-----FDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARA 718
Cdd:PRK12467   127 PLDDLANEQGRARESQIEAYINEevarpFDLANGPLLRVRLLRLADDEHVlVVTLHHIISDGWSMRVLVEELVQLYSAYS 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  719 EGRTGGLPVLDVQYADYALWQQSVLGDADDEtsvlgEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDL 798
Cdd:PRK12467   207 QGREPSLPALPIQYADYAIWQRSWLEAGERE-----RQLAYWQEQLGGEHTVLELPTDRPRPAVPSYRGARLRVDLPQAL 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  799 ADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNV 878
Cdd:PRK12467   282 SAGLKALAQREGVTLFMVLLASFQTLLHRYSGQSDIRIGVPNANRNRVETERLIGFFVNTQVLKAEVDPQASFLELLQQV 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  879 RTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTY--TEPTVNDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRA 956
Cdd:PRK12467   362 KRTALGAQAHQDLPFEQLVEALQPERSLSHSPLFQVMFNHqnTATGGRDREGAQLPGLTVEELSWARHTAQFDLALDTYE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  957 RSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAArakSVSAPVSARTPGAMVGRGGEVEA 1036
Cdd:PRK12467   442 SAQG--LWAAFTYATDLFEATTIERLATHWRNLLEAIVAEPRRRLGELPLLDAE---ERARELVRWNAPATEYAPDCVHQ 516

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1037 gtLIDvlAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPV 1116
Cdd:PRK12467   517 --LIE--AQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPL 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1117 DPAYPADRIAYMLEDSGATVGITDASTRARLG-ESSCEWVDLADLEAEAESgdditDTERNGSVRLT--NLAYLIYTSGS 1193
Cdd:PRK12467   593 DPEYPQDRLAYMLDDSGVRLLLTQSHLLAQLPvPAGLRSLCLDEPADLLCG-----YSGHNPEVALDpdNLAYVIYTSGS 667

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1194 TGRPKAVGVSHTGIVDFVNSLAKittgTPEDEPDTRILHVASPSFDASMFEMAWAIPAGHTLVIAP-QADFAGDALATVL 1272
Cdd:PRK12467   668 TGQPKGVAISHGALANYVCVIAE----RLQLAADDSMLMVSTFAFDLGVTELFGALASGATLHLLPpDCARDAEAFAALM 743

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1273 ERDEVTDMIITPSVL------ATVDPERAQyvRNLATGGEACPPELVERWSERGR--RIFNCYGPTEATVWATRSRMT-- 1342
Cdd:PRK12467   744 ADQGVTVLKIVPSHLqallqaSRVALPRPQ--RALVCGGEALQVDLLARVRALGPgaRLINHYGPTETTVGVSTYELSde 821

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1343 --AGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVA 1420
Cdd:PRK12467   822 erDFGNVPIGQPLANLGLYILDHYLNPVPVGVVGELYIGGAGLARGYHRRPALTAERFVPDPFGADGGRLYRTGDLARYR 901

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1421 KGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVestrGGRKHTEVVAYLVakPGATIDSA---AVLDE 1497
Cdd:PRK12467   902 ADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVREAVVLAQ----PGDAGLQLVAYLV--PAAVADGAehqATRDE 975

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1498 AAQHLAA----HMVPSQAIVIDEIPLTPAGKLDRAALPEPHA-PEPAEYVAPANPAEDNLARIVAGLLGEERVSVTESFF 1572
Cdd:PRK12467   976 LKAQLRQvlpdYMVPAHLLLLDSLPLTPNGKLDRKALPKPDAsAVQATFVAPQTELEKRLAAIWADVLKVERVGLTDNFF 1055

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1573 ALGGDSIMSIQ-LSSAAKAAGIHLSPREIFELKTIRAMAAaaaasggpvALIEELPGGGTgemPLPPVTswmiEHSEEPA 1651
Cdd:PRK12467  1056 ELGGHSLLATQvISRVRQRLGIQVPLRTLFEHQTLAGFAQ---------AVAAQQQGAQP---ALPDVD----RDQPLPL 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1652 DFADFSQSLVFNV-PASAA--------------VADLQTVVEAVAAAHPMLTAVLtRSGDGWTMNA--GAGIVP-AVREI 1713
Cdd:PRK12467  1120 SYAQERQWFLWQLePGSAAyhipqalrlkgpldIEALERSFDALVARHESLRTTF-VQEDGRTRQVihPVGSLTlEEPLL 1198

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1714 DAEGALDPAL-VDAHRELLGAMDPGTGSLLGTAVVN-GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGR---- 1787
Cdd:PRK12467  1199 LAADKDEAQLkVYVEAEARQPFDLEQGPLLRVGLLRlAADEHVLVLTLHHIVSDGWSMQVLVDELVALYAAYSQGQslql 1278

                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1788 ---PIELRPEATTTRRiaHLLAGQvhaRAREVDYWLEQLPERPTSFGTSADRPlhRRRDES 1845
Cdd:PRK12467  1279 palPIQYADYAVWQRQ--WMDAGE---RARQLAYWKAQLGGEQPVLELPTDRP--RPAVQS 1332

PRK05691

peptide synthase; Validated

112-1837

0e+00

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 710.40 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  112 EEFAGPTRPANA-AFTLFTSGSTGRPKAVVITHRG-IANRLAadIEQ---YDLTARDVFLYKAPITFDVS-VREIFLPIA 185
Cdd:PRK05691   156 EAWQEPALQPDDiAFLQYTSGSTALPKGVQVSHGNlVANEQL--IRHgfgIDLNPDDVIVSWLPLYHDMGlIGGLLQPIF 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  186 IGATLVIAEPGRH-GDPVHLADLIRRHGVTVI---HFVPAMLAA-FNEVLGAGVgELTSLRLIQTGGEaltpPVARDLMV 260
Cdd:PRK05691   234 SGVPCVLMSPAYFlERPLRWLEAISEYGGTISggpDFAYRLCSErVSESALERL-DLSRWRVAYSGSE----PIRQDSLE 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  261 RLP------GTRLQN---QYGPAEASIVVTIHRVTQD-------------DRVIP--------IGTPTRRVSARVLDAA- 309
Cdd:PRK05691   309 RFAekfaacGFDPDSffaSYGLAEATLFVSGGRRGQGipaleldaealarNRAEPgtgsvlmsCGRSQPGHAVLIVDPQs 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  310 LREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVAdpfgEPGARLYRTGDRArWNRDGEIEYLGRTDFQVKLRGQRLEL 389
Cdd:PRK05691   389 LEVLGDNRVGEIWASGPSIAHGYWRNPEASAKTFVE----HDGRTWLRTGDLG-FLRDGELFVTGRLKDMLIVRGHNLYP 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  390 GEVEAALAAAPGVLH----AAAAVVDGpgGQQLVGYLA----------PADVDVDTVAATTAELLPEymRPSAWVRLD-- 453
Cdd:PRK05691   464 QDIEKTVEREVEVVRkgrvAAFAVNHQ--GEEGIGIAAeisrsvqkilPPQALIKSIRQAVAEACQE--APSVVLLLNpg 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  454 AMPLSRSGKVDRR---------------LLPEPEIAPTLYVP-PGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLS 517
Cdd:PRK05691   540 ALPKTSSGKLQRSacrlrladgsldsyaLFPALQAVEAAQTAaSGDELQARIAAIWCEQLKVEQVAADDHFFLLGGNSIA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  518 AARIAARVSKELGVDVSVRDVFESPSVRGLVHAVS----GRGSALPSVKRIePRPERLPLSRAQRRMWFLNQFDTASGAY 593
Cdd:PRK05691   620 ATQVVARLRDELGIDLNLRQLFEAPTLAAFSAAVArqlaGGGAAQAAIARL-PRGQALPQSLAQNRLWLLWQLDPQSAAY 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  594 NIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLP---VAVAREQLDWREADSVESLVRSTTEG--- 667
Cdd:PRK05691   699 NIPGGLHLRGELDEAALRASFQRLVERHESLRTRFYERDGVALQRIDAqgeFALQRIDLSDLPEAEREARAAQIREEear 778

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  668 --FDVSTQMPLRGRFHRDGAGLHVAL-TMHHIAMDGQSIPVLARDLMSAYAARAEGRTGGLPVLDVQYADYALWQQSVLG 744
Cdd:PRK05691   779 qpFDLEKGPLLRVTLVRLDDEEHQLLvTLHHIVADGWSLNILLDEFSRLYAAACQGQTAELAPLPLGYADYGAWQRQWLA 858

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  745 DADDEtsvlgEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRVDVLARSNTMTGFMVTEAAFAAT 824
Cdd:PRK05691   859 QGEAA-----RQLAYWKAQLGDEQPVLELATDHPRSARQAHSAARYSLRVDASLSEALRGLAQAHQATLFMVLLAAFQAL 933

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  825 VARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTTVLDAFANDQVQFDELIEALAPER 904
Cdd:PRK05691   934 LHRYSGQGDIRIGVPNANRPRLETQGLVGFFINTQVLRAQLDGRLPFTALLAQVRQATLGAQAHQDLPFEQLVEALPQAR 1013

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  905 sssHQPLAQIAFTYTEptvNDVAGLEA-SGIQAAPVDTGVVNAKFDLTV-AVRARSGGTPMAADfiYATDLFDESTVKRF 982
Cdd:PRK05691  1014 ---EQGLFQVMFNHQQ---RDLSALRRlPGLLAEELPWHSREAKFDLQLhSEEDRNGRLTLSFD--YAAELFDAATIERL 1085

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  983 AEVYRRVLQAIVDDQNTAVGDIDIVGAARAKSVSAPVSARTPGAMVgrggeveagTLIDVL-AQRDLDPDHPALICDGTE 1061
Cdd:PRK05691  1086 AEHFLALLEQVCEDPQRALGDVQLLDAAERAQLAQWGQAPCAPAQA---------WLPELLnEQARQTPERIALVWDGGS 1156

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1062 MDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDA 1141
Cdd:PRK05691  1157 LDYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSGVELLLTQS 1236

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1142 STRARLGESS-CEWVDLADLEAeaesgDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDfvnSLAKITTG 1220
Cdd:PRK05691  1237 HLLERLPQAEgVSAIALDSLHL-----DSWPSQAPGLHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAE---RLQWMQAT 1308

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1221 TPEDEPDTrILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDA-LATVLERDEVTDMIITPSVLAT-VDPERAQ-- 1296
Cdd:PRK05691  1309 YALDDSDV-LMQKAPISFDVSVWECFWPLITGCRLVLAGPGEHRDPQrIAELVQQYGVTTLHFVPPLLQLfIDEPLAAac 1387

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1297 -YVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWAT--RSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQG 1371
Cdd:PRK05691  1388 tSLRRLFSGGEALPAELRNRVLQRlpQVQLHNRYGPTETAINVThwQCQAEDGERSPIGRPLGNVLCRVLDAELNLLPPG 1467

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1372 VVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVL 1451
Cdd:PRK05691  1468 VAGELCIGGAGLARGYLGRPALTAERFVPDPLGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARL 1547

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1452 DAQPGVAQSVVVGVESTRGGRkhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALP 1531
Cdd:PRK05691  1548 LAQPGVAQAAVLVREGAAGAQ----LVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALP 1623

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1532 EPHApEPAEYVAPANPAEDNLARIVAGLLGEERVSVTESFFALGGDSIMSIQL-SSAAKAAGIHLSPREIF---ELKTIR 1607
Cdd:PRK05691  1624 EPVW-QQREHVEPRTELQQQIAAIWREVLGLPRVGLRDDFFALGGHSLLATQIvSRTRQACDVELPLRALFeasELGAFA 1702

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1608 AMAAAAAASG-----GPVALIEElpgggtgEMPLPPVTS----WMIEHSEepadfadfSQSLVFNVpasAAVADLQTVVE 1678
Cdd:PRK05691  1703 EQVARIQAAGernsqGAIARVDR-------SQPVPLSYSqqrmWFLWQME--------PDSPAYNV---GGMARLSGVLD 1764

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1679 aVAAAHPMLTAVLTRSGDGWTMNAGAGIVPaVREIDAEG----------ALDPALVDAHRELLG------AMDPGTGSLL 1742
Cdd:PRK05691  1765 -VDRFEAALQALILRHETLRTTFPSVDGVP-VQQVAEDSglrmdwqdfsALPADARQQRLQQLAdseahqPFDLERGPLL 1842

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1743 GTAVVN-GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEATT-------TRRiaHLLAGQvhaRAR 1814
Cdd:PRK05691  1843 RACLVKaAEREHYFVLTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQyldysvwQRQ--WLESGE---RQR 1917

                         1850      1860
                   ....*....|....*....|...
gi 1827387616 1815 EVDYWLEQLPERPTSFGTSADRP 1837
Cdd:PRK05691  1918 QLDYWKAQLGNEHPLLELPADRP 1940

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

2097-3148

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 710.09 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2097 IAQQYPGADVWPMTPLQQGLFFQADLANTVADHDAIDVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSG 2176
Cdd:COG1020      1 AAAAAAAALPPAAAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2177 AAVTVVPAEVTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDG-AELVVTNHHLLIDGWSSP 2255
Cdd:COG1020     81 RPVQVIQPVVAAPLPVVVLLVDLEALAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLlLLLLLALHHIISDGLSDG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2256 LVLADLLSLYATGQTFTGS----LPGTSGRDFADHARAVATADVEAGIAAWREVLAPVTEPTLVAPGHEPSADAPPR--D 2329
Cdd:COG1020    161 LLLAELLRLYLAAYAGAPLplppLPIQYADYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRgaR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2330 HQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPdiEGMESMVGMFINTIPAVVDVNP 2409
Cdd:COG1020    241 VSFRLPAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPR--PELEGLVGFFVNTLPLRVDLSG 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2410 DATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLP------ALFDTLAVYESFPVNVDSVAGIDASSAGGlklvgakTS 2483
Cdd:COG1020    319 DPSFAELLARVRETLLAAYAHQDLPFERLVEELQPErdlsrnPLFQVMFVLQNAPADELELPGLTLEPLEL-------DS 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2484 DATHYPLNLSASRRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEAAVELTPVTGGPATD 2563
Cdd:COG1020    392 GTAKFDLTLTVVETGDGLRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQQLLAEWNATAAP 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 ---PVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTG 2640
Cdd:COG1020    472 ypaDATLHELFEAQAARTPDAVAVVFG-DQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAG 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2641 GAYVPIDPDYPAERVASMIEDSGAVLGLSVLASGD-LPGQEFEWMRLDDDSVAAEIAAVPAGPitdaerlgeVTAANLAY 2719
Cdd:COG1020    551 AAYVPLDPAYPAERLAYMLEDAGARLVLTQSALAArLPELGVPVLALDALALAAEPATNPPVP---------VTPDDLAY 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAV-GGEVLE 2798
Cdd:COG1020    622 VIYTSGSTGRPKGVMVEHRALVNLLAWMQRRYGLGPGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARrDPAALA 701

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2799 RFIAEHGATHTFLTPSVLSTM---DPTAVPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTIGIT---ISSA 2869
Cdd:COG1020    702 ELLARHRVTVLNLTPSLLRALldaAPEALPSLRLVLVGGEALPPELVRRWRarlPGARLVNLYGPTETTVDSTyyeVTPP 781

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2870 MRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWT 2949
Cdd:COG1020    782 DADGGSVPIGRPIANTRVYVLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWL 861

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2950 PDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG-GSVATALAAYIVPVDGA-VEVSELKAFA 3027
Cdd:COG1020    862 PDG-----NLEFLGRADDQVKIRGFRIELGEIEAALLQHPGVREAVVVAREdAPGDKRLVAYVVPEAGAaAAAALLRLAL 936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3028 GGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGEYVAPATGTERTIADVAAGVLNIDAGLVSATSSFFELGGD 3107
Cdd:COG1020    937 ALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLG 1016

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|.
gi 1827387616 3108 SLSAARLAARLSDQLGVAVSVRDVFESGSIRALAETVGGSE 3148
Cdd:COG1020   1017 LLLLLALARAARLLLLLLLLLLLFLAAAAAAAAAAAAAAAA 1057

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

1-820

5.51e-178

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 587.98 E-value: 5.51e-178

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:COG1020    502 LTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYMLEDAGARLVLTQS 581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRfddivDVHVLDISSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:COG1020    582 ALAARLPEL-----GVPVLALDALALAAEPATNPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWMQRRYGLG 656

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFnevLGAGVGELTSL 240
Cdd:COG1020    657 PGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRAL---LDAAPEALPSL 733

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD---RVIPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:COG1020    734 RLVLVGGEALPPELVRRWRARLPGARLVNLYGPTETTVDSTYYEVTPPDadgGSVPIGRPIANTRVYVLDAHLQPVPVGV 813

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA 397
Cdd:COG1020    814 PGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWLPDGNLEFLGRADDQVKIRGFRIELGEIEAALL 893

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  398 AAPGVLHAAAAVV-DGPGGQQLVGYLAPADVDVDTVAATT---AELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEI 473
Cdd:COG1020    894 QHPGVREAVVVAReDAPGDKRLVAYVVPEAGAAAAAALLRlalALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAA 973

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  474 APTL-YVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVRGLVHAVS 552
Cdd:COG1020    974 AAAAaAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLLLLFLAAAAAAAAAAAA 1053

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  553 GRGSALPSVKRIEPRPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVG 632
Cdd:COG1020   1054 AAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLALLLALLAALRARRAVRQ 1133

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  633 AAPVQDVLPVAVA-------REQLDWREADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHVALTMHHIAMDGQSIPV 705
Cdd:COG1020   1134 EGPRLRLLVALAAalalaalLALLLAAAAAAAELLAAAALLLLLALLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 1213

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  706 LARDLMSAYAARAEGRTGGLPVLDVQYADYALWQQSVLGDADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGT 785
Cdd:COG1020   1214 LLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALALALLALALLLLALALLLPALARARAARTAR 1293

                          810       820       830
                   ....*....|....*....|....*....|....*
gi 1827387616  786 AGATVTVEFDDDLADRVDVLARSNTMTGFMVTEAA 820
Cdd:COG1020   1294 ALALLLLLALLLLLALALALLLLLLLLLALLLLAL 1328

LCL_NRPS-like

cd19540

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

570-996

4.25e-166

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 520.06 E-value: 4.25e-166

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVAVAREQL 649
Cdd:cd19540      1 RIPLSFAQQRLWFLNRLDGPSAAYNIPLALRLTGALDVDALRAALADVVARHESLRTVFPEDDGGPYQVVLPAAEARPDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  650 DWR---EADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARAEGRTGGL 725
Cdd:cd19540     81 TVVdvtEDELAARLAEAARRGFDLTAELPLRARLFRLGPDEHVlVLVVHHIAADGWSMAPLARDLATAYAARRAGRAPDW 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  726 PVLDVQYADYALWQQSVLGDADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRVDVL 805
Cdd:cd19540    161 APLPVQYADYALWQRELLGDEDDPDSLAARQLAYWRETLAGLPEELELPTDRPRPAVASYRGGTVEFTIDAELHARLAAL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  806 ARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTTVLDA 885
Cdd:cd19540    241 AREHGATLFMVLHAALAVLLSRLGAGDDIPIGTPVAGRGDEALDDLVGMFVNTLVLRTDVSGDPTFAELLARVRETDLAA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  886 FANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEptvNDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRARSG--GTP- 962
Cdd:cd19540    321 FAHQDVPFERLVEALNPPRSTARHPLFQVMLAFQN---TAAATLELPGLTVEPVPVDTGVAKFDLSFTLTERRDadGAPa 397

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1827387616  963 -MAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19540    398 gLTGELEYATDLFDRSTAERLADRFVRVLEAVVAD 432

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

2-468

6.80e-166

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 521.84 E-value: 6.80e-166

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTSD 81
Cdd:cd17646     25 TYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPGYPADRLAYMLADAGPA-VVLTTA 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEARSRFDDIVDVHVLDISSPGDADLDEeefagPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTA 161
Cdd:cd17646    104 DLAARLPAGGDVALLGDEALAAPPATPPLV-----PPRPDNLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEYPLGP 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  162 RDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVlgAGVGELTSLR 241
Cdd:cd17646    179 GDRVLQKTPLSFDVSVWELFWPLVAGARLVVARPGGHRDPAYLAALIREHGVTTCHFVPSMLRVFLAE--PAAGSCASLR 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  242 LIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEASIVVTIHRVT--QDDRVIPIGTPTRRVSARVLDAALREVPIGVPG 319
Cdd:cd17646    257 RVFCSGEALPPELAARFL-ALPGAELHNLYGPTEAAIDVTHWPVRgpAETPSVPIGRPVPNTRLYVLDDALRPVPVGVPG 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  320 ELYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA 399
Cdd:cd17646    336 ELYLGGVQLARGYLGRPALTAERFVPDPFG-PGSRMYRTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAH 414

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  400 PGVLHAAAAVVDGP-GGQQLVGYLAPA----DVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd17646    415 PAVTHAVVVARAAPaGAARLVGYVVPAagaaGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

2579-3059

4.80e-164

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 514.77 E-value: 4.80e-164

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd05930      1 PDAVAVVDG-DQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLglsVLasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgeVTAANLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd05930     80 LEDSGAKL---VL----------------------------------------TDPDDLAYVIYTSGSTGKPKGVMVEHR 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVG-GEVLERFIAEHGATHTFLTPS--- 2814
Cdd:cd05930    117 GLVNLLLWMQEAYPLTPGDRVLQFTSFSFDVSVWEIFGALLAGATLVVLPEEVRKdPEALADLLAEEGITVLHLTPSllr 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2815 -VLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTIGIT---ISSAMRPGDPVRLGGPIGGVDL 2887
Cdd:cd05930    197 lLLQELELAALPSLRLVLVGGEALPPDLVRRWRellPGARLVNLYGPTEATVDATyyrVPPDDEEDGRVPIGRPIPNTRV 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2888 MVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGtAGQRMYRTGDVVRWTPDtdtGglTLEYTGRSDD 2967
Cdd:cd05930    277 YVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFG-PGERMYRTGDLVRWLPD---G--NLEFLGRIDD 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2968 QVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATA-LAAYIVP-VDGAVEVSELKAFAGGRLPAYMVPSSFTVIDE 3045
Cdd:cd05930    351 QVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEKrLVAYVVPdEGGELDEEELRAHLAERLPDYMVPSAFVVLDA 430

                          490
                   ....*....|....
gi 1827387616 3046 LPLTPVGKLDKRAL 3059
Cdd:cd05930    431 LPLTPNGKVDRKAL 444

PRK12467

peptide synthase; Provisional

2135-3145

9.09e-164

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 572.49 E-value: 9.09e-164

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2135 YVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAaVTVVPAEVTVPWSVIDLRAEDAASLDSRVEEVLATE 2214
Cdd:PRK12467    72 YNIPTALRLRGELDVSALRRAFDALVARHESLRTRFVQDEEGF-RQVIDASLSLTIPLDDLANEQGRARESQIEAYINEE 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2215 RTNPFDMAKPPLIRVVLVEHGDGAE-LVVTNHHLLIDGWSSPLVLADLLSLYAT-GQTFTGSLPG--TSGRDFADHARAV 2290
Cdd:PRK12467   151 VARPFDLANGPLLRVRLLRLADDEHvLVVTLHHIISDGWSMRVLVEELVQLYSAySQGREPSLPAlpIQYADYAIWQRSW 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2291 ATA-DVEAGIAAWREVLAPvTEPTLVAPGHEPSADAPP---RDHQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLS 2366
Cdd:PRK12467   231 LEAgERERQLAYWQEQLGG-EHTVLELPTDRPRPAVPSyrgARLRVDLPQALSAGLKALAQREGVTLFMVLLASFQTLLH 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2367 RLTGTRTVTFAETVSGRSPdiEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVA------ 2440
Cdd:PRK12467   310 RYSGQSDIRIGVPNANRNR--VETERLIGFFVNTQVLKAEVDPQASFLELLQQVKRTALGAQAHQDLPFEQLVEalqper 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2441 QTGLPALFDTLavyesFPVNVDSVAGID--ASSAGGLKLVGAKT-SDATHYPLNLSASRRGAELALKLKYLPTAFAPEQV 2517
Cdd:PRK12467   388 SLSHSPLFQVM-----FNHQNTATGGRDreGAQLPGLTVEELSWaRHTAQFDLALDTYESAQGLWAAFTYATDLFEATTI 462

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2518 AVFADVLTGLLGAIADHPEATCAEIPLLPAEAAVELTPVTGGPATD--PVTLAELFRAAARRAPDHVAVVDGaGARLTYR 2595
Cdd:PRK12467   463 ERLATHWRNLLEAIVAEPRRRLGELPLLDAEERARELVRWNAPATEyaPDCVHQLIEAQARQHPERPALVFG-EQVLSYA 541

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2596 ELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLS---VLA 2672
Cdd:PRK12467   542 ELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEYPQDRLAYMLDDSGVRLLLTqshLLA 621

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2673 SGDLPgqefewmrldddsvaaeiAAVPAGPITDAERLGEVTAA----------NLAYVIYTSGSTGRPKGVAVTHSGLAN 2742
Cdd:PRK12467   622 QLPVP------------------AGLRSLCLDEPADLLCGYSGhnpevaldpdNLAYVIYTSGSTGQPKGVAISHGALAN 683

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2743 FARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAV-GGEVLERFIAEHGATHTFLTPSVLSTM-- 2819
Cdd:PRK12467   684 YVCVIAERLQLAADDSMLMVSTFAFDLGVTELFGALASGATLHLLPPDCArDAEAFAALMADQGVTVLKIVPSHLQALlq 763

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2820 DPTAVP--SLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGIT---ISSAMRPGDPVRLGGPIGGVDLMVLD 2891
Cdd:PRK12467   764 ASRVALprPQRALVCGGEALQVDLLARVralGPGARLINHYGPTETTVGVStyeLSDEERDFGNVPIGQPLANLGLYILD 843

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2892 ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDtdtGGltLEYTGRSDDQVKL 2971
Cdd:PRK12467   844 HYLNPVPVGVVGELYIGGAGLARGYHRRPALTAERFVPDPFGADGGRLYRTGDLARYRAD---GV--IEYLGRMDHQVKI 918

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2972 RGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGA------VEVSELKAFAGGRLPAYMVPSSFTVIDE 3045
Cdd:PRK12467   919 RGFRIELGEIEARLLAQPGVREAVVLAQPGDAGLQLVAYLVPAAVAdgaehqATRDELKAQLRQVLPDYMVPAHLLLLDS 998

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3046 LPLTPVGKLDKRALPEPVLEAGE--YVAPATGTERTIADVAAGVLniDAGLVSATSSFFELGGDSLSAARLAARLSDQLG 3123
Cdd:PRK12467   999 LPLTPNGKLDRKALPKPDASAVQatFVAPQTELEKRLAAIWADVL--KVERVGLTDNFFELGGHSLLATQVISRVRQRLG 1076

                         1050      1060
                   ....*....|....*....|..
gi 1827387616 3124 VAVSVRDVFESGSIRALAETVG 3145
Cdd:PRK12467  1077 IQVPLRTLFEHQTLAGFAQAVA 1098

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

4-468

1.10e-162

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 510.92 E-value: 1.10e-162

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtsdge 83
Cdd:cd05930     16 AELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYILEDSGAKLVL------ 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05930     90 ----------------------------------TDPDDLAYVIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAYPLTPGD 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAgvGELTSLRLI 243
Cdd:cd05930    136 RVLQFTSFSFDVSVWEIFGALLAGATLVVLPEEVRKDPEALADLLAEEGITVLHLTPSLLRLLLQELEL--AALPSLRLV 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  244 QTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD---RVIPIGTPTRRVSARVLDAALREVPIGVPGE 320
Cdd:cd05930    214 LVGGEALPPDLVRRWRELLPGARLVNLYGPTEATVDATYYRVPPDDeedGRVPIGRPIPNTRVYVLDENLRPVPPGVPGE 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  321 LYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAP 400
Cdd:cd05930    294 LYIGGAGLARGYLNRPELTAERFVPNPFG-PGERMYRTGDLVRWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHP 372

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  401 GVLHAAA-AVVDGPGGQQLVGYLAPADVDVDTVAATTAEL---LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05930    373 GVREAAVvAREDGDGEKRLVAYVVPDEGGELDEEELRAHLaerLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

1050-1530

7.75e-162

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 508.22 E-value: 7.75e-162

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd05930      1 PDAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAStrarlgesscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd05930     81 EDSGAKLVLTDPD----------------------------------------DLAYVIYTSGSTGKPKGVMVEHRGLVN 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQAD-FAGDALATVLERDEVTDMIITPSVLA 1288
Cdd:cd05930    121 LLLWMQEAYPLTPGD----RVLQFTSFSFDVSVWEIFGALLAGATLVVLPEEVrKDPEALADLLAEEGITVLHLTPSLLR 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1289 TV----DPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWAT----RSRMTAGKPVTIGKPVDGFTV 1358
Cdd:cd05930    197 LLlqelELAALPSLRLVLVGGEALPPDLVRRWRELlpGARLVNLYGPTEATVDATyyrvPPDDEEDGRVPIGRPIPNTRV 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1359 RVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGePGARMYATGDLVRVAKGGNLEFAGRADHQVKIN 1438
Cdd:cd05930    277 YVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFG-PGERMYRTGDLVRWLPDGNLEFLGRIDDQVKIR 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1439 GQRVELGEIEAVLDAQPGVAQSVVVGVESTRGgrkHTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIP 1518
Cdd:cd05930    356 GYRIELGEIEAALLAHPGVREAAVVAREDGDG---EKRLVAYVVPDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALP 432

                          490
                   ....*....|..
gi 1827387616 1519 LTPAGKLDRAAL 1530
Cdd:cd05930    433 LTPNGKVDRKAL 444

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

2579-3060

1.49e-161

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 507.18 E-value: 1.49e-161

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd17652      1 PDAPAVVFG-DETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYM 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLSvlasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevTAANLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd17652     80 LADARPALLLT-------------------------------------------TPDNLAYVIYTSGSTGRPKGVVVTHR 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEA-VGGEVLERFIAEHGATHTFLTPSVLS 2817
Cdd:cd17652    117 GLANLAAAQIAAFDVGPGSRVLQFASPSFDASVWELLMALLAGATLVLAPAEElLPGEPLADLLREHRITHVTLPPAALA 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2818 TMDPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPV 2897
Cdd:cd17652    197 ALPPDDLPDLRTLVVAGEACPAELVDRWAPGRRMINAYGPTETTVCATMAGPLPGGGVPPIGRPVPGTRVYVLDARLRPV 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2898 PVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIE 2977
Cdd:cd17652    277 PPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFGAPGSRMYRTGDLARWRADGQ-----LEFLGRADDQVKIRGFRIE 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2978 LGEIEAVLAEHDAVESAVVL----GVGGSvatALAAYIVPVDG-AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVG 3052
Cdd:cd17652    352 LGEVEAALTEHPGVAEAVVVvrddRPGDK---RLVAYVVPAPGaAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNG 428


                   ....*...
gi 1827387616 3053 KLDKRALP 3060
Cdd:cd17652    429 KLDRRALP 436

entF

enterobactin non-ribosomal peptide synthetase EntF;

1-547

5.26e-159

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 531.16 E-value: 5.26e-159

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTs 80
Cdd:PRK10252   484 FSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITT- 562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeAEARSRFDDIVDVHVLDISSPgDADLDEEEfAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:PRK10252   563 ---ADQLPRFADVPDLTSLCYNAP-LAPQGAAP-LQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLT 637

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFnevlgagVGELT-- 238
Cdd:PRK10252   638 ADDVVLQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSMLAAF-------VASLTpe 710

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 -------SLRLIQTGGEALtPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD------RVIPIGTPTRRVSARV 305
Cdd:PRK10252   711 garqscaSLRQVFCSGEAL-PADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEElaavrgSSVPIGYPVWNTGLRI 789

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  306 LDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQ 385
Cdd:PRK10252   790 LDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFA-PGERMYRTGDVARWLDDGAVEYLGRSDDQLKIRGQ 868

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  386 RLELGEVEAALAAAPGVLHAAA-------AVVDGPGGQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSAWVRLDAM 455
Cdd:PRK10252   869 RIELGEIDRAMQALPDVEQAVThacvinqAAATGGDARQLVGYLVSQSglpLDTSALQAQLRERLPPHMVPVVLLQLDQL 948

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  456 PLSRSGKVDRRLLPEPEIAP-TLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVS 534
Cdd:PRK10252   949 PLSANGKLDRKALPLPELKAqVPGRAPKTGTETIIAAAFSSLLGCDVVDADADFFALGGHSLLAMKLAAQLSRQFARQVT 1028

                          570
                   ....*....|...
gi 1827387616  535 VRDVFESPSVRGL 547
Cdd:PRK10252  1029 PGQVMVASTVAKL 1041

PRK12316

peptide synthase; Provisional

1-995

5.54e-154

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 541.09 E-value: 5.54e-154

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtS 80
Cdd:PRK12316   537 LDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDPEYPAERLAYMLEDSGVQLLL--S 614

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVDVHVLDISSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:PRK12316   615 QSHLGRKLPLAAGVQVLDLDRPAAWLEGYSEENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGLG 694

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFneVLGAGVGELTSL 240
Cdd:PRK12316   695 VGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQAF--LQDEDVASCTSL 772

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVT-IHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPG 319
Cdd:PRK12316   773 RRIVCSGEALPADAQEQVFAKLPQAGLYNLYGPTEAAIDVThWTCVEEGGDSVPIGRPIANLACYILDANLEPVPVGVLG 852

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  320 ELYLGGVQLARGYAGRPDLTAERFVADPFGEpGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA 399
Cdd:PRK12316   853 ELYLAGRGLARGYHGRPGLTAERFVPSPFVA-GERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEH 931

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  400 PGVLHAAAAVVDgpgGQQLVGYLAPADVDVDTVAATTAEL---LPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPE--IA 474
Cdd:PRK12316   932 PWVREAAVLAVD---GKQLVGYVVLESEGGDWREALKAHLaasLPEYMVPAQWLALERLPLTPNGKLDRKALPAPEasVA 1008

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  475 PTLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARvSKELGVDVSVRDVFESPSVRGLVHaVSGR 554
Cdd:PRK12316  1009 QQGYVAPRNALERTLAAIWQDVLGVERVGLDDNFFELGGDSIVSIQVVSR-ARQAGIQLSPRDLFQHQTIRSLAL-VAKA 1086

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  555 GSALPSVKriEPRPERLPLSRAQRrmWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAA 634
Cdd:PRK12316  1087 GQATAADQ--GPASGEVALAPVQR--WFFEQAIPQRQHWNQSLLLQARQPLDPDRLGRALERLVAHHDALRLRFREEDGG 1162

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  635 PVQDVLPvAVAREQLDWREADSVESLVRSTTEG---FDVStQMPLRGRFHRDGA--GLHVALTMHHIAMDGQSIPVLARD 709
Cdd:PRK12316  1163 WQQAYAA-PQAGEVLWQRQAASEEELLALCEEAqrsLDLE-QGPLLRALLVDMAdgSQRLLLVIHHLVVDGVSWRILLED 1240

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  710 LMSAYA---ARAEGRTGGlpvldvqyadYALWQQSVLGDAddetSVLGEQLSHWRRVLAGLPavTDLPMDRPRPAVLGTA 786
Cdd:PRK12316  1241 LQRAYAdldADLPARTSS----------YQAWARRLHEHA----GARAEELDYWQAQLEDAP--HELPCENPDGALENRH 1304

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  787 GATVTVEFDDDLADRVDVLARSNTMTgfMVTE---AAFAATVARLASTTDVVIGTPVAGRNDPA----LEELIGMFvnTL 859
Cdd:PRK12316  1305 ERKLELRLDAERTRQLLQEAPAAYRT--QVNDlllTALARVTCRWSGQASVLVQLEGHGREDLFedidLSRTVGWF--TS 1380

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  860 LLRTQVDPGHSVGDLLGNVRTTvLDAFANDQVQFDeLIEALAPE---RSSSHQPLAQIAFTYT---EPTVNDVAGLEASG 933
Cdd:PRK12316  1381 LFPVRLTPAADLGESIKAIKEQ-LRAVPDKGIGYG-LLRYLAGEeaaARLAALPQPRITFNYLgqfDRQFDEAALFVPAT 1458

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  934 IQAAPVDTGvvNAKFDLTVAVRARSGGTPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVD 995
Cdd:PRK12316  1459 ESAGAAQDP--CAPLANWLSIEGQVYGGELSLHWSFSREMFAEATVQRLADDYARELQALIE 1518

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

1050-1531

6.21e-153

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 482.52 E-value: 6.21e-153

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17652      1 PDAPAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAStrarlgesscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd17652     81 ADARPALLLTTPD----------------------------------------NLAYVIYTSGSTGRPKGVVVTHRGLAN 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQAD-FAGDALATVLERDEVTDMIITPSVLA 1288
Cdd:cd17652    121 LAAAQIAAFDVGPGS----RVLQFASPSFDASVWELLMALLAGATLVLAPAEElLPGEPLADLLREHRITHVTLPPAALA 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1289 TVDPERAQYVRNLATGGEACPPELVERWSeRGRRIFNCYGPTEATVWATRSRM-TAGKPVTIGKPVDGFTVRVLDGRLHE 1367
Cdd:cd17652    197 ALPPDDLPDLRTLVVAGEACPAELVDRWA-PGRRMINAYGPTETTVCATMAGPlPGGGVPPIGRPVPGTRVYVLDARLRP 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1368 VPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEI 1447
Cdd:cd17652    276 VPPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFGAPGSRMYRTGDLARWRADGQLEFLGRADDQVKIRGFRIELGEV 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1448 EAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd17652    356 EAALTEHPGVAEAVVVVRDDRPGDKR---LVAYVVPAPGAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDR 432


                   ....
gi 1827387616 1528 AALP 1531
Cdd:cd17652    433 RALP 436

PRK05691

peptide synthase; Validated

2141-3145

7.31e-150

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 527.04 E-value: 7.31e-150

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2141 LSLTGDVDPGRLRSALSELLARQRVLRSGFVRlPSGAAVTVVPAEVTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFD 2220
Cdd:PRK05691   704 LHLRGELDEAALRASFQRLVERHESLRTRFYE-RDGVALQRIDAQGEFALQRIDLSDLPEAEREARAAQIREEEARQPFD 782

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2221 MAKPPLIRVVLVEHGDGA-ELVVTNHHLLIDGWSSPLVLADLLSLYAT---GQTFTGSLPGTSGRDFADHARA-VATADV 2295
Cdd:PRK05691   783 LEKGPLLRVTLVRLDDEEhQLLVTLHHIVADGWSLNILLDEFSRLYAAacqGQTAELAPLPLGYADYGAWQRQwLAQGEA 862

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2296 EAGIAAWREVLAPvTEPTLVAPGHEPSA---DAPPRDHQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTR 2372
Cdd:PRK05691   863 ARQLAYWKAQLGD-EQPVLELATDHPRSarqAHSAARYSLRVDASLSEALRGLAQAHQATLFMVLLAAFQALLHRYSGQG 941

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2373 TVTFAETVSGRsPDIEgMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVA---QTGLPALFD 2449
Cdd:PRK05691   942 DIRIGVPNANR-PRLE-TQGLVGFFINTQVLRAQLDGRLPFTALLAQVRQATLGAQAHQDLPFEQLVEalpQAREQGLFQ 1019

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2450 TLAVYESFpvnvdsvagiDASSAGGLKLVGAKT----SDATHYPLNL-SASRRGAELALKLKYLPTAFAPEQVAVFADVL 2524
Cdd:PRK05691  1020 VMFNHQQR----------DLSALRRLPGLLAEElpwhSREAKFDLQLhSEEDRNGRLTLSFDYAAELFDAATIERLAEHF 1089

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2525 TGLLGAIADHPEATCAEIPLLPAEAAVELTPVTGGPATDP-VTLAELFRAAARRAPDHVAVVdGAGARLTYRELDEASDR 2603
Cdd:PRK05691  1090 LALLEQVCEDPQRALGDVQLLDAAERAQLAQWGQAPCAPAqAWLPELLNEQARQTPERIALV-WDGGSLDYAELHAQANR 1168

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2604 LARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLSVLAS-GDLPGQEfe 2682
Cdd:PRK05691  1169 LAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSGVELLLTQSHLlERLPQAE-- 1246

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2683 wmrlDDDSVAAEIAAVPAGPITdAERLgEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR--QESDRLNAGDnpVVL 2760
Cdd:PRK05691  1247 ----GVSAIALDSLHLDSWPSQ-APGL-HLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQwmQATYALDDSD--VLM 1318

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2761 GFASPSFDASVLEYLLATVNEGTLAYR-PSEAVGGEVLERFIAEHGATHTFLTPSVLSTM----DPTAVPSLRVIAAGGE 2835
Cdd:PRK05691  1319 QKAPISFDVSVWECFWPLITGCRLVLAgPGEHRDPQRIAELVQQYGVTTLHFVPPLLQLFidepLAAACTSLRRLFSGGE 1398

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2836 AVPQPIVDR---WAPATELHNLYGPTETTIGIT-ISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGA 2911
Cdd:PRK05691  1399 ALPAELRNRvlqRLPQVQLHNRYGPTETAINVThWQCQAEDGERSPIGRPLGNVLCRVLDAELNLLPPGVAGELCIGGAG 1478

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2912 LSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAV 2991
Cdd:PRK05691  1479 LARGYLGRPALTAERFVPDPLGEDGARLYRTGDRARWNADG-----ALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGV 1553

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2992 ESAVVLGVGGSVATALAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGEYV 3070
Cdd:PRK05691  1554 AQAAVLVREGAAGAQLVGYYTGEAGQeAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALPEPVWQQREHV 1633

                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 3071 APATGTERTIADVAAGVLNI-DAGLvsaTSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAETVG 3145
Cdd:PRK05691  1634 EPRTELQQQIAAIWREVLGLpRVGL---RDDFFALGGHSLLATQIVSRTRQACDVELPLRALFEASELGAFAEQVA 1706

entF

enterobactin non-ribosomal peptide synthetase EntF;

565-1606

2.70e-149

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 502.65 E-value: 2.70e-149

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  565 EPRPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRT--------VYPSVGAAPV 636
Cdd:PRK10252     2 EPMSQHLPLVAAQPGIWMAEKLSPLPSAWSVAHYVELTGELDAPLLARAVVAGLAEADTLRMrftedngeVWQWVDPALT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  637 QDVLPVAVAREQLD-------WREADSVESLvrsttegfDVSTQMPL-RGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLA 707
Cdd:PRK10252    82 FPLPEIIDLRTQPDphaaaqaLMQADLQQDL--------RVDSGKPLvFHQLIQLGDNRWYwYQRYHHLLVDGFSFPAIT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  708 RDLMSAYAARAEGR---TGGLPVLDVQYADYALWQQSVLGDADDetsvlgeqlSHWRRVLAGLPAVTDLPmdrPRPAVLG 784
Cdd:PRK10252   154 RRIAAIYCAWLRGEptpASPFTPFADVVEEYQRYRASEAWQRDA---------AFWAEQRRQLPPPASLS---PAPLPGR 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  785 TAGAT---VTVEFDDDLADRVDVLARSNTMTGFMVteAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLL 861
Cdd:PRK10252   222 SASADilrLKLEFTDGAFRQLAAQASGVQRPDLAL--ALVALWLGRLCGRMDYAAGFIFMRRLGSAALTATGPVLNVLPL 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  862 RTQVDPGHSVGDLLGNVRTTVLDA-----FANDQVQFDElieALAPERSSSHQPLAQIAFTYTEPtvnDVAGLEAsgiQA 936
Cdd:PRK10252   300 RVHIAAQETLPELATRLAAQLKKMrrhqrYDAEQIVRDS---GRAAGDEPLFGPVLNIKVFDYQL---DFPGVQA---QT 370

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  937 APVDTGVVNakfDLTVAVRARSGGTpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAARAKSVS 1016
Cdd:PRK10252   371 HTLATGPVN---DLELALFPDEHGG-LSIEILANPQRYDEATLIAHAERLKALIAQFAADPALLCGDVDILLPGEYAQLA 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1017 APVSARTPgamvgrggeVEAGTLIDVLA-QRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMER 1095
Cdd:PRK10252   447 QVNATAVE---------IPETTLSALVAqQAAKTPDAPALADARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPR 517

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1096 SIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARL-----GESSCEWVDLADLEAEAESGDDI 1170
Cdd:PRK10252   518 SVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITTADQLPRFadvpdLTSLCYNAPLAPQGAAPLQLSQP 597

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1171 TDTerngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIvdfVNSLAKITTGTPEdEPDTRILHVASPSFDASMFEMAWAIP 1250
Cdd:PRK10252   598 HHT-----------AYIIFTSGSTGRPKGVMVGQTAI---VNRLLWMQNHYPL-TADDVVLQKTPCSFDVSVWEFFWPFI 662

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1251 AGHTLVIA-PQADFAGDALATVLERDEVTDMIITPSVL----ATVDPERA----QYVRNLATGGEACPPELVERWSER-G 1320
Cdd:PRK10252   663 AGAKLVMAePEAHRDPLAMQQFFAEYGVTTTHFVPSMLaafvASLTPEGArqscASLRQVFCSGEALPADLCREWQQLtG 742

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1321 RRIFNCYGPTEATV-------WATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQ 1393
Cdd:PRK10252   743 APLHNLYGPTEAAVdvswypaFGEELAAVRGSSVPIGYPVWNTGLRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDL 822

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1394 TAVSFVADPFGePGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRG--- 1470
Cdd:PRK10252   823 TASRFIADPFA-PGERMYRTGDVARWLDDGAVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEQAVTHACVINQAaat 901

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1471 GRKHTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPEPAEYVAPANPAED 1550
Cdd:PRK10252   902 GGDARQLVGYLVSQSGLPLDTSALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKALPLPELKAQVPGRAPKTGTET 981

                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 1551 NLARIVAGLLGEERVSVTESFFALGGDSIMSIQLSSAAKAA-GIHLSPREIFELKTI 1606
Cdd:PRK10252   982 IIAAAFSSLLGCDVVDADADFFALGGHSLLAMKLAAQLSRQfARQVTPGQVMVASTV 1038

PRK12316

peptide synthase; Provisional

2087-3144

1.00e-148

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 523.75 E-value: 1.00e-148

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2087 VEVTQDDLDLIAQQYPGADVWPMTPLQQGLFFQADLANTVAdhdaidVYVTQTVLSLTGDVDPGRLRSALSELLARQRVL 2166
Cdd:PRK12316  2583 LESGQTSRAPVLQKVTRVQPLPLSHAQQRQWFLWQLEPESA------AYHLPSALHLRGVLDQAALEQAFDALVLRHETL 2656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2167 RSGFVRLPSGAAVTVVPAEvtvpwSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGAE-LVVTNH 2245
Cdd:PRK12316  2657 RTRFVEVGEQTRQVILPNM-----SLRIVLEDCAGVADAAIRQRVAEEIQRPFDLARGPLLRVRLLALDGQEHvLVITQH 2731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2246 HLLIDGWSSPLVLADLLSLY---ATGQTFTGSLPGTSGRDFADHARA-VATADVEAGIAAWREVLAPvTEPTLVAPGHEP 2321
Cdd:PRK12316  2732 HIVSDGWSMQVMVDELVQAYagaRRGEQPTLPPLPLQYADYAAWQRAwMDSGEGARQLDYWRERLGG-EQPVLELPLDRP 2810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2322 SADAPPRD---HQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRspDIEGMESMVGMFI 2398
Cdd:PRK12316  2811 RPALQSHRgarLDVALDVALSRELLALARREGVTLFMLLLASFQVLLHRYSGQSDIRVGVPIANR--NRAETERLIGFFV 2888

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2399 NTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLV------AQTGLPALFDTLAVYESFPVNVDSVAGIDASSA 2472
Cdd:PRK12316  2889 NTQVLRAQVDAQLAFRDLLGQVKEQALGAQAHQDLPFEQLVealqpeRSLSHSPLFQVMYNHQSGERAAAQLPGLHIESF 2968

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2473 gglklvgAKTSDATHYPLNLSASRRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEA--- 2549
Cdd:PRK12316  2969 -------AWDGAATQFDLALDTWESAEGLGASLTYATDLFDARTVERLARHWQNLLRGMVENPQRSVDELAMLDAEErgq 3041

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2550 AVELTPVTGGPATDPVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQL 2629
Cdd:PRK12316  3042 LLEAWNATAAEYPLERGVHRLFEEQVERTPDAVALAFG-EQRLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEM 3120

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2630 LTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAgpitdaerl 2709
Cdd:PRK12316  3121 VVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQSHLRLPLAQGVQVLDLDRGDENYAEANPAI--------- 3191

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2710 gEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYR-P 2788
Cdd:PRK12316  3192 -RTMPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGDRVLQFTTFSFDVFVEELFWPLMSGARVVLAgP 3270

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2789 SEAVGGEVLERFIAEHGATHTFLTPSVLSTM----DPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETTIGI 2864
Cdd:PRK12316  3271 EDWRDPALLVELINSEGVDVLHAYPSMLQAFleeeDAHRCTSLKRIVCGGEALPADLQQQVFAGLPLYNLYGPTEATITV 3350

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2865 TISSAMRPG-DPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgTAGQRMYRTG 2943
Cdd:PRK12316  3351 THWQCVEEGkDAVPIGRPIANRACYILDGSLEPVPVGALGELYLGGEGLARGYHNRPGLTAERFVPDPF-VPGERLYRTG 3429

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2944 DVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSvatALAAYIVPVDGAVEVSE- 3022
Cdd:PRK12316  3430 DLARYRADG-----VIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVREAVVLAVDGR---QLVAYVVPEDEAGDLREa 3501

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3023 LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGE--YVAPATGTERTIADVAAGVLNIDAglVSATSS 3100
Cdd:PRK12316  3502 LKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKALPRPDAALLQqdYVAPVNELERRLAAIWADVLKLEQ--VGLTDN 3579

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 3101 FFELGGDSLSAARLAARlSDQLGVAVSVRDVFESGSIRALAETV 3144
Cdd:PRK12316  3580 FFELGGDSIISLQVVSR-ARQAGIRFTPKDLFQHQTIQGLARVA 3622

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

2569-3059

7.80e-147

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 467.14 E-value: 7.80e-147

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDP 2648
Cdd:cd17646      2 ALVAEQAARTPDAPAVVD-EGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2649 DYPAERVASMIEDSGAVLglsVLASGDLPGqefeWMRLDDDSVAAEIAAVPAGPITDAERlgEVTAANLAYVIYTSGSTG 2728
Cdd:cd17646     81 GYPADRLAYMLADAGPAV---VLTTADLAA----RLPAGGDVALLGDEALAAPPATPPLV--PPRPDNLAYVIYTSGSTG 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2729 RPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAY-RPSEAVGGEVLERFIAEHGAT 2807
Cdd:cd17646    152 RPKGVMVTHAGIVNRLLWMQDEYPLGPGDRVLQKTPLSFDVSVWELFWPLVAGARLVVaRPGGHRDPAYLAALIREHGVT 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2808 HTFLTPSVL----STMDPTAVPSLRVIAAGGEAVPQPIVDRWA--PATELHNLYGPTETTIGIT--ISSAMRPGDPVRLG 2879
Cdd:cd17646    232 TCHFVPSMLrvflAEPAAGSCASLRRVFCSGEALPPELAARFLalPGAELHNLYGPTEAAIDVThwPVRGPAETPSVPIG 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2880 GPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGtAGQRMYRTGDVVRWTPDTdtgglTL 2959
Cdd:cd17646    312 RPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFG-PGSRMYRTGDLARWRPDG-----AL 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2960 EYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG-GSVATALAAYIVPVDGAVEVS--ELKAFAGGRLPAYMV 3036
Cdd:cd17646    386 EFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAaPAGAARLVGYVVPAAGAAGPDtaALRAHLAERLPEYMV 465

                          490       500
                   ....*....|....*....|...
gi 1827387616 3037 PSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd17646    466 PAAFVVLDALPLTANGKLDRAAL 488

entF

enterobactin non-ribosomal peptide synthetase EntF;

2101-3141

1.12e-146

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 494.56 E-value: 1.12e-146

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2101 YPGADVWPMTPLQQGLFFqadlANTVADHDAIdvYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVT 2180
Cdd:PRK10252     2 EPMSQHLPLVAAQPGIWM----AEKLSPLPSA--WSVAHYVELTGELDAPLLARAVVAGLAEADTLRMRFTEDNGEVWQW 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2181 VVPAEVTVPWSVIDLRAEDAASLDSRVeeVLATERTNPFDMAK-PPLIRVVLVEHGDGAELVVTN-HHLLIDGWSSPLVL 2258
Cdd:PRK10252    76 VDPALTFPLPEIIDLRTQPDPHAAAQA--LMQADLQQDLRVDSgKPLVFHQLIQLGDNRWYWYQRyHHLLVDGFSFPAIT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2259 ADLLSLYAT----GQTFTGSLPGTSGRdFADHARAVATADVEAGIAAWREVLAPVTEPTLVAPGHEPSADAPPRDHQFS- 2333
Cdd:PRK10252   154 RRIAAIYCAwlrgEPTPASPFTPFADV-VEEYQRYRASEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKl 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2334 -IDVKVTERLEALARNNSTT-MATVVQFAWamfLSRLTGTRTVTFAETVSGR--SPDIegmeSMVGMFINTIPAVVDVNP 2409
Cdd:PRK10252   233 eFTDGAFRQLAAQASGVQRPdLALALVALW---LGRLCGRMDYAAGFIFMRRlgSAAL----TATGPVLNVLPLRVHIAA 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2410 DATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLPA----LFDTLAVYESFPVNVDsVAGIDAssagglklvgaKTSDA 2485
Cdd:PRK10252   306 QETLPELATRLAAQLKKMRRHQRYDAEQIVRDSGRAAgdepLFGPVLNIKVFDYQLD-FPGVQA-----------QTHTL 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2486 THYPLN-LSASRRGAE---LALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEAAVELTPVTggpA 2561
Cdd:PRK10252   374 ATGPVNdLELALFPDEhggLSIEILANPQRYDEATLIAHAERLKALIAQFAADPALLCGDVDILLPGEYAQLAQVN---A 450

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2562 TD----PVTLAELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVA 2637
Cdd:PRK10252   451 TAveipETTLSALVAQQAAKTPDAPALAD-ARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIV 529

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2638 KTGGAYVPIDPDYPAERVASMIEDSGAVLglsVLASGDLPGqefewmRLDD--DSVAAEIAAVPAGPitDAERLGEVTAA 2715
Cdd:PRK10252   530 EAGAAWLPLDTGYPDDRLKMMLEDARPSL---LITTADQLP------RFADvpDLTSLCYNAPLAPQ--GAAPLQLSQPH 598

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLAN--FARQESDRLNAGDnpVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEA-V 2792
Cdd:PRK10252   599 HTAYIIFTSGSTGRPKGVMVGQTAIVNrlLWMQNHYPLTADD--VVLQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAhR 676

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2793 GGEVLERFIAEHGATHTFLTPSVLSTM--------DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTI 2862
Cdd:PRK10252   677 DPLAMQQFFAEYGVTTTHFVPSMLAAFvasltpegARQSCASLRQVFCSGEALPADLCREWQQLTgaPLHNLYGPTEAAV 756

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2863 GITI------SSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGtAG 2936
Cdd:PRK10252   757 DVSWypafgeELAAVRGSSVPIGYPVWNTGLRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFA-PG 835

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2937 QRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-------GGSVATALAA 3009
Cdd:PRK10252   836 ERMYRTGDVARWLDDG-----AVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEQAVTHACvinqaaaTGGDARQLVG 910

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3010 YIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGEY-VAPATGTERTIADVAAGV 3087
Cdd:PRK10252   911 YLVSQSGLpLDTSALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKALPLPELKAQVPgRAPKTGTETIIAAAFSSL 990

                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 3088 LNIDAglVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALA 3141
Cdd:PRK10252   991 LGCDV--VDADADFFALGGHSLLAMKLAAQLSRQFARQVTPGQVMVASTVAKLA 1042

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

2569-3059

2.20e-143

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 457.05 E-value: 2.20e-143

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDP 2648
Cdd:cd12117      1 ELFEEQAARTPDAVAVVYG-DRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2649 DYPAERVASMIEDSGAVLglsVLASGDLPGqefewmRLDDDSVAAEIAAVPAGPITDAERLGeVTAANLAYVIYTSGSTG 2728
Cdd:cd12117     80 ELPAERLAFMLADAGAKV---LLTDRSLAG------RAGGLEVAVVIDEALDAGPAGNPAVP-VSPDDLAYVMYTSGSTG 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2729 RPKGVAVTHSGLANFARqESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAV-GGEVLERFIAEHGAT 2807
Cdd:cd12117    150 RPKGVAVTHRGVVRLVK-NTNYVTLGPDDRVLQTSPLAFDASTFEIWGALLNGARLVLAPKGTLlDPDALGALIAEEGVT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2808 HTFLTPSVLSTM---DPTAVPSLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIgITISSAMRPGDPVR---- 2877
Cdd:cd12117    229 VLWLTAALFNQLadeDPECFAGLRELLTGGEVVSPPHVRRVlaaCPGLRLVNGYGPTENTT-FTTSHVVTELDEVAgsip 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2878 LGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGtAGQRMYRTGDVVRWTPDtdtggL 2957
Cdd:cd12117    308 IGRPIANTRVYVLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPFG-PGERLYRTGDLARWLPD-----G 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2958 TLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAV-ESAVVLGVGGSVATALAAYIVPvDGAVEVSELKAFAGGRLPAYMV 3036
Cdd:cd12117    382 RLEFLGRIDDQVKIRGFRIELGEIEAALRAHPGVrEAVVVVREDAGGDKRLVAYVVA-EGALDAAELRAFLRERLPAYMV 460

                          490       500
                   ....*....|....*....|...
gi 1827387616 3037 PSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd12117    461 PAAFVVLDELPLTANGKVDRRAL 483

LCL_NRPS-like

cd19531

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar ...

570-996

7.30e-143

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity; LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.

Pssm-ID: 380454 [Multi-domain] Cd Length: 427 Bit Score: 452.96 E-value: 7.30e-143

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLP---VAVAR 646
Cdd:cd19531      1 PLPLSFAQQRLWFLDQLEPGSAAYNIPGALRLRGPLDVAALERALNELVARHEALRTTFVEVDGEPVQVILPplpLPLPV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  647 EQL-----DWREADsVESLVRS-TTEGFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARAE 719
Cdd:cd19531     81 VDLsglpeAEREAE-AQRLAREeARRPFDLARGPLLRATLLRLGEDEHVlLLTMHHIVSDGWSMGVLLRELAALYAAFLA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  720 GRTGGLPVLDVQYADYALWQQSVLgdaddETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLA 799
Cdd:cd19531    160 GRPSPLPPLPIQYADYAVWQREWL-----QGEVLERQLAYWREQLAGAPPVLELPTDRPRPAVQSFRGARVRFTLPAELT 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  800 DRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVR 879
Cdd:cd19531    235 AALRALARREGATLFMTLLAAFQVLLHRYSGQDDIVVGTPVAGRNRAELEGLIGFFVNTLVLRTDLSGDPTFRELLARVR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  880 TTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEPtvnDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRARSG 959
Cdd:cd19531    315 ETALEAYAHQDLPFEKLVEALQPERDLSRSPLFQVMFVLQNA---PAAALELPGLTVEPLEVDSGTAKFDLTLSLTETDG 391

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1827387616  960 GtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19531    392 G--LRGSLEYNTDLFDAATIERMAGHFQTLLEAIVAD 426

PRK12467

peptide synthase; Provisional

1-757

6.49e-142

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 500.84 E-value: 6.49e-142

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVts 80
Cdd:PRK12467  3121 LSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIEDSGVKLLLT-- 3198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgEAEARSRFDDIVDVHVLDISSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:PRK12467  3199 --QAHLLEQLPAPAGDTALTLDRLDLNGYSENNPSTRVMGENLAYVIYTSGSTGKPKGVGVRHGALANHLCWIAEAYELD 3276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAePGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEvlGAGVGELTSL 240
Cdd:PRK12467  3277 ANDRVLLFMSFSFDGAQERFLWTLICGGCLVVR-DNDLWDPEELWQAIHAHRISIACFPPAYLQQFAE--DAGGADCASL 3353

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDR----VIPIGTPTRRVSARVLDAALREVPIG 316
Cdd:PRK12467  3354 DIYVFGGEAVPPAAFEQVKRKLKPRGLTNGYGPTEAVVTVTLWKCGGDAVceapYAPIGRPVAGRSIYVLDGQLNPVPVG 3433

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  317 VPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAAL 396
Cdd:PRK12467  3434 VAGELYIGGVGLARGYHQRPSLTAERFVADPFSGSGGRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARL 3513

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  397 AAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVD---TVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEI 473
Cdd:PRK12467  3514 LQHPSVREAVVLARDGAGGKQLVAYVVPADPQGDwreTLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKALPDPDA 3593

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  474 APT-LYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVRGLVhAVS 552
Cdd:PRK12467  3594 KGSrEYVAPRSEVEQQLAAIWADVLGVEQVGVTDNFFELGGDSLLALQVLSRIRQSLGLKLSLRDLMSAPTIAELA-GYS 3672

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  553 GRGSALPSVKrieprperLPLSRAQRrmwflnqfdtasgaynipaaltlagdvdetllfdSLCDVVERHEVLRTVYpsvg 632
Cdd:PRK12467  3673 PLGDVPVNLL--------LDLNRLET----------------------------------GFPALFCRHEGLGTVF---- 3706

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  633 aapvqDVLPVAVAreqldwreadsveslvrsttegfdvstqmpLRGRFHRDGaglhvaLTMHHIAMDGQSIPvlardlms 712
Cdd:PRK12467  3707 -----DYEPLAVI------------------------------LEGDRHVLG------LTCRHLLDDGWQDT-------- 3737

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616  713 ayaaraegrtgGLPVLDVQYADYALWQQsvlgdADDETSVLGEQL 757
Cdd:PRK12467  3738 -----------SLQAMAVQYADYILWQQ-----AKGPYGLLGWSL 3766

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

2579-3059

4.24e-139

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 444.04 E-value: 4.24e-139

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd12116      1 PDATAVRDDDR-SLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLglsVLASGDLPGqefewmRLDDDSVAAEIAaVPAGPITDAERLGEVTAANLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd12116     80 LEDAEPAL---VLTDDALPD------RLPAGLPVLLLA-LAAAAAAPAAPRTPVSPDDLAYVIYTSGSTGRPKGVVVSHR 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAV-GGEVLERFIAEHGATHTFLTPSV-- 2815
Cdd:cd12116    150 NLVNFLHSMRERLGLGPGDRLLAVTTYAFDISLLELLLPLLAGARVVIAPRETQrDPEALARLIEAHSITVMQATPATwr 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2816 -LSTMDPTAVPSLRVIAaGGEAVPQPIVDRW-APATELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDER 2893
Cdd:cd12116    230 mLLDAGWQGRAGLTALC-GGEALPPDLAARLlSRVGSLWNLYGPTETTIWSTAARVTAAAGPIPIGRPLANTQVYVLDAA 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2894 LRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRG 2973
Cdd:cd12116    309 LRPVPPGVPGELYIGGDGVAQGYLGRPALTAERFVPDPFAGPGSRLYRTGDLVRRRADG-----RLEYLGRADGQVKIRG 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2974 LRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDG-AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVG 3052
Cdd:cd12116    384 HRIELGEIEAALAAHPGVAQAAVVVREDGGDRRLVAYVVLKAGaAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANG 463


                   ....*..
gi 1827387616 3053 KLDKRAL 3059
Cdd:cd12116    464 KLDRKAL 470

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

2569-3062

2.16e-138

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 442.92 E-value: 2.16e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDP 2648
Cdd:cd17655      1 ELFEEQAEKTPDHTAVVFE-DQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2649 DYPAERVASMIEDSGAVLglsVLASGDLPGQEF---EWMRLDDDSVAAEiaavpagPITDAERlgEVTAANLAYVIYTSG 2725
Cdd:cd17655     80 DYPEERIQYILEDSGADI---LLTQSHLQPPIAfigLIDLLDEDTIYHE-------ESENLEP--VSKSDDLAYVIYTSG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2726 STGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTL-AYRPSEAVGGEVLERFIAEH 2804
Cdd:cd17655    148 STGKPKGVMIEHRGVVNLVEWANKVIYQGEHLRVALFASISFDASVTEIFASLLSGNTLyIVRKETVLDGQALTQYIRQN 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2805 GATHTFLTPSVLSTMDP---TAVPSLRVIAAGGEAVPQPIVDRW----APATELHNLYGPTETTIGITI---SSAMRPGD 2874
Cdd:cd17655    228 RITIIDLTPAHLKLLDAaddSEGLSLKHLIVGGEALSTELAKKIielfGTNPTITNAYGPTETTVDASIyqyEPETDQQV 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2875 PVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgTAGQRMYRTGDVVRWTPDTdt 2954
Cdd:cd17655    308 SVPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPF-VPGERMYRTGDLARWLPDG-- 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2955 gglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV---GGSVatALAAYIVPvDGAVEVSELKAFAGGRL 3031
Cdd:cd17655    385 ---NIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKEAVVIARkdeQGQN--YLCAYIVS-EKELPVAQLREFLAREL 458

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1827387616 3032 PAYMVPSSFTVIDELPLTPVGKLDKRALPEP 3062
Cdd:cd17655    459 PDYMIPSYFIKLDEIPLTPNGKVDRKALPEP 489

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

1-468

2.33e-138

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 442.41 E-value: 2.33e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtS 80
Cdd:cd12117     23 LTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPELPAERLAFMLADAGAKVLL--T 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRfDDIVDVHVLDISSPGDAdldeEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIAnRLAADIEQYDLT 160
Cdd:cd12117    101 DRSLAGRAG-GLEVAVVIDEALDAGPA----GNPAVPVSPDDLAYVMYTSGSTGRPKGVAVTHRGVV-RLVKNTNYVTLG 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMlaaFNEVLGAGVGELTSL 240
Cdd:cd12117    175 PDDRVLQTSPLAFDASTFEIWGALLNGARLVLAPKGTLLDPDALGALIAEEGVTVLWLTAAL---FNQLADEDPECFAGL 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRV---IPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:cd12117    252 RELLTGGEVVSPPHVRRVLAACPGLRLVNGYGPTENTTFTTSHVVTELDEVagsIPIGRPIANTRVYVLDEDGRPVPPGV 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA 397
Cdd:cd12117    332 PGELYVGGDGLALGYLNRPALTAERFVADPFG-PGERLYRTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALR 410

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  398 AAPGVLHAAAAVV-DGPGGQQLVGYLAPA-DVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd12117    411 AHPGVREAVVVVReDAGGDKRLVAYVVAEgALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

4-407

5.77e-138

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 438.24 E-value: 5.77e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLAREL-TALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDG 82
Cdd:TIGR01733    3 RELDERANRLARHLrAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSAL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   83 EAEARSRFDDIVDVHVLDiSSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTAR 162
Cdd:TIGR01733   83 ASRLAGLVLPVILLDPLE-LAALDDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDPD 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  163 DVFLYKAPITFDVSVREIFLPIAIGATLVIAEPG-RHGDPVHLADLIRRHGVTVIHFVPAMLAAFnevLGAGVGELTSLR 241
Cdd:TIGR01733  162 DRVLQFASLSFDASVEEIFGALLAGATLVVPPEDeERDDAALLAALIAEHPVTVLNLTPSLLALL---AAALPPALASLR 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  242 LIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDD----RVIPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:TIGR01733  239 LVILGGEALTPALVDRWRARGPGARLINLYGPTETTVWSTATLVDPDDapreSPVPIGRPLANTRLYVLDDDLRPVPVGV 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPF-GEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAAL 396
Cdd:TIGR01733  319 VGELYIGGPGVARGYLNRPELTAERFVPDPFaGGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAAL 398

                          410
                   ....*....|.
gi 1827387616  397 AAAPGVLHAAA 407
Cdd:TIGR01733  399 LRHPGVREAVV 409

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

1050-1530

1.13e-137

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 440.48 E-value: 1.13e-137

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd12117     11 PDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPELPAERLAFML 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGDditdterNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd12117     91 ADAGAKVLLTDRSLAGRAGGLEVAVVIDEALDAGPAGNP-------AVPVSPDDLAYVMYTSGSTGRPKGVAVTHRGVVR 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGtpedePDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFA-GDALATVLERDEVTDMIITPSV-- 1286
Cdd:cd12117    164 LVKNTNYVTLG-----PDDRVLQTSPLAFDASTFEIWGALLNGARLVLAPKGTLLdPDALGALIAEEGVTVLWLTAALfn 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1287 -LATVDPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRMTAGKPVT----IGKPVDGFTVR 1359
Cdd:cd12117    239 qLADEDPECFAGLRELLTGGEVVSPPHVRRVLAAcpGLRLVNGYGPTENTTFTTSHVVTELDEVAgsipIGRPIANTRVY 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1360 VLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGePGARMYATGDLVRVAKGGNLEFAGRADHQVKING 1439
Cdd:cd12117    319 VLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPFG-PGERLYRTGDLARWLPDGRLEFLGRIDDQVKIRG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1440 QRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPgaTIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPL 1519
Cdd:cd12117    398 FRIELGEIEAALRAHPGVREAVVVVREDAGGDK---RLVAYVVAEG--ALDAAELRAFLRERLPAYMVPAAFVVLDELPL 472

                          490
                   ....*....|.
gi 1827387616 1520 TPAGKLDRAAL 1530
Cdd:cd12117    473 TANGKVDRRAL 483

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

1050-1530

5.88e-137

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 437.88 E-value: 5.88e-137

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd12116      1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDASTRARLgeSSCEWVDLADLEAEAESGDditdtERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd12116     81 EDAEPALVLTDDALPDRL--PAGLPVLLLALAAAAAAPA-----APRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAP-QADFAGDALATVLERDEVTDMIITPSV-- 1286
Cdd:cd12116    154 FLHSMRERLGLGPGD----RLLAVTTYAFDISLLELLLPLLAGARVVIAPrETQRDPEALARLIEAHSITVMQATPATwr 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1287 -LATVDPERAQYVRNLAtGGEACPPELVERWSERGRRIFNCYGPTEATVWATRSRMTAGK-PVTIGKPVDGFTVRVLDGR 1364
Cdd:cd12116    230 mLLDAGWQGRAGLTALC-GGEALPPDLAARLLSRVGSLWNLYGPTETTIWSTAARVTAAAgPIPIGRPLANTQVYVLDAA 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1365 LHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVEL 1444
Cdd:cd12116    309 LRPVPPGVPGELYIGGDGVAQGYLGRPALTAERFVPDPFAGPGSRLYRTGDLVRRRADGRLEYLGRADGQVKIRGHRIEL 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1445 GEIEAVLDAQPGVAQSVVVGvestRGGRKHTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGK 1524
Cdd:cd12116    389 GEIEAALAAHPGVAQAAVVV----REDGGDRRLVAYVVLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGK 464


                   ....*.
gi 1827387616 1525 LDRAAL 1530
Cdd:cd12116    465 LDRKAL 470

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

2571-3060

1.14e-136

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 437.93 E-value: 1.14e-136

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2571 FRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDY 2650
Cdd:cd17651      1 FERQAARTPDAPALVAE-GRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2651 PAERVASMIEDSGAVLGLsvLASGDLPGQEfewmrlDDDSVAAEIAAVPAGPITDAERLGEVTAANLAYVIYTSGSTGRP 2730
Cdd:cd17651     80 PAERLAFMLADAGPVLVL--THPALAGELA------VELVAVTLLDQPGAAAGADAEPDPALDADDLAYVIYTSGSTGRP 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2731 KGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEA-VGGEVLERFIAEHGATHT 2809
Cdd:cd17651    152 KGVVMPHRSLANLVAWQARASSLGPGARTLQFAGLGFDVSVQEIFSTLCAGATLVLPPEEVrTDPPALAAWLDEQRISRV 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2810 FLTPSVL------STMDPTAVPSLRVIAAGGEAVP-QPIVDRW---APATELHNLYGPTETTIGITISSAMRPG---DPV 2876
Cdd:cd17651    232 FLPTVALralaehGRPLGVRLAALRYLLTGGEQLVlTEDLREFcagLPGLRLHNHYGPTETHVVTALSLPGDPAawpAPP 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2877 RLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTaGQRMYRTGDVVRWTPDTdtgg 2956
Cdd:cd17651    312 PIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFVP-GARMYRTGDLARWLPDG---- 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2957 lTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-GGSVATALAAYIVPVDGA-VEVSELKAFAGGRLPAY 3034
Cdd:cd17651    387 -ELEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAReDRPGEKRLVAYVVGDPEApVDAAELRAALATHLPEY 465

                          490       500
                   ....*....|....*....|....*.
gi 1827387616 3035 MVPSSFTVIDELPLTPVGKLDKRALP 3060
Cdd:cd17651    466 MVPSAFVLLDALPLTPNGKLDRRALP 491

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

1044-1530

4.26e-136

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 436.32 E-value: 4.26e-136

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1044 AQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:cd17646      6 EQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPGYPAD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGITDASTRARLGESSCewVDLADLEAEAESGDDITDTErngsVRLTNLAYLIYTSGSTGRPKAVGVS 1203
Cdd:cd17646     86 RLAYMLADAGPAVVLTTADLAARLPAGGD--VALLGDEALAAPPATPPLVP----PRPDNLAYVIYTSGSTGRPKGVMVT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1204 HTGIvdfVNSLAKITTGTPEDePDTRILHVASPSFDASMFEMAWAIPAGHTLVIA-PQADFAGDALATVLERDEVTDMII 1282
Cdd:cd17646    160 HAGI---VNRLLWMQDEYPLG-PGDRVLQKTPLSFDVSVWELFWPLVAGARLVVArPGGHRDPAYLAALIREHGVTTCHF 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1283 TPSVL----ATVDPERAQYVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGK---PVTIGKPVD 1354
Cdd:cd17646    236 VPSMLrvflAEPAAGSCASLRRVFCSGEALPPELAARFLALpGAELHNLYGPTEAAIDVTHWPVRGPAetpSVPIGRPVP 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1355 GFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGePGARMYATGDLVRVAKGGNLEFAGRADHQ 1434
Cdd:cd17646    316 NTRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFG-PGSRMYRTGDLARWRPDGALEFLGRSDDQ 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1435 VKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGAT-IDSAAVLDEAAQHLAAHMVPSQAIV 1513
Cdd:cd17646    395 VKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAPAGAAR---LVGYVVPAAGAAgPDTAALRAHLAERLPEYMVPAAFVV 471

                          490
                   ....*....|....*..
gi 1827387616 1514 IDEIPLTPAGKLDRAAL 1530
Cdd:cd17646    472 LDALPLTANGKLDRAAL 488

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

1-468

6.92e-136

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 434.80 E-value: 6.92e-136

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd12116     13 LSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYILEDAEPALVLTDD 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDdivdvhVLDISSPGDAdLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd12116     93 ALPDRLPAGLP------VLLLALAAAA-AAPAAPRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLGLG 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPA---MLaafnevLGAGVGEL 237
Cdd:cd12116    166 PGDRLLAVTTYAFDISLLELLLPLLAGARVVIAPRETQRDPEALARLIEAHSITVMQATPAtwrML------LDAGWQGR 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  238 TSLRLIqTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:cd12116    240 AGLTAL-CGGEALPPDLAARLLSR--VGSLWNLYGPTETTIWSTAARVTAAAGPIPIGRPLANTQVYVLDAALRPVPPGV 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA 397
Cdd:cd12116    317 PGELYIGGDGVAQGYLGRPALTAERFVPDPFAGPGSRLYRTGDLVRRRADGRLEYLGRADGQVKIRGHRIELGEIEAALA 396

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  398 AAPGVLHAAAAVVDGPGGQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd12116    397 AHPGVAQAAVVVREDGGDRRLVAYVVLKAgaaPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKLDRKAL 470

PRK12316

peptide synthase; Provisional

1-557

3.81e-134

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 475.99 E-value: 3.81e-134

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK12316  4577 LTYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSGAALLLTQS 4656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaEARSRFDDIVDVHVLDISSPGD-ADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDL 159
Cdd:PRK12316  4657 ----HLLQRLPIPDGLASLALDRDEDwEGFPAHDPAVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYEL 4732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHgDPVHLADLIRRHGVTVIHFVPAMLAAFNEvlGAGV-GELT 238
Cdd:PRK12316  4733 TPDDRVLQFMSFSFDGSHEGLYHPLINGASVVIRDDSLW-DPERLYAEIHEHRVTVLVFPPVYLQQLAE--HAERdGEPP 4809

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 SLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDR----VIPIGTPTRRVSARVLDAALREVP 314
Cdd:PRK12316  4810 SLRVYCFGGEAVAQASYDLAWRALKPVYLFNGYGPTETTVTVLLWKARDGDAcgaaYMPIGTPLGNRSGYVLDGQLNPLP 4889

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  315 IGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA 394
Cdd:PRK12316  4890 VGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGGRLYRTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIEA 4969

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  395 ALAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVDTVAATTAEL-----------LPEYMRPSAWVRLDAMPLSRSGKV 463
Cdd:PRK12316  4970 RLREHPAVREAVVIAQEGAVGKQLVGYVVPQDPALADADEAQAELrdelkaalrerLPEYMVPAHLVFLARMPLTPNGKL 5049

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  464 DRRLLPEPE--IAPTLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFES 541
Cdd:PRK12316  5050 DRKALPQPDasLLQQAYVAPRSELEQQVAAIWAEVLQLERVGLDDNFFELGGHSLLAIQVTSRIQLELGLELPLRELFQT 5129

                          570
                   ....*....|....*.
gi 1827387616  542 PSVRGLVHAVSGRGSA 557
Cdd:PRK12316  5130 PTLAAFVELAAAAGSG 5145

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

1-469

6.20e-134

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 428.33 E-value: 6.20e-134

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTs 80
Cdd:cd17649     13 LSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYMLEDSGAGLLLTH- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagptRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd17649     92 --------------------------------------HPRQLAYVIYTSGSTGTPKGVAVSHGPLAAHCQATAERYGLT 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGA-GVGELTS 239
Cdd:cd17649    134 PGDRELQFASFNFDGAHEQLLPPLICGACVVLRPDELWASADELAEMVRELGVTVLDLPPAYLQQLAEEADRtGDGRPPS 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARDLMVrlPGTRLQNQYGPAEASIVVTIHRVTQDDR----VIPIGTPTRRVSARVLDAALREVPI 315
Cdd:cd17649    214 LRLYIFGGEALSPELLRRWLK--APVRLFNAYGPTEATVTPLVWKCEAGAAragaSMPIGRPLGGRSAYILDADLNPVPV 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  316 GVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:cd17649    292 GVTGELYIGGEGLARGYLGRPELTAERFVPDPFGAPGSRLYRTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAA 371

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  396 LAAAPGVLHAAAAVVDGPGGQQLVGYLAPADV-----DVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:cd17649    372 LLEHPGVREAAVVALDGAGGKQLVAYVVLRAAaaqpeLRAQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

2593-2996

8.58e-134

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 426.30 E-value: 8.58e-134

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2593 TYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLSVL 2671
Cdd:TIGR01733    1 TYRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 ASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPITDAERLGEvtaaNLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRL 2751
Cdd:TIGR01733   81 ALASRLAGLVLPVILLDPLELAALDDAPAPPPPDAPSGPD----DLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRY 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVG--GEVLERFIAEHGATHTFLTPSVLSTMDPTAVP---S 2826
Cdd:TIGR01733  157 GLDPDDRVLQFASLSFDASVEEIFGALLAGATLVVPPEDEERddAALLAALIAEHPVTVLNLTPSLLALLAAALPPalaS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2827 LRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTIGITISSAMRPGD----PVRLGGPIGGVDLMVLDERLRPVPV 2899
Cdd:TIGR01733  237 LRLVILGGEALTPALVDRWRargPGARLINLYGPTETTVWSTATLVDPDDApresPVPIGRPLANTRLYVLDDDLRPVPV 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2900 GMPGELYVAGGALSRGYLDRSGLTAERFTANPY-GTAGQRMYRTGDVVRWTPDtdtGglTLEYTGRSDDQVKLRGLRIEL 2978
Cdd:TIGR01733  317 GVVGELYIGGPGVARGYLNRPELTAERFVPDPFaGGDGARLYRTGDLVRYLPD---G--NLEFLGRIDDQVKIRGYRIEL 391

                          410
                   ....*....|....*...
gi 1827387616 2979 GEIEAVLAEHDAVESAVV 2996
Cdd:TIGR01733  392 GEIEAALLRHPGVREAVV 409

PRK05691

peptide synthase; Validated

2143-3148

3.96e-133

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 472.35 E-value: 3.96e-133

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2143 LTGDVDPGRLRSALSELLARQRVLRSGFvrlPS--GAAVTVVPAEVTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFD 2220
Cdd:PRK05691  1759 LSGVLDVDRFEAALQALILRHETLRTTF---PSvdGVPVQQVAEDSGLRMDWQDFSALPADARQQRLQQLADSEAHQPFD 1835

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2221 MAKPPLIRVVLVEHGDGAE-LVVTNHHLLIDGWSSPLVLADLLSLYatgQTFTgslpgtSGRDFADHARAVATAD----- 2294
Cdd:PRK05691  1836 LERGPLLRACLVKAAEREHyFVLTLHHIVTEGWAMDIFARELGALY---EAFL------DDRESPLEPLPVQYLDysvwq 1906

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2295 ---VEAG-----IAAWREVLApvTE-PTLVAPGHEPSAdaPPRDHQ-----FSIDVKVTERLEALARNNSTTMATVVQFA 2360
Cdd:PRK05691  1907 rqwLESGerqrqLDYWKAQLG--NEhPLLELPADRPRP--PVQSHRgelyrFDLSPELAARVRAFNAQRGLTLFMTMTAT 1982

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2361 WAMFLSRLTGTRTVTFAETVSGR-SPDIEGMesmVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLV 2439
Cdd:PRK05691  1983 LAALLYRYSGQRDLRIGAPVANRiRPESEGL---IGAFLNTQVLRCQLDGQMSVSELLEQVRQTVIEGQSHQDLPFDHLV 2059

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2440 AQTGLP--ALFDTLavyesFPV--NVDSVAGIDASSAGGLKL-VGAKTSDATHYPLNLSASRRGAELALKLKYLPTAFAP 2514
Cdd:PRK05691  2060 EALQPPrsAAYNPL-----FQVmcNVQRWEFQQSRQLAGMTVeYLVNDARATKFDLNLEVTDLDGRLGCCLTYSRDLFDE 2134

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2515 EQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEAAVELTPVTGGPATDPV---TLAELFRAAARRAPDHVAVVdGAGAR 2591
Cdd:PRK05691  2135 PRIARMAEHWQNLLEALLGDPQQRLAELPLLAAAEQQQLLDSLAGEAGEARldqTLHGLFAAQAARTPQAPALT-FAGQT 2213

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLS-- 2669
Cdd:PRK05691  2214 LSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGAYVPLDPEYPLERLHYMIEDSGIGLLLSdr 2293

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2670 --VLASGDLPGQEFEWMrLDDDSVAaeIAAVPAGPItDAERLGEvtaaNLAYVIYTSGSTGRPKGVAVTHSGLANFARQE 2747
Cdd:PRK05691  2294 alFEALGELPAGVARWC-LEDDAAA--LAAYSDAPL-PFLSLPQ----HQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAV 2365

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2748 SDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSV-------LSTMD 2820
Cdd:PRK05691  2366 IERFGMRADDCELHFYSINFDAASERLLVPLLCGARVVLRAQGQWGAEEICQLIREQQVSILGFTPSYgsqlaqwLAGQG 2445

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2821 PTAvpSLRVIAAGGEAVP----QPIVDRWAPAtELHNLYGPTETtigITISSAMRPGDPVRLGG---PIGGV----DLMV 2889
Cdd:PRK05691  2446 EQL--PVRMCITGGEALTgehlQRIRQAFAPQ-LFFNAYGPTET---VVMPLACLAPEQLEEGAasvPIGRVvgarVAYI 2519

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2890 LDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDtdtgGLtLEYTGRSDDQV 2969
Cdd:PRK05691  2520 LDADLALVPQGATGELYVGGAGLAQGYHDRPGLTAERFVADPFAADGGRLYRTGDLVRLRAD----GL-VEYVGRIDHQV 2594

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2970 KLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIV-PVDGAVEVSE------LKAFAGGRLPAYMVPSSFTV 3042
Cdd:PRK05691  2595 KIRGFRIELGEIESRLLEHPAVREAVVLALDTPSGKQLAGYLVsAVAGQDDEAQaalreaLKAHLKQQLPDYMVPAHLIL 2674

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3043 IDELPLTPVGKLDKRALPEPVLEAG--EYVAPATGTERTIADVAAGVLNIDAglVSATSSFFELGGDSLSAARLAARlSD 3120
Cdd:PRK05691  2675 LDSLPLTANGKLDRRALPAPDPELNrqAYQAPRSELEQQLAQIWREVLNVER--VGLGDNFFELGGDSILSIQVVSR-AR 2751

                         1050      1060
                   ....*....|....*....|....*...
gi 1827387616 3121 QLGVAVSVRDVFESGSIRALAETVGGSE 3148
Cdd:PRK05691  2752 QLGIHFSPRDLFQHQTVQTLAAVATHSE 2779

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

1045-1533

1.62e-132

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 425.97 E-value: 1.62e-132

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1045 QRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADR 1124
Cdd:cd17655      6 QAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPDYPEER 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1125 IAYMLEDSGATVGITDASTRARL-GESSCEWVDLADLEAEaesgddiTDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVS 1203
Cdd:cd17655     86 IQYILEDSGADILLTQSHLQPPIaFIGLIDLLDEDTIYHE-------ESENLEPVSKSDDLAYVIYTSGSTGKPKGVMIE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1204 HTGIVDFVNSLAKIttgTPEDEPDtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQAD-FAGDALATVLERDEVTDMII 1282
Cdd:cd17655    159 HRGVVNLVEWANKV---IYQGEHL-RVALFASISFDASVTEIFASLLSGNTLYIVRKETvLDGQALTQYIRQNRITIIDL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1283 TPSVLATVDPERAQY---VRNLATGGEACPPELVERWSER---GRRIFNCYGPTEATVWATRSRMTAGKP----VTIGKP 1352
Cdd:cd17655    235 TPAHLKLLDAADDSEglsLKHLIVGGEALSTELAKKIIELfgtNPTITNAYGPTETTVDASIYQYEPETDqqvsVPIGKP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1353 VDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRAD 1432
Cdd:cd17655    315 LGNTRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPF-VPGERMYRTGDLARWLPDGNIEFLGRID 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1433 HQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGgrkHTEVVAYLVAKPgaTIDSAAVLDEAAQHLAAHMVPSQAI 1512
Cdd:cd17655    394 HQVKIRGYRIELGEIEARLLQHPDIKEAVVIARKDEQG---QNYLCAYIVSEK--ELPVAQLREFLARELPDYMIPSYFI 468

                          490       500
                   ....*....|....*....|.
gi 1827387616 1513 VIDEIPLTPAGKLDRAALPEP 1533
Cdd:cd17655    469 KLDEIPLTPNGKVDRKALPEP 489

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

4-469

4.99e-132

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 424.83 E-value: 4.99e-132

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtsdGE 83
Cdd:cd17651     24 AELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYPAERLAFMLADAGPVLVL----TH 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDIVDVHVLDISSPGDADLDEEEFAgPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd17651    100 PALAGELAVELVAVTLLDQPGAAAGADAEPDP-ALDADDLAYVIYTSGSTGRPKGVVMPHRSLANLVAWQARASSLGPGA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLI 243
Cdd:cd17651    179 RTLQFAGLGFDVSVQEIFSTLCAGATLVLPPEEVRTDPPALAAWLDEQRISRVFLPTVALRALAEHGRPLGVRLAALRYL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  244 QTGGEALTP-PVARDLMVRLPGTRLQNQYGPAEASiVVTIHRVTQD----DRVIPIGTPTRRVSARVLDAALREVPIGVP 318
Cdd:cd17651    259 LTGGEQLVLtEDLREFCAGLPGLRLHNHYGPTETH-VVTALSLPGDpaawPAPPPIGRPIDNTRVYVLDAALRPVPPGVP 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GELYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAA 398
Cdd:cd17651    338 GELYIGGAGLARGYLNRPELTAERFVPDPFV-PGARMYRTGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALAR 416

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616  399 APGVLHAAAAVV-DGPGGQQLVGYLAPADVDVDTVAATTAEL---LPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:cd17651    417 HPGVREAVVLAReDRPGEKRLVAYVVGDPEAPVDAAELRAALathLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

1064-1462

6.72e-131

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 417.82 E-value: 6.72e-131

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAS 1142
Cdd:TIGR01733    2 YRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1143 TRARLGESSCEWVDLADLEaEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTP 1222
Cdd:TIGR01733   82 LASRLAGLVLPVILLDPLE-LAALDDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1223 EDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDA--LATVLERDEVTDMIITPSVLATVDPERAQY--- 1297
Cdd:TIGR01733  161 DD----RVLQFASLSFDASVEEIFGALLAGATLVVPPEDEERDDAalLAALIAEHPVTVLNLTPSLLALLAAALPPAlas 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1298 VRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRMTAG-----KPVTIGKPVDGFTVRVLDGRLHEVPQ 1370
Cdd:TIGR01733  237 LRLVILGGEALTPALVDRWRARgpGARLINLYGPTETTVWSTATLVDPDdapreSPVPIGRPLANTRLYVLDDDLRPVPV 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1371 GVVGELYLSTAGLARGYLGRPGQTAVSFVADPF-GEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEA 1449
Cdd:TIGR01733  317 GVVGELYIGGPGVARGYLNRPELTAERFVPDPFaGGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEA 396

                          410
                   ....*....|...
gi 1827387616 1450 VLDAQPGVAQSVV 1462
Cdd:TIGR01733  397 ALLRHPGVREAVV 409

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

2569-3059

4.06e-129

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 415.79 E-value: 4.06e-129

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVV--DGagaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:cd05918      3 DLIEERARSQPDAPAVCawDG---SLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMIEDSGAVLglsVLASgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevTAANLAYVIYTSGS 2726
Cdd:cd05918     80 DPSHPLQRLQEILQDTGAKV---VLTS---------------------------------------SPSDAAYVIFTSGS 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2727 TGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYrPSEAVGGEVLERFIAEHGA 2806
Cdd:cd05918    118 TGKPKGVVIEHRALSTSALAHGRALGLTSESRVLQFASYTFDVSILEIFTTLAAGGCLCI-PSEEDRLNDLAGFINRLRV 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2807 THTFLTPSVLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVd 2886
Cdd:cd05918    197 TWAFLTPSVARLLDPEDVPSLRTLVLGGEALTQSDVDTWADRVRLINAYGPAECTIAATVSPVVPSTDPRNIGRPLGAT- 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2887 LMVLDER--LRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANP------YGTAGQRMYRTGDVVRWTPDtdtGglT 2958
Cdd:cd05918    276 CWVVDPDnhDRLVPIGAVGELLIEGPILARGYLNDPEKTAAAFIEDPawlkqeGSGRGRRLYRTGDLVRYNPD---G--S 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2959 LEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV----GGSVATALAAYIVPVDGAVE--------------- 3019
Cdd:cd05918    351 LEYVGRKDTQVKIRGQRVELGEIEHHLRQSLPGAKEVVVEVvkpkDGSSSPQLVAFVVLDGSSSGsgdgdslflepsdef 430

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 1827387616 3020 ---VSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05918    431 ralVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRAL 473

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

1-469

1.14e-128

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 412.80 E-value: 1.14e-128

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvts 80
Cdd:cd17652     13 LTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYMLADARPALLL--- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd17652     90 -------------------------------------TTPDNLAYVIYTSGSTGRPKGVVVTHRGLANLAAAQIAAFDVG 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEvlgagvGELTSL 240
Cdd:cd17652    133 PGSRVLQFASPSFDASVWELLMALLAGATLVLAPAEELLPGEPLADLLREHRITHVTLPPAALAALPP------DDLPDL 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMvrlPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGE 320
Cdd:cd17652    207 RTLVVAGEACPAELVDRWA---PGRRMINAYGPTETTVCATMAGPLPGGGVPPIGRPVPGTRVYVLDARLRPVPPGVPGE 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  321 LYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAP 400
Cdd:cd17652    284 LYIAGAGLARGYLNRPGLTAERFVADPFGAPGSRMYRTGDLARWRADGQLEFLGRADDQVKIRGFRIELGEVEAALTEHP 363

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  401 GVLHAAAAVV-DGPGGQQLVGYLAPADVDVDTVAATTAEL---LPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:cd17652    364 GVAEAVVVVRdDRPGDKRLVAYVVPAPGAAPTAAELRAHLaerLPGYMVPAAFVVLDALPLTPNGKLDRRALP 436

A_NRPS_Cytc1-like

cd17643

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

2579-3059

1.57e-125

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 404.38 E-value: 1.57e-125

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd17643      1 PEAVAVVDE-DRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLsvlasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgeVTAANLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd17643     80 LADSGPSLLL-------------------------------------------TDPDDLAYVIYTSGSTGRPKGVVVSHA 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSE-AVGGEVLERFIAEHGATHTFLTPSVLS 2817
Cdd:cd17643    117 NVLALFAATQRWFGFNEDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEvARSPEDFARLLRDEGVTVLNQTPSAFY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2818 TM------DPTAVPSLRVIAAGGEAVPQPIVDRWA-----PATELHNLYGPTETTIGITI----SSAMRPGDPVRLGGPI 2882
Cdd:cd17643    197 QLveaadrDGRDPLALRYVIFGGEALEAAMLRPWAgrfglDRPQLVNMYGITETTVHVTFrpldAADLPAAAASPIGRPL 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2883 GGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTDtggltLEYT 2962
Cdd:cd17643    277 PGLRVYVLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFGGPGSRMYRTGDLARRLPDGE-----LEYL 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2963 GRSDDQVKLRGLRIELGEIEAVLAEHDAV-ESAVVLGVGGSVATALAAYIVPVDGAVEV-SELKAFAGGRLPAYMVPSSF 3040
Cdd:cd17643    352 GRADEQVKIRGFRIELGEIEAALATHPSVrDAAVIVREDEPGDTRLVAYVVADDGAAADiAELRALLKELLPDYMVPARY 431

                          490
                   ....*....|....*....
gi 1827387616 3041 TVIDELPLTPVGKLDKRAL 3059
Cdd:cd17643    432 VPLDALPLTVNGKLDRAAL 450

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

1044-1531

6.72e-125

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 404.03 E-value: 6.72e-125

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1044 AQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:cd17651      3 RQAARTPDAPALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYPAE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGITDASTRARLGEsscewVDLADLEAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVS 1203
Cdd:cd17651     83 RLAFMLADAGPVLVLTHPALAGELAV-----ELVAVTLLDQPGAAAGADAEPDPALDADDLAYVIYTSGSTGRPKGVVMP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1204 HTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAP---QADFAgdALATVLERDEVTdM 1280
Cdd:cd17651    158 HRSLANLVAWQARASSLGPGA----RTLQFAGLGFDVSVQEIFSTLCAGATLVLPPeevRTDPP--ALAAWLDEQRIS-R 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1281 IITPSVL-------ATVDPERAQYVRNLATGGEACPP-ELVERW--SERGRRIFNCYGPTEATV----WATRSRMTAGKP 1346
Cdd:cd17651    231 VFLPTVAlralaehGRPLGVRLAALRYLLTGGEQLVLtEDLREFcaGLPGLRLHNHYGPTETHVvtalSLPGDPAAWPAP 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1347 VTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGePGARMYATGDLVRVAKGGNLE 1426
Cdd:cd17651    311 PPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFV-PGARMYRTGDLARWLPDGELE 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1427 FAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHM 1506
Cdd:cd17651    390 FLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREDRPGEKR---LVAYVVGDPEAPVDAAELRAALATHLPEYM 466

                          490       500
                   ....*....|....*....|....*
gi 1827387616 1507 VPSQAIVIDEIPLTPAGKLDRAALP 1531
Cdd:cd17651    467 VPSAFVLLDALPLTPNGKLDRRALP 491

PRK05691

peptide synthase; Validated

1-994

9.73e-125

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 444.61 E-value: 9.73e-125

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtS 80
Cdd:PRK05691  2214 LSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGAYVPLDPEYPLERLHYMIEDSGIGLLL--S 2291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEA-EARSRFDDIVDVHVLDISSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDL 159
Cdd:PRK05691  2292 DRALfEALGELPAGVARWCLEDDAAALAAYSDAPLPFLSLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFGM 2371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLgAGVGELTS 239
Cdd:PRK05691  2372 RADDCELHFYSINFDAASERLLVPLLCGARVVLRAQGQW-GAEEICQLIREQQVSILGFTPSYGSQLAQWL-AGQGEQLP 2449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEaSIVVTI-----HRVTQDDRVIPIGtptRRVSARV---LDAALR 311
Cdd:PRK05691  2450 VRMCITGGEALTGEHLQRIRQAFAPQLFFNAYGPTE-TVVMPLaclapEQLEEGAASVPIG---RVVGARVayiLDADLA 2525

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  312 EVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGE 391
Cdd:PRK05691  2526 LVPQGATGELYVGGAGLAQGYHDRPGLTAERFVADPFAADGGRLYRTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGE 2605

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  392 VEAALAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVDTVA------ATTAEL---LPEYMRPSAWVRLDAMPLSRSGK 462
Cdd:PRK05691  2606 IESRLLEHPAVREAVVLALDTPSGKQLAGYLVSAVAGQDDEAqaalreALKAHLkqqLPDYMVPAHLILLDSLPLTANGK 2685

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  463 VDRRLL--PEPEIAPTLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARvSKELGVDVSVRDVFE 540
Cdd:PRK05691  2686 LDRRALpaPDPELNRQAYQAPRSELEQQLAQIWREVLNVERVGLGDNFFELGGDSILSIQVVSR-ARQLGIHFSPRDLFQ 2764

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  541 SPSVRGLvhAVSGRGSALPSVKRiEPRPERLPLSRAQRrmWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVER 620
Cdd:PRK05691  2765 HQTVQTL--AAVATHSEAAQAEQ-GPLQGASGLTPIQH--WFFDSPVPQPQHWNQALLLEPRQALDPALLEQALQALVEH 2839

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  621 HEVLRTVYPSVGAAPVQDVLPvaVAREQLDWR----EADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLH-VALTMHH 695
Cdd:PRK05691  2840 HDALRLRFSQADGRWQAEYRA--VTAQELLWQvtvaDFAECAALFADAQRSLDLQQGPLLRALLVDGPQGQQrLLLAIHH 2917

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  696 IAMDGQSIPVLARDLMSAYAARAEGRTGGLPVLDVQYADYALWQQSVLGdaddeTSVLGEQLSHWRRVLAGLPAvtDLPM 775
Cdd:PRK05691  2918 LVVDGVSWRVLLEDLQALYRQLSAGAEPALPAKTSAFRDWAARLQAYAG-----SESLREELGWWQAQLGGPRA--ELPC 2990

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  776 DRPRPAVLGTAGATVTVEFDddlADRVDVL------ARSNTMTGFMVTeaAFAATVARLASTTDVVIGTPVAGR----ND 845
Cdd:PRK05691  2991 DRPQGGNLNRHAQTVSVRLD---AERTRQLlqqapaAYRTQVNDLLLT--ALARVLCRWSGQPSVLVQLEGHGRealfDD 3065

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  846 PALEELIGMFVNTLLLRTQ------VDPGHSVGDLLGNVRTT--------VLDAFANDQVQfdELIEALaperssshqPL 911
Cdd:PRK05691  3066 IDLTRSVGWFTSAYPLRLTpapgddAARGESIKAIKEQLRAVphkglgygVLRYLADAAVR--EAMAAL---------PQ 3134

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  912 AQIAFTYTEPTVN--DVAGL-----EASGIQAAPvdtgvvNAKFDLTVAVRARSGGTPMAADFIYATDLFDESTVKRFAE 984
Cdd:PRK05691  3135 APITFNYLGQFDQsfASDALfrpldEPAGPAHDP------DAPLPNELSVDGQVYGGELVLRWTYSAERYDEQTIAELAE 3208

                         1050
                   ....*....|
gi 1827387616  985 VYRRVLQAIV 994
Cdd:PRK05691  3209 AYLAELQALI 3218

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

2579-3060

4.81e-124

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 399.82 E-value: 4.81e-124

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd17649      1 PDAVALVFG-DQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYM 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLSVlasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevTAANLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd17649     80 LEDSGAGLLLTH------------------------------------------HPRQLAYVIYTSGSTGTPKGVAVSHG 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGG-EVLERFIAEHGATHTFLTPSVLS 2817
Cdd:cd17649    118 PLAAHCQATAERYGLTPGDRELQFASFNFDGAHEQLLPPLICGACVVLRPDELWASaDELAEMVRELGVTVLDLPPAYLQ 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2818 TM-------DPTAVPSLRVIAAGGEAVPQPIVDRWAPATE-LHNLYGPTETTIGITI----SSAMRPGDPVRLGGPIGGV 2885
Cdd:cd17649    198 QLaeeadrtGDGRPPSLRLYIFGGEALSPELLRRWLKAPVrLFNAYGPTEATVTPLVwkceAGAARAGASMPIGRPLGGR 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2886 DLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTdtgglTLEYTGRS 2965
Cdd:cd17649    278 SAYILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERFVPDPFGAPGSRLYRTGDLARWRDDG-----VIEYLGRV 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2966 DDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVE---VSELKAFAGGRLPAYMVPSSFTV 3042
Cdd:cd17649    353 DHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGAGGKQLVAYVVLRAAAAQpelRAQLRTALRASLPDYMVPAHLVF 432

                          490
                   ....*....|....*...
gi 1827387616 3043 IDELPLTPVGKLDKRALP 3060
Cdd:cd17649    433 LARLPLTPNGKLDRKALP 450

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

1050-1531

8.08e-123

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 396.35 E-value: 8.08e-123

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17649      1 PDAVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITdastrarlgesscewvdladleaeaESGDditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd17649     81 EDSGAGLLLT-------------------------HHPR--------------QLAYVIYTSGSTGTPKGVAVSHGPLAA 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAG-DALATVLERDEVTDMIITPS--- 1285
Cdd:cd17649    122 HCQATAERYGLTPGD----RELQFASFNFDGAHEQLLPPLICGACVVLRPDELWASaDELAEMVRELGVTVLDLPPAylq 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1286 ----VLATVDPERAQYVRNLATGGEACPPELVERWSERGRRIFNCYGPTEATV----WATRSRMTAGKP-VTIGKPVDGF 1356
Cdd:cd17649    198 qlaeEADRTGDGRPPSLRLYIFGGEALSPELLRRWLKAPVRLFNAYGPTEATVtplvWKCEAGAARAGAsMPIGRPLGGR 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1357 TVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVK 1436
Cdd:cd17649    278 SAYILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERFVPDPFGAPGSRLYRTGDLARWRDDGVIEYLGRVDHQVK 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1437 INGQRVELGEIEAVLDAQPGVAQSVVVgVESTRGGrkhTEVVAYLVAKPGATidSAAVLDEAAQHLAA----HMVPSQAI 1512
Cdd:cd17649    358 IRGFRIELGEIEAALLEHPGVREAAVV-ALDGAGG---KQLVAYVVLRAAAA--QPELRAQLRTALRAslpdYMVPAHLV 431

                          490
                   ....*....|....*....
gi 1827387616 1513 VIDEIPLTPAGKLDRAALP 1531
Cdd:cd17649    432 FLARLPLTPNGKLDRKALP 450

LCL_NRPS

cd19538

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; ...

570-997

1.42e-122

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.

Pssm-ID: 380461 [Multi-domain] Cd Length: 432 Bit Score: 395.09 E-value: 1.42e-122

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVAVAREQL 649
Cdd:cd19538      1 EIPLSFAQRRLWFLHQLEGPSATYNIPLVIKLKGKLDVQALQQALYDVVERHESLRTVFPEEDGVPYQLILEEDEATPKL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  650 DWREAD--SVESLVRSTTE-GFDVSTQMPLRGRFHRDGAGLHVA-LTMHHIAMDGQSIPVLARDLMSAYAARAEGRTGGL 725
Cdd:cd19538     81 EIKEVDeeELESEINEAVRyPFDLSEEPPFRATLFELGENEHVLlLLLHHIAADGWSLAPLTRDLSKAYRARCKGEAPEL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  726 PVLDVQYADYALWQQSVLGDADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRVDVL 805
Cdd:cd19538    161 APLPVQYADYALWQQELLGDESDPDSLIARQLAYWKKQLAGLPDEIELPTDYPRPAESSYEGGTLTFEIDSELHQQLLQL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  806 ARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQV--DPghSVGDLLGNVRTTVL 883
Cdd:cd19538    241 AKDNNVTLFMVLQAGFAALLTRLGAGTDIPIGSPVAGRNDDSLEDLVGFFVNTLVLRTDTsgNP--SFRELLERVKETNL 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  884 DAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYT---EPtvndvaGLEASGIQAAPVDTGVVNAKFDLTVAVRARSG- 959
Cdd:cd19538    319 EAYEHQDIPFERLVEALNPTRSRSRHPLFQIMLALQntpQP------SLDLPGLEAKLELRTVGSAKFDLTFELREQYNd 392

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1827387616  960 GTP--MAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQ 997
Cdd:cd19538    393 GTPngIEGFIEYRTDLFDHETIEALAQRYLLLLESAVENP 432

A_NRPS_Cytc1-like

cd17643

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

1-468

1.68e-120

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 389.75 E-value: 1.68e-120

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvts 80
Cdd:cd17643     13 LTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFILADSGPSLLL--- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd17643     90 -------------------------------------TDPDDLAYVIYTSGSTGRPKGVVVSHANVLALFAATQRWFGFN 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSL 240
Cdd:cd17643    133 EDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEVARSPEDFARLLRDEGVTVLNQTPSAFYQLVEAADRDGRDPLAL 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVR--LPGTRLQNQYGPAEASIVVTIHRVTQDD----RVIPIGTPTRRVSARVLDAALREVP 314
Cdd:cd17643    213 RYVIFGGEALEAAMLRPWAGRfgLDRPQLVNMYGITETTVHVTFRPLDAADlpaaAASPIGRPLPGLRVYVLDADGRPVP 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  315 IGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA 394
Cdd:cd17643    293 PGVVGELYVSGAGVARGYLGRPELTAERFVANPFGGPGSRMYRTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEA 372

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616  395 ALAAAPGVLHAAAAV-VDGPGGQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd17643    373 ALATHPSVRDAAVIVrEDEPGDTRLVAYVVADDgaaADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

2569-3059

1.07e-119

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 386.66 E-value: 1.07e-119

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDP 2648
Cdd:cd17653      1 DAFERIAAAHPDAVAV-ESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2649 DYPAERVASMIEDSGAVLGLSvLASGDlpgqefewmrldddsvaaeiaavpagpitdaerlgevtaaNLAYVIYTSGSTG 2728
Cdd:cd17653     80 KLPSARIQAILRTSGATLLLT-TDSPD----------------------------------------DLAYIIFTSGSTG 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2729 RPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEavggEVLERFIAEHGATH 2808
Cdd:cd17653    119 IPKGVMVPHRGVLNYVSQPPARLDVGPGSRVAQVLSIAFDACIGEIFSTLCNGGTLVLADPS----DPFAHVARTVDALM 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2809 tfLTPSVLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETTIGITISSaMRPGDPVRLGGPIGGVDLM 2888
Cdd:cd17653    195 --STPSILSTLSPQDFPNLKTIFLGGEAVPPSLLDRWSPGRRLYNAYGPTECTISSTMTE-LLPGQPVTIGKPIPNSTCY 271

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2889 VLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTaGQRMYRTGDVVRWTPDtdtGGltLEYTGRSDDQ 2968
Cdd:cd17653    272 ILDADLQPVPEGVVGEICISGVQVARGYLGNPALTASKFVPDPFWP-GSRMYRTGDYGRWTED---GG--LEFLGREDNQ 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2969 VKLRGLRIELGEIEA-VLAEHDAVESAVVLGVGGSvataLAAYIVPVDgaVEVSELKAFAGGRLPAYMVPSSFTVIDELP 3047
Cdd:cd17653    346 VKVRGFRINLEEIEEvVLQSQPEVTQAAAIVVNGR----LVAFVTPET--VDVDGLRSELAKHLPSYAVPDRIIALDSFP 419

                          490
                   ....*....|..
gi 1827387616 3048 LTPVGKLDKRAL 3059
Cdd:cd17653    420 LTANGKVDRKAL 431

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

2567-3059

2.24e-119

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 386.29 E-value: 2.24e-119

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2567 LAELFRAAARRAPDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:cd12115      1 LHDLVEAQAARTPDAIALVCGDE-SLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMIEDSGAVLGLsvlasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgeVTAANLAYVIYTSGS 2726
Cdd:cd12115     80 DPAYPPERLRFILEDAQARLVL-------------------------------------------TDPDDLAYVIYTSGS 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2727 TGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLlatvneGTLAyrpseaVGGEV--------LE 2798
Cdd:cd12115    117 TGRPKGVAIEHRNAAAFLQWAAAAFSAEELAGVLASTSICFDLSVFELF------GPLA------TGGKVvladnvlaLP 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2799 RFIAEHGATHTFLTPSVLSTM-DPTAVP-SLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGITiSSAMRPG 2873
Cdd:cd12115    185 DLPAAAEVTLINTVPSAAAELlRHDALPaSVRVVNLAGEPLPRDLVQRLyarLQVERVVNLYGPSEDTTYST-VAPVPPG 263

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2874 D--PVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGtAGQRMYRTGDVVRWTPD 2951
Cdd:cd12115    264 AsgEVSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYLGRPGLTAERFLPDPFG-PGARLYRTGDLVRWRPD 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2952 tdtgGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVAT-ALAAYIVPVDG-AVEVSELKAFAGG 3029
Cdd:cd12115    343 ----GL-LEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAAGErRLVAYIVAEPGaAGLVEDLRRHLGT 417

                          490       500       510
                   ....*....|....*....|....*....|
gi 1827387616 3030 RLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd12115    418 RLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

5-472

1.17e-117

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 383.22 E-value: 1.17e-117

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtSDGEA 84
Cdd:cd17655     27 ELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPDYPEERIQYILEDSGADILL--TQSHL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   85 EARSRF-DDIVDVHVLDISSPGDADLdeeefAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd17655    105 QPPIAFiGLIDLLDEDTIYHEESENL-----EPVSKSDDLAYVIYTSGSTGKPKGVMIEHRGVVNLVEWANKVIYQGEHL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLaafNEVLGAGVGELTSLRLI 243
Cdd:cd17655    180 RVALFASISFDASVTEIFASLLSGNTLYIVRKETVLDGQALTQYIRQNRITIIDLTPAHL---KLLDAADDSEGLSLKHL 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  244 QTGGEALTPPVARDLMVRL-PGTRLQNQYGPAEASIVVTIHRVTQDDRV---IPIGTPTRRVSARVLDAALREVPIGVPG 319
Cdd:cd17655    257 IVGGEALSTELAKKIIELFgTNPTITNAYGPTETTVDASIYQYEPETDQqvsVPIGKPLGNTRIYILDQYGRPQPVGVAG 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  320 ELYLGGVQLARGYAGRPDLTAERFVADPFgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA 399
Cdd:cd17655    337 ELYIGGEGVARGYLNRPELTAEKFVDDPF-VPGERMYRTGDLARWLPDGNIEFLGRIDHQVKIRGYRIELGEIEARLLQH 415

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616  400 PGVLHAAAAVV-DGPGGQQLVGYLAP-ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPE 472
Cdd:cd17655    416 PDIKEAVVIARkDEQGQNYLCAYIVSeKELPVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKALPEPD 490

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

2566-3060

1.48e-117

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 381.78 E-value: 1.48e-117

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:cd17644      1 CIHQLFEEQVERTPDAVAVVF-EDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGavlgLSVLasgdlpgqefewmrldddsvaaeiaavpagpITDAErlgevtaaNLAYVIYTSG 2725
Cdd:cd17644     80 LDPNYPQERLTYILEDAQ----ISVL-------------------------------LTQPE--------NLAYVIYTSG 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2726 STGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAV-GGEVLERFIAEH 2804
Cdd:cd17644    117 STGKPKGVMIEHQSLVNLSHGLIKEYGITSSDRVLQFASIAFDVAAEEIYVTLLSGATLVLRPEEMRsSLEDFVQYIQQW 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2805 GATHTFLTPS-------VLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWAPAT----ELHNLYGPTETTIGITISSAMRPG 2873
Cdd:cd17644    197 QLTVLSLPPAywhllvlELLLSTIDLPSSLRLVIVGGEAVQPELVRQWQKNVgnfiQLINVYGPTEATIAATVCRLTQLT 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2874 DP----VRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPY-GTAGQRMYRTGDVVRW 2948
Cdd:cd17644    277 ERnitsVPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFnSSESERLYKTGDLARY 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2949 TPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATA-LAAYIVP-VDGAVEVSELKAF 3026
Cdd:cd17644    357 LPDGN-----IEYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKTAVVIVREDQPGNKrLVAYIVPhYEESPSTVELRQF 431

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1827387616 3027 AGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALP 3060
Cdd:cd17644    432 LKAKLPDYMIPSAFVVLEELPLTPNGKIDRRALP 465

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

1050-1530

6.96e-117

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 380.73 E-value: 6.96e-117

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPAlIC--DGtEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:cd05918     13 PDAPA-VCawDG-SLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDPSHPLQRLQE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDastrarlgesscewvdladleaeaesgdditdterngsvRLTNLAYLIYTSGSTGRPKAVGVSHTGI 1207
Cdd:cd05918     91 ILQDTGAKVVLTS---------------------------------------SPSDAAYVIFTSGSTGKPKGVVIEHRAL 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1208 VDFVNSLAKITTGTPedepDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDaLATVLERDEVTDMIITPSVL 1287
Cdd:cd05918    132 STSALAHGRALGLTS----ESRVLQFASYTFDVSILEIFTTLAAGGCLCIPSEEDRLND-LAGFINRLRVTWAFLTPSVA 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1288 ATVDPERAQYVRNLATGGEACPPELVERWSERgRRIFNCYGPTEATVWATRSRMTAG-KPVTIGKPVDGfTVRVLDGRLH 1366
Cdd:cd05918    207 RLLDPEDVPSLRTLVLGGEALTQSDVDTWADR-VRLINAYGPAECTIAATVSPVVPStDPRNIGRPLGA-TCWVVDPDNH 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1367 E--VPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPF------GEPGARMYATGDLVRVAKGGNLEFAGRADHQVKIN 1438
Cdd:cd05918    285 DrlVPIGAVGELLIEGPILARGYLNDPEKTAAAFIEDPAwlkqegSGRGRRLYRTGDLVRYNPDGSLEYVGRKDTQVKIR 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1439 GQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVAYLVAKPGATIDS-----------------AAVLDEAAQH 1501
Cdd:cd05918    365 GQRVELGEIEHHLRQSLPGAKEVVVEVVKPKDGSSSPQLVAFVVLDGSSSGSGdgdslflepsdefralvAELRSKLRQR 444

                          490       500
                   ....*....|....*....|....*....
gi 1827387616 1502 LAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05918    445 LPSYMVPSVFLPLSHLPLTASGKIDRRAL 473

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

1-468

6.99e-117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 380.46 E-value: 6.99e-117

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd12114     13 LTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAILADAGARLVLTDG 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVDVHVLDISSPgdadldeEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd12114     93 PDAQLDVAVFDVLILDLDALAAPA-------PPPPVDVAPDDLAYVIFTSGSTGTPKGVMISHRAALNTILDINRRFAVG 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSL 240
Cdd:cd12114    166 PDDRVLALSSLSFDLSVYDIFGALSAGATLVLPDEARRRDPAHWAELIERHGVTLWNSVPALLEMLLDVLEAAQALLPSL 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASI---VVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:cd12114    246 RLVLLSGDWIPLDLPARLRALAPDARLISLGGATEASIwsiYHPIDEVPPDWRSIPYGRPLANQRYRVLDPRGRDCPDWV 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPfgePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA 397
Cdd:cd12114    326 PGELWIGGRGVALGYLGDPELTAARFVTHP---DGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQ 402

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616  398 AAPGVLHAAAAVVDGPGGQQLVGYLAPAD----VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd12114    403 AHPGVARAVVVVLGDPGGKRLAAFVVPDNdgtpIAPDALRAFLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477

A_NRPS_Cytc1-like

cd17643

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

1050-1530

1.40e-116

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 378.57 E-value: 1.40e-116

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17643      1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAStrarlgesscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGivd 1209
Cdd:cd17643     81 ADSGPSLLLTDPD----------------------------------------DLAYVIYTSGSTGRPKGVVVSHAN--- 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 fVNSLAKITTGTPEDEPDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQA-DFAGDALATVLERDEVTDMIITPS--- 1285
Cdd:cd17643    118 -VLALFAATQRWFGFNEDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEvARSPEDFARLLRDEGVTVLNQTPSafy 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1286 VLATVDPERAQYVRNLAT---GGEACPPELVERWSER----GRRIFNCYGPTEATVWATRSRMTA-----GKPVTIGKPV 1353
Cdd:cd17643    197 QLVEAADRDGRDPLALRYvifGGEALEAAMLRPWAGRfgldRPQLVNMYGITETTVHVTFRPLDAadlpaAAASPIGRPL 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1354 DGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADH 1433
Cdd:cd17643    277 PGLRVYVLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFGGPGSRMYRTGDLARRLPDGELEYLGRADE 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1434 QVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIV 1513
Cdd:cd17643    357 QVKIRGFRIELGEIEAALATHPSVRDAAVIVREDEPGD---TRLVAYVVADDGAAADIAELRALLKELLPDYMVPARYVP 433

                          490
                   ....*....|....*..
gi 1827387616 1514 IDEIPLTPAGKLDRAAL 1530
Cdd:cd17643    434 LDALPLTVNGKLDRAAL 450

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

1050-1530

2.31e-115

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 374.34 E-value: 2.31e-115

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17653     11 PDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAKLPSARIQAIL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAStrarlgesscewvdladleaeaesGDDitdterngsvrltnLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd17653     91 RTSGATLLLTTDS------------------------PDD--------------LAYIIFTSGSTGIPKGVMVPHRGVLN 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FV-NSLAKITTGtpedePDTRILHVASPSFDASMFEMAWAIPAGHTLVIA-PQADFAGDAlatvlerDEVTDMIITPSVL 1287
Cdd:cd17653    133 YVsQPPARLDVG-----PGSRVAQVLSIAFDACIGEIFSTLCNGGTLVLAdPSDPFAHVA-------RTVDALMSTPSIL 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1288 ATVDPERAQYVRNLATGGEACPPELVERWSErGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHE 1367
Cdd:cd17653    201 STLSPQDFPNLKTIFLGGEAVPPSLLDRWSP-GRRLYNAYGPTECTISSTMTELLPGQPVTIGKPIPNSTCYILDADLQP 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1368 VPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEI 1447
Cdd:cd17653    280 VPEGVVGEICISGVQVARGYLGNPALTASKFVPDPF-WPGSRMYRTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEI 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1448 EA-VLDAQPGVAQSVVVGVESTrggrkhteVVAYLVAkpgATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:cd17653    359 EEvVLQSQPEVTQAAAIVVNGR--------LVAFVTP---ETVDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVD 427


                   ....
gi 1827387616 1527 RAAL 1530
Cdd:cd17653    428 RKAL 431

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

1042-1530

5.99e-115

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 373.58 E-value: 5.99e-115

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1042 VLAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYP 1121
Cdd:cd12115      5 VEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDPAYP 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1122 ADRIAYMLEDSGATVGITDAstrarlgesscewvdladleaeaesgdditdterngsvrlTNLAYLIYTSGSTGRPKAVG 1201
Cdd:cd12115     85 PERLRFILEDAQARLVLTDP----------------------------------------DDLAYVIYTSGSTGRPKGVA 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1202 VSHTGIVDFVNSLAKITTGtpedEPDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALAtvleRDEVTDMI 1281
Cdd:cd12115    125 IEHRNAAAFLQWAAAAFSA----EELAGVLASTSICFDLSVFELFGPLATGGKVVLADNVLALPDLPA----AAEVTLIN 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1282 ITPSVLAT-----VDPERAQYVrNLAtgGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRMTAG--KPVTIGKP 1352
Cdd:cd12115    197 TVPSAAAEllrhdALPASVRVV-NLA--GEPLPRDLVQRLYARlqVERVVNLYGPSEDTTYSTVAPVPPGasGEVSIGRP 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1353 VDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGePGARMYATGDLVRVAKGGNLEFAGRAD 1432
Cdd:cd12115    274 LANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYLGRPGLTAERFLPDPFG-PGARLYRTGDLVRWRPDGLLEFLGRAD 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1433 HQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAI 1512
Cdd:cd12115    353 NQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAAGERR---LVAYIVAEPGAAGLVEDLRRHLGTRLPAYMVPSRFV 429

                          490
                   ....*....|....*...
gi 1827387616 1513 VIDEIPLTPAGKLDRAAL 1530
Cdd:cd12115    430 RLDALPLTPNGKIDRSAL 447

DCL_NRPS

cd19543

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

2106-2535

9.01e-114

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor; The DCL-type Condensation (C) domain catalyzes the condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. This domain is D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L)); this is in contrast with the standard LCL domains which catalyze peptide bond formation between two L-amino acids, and the restriction of ribosomes to use only L-amino acids. C domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains in addition to the LCL- and DCL-types such as starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 369.22 E-value: 9.01e-114

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2106 VWPMTPLQQGLFFQADLantvaDHDAiDVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAE 2185
Cdd:cd19543      1 IYPLSPMQEGMLFHSLL-----DPGS-GAYVEQMVITLEGPLDPDRFRAAWQAVVDRHPILRTSFVWEGLGEPLQVVLKD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2186 VTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGA-ELVVTNHHLLIDGWSSPLVLADLLSL 2264
Cdd:cd19543     75 RKLPWRELDLSHLSEAEQEAELEALAEEDRERGFDLARAPLMRLTLIRLGDDRyRLVWSFHHILLDGWSLPILLKELFAI 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2265 Y-ATGQTFTGSLPGTsgRDFADHARAVATADVEAGIAAWREVLAPVTEPTLVAPGHEPSADAP--PRDHQFSIDVKVTER 2341
Cdd:cd19543    155 YaALGEGQPPSLPPV--RPYRDYIAWLQRQDKEAAEAYWREYLAGFEEPTPLPKELPADADGSyePGEVSFELSAELTAR 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2342 LEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQ 2421
Cdd:cd19543    233 LQELARQHGVTLNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAELPGIETMVGLFINTLPVRVRLDPDQTVLELLKDLQ 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2422 NDKVKVLDHQQIGLPRLVAQTGLP-ALFDTLAVYESFPVnVDSVAGIDasSAGGLKLVGAKTSDATHYPLNLSASrRGAE 2500
Cdd:cd19543    313 AQQLELREHEYVPLYEIQAWSEGKqALFDHLLVFENYPV-DESLEEEQ--DEDGLRITDVSAEEQTNYPLTVVAI-PGEE 388

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1827387616 2501 LALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19543    389 LTIKLSYDAEVFDEATIERLLGHLRRVLEQVAANP 423

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

1-468

1.20e-113

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 369.72 E-value: 1.20e-113

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvts 80
Cdd:cd12115     25 LTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDPAYPPERLRFILEDAQARLVL--- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd12115    102 -------------------------------------TDPDDLAYVIYTSGSTGRPKGVAIEHRNAAAFLQWAAAAFSAE 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEpgrhgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAgvgeLTSL 240
Cdd:cd12115    145 ELAGVLASTSICFDLSVFELFGPLATGGKVVLAD-----NVLALPDLPAAAEVTLINTVPSAAAELLRHDAL----PASV 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVT-QDDRVIPIGTPTRRVSARVLDAALREVPIGVPG 319
Cdd:cd12115    216 RVVNLAGEPLPRDLVQRLYARLQVERVVNLYGPSEDTTYSTVAPVPpGASGEVSIGRPLANTQAYVLDRALQPVPLGVPG 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  320 ELYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA 399
Cdd:cd12115    296 ELYIGGAGVARGYLGRPGLTAERFLPDPFG-PGARLYRTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSI 374

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  400 PGVlHAAAAVV--DGPGGQQLVGYL---APADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd12115    375 PGV-REAVVVAigDAAGERRLVAYIvaePGAAGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

2579-3060

2.77e-113

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 369.04 E-value: 2.77e-113

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGAgARLTYRELDEASDRLARWLIGRGVG-PERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVAS 2657
Cdd:cd17648      1 PDRVAVVYGD-KRLTYRELNERANRLAHYLLSVAEIrPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQF 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2658 MIEDSGAVLglsVLAsgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevTAANLAYVIYTSGSTGRPKGVAVTH 2737
Cdd:cd17648     80 ILEDTGARV---VIT----------------------------------------NSTDLAYAIYTSGTTGKPKGVLVEH 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2738 SGLANFARQESDR--LNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGG-EVLERFIAEHGATHTFLTPS 2814
Cdd:cd17648    117 GSVVNLRTSLSERyfGRDNGDEAVLFFSNYVFDFFVEQMTLALLNGQKLVVPPDEMRFDpDRFYAYINREKVTYLSGTPS 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2815 VLSTMDPTAVPSLRVIAAGGEAVPQPIVD--RWAPATELHNLYGPTETTIgITISSAMRPGDPVR--LGGPIGGVDLMVL 2890
Cdd:cd17648    197 VLQQYDLARLPHLKRVDAAGEEFTAPVFEklRSRFAGLIINAYGPTETTV-TNHKRFFPGDQRFDksLGRPVRNTKCYVL 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2891 DERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQ-------RMYRTGDVVRWTPDTDtggltLEYTG 2963
Cdd:cd17648    276 NDAMKRVPVGAVGELYLGGDGVARGYLNRPELTAERFLPNPFQTEQErargrnaRLYKTGDLVRWLPSGE-----LEYLG 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2964 RSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVL------GVGGSVATALAAYIVPVDGAVEVSELKAFAGGRLPAYMVP 3037
Cdd:cd17648    351 RNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVakedasQAQSRIQKYLVGYYLPEPGHVPESDLLSFLRAKLPRYMVP 430

                          490       500
                   ....*....|....*....|...
gi 1827387616 3038 SSFTVIDELPLTPVGKLDKRALP 3060
Cdd:cd17648    431 ARLVRLEGIPVTINGKLDVRALP 453

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

2579-3060

1.86e-112

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 367.95 E-value: 1.86e-112

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGAgARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd17656      2 PDAVAVVFEN-QKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLSVLASGDLPGQEFEWMRLDDDSVAAEiaavpagpitDAERLGEVTAAN-LAYVIYTSGSTGRPKGVAVTH 2737
Cdd:cd17656     81 MLDSGVRVVLTQRHLKSKLSFNKSTILLEDPSISQE----------DTSNIDYINNSDdLLYIIYTSGTTGKPKGVQLEH 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2738 SGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLaYRPSEAVGGEV--LERFIAEHGATHTFLTPSV 2815
Cdd:cd17656    151 KNMVNLLHFEREKTNINFSDKVLQFATCSFDVCYQEIFSTLLSGGTL-YIIREETKRDVeqLFDLVKRHNIEVVFLPVAF 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2816 LSTM--DPTAVPSL-----RVIAAGGE-AVPQPIVDRW-APATELHNLYGPTETTIGITISsaMRPGDPVRL----GGPI 2882
Cdd:cd17656    230 LKFIfsEREFINRFptcvkHIITAGEQlVITNEFKEMLhEHNVHLHNHYGPSETHVVTTYT--INPEAEIPElppiGKPI 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2883 GGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgTAGQRMYRTGDVVRWTPDTDtggltLEYT 2962
Cdd:cd17656    308 SNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPF-DPNERMYRTGDLARYLPDGN-----IEFL 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2963 GRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATA-LAAYIVPVDgAVEVSELKAFAGGRLPAYMVPSSFT 3041
Cdd:cd17656    382 GRADHQVKIRGYRIELGEIEAQLLNHPGVSEAVVLDKADDKGEKyLCAYFVMEQ-ELNISQLREYLAKQLPEYMIPSFFV 460

                          490
                   ....*....|....*....
gi 1827387616 3042 VIDELPLTPVGKLDKRALP 3060
Cdd:cd17656    461 PLDQLPLTPNGKVDRKALP 479

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

1-468

1.63e-110

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 362.25 E-value: 1.63e-110

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd05918     25 LTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDPSHPLQRLQEILQDTGAKVVLTSS 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagptrPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd05918    105 ---------------------------------------PSDAAYVIFTSGSTGKPKGVVIEHRALSTSALAHGRALGLT 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIA-EPGRHGDpvhLADLIRRHGVTVIHFVPAMLAAFNEvlgagvGELTS 239
Cdd:cd05918    146 SESRVLQFASYTFDVSILEIFTTLAAGGCLCIPsEEDRLND---LAGFINRLRVTWAFLTPSVARLLDP------EDVPS 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPpvaRDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTrRVSARVLDAA--LREVPIGV 317
Cdd:cd05918    217 LRTLVLGGEALTQ---SDVDTWADRVRLINAYGPAECTIAATVSPVVPSTDPRNIGRPL-GATCWVVDPDnhDRLVPIGA 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADPF------GEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGE 391
Cdd:cd05918    293 VGELLIEGPILARGYLNDPEKTAAAFIEDPAwlkqegSGRGRRLYRTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGE 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  392 VEAALAAAPGVLHAAAAVV----DGPGGQQLVGYLA-----------------PADVDVDTVAATTAEL---LPEYMRPS 447
Cdd:cd05918    373 IEHHLRQSLPGAKEVVVEVvkpkDGSSSPQLVAFVVldgsssgsgdgdslflePSDEFRALVAELRSKLrqrLPSYMVPS 452

                          490       500
                   ....*....|....*....|.
gi 1827387616  448 AWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05918    453 VFLPLSHLPLTASGKIDRRAL 473

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

5-469

4.99e-110

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 360.21 E-value: 4.99e-110

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtsdgea 84
Cdd:cd17644     30 ELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLDPNYPQERLTYILEDAQISVLL------- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   85 earsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDV 164
Cdd:cd17644    103 ---------------------------------TQPENLAYVIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEYGITSSDR 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  165 FLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAF-NEVLGAGVGELTSLRLI 243
Cdd:cd17644    150 VLQFASIAFDVAAEEIYVTLLSGATLVLRPEEMRSSLEDFVQYIQQWQLTVLSLPPAYWHLLvLELLLSTIDLPSSLRLV 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  244 QTGGEALTPPVARDLM-VRLPGTRLQNQYGPAEASIVVTIHRVTQDDRV----IPIGTPTRRVSARVLDAALREVPIGVP 318
Cdd:cd17644    230 IVGGEAVQPELVRQWQkNVGNFIQLINVYGPTEATIAATVCRLTQLTERnitsVPIGRPIANTQVYILDENLQPVPVGVP 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GELYLGGVQLARGYAGRPDLTAERFVADPF-GEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA 397
Cdd:cd17644    310 GELHIGGVGLARGYLNRPELTAEKFISHPFnSSESERLYKTGDLARYLPDGNIEYLGRIDNQVKIRGFRIELGEIEAVLS 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  398 AAPGVlhAAAAVV---DGPGGQQLVGYLAPAdvdvDTVAATTAEL-------LPEYMRPSAWVRLDAMPLSRSGKVDRRL 467
Cdd:cd17644    390 QHNDV--KTAVVIvreDQPGNKRLVAYIVPH----YEESPSTVELrqflkakLPDYMIPSAFVVLEELPLTPNGKIDRRA 463


                   ..
gi 1827387616  468 LP 469
Cdd:cd17644    464 LP 465

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

1050-1531

1.94e-106

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 349.39 E-value: 1.94e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARG-VSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYM 1128
Cdd:cd17648      1 PDRVAVVYGDKRLTYRELNERANRLAHYLLSVAeIRPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1129 LEDSGATVGITDAstrarlgesscewvdladleaeaesgdditdterngsvrlTNLAYLIYTSGSTGRPKAVGVSHTGIV 1208
Cdd:cd17648     81 LEDTGARVVITNS----------------------------------------TDLAYAIYTSGTTGKPKGVLVEHGSVV 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1209 DFVNSLAKITTGtpEDEPDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQAD-FAGDALATVLERDEVTDMIITPSVL 1287
Cdd:cd17648    121 NLRTSLSERYFG--RDNGDEAVLFFSNYVFDFFVEQMTLALLNGQKLVVPPDEMrFDPDRFYAYINREKVTYLSGTPSVL 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1288 ATVDPERAQYVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPV--TIGKPVDGFTVRVLDGR 1364
Cdd:cd17648    199 QQYDLARLPHLKRVDAAGEEFTAPVFEKLRSRfAGLIINAYGPTETTVTNHKRFFPGDQRFdkSLGRPVRNTKCYVLNDA 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1365 LHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPG-------ARMYATGDLVRVAKGGNLEFAGRADHQVKI 1437
Cdd:cd17648    279 MKRVPVGAVGELYLGGDGVARGYLNRPELTAERFLPNPFQTEQerargrnARLYKTGDLVRWLPSGELEYLGRNDFQVKI 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1438 NGQRVELGEIEAVLDAQPGVAQSVVVGVE----STRGGRKHteVVAYLVAKPGaTIDSAAVLDEAAQHLAAHMVPSQAIV 1513
Cdd:cd17648    359 RGQRIEPGEVEAALASYPGVRECAVVAKEdasqAQSRIQKY--LVGYYLPEPG-HVPESDLLSFLRAKLPRYMVPARLVR 435

                          490
                   ....*....|....*...
gi 1827387616 1514 IDEIPLTPAGKLDRAALP 1531
Cdd:cd17648    436 LEGIPVTINGKLDVRALP 453

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

2575-3059

2.17e-106

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 349.24 E-value: 2.17e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAER 2654
Cdd:cd05945      1 AAANPDRPAV-VEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAER 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2655 VASMIEDSGAVLglsVLASGDlpgqefewmrldddsvaaeiaavpagpitdaerlgevtaaNLAYVIYTSGSTGRPKGVA 2734
Cdd:cd05945     80 IREILDAAKPAL---LIADGD----------------------------------------DNAYIIFTSGSTGRPKGVQ 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2735 VTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEV-LERFIAEHGATHTFLTP 2813
Cdd:cd05945    117 ISHDNLVSFTNWMLSDFPLGPGDVFLNQAPFSFDLSVMDLYPALASGATLVPVPRDATADPKqLFRFLAEHGITVWVSTP 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2814 SVLS------TMDPTAVPSLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGIT---ISSAMRPG-DPVRLGG 2880
Cdd:cd05945    197 SFAAmcllspTFTPESLPSLRHFLFCGEVLPHKTARALqqrFPDARIYNTYGPTEATVAVTyieVTPEVLDGyDRLPIGY 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2881 PIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPygtaGQRMYRTGDVVRWTPDtdtgGLtLE 2960
Cdd:cd05945    277 AKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAFFPDE----GQRAYRTGDLVRLEAD----GL-LF 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2961 YTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG-GSVATALAAYIVPVDGAVEV--SELKAFAGGRLPAYMVP 3037
Cdd:cd05945    348 YRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYkGEKVTELIAFVVPKPGAEAGltKAIKAELAERLPPYMIP 427

                          490       500
                   ....*....|....*....|..
gi 1827387616 3038 SSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05945    428 RRFVYLDELPLNANGKIDRKAL 449

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

1039-1540

5.13e-106

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 347.95 E-value: 5.13e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1039 LIDVLAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVD 1117
Cdd:COG0318      1 LADLLRRAaARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1118 PAYPADRIAYMLEDSGATVGITdastrarlgesscewvdladleaeaesgdditdterngsvrltnlAYLIYTSGSTGRP 1197
Cdd:COG0318     81 PRLTAEELAYILEDSGARALVT---------------------------------------------ALILYTSGTTGRP 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1198 KAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPA-GHTLVIAPqaDFAGDALATVLERDE 1276
Cdd:COG0318    116 KGVMLTHRNLLANAAAIAAALGLTPGD----VVLVALPLFHVFGLTVGLLAPLLaGATLVLLP--RFDPERVLELIERER 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1277 VTDMIITPSVLATV--DPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAG--KPV 1347
Cdd:COG0318    190 VTVLFGVPTMLARLlrHPEFARYdlssLRLVVSGGAPLPPELLERFEERfGVRIVEGYGLTETSPVVTVNPEDPGerRPG 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1348 TIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFvADPFgepgarmYATGDLVRVAKGGNLEF 1427
Cdd:COG0318    270 SVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAF-RDGW-------LRTGDLGRLDEDGYLYI 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1428 AGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMV 1507
Cdd:COG0318    342 VGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGE---RVVAFVVLRPGAELDAEELRAFLRERLARYKV 418

                          490       500       510
                   ....*....|....*....|....*....|...
gi 1827387616 1508 PSQAIVIDEIPLTPAGKLDRAALPEPHAPEPAE 1540
Cdd:COG0318    419 PRRVEFVDELPRTASGKIDRRALRERYAAGALE 451

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

2579-3059

3.16e-105

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 345.61 E-value: 3.16e-105

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGAgARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd17650      1 PDAIAVSDAT-RQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYM 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLSvlasgdLPGqefewmrldddsvaaeiaavpagpitdaerlgevtaaNLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd17650     80 LEDSGAKLLLT------QPE-------------------------------------DLAYVIYTSGTTGKPKGVMVEHR 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPV-VLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEV-LERFIAEHGATHTFLTPS-V 2815
Cdd:cd17650    117 NVAHAAHAWRREYELDSFPVrLLQMASFSFDVFAGDFARSLLNGGTLVICPDEVKLDPAaLYDLILKSRITLMESTPAlI 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2816 LSTMDPTA-----VPSLRVIAAGGEAVPQP----IVDRWAPATELHNLYGPTETTIGITISSAMRPGDP----VRLGGPI 2882
Cdd:cd17650    197 RPVMAYVYrngldLSAMRLLIVGSDGCKAQdfktLAARFGQGMRIINSYGVTEATIDSTYYEEGRDPLGdsanVPIGRPL 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2883 GGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGtAGQRMYRTGDVVRWTPDTdtgglTLEYT 2962
Cdd:cd17650    277 PNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFA-PGERMYRTGDLARWRADG-----NVELL 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2963 GRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVL---GVGGSvaTALAAYIVPVDgAVEVSELKAFAGGRLPAYMVPSS 3039
Cdd:cd17650    351 GRVDHQVKIRGFRIELGEIESQLARHPAIDEAVVAvreDKGGE--ARLCAYVVAAA-TLNTAELRAFLAKELPSYMIPSY 427

                          490       500
                   ....*....|....*....|
gi 1827387616 3040 FTVIDELPLTPVGKLDKRAL 3059
Cdd:cd17650    428 YVQLDALPLTPNGKVDRRAL 447

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

1050-1530

2.06e-104

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 343.30 E-value: 2.06e-104

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17650      1 PDAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAstrarlgesscewvdladleaeaesgdditdterngsvrlTNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd17650     81 EDSGAKLLLTQP----------------------------------------EDLAYVIYTSGTTGKPKGVMVEHRNVAH 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTgtpEDEPDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQ-ADFAGDALATVLERDEVTDMIITPSVLA 1288
Cdd:cd17650    121 AAHAWRREYE---LDSFPVRLLQMASFSFDVFAGDFARSLLNGGTLVICPDeVKLDPAALYDLILKSRITLMESTPALIR 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1289 TV------DPERAQYVRNLATGGEACPPE----LVERWSERgRRIFNCYGPTEATVWAT-----RSRMTAGKPVTIGKPV 1353
Cdd:cd17650    198 PVmayvyrNGLDLSAMRLLIVGSDGCKAQdfktLAARFGQG-MRIINSYGVTEATIDSTyyeegRDPLGDSANVPIGRPL 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1354 DGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGePGARMYATGDLVRVAKGGNLEFAGRADH 1433
Cdd:cd17650    277 PNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFA-PGERMYRTGDLARWRADGNVELLGRVDH 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1434 QVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGgrkHTEVVAYLVakPGATIDSAAVLDEAAQHLAAHMVPSQAIV 1513
Cdd:cd17650    356 QVKIRGFRIELGEIESQLARHPAIDEAVVAVREDKGG---EARLCAYVV--AAATLNTAELRAFLAKELPSYMIPSYYVQ 430

                          490
                   ....*....|....*..
gi 1827387616 1514 IDEIPLTPAGKLDRAAL 1530
Cdd:cd17650    431 LDALPLTPNGKVDRRAL 447

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

1050-1531

5.79e-104

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 342.88 E-value: 5.79e-104

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17644     14 PDAVAVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLDPNYPQERLTYIL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAStrarlgesscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd17644     94 EDAQISVLLTQPE----------------------------------------NLAYVIYTSGSTGKPKGVMIEHQSLVN 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAP-QADFAGDALATVLERDEVTDMIITPS--- 1285
Cdd:cd17644    134 LSHGLIKEYGITSSD----RVLQFASIAFDVAAEEIYVTLLSGATLVLRPeEMRSSLEDFVQYIQQWQLTVLSLPPAywh 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1286 ------VLATVD-PERAQYVrnlATGGEACPPELVERWSERGR---RIFNCYGPTEATVWATRSRMTA-----GKPVTIG 1350
Cdd:cd17644    210 llvlelLLSTIDlPSSLRLV---IVGGEAVQPELVRQWQKNVGnfiQLINVYGPTEATIAATVCRLTQlternITSVPIG 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1351 KPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPF-GEPGARMYATGDLVRVAKGGNLEFAG 1429
Cdd:cd17644    287 RPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFnSSESERLYKTGDLARYLPDGNIEYLG 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1430 RADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPS 1509
Cdd:cd17644    367 RIDNQVKIRGFRIELGEIEAVLSQHNDVKTAVVIVREDQPGNKR---LVAYIVPHYEESPSTVELRQFLKAKLPDYMIPS 443

                          490       500
                   ....*....|....*....|..
gi 1827387616 1510 QAIVIDEIPLTPAGKLDRAALP 1531
Cdd:cd17644    444 AFVVLEELPLTPNGKIDRRALP 465

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

1-468

1.18e-103

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 340.44 E-value: 1.18e-103

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTs 80
Cdd:cd17653     23 LTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAKLPSARIQAILRTSGATLLLTT- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd17653    102 -------------------------------------DSPDDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARLDVG 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPgrhgdPVHLADLIRRhgVTVIHFVPAMLAAFNevlgagVGELTSL 240
Cdd:cd17653    145 PGSRVAQVLSIAFDACIGEIFSTLCNGGTLVLADP-----SDPFAHVART--VDALMSTPSILSTLS------PQDFPNL 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 RLIQTGGEALTPPVARDLmvrLPGTRLQNQYGPAEASIVVTIHRVTQDDRViPIGTPTRRVSARVLDAALREVPIGVPGE 320
Cdd:cd17653    212 KTIFLGGEAVPPSLLDRW---SPGRRLYNAYGPTECTISSTMTELLPGQPV-TIGKPIPNSTCYILDADLQPVPEGVVGE 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  321 LYLGGVQLARGYAGRPDLTAERFVADPFgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA-ALAAA 399
Cdd:cd17653    288 ICISGVQVARGYLGNPALTASKFVPDPF-WPGSRMYRTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEIEEvVLQSQ 366

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  400 PGVLHAAAAVVDGpggqQLVGYLAPADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd17653    367 PEVTQAAAIVVNG----RLVAFVTPETVDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKAL 431

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

2569-3060

1.18e-103

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 340.69 E-value: 1.18e-103

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDP 2648
Cdd:cd17645      2 QLFEEQVERTPDHVAVVD-RGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2649 DYPAERVASMIEDSGAVLGLSvlasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevTAANLAYVIYTSGSTG 2728
Cdd:cd17645     81 DYPGERIAYMLADSSAKILLT-------------------------------------------NPDDLAYVIYTSGSTG 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2729 RPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEA-VGGEVLERFIAEHGAT 2807
Cdd:cd17645    118 LPKGVMIEHHNLVNLCEWHRPYFGVTPADKSLVYASFSFDASAWEIFPHLTAGAALHVVPSERrLDLDALNDYFNQEGIT 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2808 HTFLTPSVLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWapatELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDL 2887
Cdd:cd17645    198 ISFLPTGAAEQFMQLDNQSLRVLLTGGDKLKKIERKGY----KLVNNYGPTENTVVATSFEIDKPYANIPIGKPIDNTRV 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2888 MVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTaGQRMYRTGDVVRWTPDtdtGGltLEYTGRSDD 2967
Cdd:cd17645    274 YILDEALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKFIVHPFVP-GERMYRTGDLAKFLPD---GN--IEFLGRLDQ 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2968 QVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-GGSVATALAAYIVPvDGAVEVSELKAFAGGRLPAYMVPSSFTVIDEL 3046
Cdd:cd17645    348 QVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKeDADGRKYLVAYVTA-PEEIPHEELREWLKNDLPDYMIPTYFVHLKAL 426

                          490
                   ....*....|....
gi 1827387616 3047 PLTPVGKLDKRALP 3060
Cdd:cd17645    427 PLTANGKVDRKALP 440

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

1050-1530

6.57e-103

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 340.02 E-value: 6.57e-103

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd12114      1 PDATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDastrarlGESSCEWVDLADLEAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIvd 1209
Cdd:cd12114     81 ADAGARLVLTD-------GPDAQLDVAVFDVLILDLDALAAPAPPPPVDVAPDDLAYVIFTSGSTGTPKGVMISHRAA-- 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 fVNSLAKITTG---TPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAG-DALATVLERDEVT------- 1278
Cdd:cd12114    152 -LNTILDINRRfavGPDD----RVLALSSLSFDLSVYDIFGALSAGATLVLPDEARRRDpAHWAELIERHGVTlwnsvpa 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1279 --DMIITpsvLATVDPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRM----TAGKPVTIG 1350
Cdd:cd12114    227 llEMLLD---VLEAAQALLPSLRLVLLSGDWIPLDLPARLRALapDARLISLGGATEASIWSIYHPIdevpPDWRSIPYG 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1351 KPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPfgePGARMYATGDLVRVAKGGNLEFAGR 1430
Cdd:cd12114    304 RPLANQRYRVLDPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHP---DGERLYRTGDLGRYRPDGTLEFLGR 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1431 ADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVestrGGRKHTEVVAYLVAKPGAT-IDSAAVLDEAAQHLAAHMVPS 1509
Cdd:cd12114    381 RDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVL----GDPGGKRLAAFVVPDNDGTpIAPDALRAFLAQTLPAYMIPS 456

                          490       500
                   ....*....|....*....|.
gi 1827387616 1510 QAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd12114    457 RVIALEALPLTANGKVDRAAL 477

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

2567-3066

2.99e-102

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 337.17 E-value: 2.99e-102

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2567 LAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:COG0318      1 LADLLRRAAARHPDRPALVFG-GRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMIEDSGAVLglsVLAsgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevtaanlAYVIYTSGS 2726
Cdd:COG0318     80 NPRLTAEELAYILEDSGARA---LVT---------------------------------------------ALILYTSGT 111

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2727 TGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEG-TLAYRPSeaVGGEVLERFIAEHG 2805
Cdd:COG0318    112 TGRPKGVMLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHVFGLTVGLLAPLLAGaTLVLLPR--FDPERVLELIERER 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2806 ATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTIGITISSA-MRPGDPV 2876
Cdd:COG0318    190 VTVLFGVPTMLARLlrhpefARYDLSSLRLVVSGGAPLPPELLERFEERFgvRIVEGYGLTETSPVVTVNPEdPGERRPG 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2877 RLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFtANPYgtagqrmYRTGDVVRWTPDtdtGG 2956
Cdd:COG0318    270 SVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAF-RDGW-------LRTGDLGRLDED---GY 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2957 LTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVA-TALAAYIVPVDGA-VEVSELKAFAGGRLPAY 3034
Cdd:COG0318    339 LYI--VGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWgERVVAFVVLRPGAeLDAEELRAFLRERLARY 416

                          490       500       510
                   ....*....|....*....|....*....|..
gi 1827387616 3035 MVPSSFTVIDELPLTPVGKLDKRALPEPVLEA 3066
Cdd:COG0318    417 KVPRRVEFVDELPRTASGKIDRRALRERYAAG 448

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

1-468

5.55e-102

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 336.36 E-value: 5.55e-102

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvts 80
Cdd:cd17650     13 LTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYMLEDSGAKLLL--- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd17650     90 -------------------------------------TQPEDLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELD 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDV-FLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTS 239
Cdd:cd17650    133 SFPVrLLQMASFSFDVFAGDFARSLLNGGTLVICPDEVKLDPAALYDLILKSRITLMESTPALIRPVMAYVYRNGLDLSA 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARDLMVRL-PGTRLQNQYGPAEASIVVTIHRVTQDD----RVIPIGTPTRRVSARVLDAALREVP 314
Cdd:cd17650    213 MRLLIVGSDGCKAQDFKTLAARFgQGMRIINSYGVTEATIDSTYYEEGRDPlgdsANVPIGRPLPNTAMYVLDERLQPQP 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  315 IGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA 394
Cdd:cd17650    293 VGVAGELYIGGAGVARGYLNRPELTAERFVENPFA-PGERMYRTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIES 371

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616  395 ALAAAPGVLHAAAAVVDGPGGQ-QLVGYLAPAD-VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd17650    372 QLARHPAIDEAVVAVREDKGGEaRLCAYVVAAAtLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447

PRK05691

peptide synthase; Validated

2-557

3.83e-98

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 357.17 E-value: 3.83e-98

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:PRK05691  3747 SYAELNRAANRLGHALRAAGVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPLDPGLPAQRLQRIIELSRTPVLVCSAA 3826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEARSRFDDIVDV---HVL---DISSPGDADLDEEEFAGPTrpaNAAFTLFTSGSTGRPKAVVITHRGIANRLAADIE 155
Cdd:PRK05691  3827 CREQARALLDELGCAnrpRLLvweEVQAGEVASHNPGIYSGPD---NLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVP 3903

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  156 QYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPA----MLAAFNEVLG 231
Cdd:PRK05691  3904 YLALSEADVIAQTASQSFDISVWQFLAAPLFGARVEIVPNAIAHDPQGLLAHVQAQGITVLESVPSliqgMLAEDRQALD 3983

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  232 agvgeltSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRV---TQDDRVIPIGTPTRRVSARVLDA 308
Cdd:PRK05691  3984 -------GLRWMLPTGEAMPPELARQWLQRYPQIGLVNAYGPAECSDDVAFFRVdlaSTRGSYLPIGSPTDNNRLYLLDE 4056

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  309 ALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLE 388
Cdd:PRK05691  4057 ALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAFVPHPFGAPGERLYRTGDLARRRSDGVLEYVGRIDHQVKIRGYRIE 4136

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  389 LGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVDTVAA-------TTAElLPEYMRPSAWVRLDAMPLSRSG 461
Cdd:PRK05691  4137 LGEIEARLHEQAEVREAAVAVQEGVNGKHLVGYLVPHQTVLAQGALlerikqrLRAE-LPDYMVPLHWLWLDRLPLNANG 4215

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  462 KVDRRLLPEPEIA---PTLYVPPGNADEETVAGLFAELLGVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDV 538
Cdd:PRK05691  4216 KLDRKALPALDIGqlqSQAYLAPRNELEQTLATIWADVLKVERVGVHDNFFELGGHSLLATQIASRVQKALQRNVPLRAM 4295

                          570
                   ....*....|....*....
gi 1827387616  539 FESPSVRGLVHAVSGRGSA 557
Cdd:PRK05691  4296 FECSTVEELAEYIEGLAGS 4314

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

1050-1530

1.30e-95

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 318.04 E-value: 1.30e-95

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd05945      5 PDRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERIREIL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDastrarlgesscewvdladleaeaesGDDitdterngsvrltnLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd05945     85 DAAKPALLIAD--------------------------GDD--------------NAYIIFTSGSTGRPKGVQISHDNLVS 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAP---QADFAgdALATVLERDEVTDMIITPSV 1286
Cdd:cd05945    125 FTNWMLSDFPLGPGD----VFLNQAPFSFDLSVMDLYPALASGATLVPVPrdaTADPK--QLFRFLAEHGITVWVSTPSF 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1287 --LATVDPERAQyvRNLAT------GGEACPPELVERWSER--GRRIFNCYGPTEATVWATRSRMTAG-----KPVTIGK 1351
Cdd:cd05945    199 aaMCLLSPTFTP--ESLPSlrhflfCGEVLPHKTARALQQRfpDARIYNTYGPTEATVAVTYIEVTPEvldgyDRLPIGY 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1352 PVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFvadpFGEPGARMYATGDLVRVAKGGNLEFAGRA 1431
Cdd:cd05945    277 AKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAF----FPDEGQRAYRTGDLVRLEADGLLFYRGRL 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1432 DHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVEStrgGRKHTEVVAYLVAKPGATI-DSAAVLDEAAQHLAAHMVPSQ 1510
Cdd:cd05945    353 DFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYK---GEKVTELIAFVVPKPGAEAgLTKAIKAELAERLPPYMIPRR 429

                          490       500
                   ....*....|....*....|
gi 1827387616 1511 AIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05945    430 FVYLDELPLNANGKIDRKAL 449

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

1050-1531

2.75e-95

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 318.26 E-value: 2.75e-95

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd17656      2 PDAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIM 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDASTRARLGESSCEWVDLADLEAEaESGDDItdterNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd17656     82 LDSGVRVVLTQRHLKSKLSFNKSTILLEDPSISQ-EDTSNI-----DYINNSDDLLYIIYTSGTTGKPKGVQLEHKNMVN 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQA---DFagDALATVLERDEVTDMIITPSV 1286
Cdd:cd17656    156 LLHFEREKTNINFSD----KVLQFATCSFDVCYQEIFSTLLSGGTLYIIREEtkrDV--EQLFDLVKRHNIEVVFLPVAF 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1287 LATVDPER------AQYVRNLATGGE--ACPPELVERWSERGRRIFNCYGPTEATVwATRSRMTAGKPVT----IGKPVD 1354
Cdd:cd17656    230 LKFIFSERefinrfPTCVKHIITAGEqlVITNEFKEMLHEHNVHLHNHYGPSETHV-VTTYTINPEAEIPelppIGKPIS 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1355 GFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRADHQ 1434
Cdd:cd17656    309 NTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPF-DPNERMYRTGDLARYLPDGNIEFLGRADHQ 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1435 VKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKpgATIDSAAVLDEAAQHLAAHMVPSQAIVI 1514
Cdd:cd17656    388 VKIRGYRIELGEIEAQLLNHPGVSEAVVLDKADDKGEK---YLCAYFVME--QELNISQLREYLAKQLPEYMIPSFFVPL 462

                          490
                   ....*....|....*..
gi 1827387616 1515 DEIPLTPAGKLDRAALP 1531
Cdd:cd17656    463 DQLPLTPNGKVDRKALP 479

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

2579-3059

3.28e-95

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 318.06 E-value: 3.28e-95

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd12114      1 PDATAVICGDG-TLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPITDAerlgevtaanLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd12114     80 LADAGARLVLTDGPDAQLDVAVFDVLILDLDALAAPAPPPPVDVAPDD----------LAYVIFTSGSTGTPKGVMISHR 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYrPSEAVGGEV--LERFIAEHGATHTFLTPSVL 2816
Cdd:cd12114    150 AALNTILDINRRFAVGPDDRVLALSSLSFDLSVYDIFGALSAGATLVL-PDEARRRDPahWAELIERHGVTLWNSVPALL 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2817 ------STMDPTAVPSLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGiTISSAMRPGDP----VRLGGPIG 2883
Cdd:cd12114    229 emlldvLEAAQALLPSLRLVLLSGDWIPLDLPARLralAPDARLISLGGATEASIW-SIYHPIDEVPPdwrsIPYGRPLA 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2884 GVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPygtAGQRMYRTGDVVRWTPDTdtgglTLEYTG 2963
Cdd:cd12114    308 NQRYRVLDPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHP---DGERLYRTGDLGRYRPDG-----TLEFLG 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2964 RSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEVS--ELKAFAGGRLPAYMVPSSFT 3041
Cdd:cd12114    380 RRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDPGGKRLAAFVVPDNDGTPIApdALRAFLAQTLPAYMIPSRVI 459

                          490
                   ....*....|....*...
gi 1827387616 3042 VIDELPLTPVGKLDKRAL 3059
Cdd:cd12114    460 ALEALPLTANGKVDRAAL 477

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

4-468

3.85e-95

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 316.50 E-value: 3.85e-95

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDge 83
Cdd:cd05945     20 RELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERIREILDAAKPALLIADGD-- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aearsrfddivdvhvldisspgdaDLdeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05945     98 ------------------------DN--------------AYIIFTSGSTGRPKGVQISHDNLVSFTNWMLSDFPLGPGD 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVP------AMLAAFNEvlgagvGEL 237
Cdd:cd05945    140 VFLNQAPFSFDLSVMDLYPALASGATLVPVPRDATADPKQLFRFLAEHGITVWVSTPsfaamcLLSPTFTP------ESL 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  238 TSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQD-----DRViPIGTPTRRVSARVLDAALRE 312
Cdd:cd05945    214 PSLRHFLFCGEVLPHKTARALQQRFPDARIYNTYGPTEATVAVTYIEVTPEvldgyDRL-PIGYAKPGAKLVILDEDGRP 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  313 VPIGVPGELYLGGVQLARGYAGRPDLTAERFvadpFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEV 392
Cdd:cd05945    293 VPPGEKGELVISGPSVSKGYLNNPEKTAAAF----FPDEGQRAYRTGDLVRLEADGLLFYRGRLDFQVKLNGYRIELEEI 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  393 EAALAAAPGVlHAAAAVV--DGPGGQQLVGYLAP----ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRR 466
Cdd:cd05945    369 EAALRQVPGV-KEAVVVPkyKGEKVTELIAFVVPkpgaEAGLTKAIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRK 447


                   ..
gi 1827387616  467 LL 468
Cdd:cd05945    448 AL 449

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

1-469

1.16e-94

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 315.49 E-value: 1.16e-94

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVG-AEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvt 79
Cdd:cd17648     13 LTYRELNERANRLAHYLLSVAEIrPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFILEDTGARVVI-- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   80 sdgeaearsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDL 159
Cdd:cd17648     91 --------------------------------------TNSTDLAYAIYTSGTTGKPKGVLVEHGSVVNLRTSLSERYFG 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARD--VFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNevlgagVGEL 237
Cdd:cd17648    133 RDNGdeAVLFFSNYVFDFFVEQMTLALLNGQKLVVPPDEMRFDPDRFYAYINREKVTYLSGTPSVLQQYD------LARL 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  238 TSLRLIQTGGEALTPPVARDLMVRLPGtRLQNQYGPAEASIVVTIHRVTQDDRV-IPIGTPTRRVSARVLDAALREVPIG 316
Cdd:cd17648    207 PHLKRVDAAGEEFTAPVFEKLRSRFAG-LIINAYGPTETTVTNHKRFFPGDQRFdKSLGRPVRNTKCYVLNDAMKRVPVG 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  317 VPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPG-------ARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLEL 389
Cdd:cd17648    286 AVGELYLGGDGVARGYLNRPELTAERFLPNPFQTEQerargrnARLYKTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEP 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  390 GEVEAALAAAPGVLHAA------AAVVDGPGGQQLVGY--LAPADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSG 461
Cdd:cd17648    366 GEVEAALASYPGVRECAvvakedASQAQSRIQKYLVGYylPEPGHVPESDLLSFLRAKLPRYMVPARLVRLEGIPVTING 445


                   ....*...
gi 1827387616  462 KVDRRLLP 469
Cdd:cd17648    446 KLDVRALP 453

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

5-469

6.03e-94

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 314.41 E-value: 6.03e-94

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVtsdgEA 84
Cdd:cd17656     18 ELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIMLDSGVRVVLT----QR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   85 EARSRFDDIVDVHVLDisSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDV 164
Cdd:cd17656     94 HLKSKLSFNKSTILLE--DPSISQEDTSNIDYINNSDDLLYIIYTSGTTGKPKGVQLEHKNMVNLLHFEREKTNINFSDK 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  165 FLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQ 244
Cdd:cd17656    172 VLQFATCSFDVCYQEIFSTLLSGGTLYIIREETKRDVEQLFDLVKRHNIEVVFLPVAFLKFIFSEREFINRFPTCVKHII 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  245 TGGEAL--TPPVARDLMVRlpGTRLQNQYGPAEASiVVTIHRVTQDDRVI---PIGTPTRRVSARVLDAALREVPIGVPG 319
Cdd:cd17656    252 TAGEQLviTNEFKEMLHEH--NVHLHNHYGPSETH-VVTTYTINPEAEIPelpPIGKPISNTWIYILDQEQQLQPQGIVG 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  320 ELYLGGVQLARGYAGRPDLTAERFVADPFgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA 399
Cdd:cd17656    329 ELYISGASVARGYLNRQELTAEKFFPDPF-DPNERMYRTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNH 407

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  400 PGVLHAAAAV-VDGPGGQQLVGYLAP-ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:cd17656    408 PGVSEAVVLDkADDKGEKYLCAYFVMeQELNISQLREYLAKQLPEYMIPSFFVPLDQLPLTPNGKVDRKALP 479

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

5-469

1.23e-90

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 303.32 E-value: 1.23e-90

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvtsdgea 84
Cdd:cd17645     28 QLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDPDYPGERIAYMLADSSAKILL------- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   85 earsrfddivdvhvldisspgdadldeeefagpTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDV 164
Cdd:cd17645    101 ---------------------------------TNPDDLAYVIYTSGSTGLPKGVMIEHHNLVNLCEWHRPYFGVTPADK 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  165 FLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTvIHFVPAMLA-AFNEVlgagvgELTSLRLI 243
Cdd:cd17645    148 SLVYASFSFDASAWEIFPHLTAGAALHVVPSERRLDLDALNDYFNQEGIT-ISFLPTGAAeQFMQL------DNQSLRVL 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  244 QTGGEALTPPVARdlmvrlpGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYL 323
Cdd:cd17645    221 LTGGDKLKKIERK-------GYKLVNNYGPTENTVVATSFEIDKPYANIPIGKPIDNTRVYILDEALQLQPIGVAGELCI 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  324 GGVQLARGYAGRPDLTAERFVADPFgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVL 403
Cdd:cd17645    294 AGEGLARGYLNRPELTAEKFIVHPF-VPGERMYRTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIE 372

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616  404 HAAA-AVVDGPGGQQLVGYL-APADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:cd17645    373 LAAVlAKEDADGRKYLVAYVtAPEEIPHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKALP 440

AMP-binding

AMP-binding enzyme;

1-383

1.33e-90

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 302.31 E-value: 1.33e-90

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:pfam00501   22 LTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRLPAEELAYILEDSGAKVLITDD 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVDVHVLDISSPGDADLDEEEFAG-------------PTRPANAAFTLFTSGSTGRPKAVVITHRGIA 147
Cdd:pfam00501  102 ALKLEELLEALGKLEVVKLVLVLDRDPVLKEEPLPEeakpadvppppppPPDPDDLAYIIYTSGTTGKPKGVMLTHRNLV 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  148 NRLAA----DIEQYDLTARDVFLYKAPITFDVSVR-EIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAM 222
Cdd:pfam00501  182 ANVLSikrvRPRGFGLGPDDRVLSTLPLFHDFGLSlGLLGPLLAGATVVLPPGFPALDPAALLELIERYKVTVLYGVPTL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  223 LAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTrLQNQYGPAEASIVVTIHRVTQDDRVIP--IGTPTRR 300
Cdd:pfam00501  262 LNMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRFRELFGGA-LVNGYGLTETTGVVTTPLPLDEDLRSLgsVGRPLPG 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  301 VSARVLDAA-LREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgaRLYRTGDRARWNRDGEIEYLGRTDFQ 379
Cdd:pfam00501  341 TEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDED-------GWYRTGDLGRRDEDGYLEIVGRKKDQ 413


                   ....
gi 1827387616  380 VKLR 383
Cdd:pfam00501  414 IKLG 417

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

1-477

2.19e-90

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 302.88 E-value: 2.19e-90

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVts 80
Cdd:COG0318     25 LTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLNPRLTAEELAYILEDSGARALVT-- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:COG0318    103 -------------------------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLT 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVRE-IFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTS 239
Cdd:COG0318    140 PGDVVLVALPLFHVFGLTVgLLAPLLAGATLVLL---PRFDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSS 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRV-TQDDRVIPIGTPTRRVSARVLDAALREVPIGVP 318
Cdd:COG0318    217 LRLVVSGGAPLPPELLERFEERF-GVRIVEGYGLTETSPVVTVNPEdPGERRPGSVGRPLPGVEVRIVDEDGRELPPGEV 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GELYLGGVQLARGYAGRPDLTAERFvADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAA 398
Cdd:COG0318    296 GEIVVRGPNVMKGYWNDPEATAEAF-RDGW-------LRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAA 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  399 APGVLHAAAAVVDGP-GGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEIA 474
Cdd:COG0318    368 HPGVAEAAVVGVPDEkWGERVVAFVVLrpgAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYAA 447


                   ...
gi 1827387616  475 PTL 477
Cdd:COG0318    448 GAL 450

AMP-binding

AMP-binding enzyme;

2571-2972

2.96e-90

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 301.15 E-value: 2.96e-90

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2571 FRAAARRAPDHVAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDY 2650
Cdd:pfam00501    1 LERQAARTPDKTALEVGEGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2651 PAERVASMIEDSGAVL----------GLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPITDAERLGEVTAANLAYV 2720
Cdd:pfam00501   81 PAEELAYILEDSGAKVlitddalkleELLEALGKLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDPDDLAYI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2721 IYTSGSTGRPKGVAVTHSGLANFARQ----ESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEG-TLAY-RPSEAVGG 2794
Cdd:pfam00501  161 IYTSGTTGKPKGVMLTHRNLVANVLSikrvRPRGFGLGPDDRVLSTLPLFHDFGLSLGLLGPLLAGaTVVLpPGFPALDP 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2795 EVLERFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTiGITI 2866
Cdd:pfam00501  241 AALLELIERYKVTVLYGVPTLLNMLleagapKRALLSSLRLVLSGGAPLPPELARRFRELFggALVNGYGLTETT-GVVT 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2867 SSAMRPGDPVRL---GGPIGGVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTAnpygtagQRMYRT 2942
Cdd:pfam00501  320 TPLPLDEDLRSLgsvGRPLPGTEVKIVDdETGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDE-------DGWYRT 392

                          410       420       430
                   ....*....|....*....|....*....|
gi 1827387616 2943 GDVVRWTPDTdtgglTLEYTGRSDDQVKLR 2972
Cdd:pfam00501  393 GDLGRRDEDG-----YLEIVGRKKDQIKLG 417

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

1045-1531

1.28e-88

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 297.54 E-value: 1.28e-88

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1045 QRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADR 1124
Cdd:cd17645      7 QVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDPDYPGER 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1125 IAYMLEDSGATVGITDAStrarlgesscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSH 1204
Cdd:cd17645     87 IAYMLADSSAKILLTNPD----------------------------------------DLAYVIYTSGSTGLPKGVMIEH 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1205 TGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQAdfagdalaTVLERDEVTDMI--- 1281
Cdd:cd17645    127 HNLVNLCEWHRPYFGVTPAD----KSLVYASFSFDASAWEIFPHLTAGAALHVVPSE--------RRLDLDALNDYFnqe 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1282 -ITPSVLATVDPER-----AQYVRNLATGGEAcppelVERWSERGRRIFNCYGPTEATVWATRSRMTagKP---VTIGKP 1352
Cdd:cd17645    195 gITISFLPTGAAEQfmqldNQSLRVLLTGGDK-----LKKIERKGYKLVNNYGPTENTVVATSFEID--KPyanIPIGKP 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1353 VDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRAD 1432
Cdd:cd17645    268 IDNTRVYILDEALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKFIVHPF-VPGERMYRTGDLAKFLPDGNIEFLGRLD 346

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1433 HQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVEStRGGRKHteVVAYLVAKpgATIDSAAVLDEAAQHLAAHMVPSQAI 1512
Cdd:cd17645    347 QQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKED-ADGRKY--LVAYVTAP--EEIPHEELREWLKNDLPDYMIPTYFV 421

                          490
                   ....*....|....*....
gi 1827387616 1513 VIDEIPLTPAGKLDRAALP 1531
Cdd:cd17645    422 HLKALPLTANGKVDRKALP 440

SgcC5_NRPS-like

cd19539

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

570-996

2.00e-87

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs; SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 293.52 E-value: 2.00e-87

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVY-PSVGAAPVQDVLPVAVAReq 648
Cdd:cd19539      1 RIPLSFAQERLWFIDQGEDGGPAYNIPGAWRLTGPLDVEALREALRDVVARHEALRTLLvRDDGGVPRQEILPPGPAP-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  649 LDWREADSVESLVRSTTE---------GFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARA 718
Cdd:cd19539     79 LEVRDLSDPDSDRERRLEellreresrGFDLDEEPPIRAVLGRFDPDDHVlVLVAHHTAFDAWSLDVFARDLAALYAARR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  719 EGRTGGLPVLDVQYADYALWQQSVLGDaddetSVLGEQLSHWRRVLAGLpAVTDLPMDRPRPAVLGTAGATVTVEFDDDL 798
Cdd:cd19539    159 KGPAAPLPELRQQYKEYAAWQREALAA-----PRAAELLDFWRRRLRGA-EPTALPTDRPRPAGFPYPGADLRFELDAEL 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  799 ADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNV 878
Cdd:cd19539    233 VAALRELAKRARSSLFMVLLAAYCVLLRRYTGQTDIVVGTPVAGRNHPRFESTVGFFVNLLPLRVDVSDCATFRDLIARV 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  879 RTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTepTVNDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRARS 958
Cdd:cd19539    313 RKALVDAQRHQELPFQQLVAELPVDRDAGRHPLVQIVFQVT--NAPAGELELAGGLSYTEGSDIPDGAKFDLNLTVTEEG 390

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1827387616  959 GGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19539    391 TG--LRGSLGYATSLFDEETIQGFLADYLQVLRQLLAN 426

Condensation

pfam00668

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

572-1010

3.69e-85

Condensation domain; This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 288.08 E-value: 3.69e-85

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  572 PLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYP-SVGAAPVQ---DVLPVAVARE 647
Cdd:pfam00668    6 PLSPAQKRMWFLEKLEPHSSAYNMPAVLKLTGELDPERLEKALQELINRHDALRTVFIrQENGEPVQvilEERPFELEII 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  648 QLDWREADSVESLV-----RSTTEGFDVSTQMPLR-GRFHRDGAGLHVALTMHHIAMDGQSIPVLARDLMSAYAARAEGR 721
Cdd:pfam00668   86 DISDLSESEEEEAIeafiqRDLQSPFDLEKGPLFRaGLFRIAENRHHLLLSMHHIIVDGVSLGILLRDLADLYQQLLKGE 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  722 TggLPVLDVQ-YADYALWQQSVLGDADDEtsvlgEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLAD 800
Cdd:pfam00668  166 P--LPLPPKTpYKDYAEWLQQYLQSEDYQ-----KDAAYWLEQLEGELPVLQLPKDYARPADRSFKGDRLSFTLDEDTEE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  801 RVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRT 880
Cdd:pfam00668  239 LLRKLAKAHGTTLNDVLLAAYGLLLSRYTGQDDIVVGTPGSGRPSPDIERMVGMFVNTLPLRIDPKGGKTFSELIKRVQE 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  881 TVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTY-------TEPTVNDVAGLEASgIQAAPVDTgvvnAKFDLTVA 953
Cdd:pfam00668  319 DLLSAEPHQGYPFGDLVNDLRLPRDLSRHPLFDPMFSFqnylgqdSQEEEFQLSELDLS-VSSVIEEE----AKYDLSLT 393

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616  954 VRARSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDIVGAA 1010
Cdd:pfam00668  394 ASERGGG--LTIKIDYNTSLFDEETIERFAEHFKELLEQAIAHPSQPLSELDLLSDA 448

AMP-binding

AMP-binding enzyme;

1050-1437

1.69e-84

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 284.59 E-value: 1.69e-84

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTE-MDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYM 1128
Cdd:pfam00501    9 PDKTALEVGEGRrLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRLPAEELAYI 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1129 LEDSGATVGITDASTRARLGE---------SSCEWVDLADLEAE----AESGDDITDTERNGSVRLTNLAYLIYTSGSTG 1195
Cdd:pfam00501   89 LEDSGAKVLITDDALKLEELLealgklevvKLVLVLDRDPVLKEeplpEEAKPADVPPPPPPPPDPDDLAYIIYTSGTTG 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1196 RPKAVGVSHTGIVDFVNSLAKITTGTPEDEPDTRILHVASPSFDASM-FEMAWAIPAGHTLVIAPQAD-FAGDALATVLE 1273
Cdd:pfam00501  169 KPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVLSTLPLFHDFGLsLGLLGPLLAGATVVLPPGFPaLDPAALLELIE 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1274 RDEVTDMIITPSVLATV----DPERAQY--VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKP 1346
Cdd:pfam00501  249 RYKVTVLYGVPTLLNMLleagAPKRALLssLRLVLSGGAPLPPELARRFRELfGGALVNGYGLTETTGVVTTPLPLDEDL 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1347 V---TIGKPVDGFTVRVLD-GRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgepgaRMYATGDLVRVAKG 1422
Cdd:pfam00501  329 RslgSVGRPLPGTEVKIVDdETGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDED-------GWYRTGDLGRRDED 401

                          410
                   ....*....|....*
gi 1827387616 1423 GNLEFAGRADHQVKI 1437
Cdd:pfam00501  402 GYLEIVGRKKDQIKL 416

PRK04813

D-alanine--poly(phosphoribitol) ligase subunit DltA;

2575-3063

3.11e-75

D-alanine--poly(phosphoribitol) ligase subunit DltA;

Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 260.98 E-value: 3.11e-75

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAER 2654
Cdd:PRK04813    12 AQTQPDFPAY-DYLGEKLTYGQLKEDSDALAAFIDSLKLPDKSPIIVFGHMSPEMLATFLGAVKAGHAYIPVDVSSPAER 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2655 VASMIEDSGAVLglsVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPITDAerlgeVTAANLAYVIYTSGSTGRPKGVA 2734
Cdd:PRK04813    91 IEMIIEVAKPSL---IIATEELPLEILGIPVITLDELKDIFATGNPYDFDHA-----VKGDDNYYIIFTSGTTGKPKGVQ 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2735 VTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVG--GEVLERFIAEHGATHTFlT 2812
Cdd:PRK04813   163 ISHDNLVSFTNWMLEDFALPEGPQFLNQAPYSFDLSVMDLYPTLASGGTLVALPKDMTAnfKQLFETLPQLPINVWVS-T 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2813 PSV--LSTMDPT----AVPSLRVIAAGGEAVP----QPIVDRWaPATELHNLYGPTETTIGIT---ISSAMRPGDPvRLg 2879
Cdd:PRK04813   242 PSFadMCLLDPSfneeHLPNLTHFLFCGEELPhktaKKLLERF-PSATIYNTYGPTEATVAVTsieITDEMLDQYK-RL- 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2880 gPIG----GVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtAGQRMYRTGDVVRWTpdtdtG 2955
Cdd:PRK04813   319 -PIGyakpDSPLLIIDEEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEAFFTF----DGQPAYHTGDAGYLE-----D 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2956 GLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV--GGSVaTALAAYIVPVDGAVE-----VSELKAFAG 3028
Cdd:PRK04813   389 GL-LFYQGRIDFQIKLNGYRIELEEIEQNLRQSSYVESAVVVPYnkDHKV-QYLIAYVVPKEEDFErefelTKAIKKELK 466

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1827387616 3029 GRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPV 3063
Cdd:PRK04813   467 ERLMEYMIPRKFIYRDSLPLTPNGKIDRKALIEEV 501

E_NRPS

cd19534

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

1633-2069

7.14e-74

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the Condensation-domain family; Epimerization (E) domains of nonribosomal peptide synthetases (NRPS) flip the chirality of the end amino acid of a peptide being manufactured by the NRPS. E-domains are homologous to the Condensation (C) domains. NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Specialized tailoring NRPS domains such as E-domains greatly increase the range of possible peptide products created by the NRPS machinery. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the E-domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 254.48 E-value: 7.14e-74

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1633 EMPLPPVTSWMIEHSeePADFADFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTM---NAGAGIVPA 1709
Cdd:cd19534      1 EVPLTPIQRWFFEQN--LAGRHHFNQSVLLRVPQGLDPDALRQALRALVEHHDALRMRFRREDGGWQQrirGDVEELFRL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1710 ----VREIDAEGALDPALVDAHRellgAMDPGTGSLLGTAVVNGEGR-RRLVIAIHHLGVDAVSWPILVEDLVTAWAQLT 1784
Cdd:cd19534     79 evvdLSSLAQAAAIEALAAEAQS----SLDLEEGPLLAAALFDGTDGgDRLLLVIHHLVVDGVSWRILLEDLEAAYEQAL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1785 SGRPIELrPEATTTRRIAHLLA--GQVHARAREVDYWLEQLPerPTSFGTSADRPlHRRRDESSLTYVVD-DVAGSILTT 1861
Cdd:cd19534    155 AGEPIPL-PSKTSFQTWAELLAeyAQSPALLEELAYWRELPA--ADYWGLPKDPE-QTYGDARTVSFTLDeEETEALLQE 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1862 VPQAFGSSVDDVLLGALARAVRAWqldngiADGGPVTVSTEGHGRDESIAGdegaIDLSRTVGWFTSITP--LAVDASSD 1939
Cdd:cd19534    231 ANAAYRTEINDLLLAALALAFQDW------TGRAPPAIFLEGHGREEIDPG----LDLSRTVGWFTSMYPvvLDLEASED 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1940 VVHAVKSAKDARLSRPAGGVGFGILRY-NSDGE--IAHRPLPTIMYNYFGGGTAPSTetapDDFLPVSDRPNMPSSITGA 2016
Cdd:cd19534    301 LGDTLKRVKEQLRRIPNKGIGYGILRYlTPEGTkrLAFHPQPEISFNYLGQFDQGER----DDALFVSAVGGGGSDIGPD 376

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 2017 MRSPSVFGINISTAGreeRRLEAKVTYATDALDEAAASDIARRWHDELRAVVE 2069
Cdd:cd19534    377 TPRFALLDINAVVEG---GQLVITVSYSRNMYHEETIQQLADSYKEALEALIE 426

X-Domain_NRPS

cd19546

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to ...

567-996

1.91e-72

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to the non-ribosomal peptide synthetase (NRPS); The X-domain is a catalytically inactive member of the Condensation (C) domain family of non-ribosomal peptide synthetase (NRPS). It has been shown to recruit oxygenases to the NRPS to perform side-chain crosslinking in the production of glycopeptide antibiotics. C-domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as this X-domain, the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, and dual E/C (epimerization and condensation) domains. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity; members of this X-domain subfamily lack the second H of this motif.

Pssm-ID: 380468 [Multi-domain] Cd Length: 440 Bit Score: 250.86 E-value: 1.91e-72

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  567 RPERLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVAVAR 646
Cdd:cd19546      1 RPDEVPATAGQLRTWLLARLDEETRGRHLSVALRLRGRLDRDALEAALGDVAARHEILRTTFPGDGGDVHQRILDADAAR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  647 EQLDWREADSVE---SLVRSTTEGFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARAEGRT 722
Cdd:cd19546     81 PELPVVPATEEElpaLLADRAAHLFDLTRETPWRCTLFALSDTEHVlLLVVHRIAADDESLDVLVRDLAAAYGARREGRA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  723 GGLPVLDVQYADYALWQQSVLGDADDETSVLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRV 802
Cdd:cd19546    161 PERAPLPLQFADYALWERELLAGEDDRDSLIGDQIAYWRDALAGAPDELELPTDRPRPVLPSRRAGAVPLRLDAEVHARL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  803 DVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDP-ALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTT 881
Cdd:cd19546    241 MEAAESAGATMFTVVQAALAMLLTRLGAGTDVTVGTVLPRDDEEgDLEGMVGPFARPLALRTDLSGDPTFRELLGRVREA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  882 VLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEPTVNDVAGLEASGIQAAPVDTGVVNAKFDLTVAV--RARSG 959
Cdd:cd19546    321 VREARRHQDVPFERLAELLALPPSADRHPVFQVALDVRDDDNDPWDAPELPGLRTSPVPLGTEAMELDLSLALteRRNDD 400

                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 1827387616  960 GTP--MAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19546    401 GDPdgLDGSLRYAADLFDRATAAALARRLVRVLEQVAAD 439

Condensation

pfam00668

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

2104-2554

1.04e-70

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 246.09 E-value: 1.04e-70

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2104 ADVWPMTPLQQG-LFFQADLANTVAdhdaidvYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVV 2182
Cdd:pfam00668    2 QDEYPLSPAQKRmWFLEKLEPHSSA-------YNMPAVLKLTGELDPERLEKALQELINRHDALRTVFIRQENGEPVQVI 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2183 PAEVTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGD-GAELVVTNHHLLIDGWSSPLVLADL 2261
Cdd:pfam00668   75 LEERPFELEIIDISDLSESEEEEAIEAFIQRDLQSPFDLEKGPLFRAGLFRIAEnRHHLLLSMHHIIVDGVSLGILLRDL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2262 LSLYAT---GQTfTGSLPGTSGRDFADHARAVAT-ADVEAGIAAWREVLAPVTEPTLVAPGHEPSADAPPRDHQFSIDV- 2336
Cdd:pfam00668  155 ADLYQQllkGEP-LPLPPKTPYKDYAEWLQQYLQsEDYQKDAAYWLEQLEGELPVLQLPKDYARPADRSFKGDRLSFTLd 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2337 -KVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGR-SPDIegmESMVGMFINTIPAVVDVNPDATVV 2414
Cdd:pfam00668  234 eDTEELLRKLAKAHGTTLNDVLLAAYGLLLSRYTGQDDIVVGTPGSGRpSPDI---ERMVGMFVNTLPLRIDPKGGKTFS 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2415 DVLTAVQNDKVKVLDHQQIGLPRLVAQTGLP------ALFDTLAVYESFPVNvDSVAGIDASSAGGLKlVGAKTSDATHY 2488
Cdd:pfam00668  311 ELIKRVQEDLLSAEPHQGYPFGDLVNDLRLPrdlsrhPLFDPMFSFQNYLGQ-DSQEEEFQLSELDLS-VSSVIEEEAKY 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2489 PLNLSASRRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLLPAEAAVELT 2554
Cdd:pfam00668  389 DLSLTASERGGGLTIKIDYNTSLFDEETIERFAEHFKELLEQAIAHPSQPLSELDLLSDAEKQKLL 454

AFD_class_I

cd04433

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...

1184-1526

3.41e-69

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.

Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 237.57 E-value: 3.41e-69

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1184 LAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPqaDF 1263
Cdd:cd04433      2 PALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGD----VFLSTLPLFHIGGLFGLLGALLAGGTVVLLP--KF 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1264 AGDALATVLERDEVTDMIITPSVLATVD--PERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWA 1336
Cdd:cd04433     76 DPEAALELIEREKVTILLGVPTLLARLLkaPESAGYdlssLRALVSGGAPLPPELLERFEEApGIKLVNGYGLTETGGTV 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1337 T--RSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFvadpfgEPGarMYATG 1414
Cdd:cd04433    156 AtgPPDDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVD------EDG--WYRTG 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAV 1494
Cdd:cd04433    228 DLGRLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGE---RVVAVVVLRPGADLDAEEL 304

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1827387616 1495 LDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:cd04433    305 RAHVRERLAPYKVPRRVVFVDALPRTASGKID 336

C_NRPS-like

cd19066

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

571-996

3.73e-66

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long, with various activities such as antibiotic, antifungal, antitumor and immunosuppression. There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 231.91 E-value: 3.73e-66

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  571 LPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVAVARE--- 647
Cdd:cd19066      2 IPLSPMQRGMWFLKKLATDPSAFNVAIEMFLTGSLDLARLKQALDAVMERHDVLRTRFCEEAGRYEQVVLDKTVRFRiei 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  648 ----QLDWREADSVESLVRSTTEGFDVSTQMPLRGR-FHRDGAGLHVALTMHHIAMDGQSIPVLARDLMSAYAArAEGRT 722
Cdd:cd19066     82 idlrNLADPEARLLELIDQIQQTIYDLERGPLVRVAlFRLADERDVLVVAIHHIIVDGGSFQILFEDISSVYDA-AERQK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  723 GGLPVLDVQYADYALWQQSVLGDADdetsvLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRV 802
Cdd:cd19066    161 PTLPPPVGSYADYAAWLEKQLESEA-----AQADLAYWTSYLHGLPPPLPLPKAKRPSQVASYEVLTLEFFLRSEETKRL 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  803 DVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTTV 882
Cdd:cd19066    236 REVARESGTTPTQLLLAAFALALKRLTASIDVVIGLTFLNRPDEAVEDTIGLFLNLLPLRIDTSPDATFPELLKRTKEQS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  883 LDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTepTVNDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRARSGGTP 962
Cdd:cd19066    316 REAIEHQRVPFIELVRHLGVVPEAPKHPLFEPVFTFK--NNQQQLGKTGGFIFTTPVYTSSEGTVFDLDLEASEDPDGDL 393

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1827387616  963 MAAdFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19066    394 LLR-LEYSRGVYDERTIDRFAERYMTALRQLIEN 426

CT_NRPS-like

cd19542

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

2106-2535

1.86e-64

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike bacterial NRPS, which typically have specialized terminal thioesterase (TE) domains to cyclize peptide products, many fungal NRPSs employ a terminal condensation-like (CT) domain to produce macrocyclic peptidyl products (e.g. cyclosporine and echinocandin). Domains in this subfamily (which includes both terminal and non-terminal domains) typically have a non-canonical conserved [SN]HxxxDx(14)Y motif at their active site compared to the standard Condensation (C) domain active site motif (HHxxxD). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 226.03 E-value: 1.86e-64

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2106 VWPMTPLQQGLffqadLANTVADHDaidVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPS-GAAVTVVPA 2184
Cdd:cd19542      1 IYPCTPMQEGM-----LLSQLRSPG---LYFNHFVFDLDSSVDVERLRNAWRQLVQRHDILRTVFVESSAeGTFLQVVLK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2185 EVTVPWSVIdlraedaasldSRVEEVLATERTNPFDM---AKPPLIRVVLVEHGDG-AELVVTNHHLLIDGWSSPLVLAD 2260
Cdd:cd19542     73 SLDPPIEEV-----------ETDEDSLDALTRDLLDDptlFGQPPHRLTLLETSSGeVYLVLRISHALYDGVSLPIILRD 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2261 LLSLYaTGQTftgSLPGTSgrdFADHARAVATADVEAGIAAWREVLA---PVTEPTLVapghePSADAPPRDHQFSIDvk 2337
Cdd:cd19542    142 LAAAY-NGQL---LPPAPP---FSDYISYLQSQSQEESLQYWRKYLQgasPCAFPSLS-----PKRPAERSLSSTRRS-- 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2338 vTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVL 2417
Cdd:cd19542    208 -LAKLEAFCASLGVTLASLFQAAWALVLARYTGSRDVVFGYVVSGRDLPVPGIDDIVGPCINTLPVRVKLDPDWTVLDLL 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2418 TAVQNDKVKVLDHQQIGLPRLVAQTGLPA---LFDTLAVYESFPVNVDSvagidaSSAGGLKLVGAKTSDATHYPLNLSA 2494
Cdd:cd19542    287 RQLQQQYLRSLPHQHLSLREIQRALGLWPsgtLFNTLVSYQNFEASPES------ELSGSSVFELSAAEDPTEYPVAVEV 360

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1827387616 2495 SRRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19542    361 EPSGDSLKVSLAYSTSVLSEEQAEELLEQFDDILEALLANP 401

AFD_class_I

cd04433

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...

124-464

5.20e-63

Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 219.46 E-value: 5.20e-63

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  124 AFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPgrhGDPVH 203
Cdd:cd04433      3 ALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHIGGLFGLLGALLAGGTVVLLPK---FDPEA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  204 LADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEASIVVTIH 283
Cdd:cd04433     80 ALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFE-EAPGIKLVNGYGLTETGGTVATG 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIP-IGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFvadpfgEPGarLYRTGDRA 362
Cdd:cd04433    159 PPDDDARKPGsVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVD------EDG--WYRTGDLG 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  363 RWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAP---ADVDVDTVAATTAE 438
Cdd:cd04433    231 RLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVvGVPDPEWGERVVAVVVLrpgADLDAEELRAHVRE 310

                          330       340
                   ....*....|....*....|....*.
gi 1827387616  439 LLPEYMRPSAWVRLDAMPLSRSGKVD 464
Cdd:cd04433    311 RLAPYKVPRRVVFVDALPRTASGKID 336

alpha_am_amid

TIGR03443

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...

2482-3144

1.42e-62

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.

Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 238.04 E-value: 1.42e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2482 TSDATHYPLNLSASrrGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHPEATCAEIPLL-PAEAAVELTPVTG-- 2558
Cdd:TIGR03443  153 TGSTTDLTVFLTPS--SPELELSIYYNSLLFSSDRITIVADQLAQLLSAASSNPDEPIGKVSLItPSQKSLLPDPTKDld 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2559 -----GPATDpvtlaeLFRAAARRAPDHVAVVDGAGAR--------LTYRELDEASDRLARWLIGRGVGPERAVALAIGR 2625
Cdd:TIGR03443  231 wsgfrGAIHD------IFADNAEKHPDRTCVVETPSFLdpssktrsFTYKQINEASNILAHYLLKTGIKRGDVVMIYAYR 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2626 SAQLLTAIWAVAKTGGAYVPIDPDYPAER------VAS-----MIEDSGA------------------VLGLSVLASGDL 2676
Cdd:TIGR03443  305 GVDLVVAVMGVLKAGATFSVIDPAYPPARqtiylsVAKpraliVIEKAGTldqlvrdyidkelelrteIPALALQDDGSL 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2677 PGQEFEWMRLDDDSVAAEIAAVPAGPItdaerLGEVTAANLAYviyTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDN 2756
Cdd:TIGR03443  385 VGGSLEGGETDVLAPYQALKDTPTGVV-----VGPDSNPTLSF---TSGSEGIPKGVLGRHFSLAYYFPWMAKRFGLSEN 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2757 ------------PVVLGFASPSFDASVLeyLLATV----NEGTLAyrpseavggevleRFIAEHGATHTFLTPS---VLS 2817
Cdd:TIGR03443  457 dkftmlsgiahdPIQRDMFTPLFLGAQL--LVPTAddigTPGRLA-------------EWMAKYGATVTHLTPAmgqLLS 521

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2818 TMDPTAVPSLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGI---TISSamRPGDPVRLGG-----PIG--- 2883
Cdd:TIGR03443  522 AQATTPIPSLHHAFFVGDILTKRDCLRLqtlAENVCIVNMYGTTETQRAVsyfEIPS--RSSDSTFLKNlkdvmPAGkgm 599

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2884 -GVDLMVLD--ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQ---------------------RM 2939
Cdd:TIGR03443  600 kNVQLLVVNrnDRTQTCGVGEVGEIYVRAGGLAEGYLGLPELNAEKFVNNWFVDPSHwidldkennkperefwlgprdRL 679

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2940 YRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLgV--GGSVATALAAYIVPVDGA 3017
Cdd:TIGR03443  680 YRTGDLGRYLPDGN-----VECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTL-VrrDKDEEPTLVSYIVPQDKS 753

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3018 VEVSELKA---------------------------FAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGEYV 3070
Cdd:TIGR03443  754 DELEEFKSevddeessdpvvkglikyrklikdireYLKKKLPSYAIPTVIVPLKKLPLNPNGKVDKPALPFPDTAQLAAV 833

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3071 AP----------ATGTERTIADVAAGVLNIDAGLVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRAL 3140
Cdd:TIGR03443  834 AKnrsasaadeeFTETEREIRDLWLELLPNRPATISPDDSFFDLGGHSILATRMIFELRKKLNVELPLGLIFKSPTIKGF 913


                   ....
gi 1827387616 3141 AETV 3144
Cdd:TIGR03443  914 AKEV 917

PRK04813

D-alanine--poly(phosphoribitol) ligase subunit DltA;

1040-1530

6.96e-62

D-alanine--poly(phosphoribitol) ligase subunit DltA;

Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 222.08 E-value: 6.96e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1040 IDVLAQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAV--GME-RSIGSVLatwGVIKSGAAYVPV 1116
Cdd:PRK04813     8 IEEFAQTQ--PDFPAYDYLGEKLTYGQLKEDSDALAAFIDSLKLPDKSPIIVfgHMSpEMLATFL---GAVKAGHAYIPV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1117 DPAYPADRIAYMLEDSGATVGITDASTRarLGESSCEWVDLADLEAEAESGddiTDTERNGSVRLTNLAYLIYTSGSTGR 1196
Cdd:PRK04813    83 DVSSPAERIEMIIEVAKPSLIIATEELP--LEILGIPVITLDELKDIFATG---NPYDFDHAVKGDDNYYIIFTSGTTGK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1197 PKAVGVSHTGIVDFVNSLAKITtGTPEDEpdtRILHVASPSFDASMfeMAWAiPA---GHTLVIAPQ---ADFAgdALAT 1270
Cdd:PRK04813   158 PKGVQISHDNLVSFTNWMLEDF-ALPEGP---QFLNQAPYSFDLSV--MDLY-PTlasGGTLVALPKdmtANFK--QLFE 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1271 VLERDEVTDMIITPSV--LATVDPE-RAQYVRNLAT---GGEACP----PELVERWSERgrRIFNCYGPTEATVWATRSR 1340
Cdd:PRK04813   229 TLPQLPINVWVSTPSFadMCLLDPSfNEEHLPNLTHflfCGEELPhktaKKLLERFPSA--TIYNTYGPTEATVAVTSIE 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1341 MT-----AGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFvadpFGEPGARMYATGD 1415
Cdd:PRK04813   307 ITdemldQYKRLPIGYAKPDSPLLIIDEEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEAF----FTFDGQPAYHTGD 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1416 LVrVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVEStrgGRKHTEVVAYLVAKPG-----ATId 1490
Cdd:PRK04813   383 AG-YLEDGLLFYQGRIDFQIKLNGYRIELEEIEQNLRQSSYVESAVVVPYNK---DHKVQYLIAYVVPKEEdfereFEL- 457

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1827387616 1491 SAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK04813   458 TKAIKKELKERLMEYMIPRKFIYRDSLPLTPNGKIDRKAL 497

AFD_class_I

cd04433

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...

2717-3055

1.18e-61

Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 215.61 E-value: 1.18e-61

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2717 LAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEaVGGEV 2796
Cdd:cd04433      2 PALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHIGGLFGLLGALLAGGTVVLLPKF-DPEAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2797 LERfIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRW--APATELHNLYGPTETTIGITIss 2868
Cdd:cd04433     81 LEL-IEREKVTILLGVPTLLARLlkapesAGYDLSSLRALVSGGAPLPPELLERFeeAPGIKLVNGYGLTETGGTVAT-- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2869 aMRPGDPVRLGGPIG----GVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFtanpygtaGQRMYRTGD 2944
Cdd:cd04433    158 -GPPDDDARKPGSVGrpvpGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVD--------EDGWYRTGD 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2945 VVRWTPDtdtGGLTleYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVAT-ALAAYIVPVDGA-VEVSE 3022
Cdd:cd04433    229 LGRLDED---GYLY--IVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGeRVVAVVVLRPGAdLDAEE 303

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1827387616 3023 LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLD 3055
Cdd:cd04433    304 LRAHVRERLAPYKVPRRVVFVDALPRTASGKID 336

FC-FACS_FadD_like

cd05936

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...

1050-1530

3.35e-61

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 218.97 E-value: 3.35e-61

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd05936     13 PDKTALIFMGRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLNPLYTPRELEHIL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDastrarlgesscewVDLADLEAEAESgdditdTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVd 1209
Cdd:cd05936     93 NDSGAKALIVA--------------VSFTDLLAAGAP------LGERVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLV- 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 fVNSLAKITTGTPEDEPDTRILhVASPSFD--ASMFEMAWAIPAGHTLVIAPQADFAGdALATvLERDEVTDMIITPSVL 1287
Cdd:cd05936    152 -ANALQIKAWLEDLLEGDDVVL-AALPLFHvfGLTVALLLPLALGATIVLIPRFRPIG-VLKE-IRKHRVTIFPGVPTMY 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1288 ATV--DPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAG-KPVTIGKPVDGFTVR 1359
Cdd:cd05936    228 IALlnAPEFKKRdfssLRLCISGGAPLPVEVAERFEELtGVPIVEGYGLTETSPVVAVNPLDGPrKPGSIGIPLPGTEVK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1360 VLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAGRADHQVKING 1439
Cdd:cd05936    308 IVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEETAEAFVDGWL--------RTGDIGYMDEDGYFFIVDRKKDMIIVGG 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1440 QRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPL 1519
Cdd:cd05936    380 FNVYPREVEEVLYEHPAVAEAAVVGVPDPYSG---EAVKAFVVLKEGASLTEEEIIAFCREQLAGYKVPRQVEFRDELPK 456

                          490
                   ....*....|.
gi 1827387616 1520 TPAGKLDRAAL 1530
Cdd:cd05936    457 SAVGKILRREL 467

FUM14_C_NRPS-like

cd19545

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond ...

2106-2535

3.63e-61

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond forming Fusarium verticillioides FUM14 protein; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) typically catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. However, some C-domains have ester-bond forming activity. This subfamily includes Fusarium verticillioides FUM14 (also known as NRPS8), a bi-domain protein with an ester-bond forming NRPS C-domain, which catalyzes linkages between an aminoacyl/peptidyl-PCP donor and a hydroxyl-containing acceptor. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. FUM14 has an altered active site motif DHTHCD instead of the typical HHxxxD motif seen in other subfamily members. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380467 [Multi-domain] Cd Length: 395 Bit Score: 216.40 E-value: 3.63e-61

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2106 VWPMTPLQQGLFfqadlANTVADHDAidvYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAE 2185
Cdd:cd19545      1 IYPCTPLQEGLM-----ALTARQPGA---YVGQRVFELPPDIDLARLQAAWEQVVQANPILRTRIVQSDSGGLLQVVVKE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2186 VTVPWsvidlraEDAASLDsrveEVLATERTNPFDmAKPPLIRVVLVEHGDGA-ELVVTNHHLLIDGWSSPLVLADLLSL 2264
Cdd:cd19545     73 SPISW-------TESTSLD----EYLEEDRAAPMG-LGGPLVRLALVEDPDTErYFVWTIHHALYDGWSLPLILRQVLAA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2265 YATGqtftgslPGTSGRDFADHARAVATADVEAGIAAWREVLAPVTE---PTLVAPGHEPSADAPpRDHQFSIDVKVTER 2341
Cdd:cd19545    141 YQGE-------PVPQPPPFSRFVKYLRQLDDEAAAEFWRSYLAGLDPavfPPLPSSRYQPRPDAT-LEHSISLPSSASSG 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2342 lealarnnsTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQ 2421
Cdd:cd19545    213 ---------VTLATVLRAAWALVLSRYTGSDDVVFGVTLSGRNAPVPGIEQIVGPTIATVPLRVRIDPEQSVEDFLQTVQ 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2422 NDKVKVLDHQQIGLP---RLVAQTGLPALFDTLAVyesfpVNVDSVAGIDASSAGGLKLVGAKTSDATHYPLNLSASRRG 2498
Cdd:cd19545    284 KDLLDMIPFEHTGLQnirRLGPDARAACNFQTLLV-----VQPALPSSTSESLELGIEEESEDLEDFSSYGLTLECQLSG 358

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1827387616 2499 AELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19545    359 SGLRVRARYDSSVISEEQVERLLDQFEHVLQQLASAP 395

C_PKS-NRPS

cd19532

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

572-997

4.32e-60

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHxxxD motif, a few such as Monascus pilosus lovastatin nonaketide synthase MokA have a non-canonical HRxxxD motif in the C-domain and are unable to catalyze amide-bond formation. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380455 [Multi-domain] Cd Length: 421 Bit Score: 214.24 E-value: 4.32e-60

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  572 PLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVY--PSVGAAPVQDVLP-------- 641
Cdd:cd19532      3 PMSFGQSRFWFLQQYLEDPTTFNVTFSYRLTGPLDVARLERAVRAVGQRHEALRTCFftDPEDGEPMQGVLAssplrleh 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  642 VAVAREQLDWREADSVESLVrsttegFDVSTQMPLRGRFHRDGAGLH-VALTMHHIAMDGQSIPVLARDLMSAYAARAeg 720
Cdd:cd19532     83 VQISDEAEVEEEFERLKNHV------YDLESGETMRIVLLSLSPTEHyLIFGYHHIAMDGVSFQIFLRDLERAYNGQP-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  721 rtggLPVLDVQYADYALWQQsvlgdADDETSVLGEQLSHWRRVLAGLPAVTDL-PMDR--PRPAVLGTAGATVTVEFDDD 797
Cdd:cd19532    155 ----LLPPPLQYLDFAARQR-----QDYESGALDEDLAYWKSEFSTLPEPLPLlPFAKvkSRPPLTRYDTHTAERRLDAA 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  798 LADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGN 877
Cdd:cd19532    226 LAARIKEASRKLRVTPFHFYLAALQVLLARLLDVDDICIGIADANRTDEDFMETIGFFLNLLPLRFRRDPSQTFADVLKE 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  878 VRTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEPTVNDV--AGLEASGIQAAPVDTGvvnakFDLTVAVR 955
Cdd:cd19532    306 TRDKAYAALAHSRVPFDVLLDELGVPRSATHSPLFQVFINYRQGVAESRpfGDCELEGEEFEDARTP-----YDLSLDII 380

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 1827387616  956 ARSGGTPMaADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQ 997
Cdd:cd19532    381 DNPDGDCL-LTLKVQSSLYSEEDAELLLDSYVNLLEAFARDP 421

FACL_FadD13-like

cd17631

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...

1048-1527

1.22e-59

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.

Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 213.24 E-value: 1.22e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1048 LDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:cd17631      7 RHPDRTALVFGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRLTPPEVAY 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDastrarlgesscewvdladleaeaesgdditdterngsvrltnLAYLIYTSGSTGRPKAVGVSHTGI 1207
Cdd:cd17631     87 ILADSGAKVLFDD-------------------------------------------LALLMYTSGTTGRPKGAMLTHRNL 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1208 vdFVNSLAKITTGTPEdePDTRILHVAsPSFDASMFEMaWAIP---AGHTLVIAPQADfAGDALATVlERDEVTDMIITP 1284
Cdd:cd17631    124 --LWNAVNALAALDLG--PDDVLLVVA-PLFHIGGLGV-FTLPtllRGGTVVILRKFD-PETVLDLI-ERHRVTSFFLVP 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1285 SVLATV--DPERAQY----VRNLATGGEACPPELVERWSERGRRIFNCYGPTEATVWAT--RSRMTAGKPVTIGKPVDGF 1356
Cdd:cd17631    196 TMIQALlqHPRFATTdlssLRAVIYGGAPMPERLLRALQARGVKFVQGYGMTETSPGVTflSPEDHRRKLGSAGRPVFFV 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1357 TVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAGRADHQVK 1436
Cdd:cd17631    276 EVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEATAAAFRDGWF--------HTGDLGRLDEDGYLYIVDRKKDMII 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1437 INGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDE 1516
Cdd:cd17631    348 SGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEA---VVAVVVPRPGAELDEDELIAHCRERLARYKIPKSVEFVDA 424

                          490
                   ....*....|.
gi 1827387616 1517 IPLTPAGKLDR 1527
Cdd:cd17631    425 LPRNATGKILK 435

Firefly_Luc_like

cd05911

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...

1054-1525

1.28e-59

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.

Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 214.77 E-value: 1.28e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1054 ALICD--GTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLED 1131
Cdd:cd05911      1 AQIDAdtGKELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1132 SGATVGITDASTRARLGESSCEWVD------LADLEAEAESGDDITDTERNGSVRL---------TNLAYLIYTSGSTGR 1196
Cdd:cd05911     81 SKPKVIFTDPDGLEKVKEAAKELGPkdkiivLDDKPDGVLSIEDLLSPTLGEEDEDlppplkdgkDDTAAILYSSGTTGL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1197 PKAVGVSHTGIVdfVNSLAKITTGTPEDEPDTRILHVaSPSFDAS-MFEMAWAIPAGHTLVIAPQADFAgDALATVlERD 1275
Cdd:cd05911    161 PKGVCLSHRNLI--ANLSQVQTFLYGNDGSNDVILGF-LPLYHIYgLFTTLASLLNGATVIIMPKFDSE-LFLDLI-EKY 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1276 EVTDMIITPSVLA------TVDPERAQYVRNLATGGEACPPELVERWSERGR--RIFNCYGPTEATVWATRSRMTAGKPV 1347
Cdd:cd05911    236 KITFLYLVPPIAAalakspLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPnaTIKQGYGMTETGGILTVNPDGDDKPG 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1348 TIGKPVDGFTVRVLD--GRLhEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNL 1425
Cdd:cd05911    316 SVGRLLPNVEAKIVDddGKD-SLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGW-------LHTGDIGYFDEDGYL 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1426 EFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEAAQHLAA 1504
Cdd:cd05911    388 YIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSG----ELpRAYVVRKPGEKLTEKEVKDYVAKKVAS 463

                          490       500
                   ....*....|....*....|....*
gi 1827387616 1505 HmvpSQ----AIVIDEIPLTPAGKL 1525
Cdd:cd05911    464 Y---KQlrggVVFVDEIPKSASGKI 485

FC-FACS_FadD_like

cd05936

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...

2567-3059

1.61e-59

Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 213.96 E-value: 1.61e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2567 LAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:cd05936      1 LADLLEEAARRFPDKTALIFM-GRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMIEDSGAVLGLSVLAsgdlpgqeFEwmrldddSVAAEIAAVPAGPITDAErlgevtaaNLAYVIYTSGS 2726
Cdd:cd05936     80 NPLYTPRELEHILNDSGAKALIVAVS--------FT-------DLLAAGAPLGERVALTPE--------DVAVLQYTSGT 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2727 TGRPKGVAVTHSGLANFARQESDRLNAGDNP--VVLGfASPSFDASVLeyllaTVNeGTLAYRpseaVGGEV--LERF-- 2800
Cdd:cd05936    137 TGVPKGAMLTHRNLVANALQIKAWLEDLLEGddVVLA-ALPLFHVFGL-----TVA-LLLPLA----LGATIvlIPRFrp 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2801 ------IAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTIGITI 2866
Cdd:cd05936    206 igvlkeIRKHRVTIFPGVPTMYIALlnapefKKRDFSSLRLCISGGAPLPVEVAERFEELTgvPIVEGYGLTETSPVVAV 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2867 SSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVV 2946
Cdd:cd05936    286 NPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEETAEAFVDG--------WLRTGDIG 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2947 RWtpDTDtGGLTLEytGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVA-TALAAYIVPVDGA-VEVSELK 3024
Cdd:cd05936    358 YM--DED-GYFFIV--DRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSgEAVKAFVVLKEGAsLTEEEII 432

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1827387616 3025 AFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05936    433 AFCREQLAGYKVPRQVEFRDELPKSAVGKILRREL 467

FACL_FadD13-like

cd17631

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...

2571-3056

2.09e-59

Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 212.47 E-value: 2.09e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2571 FRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDY 2650
Cdd:cd17631      1 LRRRARRHPDRTALVFG-GRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2651 PAERVASMIEDSGAvlglSVLasgdlpgqefewmrLDDdsvaaeiaavpagpitdaerlgevtaanLAYVIYTSGSTGRP 2730
Cdd:cd17631     80 TPPEVAYILADSGA----KVL--------------FDD----------------------------LALLMYTSGTTGRP 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2731 KGVAVTH-SGLANFARQESDR-LNAGDNPVVLGfasPSFDASVLE-YLLATVNEGTLAYRPSEAVGGEVLeRFIAEHGAT 2807
Cdd:cd17631    114 KGAMLTHrNLLWNAVNALAALdLGPDDVLLVVA---PLFHIGGLGvFTLPTLLRGGTVVILRKFDPETVL-DLIERHRVT 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2808 HTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRW-APATELHNLYGPTETTIGITIssaMRPGDPVRL-- 2878
Cdd:cd17631    190 SFFLVPTMIQALlqhprfATTDLSSLRAVIYGGAPMPERLLRALqARGVKFVQGYGMTETSPGVTF---LSPEDHRRKlg 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2879 --GGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRwtPDtDTGG 2956
Cdd:cd17631    267 saGRPVFFVEVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEATAAAFRDG--------WFHTGDLGR--LD-EDGY 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2957 LTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATALaayIVPVDGA-VEVSELKAFAGGRL 3031
Cdd:cd17631    336 LYI--VDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPdekwGEAVVAV---VVPRPGAeLDEDELIAHCRERL 410

                          490       500
                   ....*....|....*....|....*
gi 1827387616 3032 PAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd17631    411 ARYKIPKSVEFVDALPRNATGKILK 435

C_PKS-NRPS

cd20483

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

570-996

7.34e-59

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHXXXD motif. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380471 [Multi-domain] Cd Length: 430 Bit Score: 210.96 E-value: 7.34e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLP---VAVAR 646
Cdd:cd20483      1 PRPMSTFQRRLWFLHNFLEDKTFLNLLLVCHIKGKPDVNLLQKALSELVRRHEVLRTAYFEGDDFGEQQVLDdpsFHLIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  647 EQLDwREADSVESLVRSTTE----GFDVSTQMPLRGRFHRDGAGLHVALTM-HHIAMDGQSIPVLARDLMSAYAA-RAEG 720
Cdd:cd20483     81 IDLS-EAADPEAALDQLVRNlrrqELDIEEGEVIRGWLVKLPDEEFALVLAsHHIAWDRGSSKSIFEQFTALYDAlRAGR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  721 RTGGLPVLDVQYADYALWQQSVLGDADDETSvlgeqLSHWRRVLAGLP-AVTDLPM-DRPRPAVLGTAGATVTVEFDDDL 798
Cdd:cd20483    160 DLATVPPPPVQYIDFTLWHNALLQSPLVQPL-----LDFWKEKLEGIPdASKLLPFaKAERPPVKDYERSTVEATLDKEL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  799 ADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNV 878
Cdd:cd20483    235 LARMKRICAQHAVTPFMFLLAAFRAFLYRYTEDEDLTIGMVDGDRPHPDFDDLVGFFVNMLPIRCRMDCDMSFDDLLEST 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  879 RTTVLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYteptvnDVAGleasgiQAAPVDTGvvnaKFDLTvavRARS 958
Cdd:cd20483    315 KTTCLEAYEHSAVPFDYIVDALDVPRSTSHFPIGQIAVNY------QVHG------KFPEYDTG----DFKFT---DYDH 375

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  959 GGTPMAADFI----------------YATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd20483    376 YDIPTACDIAleaeedpdggldlrleFSTTLYDSADMERFLDNFVTFLTSVIRD 429

Acs

COG0365

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

2569-3059

1.93e-58

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 213.82 E-value: 1.93e-58

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVV----DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:COG0365     13 NCLDRHAEGRGDKVALIwegeDGEERTLTYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHS 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSGAVLglsVLASGDL--PGQEFEWMRLDDDSVAA------------EIAAVPAGPITDAERL- 2709
Cdd:COG0365     93 PVFPGFGAEALADRIEDAEAKV---LITADGGlrGGKVIDLKEKVDEALEElpslehvivvgrTGADVPMEGDLDWDELl 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2710 --------GEVTAAN-LAYVIYTSGSTGRPKGVAVTHSGLANFARQESD---RLNAGDnpVVLGFASPSFdASVLEYLL- 2776
Cdd:COG0365    170 aaasaefePEPTDADdPLFILYTSGTTGKPKGVVHTHGGYLVHAATTAKyvlDLKPGD--VFWCTADIGW-ATGHSYIVy 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2777 ------ATV--NEGTLAYrPSeavgGEVLERFIAEHGATHTFLTPSVLSTM---DPTAV-----PSLRVIAAGGEAVPQP 2840
Cdd:COG0365    247 gpllngATVvlYEGRPDF-PD----PGRLWELIEKYGVTVFFTAPTAIRALmkaGDEPLkkydlSSLRLLGSAGEPLNPE 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2841 IVDRWAPAT--ELHNLYGPTETTiGITISSamRPGDPVR---LGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALS-- 2913
Cdd:COG0365    322 VWEWWYEAVgvPIVDGWGQTETG-GIFISN--LPGLPVKpgsMGKPVPGYDVAVVDEDGNPVPPGEEGELVIKGPWPGmf 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2914 RGYLDRSGLTAERFTANPYGtagqrMYRTGDVVRWTPDtdtGGLTleYTGRSDDQVKLRGLRIELGEIEAVLAEHDAV-E 2992
Cdd:COG0365    399 RGYWNDPERYRETYFGRFPG-----WYRTGDGARRDED---GYFW--ILGRSDDVINVSGHRIGTAEIESALVSHPAVaE 468

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 2993 SAVVlGV----GGSVataLAAYIVPVDGAVE----VSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:COG0365    469 AAVV-GVpdeiRGQV---VKAFVVLKPGVEPsdelAKELQAHVREELGPYAYPREIEFVDELPKTRSGKIMRRLL 539

DCL_NRPS-like

cd19536

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

2107-2535

8.04e-58

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal fungal CT domains and Dual Epimerization/Condensation (E/C) domains; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type [D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L))], which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 207.69 E-value: 8.04e-58

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2107 WPMTPLQQGLFFQADLantvadHDAIDVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAEV 2186
Cdd:cd19536      2 YPLSSLQEGMLFHSLL------NPGGSVYLHNYTYTVGRRLNLDLLLEALQVLIDRHDILRTSFIEDGLGQPVQVVHRQA 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2187 TVPWSVIDLRAEDAAslDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGA--ELVVTNHHLLIDGWSSPLVLADLLSL 2264
Cdd:cd19536     76 QVPVTELDLTPLEEQ--LDPLRAYKEETKIRRFDLGRAPLVRAALVRKDERErfLLVISDHHSILDGWSLYLLVKEILAV 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2265 Y-ATGQTFTGSLPGTSG-RDFADHARAvaTADVEAGIAAWREVLAPVTEPTLVAPgHEPSADAPPRDHQFSIDVKVTERL 2342
Cdd:cd19536    154 YnQLLEYKPLSLPPAQPyRDFVAHERA--SIQQAASERYWREYLAGATLATLPAL-SEAVGGGPEQDSELLVSVPLPVRS 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2343 EALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVnPDATVVDVLTAVQN 2422
Cdd:cd19536    231 RSLAKRSGIPLSTLLLAAWALVLSRHSGSDDVVFGTVVHGRSEETTGAERLLGLFLNTLPLRVTL-SEETVEDLLKRAQE 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2423 DKVKVLDHQQIGLPRLVAQTGLPALFDTLAVYESFPVnVDSVAGIDASSAGGLKLVGAKTSdaTHYPLNLSASRRGAELA 2502
Cdd:cd19536    310 QELESLSHEQVPLADIQRCSEGEPLFDSIVNFRHFDL-DFGLPEWGSDEGMRRGLLFSEFK--SNYDVNLSVLPKQDRLE 386

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1827387616 2503 LKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19536    387 LKLAYNSQVLDEEQAQRLAAYYKSAIAELATAP 419

PRK06187

long-chain-fatty-acid--CoA ligase; Validated

2564-3067

1.54e-57

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 209.66 E-value: 1.54e-57

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAY 2643
Cdd:PRK06187     5 PLTIGRILRHGARKHPDKEAVYFD-GRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2644 VPIDPDYPAERVASMIEDSGAVL------GLSVLAS--GDLPGQEFeWMRLDDDSVAAEIAAVP-------AGPIT-DAE 2707
Cdd:PRK06187    84 HPINIRLKPEEIAYILNDAEDRVvlvdseFVPLLAAilPQLPTVRT-VIVEGDGPAAPLAPEVGeyeellaAASDTfDFP 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2708 RLGEVTAANLayvIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFAsPSF--DASVLEYLlATVNEGTL- 2784
Cdd:PRK06187   163 DIDENDAAAM---LYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDDVYLVIV-PMFhvHAWGLPYL-ALMAGAKQv 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2785 ---AYRPSEAVggevleRFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWA--PATELHN 2853
Cdd:PRK06187   238 iprRFDPENLL------DLIETERVTFFFAVPTIWQMLlkapraYFVDFSSLRLVIYGGAALPPALLREFKekFGIDLVQ 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2854 LYGPTETTIGITIS---SAMRPGDPVRL--GGPIGGVDLMVLDERLRPVPV--GMPGELYVAGGALSRGYLDRSGLTAER 2926
Cdd:PRK06187   312 GYGMTETSPVVSVLppeDQLPGQWTKRRsaGRPLPGVEARIVDDDGDELPPdgGEVGEIIVRGPWLMQGYWNRPEATAET 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2927 FTANpygtagqrMYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GG 3001
Cdd:PRK06187   392 IDGG--------WLHTGDVGYIDED---GYLYI--TDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVpdekwGE 458

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 3002 SVAtalaAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAG 3067
Cdd:PRK06187   459 RPV----AVVVLKPGAtLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLREQYAEGK 521

A_NRPS_acs4

cd17654

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...

2-468

4.81e-57

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 206.17 E-value: 4.81e-57

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:cd17654     18 SYADLAEKISNLSNFLRKKFQTEERAIGLRCDRGTESPVAILAILFLGAAYAPIDPASPEQRSLTVMKKCHVSYLLQNKE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEARSRFDDivdvhvldisspgdadldEEEFAGPTrPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTA 161
Cdd:cd17654     98 LDNAPLSFTPE------------------HRHFNIRT-DECLAYVIHTSGTTGTPKIVAVPHKCILPNIQHFRSLFNITS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  162 RDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLAD-LIRRHGVTVIHFVPAMLAAF------NEVLGAgv 234
Cdd:cd17654    159 EDILFLTSPLTFDPSVVEIFLSLSSGATLLIVPTSVKVLPSKLADiLFKRHRITVLQATPTLFRRFgsqsikSTVLSA-- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  235 geLTSLRLIQTGGEAL-TPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREv 313
Cdd:cd17654    237 --TSSLRVLALGGEPFpSLVILSSWRGKGNRTRIFNIYGITEVSCWALAYKVPEEDSPVQLGSPLLGTVIEVRDQNGSE- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  314 pigVPGELYLGGvqLARGYagrpdltaerFVADPFGEPGARLYRTGDRARwNRDGEIEYLGRTDFQVKLRGQRLELGEVE 393
Cdd:cd17654    314 ---GTGQVFLGG--LNRVC----------ILDDEVTVPKGTMRATGDFVT-VKDGELFFLGRKDSQIKRRGKRINLDLIQ 377

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616  394 AALAAAPGVLHAAAAVVDgpgGQQLVGYLAPADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd17654    378 QVIESCLGVESCAVTLSD---QQRLIAFIVGESSSSRIHKELQLTLLSSHAIPDTFVQIDKLPLTSHGKVDKSEL 449

Acs

COG0365

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

1049-1530

7.03e-57

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 209.20 E-value: 7.03e-57

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1049 DPDHPALICDGTEMD-----YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:COG0365     22 RGDKVALIWEGEDGEertltYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVFPGFGAE 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGITDASTR--------------ARLGESSCE----------------WVDLADLEAEAESGDDITDT 1173
Cdd:COG0365    102 ALADRIEDAEAKVLITADGGLrggkvidlkekvdeALEELPSLEhvivvgrtgadvpmegDLDWDELLAAASAEFEPEPT 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1174 ERNgsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTpedEPDTRILHVASPSF---DASMFEMAWAip 1250
Cdd:COG0365    182 DAD------DPLFILYTSGTTGKPKGVVHTHGGYLVHAATTAKYVLDL---KPGDVFWCTADIGWatgHSYIVYGPLL-- 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1251 AGHTLVIAPQADFAGDA--LATVLERDEVTDMIITPSVLATV----DPERAQY----VRNLATGGEACPPELVERWSER- 1319
Cdd:COG0365    251 NGATVVLYEGRPDFPDPgrLWELIEKYGVTVFFTAPTAIRALmkagDEPLKKYdlssLRLLGSAGEPLNPEVWEWWYEAv 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1320 GRRIFNCYGPTEAT-VWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYL--STAGLARGYLGRPGQTAV 1396
Cdd:COG0365    331 GVPIVDGWGQTETGgIFISNLPGLPVKPGSMGKPVPGYDVAVVDEDGNPVPPGEEGELVIkgPWPGMFRGYWNDPERYRE 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1397 SFVADPFGepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhTE 1476
Cdd:COG0365    411 TYFGRFPG-----WYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAVAEAAVVGVPDEIRG---QV 482

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1477 VVAYLVAKPGATiDSAAVLDEAAQH----LAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:COG0365    483 VKAFVVLKPGVE-PSDELAKELQAHvreeLGPYAYPREIEFVDELPKTRSGKIMRRLL 539

DCL_NRPS

cd19543

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

571-996

1.52e-56

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 203.97 E-value: 1.52e-56

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  571 LPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRT--VYPSVGAaPVQDVLP-VAVARE 647
Cdd:cd19543      2 YPLSPMQEGMLFHSLLDPGSGAYVEQMVITLEGPLDPDRFRAAWQAVVDRHPILRTsfVWEGLGE-PLQVVLKdRKLPWR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  648 QLDWREADSVES-------LVRSTTEGFDVSTQMPLRGRFHRDGAGLHVAL-TMHHIAMDGQSIPVLARDLMSAYAARAE 719
Cdd:cd19543     81 ELDLSHLSEAEQeaelealAEEDRERGFDLARAPLMRLTLIRLGDDRYRLVwSFHHILLDGWSLPILLKELFAIYAALGE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  720 GRTGGLPVlDVQYADYALWqqsvLGDADDEtsvlgEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLA 799
Cdd:cd19543    161 GQPPSLPP-VRPYRDYIAW----LQRQDKE-----AAEAYWREYLAGFEEPTPLPKELPADADGSYEPGEVSFELSAELT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  800 DRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRND--PALEELIGMFVNTLLLRTQVDPGHSVGDLLGN 877
Cdd:cd19543    231 ARLQELARQHGVTLNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAelPGIETMVGLFINTLPVRVRLDPDQTVLELLKD 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  878 VRTTVLDAFANDQVQFDElIEAlapeRSSSHQPLAQIAFTYTEPTVNDVAGLEAsgiQAAPVDTGVVNAK----FDLTVA 953
Cdd:cd19543    311 LQAQQLELREHEYVPLYE-IQA----WSEGKQALFDHLLVFENYPVDESLEEEQ---DEDGLRITDVSAEeqtnYPLTVV 382

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1827387616  954 VrarSGGTPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19543    383 A---IPGEELTIKLSYDAEVFDEATIERLLGHLRRVLEQVAAN 422

A_NRPS_acs4

cd17654

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...

1050-1530

7.28e-56

Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 202.70 E-value: 7.28e-56

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMD----YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRI 1125
Cdd:cd17654      1 PDRPALIIDQTTSDttvsYADLAEKISNLSNFLRKKFQTEERAIGLRCDRGTESPVAILAILFLGAAYAPIDPASPEQRS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1126 AYMLEDSGatvgitdastrarlgesscewvdLADLEAEAESGD---DITDTERNGSVRLT-NLAYLIYTSGSTGRPKAVG 1201
Cdd:cd17654     81 LTVMKKCH-----------------------VSYLLQNKELDNaplSFTPEHRHFNIRTDeCLAYVIHTSGTTGTPKIVA 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1202 VSHTGIVDFVNSLAKITTGTPEDepdtrILHVASP-SFDASMFEMAWAIPAGHTLVIAPQADFAGDA-LATVL-ERDEVT 1278
Cdd:cd17654    138 VPHKCILPNIQHFRSLFNITSED-----ILFLTSPlTFDPSVVEIFLSLSSGATLLIVPTSVKVLPSkLADILfKRHRIT 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1279 DMIITPSVLATVDPERAQY--------VRNLATGGEACPPELV-ERWSERGRR--IFNCYGPTEATVWATRSRMTAGK-P 1346
Cdd:cd17654    213 VLQATPTLFRRFGSQSIKStvlsatssLRVLALGGEPFPSLVIlSSWRGKGNRtrIFNIYGITEVSCWALAYKVPEEDsP 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1347 VTIGKPVDGFTVRVLDGRLHEVPqgvvGELYLstAGLARGYlgrpgqtavsFVADPFGEPGARMYATGDLVRVaKGGNLE 1426
Cdd:cd17654    293 VQLGSPLLGTVIEVRDQNGSEGT----GQVFL--GGLNRVC----------ILDDEVTVPKGTMRATGDFVTV-KDGELF 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1427 FAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRggrkhteVVAYLVAKPgatiDSAAVLDEAAQH-LAAH 1505
Cdd:cd17654    356 FLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAVTLSDQQR-------LIAFIVGES----SSSRIHKELQLTlLSSH 424

                          490       500
                   ....*....|....*....|....*
gi 1827387616 1506 MVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd17654    425 AIPDTFVQIDKLPLTSHGKVDKSEL 449

A_NRPS_acs4

cd17654

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...

2579-3059

8.31e-56

Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 202.70 E-value: 8.31e-56

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAV---VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERV 2655
Cdd:cd17654      1 PDRPALiidQTTSDTTVSYADLAEKISNLSNFLRKKFQTEERAIGLRCDRGTESPVAILAILFLGAAYAPIDPASPEQRS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2656 ASMIEDSGavlgLSVLASGDLPGQEFEWMrldddsvaaeiaavpagpITDAERLGEVTAANLAYVIYTSGSTGRPKGVAV 2735
Cdd:cd17654     81 LTVMKKCH----VSYLLQNKELDNAPLSF------------------TPEHRHFNIRTDECLAYVIHTSGTTGTPKIVAV 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2736 THSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEA-VGGEVLERFIAE-HGATHTFLTP 2813
Cdd:cd17654    139 PHKCILPNIQHFRSLFNITSEDILFLTSPLTFDPSVVEIFLSLSSGATLLIVPTSVkVLPSKLADILFKrHRITVLQATP 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2814 SVL----------STMdpTAVPSLRVIAAGGEAVPQPIVDR-WAPA---TELHNLYGPTETTIGITISSAMRPGDPVRLG 2879
Cdd:cd17654    219 TLFrrfgsqsiksTVL--SATSSLRVLALGGEPFPSLVILSsWRGKgnrTRIFNIYGITEVSCWALAYKVPEEDSPVQLG 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2880 GPIGGVDLMVLDERlrpvpvGMPGELYVAGGALSRGYldrsgltaerFTANPYGTAGQRMYRTGDVVRWTPDTdtggltL 2959
Cdd:cd17654    297 SPLLGTVIEVRDQN------GSEGTGQVFLGGLNRVC----------ILDDEVTVPKGTMRATGDFVTVKDGE------L 354

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2960 EYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLgvgGSVATALAAYIV-PVDGAVEVSELKAFaggRLPAYMVPS 3038
Cdd:cd17654    355 FFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAVT---LSDQQRLIAFIVgESSSSRIHKELQLT---LLSSHAIPD 428

                          490       500
                   ....*....|....*....|.
gi 1827387616 3039 SFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd17654    429 TFVQIDKLPLTSHGKVDKSEL 449

PRK04813

D-alanine--poly(phosphoribitol) ligase subunit DltA;

50-468

4.55e-55

D-alanine--poly(phosphoribitol) ligase subunit DltA;

Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 202.05 E-value: 4.55e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   50 GH-FVPLDEQLPVDRARYMVRTAGVRLVVVTSDgeaearsrFD-DIVDVHVLDISspgdaDLDEEEFAGPTRPANAA--- 124
Cdd:PRK04813    76 GHaYIPVDVSSPAERIEMIIEVAKPSLIIATEE--------LPlEILGIPVITLD-----ELKDIFATGNPYDFDHAvkg 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  125 ----FTLFTSGSTGRPKAVVITHrgiANRLA-AD--IEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGR 197
Cdd:PRK04813   143 ddnyYIIFTSGTTGKPKGVQISH---DNLVSfTNwmLEDFALPEGPQFLNQAPYSFDLSVMDLYPTLASGGTLVALPKDM 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  198 HGDPVHLADLIRRHGVTVIHFVPA------MLAAFNEVLgagvgeLTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQY 271
Cdd:PRK04813   220 TANFKQLFETLPQLPINVWVSTPSfadmclLDPSFNEEH------LPNLTHFLFCGEELPHKTAKKLLERFPSATIYNTY 293

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  272 GPAEASIVVTIHRVTQD-----DRViPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFvad 346
Cdd:PRK04813   294 GPTEATVAVTSIEITDEmldqyKRL-PIGYAKPDSPLLIIDEEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEAF--- 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  347 pFGEPGARLYRTGDRARWNrDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDgPGG--QQLVGYLAP 424
Cdd:PRK04813   370 -FTFDGQPAYHTGDAGYLE-DGLLFYQGRIDFQIKLNGYRIELEEIEQNLRQSSYVESAVVVPYN-KDHkvQYLIAYVVP 446

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616  425 ADVDVDTVAATT-------AELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK04813   447 KEEDFEREFELTkaikkelKERLMEYMIPRKFIYRDSLPLTPNGKIDRKAL 497

PRK07656

long-chain-fatty-acid--CoA ligase; Validated

1035-1532

1.11e-54

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 201.29 E-value: 1.11e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1035 EAGTLIDVLAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAY 1113
Cdd:PRK07656     3 EWMTLPELLARAaRRFGDKEAYVFGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1114 VPVDPAYPADRIAYMLEDSGATVGI-------TDASTRARLGE----SSCEWVDLADLEAEAESGDDI----TDTERNGS 1178
Cdd:PRK07656    83 VPLNTRYTADEAAYILARGDAKALFvlglflgVDYSATTRLPAlehvVICETEEDDPHTEKMKTFTDFlaagDPAERAPE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1179 VRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILhVASPSFDASMFEMAWAIP--AGHTLV 1256
Cdd:PRK07656   163 VDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGD----RYL-AANPFFHVFGYKAGVNAPlmRGATIL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1257 IAPQadFAGDALATVLERDEVTdmiitpsVLATVD---------PERAQY----VRNLATGGEACPPELVERWSERgrri 1323
Cdd:PRK07656   238 PLPV--FDPDEVFRLIETERIT-------VLPGPPtmynsllqhPDRSAEdlssLRLAVTGAASMPVALLERFESE---- 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNC------YGPTEATVWAT-----RSRMTAgkPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPG 1392
Cdd:PRK07656   305 LGVdivltgYGLSEASGVTTfnrldDDRKTV--AGTIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDDPE 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1393 QTAVSFVADPFgepgarMYaTGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGr 1472
Cdd:PRK07656   383 ATAAAIDADGW------LH-TGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDERLG- 454

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1473 khtEVV-AYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK07656   455 ---EVGkAYVVLKPGAELTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALRE 512

PRK06187

long-chain-fatty-acid--CoA ligase; Validated

1050-1535

2.87e-54

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 200.03 E-value: 2.87e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK06187    20 PDKEAVYFDGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVLHPINIRLKPEEIAYIL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAST-------RARL--------------GESSCEWVDLADLEAEAESGDDITDTERNgsvrltNLAYLI 1188
Cdd:PRK06187   100 NDAEDRVVLVDSEFvpllaaiLPQLptvrtvivegdgpaAPLAPEVGEYEELLAAASDTFDFPDIDEN------DAAAML 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1189 YTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILhVASPSFDAsmfeMAWAIP-----AGHTLVIAPQADF 1263
Cdd:PRK06187   174 YTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDD----VYL-VIVPMFHV----HAWGLPylalmAGAKQVIPRRFDP 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1264 agDALATVLERDEVTDMIITPSVLATV--DPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWA 1336
Cdd:PRK06187   245 --ENLLDLIETERVTFFFAVPTIWQMLlkAPRAYFVdfssLRLVIYGGAALPPALLREFKEKfGIDLVQGYGMTETSPVV 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1337 TRSRMTAG------KPVTIGKPVDGFTVRVLDGRLHEVP--QGVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgepga 1408
Cdd:PRK06187   323 SVLPPEDQlpgqwtKRRSAGRPLPGVEARIVDDDGDELPpdGGEVGEIIVRGPWLMQGYWNRPEATAETIDGG------- 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1409 rMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGAT 1488
Cdd:PRK06187   396 -WLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVPDEKWGE---RPVAVVVLKPGAT 471

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616 1489 IDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHA 1535
Cdd:PRK06187   472 LDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLREQYA 518

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

573-809

7.78e-54

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 189.48 E-value: 7.78e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  573 LSRAQRRMWFLnqfDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLP---VAVAREQL 649
Cdd:COG4908      1 LSPAQKRFLFL---EPGSNAYNIPAVLRLEGPLDVEALERALRELVRRHPALRTRFVEEDGEPVQRIDPdadLPLEVVDL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  650 -----DWREADSVESLVRSTTEGFDVSTQMPLRGRFHRDGAGLHV-ALTMHHIAMDGQSIPVLARDLMSAYAARAEGRTG 723
Cdd:COG4908     78 salpePEREAELEELVAEEASRPFDLARGPLLRAALIRLGEDEHVlLLTIHHIISDGWSLGILLRELAALYAALLEGEPP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  724 GLPVLDVQYADYALWQQSVLGDADdetsvLGEQLSHWRRVLAGLPAVTDLPMDRPRPAVLGTAGATVTVEFDDDLADRVD 803
Cdd:COG4908    158 PLPELPIQYADYAAWQRAWLQSEA-----LEKQLEYWRQQLAGAPPVLELPTDRPRPAVQTFRGATLSFTLPAELTEALK 232


                   ....*.
gi 1827387616  804 VLARSN 809
Cdd:COG4908    233 ALAKAH 238

FACL_DitJ_like

cd05934

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1059-1531

4.54e-52

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.

Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 190.97 E-value: 4.54e-52

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1059 GTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGI 1138
Cdd:cd05934      1 GRRWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1139 TDastrarlgesscewvdladleaeaesgdditdterngsvrltnLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKIT 1218
Cdd:cd05934     81 VD-------------------------------------------PASILYTSGTTGPPKGVVITHANLTFAGYYSARRF 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1219 TGTPEDepdtrILHVASPSF--DASMFEMAWAIPAGHTLVIAPQadFAGDALATVLERDEVTDMIITPSVLATV--DPER 1294
Cdd:cd05934    118 GLGEDD-----VYLTVLPLFhiNAQAVSVLAALSVGATLVLLPR--FSASRFWSDVRRYGATVTNYLGAMLSYLlaQPPS 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1295 AQYVRNL--ATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQG 1371
Cdd:cd05934    191 PDDRAHRlrAAYGAPNPPELHEEFEERfGVRLLEGYGMTETIVGVIGPRDEPRRPGSIGRPAPGYEVRIVDDDGQELPAG 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1372 VVGELYLSTA---GLARGYLGRPGQTAVSFvadpfgEPGarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIE 1448
Cdd:cd05934    271 EPGELVIRGLrgwGFFKGYYNMPEATAEAM------RNG--WFHTGDLGYRDADGFFYFVDRKKDMIRRRGENISSAEVE 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1449 AVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRA 1528
Cdd:cd05934    343 RAILRHPAVREAAVVAVPDEVGED---EVKAVVVLRPGETLDPEELFAFCEGQLAYFKVPRYIRFVDDLPKTPTEKVAKA 419


                   ...
gi 1827387616 1529 ALP 1531
Cdd:cd05934    420 QLR 422

ligase_PEP_1

TIGR03098

acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an ...

2566-3059

2.36e-51

acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an AMP-binding domain (pfam00501) associated with acyl CoA-ligases. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present next to a decarboxylase enzyme. A number of sequences from Burkholderia species also hit this model, but the genomic context is obviously different. The hypothesis of a constant substrate for this family is only strong where the exosortase context is present.

Pssm-ID: 211788 [Multi-domain] Cd Length: 517 Bit Score: 191.53 E-value: 2.36e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:TIGR03098    1 LLHHLLEDAAARLPDATALVHH-DRTLTYAALSERVLALASGLRGLGLARGERVAIYLDKRLETVTAMFGAALAGGVFVP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGAVL------GLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPIT--------DAERLGE 2711
Cdd:TIGR03098   80 INPLLKAEQVAHILADCNVRLlvtsseRLDLLHPALPGCHDLRTLIIVGDPAHASEGHPGEEPASwpkllalgDADPPHP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2712 VTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASvleyllatVNEGTLAYrpseA 2791
Cdd:TIGR03098  160 VIDSDMAAILYTSGSTGRPKGVVLSHRNLVAGAQSVATYLENRPDDRLLAVLPLSFDYG--------FNQLTTAF----Y 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 VGGEV----------LERFIAEHGATHTFLTPSV---LSTMD--PTAVPSLRVIAAGGEAVPQPIVDR---WAPATELHN 2853
Cdd:TIGR03098  228 VGATVvlhdyllprdVLKALEKHGITGLAAVPPLwaqLAQLDwpESAAPSLRYLTNSGGAMPRATLSRlrsFLPNARLFL 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2854 LYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPyG 2933
Cdd:TIGR03098  308 MYGLTEAFRSTYLPPEEVDRRPDSIGKAIPNAEVLVLREDGSECAPGEEGELVHRGALVAMGYWNDPEKTAERFRPLP-P 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2934 TAGQrMYRTGDVVrWTPDT---DTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGG-SVATALAA 3009
Cdd:TIGR03098  387 FPGE-LHLPELAV-WSGDTvrrDEEGF-LYFVGRRDEMIKTSGYRVSPTEVEEVAYATGLVAEAVAFGVPDpTLGQAIVL 463

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 3010 YIVP-VDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:TIGR03098  464 VVTPpGGEELDRAALLAECRARLPNYMVPALIHVRQALPRNANGKIDRKAL 514

Acs

COG0365

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

2-468

4.29e-51

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 191.86 E-value: 4.29e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTSD 81
Cdd:COG0365     41 TYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVFPGFGAEALADRIEDAEAK-VLITAD 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 G------EAEARSRFDDIVD-----VHVL-------DISSPGDADLDE------EEF-AGPTRPANAAFTLFTSGSTGRP 136
Cdd:COG0365    120 GglrggkVIDLKEKVDEALEelpslEHVIvvgrtgaDVPMEGDLDWDEllaaasAEFePEPTDADDPLFILYTSGTTGKP 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  137 KAVVITHRGIANRLAADIE-QYDLTARDVFLYKAP---ITFDVSVreIFLPIAIGATLVIAEpGR--HGDPVHLADLIRR 210
Cdd:COG0365    200 KGVVHTHGGYLVHAATTAKyVLDLKPGDVFWCTADigwATGHSYI--VYGPLLNGATVVLYE-GRpdFPDPGRLWELIEK 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  211 HGVTVIHFVPAMLAAFnevLGAGVGE-----LTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAE-ASIVVTIHR 284
Cdd:COG0365    277 YGVTVFFTAPTAIRAL---MKAGDEPlkkydLSSLRLLGSAGEPLNPEVWEWWYEAV-GVPIVDGWGQTEtGGIFISNLP 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  285 VTQddrVIPiGTPTRRV---SARVLDAALREVPIGVPGELYLGG--VQLARGYAGRPDLTAERFVADPFGepgarLYRTG 359
Cdd:COG0365    353 GLP---VKP-GSMGKPVpgyDVAVVDEDGNPVPPGEEGELVIKGpwPGMFRGYWNDPERYRETYFGRFPG-----WYRTG 423

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  360 DRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGP---GGQQLVGYLAPADvDVDTVAATT 436
Cdd:COG0365    424 DGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAV--AEAAVVGVPdeiRGQVVKAFVVLKP-GVEPSDELA 500

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1827387616  437 AEL-------LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:COG0365    501 KELqahvreeLGPYAYPREIEFVDELPKTRSGKIMRRLL 539

BCL_4HBCL

cd05959

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...

1050-1530

1.21e-50

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.

Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 189.12 E-value: 1.21e-50

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd05959     18 GDKTAFIDDAGSLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNTLLTPDDYAYYL 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDASTRARLG------ESSCEWVDLADLEAEAESGDDITDTERNGSVRLT-------NLAYLIYTSGSTGR 1196
Cdd:cd05959     98 EDSRARVVVVSGELAPVLAaaltksEHTLVVLIVSGGAGPEAGALLLAELVAAEAEQLKpaathadDPAFWLYSSGSTGR 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1197 PKAVGVSHTGIVDFVNSLAKITTGTPEDEpdtRILHVASPSF-----DASMFEMAwaipAGHTLVIAPQADfAGDALATV 1271
Cdd:cd05959    178 PKGVVHLHADIYWTAELYARNVLGIREDD---VCFSAAKLFFayglgNSLTFPLS----VGATTVLMPERP-TPAAVFKR 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1272 LERDEVTDMIITPSVLA--TVDPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAG 1344
Cdd:cd05959    250 IRRYRPTVFFGVPTLYAamLAAPNLPSRdlssLRLCVSAGEALPAEVGERWKARfGLDILDGIGSTEMLHIFLSNRPGRV 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 KPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVadpfGEpgarMYATGDLVRVAKGGN 1424
Cdd:cd05959    330 RYGTTGKPVPGYEVELRDEDGGDVADGEPGELYVRGPSSATMYWNNRDKTRDTFQ----GE----WTRTGDKYVRDDDGF 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1425 LEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGgrkHTEVVAYLVAKPGATiDSAAVLDEAAQH--- 1501
Cdd:cd05959    402 YTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDG---LTKPKAFVVLRPGYE-DSEALEEELKEFvkd 477

                          490       500       510
                   ....*....|....*....|....*....|
gi 1827387616 1502 -LAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05959    478 rLAPYKYPRWIVFVDELPKTATGKIQRFKL 507

beta-lac_NRPS

cd19547

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis ...

2106-2535

4.23e-50

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis NocB which exhibits an unusual cyclization to form beta-lactam rings in pro-nocardicin G synthesis; Nocardia uniformis NRPS NocB acts centrally in the biosynthesis of the nocardicin monocyclic beta-lactam antibiotics. Along with another NRPS NocA, it mediates an unusual cyclization to form beta-lactam rings in the synthesis of the beta-lactam-containing pentapeptide pro-nocardicin G. This small subfamily is related to DCL-type Condensation (C) domains, which catalyze condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; domains belonging to this subfamily have an HHHxxxD motif at the active site.

Pssm-ID: 380469 [Multi-domain] Cd Length: 422 Bit Score: 185.21 E-value: 4.23e-50

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2106 VWPMTPLQQGLFFQADLAntvADHDAidvYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAE 2185
Cdd:cd19547      1 VYPLAPMQEGMLFRGLFW---PDSDA---YFNQNVLELVGGTDEDVLREAWRRVADRYEILRTGFTWRDRAEPLQYVRDD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2186 VTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGAE-LVVTNHHLLIDGWSSPLVLADLLSL 2264
Cdd:cd19547     75 LAPPWALLDWSGEDPDRRAELLERLLADDRAAGLSLADCPLYRLTLVRLGGGRHyLLWSHHHILLDGWCLSLIWGDVFRV 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2265 Y---ATGQTFTGSlPGTSGRDFADHARAvATADVEAGIAAWREVLAPVTePTlvapghePSADAPP-RDHQFSIDV---- 2336
Cdd:cd19547    155 YeelAHGREPQLS-PCRPYRDYVRWIRA-RTAQSEESERFWREYLRDLT-PS-------PFSTAPAdREGEFDTVVhefp 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2337 -KVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVD 2415
Cdd:cd19547    225 eQLTRLVNEAARGYGVTTNAISQAAWSMLLALQTGARDVVHGLTIAGRPPELEGSEHMVGIFINTIPLRIRLDPDQTVTG 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2416 VLTAVQNDKVKVLDHQQIGLPRLVAQTGLPAL-----FDTLAVYESFPvnVDSVAGIDASsaggLKLVGAKTSDATHYPL 2490
Cdd:cd19547    305 LLETIHRDLATTAAHGHVPLAQIKSWASGERLsggrvFDNLVAFENYP--EDNLPGDDLS----IQIIDLHAQEKTEYPI 378

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 2491 NLSASRRgAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19547    379 GLIVLPL-QKLAFHFNYDTTHFTRAQVDRFIEVFRLLTEQLCRRP 422

BCL_like

cd05919

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...

1053-1530

8.65e-50

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.

Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 184.59 E-value: 8.65e-50

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1053 PALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDS 1132
Cdd:cd05919      2 TAFYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDC 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1133 GATVGITDAstrarlgesscewvdladleaeaesgDDItdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFVN 1212
Cdd:cd05919     82 EARLVVTSA--------------------------DDI--------------AYLLYSSGTTGPPKGVMHAHRDPLLFAD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1213 SLAKITTG-TPEDepdtRILHVASPSFDASMFEMAW-AIPAGHTLVIAPQADFAGDALATvLERDEVTDMIITPSVLATV 1290
Cdd:cd05919    122 AMAREALGlTPGD----RVFSSAKMFFGYGLGNSLWfPLAVGASAVLNPGWPTAERVLAT-LARFRPTVLYGVPTFYANL 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1291 DPERAQY------VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDG 1363
Cdd:cd05919    197 LDSCAGSpdalrsLRLCVSAGEALPRGLGERWMEHfGGPILDGIGATEVGHIFLSNRPGAWRLGSTGRPVPGYEIRLVDE 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1364 RLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVE 1443
Cdd:cd05919    277 EGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFNGG--------WYRTGDKFCRDADGWYTHAGRADDMLKVGGQWVS 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1444 LGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTevvAYLVAKPGATIDSA---AVLDEAAQHLAAHMVPSQAIVIDEIPLT 1520
Cdd:cd05919    349 PVEVESLIIQHPAVAEAAVVAVPESTGLSRLT---AFVVLKSPAAPQESlarDIHRHLLERLSAHKVPRRIAFVDELPRT 425

                          490
                   ....*....|
gi 1827387616 1521 PAGKLDRAAL 1530
Cdd:cd05919    426 ATGKLQRFKL 435

alpha_am_amid

TIGR03443

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...

13-573

1.24e-49

Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 195.67 E-value: 1.24e-49

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   13 LARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDR-----------ARYMVRTAGV--RLVVVT 79
Cdd:TIGR03443  283 LAHYLLKTGIKRGDVVMIYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARqtiylsvakprALIVIEKAGTldQLVRDY 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   80 SDGEAEARSRFDDI------------VDVHVLDISSPGDADLDEEE--FAGPTRPAnaafTL-FTSGSTGRPKAVVITHR 144
Cdd:TIGR03443  363 IDKELELRTEIPALalqddgslvggsLEGGETDVLAPYQALKDTPTgvVVGPDSNP----TLsFTSGSEGIPKGVLGRHF 438

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  145 GIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMla 224
Cdd:TIGR03443  439 SLAYYFPWMAKRFGLSENDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGRLAEWMAKYGATVTHLTPAM-- 516

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  225 afNEVLGAG-VGELTSLRLIQTGGEALTppvARDLMvRL----PGTRLQNQYGPAEASIVVTIHRV-----------TQD 288
Cdd:TIGR03443  517 --GQLLSAQaTTPIPSLHHAFFVGDILT---KRDCL-RLqtlaENVCIVNMYGTTETQRAVSYFEIpsrssdstflkNLK 590

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  289 DrVIPIGTPTRRVSARVLDAALREVPIGVP--GELYLGGVQLARGYAGRPDLTAERFVADPFGEPGA------------- 353
Cdd:TIGR03443  591 D-VMPAGKGMKNVQLLVVNRNDRTQTCGVGevGEIYVRAGGLAEGYLGLPELNAEKFVNNWFVDPSHwidldkennkper 669

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  354 --------RLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVV-DGPGGQQLVGYLAP 424
Cdd:TIGR03443  670 efwlgprdRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRrDKDEEPTLVSYIVP 749

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  425 AD---------VDVDTVAATTA---------EL-----------LPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEIAP 475
Cdd:TIGR03443  750 QDksdeleefkSEVDDEESSDPvvkglikyrKLikdireylkkkLPSYAIPTVIVPLKKLPLNPNGKVDKPALPFPDTAQ 829

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  476 TLYVPPG----------NADEETVAGLFAELL--GVERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPS 543
Cdd:TIGR03443  830 LAAVAKNrsasaadeefTETEREIRDLWLELLpnRPATISPDDSFFDLGGHSILATRMIFELRKKLNVELPLGLIFKSPT 909

                          650       660       670
                   ....*....|....*....|....*....|..
gi 1827387616  544 VRGLVHAVSG--RGSALPSVKRIEPRPERLPL 573
Cdd:TIGR03443  910 IKGFAKEVDRlkKGEELADEGDSEIEEEETVL 941

FC-FACS_FadD_like

cd05936

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...

1-468

1.20e-48

Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 182.38 E-value: 1.20e-48

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd05936     25 LTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLNPLYTPRELEHILNDSGAKALIVAV 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DgeaearsrFDDIVDvhvldisspgdADLDEEEFAGPTRPANAAFtLFTSGSTGRPKAVVITHRGI-ANRLAAD-IEQYD 158
Cdd:cd05936    105 S--------FTDLLA-----------AGAPLGERVALTPEDVAVL-QYTSGTTGVPKGAMLTHRNLvANALQIKaWLEDL 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  159 LTARDVFLYKAPI--TFDVSVrEIFLPIAIGATLVIaEPgrHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGE 236
Cdd:cd05936    165 LEGDDVVLAALPLfhVFGLTV-ALLLPLALGATIVL-IP--RFRPIGVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 LTSLRLIQTGGEALTPPVARDLmVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIG 316
Cdd:cd05936    241 FSSLRLCISGGAPLPVEVAERF-EELTGVPIVEGYGLTETSPVVAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPG 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  317 VPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGR-TD------FQVKLRgqrlel 389
Cdd:cd05936    320 EVGELWVRGPQVMKGYWNRPEETAEAFVDGWL--------RTGDIGYMDEDGYFFIVDRkKDmiivggFNVYPR------ 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  390 gEVEAALAAAPGVLHAAAA-VVDGPGGQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDR 465
Cdd:cd05936    386 -EVEEVLYEHPAVAEAAVVgVPDPYSGEAVKAFVVLKEgasLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILR 464


                   ...
gi 1827387616  466 RLL 468
Cdd:cd05936    465 REL 467

PRK07656

long-chain-fatty-acid--CoA ligase; Validated

2562-3061

1.88e-48

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 182.80 E-value: 1.88e-48

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2562 TDPVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGG 2641
Cdd:PRK07656     2 NEWMTLPELLARAARRFGDKEAYVFG-DQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2642 AYVPIDPDYPAERVASMIEDSGA--------VLGLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPI----TDAERL 2709
Cdd:PRK07656    81 VVVPLNTRYTADEAAYILARGDAkalfvlglFLGVDYSATTRLPALEHVVICETEEDDPHTEKMKTFTDFlaagDPAERA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2710 GEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRL--NAGDNPVVlgfASPSF-----DASVLEYLLatvNEG 2782
Cdd:PRK07656   161 PEVDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLglTEGDRYLA---ANPFFhvfgyKAGVNAPLM---RGA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2783 TLAYRPSEAVgGEVLERfIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNL-- 2854
Cdd:PRK07656   235 TILPLPVFDP-DEVFRL-IETERITVLPGPPTMYNSLlqhpdrSAEDLSSLRLAVTGAASMPVALLERFESELGVDIVlt 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 -YGPTETTIGITISsamRPGDPVRL-----GGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFT 2928
Cdd:PRK07656   313 gYGLSEASGVTTFN---RLDDDRKTvagtiGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDDPEATAAAID 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2929 ANPYgtagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVA 3004
Cdd:PRK07656   390 ADGW-------LHTGDLGRLDEE---GYLYI--VDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPderlGEVG 457

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 3005 TalaAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK07656   458 K---AYVVLKPGAeLTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALRE 512

EntE

COG1021

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...

2566-3059

2.12e-47

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 180.34 E-value: 2.12e-47

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGayVP 2645
Cdd:COG1021     26 TLGDLLRRRAERHPDRIAVVDG-ERRLSYAELDRRADRLAAGLLALGLRPGDRVVVQLPNVAEFVIVFFALFRAGA--IP 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPdYPAER---VASMIEDSGAVLglsVLASGDLPGqefewmrLDDDSVAAEIAA-VP----------AGPITDAERLGE 2711
Cdd:COG1021    103 VFA-LPAHRraeISHFAEQSEAVA---YIIPDRHRG-------FDYRALARELQAeVPslrhvlvvgdAGEFTSLDALLA 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2712 VTAANLAYVIYTS---------GSTGRPKGVAVTHSGLANFARQESD--RLNAGDN-----PVVLGF--ASPSFDAsVLe 2773
Cdd:COG1021    172 APADLSEPRPDPDdvaffqlsgGTTGLPKLIPRTHDDYLYSVRASAEicGLDADTVylaalPAAHNFplSSPGVLG-VL- 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2774 YLLATVnegTLAYRPSeavgGEVLERFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWAP 2847
Cdd:COG1021    250 YAGGTV---VLAPDPS----PDTAFPLIERERVTVTALVPPLALLWldaaerSRYDLSSLRVLQVGGAKLSPELARRVRP 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2848 A--TELHNLYGPTETTIGITissamRPGDPVRL-----GGPIGGVD-LMVLDERLRPVPVGMPGELYVAGGALSRGYLDR 2919
Cdd:COG1021    323 AlgCTLQQVFGMAEGLVNYT-----RLDDPEEVilttqGRPISPDDeVRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRA 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2920 SGLTAERFTANPYgtagqrmYRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV 2999
Cdd:COG1021    398 PEHNARAFTPDGF-------YRTGDLVRRTPDGY-----LVVEGRAKDQINRGGEKIAAEEVENLLLAHPAVHDAAVVAM 465

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 3000 -----GGSVAtalaAYIVPVDGAVEVSELKAFAGGR-LPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:COG1021    466 pdeylGERSC----AFVVPRGEPLTLAELRRFLRERgLAAFKLPDRLEFVDALPLTAVGKIDKKAL 527

C_NRPS-like

cd19066

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

2108-2535

3.56e-47

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 176.83 E-value: 3.56e-47

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQGLFFqadLANTVADHDAIDVYVTqtvLSLTGDVDPGRLRSALSELLARQRVLRSGFVRlPSGAAVTVVPAEVT 2187
Cdd:cd19066      3 PLSPMQRGMWF---LKKLATDPSAFNVAIE---MFLTGSLDLARLKQALDAVMERHDVLRTRFCE-EAGRYEQVVLDKTV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2188 VP-WSVIDLRaeDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGD-GAELVVTNHHLLIDGWSSPLVLADLLSLY 2265
Cdd:cd19066     76 RFrIEIIDLR--NLADPEARLLELIDQIQQTIYDLERGPLVRVALFRLADeRDVLVVAIHHIIVDGGSFQILFEDISSVY 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2266 --ATGQTFTGSLPGTSgrdFADHARAVATA----DVEAGIAAWREVLAPVTEPTLVAPGHEPS--ADAPPRDHQFSIDVK 2337
Cdd:cd19066    154 daAERQKPTLPPPVGS---YADYAAWLEKQleseAAQADLAYWTSYLHGLPPPLPLPKAKRPSqvASYEVLTLEFFLRSE 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2338 VTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDieGMESMVGMFINTIPAVVDVNPDATVVDVL 2417
Cdd:cd19066    231 ETKRLREVARESGTTPTQLLLAAFALALKRLTASIDVVIGLTFLNRPDE--AVEDTIGLFLNLLPLRIDTSPDATFPELL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2418 TAVQNDKVKVLDHQQIGLPRLVAQTGL------PALFDTLAVYESFPvnvdSVAGIDASSAGGLKLVgaKTSDATHYPLN 2491
Cdd:cd19066    309 KRTKEQSREAIEHQRVPFIELVRHLGVvpeapkHPLFEPVFTFKNNQ----QQLGKTGGFIFTTPVY--TSSEGTVFDLD 382

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 2492 LSAS-RRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19066    383 LEASeDPDGDLLLRLEYSRGVYDERTIDRFAERYMTALRQLIENP 427

FACL_like_6

cd05922

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1069-1530

7.82e-47

Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 176.48 E-value: 7.82e-47

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1069 TRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAA----YVPVDPAYPADRIAYMLEDSGATVGITDAS-- 1142
Cdd:cd05922      1 LGVSAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGRlglvFVPLNPTLKESVLRYLVADAGGRIVLADAGaa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1143 TRARLGESSC----EWVDladleaeaesGDDITDTERNGSVRLT---NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLA 1215
Cdd:cd05922     81 DRLRDALPASpdpgTVLD----------ADGIRAARASAPAHEVsheDLALLLYTSGSTGSPKLVRLSHQNLLANARSIA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1216 KITTGTPEDepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFaGDALATVLERDEVTDMIITPSVLA-----TV 1290
Cdd:cd05922    151 EYLGITADD----RALTVLPLSYDYGLSVLNTHLLRGATLVLTNDGVL-DDAFWEDLREHGATGLAGVPSTYAmltrlGF 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1291 DPERAQYVRNLATGGEACPPELVERWSE--RGRRIFNCYGPTEATvwatrSRMT-------AGKPVTIGKPVDGFTVRVL 1361
Cdd:cd05922    226 DPAKLPSLRYLTQAGGRLPQETIARLREllPGAQVYVMYGQTEAT-----RRMTylpperiLEKPGSIGLAIPGGEFEIL 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1362 DGRLHEVPQGVVGELYLSTAGLARGYLGRPgqtavSFVADPfGEPGARMYaTGDLVRVAKGGNLEFAGRADHQVKINGQR 1441
Cdd:cd05922    301 DDDGTPTPPGEPGEIVHRGPNVMKGYWNDP-----PYRRKE-GRGGGVLH-TGDLARRDEDGFLFIVGRRDRMIKLFGNR 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1442 VELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhteVVAYLVAKPGatIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTP 1521
Cdd:cd05922    374 ISPTEIEAAARSIGLIIEAAAVGLPDPLGEK----LALFVTAPDK--IDPKDVLRSLAERLPPYKVPATVRVVDELPLTA 447


                   ....*....
gi 1827387616 1522 AGKLDRAAL 1530
Cdd:cd05922    448 SGKVDYAAL 456

alpha_am_amid

TIGR03443

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...

768-1604

1.05e-46

Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 186.42 E-value: 1.05e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  768 PAVTDLPMDRPRPAVLGTAGATVTVEFDDDLAdrvdvlARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPa 847
Cdd:TIGR03443    9 PTLSVLPHDYLRPANNRLVEATYSLQLPSAEV------TAGGGSTPFIILLAAFAALVYRLTGDEDIVLGTSSNKSGRP- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  848 leeligmfvntLLLRTQVDPGHSVGDLLGNVRTTVLDAFANDQVQFDELIEAL-APERSSSHQPLAQIAFtyteptvndv 926
Cdd:TIGR03443   82 -----------FVLRLNITPELSFLQLYAKVSEEEKEGASDIGVPFDELSEHIqAAKKLERTPPLFRLAF---------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  927 agLEASGIQAAPVDTGVVNakfDLTVAVRarSGGTPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDDQNTAVGDIDI 1006
Cdd:TIGR03443  141 --QDAPDNQQTTYSTGSTT---DLTVFLT--PSSPELELSIYYNSLLFSSDRITIVADQLAQLLSAASSNPDEPIGKVSL 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1007 VGAARAKSVSAPVSARTPGAMVG-------RGGEVEAGTLIDVLAQRDLDPDHPAlicdgTEMDYDEFETRTNAIARALL 1079
Cdd:TIGR03443  214 ITPSQKSLLPDPTKDLDWSGFRGaihdifaDNAEKHPDRTCVVETPSFLDPSSKT-----RSFTYKQINEASNILAHYLL 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1080 ARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSG--ATVGITDASTRARLGESSCE---- 1153
Cdd:TIGR03443  289 KTGIKRGDVVMIYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARQTIYLSVAKprALIVIEKAGTLDQLVRDYIDkele 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1154 ------WVDLAD---LEA---EAESGDDITDTERNGSVRlTNL-------AYLIYTSGSTGRPKAVGVSHTGIVDFVNSL 1214
Cdd:TIGR03443  369 lrteipALALQDdgsLVGgslEGGETDVLAPYQALKDTP-TGVvvgpdsnPTLSFTSGSEGIPKGVLGRHFSLAYYFPWM 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1215 AKiTTGTPEDEPDTRILHVASPSFDASMFemawaIPA--GHTLVIaPQADFAGDA--LATVLERDEVTDMIITPS----- 1285
Cdd:TIGR03443  448 AK-RFGLSENDKFTMLSGIAHDPIQRDMF-----TPLflGAQLLV-PTADDIGTPgrLAEWMAKYGATVTHLTPAmgqll 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1286 -------------------VLATVDPERAQyvrNLAtggEACppelverwsergrRIFNCYGPTEA----TVWATRSR-- 1340
Cdd:TIGR03443  521 saqattpipslhhaffvgdILTKRDCLRLQ---TLA---ENV-------------CIVNMYGTTETqravSYFEIPSRss 581

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1341 -----------MTAGKPVtigKPVDGFTVRVLDgRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGA- 1408
Cdd:TIGR03443  582 dstflknlkdvMPAGKGM---KNVQLLVVNRND-RTQTCGVGEVGEIYVRAGGLAEGYLGLPELNAEKFVNNWFVDPSHw 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1409 --------------------RMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVgVEST 1468
Cdd:TIGR03443  658 idldkennkperefwlgprdRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTL-VRRD 736

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1469 RGGRKhtEVVAYLVAKP-GATIDSAAVLDEAA-------------------------QHLAAHMVPSQAIVIDEIPLTPA 1522
Cdd:TIGR03443  737 KDEEP--TLVSYIVPQDkSDELEEFKSEVDDEessdpvvkglikyrklikdireylkKKLPSYAIPTVIVPLKKLPLNPN 814

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1523 GKLDRAALPEPH-------APEPAEYVAPA--NPAEDNLARIVAGLLGEE--RVSVTESFFALGGDSImsiqlssaakaa 1591
Cdd:TIGR03443  815 GKVDKPALPFPDtaqlaavAKNRSASAADEefTETEREIRDLWLELLPNRpaTISPDDSFFDLGGHSI------------ 882

                          970
                   ....*....|...
gi 1827387616 1592 gihLSPREIFELK 1604
Cdd:TIGR03443  883 ---LATRMIFELR 892

FACL_FadD13-like

cd17631

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...

1-465

1.21e-46

Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 175.49 E-value: 1.21e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVvvts 80
Cdd:cd17631     21 LTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRLTPPEVAYILADSGAKVL---- 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrFDDIvdvhvldisspgdadldeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd17631     97 ---------FDDL------------------------------ALLMYTSGTTGRPKGAMLTHRNLLWNAVNALAALDLG 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFLP-IAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTS 239
Cdd:cd17631    138 PDDVLLVVAPLFHIGGLGVFTLPtLLRGGTVVIL---RKFDPETVLDLIERHRVTSFFLVPTMIQALLQHPRFATTDLSS 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASIVVTIHRVT-QDDRVIPIGTPTRRVSARVLDAALREVPIGVP 318
Cdd:cd17631    215 LRAVIYGGAPMPERLLRALQAR--GVKFVQGYGMTETSPGVTFLSPEdHRRKLGSAGRPVFFVEVRIVDPDGREVPPGEV 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAA 398
Cdd:cd17631    293 GEIVVRGPHVMAGYWNRPEATAAAFRDGWF--------HTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYE 364

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  399 APGVlhAAAAVV---DGPGGQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDR 465
Cdd:cd17631    365 HPAV--AEVAVIgvpDEKWGEAVVAVVVPRPgaeLDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435

C_PKS-NRPS_PksJ-like

cd20484

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

570-996

3.08e-46

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs), similar to Bacillus subtilis PksJ; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Members of this subfamily have the typical C-domain HHxxxD motif. PksJ is involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is important in secondary metabolism. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380472 [Multi-domain] Cd Length: 430 Bit Score: 174.04 E-value: 3.08e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDV---LPVAVAR 646
Cdd:cd20484      1 RSPLSEGQKGLWMLQKMSPEMSAYNVPLCFRFSSKLDVEKFKQACQFVLEQHPILKSVIEEEDGVPFQKIepsKPLSFQE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  647 EQLDWREADSVESLVRS-TTEGFDVStQMPLRgRFH---RDGAGLHVALTMHHIAMDGQSIPVLARDLMSAYAARAEGRT 722
Cdd:cd20484     81 EDISSLKESEIIAYLREkAKEPFVLE-NGPLM-RVHlfsRSEQEHFVLITIHHIIFDGSSSLTLIHSLLDAYQALLQGKQ 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  723 GGLPVLDVQYADYALWQQSVLGDADDEtsvlgEQLSHWRRVLAG-LPaVTDLPMDRPRPAVLGTAGATVTVEFDDDLADR 801
Cdd:cd20484    159 PTLASSPASYYDFVAWEQDMLAGAEGE-----EHRAYWKQQLSGtLP-ILELPADRPRSSAPSFEGQTYTRRLPSELSNQ 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  802 VDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTT 881
Cdd:cd20484    233 IKSFARSQSINLSTVFLGIFKLLLHRYTGQEDIIVGMPTMGRPEERFDSLIGYFINMLPIRSRILGEETFSDFIRKLQLT 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  882 VLDAFANDQVQFDELIEALAPERSSSHQPLAQIAFTYTEptvndvaGLEASGIQ--AAP---------VDTGVVNAKFDL 950
Cdd:cd20484    313 VLDGLDHAAYPFPAMVRDLNIPRSQANSPVFQVAFFYQN-------FLQSTSLQqfLAEyqdvlsiefVEGIHQEGEYEL 385

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616  951 TVAVRARSGGtpMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd20484    386 VLEVYEQEDR--FTLNIKYNPDLFDASTIERMMEHYVKLAEELIAN 429

23DHB-AMP_lg

cd05920

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...

2564-3059

8.85e-46

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.

Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 174.05 E-value: 8.85e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAY 2643
Cdd:cd05920     14 DEPLGDLLARSAARHPDRIAVVDG-DRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVP 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2644 VPIDPDYPAERVASMIEDSGAVLglsvLASGDlpgqefEWMRLDDDSVAAEIAAVPAGPitdaerlgevtaanlAYVIYT 2723
Cdd:cd05920     93 VLALPSHRRSELSAFCAHAEAVA----YIVPD------RHAGFDHRALARELAESIPEV---------------ALFLLS 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2724 SGSTGRPKGVAVTHSGLANFARQ--ESDRLNAGD-----NPVVLGF--ASPsfdaSVLEYLLA--TVnegTLAYRPSEav 2792
Cdd:cd05920    148 GGTTGTPKLIPRTHNDYAYNVRAsaEVCGLDQDTvylavLPAAHNFplACP----GVLGTLLAggRV---VLAPDPSP-- 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2793 gGEVLErFIAEHGATHTFLTPSVLS------TMDPTAVPSLRVIAAGGEAVPQPIVDRWAPA--TELHNLYGPTETTIGI 2864
Cdd:cd05920    219 -DAAFP-LIEREGVTVTALVPALVSlwldaaASRRADLSSLRLLQVGGARLSPALARRVPPVlgCTLQQVFGMAEGLLNY 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2865 TissamRPGDPVRL-----GGPIGGVD-LMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqr 2938
Cdd:cd05920    297 T-----RLDDPDEViihtqGRPMSPDDeIRVVDEEGNPVPPGEEGELLTRGPYTIRGYYRAPEHNARAFTPDGF------ 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2939 mYRTGDVVRWTPDtdtGGLTLEytGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSV-ATALAAYIVPVDGA 3017
Cdd:cd05920    366 -YRTGDLVRRTPD---GYLVVE--GRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVVAMPDELlGERSCAFVVLRDPP 439

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 1827387616 3018 VEVSELKAFAGGR-LPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05920    440 PSAAQLRRFLRERgLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482

FACL_like_6

cd05922

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

8-468

1.02e-45

Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 173.40 E-value: 1.02e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    8 RRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGH----FVPLDEQLPVDRARYMVRTAGVRLVVVtsdgE 83
Cdd:cd05922      1 LGVSAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGRlglvFVPLNPTLKESVLRYLVADAGGRIVLA----D 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDivdvhVLDISSPGDADLDEEEFAGPTRPANA--------AFTLFTSGSTGRPKAVVITHRGIANRLAADIE 155
Cdd:cd05922     77 AGAADRLRD-----ALPASPDPGTVLDADGIRAARASAPAhevshedlALLLYTSGSTGSPKLVRLSHQNLLANARSIAE 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  156 QYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRHGDPVhlADLIRRHGVTVIHFVP---AMLAAfnevLGA 232
Cdd:cd05922    152 YLGITADDRALTVLPLSYDYGLSVLNTHLLRGATLVLTNDGVLDDAF--WEDLREHGATGLAGVPstyAMLTR----LGF 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  233 GVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTI---HRVtqDDRVIPIGTPTRRVSARVLDAA 309
Cdd:cd05922    226 DPAKLPSLRYLTQAGGRLPQETIARLRELLPGAQVYVMYGQTEATRRMTYlppERI--LEKPGSIGLAIPGGEFEILDDD 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  310 LREVPIGVPGELYLGGVQLARGYAGRPDLTAERfvadpfGEPGARLYrTGDRARWNRDGEIEYLGRTDFQVKLRGQRLEL 389
Cdd:cd05922    304 GTPTPPGEPGEIVHRGPNVMKGYWNDPPYRRKE------GRGGGVLH-TGDLARRDEDGFLFIVGRRDRMIKLFGNRISP 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  390 GEVEAALAAAPGVLHAAAAVVDGPGGQQLVGY-LAPADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05922    377 TEIEAAARSIGLIIEAAAVGLPDPLGEKLALFvTAPDKIDPKDVLRSLAERLPPYKVPATVRVVDELPLTASGKVDYAAL 456

MACS_like_3

cd05971

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1060-1530

1.80e-45

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.

Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 172.23 E-value: 1.80e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1060 TEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT 1139
Cdd:cd05971      5 EKVTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALVT 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DAStrarlgesscewvdladleaeaesgDDitdterngsvrltnLAYLIYTSGSTGRPKA------VGVSHTGIVDFVNS 1213
Cdd:cd05971     85 DGS-------------------------DD--------------PALIIYTSGTTGPPKGalhahrVLLGHLPGVQFPFN 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1214 LAkittgtpedepdtrilhvasPSFDASMFEMA-WA---------IPA---GHTLVIAPQADFAGDALATVLERDEVTDM 1280
Cdd:cd05971    126 LF--------------------PRDGDLYWTPAdWAwigglldvlLPSlyfGVPVLAHRMTKFDPKAALDLMSRYGVTTA 185

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1281 IITPSVL---ATVDPERAQYVRNL---ATGGEACPPELVErWSER--GRRIFNCYGPTEAT-VWATRSRMTAGKPVTIGK 1351
Cdd:cd05971    186 FLPPTALkmmRQQGEQLKHAQVKLraiATGGESLGEELLG-WAREqfGVEVNEFYGQTECNlVIGNCSALFPIKPGSMGK 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1352 PVDGFTVRVLDGRLHEVPQGVVGELYLST--AGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAG 1429
Cdd:cd05971    265 PIPGHRVAIVDDNGTPLPPGEVGEIAVELpdPVAFLGYWNNPSATEKKMAGDWL--------LTGDLGRKDSDGYFWYVG 336

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1430 RADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV-ESTRGgrkhTEVVAYLVAKPGATiDSAAVLDEAAQH----LAA 1504
Cdd:cd05971    337 RDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIpDPIRG----EIVKAFVVLNPGET-PSDALAREIQELvktrLAA 411

                          490       500
                   ....*....|....*....|....*.
gi 1827387616 1505 HMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05971    412 HEYPREIEFVNELPRTATGKIRRREL 437

PRK06187

long-chain-fatty-acid--CoA ligase; Validated

4-471

4.69e-45

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 173.06 E-value: 4.69e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAE--VAVgiqIDR-SVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK06187    35 AELDERVNRLANALRALGVKKGdrVAV---FDWnSHEYLEAYFAVPKIGAVLHPINIRLKPEEIAYILNDAEDRVVLVDS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVDV-HVLDISSPGDADLDEE--EF------AGPTRPA------NAAFTLFTSGSTGRPKAVVITHRG 145
Cdd:PRK06187   112 EFVPLLAAILPQLPTVrTVIVEGDGPAAPLAPEvgEYeellaaASDTFDFpdidenDAAAMLYTSGTTGHPKGVVLSHRN 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  146 I-ANRLAAdIEQYDLTARDVFLYKAPI----TFDVSVreifLPIAIGATLVIaePGRHgDPVHLADLIRRHGVTVIHFVP 220
Cdd:PRK06187   192 LfLHSLAV-CAWLKLSRDDVYLVIVPMfhvhAWGLPY----LALMAGAKQVI--PRRF-DPENLLDLIETERVTFFFAVP 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  221 AMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTI-----HRVTQDDRVIPIG 295
Cdd:PRK06187   264 TIWQMLLKAPRAYFVDFSSLRLVIYGGAALPPALLREFKEKF-GIDLVQGYGMTETSPVVSVlppedQLPGQWTKRRSAG 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  296 TPTRRVSARVLDAALREVP--IGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYL 373
Cdd:PRK06187   343 RPLPGVEARIVDDDGDELPpdGGEVGEIIVRGPWLMQGYWNRPEATAETIDGG--------WLHTGDVGYIDEDGYLYIT 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  374 GRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVV---DGPGGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPS 447
Cdd:PRK06187   415 DRIKDVIISGGENIYPRELEDALYGHPAV--AEVAVIgvpDEKWGERPVAVVVLkpgATLDAKELRAFLRGRLAKFKLPK 492

                          490       500
                   ....*....|....*....|....
gi 1827387616  448 AWVRLDAMPLSRSGKVDRRLLPEP 471
Cdd:PRK06187   493 RIAFVDELPRTSVGKILKRVLREQ 516

PRK08316

acyl-CoA synthetase; Validated

1038-1525

7.71e-45

acyl-CoA synthetase; Validated

Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 172.42 E-value: 7.71e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVL---AQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYV 1114
Cdd:PRK08316    12 TIGDILrrsARRY--PDKTALVFGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAVHV 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1115 PVDPAYPADRIAYMLEDSGATVGITDASTRAR----LGESSCEWVDLADLEAEAESGDDITD----------TERNGSVR 1180
Cdd:PRK08316    90 PVNFMLTGEELAYILDHSGARAFLVDPALAPTaeaaLALLPVDTLILSLVLGGREAPGGWLDfadwaeagsvAEPDVELA 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1181 LTNLAYLIYTSGSTGRPKAVGVSHTGIV-DFVNSlakITTGtpEDEPDTRILHvASPSFD-ASM--FEMAWaIPAGHTLV 1256
Cdd:PRK08316   170 DDDLAQILYTSGTESLPKGAMLTHRALIaEYVSC---IVAG--DMSADDIPLH-ALPLYHcAQLdvFLGPY-LYVGATNV 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1257 IAPQADfAGDALATVlERDEVTDMIITPSV---------LATVD---PERAQYvrnlatGGEACPPELVERWSER--GRR 1322
Cdd:PRK08316   243 ILDAPD-PELILRTI-EAERITSFFAPPTVwisllrhpdFDTRDlssLRKGYY------GASIMPVEVLKELRERlpGLR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1323 IFNCYGPTEATVWAT--RSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVA 1400
Cdd:PRK08316   315 FYNCYGQTEIAPLATvlGPEEHLRRPGSAGRPVLNVETRVVDDDGNDVAPGEVGEIVHRSPQLMLGYWDDPEKTAEAFRG 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1401 DPFgepgarmyATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAY 1480
Cdd:PRK08316   395 GWF--------HSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPDPKWIEA---VTAV 463

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 1481 LVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKL 1525
Cdd:PRK08316   464 VVPKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKI 508

FACL_fum10p_like

cd05926

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...

1050-1532

8.31e-45

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.

Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 171.73 E-value: 8.31e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMD--YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:cd05926      1 PDAPALVVPGSTPAltYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDASTRARLGES-SCEWVDLADLEAEAESGDDITDTER-------------NGSVRLTNLAYLIYTSGS 1193
Cdd:cd05926     81 YLADLGSKLVLTPKGELGPASRAaSKLGLAILELALDVGVLIRAPSAESlsnlladkknaksEGVPLPDDLALILHTSGT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1194 TGRPKAVGVSHTGIVdfvNSLAKITTG---TPEDepdtRIL------HV-----------AS-------PSFDASMF--E 1244
Cdd:cd05926    161 TGRPKGVPLTHRNLA---ASATNITNTyklTPDD----RTLvvmplfHVhglvasllstlAAggsvvlpPRFSASTFwpD 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1245 MA-----W--AIPAGHTLVIAPQADFAGDALATVlerdevtdmiitpsvlatvdperaQYVRnlaTGGEACPPELVERWS 1317
Cdd:cd05926    234 VRdynatWytAVPTIHQILLNRPEPNPESPPPKL------------------------RFIR---SCSASLPPAVLEALE 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1318 ER-GRRIFNCYGPTEATVWATRSRMTAG--KPVTIGKPVdGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQT 1394
Cdd:cd05926    287 ATfGAPVLEAYGMTEAAHQMTSNPLPPGprKPGSVGKPV-GVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEAN 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1395 AVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRadhqVK--IN--GQRVELGEIEAVLDAQPGVAQSVVVGVESTRG 1470
Cdd:cd05926    366 AEAAFKDGW-------FRTGDLGYLDADGYLFLTGR----IKelINrgGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKY 434

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 1471 GRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:cd05926    435 GE---EVAAAVVLREGASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

2109-2353

9.84e-45

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 163.29 E-value: 9.84e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2109 MTPLQQGLFFqadlantvaDHDAIDVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVrLPSGAAVTVVPAEVTV 2188
Cdd:COG4908      1 LSPAQKRFLF---------LEPGSNAYNIPAVLRLEGPLDVEALERALRELVRRHPALRTRFV-EEDGEPVQRIDPDADL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2189 PWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHG-DGAELVVTNHHLLIDGWSSPLVLADLLSLYA- 2266
Cdd:COG4908     71 PLEVVDLSALPEPEREAELEELVAEEASRPFDLARGPLLRAALIRLGeDEHVLLLTIHHIISDGWSLGILLRELAALYAa 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2267 --TGQTFTGSLPGTSGRDFADHARAVA-TADVEAGIAAWREVLAPVTEPTLVAPGHEPSADAPPR--DHQFSIDVKVTER 2341
Cdd:COG4908    151 llEGEPPPLPELPIQYADYAAWQRAWLqSEALEKQLEYWRQQLAGAPPVLELPTDRPRPAVQTFRgaTLSFTLPAELTEA 230

                          250
                   ....*....|..
gi 1827387616 2342 LEALARNNSTTM 2353
Cdd:COG4908    231 LKALAKAHGATV 242

MCS

cd05941

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...

1051-1530

1.44e-44

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.

Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 169.39 E-value: 1.44e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1051 DHPALICDGTEMDYDEFETRTNAIARALLARGVS-PEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd05941      1 DRIAIVDDGDSITYADLVARAARLANRLLALGKDlRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVgitdastrarlgessceWVDLAdleaeaesgdditdterngsvrltnlaYLIYTSGSTGRPKAVGVSHTGIVD 1209
Cdd:cd05941     81 TDSEPSL-----------------VLDPA---------------------------LILYTSGTTGRPKGVVLTHANLAA 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1210 FVNSLAKITTGTPEDepdtRILHVAsPSFDAS--MFEMAWAIPAGHTLVIAPQADFAGDALAtvLERDEVT--------- 1278
Cdd:cd05941    117 NVRALVDAWRWTEDD----VLLHVL-PLHHVHglVNALLCPLFAGASVEFLPKFDPKEVAIS--RLMPSITvfmgvptiy 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1279 -------DMIITPSVLATVDPERAqyVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEaTVWATRSRMTAG-KPVTI 1349
Cdd:cd05941    190 trllqyyEAHFTDPQFARAAAAER--LRLMVSGSAALPVPTLEEWEAItGHTLLERYGMTE-IGMALSNPLDGErRPGTV 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1350 GKPVDGFTVRVLD-GRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFA 1428
Cdd:cd05941    267 GMPLPGVQARIVDeETGEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGW-------FKTGDLGVVDEDGYYWIL 339

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1429 GR-ADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGA-TIDSAAVLDEAAQHLAAHM 1506
Cdd:cd05941    340 GRsSVDIIKSGGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGER---VVAVVVLRAGAaALSLEELKEWAKQRLAPYK 416

                          490       500
                   ....*....|....*....|....
gi 1827387616 1507 VPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05941    417 RPRRLILVDELPRNAMGKVNKKEL 440

LC_FACS_like

cd05935

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...

1061-1530

1.65e-44

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.

Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 168.81 E-value: 1.65e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITD 1140
Cdd:cd05935      1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1141 AStrarlgesscewvdladleaeaesgdditdterngsvrLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTG 1220
Cdd:cd05935     81 SE--------------------------------------LDDLALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTGL 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1221 TPEDepdtrILHVASPSFDASMFE--MAWAIPAGHTLVIapQADFAGDALATVLERDEVTDMIITPSVLATV--DPERAQ 1296
Cdd:cd05935    123 TPSD-----VILACLPLFHVTGFVgsLNTAVYVGGTYVL--MARWDRETALELIEKYKVTFWTNIPTMLVDLlaTPEFKT 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1297 ----YVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGR-LHEVPQ 1370
Cdd:cd05935    196 rdlsSLKVLTGGGAPMPPAVAEKLLKLtGLRFVEGYGLTETMSQTHTNPPLRPKLQCLGIP*FGVDARVIDIEtGRELPP 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1371 GVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgePGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAV 1450
Cdd:cd05935    276 NEVGEIVVRGPQIFKGYWNRPEETEESFIEI----KGRRFFRTGDLGYMDEEGYFFFVDRVKRMINVSGFKVWPAEVEAK 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1451 LDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPG--ATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRA 1528
Cdd:cd05935    352 LYKHPAI*EVCVISVPDERVGE---EVKAFIVLRPEyrGKVTEEDIIEWAREQMAAYKYPREVEFVDELPRSASGKILWR 428


                   ..
gi 1827387616 1529 AL 1530
Cdd:cd05935    429 LL 430

FACL_fum10p_like

cd05926

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...

2584-3061

1.89e-44

Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 170.57 E-value: 1.89e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2584 VVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSG 2663
Cdd:cd05926      7 VVPGSTPALTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEFYLADLG 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2664 AVLglsVLASGDLPG------QEFEWMRLD---DDSV------AAEIAAVPAGPiTDAERLGEVTAANLAYVIYTSGSTG 2728
Cdd:cd05926     87 SKL---VLTPKGELGpasraaSKLGLAILElalDVGVlirapsAESLSNLLADK-KNAKSEGVPLPDDLALILHTSGTTG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2729 RPKGVAVTHSGLANFAR--QESDRLNAGDNPVVLgfaSPSFD-----ASVLEYLLAtvnegtlayrpseavGGEVL--ER 2799
Cdd:cd05926    163 RPKGVPLTHRNLAASATniTNTYKLTPDDRTLVV---MPLFHvhglvASLLSTLAA---------------GGSVVlpPR 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2800 F--------IAEHGAT--------HTFLtpsvLSTMDPTAV---PSLRVIAAGGEAVPQPIVDRW-----APATELhnlY 2855
Cdd:cd05926    225 FsastfwpdVRDYNATwytavptiHQIL----LNRPEPNPEsppPKLRFIRSCSASLPPAVLEALeatfgAPVLEA---Y 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2856 GPTETTIGITisSAMRPGDPVRLG--GPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYg 2933
Cdd:cd05926    298 GMTEAAHQMT--SNPLPPGPRKPGsvGKPVGVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANAEAAFKDGW- 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2934 tagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GGSVAtala 3008
Cdd:cd05926    375 ------FRTGDLGYLDAD---GYLFL--TGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVpdekyGEEVA---- 439

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 3009 AYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:cd05926    440 AAVVLREGAsVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493

FACL_DitJ_like

cd05934

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2589-3060

4.87e-44

Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 167.47 E-value: 4.87e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2589 GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLgl 2668
Cdd:cd05934      1 GRRWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQL-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2669 svlasgdlpgqefewmrldddsvaaeiaavpagPITDaerlgevtaanLAYVIYTSGSTGRPKGVAVTHSGLANFARQES 2748
Cdd:cd05934     79 ---------------------------------VVVD-----------PASILYTSGTTGPPKGVVITHANLTFAGYYSA 114

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2749 DRLNAGDNPVVLGFAsPSF--DASVLEYLLATVNEGTLAyrpseavggeVLERF--------IAEHGATHTFLTPSVLST 2818
Cdd:cd05934    115 RRFGLGEDDVYLTVL-PLFhiNAQAVSVLAALSVGATLV----------LLPRFsasrfwsdVRRYGATVTNYLGAMLSY 183

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2819 -------MDPTAVPsLRViAAGGEAVPQ---PIVDRWapATELHNLYGPTETTIGITissamRPGDPVRLGGPIG----G 2884
Cdd:cd05934    184 llaqppsPDDRAHR-LRA-AYGAPNPPElheEFEERF--GVRLLEGYGMTETIVGVI-----GPRDEPRRPGSIGrpapG 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2885 VDLMVLDERLRPVPVGMPGELYV---AGGALSRGYLDRSGLTAERFtanPYGtagqrMYRTGDVVRWTPDTDtggltLEY 2961
Cdd:cd05934    255 YEVRIVDDDGQELPAGEPGELVIrglRGWGFFKGYYNMPEATAEAM---RNG-----WFHTGDLGYRDADGF-----FYF 321

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2962 TGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVA-TALAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSS 3039
Cdd:cd05934    322 VDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGeDEVKAVVVLRPGEtLDPEELFAFCEGQLAYFKVPRY 401

                          490       500
                   ....*....|....*....|.
gi 1827387616 3040 FTVIDELPLTPVGKLDKRALP 3060
Cdd:cd05934    402 IRFVDDLPKTPTEKVAKAQLR 422

PRK08316

acyl-CoA synthetase; Validated

2566-3059

2.29e-43

acyl-CoA synthetase; Validated

Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 168.19 E-value: 2.29e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK08316    12 TIGDILRRSARRYPDKTALVFG-DRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAVHVP 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGAVL--------GLSVLASGDLPGQEFEWM-----RLDDDSVAAEIAAVPAGPITDAERlgEV 2712
Cdd:PRK08316    91 VNFMLTGEELAYILDHSGARAflvdpalaPTAEAALALLPVDTLILSlvlggREAPGGWLDFADWAEAGSVAEPDV--EL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2713 TAANLAYVIYTSGSTGRPKGVAVTHSGL-ANFARQESD-RLNAGDNPVV---LgFASPSFDASVLEYLL--ATvneGTLA 2785
Cdd:PRK08316   169 ADDDLAQILYTSGTESLPKGAMLTHRALiAEYVSCIVAgDMSADDIPLHalpL-YHCAQLDVFLGPYLYvgAT---NVIL 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2786 YRPSeavGGEVLERfIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYG 2856
Cdd:PRK08316   245 DAPD---PELILRT-IEAERITSFFAPPTVWISLlrhpdfDTRDLSSLRKGYYGASIMPVEVLKELRerlPGLRFYNCYG 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2857 PTEttIGiTISSAMRPGDPVRLGG----PIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpy 2932
Cdd:PRK08316   321 QTE--IA-PLATVLGPEEHLRRPGsagrPVLNVETRVVDDDGNDVAPGEVGEIVHRSPQLMLGYWDDPEKTAEAFRGG-- 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2933 gtagqrMYRTGDVVRWtpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSV-ATALAAYI 3011
Cdd:PRK08316   396 ------WFHSGDLGVM----DEEGY-ITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPDPKwIEAVTAVV 464

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1827387616 3012 VPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK08316   465 VPKAGAtVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKREL 513

FACL_like_6

cd05922

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2599-3059

3.92e-43

Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 165.69 E-value: 3.92e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2599 EASDRLAR-WLIGRGVGPERAVALAIGRSaqllTAIW---AVAKTGGA----YVPIDPDYPAERVASMIEDSGAVLGLSV 2670
Cdd:cd05922      1 LGVSAAASaLLEAGGVRGERVVLILPNRF----TYIElsfAVAYAGGRlglvFVPLNPTLKESVLRYLVADAGGRIVLAD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2671 LASGDlpgqefewmRLDDDSVAAEIAAVPAG--PITDAERLG---EVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR 2745
Cdd:cd05922     77 AGAAD---------RLRDALPASPDPGTVLDadGIRAARASApahEVSHEDLALLLYTSGSTGSPKLVRLSHQNLLANAR 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2746 QESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFiAEHGATHTFLTPSVLS-----TMD 2820
Cdd:cd05922    148 SIAEYLGITADDRALTVLPLSYDYGLSVLNTHLLRGATLVLTNDGVLDDAFWEDL-REHGATGLAGVPSTYAmltrlGFD 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2821 PTAVPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTIGITISSAMRPGD-PVRLGGPIGGVDLMVLDERLRP 2896
Cdd:cd05922    227 PAKLPSLRYLTQAGGRLPQETIARLRellPGAQVYVMYGQTEATRRMTYLPPERILEkPGSIGLAIPGGEFEILDDDGTP 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2897 VPVGMPGELYVAGGALSRGYLDRSGLTAErftanpyGTAGQRMYRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRI 2976
Cdd:cd05922    307 TPPGEPGEIVHRGPNVMKGYWNDPPYRRK-------EGRGGGVLHTGDLARRDEDGF-----LFIVGRRDRMIKLFGNRI 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2977 ELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGaVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd05922    375 SPTEIEAAARSIGLIIEAAAVGLPDPLGEKLALFVTAPDK-IDPKDVLRSLAERLPPYKVPATVRVVDELPLTASGKVDY 453


                   ...
gi 1827387616 3057 RAL 3059
Cdd:cd05922    454 AAL 456

BCL_4HBCL

cd05959

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...

2569-3059

5.06e-43

Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 166.78 E-value: 5.06e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDP 2648
Cdd:cd05959      8 LVDLNLNEGRGDKTAFIDDAG-SLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNT 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2649 DYPAERVASMIEDSGAVLglsVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPITDAERLGEVTAA------------- 2715
Cdd:cd05959     87 LLTPDDYAYYLEDSRARV---VVVSGELAPVLAAALTKSEHTLVVLIVSGGAGPEAGALLLAELVAAeaeqlkpaathad 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLA----NFARqesDRLNAGDNPVVLGfASPSFDASVL--EYLLATVNEGTLAYRPS 2789
Cdd:cd05959    164 DPAFWLYSSGSTGRPKGVVHLHADIYwtaeLYAR---NVLGIREDDVCFS-AAKLFFAYGLgnSLTFPLSVGATTVLMPE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2790 EAVGGEVLERfIAEHGATHTFLTPSVLSTMdpTAVP--------SLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETT 2861
Cdd:cd05959    240 RPTPAAVFKR-IRRYRPTVFFGVPTLYAAM--LAAPnlpsrdlsSLRLCVSAGEALPAEVGERWKARFGLDILDGIGSTE 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2862 IG-ITISSamRPGDpVRLGG---PIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagq 2937
Cdd:cd05959    317 MLhIFLSN--RPGR-VRYGTtgkPVPGYEVELRDEDGGDVADGEPGELYVRGPSSATMYWNNRDKTRDTFQGE------- 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2938 rMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVA-TALAAYIVPVDG 3016
Cdd:cd05959    387 -WTRTGDKYVRDDDG-----FYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDGlTKPKAFVVLRPG 460

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616 3017 ----AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05959    461 yedsEALEEELKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKL 507

A_NRPS_alphaAR

cd17647

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ...

2579-3062

6.41e-43

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as alpha-aminoadipate reductase (EC 1.2.1.95) or alpha-AR or L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), which catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 166.54 E-value: 6.41e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2579 PDHVAVV------DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPA 2652
Cdd:cd17647      2 PERTCVVetpslnSSKTRSFTYRDINEASNIVAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2653 ERvasmiedsgAVLGLSVLASGDLpgqefewmrldddsVAAEIAAVPAGPITDAErlgevtaanlayVIYTSGSTGRPKG 2732
Cdd:cd17647     82 AR---------QNIYLGVAKPRGL--------------IVIRAAGVVVGPDSNPT------------LSFTSGSEGIPKG 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2733 VAVTHSGLANFARQESDRLNAGDN---PVVLGFASPSFDASVLEYLLAtvneGTLAYRPSEAVGG--EVLERFIAEHGAT 2807
Cdd:cd17647    127 VLGRHFSLAYYFPWMAKRFNLSENdkfTMLSGIAHDPIQRDMFTPLFL----GAQLLVPTQDDIGtpGRLAEWMAKYGAT 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2808 HTFLTPS---VLSTMDPTAVPSLRVIAAGGEAVPQPIVDRW---APATELHNLYGPTETTIGIT---ISSamRPGDPVRL 2878
Cdd:cd17647    203 VTHLTPAmgqLLTAQATTPFPKLHHAFFVGDILTKRDCLRLqtlAENVRIVNMYGTTETQRAVSyfeVPS--RSSDPTFL 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2879 ---------GGPIGGVDLMVLD--ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQ---------- 2937
Cdd:cd17647    281 knlkdvmpaGRGMLNVQLLVVNrnDRTQICGIGEVGEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEPDHwnyldkdnne 360

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2938 -----------RMYRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAV-ESAVVLGVGGSVAT 3005
Cdd:cd17647    361 pwrqfwlgprdRLYRTGDLGRYLPNGD-----CECCGRADDQVKIRGFRIELGEIDTHISQHPLVrENITLVRRDKDEEP 435

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3006 ALAAYIVPVDGAVE----------------------------VSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKR 3057
Cdd:cd17647    436 TLVSYIVPRFDKPDdesfaqedvpkevstdpivkgligyrklIKDIREFLKKRLASYAIPSLIVVLDKLPLNPNGKVDKP 515


                   ....*
gi 1827387616 3058 ALPEP 3062
Cdd:cd17647    516 KLQFP 520

CHC_CoA_lg

cd05903

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...

1064-1525

1.05e-42

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.

Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 163.71 E-value: 1.05e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAST 1143
Cdd:cd05903      4 YSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVVPERF 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 RARlgesscewvdladleAEAESGDDItdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPE 1223
Cdd:cd05903     84 RQF---------------DPAAMPDAV--------------ALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGLGPG 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1224 DepdtRILhVASP--SFDASMFEMAWAIPAGHTLVIapQADFAGDALATVLERDEVTDMIITP----SVLATVD--PERA 1295
Cdd:cd05903    135 D----VFL-VASPmaHQTGFVYGFTLPLLLGAPVVL--QDIWDPDKALALMREHGVTFMMGATpfltDLLNAVEeaGEPL 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1296 QYVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEatVWATRSRMTAGKP----VTIGKPVDGFTVRVLDGRLHEVPQ 1370
Cdd:cd05903    208 SRLRTFVCGGATVPRSLARRAAELlGAKVCSAYGSTE--CPGAVTSITPAPEdrrlYTDGRPLPGVEIKVVDDTGATLAP 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1371 GVVGELYLSTAGLARGYLGRPGQTAvsfVADPFGepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAV 1450
Cdd:cd05903    286 GVEGELLSRGPSVFLGYLDRPDLTA---DAAPEG-----WFRTGDLARLDEDGYLRITGRSKDIIIRGGENIPVLEVEDL 357

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1451 LDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAV---LDeaAQHLAAHMVPSQAIVIDEIPLTPAGKL 1525
Cdd:cd05903    358 LLGHPGVIEAAVVALPDERLGER---ACAVVVTKSGALLTFDELvayLD--RQGVAKQYWPERLVHVDDLPRTPSGKV 430

MACS_like_4

cd05969

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...

1064-1530

1.40e-42

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.

Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 163.83 E-value: 1.40e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAST 1143
Cdd:cd05969      3 FAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLITTEEL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 RARlgesscewvdladleaeaesgddiTDTErngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPE 1223
Cdd:cd05969     83 YER------------------------TDPE--------DPTLLHYTSGTTGTPKGVLHVHDAMIFYYFTGKYVLDLHPD 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1224 DepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSVL-----ATVDPERA--- 1295
Cdd:cd05969    131 D----IYWCTADPGWVTGTVYGIWAPWLNGVTNVVYEGRFDAESWYGIIERVKVTVWYTAPTAIrmlmkEGDELARKydl 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1296 QYVRNLATGGEACPPELVeRWSER--GRRIFNCYGPTEatvwaTRSRMTAG------KPVTIGKPVDGFTVRVLDGRLHE 1367
Cdd:cd05969    207 SSLRFIHSVGEPLNPEAI-RWGMEvfGVPIHDTWWQTE-----TGSIMIANypcmpiKPGSMGKPLPGVKAAVVDENGNE 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1368 VPQGVVGELYLSTA--GLARGYLGRPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELG 1445
Cdd:cd05969    281 LPPGTKGILALKPGwpSMFRGIWNDEERYKNSFIDG--------WYLTGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPF 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1446 EIEAVLDAQPGVAQSVVVGVES-TRGGRkhteVVAYLVAKPGATIDSA---AVLDEAAQHLAAHMVPSQAIVIDEIPLTP 1521
Cdd:cd05969    353 EVESALMEHPAVAEAGVIGKPDpLRGEI----IKAFISLKEGFEPSDElkeEIINFVRQKLGAHVAPREIEFVDNLPKTR 428


                   ....*....
gi 1827387616 1522 AGKLDRAAL 1530
Cdd:cd05969    429 SGKIMRRVL 437

LCL_NRPS-like

cd19531

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar ...

2108-2535

2.81e-42

Pssm-ID: 380454 [Multi-domain] Cd Length: 427 Bit Score: 162.14 E-value: 2.81e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQGLFF--QADLANTVadhdaidvYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVrLPSGAAVTVVPAE 2185
Cdd:cd19531      3 PLSFAQQRLWFldQLEPGSAA--------YNIPGALRLRGPLDVAALERALNELVARHEALRTTFV-EVDGEPVQVILPP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2186 VTVPWSVIDLRAEDAASLDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDgAE--LVVTNHHLLIDGWSSPLVLADLLS 2263
Cdd:cd19531     74 LPLPLPVVDLSGLPEAEREAEAQRLAREEARRPFDLARGPLLRATLLRLGE-DEhvLLLTMHHIVSDGWSMGVLLRELAA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2264 LYATGQTFTGS----LPgtsgRDFADHA---RAVATADV-EAGIAAWREVLA---PVTE-PTlvapghepsaDAPPRDHQ 2331
Cdd:cd19531    153 LYAAFLAGRPSplppLP----IQYADYAvwqREWLQGEVlERQLAYWREQLAgapPVLElPT----------DRPRPAVQ 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2332 --------FSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRS-PDIEGmesMVGMFINTIP 2402
Cdd:cd19531    219 sfrgarvrFTLPAELTAALRALARREGATLFMTLLAAFQVLLHRYSGQDDIVVGTPVAGRNrAELEG---LIGFFVNTLV 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2403 AVVDVNPDATVVDVLTAVQNDKVKVLDHQQigLP--RLVAQTGLP------ALFDTLAVYESFPVNVDSVAGIDASSAGg 2474
Cdd:cd19531    296 LRTDLSGDPTFRELLARVRETALEAYAHQD--LPfeKLVEALQPErdlsrsPLFQVMFVLQNAPAAALELPGLTVEPLE- 372

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 2475 lklVGAKTSdatHYPLNLSASRRGAELALKLKYlPTA-FAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19531    373 ---VDSGTA---KFDLTLSLTETDGGLRGSLEY-NTDlFDAATIERMAGHFQTLLEAIVADP 427

Firefly_Luc_like

cd05911

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...

2583-3054

3.47e-42

Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 163.54 E-value: 3.47e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2583 AVVDGA-GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIED 2661
Cdd:cd05911      1 AQIDADtGKELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2662 SGA-------------------------VLGLSVLASGDLPGQEfewmrLDDDSVAAEIAAVPAGPITDAERlgevtaan 2716
Cdd:cd05911     81 SKPkviftdpdglekvkeaakelgpkdkIIVLDDKPDGVLSIED-----LLSPTLGEEDEDLPPPLKDGKDD-------- 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2717 LAYVIYTSGSTGRPKGVAVTHSGL-ANFAR-QESDRLNAGDNPVVLGFaSPSFDAS-VLEYLLATVNEGTLA--YRPSEa 2791
Cdd:cd05911    148 TAAILYSSGTTGLPKGVCLSHRNLiANLSQvQTFLYGNDGSNDVILGF-LPLYHIYgLFTTLASLLNGATVIimPKFDS- 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 vggEVLERFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTI 2862
Cdd:cd05911    226 ---ELFLDLIEKYKITFLYLVPPIAAALakspllDKYDLSSLRVILSGGAPLSKELQELLAkrfPNATIKQGYGMTETGG 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2863 GITISsamrPGDPVRL---GGPIGGVDLMVLDERLRP-VPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqr 2938
Cdd:cd05911    303 ILTVN----PDGDDKPgsvGRLLPNVEAKIVDDDGKDsLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGW------ 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2939 mYRTGDVVRWtpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATAL-AAYIVPVDGA 3017
Cdd:cd05911    373 -LHTGDIGYF----DEDGY-LYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELpRAYVVRKPGE 446

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 3018 VEVS-ELKAFAGGRLPAY------MVpssftVIDELPLTPVGKL 3054
Cdd:cd05911    447 KLTEkEVKDYVAKKVASYkqlrggVV-----FVDEIPKSASGKI 485

PRK07798

acyl-CoA synthetase; Validated

1037-1526

5.27e-42

acyl-CoA synthetase; Validated

Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 164.29 E-value: 5.27e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1037 GTLIDVLAqrDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPV 1116
Cdd:PRK07798     6 ADLFEAVA--DAVPDRVALVCGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1117 DPAYPADRIAYMLEDSGATVGITDASTRARLGESScewVDLADLEAEAESGDDITDTERNGSVRLTNLA----------- 1185
Cdd:PRK07798    84 NYRYVEDELRYLLDDSDAVALVYEREFAPRVAEVL---PRLPKLRTLVVVEDGSGNDLLPGAVDYEDALaagsperdfge 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1186 ------YLIYTSGSTGRPKAV-------------GVSHtGIVDFVNSLAKITTGTPEDEPDTRIlhVASPSFDASMFEMA 1246
Cdd:PRK07798   161 rspddlYLLYTGGTTGMPKGVmwrqedifrvllgGRDF-ATGEPIEDEEELAKRAAAGPGMRRF--PAPPLMHGAGQWAA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1247 W-AIPAGHTLVIAPQADFAGDALATVLERDEVTDMIIT------PSVLATVDPERAQY--VRNLATGGEACPPELVERWS 1317
Cdd:PRK07798   238 FaALFSGQTVVLLPDVRFDADEVWRTIEREKVNVITIVgdamarPLLDALEARGPYDLssLFAIASGGALFSPSVKEALL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1318 ER--GRRIFNCYGPTEA-----TVWATRSRMTAGKPVTIGKpvdgfTVRVLDGRLHEVPQGVVGELYLSTAG-LARGYLG 1389
Cdd:PRK07798   318 ELlpNVVLTDSIGSSETgfggsGTVAKGAVHTGGPRFTIGP-----RTVVLDEDGNPVEPGSGEIGWIARRGhIPLGYYK 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1390 RPGQTAVSF-VADpfgepGARMYATGDLVRVAKGGNLEFAGRADhqVKIN--GQRVELGEIEAVLDAQPGVAQSVVVGVE 1466
Cdd:PRK07798   393 DPEKTAETFpTID-----GVRYAIPGDRARVEADGTITLLGRGS--VCINtgGEKVFPEEVEEALKAHPDVADALVVGVP 465

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1467 STRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:PRK07798   466 DERWGQ---EVVAVVQLREGARPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGKAD 522

CBAL

cd05923

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...

2566-3059

6.43e-42

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.

Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 163.06 E-value: 6.43e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAGA-RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:cd05923      2 TVFEMLRRAASRAPDACAIADPARGlRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVPA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDS---GAVLGLSVLASGDLPGQEFEWMRLDDDsVAAEIAAVPAGPITDAERLGEVTaanlAYVI 2721
Cdd:cd05923     82 LINPRLKAAELAELIERGemtAAVIAVDAQVMDAIFQSGVRVLALSDL-VGLGEPESAGPLIEDPPREPEQP----AFVF 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2722 YTSGSTGRPKGVAVTH----SGLANFARQESDRLnaGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVL 2797
Cdd:cd05923    157 YTSGTTGLPKGAVIPQraaeSRVLFMSTQAGLRH--GRHNVVLGLMPLYHVIGFFAVLVAALALDGTYVVVEEFDPADAL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2798 ErFIAEHGATHTFLTPSVL------STMDPTAVPSLRVIAAGGEAVPQPIVDRWAPA--TELHNLYGPTETTIGI----- 2864
Cdd:cd05923    235 K-LIEQERVTSLFATPTHLdalaaaAEFAGLKLSSLRHVTFAGATMPDAVLERVNQHlpGEKVNIYGTTEAMNSLymrda 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2865 TISSAMRPG--DPVRLgGPIGGVDLMVLderlrpvPVGMPGELYVAGGALS--RGYLDRSGLTAERFTanpygtagQRMY 2940
Cdd:cd05923    314 RTGTEMRPGffSEVRI-VRIGGSPDEAL-------ANGEEGELIVAAAADAafTGYLNQPEATAKKLQ--------DGWY 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2941 RTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GGSVatalAAYIVPVD 3015
Cdd:cd05923    378 RTGDVGYVDPSGD-----VRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIGVaderwGQSV----TACVVPRE 448

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 3016 GAVEVSELKAFA-GGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05923    449 GTLSADELDQFCrASELADFKRPRRYFFLDELPKNAMNKVLRRQL 493

23DHB-AMP_lg

cd05920

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...

1-468

2.50e-41

Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 160.96 E-value: 2.50e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVpldEQLPVDRAR---YMVRTAGVRLVV 77
Cdd:cd05920     41 LTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVPV---LALPSHRRSelsAFCAHAEAVAYI 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   78 VtsdgeAEARSRFDDIVDVHVLDISSPgdadldeeefagptrpaNAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQY 157
Cdd:cd05920    118 V-----PDRHAGFDHRALARELAESIP-----------------EVALFLLSGGTTGTPKLIPRTHNDYAYNVRASAEVC 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  158 DLTARDVFLYKAPI--TFDVSVREIFLPIAIGATLVIAEPGrhgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVG 235
Cdd:cd05920    176 GLDQDTVYLAVLPAahNFPLACPGVLGTLLAGGRVVLAPDP---SPDAAFPLIEREGVTVTALVPALVSLWLDAAASRRA 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  236 ELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTihRVTQDDRVIpIGTPTRRVSA----RVLDAALR 311
Cdd:cd05920    253 DLSSLRLLQVGGARLSPALARRVPPVL-GCTLQQVFGMAEGLLNYT--RLDDPDEVI-IHTQGRPMSPddeiRVVDEEGN 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  312 EVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGE 391
Cdd:cd05920    329 PVPPGEEGELLTRGPYTIRGYYRAPEHNARAFTPDGF-------YRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEE 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  392 VEAALAAAPGVLHAAAAVVDGPG-GQQLVGYLAPADVDVDTV---AATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRL 467
Cdd:cd05920    402 VENLLLRHPAVHDAAVVAMPDELlGERSCAFVVLRDPPPSAAqlrRFLRERGLAAYKLPDRIEFVDSLPLTAVGKIDKKA 481


                   .
gi 1827387616  468 L 468
Cdd:cd05920    482 L 482

FACL_DitJ_like

cd05934

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2-469

5.36e-41

Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 158.61 E-value: 5.36e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVtsd 81
Cdd:cd05934      5 TYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVVV--- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 geaearsrfdDIVDVhvldisspgdadldeeefagptrpanaaftLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTA 161
Cdd:cd05934     82 ----------DPASI------------------------------LYTSGTTGPPKGVVITHANLTFAGYYSARRFGLGE 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  162 RDVFLYKAPItF--DVSVREIFLPIAIGATLVIAE---PGRhgdpvhLADLIRRHGVTVIHFVPAMLAAfneVLGAGVGE 236
Cdd:cd05934    122 DDVYLTVLPL-FhiNAQAVSVLAALSVGATLVLLPrfsASR------FWSDVRRYGATVTNYLGAMLSY---LLAQPPSP 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 LTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEAsIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIG 316
Cdd:cd05934    192 DDRAHRLRAAYGAPNPPELHEEFEERFGVRLLEGYGMTET-IVGVIGPRDEPRRPGSIGRPAPGYEVRIVDDDGQELPAG 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  317 VPGELYLGGVQ---LARGYAGRPDLTAERFvadpfgEPGarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVE 393
Cdd:cd05934    271 EPGELVIRGLRgwgFFKGYYNMPEATAEAM------RNG--WFHTGDLGYRDADGFFYFVDRKKDMIRRRGENISSAEVE 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  394 AALAAAPGVLHAAA-AVVDGPGGQQLVGYLA---PADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:cd05934    343 RAILRHPAVREAAVvAVPDEVGEDEVKAVVVlrpGETLDPEELFAFCEGQLAYFKVPRYIRFVDDLPKTPTEKVAKAQLR 422

CT_NRPS-like

cd19542

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

571-996

6.87e-41

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 157.47 E-value: 6.87e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  571 LPLSRAQRRMwfLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVY-PSVGAAP-VQDVLpvavAREQ 648
Cdd:cd19542      2 YPCTPMQEGM--LLSQLRSPGLYFNHFVFDLDSSVDVERLRNAWRQLVQRHDILRTVFvESSAEGTfLQVVL----KSLD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  649 LDWREADSVE-SLVRSTTEGFDVST---QMPLRGRFHRDGAGLH-VALTMHHIAMDGQSIPVLARDLMSAYAARAEGRTg 723
Cdd:cd19542     76 PPIEEVETDEdSLDALTRDLLDDPTlfgQPPHRLTLLETSSGEVyLVLRISHALYDGVSLPIILRDLAAAYNGQLLPPA- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  724 glpvldVQYADYA--LWQQSVLgdaddetsvlgEQLSHWRRVLAGLPAVTDlpmdrprPAVLGTAGATVTVEFDDDLADR 801
Cdd:cd19542    155 ------PPFSDYIsyLQSQSQE-----------ESLQYWRKYLQGASPCAF-------PSLSPKRPAERSLSSTRRSLAK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  802 VDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRN--DPALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVR 879
Cdd:cd19542    211 LEAFCASLGVTLASLFQAAWALVLARYTGSRDVVFGYVVSGRDlpVPGIDDIVGPCINTLPVRVKLDPDWTVLDLLRQLQ 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  880 TTVLDAFANDQVQFDELIEALapeRSSSHQPLAQIAFTYteptVNDVAGLEASGIQAAPVDTGVVNAKFDLTVAVRARSG 959
Cdd:cd19542    291 QQYLRSLPHQHLSLREIQRAL---GLWPSGTLFNTLVSY----QNFEASPESELSGSSVFELSAAEDPTEYPVAVEVEPS 363

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1827387616  960 GTPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19542    364 GDSLKVSLAYSTSVLSEEQAEELLEQFDDILEALLAN 400

menE

TIGR01923

O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ...

1064-1530

7.23e-41

O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]

Pssm-ID: 162605 [Multi-domain] Cd Length: 436 Bit Score: 158.38 E-value: 7.23e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASt 1143
Cdd:TIGR01923    2 WQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLEDLDVQLLLTDSL- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 rarLGESSCEWVDLADLEAEAESgdditDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPE 1223
Cdd:TIGR01923   81 ---LEEKDFQADSLDRIEAAGRY-----ETSLSASFNMDQIATLMFTSGTTGKPKAVPHTFRNHYASAVGSKENLGFTED 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1224 DepdtRILhVASPSFDASMFEMAW-AIPAGHTLVIaPQADfagDALATVLERDEVTDMIITPSVLATVDPERA--QYVRN 1300
Cdd:TIGR01923  153 D----NWL-LSLPLYHISGLSILFrWLIEGATLRI-VDKF---NQLLEMIANERVTHISLVPTQLNRLLDEGGhnENLRK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1301 LATGGEACPPELVERWSERGRRIFNCYGPTEA--TVWATRSRMTAGKPvTIGKPVDGFTVRVldgrlhEVP-QGVVGELY 1377
Cdd:TIGR01923  224 ILLGGSAIPAPLIEEAQQYGLPIYLSYGMTETcsQVTTATPEMLHARP-DVGRPLAGREIKI------KVDnKEGHGEIM 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1378 LSTAGLARGYLGR-PGQTAvsfvadpFGEPGarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPG 1456
Cdd:TIGR01923  297 VKGANLMKGYLYQgELTPA-------FEQQG--WFNTGDIGELDGEGFLYVLGRRDDLIISGGENIYPEEIETVLYQHPG 367

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 1457 VAQSVVVGVE-STRGGRKhtevVAYLVAKpgATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:TIGR01923  368 IQEAVVVPKPdAEWGQVP----VAYIVSE--SDISQAKLIAYLTEKLAKYKVPIAFEKLDELPYNASGKILRNQL 436

PRK13391

acyl-CoA synthetase; Provisional

2575-3059

1.98e-40

acyl-CoA synthetase; Provisional

Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 159.09 E-value: 1.98e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVV-DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAE 2653
Cdd:PRK13391     7 AQTTPDKPAVImASTGEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2654 RVASMIEDSG--------AVLGLSVLASGDLPGQEfEWMRLDDD-------SVAAEIAAVPAGPITDaERLGevtaanlA 2718
Cdd:PRK13391    87 EAAYIVDDSGaralitsaAKLDVARALLKQCPGVR-HRLVLDGDgelegfvGYAEAVAGLPATPIAD-ESLG-------T 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2719 YVIYTSGSTGRPKGV--------AVTHSGLANFA------RQESDRLNagdnPVVLGFASPSFDASVLEYLLATVnegtl 2784
Cdd:PRK13391   158 DMLYSSGTTGRPKGIkrplpeqpPDTPLPLTAFLqrlwgfRSDMVYLS----PAPLYHSAPQRAVMLVIRLGGTV----- 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2785 ayrpseavggEVLERF--------IAEHGATHTFLTPSVLSTM--------DPTAVPSLRVIAAGGEAVPQPI----VDR 2844
Cdd:PRK13391   229 ----------IVMEHFdaeqylalIEEYGVTHTQLVPTMFSRMlklpeevrDKYDLSSLEVAIHAAAPCPPQVkeqmIDW 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2845 WAPAteLHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGvDLMVLDERLRPVPVGMPGELYVAGGaLSRGYLDRSGLTA 2924
Cdd:PRK13391   299 WGPI--IHEYYAATEGLGFTACDSEEWLAHPGTVGRAMFG-DLHILDDDGAELPPGEPGTIWFEGG-RPFEYLNDPAKTA 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2925 ErfTANPYGTagqrMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-GGSV 3003
Cdd:PRK13391   375 E--ARHPDGT----WSTVGDIGY----VDEDGY-LYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVpNEDL 443

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3004 ATALAAYIVPVDGAVE----VSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK13391   444 GEEVKAVVQPVDGVDPgpalAAELIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLL 503

PRK07514

malonyl-CoA synthase; Validated

1039-1535

2.69e-40

malonyl-CoA synthase; Validated

Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 158.50 E-value: 2.69e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1039 LIDVLAQRDLDPDHPAL-ICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVD 1117
Cdd:PRK07514     5 LFDALRAAFADRDAPFIeTPDGLRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGAVFLPLN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1118 PAYPADRIAYMLEDSGATVGITDASTR-------ARLGESSCEWVDlAD-----LEAEAESGDDITDTERNGSvrltNLA 1185
Cdd:PRK07514    85 TAYTLAELDYFIGDAEPALVVCDPANFawlskiaAAAGAPHVETLD-ADgtgslLEAAAAAPDDFETVPRGAD----DLA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1186 YLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHvaspsfdasmfemawAIPAGHT--LVIAPQ-AD 1262
Cdd:PRK07514   160 AILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWRFTPDD----VLIH---------------ALPIFHThgLFVATNvAL 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1263 FAGDAL--ATVLERDEVTDMIITPSVLATV-------------DPERAQYVRnLATGGEAcpPELVE---RWSER-GRRI 1323
Cdd:PRK07514   221 LAGASMifLPKFDPDAVLALMPRATVMMGVptfytrllqeprlTREAAAHMR-LFISGSA--PLLAEthrEFQERtGHAI 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNCYGPTEaTVWATrSRMTAGK--PVTIGKPVDGFTVRVLD---GRlhEVPQGVVGELYLSTAGLARGYLGRPGQTAVSF 1398
Cdd:PRK07514   298 LERYGMTE-TNMNT-SNPYDGErrAGTVGFPLPGVSLRVTDpetGA--ELPPGEIGMIEVKGPNVFKGYWRMPEKTAEEF 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1399 VADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVestrggrKHTE-- 1476
Cdd:PRK07514   374 RADGF-------FITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGV-------PHPDfg 439

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1477 --VVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHA 1535
Cdd:PRK07514   440 egVTAVVVPKPGAALDEAAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLREQYA 500

BCL_like

cd05919

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...

2592-3059

2.91e-40

Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 156.85 E-value: 2.91e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAvlglsvl 2671
Cdd:cd05919     11 VTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDCEA------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrldddsvaaeiaavpagpitdaeRLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR---QES 2748
Cdd:cd05919     84 ------------------------------------RLVVTSADDIAYLLYSSGTTGPPKGVMHAHRDPLLFADamaREA 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2749 DRLNAGDnpVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLSTM------DPT 2822
Cdd:cd05919    128 LGLTPGD--RVFSSAKMFFGYGLGNSLWFPLAVGASAVLNPGWPTAERVLATLARFRPTVLYGVPTFYANLldscagSPD 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2823 AVPSLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETTIGITISSAmRPGD--PVRLGGPIGGVDLMVLDERLRPVPVG 2900
Cdd:cd05919    206 ALRSLRLCVSAGEALPRGLGERWMEHFGGPILDGIGATEVGHIFLSN-RPGAwrLGSTGRPVPGYEIRLVDEEGHTIPPG 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2901 MPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRWTPDtdtGGLTleYTGRSDDQVKLRGLRIELGE 2980
Cdd:cd05919    285 EEGDLLVRGPSAAVGYWNNPEKSRATFNGG--------WYRTGDKFCRDAD---GWYT--HAGRADDMLKVGGQWVSPVE 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2981 IEAVLAEHDAVESAVVLGV-GGSVATALAAYIVPVDGAVE----VSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLD 3055
Cdd:cd05919    352 VESLIIQHPAVAEAAVVAVpESTGLSRLTAFVVLKSPAAPqeslARDIHRHLLERLSAHKVPRRIAFVDELPRTATGKLQ 431


                   ....
gi 1827387616 3056 KRAL 3059
Cdd:cd05919    432 RFKL 435

PRK07788

acyl-CoA synthetase; Validated

1021-1532

5.05e-40

acyl-CoA synthetase; Validated

Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 158.55 E-value: 5.05e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1021 ARTPGAMVGRGgevEAGTLIDVLAQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSV 1100
Cdd:PRK07788    39 LRLAADIRRYG---PFAGLVAHAARRA--PDRAALIDERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFV 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1101 LATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCE------WVDLADLEAEAESG----DDI 1170
Cdd:PRK07788   114 LALYAAGKVGARIILLNTGFSGPQLAEVAAREGVKALVYDDEFTDLLSALPPDlgrlraWGGNPDDDEPSGSTdetlDDL 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1171 TDTERNGSVRL--TNLAYLIYTSGSTGRPKAVGVSHTGIVDfvnSLAKITTGTPEDEPDTRILhvASPSFDA---SMFEM 1245
Cdd:PRK07788   194 IAGSSTAPLPKppKPGGIVILTSGTTGTPKGAPRPEPSPLA---PLAGLLSRVPFRAGETTLL--PAPMFHAtgwAHLTL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1246 AWAIpaGHTLVIapQADFagDALATV--LERDEVTDMIITPSVLA---TVDPE-RAQY----VRNLATGGEACPPELVER 1315
Cdd:PRK07788   269 AMAL--GSTVVL--RRRF--DPEATLedIAKHKATALVVVPVMLSrilDLGPEvLAKYdtssLKIIFVSGSALSPELATR 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1316 WSER-GRRIFNCYGPTEATvWATRSRMT--AGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPG 1392
Cdd:PRK07788   343 ALEAfGPVLYNLYGSTEVA-FATIATPEdlAEAPGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGFPFEGYTDGRD 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1393 QTAVSfvadpfgepgaRMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGR 1472
Cdd:PRK07788   422 KQIID-----------GLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDEEFGQ 490

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1473 KhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK07788   491 R---LRAFVVKAPGAALDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547

MCS

cd05941

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...

2580-3059

5.15e-40

Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 155.91 E-value: 5.15e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2580 DHVAVVDGaGARLTYRELDEASDRLARWLIGRG-VGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASM 2658
Cdd:cd05941      1 DRIAIVDD-GDSITYADLVARAARLANRLLALGkDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2659 IEDSGAVLGLsvlasgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevtaaNLAYVIYTSGSTGRPKGVAVTHS 2738
Cdd:cd05941     80 ITDSEPSLVL-----------------------------------------------DPALILYTSGTTGRPKGVVLTHA 112

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2739 GLANFAR--------QESDR--------------------LNAGDNPVVLGFASPSFDASVLEYLLATVNEGTlayrPSe 2790
Cdd:cd05941    113 NLAANVRalvdawrwTEDDVllhvlplhhvhglvnallcpLFAGASVEFLPKFDPKEVAISRLMPSITVFMGV----PT- 187

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2791 avggeVLERFIAEHGATHTFLTPSVLSTMDPtavpsLRVIAAGGEAVPQPIVDRWAPATElHNL---YGPTEttIGITIS 2867
Cdd:cd05941    188 -----IYTRLLQYYEAHFTDPQFARAAAAER-----LRLMVSGSAALPVPTLEEWEAITG-HTLlerYGMTE--IGMALS 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2868 SamrPGDPVRLGGPIG----GVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRT 2942
Cdd:cd05941    255 N---PLDGERRPGTVGmplpGVQARIVDeETGEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGW-------FKT 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2943 GDVVRWTPDtdtGGLTLeyTGR-SDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GGSVatalAAYIVPVDG 3016
Cdd:cd05941    325 GDLGVVDED---GYYWI--LGRsSVDIIKSGGYKVSALEIERVLLAHPGVSECAVIGVpdpdwGERV----VAVVVLRAG 395

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 3017 AVEVS--ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05941    396 AAALSleELKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKEL 440

PRK06188

acyl-CoA synthetase; Validated

2560-3059

6.85e-40

acyl-CoA synthetase; Validated

Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 157.84 E-value: 6.85e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2560 PATDPVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKT 2639
Cdd:PRK06188     7 LLHSGATYGHLLVSALKRYPDRPALVLG-DTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPEVLMAIGAAQLA 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2640 GGAYVPIDPDYPAERVASMIEDSGA--------------------VLGLS-VLASGDLPGQEfewmrldddSVAAEIAAV 2698
Cdd:PRK06188    86 GLRRTALHPLGSLDDHAYVLEDAGIstlivdpapfveralallarVPSLKhVLTLGPVPDGV---------DLLAAAAKF 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2699 PAGPITDAERLGEVtaanlAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLgFASPSFDASVLEYLLAT 2778
Cdd:PRK06188   157 GPAPLVAAALPPDI-----AGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWEWPADPRFL-MCTPLSHAGGAFFLPTL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2779 VNEGTLAYRPSEAVGgEVLeRFIAEHGATHTFLTPSVL-STMD-----PTAVPSLRVIAAGGEAVpQPivDRWAPATE-- 2850
Cdd:PRK06188   231 LRGGTVIVLAKFDPA-EVL-RAIEEQRITATFLVPTMIyALLDhpdlrTRDLSSLETVYYGASPM-SP--VRLAEAIErf 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2851 ---LHNLYGPTETTIGITIssaMR-----PGDPVRL---GGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDR 2919
Cdd:PRK06188   306 gpiFAQYYGQTEAPMVITY---LRkrdhdPDDPKRLtscGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWNR 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2920 SGLTAERFtANPYgtagqrmYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV 2999
Cdd:PRK06188   383 PEETAEAF-RDGW-------LHTGDVAR----EDEDGF-YYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGV 449

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 3000 -----GGSVatalAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK06188   450 pdekwGEAV----TAVVVLRPGAaVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKAL 511

PRK07656

long-chain-fatty-acid--CoA ligase; Validated

1-470

7.38e-40

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 157.37 E-value: 7.38e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK07656    31 LTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVVPLNTRYTADEAAYILARGDAKALFVLG 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVDV-HVLDISSPGDADL--------------DEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRG 145
Cdd:PRK07656   111 LFLGVDYSATTRLPALeHVVICETEEDDPHtekmktftdflaagDPAERAPEVDPDDVADILFTSGTTGRPKGAMLTHRQ 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  146 IAnRLAADIEQY-DLTARD----------VFLYKAPITfdvsvreifLPIAIGATLVIAepgRHGDPVHLADLIRRHGVT 214
Cdd:PRK07656   191 LL-SNAADWAEYlGLTEGDrylaanpffhVFGYKAGVN---------APLMRGATILPL---PVFDPDEVFRLIETERIT 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  215 VIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIP- 293
Cdd:PRK07656   258 VLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAASMPVALLERFESELGVDIVLTGYGLSEASGVTTFNRLDDDRKTVAg 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  294 -IGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarLYrTGDRARWNRDGeieY 372
Cdd:PRK07656   338 tIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDDPEATAAAIDADGW------LH-TGDLGRLDEEG---Y 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  373 LGRTD----------FQVKLRgqrlelgEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGYLAP---ADVDVDTVAATT 436
Cdd:PRK07656   408 LYIVDrkkdmfivggFNVYPA-------EVEEVLYEHPAV--AEAAVIGVPDerlGEVGKAYVVLkpgAELTEEELIAYC 478

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1827387616  437 AELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK07656   479 REHLAKYKVPRSIEFLDELPKNATGKVLKRALRE 512

MACS_like

cd05972

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...

1064-1530

1.38e-39

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.

Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 154.42 E-value: 1.38e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASt 1143
Cdd:cd05972      3 FRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDAE- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 rarlgesscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVDFvnslaKITTGTPE 1223
Cdd:cd05972     82 ---------------------------------------DPALIYFTSGTTGLPKGVLHTHSYPLGH-----IPTAAYWL 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1224 D-EPDTRILHVASPS---FDASMFEMAWAipAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSV---LATVDPERAQ 1296
Cdd:cd05972    118 GlRPDDIHWNIADPGwakGAWSSFFGPWL--LGATVFVYEGPRFDAERILELLERYGVTSFCGPPTAyrmLIKQDLSSYK 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1297 Y--VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVV 1373
Cdd:cd05972    196 FshLRLVVSAGEPLNPEVIEWWRAAtGLPIRDGYGQTETGLTVGNFPDMPVKPGSMGRPTPGYDVAIIDDDGRELPPGEE 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1374 GEL--YLSTAGLARGYLGRPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVL 1451
Cdd:cd05972    276 GDIaiKLPPPGLFLGYVGDPEKTEASIRGD--------YYLTGDRAYRDEDGYFWFVGRADDIIKSSGYRIGPFEVESAL 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1452 DAQPGVAQSVVVGV-ESTRGgrkhtEVV-AYLVAKPGATiDSAAVLDEAAQH----LAAHMVPSQAIVIDEIPLTPAGKL 1525
Cdd:cd05972    348 LEHPAVAEAAVVGSpDPVRG-----EVVkAFVVLTSGYE-PSEELAEELQGHvkkvLAPYKYPREIEFVEELPKTISGKI 421


                   ....*
gi 1827387616 1526 DRAAL 1530
Cdd:cd05972    422 RRVEL 426

EntE

COG1021

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...

1-468

1.98e-39

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 156.46 E-value: 1.98e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGghFVPLDeQLPVDRA---RYMVRTAGVRLVV 77
Cdd:COG1021     51 LSYAELDRRADRLAAGLLALGLRPGDRVVVQLPNVAEFVIVFFALFRAG--AIPVF-ALPAHRRaeiSHFAEQSEAVAYI 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   78 VtsdgeAEARSRFDD---IVDV--------HVLDISSPGD----ADLDEEEFAGP---TRPANAAFTLFTSGSTGRPKAV 139
Cdd:COG1021    128 I-----PDRHRGFDYralARELqaevpslrHVLVVGDAGEftslDALLAAPADLSeprPDPDDVAFFQLSGGTTGLPKLI 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  140 VITHRGIAN--RLAADIeqYDLTARDVFLYKAPI--TFDVSVREIFLPIAIGATLVIAEpgrHGDPVHLADLIRRHGVTV 215
Cdd:COG1021    203 PRTHDDYLYsvRASAEI--CGLDADTVYLAALPAahNFPLSSPGVLGVLYAGGTVVLAP---DPSPDTAFPLIERERVTV 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  216 IHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTihRVTQDDRVIpIG 295
Cdd:COG1021    278 TALVPPLALLWLDAAERSRYDLSSLRVLQVGGAKLSPELARRVRPAL-GCTLQQVFGMAEGLVNYT--RLDDPEEVI-LT 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  296 TPTRRVSA----RVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIE 371
Cdd:COG1021    354 TQGRPISPddevRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRAPEHNARAFTPDGF-------YRTGDLVRRTPDGYLV 426

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  372 YLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDgpggqQLVGYLAPADVDVDTVAATTAEL--------LPE 442
Cdd:COG1021    427 VEGRAKDQINRGGEKIAAEEVENLLLAHPAVHDAAVvAMPD-----EYLGERSCAFVVPRGEPLTLAELrrflrergLAA 501

                          490       500
                   ....*....|....*....|....*.
gi 1827387616  443 YMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:COG1021    502 FKLPDRLEFVDALPLTAVGKIDKKAL 527

CHC_CoA_lg

cd05903

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...

2591-3056

2.60e-39

Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 153.69 E-value: 2.60e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2591 RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAvlglSV 2670
Cdd:cd05903      1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKA----KV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2671 LASGDlpgqefEWMRLDddsvaaeIAAVPAGPitdaerlgevtaanlAYVIYTSGSTGRPKGVAVTHSGLANFARQESDR 2750
Cdd:cd05903     77 FVVPE------RFRQFD-------PAAMPDAV---------------ALLLFTSGTTGEPKGVMHSHNTLSASIRQYAER 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2751 LNAGDNPVVLGfASP--SFDASVLEYLLATVnEGTLA-----YRPSEAVggevleRFIAEHGATHTFLTPSVLSTM---- 2819
Cdd:cd05903    129 LGLGPGDVFLV-ASPmaHQTGFVYGFTLPLL-LGAPVvlqdiWDPDKAL------ALMREHGVTFMMGATPFLTDLlnav 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2820 --DPTAVPSLRVIAAGGEAVPQPIVDRWAPA--TELHNLYGPTETTigiTISSAMRPGDPVRL----GGPIGGVDLMVLD 2891
Cdd:cd05903    201 eeAGEPLSRLRTFVCGGATVPRSLARRAAELlgAKVCSAYGSTECP---GAVTSITPAPEDRRlytdGRPLPGVEIKVVD 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2892 ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTanpygtagQRMYRTGDVVRWtpdTDTGGLTLeyTGRSDDQVKL 2971
Cdd:cd05903    278 DTGATLAPGVEGELLSRGPSVFLGYLDRPDLTADAAP--------EGWFRTGDLARL---DEDGYLRI--TGRSKDIIIR 344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2972 RGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYIVPVDGA-VEVSELKA-FAGGRLPAYMVPSSFTVIDELPL 3048
Cdd:cd05903    345 GGENIPVLEVEDLLLGHPGVIEAAVVALPDErLGERACAVVVTKSGAlLTFDELVAyLDRQGVAKQYWPERLVHVDDLPR 424


                   ....*...
gi 1827387616 3049 TPVGKLDK 3056
Cdd:cd05903    425 TPSGKVQK 432

SgcC5_NRPS-like

cd19539

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

2140-2533

2.66e-39

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 153.69 E-value: 2.66e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2140 VLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAEVTVPWSVIDLRAEDAAsLDSRVEEVLATERTNPF 2219
Cdd:cd19539     29 AWRLTGPLDVEALREALRDVVARHEALRTLLVRDDGGVPRQEILPPGPAPLEVRDLSDPDSD-RERRLEELLRERESRGF 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2220 DMAKPPLIRVVLVEHG-DGAELVVTNHHLLIDGWSSPLVLADLLSLYATGQTFTGS-LPGTSG--RDFADHARAVATAD- 2294
Cdd:cd19539    108 DLDEEPPIRAVLGRFDpDDHVLVLVAHHTAFDAWSLDVFARDLAALYAARRKGPAApLPELRQqyKEYAAWQREALAAPr 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2295 VEAGIAAWREVLAPVTEPTLVAPGHEPS-ADAPPRDHQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRT 2373
Cdd:cd19539    188 AAELLDFWRRRLRGAEPTALPTDRPRPAgFPYPGADLRFELDAELVAALRELAKRARSSLFMVLLAAYCVLLRRYTGQTD 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2374 VTFAETVSGRSPDieGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQ------TGLPAL 2447
Cdd:cd19539    268 IVVGTPVAGRNHP--RFESTVGFFVNLLPLRVDVSDCATFRDLIARVRKALVDAQRHQELPFQQLVAElpvdrdAGRHPL 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2448 FDTLAVYESFPVNVDSVAGidassaGGLKLVGAKTSDATHYPLNLSASRRGAELALKLKYLPTAFAPEQVAVF-ADVLTG 2526
Cdd:cd19539    346 VQIVFQVTNAPAGELELAG------GLSYTEGSDIPDGAKFDLNLTVTEEGTGLRGSLGYATSLFDEETIQGFlADYLQV 419


                   ....*..
gi 1827387616 2527 LLGAIAD 2533
Cdd:cd19539    420 LRQLLAN 426

MACS_like_3

cd05971

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

2586-3059

5.04e-39

Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 152.97 E-value: 5.04e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2586 DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAv 2665
Cdd:cd05971      1 KGTPEKVTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGA- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2666 lglSVLasgdlpgqefewmrldddsvaaeiaavpagpITDAerlgevtAANLAYVIYTSGSTGRPKGVAVTHSGLA---- 2741
Cdd:cd05971     80 ---SAL-------------------------------VTDG-------SDDPALIIYTSGTTGPPKGALHAHRVLLghlp 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2742 ------NFARQESDrlnagdnpVVLGFASPSFDASVLEYLLATVNEGT--LAYRPSEAVGGEVLErFIAEHGATHTFLTP 2813
Cdd:cd05971    119 gvqfpfNLFPRDGD--------LYWTPADWAWIGGLLDVLLPSLYFGVpvLAHRMTKFDPKAALD-LMSRYGVTTAFLPP 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2814 SVLSTM-------DPTAVpSLRVIAAGGEAVPQPIVdRWAPAT---ELHNLYGPTETTIGITISSAMRPGDPVRLGGPIG 2883
Cdd:cd05971    190 TALKMMrqqgeqlKHAQV-KLRAIATGGESLGEELL-GWAREQfgvEVNEFYGQTECNLVIGNCSALFPIKPGSMGKPIP 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2884 GVDLMVLDERLRPVPVGMPGELyvaggALSR-------GYLDRSGLTAERFtANPYgtagqrmYRTGDVVRwtpdTDTGG 2956
Cdd:cd05971    268 GHRVAIVDDNGTPLPPGEVGEI-----AVELpdpvaflGYWNNPSATEKKM-AGDW-------LLTGDLGR----KDSDG 330

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2957 LtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVAT-ALAAYIVPVDGAVE----VSELKAFAGGRL 3031
Cdd:cd05971    331 Y-FWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGeIVKAFVVLNPGETPsdalAREIQELVKTRL 409

                          490       500
                   ....*....|....*....|....*...
gi 1827387616 3032 PAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05971    410 AAHEYPREIEFVNELPRTATGKIRRREL 437

A_NRPS_alphaAR

cd17647

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ...

13-471

7.89e-39

Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 154.60 E-value: 7.89e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   13 LARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGeaearsrfdd 92
Cdd:cd17647     33 VAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPPARQNIYLGVAKPRGLIVIRAA---------- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   93 ivDVHVLDISSPgdadldeeefagptrpanaafTL-FTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPI 171
Cdd:cd17647    103 --GVVVGPDSNP---------------------TLsFTSGSEGIPKGVLGRHFSLAYYFPWMAKRFNLSENDKFTMLSGI 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  172 TFDVSVREIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMlaafNEVLGAGVGE-LTSLRLIQTGGEAL 250
Cdd:cd17647    160 AHDPIQRDMFTPLFLGAQLLVPTQDDIGTPGRLAEWMAKYGATVTHLTPAM----GQLLTAQATTpFPKLHHAFFVGDIL 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  251 TPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVT---QDDR-------VIPIGTPTRRVSARVLDAALRE--VPIGVP 318
Cdd:cd17647    236 TKRDCLRLQTLAENVRIVNMYGTTETQRAVSYFEVPsrsSDPTflknlkdVMPAGRGMLNVQLLVVNRNDRTqiCGIGEV 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GELYLGGVQLARGYAGRPDLTAERFVADPFGEPGA---------------------RLYRTGDRARWNRDGEIEYLGRTD 377
Cdd:cd17647    316 GEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEPDHwnyldkdnnepwrqfwlgprdRLYRTGDLGRYLPNGDCECCGRAD 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  378 FQVKLRGQRLELGEVEAALAAAPGVLHAAAAV-VDGPGGQQLVGYLAP----------ADVDVDTVAATTAEL------- 439
Cdd:cd17647    396 DQVKIRGFRIELGEIDTHISQHPLVRENITLVrRDKDEEPTLVSYIVPrfdkpddesfAQEDVPKEVSTDPIVkgligyr 475

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616  440 -------------LPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEP 471
Cdd:cd17647    476 klikdireflkkrLASYAIPSLIVVLDKLPLNPNGKVDKPKLQFP 520

starter-C_NRPS

cd19533

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases ...

570-996

9.04e-39

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. While standard C-domains catalyze peptide bond formation between two amino acids, an initial, ('starter') C-domain may instead acylate an amino acid with a fatty acid. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380456 [Multi-domain] Cd Length: 419 Bit Score: 151.75 E-value: 9.04e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  570 RLPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVA-VAREQ 648
Cdd:cd19533      1 RLPLTSAQRGVWFAEQLDPEGSIYNLAEYLEITGPVDLAVLERALRQVIAEAETLRLRFTEEEGEPYQWIDPYTpVPIRH 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  649 LDWREADSVESLVRSTTEGfDVSTQMPLRGRFHRDGAGLHVA-------LTMHHIAMDGQSIPVLARDLMSAYAARAEGR 721
Cdd:cd19533     81 IDLSGDPDPEGAAQQWMQE-DLRKPLPLDNDPLFRHALFTLGdnrhfwyQRVHHIVMDGFSFALFGQRVAEIYTALLKGR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  722 TGG----LPVLDV-----QYADYALWQqsvlgdaddetsvlgEQLSHWRRVLAGLPAVTDLpmdRPRPAVLGTAGATVTV 792
Cdd:cd19533    160 PAPpapfGSFLDLveeeqAYRQSERFE---------------RDRAFWTEQFEDLPEPVSL---ARRAPGRSLAFLRRTA 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  793 EFDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDPGHSVG 872
Cdd:cd19533    222 ELPPELTRTLLEAAEAHGASWPSFFIALVAAYLHRLTGANDVVLGVPVMGRLGAAARQTPGMVANTLPLRLTVDPQQTFA 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  873 DLLGNVRTTVLDAFANDQVQFDELIEALApeRSSSHQPLAQIAFTYTE-PTVNDVAGLEAsgiQAAPVDTGVVNakfDLT 951
Cdd:cd19533    302 ELVAQVSRELRSLLRHQRYRYEDLRRDLG--LTGELHPLFGPTVNYMPfDYGLDFGGVVG---LTHNLSSGPTN---DLS 373

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616  952 VAVRARSGGTPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19533    374 IFVYDRDDESGLRIDFDANPALYSGEDLARHQERLLRLLEEAAAD 418

PRK06178

acyl-CoA synthetase; Validated

2565-3066

1.26e-38

acyl-CoA synthetase; Validated

Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 154.81 E-value: 1.26e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2565 VTLAELFRAAARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:PRK06178    33 RPLTEYLRAWARERPQRPAI-IFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVHV 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSGA--VLGLSVLA------SGDLPGQEFEWMRLDD-----------DSVAA------------ 2693
Cdd:PRK06178   112 PVSPLFREHELSYELNDAGAevLLALDQLApvveqvRAETSLRHVIVTSLADvlpaeptlplpDSLRAprlaaagaidll 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2694 -EIAAVPAGPITDAERLGEVTAANlayviYTSGSTGRPKGVAVTHSGLA-NFARQESDRLNAGDNPVVLGFAsPSF---- 2767
Cdd:PRK06178   192 pALRACTAPVPLPPPALDALAALN-----YTGGTTGMPKGCEHTQRDMVyTAAAAYAVAVVGGEDSVFLSFL-PEFwiag 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2768 -DASVLEYLLATVNEGTLAYRPSEAVggevlERFIAEHGATHTFLT-PSVLSTMDPTAV-----PSLRVIAAGG--EAVP 2838
Cdd:PRK06178   266 eNFGLLFPLFSGATLVLLARWDAVAF-----MAAVERYRVTRTVMLvDNAVELMDHPRFaeydlSSLRQVRVVSfvKKLN 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2839 QPIVDRWAPATE---LHNLYGPTETTIGITISSAMRPGD------PVRLGGPIGGVDLMVLD-ERLRPVPVGMPGELYVA 2908
Cdd:PRK06178   341 PDYRQRWRALTGsvlAEAAWGMTETHTCDTFTAGFQDDDfdllsqPVFVGLPVPGTEFKICDfETGELLPLGAEGEIVVR 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2909 GGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRWTPDtdtgGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEH 2988
Cdd:PRK06178   421 TPSLLKGYWNKPEATAEALRDG--------WLHTGDIGKIDEQ----GF-LHYLGRRKEMLKVNGMSVFPSEVEALLGQH 487

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2989 DAVESAVVLGVG----GSVATalaAYIVPVDGA-VEVSELKAFAGGRLPAYMVPsSFTVIDELPLTPVGKLDKRALpEPV 3063
Cdd:PRK06178   488 PAVLGSAVVGRPdpdkGQVPV---AFVQLKPGAdLTAAALQAWCRENMAVYKVP-EIRIVDALPMTATGKVRKQDL-QAL 562


                   ...
gi 1827387616 3064 LEA 3066
Cdd:PRK06178   563 AEE 565

EntE

COG1021

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...

1038-1530

2.46e-38

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 152.99 E-value: 2.46e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAayVPV 1116
Cdd:COG1021     26 TLGDLLRRRaERHPDRIAVVDGERRLSYAELDRRADRLAAGLLALGLRPGDRVVVQLPNVAEFVIVFFALFRAGA--IPV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1117 DpAYPADR---IAYMLEDSGATVGITDASTR-------AR--------------LGESScEWVDLADLEAEAESGDDITd 1172
Cdd:COG1021    104 F-ALPAHRraeISHFAEQSEAVAYIIPDRHRgfdyralARelqaevpslrhvlvVGDAG-EFTSLDALLAAPADLSEPR- 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1173 terngsVRLTNLAYLIYTSGSTGRPKAVGVSHTgivDFVNSL---AKITTGTpedePDTRILHV---------ASPSFDA 1240
Cdd:COG1021    181 ------PDPDDVAFFQLSGGTTGLPKLIPRTHD---DYLYSVrasAEICGLD----ADTVYLAAlpaahnfplSSPGVLG 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1241 SMFemawaipAGHTLVIAPQADfAGDALATVlERDEVTDMIITPSV----LATVDPERAQY--VRNLATGGEACPPELVE 1314
Cdd:COG1021    248 VLY-------AGGTVVLAPDPS-PDTAFPLI-ERERVTVTALVPPLallwLDAAERSRYDLssLRVLQVGGAKLSPELAR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1315 RWsergRRIFNC-----YGPTEATVWATR------SRMTagkpvTIGKPV-DGFTVRVLDGRLHEVPQGVVGELYlsTAG 1382
Cdd:COG1021    319 RV----RPALGCtlqqvFGMAEGLVNYTRlddpeeVILT-----TQGRPIsPDDEVRIVDEDGNPVPPGEVGELL--TRG 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1383 --LARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQvkIN--GQRVELGEIEAVLDAQPGVA 1458
Cdd:COG1021    388 pyTIRGYYRAPEHNARAFTPDGF-------YRTGDLVRRTPDGYLVVEGRAKDQ--INrgGEKIAAEEVENLLLAHPAVH 458

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 1459 QSVVVGVESTRGGRKhteVVAYLVAKpGATIDSAAVLDE-AAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:COG1021    459 DAAVVAMPDEYLGER---SCAFVVPR-GEPLTLAELRRFlRERGLAAFKLPDRLEFVDALPLTAVGKIDKKAL 527

PRK09088

acyl-CoA synthetase; Validated

2575-3064

9.68e-38

acyl-CoA synthetase; Validated

Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 150.34 E-value: 9.68e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVVDGA-GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAE 2653
Cdd:PRK09088     5 ARLQPQRLAAVDLAlGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSAS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2654 RVASMIEDSGA--VLGLSVLASGdlpgqefewmRLDDDSVAAEIAAVPAGPITDAERLgevTAANLAYVIYTSGSTGRPK 2731
Cdd:PRK09088    85 ELDALLQDAEPrlLLGDDAVAAG----------RTDVEDLAAFIASADALEPADTPSI---PPERVSLILFTSGTSGQPK 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2732 GVAVTHSGLANFARQESdRLNAGDNPVVLGFASPSFDASVLeyllatvnegTLAYRPSEAVGGEVL----------ERFI 2801
Cdd:PRK09088   152 GVMLSERNLQQTAHNFG-VLGRVDAHSSFLCDAPMFHIIGL----------ITSVRPVLAVGGSILvsngfepkrtLGRL 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2802 AEH--GATHTFLTPSVLS------TMDPTAVPSLRVIAAGGEAVPQPIVDRW-APATELHNLYGPTE--TTIGITISSAM 2870
Cdd:PRK09088   221 GDPalGITHYFCVPQMAQafraqpGFDAAALRHLTALFTGGAPHAAEDILGWlDDGIPMVDGFGMSEagTVFGMSVDCDV 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2871 RPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTP 2950
Cdd:PRK09088   301 IRAKAGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAFTGDGW-------FRTGDIARRDA 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2951 DtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATalaAYIVPVDG-AVEVSELKA 3025
Cdd:PRK09088   374 D---GFFWV--VDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMAdaqwGEVGY---LAIVPADGaPLDLERIRS 445

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1827387616 3026 FAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVL 3064
Cdd:PRK09088   446 HLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLRDALA 484

PRK08276

long-chain-fatty-acid--CoA ligase; Validated

2582-3068

1.20e-37

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 150.44 E-value: 1.20e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2582 VAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIED 2661
Cdd:PRK08276     2 AVIMAPSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDD 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2662 SGA-VL-------------------GLSVLA--SGDLPGqefewmrldDDSVAAEIAAVPAGPITDaERLGevtaanlAY 2719
Cdd:PRK08276    82 SGAkVLivsaaladtaaelaaelpaGVPLLLvvAGPVPG---------FRSYEEALAAQPDTPIAD-ETAG-------AD 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHSGL------ANFARQESDRLNAGDNPVVLGfASPSFDASVLEYLLAtvnegtlayrpSEAVG 2793
Cdd:PRK08276   145 MLYSSGTTGRPKGIKRPLPGLdpdeapGMMLALLGFGMYGGPDSVYLS-PAPLYHTAPLRFGMS-----------ALALG 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2794 GEV--LERFIAE--------HGATHTFLTPSVLSTMD--PTAV------PSLRVIAAGGEAVPQPI----VDRWAPAteL 2851
Cdd:PRK08276   213 GTVvvMEKFDAEealalierYRVTHSQLVPTMFVRMLklPEEVrarydvSSLRVAIHAAAPCPVEVkramIDWWGPI--I 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2852 HNLYGPTETtIGITISSAM----RPGDpvrLGGPIGGVdLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAErf 2927
Cdd:PRK08276   291 HEYYASSEG-GGVTVITSEdwlaHPGS---VGKAVLGE-VRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAA-- 363

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2928 tanpyGTAGQRMYRTGDV--VrwtpDTDtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----G 3000
Cdd:PRK08276   364 -----ARNPHGWVTVGDVgyL----DED-GYLYL--TDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVpdeemG 431

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 3001 GSVAtalaAYIVPVDGA----VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGE 3068
Cdd:PRK08276   432 ERVK----AVVQPADGAdagdALAAELIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRDRYWEGRQ 499

PRK13382

bile acid CoA ligase;

2566-3062

1.47e-37

bile acid CoA ligase;

Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 151.06 E-value: 1.47e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAGArLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK13382    44 GPTSGFAIAAQRCPDRPGLIDELGT-LTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILL 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGAV--------LGLSVLASGDLPG--QEFEWMRLDDDSVAAEIAAVPAG-PITDAERLGEVta 2714
Cdd:PRK13382   123 LNTSFAGPALAEVVTREGVDtviydeefSATVDRALADCPQatRIVAWTDEDHDLTVEVLIAAHAGqRPEPTGRKGRV-- 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2715 anlayVIYTSGSTGRPKGVAVTHSGLANFARQESDRLN-AGDNPVVLgfASPSFDA-----SVLEYLLATVNEGTLAYRP 2788
Cdd:PRK13382   201 -----ILLTSGTTGTPKGARRSGPGGIGTLKAILDRTPwRAEEPTVI--VAPMFHAwgfsqLVLAASLACTIVTRRRFDP 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2789 SEAVggevleRFIAEHGATHTFLTPSVL--------STMDPTAVPSLRVIAAGGEAVPQPIV----DRWAPAteLHNLYG 2856
Cdd:PRK13382   274 EATL------DLIDRHRATGLAVVPVMFdrimdlpaEVRNRYSGRSLRFAAASGSRMRPDVViafmDQFGDV--IYNNYN 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2857 PTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYldRSGLTAERFTAnpygtag 2936
Cdd:PRK13382   346 ATEAGMIATATPADLRAAPDTAGRPAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGY--TSGSTKDFHDG------- 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2937 qrMYRTGDVVRWtpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYIVPVD 3015
Cdd:PRK13382   417 --FMASGDVGYL----DENGR-LFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVIGVDDEqYGQRLAAFVVLKP 489

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616 3016 GAVEVSE-LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEP 3062
Cdd:PRK13382   490 GASATPEtLKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQAR 537

AAS_C

cd05909

C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...

13-464

2.36e-37

C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.

Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 149.40 E-value: 2.36e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   13 LARELTALGVGAEvAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTSDgeaearsRFDD 92
Cdd:cd05909     20 LARKLAKMTKEGE-NVGVMLPPSAGGALANFALALSGKVPVMLNYTAGLRELRACIKLAGIK-TVLTSK-------QFIE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   93 IVDVHVL-DISSPGD---------------------------ADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHR 144
Cdd:cd05909     91 KLKLHHLfDVEYDARivyledlrakiskadkckaflagkfppKWLLRIFGVAPVQPDDPAVILFTSGSEGLPKGVVLSHK 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  145 GIANRLAADIEQYDLTARDVFLYKAPI--TFDVSVrEIFLPIAIGATLVIaepgrHGDPVH---LADLIRRHGVTVIHFV 219
Cdd:cd05909    171 NLLANVEQITAIFDPNPEDVVFGALPFfhSFGLTG-CLWLPLLSGIKVVF-----HPNPLDykkIPELIYDKKATILLGT 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  220 PAMLAAFneVLGAGVGELTSLRLIQTGGEALTPPVaRDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTR 299
Cdd:cd05909    245 PTFLRGY--ARAAHPEDFSSLRLVVAGAEKLKDTL-RQEFQEKFGIRILEGYGTTECSPVISVNTPQSPNKEGTVGRPLP 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  300 RVSARVLD-AALREVPIGVPGELYLGGVQLARGYAGRPDLTAErfvadpfgEPGARLYRTGDRARWNRDGEIEYLGRTDF 378
Cdd:cd05909    322 GMEVKIVSvETHEEVPIGEGGLLLVRGPNVMLGYLNEPELTSF--------AFGDGWYDTGDIGKIDGEGFLTITGRLSR 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  379 QVKLRGQRLELGEVEAALAAAPG--VLHAAAAVVDGPGGQQLVGYLAPADVDVDTV--AATTAElLPEYMRPSAWVRLDA 454
Cdd:cd05909    394 FAKIAGEMVSLEAIEDILSEILPedNEVAVVSVPDGRKGEKIVLLTTTTDTDPSSLndILKNAG-ISNLAKPSYIHQVEE 472

                          490
                   ....*....|
gi 1827387616  455 MPLSRSGKVD 464
Cdd:cd05909    473 IPLLGTGKPD 482

PRK13382

bile acid CoA ligase;

1044-1533

2.72e-37

bile acid CoA ligase;

Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 150.29 E-value: 2.72e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1044 AQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:PRK13382    53 AQRC--PDRPGLIDELGTLTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILLLNTSFAGP 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGITDASTRARLGES---------SCEWVD-----LADLEAEAESGDDITDTERNGSVrltnlayLIY 1189
Cdd:PRK13382   131 ALAEVVTREGVDTVIYDEEFSATVDRAladcpqatrIVAWTDedhdlTVEVLIAAHAGQRPEPTGRKGRV-------ILL 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1190 TSGSTGRPKavGVSHTGIVDFvNSLAKITTGTP--EDEPdtriLHVASPSFDASMF-EMAWAIPAGHTLVIapQADFAGD 1266
Cdd:PRK13382   204 TSGTTGTPK--GARRSGPGGI-GTLKAILDRTPwrAEEP----TVIVAPMFHAWGFsQLVLAASLACTIVT--RRRFDPE 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1267 ALATVLERDEVTDMIITPS----VLATVDPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWAT 1337
Cdd:PRK13382   275 ATLDLIDRHRATGLAVVPVmfdrIMDLPAEVRNRYsgrsLRFAAASGSRMRPDVVIAFMDQfGDVIYNNYNATEAGMIAT 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1338 RS-RMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYlgRPGQTAvsfvadpfgEPGARMYATGDL 1416
Cdd:PRK13382   355 ATpADLRAAPDTAGRPAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGY--TSGSTK---------DFHDGFMASGDV 423

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1417 VRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLD 1496
Cdd:PRK13382   424 GYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQR---LAAFVVLKPGASATPETLKQ 500

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1827387616 1497 EAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEP 1533
Cdd:PRK13382   501 HVRDNLANYKVPRDIVVLDELPRGATGKILRRELQAR 537

PRK06839

o-succinylbenzoate--CoA ligase;

1042-1532

3.47e-37

o-succinylbenzoate--CoA ligase;

Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 148.85 E-value: 3.47e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1042 VLAQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAY 1120
Cdd:PRK06839     8 IEKRAYLHPDRIAIITEEEEMTYKQLHEYVSKVAAYLIYElNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1121 PADRIAYMLEDSGATV-------GITDASTRARLGESSCEWV-DLADLEAEAESGDDitdtERNGSVrltnlAYLI-YTS 1191
Cdd:PRK06839    88 TENELIFQLKDSGTTVlfvektfQNMALSMQKVSYVQRVISItSLKEIEDRKIDNFV----EKNESA-----SFIIcYTS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1192 GSTGRPK-AVGVSHTGIVDFVNSLAKITTgTPEDEPDTRIlhvasPSFDASMFEMaWAIP---AGHTLVIAPQadFAGDA 1267
Cdd:PRK06839   159 GTTGKPKgAVLTQENMFWNALNNTFAIDL-TMHDRSIVLL-----PLFHIGGIGL-FAFPtlfAGGVIIVPRK--FEPTK 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1268 LATVLERDEVTDMIITPSVLATV--DPERA----QYVRNLATGGEACPPELVERWSERGRRIFNCYGPTEA--TVWATRS 1339
Cdd:PRK06839   230 ALSMIEKHKVTVVMGVPTIHQALinCSKFEttnlQSVRWFYNGGAPCPEELMREFIDRGFLFGQGFGMTETspTVFMLSE 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1340 RMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSfVADPFgepgarmYATGDLVRV 1419
Cdd:PRK06839   310 EDARRKVGSIGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEET-IQDGW-------LCTGDLARV 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1420 AKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEA 1498
Cdd:PRK06839   382 DEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWG----EIpIAFIVKKSSSVLIEKDVIEHC 457

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1827387616 1499 AQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK06839   458 RLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVN 491

MACS_like_2

cd05973

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

2592-3059

5.28e-37

Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 146.89 E-value: 5.28e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLglsvl 2671
Cdd:cd05973      1 LTFGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARL----- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrldddsvaaeiaavpagPITDAERLGEVTAANLAYvIYTSGSTGRPKGVAVTHSGLANFARQESDRL 2751
Cdd:cd05973     76 ------------------------------VVTDAANRHKLDSDPFVM-MFTSGTTGLPKGVPVPLRALAAFGAYLRDAV 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLSTM--DPTAVP---- 2825
Cdd:cd05973    125 DLRPEDSFWNAADPGWAYGLYYAITGPLALGHPTILLEGGFSVESTWRVIERLGVTNLAGSPTAYRLLmaAGAEVParpk 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2826 -SLRVIAAGGEAVpQPIVDRWAPA---TELHNLYGPTEttIGITISSAMRPGDPVR---LGGPIGGVDLMVLDERLRPVP 2898
Cdd:cd05973    205 gRLRRVSSAGEPL-TPEVIRWFDAalgVPIHDHYGQTE--LGMVLANHHALEHPVHagsAGRAMPGWRVAVLDDDGDELG 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2899 VGMPGELyvaggALSRgylDRSGLTAER-FTANPYGTAGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIE 2977
Cdd:cd05973    282 PGEPGRL-----AIDI---ANSPLMWFRgYQLPDTPAIDGGYYLTGDTVEFDPDG-----SFSFIGRADDVITMSGYRIG 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2978 LGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEVS-----ELKAFAGGRLPAYMVPSSFTVIDELPLTPVG 3052
Cdd:cd05973    349 PFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVLRGGHEGTpaladELQLHVKKRLSAHAYPRTIHFVDELPKTPSG 428


                   ....*..
gi 1827387616 3053 KLDKRAL 3059
Cdd:cd05973    429 KIQRFLL 435

4CL

cd05904

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...

1049-1527

6.14e-37

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.

Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 148.54 E-value: 6.14e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1049 DPDHPALI--CDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIA 1126
Cdd:cd05904     18 HPSRPALIdaATGRALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAEIA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1127 YMLEDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGDDITDTERNGS-----VRLTNLAYLIYTSGSTGRPKAVG 1201
Cdd:cd05904     98 KQVKDSGAKLAFTTAELAEKLASLALPVVLLDSAEFDSLSFSDLLFEADEAEppvvvIKQDDVAALLYSSGTTGRSKGVM 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1202 VSHTGivdFVNSLAKITTGT-PEDEPDTRIL------HVaspsFDASMFEMAwAIPAGHTLVIAPQADFaGDALATVlER 1274
Cdd:cd05904    178 LTHRN---LIAMVAQFVAGEgSNSDSEDVFLcvlpmfHI----YGLSSFALG-LLRLGATVVVMPRFDL-EELLAAI-ER 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1275 DEVTDMIITPSVL------ATVDPERAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWATR---SRMTA 1343
Cdd:cd05904    248 YKVTHLPVVPPIVlalvksPIVDKYDLSSLRQIMSGAAPLGKELIEAFRAKfpNVDLGQGYGMTESTGVVAMcfaPEKDR 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 GKPVTIGKPVDGFTVRVLD---GRLheVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVA 1420
Cdd:cd05904    328 AKYGSVGRLVPNVEAKIVDpetGES--LPPNQTGELWIRGPSIMKGYLNNPEATAATIDKEGW-------LHTGDLCYID 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1421 KGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEAA 1499
Cdd:cd05904    399 EDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAG----EVpMAFVVRKPGSSLTEDEIMDFVA 474

                          490       500
                   ....*....|....*....|....*...
gi 1827387616 1500 QHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd05904    475 KQVAPYKKVRKVAFVDAIPKSPSGKILR 502

PRK08276

long-chain-fatty-acid--CoA ligase; Validated

1058-1536

7.71e-37

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 148.13 E-value: 7.71e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1058 DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVG 1137
Cdd:PRK08276     8 SGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDSGAKVL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1138 ITDASTRARLGESSCE-----------------WVDLADLEAeAESGDDITDtERNGSVrltnlayLIYTSGSTGRPKAV 1200
Cdd:PRK08276    88 IVSAALADTAAELAAElpagvplllvvagpvpgFRSYEEALA-AQPDTPIAD-ETAGAD-------MLYSSGTTGRPKGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1201 --GVSHTGIVDFVNSLAKITTGTPEDEPDTRILhVASPSFDA--SMFEMaWAIPAGHTLVIAPQADfAGDALATVlERDE 1276
Cdd:PRK08276   159 krPLPGLDPDEAPGMMLALLGFGMYGGPDSVYL-SPAPLYHTapLRFGM-SALALGGTVVVMEKFD-AEEALALI-ERYR 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1277 VTDMIITPS----VLATVDPERAQY----VRNLATGGEACPPE----LVERWserGRRIFNCYGPTEA--TVWATrSRMT 1342
Cdd:PRK08276   235 VTHSQLVPTmfvrMLKLPEEVRARYdvssLRVAIHAAAPCPVEvkraMIDWW---GPIIHEYYASSEGggVTVIT-SEDW 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1343 AGKPVTIGKPVDGfTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVadpfgepGARMYATGDLVRVAKG 1422
Cdd:PRK08276   311 LAHPGSVGKAVLG-EVRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAARN-------PHGWVTVGDVGYLDED 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1423 GNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSA---AVLDEAA 1499
Cdd:PRK08276   383 GYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGE---RVKAVVQPADGADAGDAlaaELIAWLR 459

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1827387616 1500 QHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAP 1536
Cdd:PRK08276   460 GRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRDRYWE 496

BCL_4HBCL

cd05959

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...

2-468

1.10e-36

Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 147.90 E-value: 1.10e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:cd05959     31 TYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNTLLTPDDYAYYLEDSRARVVVVSGE 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 ----GEAEARSRFDDIVDVHVLDISSPGDADLDEEEF---------AGPTRPANAAFTLFTSGSTGRPKAVVITHRGI-- 146
Cdd:cd05959    111 lapvLAAALTKSEHTLVVLIVSGGAGPEAGALLLAELvaaeaeqlkPAATHADDPAFWLYSSGSTGRPKGVVHLHADIyw 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  147 -ANRLAADIeqYDLTARDVFLYKAPITFDVSV-REIFLPIAIGATLVIaEPGRHgDPVHLADLIRRHGVTVIHFVPAMLA 224
Cdd:cd05959    191 tAELYARNV--LGIREDDVCFSAAKLFFAYGLgNSLTFPLSVGATTVL-MPERP-TPAAVFKRIRRYRPTVFFGVPTLYA 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  225 AFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEAsivVTIHRVTQDDRVIPiGTPTRRV--- 301
Cdd:cd05959    267 AMLAAPNLPSRDLSSLRLCVSAGEALPAEVGERWKARF-GLDILDGIGSTEM---LHIFLSNRPGRVRY-GTTGKPVpgy 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  302 SARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVadpfGEpgarLYRTGDRARWNRDGEIEYLGRTDFQVK 381
Cdd:cd05959    342 EVELRDEDGGDVADGEPGELYVRGPSSATMYWNNRDKTRDTFQ----GE----WTRTGDKYVRDDDGFYTYAGRADDMLK 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  382 LRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADVDVDTVAATT------AELLPEYMRPSAWVRLDA 454
Cdd:cd05959    414 VSGIWVSPFEVESALVQHPAVLEAAVvGVEDEDGLTKPKAFVVLRPGYEDSEALEEelkefvKDRLAPYKYPRWIVFVDE 493

                          490
                   ....*....|....
gi 1827387616  455 MPLSRSGKVDRRLL 468
Cdd:cd05959    494 LPKTATGKIQRFKL 507

PRK06087

medium-chain fatty-acid--CoA ligase;

2566-3065

1.12e-36

medium-chain fatty-acid--CoA ligase;

Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 148.36 E-value: 1.12e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK06087    24 SLADYWQQTARAMPDKIAVVDNHGASYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSVP 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGAV--LGLSVLASGDlPGQEFEWMRLDDDSVAAEIAAVPAGPITDAERLGEVTAAN------- 2716
Cdd:PRK06087   104 LLPSWREAELVWVLNKCQAKmfFAPTLFKQTR-PVDLILPLQNQLPQLQQIVGVDKLAPATSSLSLSQIIADYeplttai 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2717 ------LAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVV-----LGFASPSFDASVLEYLLATVNEGTLA 2785
Cdd:PRK06087   183 tthgdeLAAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQDVFmmpapLGHATGFLHGVTAPFLIGARSVLLDI 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2786 YRPSEAVGGEVLERFIAEHGAthtflTPSVLSTM-----DPTAVPSLRVIAAGGEAVPQPIV-DRWAPATELHNLYGPTE 2859
Cdd:PRK06087   263 FTPDACLALLEQQRCTCMLGA-----TPFIYDLLnllekQPADLSALRFFLCGGTTIPKKVArECQQRGIKLLSVYGSTE 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2860 TTIGITIssamRPGDPVRL-----GGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgt 2934
Cdd:PRK06087   338 SSPHAVV----NLDDPLSRfmhtdGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLDEPELTARALDEEGW-- 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2935 agqrmYRTGDVVRwtpdTDTGGlTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYIVP 3013
Cdd:PRK06087   412 -----YYSGDLCR----MDEAG-YIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDErLGERSCAYVVL 481

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 3014 VDG--AVEVSELKAF-AGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLE 3065
Cdd:PRK06087   482 KAPhhSLTLEEVVAFfSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKDIMR 536

PRK07788

acyl-CoA synthetase; Validated

2566-3061

1.28e-36

acyl-CoA synthetase; Validated

Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 148.15 E-value: 1.28e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK07788    50 PFAGLVAHAARRAPDRAALIDERG-TLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIIL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGAVL--------GLSVLASGDLPGQEFEWMRLDDDSVAAE--------IAAVPAGPITDAERL 2709
Cdd:PRK07788   129 LNTGFSGPQLAEVAAREGVKAlvyddeftDLLSALPPDLGRLRAWGGNPDDDEPSGStdetlddlIAGSSTAPLPKPPKP 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2710 GevtaanlAYVIYTSGSTGRPKGVAVTH-SGLANFArQESDRLNAGDNPVVLgFASPSFDA-SVLEYLLATVNEGTLAYR 2787
Cdd:PRK07788   209 G-------GIVILTSGTTGTPKGAPRPEpSPLAPLA-GLLSRVPFRAGETTL-LPAPMFHAtGWAHLTLAMALGSTVVLR 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2788 ----PSEAVggevleRFIAEHGATHTFLTPSVLSTM---DPTAVP-----SLRVIAAGGEAVPQPIVDRwapATE----- 2850
Cdd:PRK07788   280 rrfdPEATL------EDIAKHKATALVVVPVMLSRIldlGPEVLAkydtsSLKIIFVSGSALSPELATR---ALEafgpv 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2851 LHNLYGPTEttigITISSAMRPGD----PVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDrsgltaer 2926
Cdd:PRK07788   351 LYNLYGSTE----VAFATIATPEDlaeaPGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGFPFEGYTD-------- 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2927 fTANPYGTAGqrMYRTGDVVRWTPDtdtgGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGG-SVAT 3005
Cdd:PRK07788   419 -GRDKQIIDG--LLSSGDVGYFDED----GL-LFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDeEFGQ 490

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 3006 ALAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK07788   491 RLRAFVVKAPGAaLDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547

CBAL

cd05923

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...

1050-1530

1.57e-36

Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 146.89 E-value: 1.57e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALI--CDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:cd05923     15 PDACAIAdpARGLRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVPALINPRLKAAELAE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLE-DSGATVGITDAS--TRARLGESSCEWV--DLADLEAEAESGDDITDTERngsvRLTNLAYLIYTSGSTGRPKAVGV 1202
Cdd:cd05923     95 LIErGEMTAAVIAVDAqvMDAIFQSGVRVLAlsDLVGLGEPESAGPLIEDPPR----EPEQPAFVFYTSGTTGLPKGAVI 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1203 SHTGI---VDFVNSLAKITTGTPEdepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALATVlERDEVTD 1279
Cdd:cd05923    171 PQRAAesrVLFMSTQAGLRHGRHN-----VVLGLMPLYHVIGFFAVLVAALALDGTYVVVEEFDPADALKLI-EQERVTS 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1280 MIITPSVL------ATVDPERAQYVRNLATGGEACPPELVERWSE-RGRRIFNCYGPTEATvwaTRSRMTAGKPVTIGKP 1352
Cdd:cd05923    245 LFATPTHLdalaaaAEFAGLKLSSLRHVTFAGATMPDAVLERVNQhLPGEKVNIYGTTEAM---NSLYMRDARTGTEMRP 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1353 vdGF-----TVRVLDGRLHEVPQGVVGELYLSTAGLA--RGYLGRPGQTAVSFVAdpfgepgaRMYATGDLVRVAKGGNL 1425
Cdd:cd05923    322 --GFfsevrIVRIGGSPDEALANGEEGELIVAAAADAafTGYLNQPEATAKKLQD--------GWYRTGDVGYVDPSGDV 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1426 EFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATidSAAVLDE--AAQHLA 1503
Cdd:cd05923    392 RILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIGVADERWGQS---VTACVVPREGTL--SADELDQfcRASELA 466

                          490       500
                   ....*....|....*....|....*..
gi 1827387616 1504 AHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05923    467 DFKRPRRYFFLDELPKNAMNKVLRRQL 493

PRK06178

acyl-CoA synthetase; Validated

1050-1537

1.93e-36

acyl-CoA synthetase; Validated

Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 148.27 E-value: 1.93e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK06178    47 PQRPAIIFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVHVPVSPLFREHELSYEL 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGIT-DA------STRARLGESSCEWVDLAD-------------LEAEAESGDDITD---TERNGSVR------ 1180
Cdd:PRK06178   127 NDAGAEVLLAlDQlapvveQVRAETSLRHVIVTSLADvlpaeptlplpdsLRAPRLAAAGAIDllpALRACTAPvplppp 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1181 -LTNLAYLIYTSGSTGRPKavGVSHTGiVDFVNSLAKITT-GTPEDEPDtrILHVASPSF--DASMFEMAWAIPAGHTLV 1256
Cdd:PRK06178   207 aLDALAALNYTGGTTGMPK--GCEHTQ-RDMVYTAAAAYAvAVVGGEDS--VFLSFLPEFwiAGENFGLLFPLFSGATLV 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1257 IAPQADfAGDALATVlERDEVTDMIITpsvlatVD--------PERAQY-VRNLATGGEAC-----PPELVERWSE-RGR 1321
Cdd:PRK06178   282 LLARWD-AVAFMAAV-ERYRVTRTVML------VDnavelmdhPRFAEYdLSSLRQVRVVSfvkklNPDYRQRWRAlTGS 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1322 RIFN-CYGPTEATvwaTRSRMTAG----------KPVTIGKPVDGFTVRVLDGRLHE-VPQGVVGELYLSTAGLARGYLG 1389
Cdd:PRK06178   354 VLAEaAWGMTETH---TCDTFTAGfqdddfdllsQPVFVGLPVPGTEFKICDFETGElLPLGAEGEIVVRTPSLLKGYWN 430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1390 RPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTR 1469
Cdd:PRK06178   431 KPEATAEALRDG--------WLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEVEALLGQHPAVLGSAVVGRPDPD 502

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1470 GGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPsQAIVIDEIPLTPAGKLDRAALpEPHAPE 1537
Cdd:PRK06178   503 KGQ---VPVAFVQLKPGADLTAAALQAWCRENMAVYKVP-EIRIVDALPMTATGKVRKQDL-QALAEE 565

MACS_like_2

cd05973

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1064-1530

2.54e-36

Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 144.97 E-value: 2.54e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAST 1143
Cdd:cd05973      3 FGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARLVVTDAAN 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 RARLGEsscewvdladleaeaesgdditdterngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPE 1223
Cdd:cd05973     83 RHKLDS---------------------------------DPFVMMFTSGTTGLPKGVPVPLRALAAFGAYLRDAVDLRPE 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1224 DepdtRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSV---LATVDPERAQYV-- 1298
Cdd:cd05973    130 D----SFWNAADPGWAYGLYYAITGPLALGHPTILLEGGFSVESTWRVIERLGVTNLAGSPTAyrlLMAAGAEVPARPkg 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1299 --RNLATGGEACPPELVeRWSER--GRRIFNCYGPTE-----ATVWATRSRMTAGkpvTIGKPVDGFTVRVLDGRLHEVP 1369
Cdd:cd05973    206 rlRRVSSAGEPLTPEVI-RWFDAalGVPIHDHYGQTElgmvlANHHALEHPVHAG---SAGRAMPGWRVAVLDDDGDELG 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1370 QGVVGELYLSTAGLA----RGYLGRPGQTAVsfvadpfgepgARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELG 1445
Cdd:cd05973    282 PGEPGRLAIDIANSPlmwfRGYQLPDTPAID-----------GGYYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPF 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1446 EIEAVLDAQPGVAQSVVVGVESTrggrKHTEVV-AYLVAKPGaTIDSAAVLDEAAQH----LAAHMVPSQAIVIDEIPLT 1520
Cdd:cd05973    351 DVESALIEHPAVAEAAVIGVPDP----ERTEVVkAFVVLRGG-HEGTPALADELQLHvkkrLSAHAYPRTIHFVDELPKT 425

                          490
                   ....*....|
gi 1827387616 1521 PAGKLDRAAL 1530
Cdd:cd05973    426 PSGKIQRFLL 435

PRK06145

acyl-CoA synthetase; Validated

1050-1525

3.20e-36

acyl-CoA synthetase; Validated

Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 146.18 E-value: 3.20e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK06145    16 PDRAALVYRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVAYIL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDASTRARLGESSCEWVDLADLEAE----AESGDDITDTErngSVRLTNLAYLIYTSGSTGRPKAVGVSHT 1205
Cdd:PRK06145    96 GDAGAKLLLVDEEFDAIVALETPKIVIDAAAQADsrrlAQGGLEIPPQA---AVAPTDLVRLMYTSGTTDRPKGVMHSYG 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1206 GI----VDFVNSLAkITTgtpedepDTRILhVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMI 1281
Cdd:PRK06145   173 NLhwksIDHVIALG-LTA-------SERLL-VVGPLYHVGAFDLPGIAVLWVGGTLRIHREFDPEAVLAAIERHRLTCAW 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1282 ITPSVLATV--DPERAQY----VRNLATGGEACPPELVERWSE--RGRRIFNCYGPTEATVWATrsRMTAGKPV----TI 1349
Cdd:PRK06145   244 MAPVMLSRVltVPDRDRFdldsLAWCIGGGEKTPESRIRDFTRvfTRARYIDAYGLTETCSGDT--LMEAGREIekigST 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1350 GKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAG 1429
Cdd:PRK06145   322 GRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFYGDWF--------RSGDVGYLDEEGFLYLTD 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1430 RADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVaylVAKPGATIDSAAVLDEAAQHLAAHMVPS 1509
Cdd:PRK06145   394 RKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVV---VLNPGATLTLEALDRHCRQRLASFKVPR 470

                          490
                   ....*....|....*.
gi 1827387616 1510 QAIVIDEIPLTPAGKL 1525
Cdd:PRK06145   471 QLKVRDELPRNPSGKV 486

Firefly_Luc_like

cd05911

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...

1-463

3.34e-36

Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 145.82 E-value: 3.34e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd05911     11 LTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPKVIFTDP 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DG-----EAEARSRFDD---IVDVHVLDISSPGDADLDEEEFAGPTRPA-------NAAFTLFTSGSTGRPKAVVITHRG 145
Cdd:cd05911     91 DGlekvkEAAKELGPKDkiiVLDDKPDGVLSIEDLLSPTLGEEDEDLPPplkdgkdDTAAILYSSGTTGLPKGVCLSHRN 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  146 -IAN-RLAADIEQYDLTARDVFLykAPITFDvsvrEIF-LPIAI-----GATLVIAepgRHGDPVHLADLIRRHGVTVIH 217
Cdd:cd05911    171 lIANlSQVQTFLYGNDGSNDVIL--GFLPLY----HIYgLFTTLasllnGATVIIM---PKFDSELFLDLIEKYKITFLY 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  218 FVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASiVVTIHRVTQDDRVIPIGTP 297
Cdd:cd05911    242 LVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNATIKQGYGMTETG-GILTVNPDGDDKPGSVGRL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  298 TRRVSARVLDAALRE-VPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGE------- 369
Cdd:cd05911    321 LPNVEAKIVDDDGKDsLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGW-------LHTGDIGYFDEDGYlyivdrk 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  370 ---IEYLGrtdFQVKLRgqrlelgEVEAALAAAPGVLHAA--------------AAVVDGPGGQqlvgyLAPADVdVDTV 432
Cdd:cd05911    394 kelIKYKG---FQVAPA-------ELEAVLLEHPGVADAAvigipdevsgelprAYVVRKPGEK-----LTEKEV-KDYV 457

                          490       500       510
                   ....*....|....*....|....*....|..
gi 1827387616  433 aattAELLPEYMRPSAWVR-LDAMPLSRSGKV 463
Cdd:cd05911    458 ----AKKVASYKQLRGGVVfVDEIPKSASGKI 485

PRK08314

long-chain-fatty-acid--CoA ligase; Validated

1050-1525

4.43e-36

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 146.64 E-value: 4.43e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYM 1128
Cdd:PRK08314    24 PDKTAIVFYGRAISYRELLEEAERLAGYLQQEcGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPVNPMNREEELAHY 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1129 LEDSGATVGITDASTRARL----GESSCEWV------------------DLADLEAEAESGDDI-----TDTERNG---- 1177
Cdd:PRK08314   104 VTDSGARVAIVGSELAPKVapavGNLRLRHVivaqysdylpaepeiavpAWLRAEPPLQALAPGgvvawKEALAAGlapp 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1178 --SVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVAsPSFDASMFE--MAWAIPAGH 1253
Cdd:PRK08314   184 phTAGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPES----VVLAVL-PLFHVTGMVhsMNAPIYAGA 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1254 TLVIAPQADfaGDALATVLERDEVTDMIITPSVLatVD----PERAQY----VRNLATGGEACPPELVERWSER-GRRIF 1324
Cdd:PRK08314   259 TVVLMPRWD--REAAARLIERYRVTHWTNIPTMV--VDflasPGLAERdlssLRYIGGGGAAMPEAVAERLKELtGLDYV 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1325 NCYGPTEaTVWATRSR-MTAGKPVTIGKPVDGFTVRVLDGR-LHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVA-D 1401
Cdd:PRK08314   335 EGYGLTE-TMAQTHSNpPDRPKLQCLGIPTFGVDARVIDPEtLEELPPGEVGEIVVHGPQVFKGYWNRPEATAEAFIEiD 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1402 pfgepGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYL 1481
Cdd:PRK08314   414 -----GKRFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACVIATPDPRRGE---TVKAVV 485

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616 1482 VAKPGA--TIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKL 1525
Cdd:PRK08314   486 VLRPEArgKTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKI 531

PRK13295

cyclohexanecarboxylate-CoA ligase; Reviewed

2566-3061

8.00e-36

cyclohexanecarboxylate-CoA ligase; Reviewed

Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 145.97 E-value: 8.00e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVD-----GAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTG 2640
Cdd:PRK13295    25 TINDDLDACVASCPDKTAVTAvrlgtGAPRRFTYRELAALVDRVAVGLARLGVGRGDVVSCQLPNWWEFTVLYLACSRIG 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2641 GAYVPIDPDYPAERVASMIEDSGAVLglsVLASGDLPGQEFEWM--RL----------------DDDSVAAEIAAVP--- 2699
Cdd:PRK13295   105 AVLNPLMPIFRERELSFMLKHAESKV---LVVPKTFRGFDHAAMarRLrpelpalrhvvvvggdGADSFEALLITPAweq 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2700 ---AGPITDAERLGevtAANLAYVIYTSGSTGRPKGVAVTH----SGLANFARqesdRLNAGDNPVVLGfASPSFDASVL 2772
Cdd:PRK13295   182 epdAPAILARLRPG---PDDVTQLIYTSGTTGEPKGVMHTAntlmANIVPYAE----RLGLGADDVILM-ASPMAHQTGF 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2773 EY--LLATVNEGTLAYR----PSEAVggevleRFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQP 2840
Cdd:PRK13295   254 MYglMMPVMLGATAVLQdiwdPARAA------ELIRTEGVTFTMASTPFLTDLtravkeSGRPVSSLRTFLCAGAPIPGA 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2841 IVDRWAPATELH--NLYGPTETTIGITIssamRPGDPVRL-----GGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALS 2913
Cdd:PRK13295   328 LVERARAALGAKivSAWGMTENGAVTLT----KLDDPDERasttdGCPLPGVEVRVVDADGAPLPAGQIGRLQVRGCSNF 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2914 RGYLDRSGLTaerftanpyGTAGQRMYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVES 2993
Cdd:PRK13295   404 GGYLKRPQLN---------GTDADGWFDTGDLARIDAD---GYIRI--SGRSKDVIIRGGENIPVVEIEALLYRHPAIAQ 469

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 2994 AVVLGVG----GSVAtalAAYIVPVDGA-VEVSELKAFAGG-RLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK13295   470 VAIVAYPderlGERA---CAFVVPRPGQsLDFEEMVEFLKAqKVAKQYIPERLVVRDALPRTPSGKIQKFRLRE 540

MCS

cd05941

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...

2-468

8.89e-36

Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 143.58 E-value: 8.89e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVA-VGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvts 80
Cdd:cd05941     13 TYADLVARAARLANRLLALGKDLRGDrVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVITDSEPSLVL--- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfddivdvhvldisspgdadldeeefagptrpaNAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd05941     90 -----------------------------------------DPALILYTSGTTGRPKGVVLTHANLAANVRALVDAWRWT 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPItFDVS--VREIFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAML--------AAFNEVL 230
Cdd:cd05941    129 EDDVLLHVLPL-HHVHglVNALLCPLFAGASVEFL---PKFDPKEVAISRLMPSITVFMGVPTIYtrllqyyeAHFTDPQ 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  231 GAGVGELTSLRLIQTGGEALTPPVARDLmVRLPGTRLQNQYGPAEASIVVTiHRVTQDDRVIPIGTPTRRVSARVLD-AA 309
Cdd:cd05941    205 FARAAAAERLRLMVSGSAALPVPTLEEW-EAITGHTLLERYGMTEIGMALS-NPLDGERRPGTVGMPLPGVQARIVDeET 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  310 LREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRT-DFQVKLRGQRLE 388
Cdd:cd05941    283 GEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGW-------FKTGDLGVVDEDGYYWILGRSsVDIIKSGGYKVS 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  389 LGEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGYLAPAD----VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSG 461
Cdd:cd05941    356 ALEIERVLLAHPGV--SECAVIGVPDpdwGERVVAVVVLRAgaaaLSLEELKEWAKQRLAPYKRPRRLILVDELPRNAMG 433


                   ....*..
gi 1827387616  462 KVDRRLL 468
Cdd:cd05941    434 KVNKKEL 440

PRK07470

acyl-CoA synthetase; Validated

2567-3075

1.01e-35

acyl-CoA synthetase; Validated

Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 145.18 E-value: 1.01e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2567 LAELFRAAARRAPDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:PRK07470     9 LAHFLRQAARRFPDRIALVWGDR-SWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVPT 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMIEDSGAVLglsVLASGDLPGQ---------EFEWMRLDDD-----SVAAEIAAVPAGPITDAErlgeV 2712
Cdd:PRK07470    88 NFRQTPDEVAYLAEASGARA---MICHADFPEHaaavraaspDLTHVVAIGGaraglDYEALVARHLGARVANAA----V 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2713 TAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNP--VVLGFASPSFDASVleYLLATVNEG-TLAYRPS 2789
Cdd:PRK07470   161 DHDDPCWFFFTSGTTGRPKAAVLTHGQMAFVITNHLADLMPGTTEqdASLVVAPLSHGAGI--HQLCQVARGaATVLLPS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2790 EAVGGEVLERFIAEHGATHTFLTPSVLSTM--DPTAV----PSLR-VIAAGGeavPQPIVDRWAPATELHNL----YGPT 2858
Cdd:PRK07470   239 ERFDPAEVWALVERHRVTNLFTVPTILKMLveHPAVDrydhSSLRyVIYAGA---PMYRADQKRALAKLGKVlvqyFGLG 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2859 ETTIGITISSA----MRPGDPVRLGG---PIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANp 2931
Cdd:PRK07470   316 EVTGNITVLPPalhdAEDGPDARIGTcgfERTGMEVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNPEANAKAFRDG- 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2932 ygtagqrMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATAL 3007
Cdd:PRK07470   395 -------WFRTGDLGH----LDARGF-LYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVLGVPdpvwGEVGVAV 462

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 3008 aayIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLEAGEYVAPATG 3075
Cdd:PRK07470   463 ---CVARDGApVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVREELEERGLLDLERAP 528

E-C_NRPS

cd19544

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); ...

2108-2530

1.11e-35

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); Dual function Epimerization/Condensation (E/C) domains have both an epimerization and a DCL condensation activity. Dual E/C domains first epimerize the substrate amino acid to produce a D-configuration, then catalyze the condensation between the D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. They are D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L)); this is in contrast with the standard LCL domains which catalyze peptide bond formation between two L-amino acids, and the restriction of ribosomes to use only L-amino acids. These Dual E/C domains contain an extended His-motif (HHx(N)GD) near the N-terminus of the domain in addition to the standard Condensation (C) domain active site motif (HHxxxD). C domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains, these include the DCL-type, LCL-type, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C domains, and the X-domain.

Pssm-ID: 380466 [Multi-domain] Cd Length: 413 Bit Score: 142.58 E-value: 1.11e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQGLFFQADLAntvADHDAidvYVTQTVLSLTgdvDPGRLRS---ALSELLARQRVLRSGFVR--LPsgAAVTVV 2182
Cdd:cd19544      3 PLAPLQEGILFHHLLA---EEGDP---YLLRSLLAFD---SRARLDAflaALQQVIDRHDILRTAILWegLS--EPVQVV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2183 PAEVTVPwsVIDLRAEDAASLDSRVEEVLATERTnPFDMAKPPLIRVVLVEHGDGAE--LVVTNHHLLIDGWSSPLVLAD 2260
Cdd:cd19544     72 WRQAELP--VEELTLDPGDDALAQLRARFDPRRY-RLDLRQAPLLRAHVAEDPANGRwlLLLLFHHLISDHTSLELLLEE 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2261 LLsLYATGQTftGSLPG-TSGRDFADHARAVATAdvEAGIAAWREVLAPVTEPTlvAP---GHEPSADAPPRDHQFSIDV 2336
Cdd:cd19544    149 IQ-AILAGRA--AALPPpVPYRNFVAQARLGASQ--AEHEAFFREMLGDVDEPT--APfglLDVQGDGSDITEARLALDA 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2337 KVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAeTV-SGRSPDIEGMESMVGMFINTIPAVVDVNpDATVVD 2415
Cdd:cd19544    222 ELAQRLRAQARRLGVSPASLFHLAWALVLARCSGRDDVVFG-TVlSGRMQGGAGADRALGMFINTLPLRVRLG-GRSVRE 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2416 VLTAVQNDKVKVLDHQQIGLPrlVAQ--TGLPA---LFDTLAVYESfpvNVDSVAGIDASSAGGLKLVGAKtsDATHYPL 2490
Cdd:cd19544    300 AVRQTHARLAELLRHEHASLA--LAQrcSGVPAptpLFSALLNYRH---SAAAAAAAALAAWEGIELLGGE--ERTNYPL 372

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1827387616 2491 NLSASRRGAELALKLKYLPtAFAPEQV-AVFADVLTGLLGA 2530
Cdd:cd19544    373 TLSVDDLGDGFSLTAQVVA-PIDAERVcAYMETALEQLVDA 412

PRK13295

cyclohexanecarboxylate-CoA ligase; Reviewed

1050-1539

1.35e-35

cyclohexanecarboxylate-CoA ligase; Reviewed

Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 145.20 E-value: 1.35e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALIC------DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:PRK13295    38 PDKTAVTAvrlgtgAPRRFTYRELAALVDRVAVGLARLGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLNPLMPIFRER 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGITDASTR--------ARL----------------GESSCEWVdLADLEAEAESGDD-ITDTERNGS 1178
Cdd:PRK13295   118 ELSFMLKHAESKVLVVPKTFRgfdhaamaRRLrpelpalrhvvvvggdGADSFEAL-LITPAWEQEPDAPaILARLRPGP 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1179 vrlTNLAYLIYTSGSTGRPKavGVSHT------GIVDFVNSLAKittgTPEDepdtrILHVASPSFDAS--MFEMAWAIP 1250
Cdd:PRK13295   197 ---DDVTQLIYTSGTTGEPK--GVMHTantlmaNIVPYAERLGL----GADD-----VILMASPMAHQTgfMYGLMMPVM 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1251 AGHTLVIAPQADFAgdALATVLERDEVT-DMIITP--SVLATVDPERAQYVRNLAT---GGEACPPELVERWSER-GRRI 1323
Cdd:PRK13295   263 LGATAVLQDIWDPA--RAAELIRTEGVTfTMASTPflTDLTRAVKESGRPVSSLRTflcAGAPIPGALVERARAAlGAKI 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNCYGPTEATVwatrsrMTAGKP--------VTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTA 1395
Cdd:PRK13295   341 VSAWGMTENGA------VTLTKLddpderasTTDGCPLPGVEVRVVDADGAPLPAGQIGRLQVRGCSNFGGYLKRPQLNG 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1396 VSfvADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKht 1475
Cdd:PRK13295   415 TD--ADGW-------FDTGDLARIDADGYIRISGRSKDVIIRGGENIPVVEIEALLYRHPAIAQVAIVAYPDERLGER-- 483

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 1476 eVVAYLVAKPGATIDSAAVLD-EAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPEPA 1539
Cdd:PRK13295   484 -ACAFVVPRPGQSLDFEEMVEfLKAQKVAKQYIPERLVVRDALPRTPSGKIQKFRLREMLRGEDA 547

VL_LC_FACS_like

cd05907

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...

1060-1504

1.38e-35

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 143.12 E-value: 1.38e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1060 TEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT 1139
Cdd:cd05907      4 QPITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKALFV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DastrarlgesscewvDLADLeaeaesgdditdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITT 1219
Cdd:cd05907     84 E---------------DPDDL------------------------ATIIYTSGTTGRPKGVMLSHRNILSNALALAERLP 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1220 GTPEDepdtRIL------HVaspsFDASMFEMAWaIPAGHTLVIAPQADFAGDALATVlerdEVTDMIITPSVLATV--- 1290
Cdd:cd05907    125 ATEGD----RHLsflplaHV----FERRAGLYVP-LLAGARIYFASSAETLLDDLSEV----RPTVFLAVPRVWEKVyaa 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1291 -----DPE---------RAQYVRNLATGGEACPPELVERWSERGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGF 1356
Cdd:cd05907    192 ikvkaVPGlkrklfdlaVGGRLRFAASGGAPLPAELLHFFRALGIPVYEGYGLTETSAVVTLNPPGDNRIGTVGKPLPGV 271

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1357 TVRVldgrlhevpqGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRA-DHQV 1435
Cdd:cd05907    272 EVRI----------ADDGEILVRGPNVMLGYYKNPEATAEALDADGW-------LHTGDLGEIDEDGFLHITGRKkDLII 334

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1436 KINGQRVELGEIEAVLDAQPGVAQSVVVGvestrGGRKHteVVAyLVakpgaTIDSAAVLDEAAQHLAA 1504
Cdd:cd05907    335 TSGGKNISPEPIENALKASPLISQAVVIG-----DGRPF--LVA-LI-----VPDPEALEAWAEEHGIA 390

MACS_like

cd05972

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...

2592-3059

2.76e-35

Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 141.71 E-value: 2.76e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAvlglsvl 2671
Cdd:cd05972      1 WSFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGA------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrldddsvaaeiaavpAGPITDAErlgevtaaNLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRL 2751
Cdd:cd05972     74 ----------------------------KAIVTDAE--------DPALIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWL 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGDNPVVLGFASPSFDASVLEYLLATVNEG--TLAYRPSEAVGGEVLErFIAEHGATHTFLTPSVLSTM---DPTA--V 2824
Cdd:cd05972    118 GLRPDDIHWNIADPGWAKGAWSSFFGPWLLGatVFVYEGPRFDAERILE-LLERYGVTSFCGPPTAYRMLikqDLSSykF 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2825 PSLRVIAAGGEAVPQPIVDRWAPATEL--HNLYGPTETTIGITISSAM--RPGdpvRLGGPIGGVDLMVLDERLRPVPVG 2900
Cdd:cd05972    197 SHLRLVVSAGEPLNPEVIEWWRAATGLpiRDGYGQTETGLTVGNFPDMpvKPG---SMGRPTPGYDVAIIDDDGRELPPG 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2901 MPGELYVAGG--ALSRGYLDRSGLTAERFtanpygtaGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIEL 2978
Cdd:cd05972    274 EEGDIAIKLPppGLFLGYVGDPEKTEASI--------RGDYYLTGDRAYRDEDG-----YFWFVGRADDIIKSSGYRIGP 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2979 GEIEAVLAEHDAVESAVVLGVGGSVATALA-AYIVPVDGA----VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGK 3053
Cdd:cd05972    341 FEVESALLEHPAVAEAAVVGSPDPVRGEVVkAFVVLTSGYepseELAEELQGHVKKVLAPYKYPREIEFVEELPKTISGK 420


                   ....*.
gi 1827387616 3054 LDKRAL 3059
Cdd:cd05972    421 IRRVEL 426

CHC_CoA_lg

cd05903

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...

4-470

4.01e-35

Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 141.36 E-value: 4.01e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSdge 83
Cdd:cd05903      5 SELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVVPE--- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aeaRSRFDDIVDVhvldisspgdadldeeefagptrPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05903     82 ---RFRQFDPAAM-----------------------PDAVALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGLGPGD 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPIT-FDVSVREIFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRL 242
Cdd:cd05903    136 VFLVASPMAhQTGFVYGFTLPLLLGAPVVLQ---DIWDPDKALALMREHGVTFMMGATPFLTDLLNAVEEAGEPLSRLRT 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  243 IQTGGEALTPPVARDLMVRLpGTRLQNQYGPAE-ASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGEL 321
Cdd:cd05903    213 FVCGGATVPRSLARRAAELL-GAKVCSAYGSTEcPGAVTSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAPGVEGEL 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  322 YLGGVQLARGYAGRPDLTAErfvADPFGepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPG 401
Cdd:cd05903    292 LSRGPSVFLGYLDRPDLTAD---AAPEG-----WFRTGDLARLDEDGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPG 363

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  402 VLHAA-AAVVDGPGGQQLVGYL---APADVDVDTVAA-TTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:cd05903    364 VIEAAvVALPDERLGERACAVVvtkSGALLTFDELVAyLDRQGVAKQYWPERLVHVDDLPRTPSGKVQKFRLRE 437

PRK06188

acyl-CoA synthetase; Validated

1050-1534

8.27e-35

acyl-CoA synthetase; Validated

Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 142.43 E-value: 8.27e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVgmerSIGSVLATWGVIK----SGAAYVPVDPAYPADRI 1125
Cdd:PRK06188    26 PDRPALVLGDTRLTYGQLADRISRYIQAFEALGLGTGDAVAL----LSLNRPEVLMAIGaaqlAGLRRTALHPLGSLDDH 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1126 AYMLEDSGATVGITDAS---TRAR-LGESS---------CEWVDLADLEAEAESGDDITDTERNGSvrlTNLAYLIYTSG 1192
Cdd:PRK06188   102 AYVLEDAGISTLIVDPApfvERALaLLARVpslkhvltlGPVPDGVDLLAAAAKFGPAPLVAAALP---PDIAGLAYTGG 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1193 STGRPKAVGVSHTGIVDFvnslAKITTGTPEDEPDTRILHVASPSFDASMFemawAIPA---GHTLVIAPQADfAGDALA 1269
Cdd:PRK06188   179 TTGKPKGVMGTHRSIATM----AQIQLAEWEWPADPRFLMCTPLSHAGGAF----FLPTllrGGTVIVLAKFD-PAEVLR 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1270 TVlERDEVTDMIITPSVL-ATVDPERAQyVRNLAT------GGEACPPElveRWSERGRRI----FNCYGPTEA----TV 1334
Cdd:PRK06188   250 AI-EEQRITATFLVPTMIyALLDHPDLR-TRDLSSletvyyGASPMSPV---RLAEAIERFgpifAQYYGQTEApmviTY 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 WATRSRMTA--GKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgepgarMYA 1412
Cdd:PRK06188   325 LRKRDHDPDdpKRLTSCGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWNRPEETAEAFRDG--------WLH 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1413 TGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSA 1492
Cdd:PRK06188   397 TGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGVPDEKWGEA---VTAVVVLRPGAAVDAA 473

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1827387616 1493 AVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPH 1534
Cdd:PRK06188   474 ELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALRARY 515

FACL_fum10p_like

cd05926

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...

4-470

9.77e-35

Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 141.68 E-value: 9.77e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:cd05926     18 ADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEFYLADLGSKLVLTPKGEL 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 ---AEARSRFDD-IVDVHVLDIS----------SPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANR 149
Cdd:cd05926     98 gpaSRAASKLGLaILELALDVGVlirapsaeslSNLLADKKNAKSEGVPLPDDLALILHTSGTTGRPKGVPLTHRNLAAS 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  150 LAADIEQYDLTARDVFLYKAPItFDVS--VREIFLPIAIGATLVIaePGRHgDPVHLADLIRRHGVTVIHFVPAMLAAF- 226
Cdd:cd05926    178 ATNITNTYKLTPDDRTLVVMPL-FHVHglVASLLSTLAAGGSVVL--PPRF-SASTFWPDVRDYNATWYTAVPTIHQILl 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  227 NEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRVTQDDRVI-PIGTPTRrVSARV 305
Cdd:cd05926    254 NRPEPNPESPPPKLRFIRSCSASLPPAVLEALEATF-GAPVLEAYGMTEAAHQMTSNPLPPGPRKPgSVGKPVG-VEVRI 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  306 LDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQ 385
Cdd:cd05926    332 LDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANAEAAFKDGW-------FRTGDLGYLDADGYLFLTGRIKELINRGGE 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  386 RLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSG 461
Cdd:cd05926    405 KISPLEVDGVLLSHPAVLEAVAfGVPDEKYGEEVAAAVVLregASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATG 484


                   ....*....
gi 1827387616  462 KVDRRLLPE 470
Cdd:cd05926    485 KIQRRKVAE 493

PRK07798

acyl-CoA synthetase; Validated

2566-3057

1.34e-34

acyl-CoA synthetase; Validated

Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 141.95 E-value: 1.34e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAgARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK07798     4 NIADLFEAVADAVPDRVALVCGD-RRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVN 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGAV-------LGLSVLA-SGDLPGQEFeWMRLDDDSVAAEI-------AAVPAGpitDAERLG 2710
Cdd:PRK07798    83 VNYRYVEDELRYLLDDSDAValvyereFAPRVAEvLPRLPKLRT-LVVVEDGSGNDLLpgavdyeDALAAG---SPERDF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2711 EVTAANLAYVIYTSGSTGRPKGVAVTHS-------GLANFAR--------QESDRLNAGDNPVVLGfASPSFDASVLEYL 2775
Cdd:PRK07798   159 GERSPDDLYLLYTGGTTGMPKGVMWRQEdifrvllGGRDFATgepiedeeELAKRAAAGPGMRRFP-APPLMHGAGQWAA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2776 LATVNEG--TLAYRPSEAVGGEVLeRFIAEHGATHTFLT------PSV--LSTMDPTAVPSLRVIAAGGEAVPQPIVDRW 2845
Cdd:PRK07798   238 FAALFSGqtVVLLPDVRFDADEVW-RTIEREKVNVITIVgdamarPLLdaLEARGPYDLSSLFAIASGGALFSPSVKEAL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2846 ---APATELHNLYGPTETTIGitiSSAMRPGDPVRLGGP---IGGvDLMVLDERLRPVPVGMPGELYVA-GGALSRGYLD 2918
Cdd:PRK07798   317 lelLPNVVLTDSIGSSETGFG---GSGTVAKGAVHTGGPrftIGP-RTVVLDEDGNPVEPGSGEIGWIArRGHIPLGYYK 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2919 RSGLTAERF-TANpygtaGQRMYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVL 2997
Cdd:PRK07798   393 DPEKTAETFpTID-----GVRYAIPGDRARVEAD---GTITL--LGRGSVCINTGGEKVFPEEVEEALKAHPDVADALVV 462

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2998 GV-----GGSVatalAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKR 3057
Cdd:PRK07798   463 GVpderwGQEV----VAVVQLREGArPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGKADYR 524

LC_FACS_like

cd05935

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...

2591-3059

1.78e-34

Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 139.54 E-value: 1.78e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2591 RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLgLSV 2670
Cdd:cd05935      1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKV-AVV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2671 LASgdlpgqefewmrLDDdsvaaeiaavpagpitdaerlgevtaanLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDR 2750
Cdd:cd05935     80 GSE------------LDD----------------------------LALIPYTSGTTGLPKGCMHTHFSAAANALQSAVW 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2751 LNAGDNPVVLGFAsPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLstMDPTAVP----- 2825
Cdd:cd05935    120 TGLTPSDVILACL-PLFHVTGFVGSLNTAVYVGGTYVLMARWDRETALELIEKYKVTFWTNIPTML--VDLLATPefktr 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2826 ---SLRVIAAGGEAVPQPIVDRWAPATELHNL--YGPTETTIGITISSAMRPGDPVrLGGPIGGVDLMVLD-ERLRPVPV 2899
Cdd:cd05935    197 dlsSLKVLTGGGAPMPPAVAEKLLKLTGLRFVegYGLTETMSQTHTNPPLRPKLQC-LGIP*FGVDARVIDiETGRELPP 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2900 GMPGELYVAGGALSRGYLDRSGLTAERFTAnpygTAGQRMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELG 2979
Cdd:cd05935    276 NEVGEIVVRGPQIFKGYWNRPEETEESFIE----IKGRRFFRTGDLGY----MDEEGY-FFFVDRVKRMINVSGFKVWPA 346

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2980 EIEAVLAEHDAVESAVVLGV----GGSVATALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLD 3055
Cdd:cd05935    347 EVEAKLYKHPAI*EVCVISVpderVGEEVKAFIVLRPEYRGKVTEEDIIEWAREQMAAYKYPREVEFVDELPRSASGKIL 426


                   ....
gi 1827387616 3056 KRAL 3059
Cdd:cd05935    427 WRLL 430

C_NRPS-like

cd19537

Condensation family domain with an atypical active site motif; Condensation (C) domains of ...

572-996

1.97e-34

Condensation family domain with an atypical active site motif; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Members of this subfamily typically have a non-canonical conserved SHXXXDX(14)Y motif. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380460 [Multi-domain] Cd Length: 395 Bit Score: 138.47 E-value: 1.97e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  572 PLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVAVAREQLD- 650
Cdd:cd19537      3 ALSPIEREWWHKYQLSTGTSSFNVSFACRLSGDVDRDRLASAWNTVLARHRILRSRYVPRDGGLRRSYSSSPPRVQRVDt 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  651 ---WREADsveslvRSttegFDVSTQMPLRGRFHRDgaglHVALTMHHIAMDGQSIPVLARDLMSAYaaraegRTGGLPV 727
Cdd:cd19537     83 ldvWKEIN------RP----FDLEREDPIRVFISPD----TLLVVMSHIICDLTTLQLLLREVSAAY------NGKLLPP 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  728 LDVQYADYALWQQsvlgdaddetSVLGEQLSHWRRVLAGLPaVTDLPmdrPRPAVLGTAGATVTVEFDDDLADRVDVLAR 807
Cdd:cd19537    143 VRREYLDSTAWSR----------PASPEDLDFWSEYLSGLP-LLNLP---RRTSSKSYRGTSRVFQLPGSLYRSLLQFST 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  808 SNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPALEELIGMFVNTLLLRTQVDP--GHSVGDLLGNVRTTVLDA 885
Cdd:cd19537    209 SSGITLHQLALAAVALALQDLSDRTDIVLGAPYLNRTSEEDMETVGLFLEPLPIRIRFPSssDASAADFLRAVRRSSQAA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  886 FANdQVQFDELIEALAPERSSSHQPLAQIAFTYTEPT----VNDVAGLEASGIQAapvdTGvvnAKFDLTVAVRARSGGT 961
Cdd:cd19537    289 LAH-AIPWHQLLEHLGLPPDSPNHPLFDVMVTFHDDRgvslALPIPGVEPLYTWA----EG---AKFPLMFEFTALSDDS 360

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1827387616  962 pMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19537    361 -LLLRLEYDTDCFSEEEIDRIESLILAALELLVEG 394

PRK05605

long-chain-fatty-acid--CoA ligase; Validated

2566-3068

2.15e-34

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 142.06 E-value: 2.15e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK05605    33 TLVDLYDNAVARFGDRPAL-DFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFYAVLRLGAVVVE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVASMIEDSGA------------VLGL----------SVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGP- 2702
Cdd:PRK05605   112 HNPLYTAHELEHPFEDHGArvaivwdkvaptVERLrrttpletivSVNMIAAMPLLQRLALRLPIPALRKARAALTGPAp 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2703 -------ITDAERLG--------EVTAANLAYVIYTSGSTGRPKGVAVTHSGL-ANFARQESDRLNAGDNPVVLGFASPS 2766
Cdd:PRK05605   192 gtvpwetLVDAAIGGdgsdvshpRPTPDDVALILYTSGTTGKPKGAQLTHRNLfANAAQGKAWVPGLGDGPERVLAALPM 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2767 FDAsvleYLLaTVNeGTLAYrpseAVGGE-VLerfiaehgaTHTFLTPSVLSTMD---PT---AVPSL--RVIAA----- 2832
Cdd:PRK05605   272 FHA----YGL-TLC-LTLAV----SIGGElVL---------LPAPDIDLILDAMKkhpPTwlpGVPPLyeKIAEAaeerg 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2833 -----------GGEAVPQPIVDRWAPAT--ELHNLYGPTETT---IGITISSAMRPGdpvRLGGPIGGVDLMVLD-ERL- 2894
Cdd:PRK05605   333 vdlsgvrnafsGAMALPVSTVELWEKLTggLLVEGYGLTETSpiiVGNPMSDDRRPG---YVGVPFPDTEVRIVDpEDPd 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2895 RPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGL 2974
Cdd:PRK05605   410 ETMPDGEEGELLVRGPQVFKGYWNRPEETAKSFLDG--------WFRTGDVVVMEED---GFIRI--VDRIKELIITGGF 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2975 RIELGEIEAVLAEHDAVESAVVLGV-GGSVATALAAYIVPVDGAV-EVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVG 3052
Cdd:PRK05605   477 NVYPAEVEEVLREHPGVEDAAVVGLpREDGSEEVVAAVVLEPGAAlDPEGLRAYCREHLTRYKVPRRFYHVDELPRDQLG 556

                          570
                   ....*....|....*.
gi 1827387616 3053 KLDKRALPEPVLEAGE 3068
Cdd:PRK05605   557 KVRRREVREELLEKLG 572

PRK12406

long-chain-fatty-acid--CoA ligase; Provisional

1054-1534

2.54e-34

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 140.60 E-value: 2.54e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1054 ALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSG 1133
Cdd:PRK12406     4 TIISGDRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1134 ATVGITDASTRARLGESSCEWVDLADLEAEAE-----SGDDITDTERNGSV---------------RLTNLAYLIYTSGS 1193
Cdd:PRK12406    84 ARVLIAHADLLHGLASALPAGVTVLSVPTPPEiaaayRISPALLTPPAGAIdwegwlaqqepydgpPVPQPQSMIYTSGT 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1194 TGRPKAVgvshtgivdfvnslaKITTGTPED--------------EPDTRIL------HVASPSFDASmfemawAIPAGH 1253
Cdd:PRK12406   164 TGHPKGV---------------RRAAPTPEQaaaaeqmraliyglKPGIRALltgplyHSAPNAYGLR------AGRLGG 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1254 TLVIAPQadFAGDALATVLERDEVTDMIITPSV---LATVDPE-RAQY----VRNLATGGEACPPE----LVERWserGR 1321
Cdd:PRK12406   223 VLVLQPR--FDPEELLQLIERHRITHMHMVPTMfirLLKLPEEvRAKYdvssLRHVIHAAAPCPADvkraMIEWW---GP 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1322 RIFNCYGPTE--ATVWATrSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLAR-GYLGRPGQTAVSF 1398
Cdd:PRK12406   298 VIYEYYGSTEsgAVTFAT-SEDALSHPGTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPEKRAEID 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1399 VADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVV 1478
Cdd:PRK12406   377 RGG--------FITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEA---LM 445

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 1479 AYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPH 1534
Cdd:PRK12406   446 AVVEPQPGATLDEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDPY 501

LC_FACS_like

cd05935

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...

4-468

3.15e-34

Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 138.77 E-value: 3.15e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDge 83
Cdd:cd05935      5 LELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVGSE-- 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aearsrFDDIvdvhvldisspgdadldeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05935     83 ------LDDL------------------------------ALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTGLTPSD 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPItFDVS--VREIFLPIAIGATLVIAepGRHgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLR 241
Cdd:cd05935    127 VILACLPL-FHVTgfVGSLNTAVYVGGTYVLM--ARW-DRETALELIEKYKVTFWTNIPTMLVDLLATPEFKTRDLSSLK 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  242 LIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEASIVVTIHRvTQDDRVIPIGTPTRRVSARVLDA-ALREVPIGVPGE 320
Cdd:cd05935    203 VLTGGGAPMPPAVAEKLL-KLTGLRFVEGYGLTETMSQTHTNP-PLRPKLQCLGIP*FGVDARVIDIeTGRELPPNEVGE 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  321 LYLGGVQLARGYAGRPDLTAERFVADpfgePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAP 400
Cdd:cd05935    281 IVVRGPQIFKGYWNRPEETEESFIEI----KGRRFFRTGDLGYMDEEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHP 356

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  401 GVLHAAA-AVVDGPGGQQLVGY--LAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05935    357 AI*EVCViSVPDERVGEEVKAFivLRPeyrGKVTEEDIIEWAREQMAAYKYPREVEFVDELPRSASGKILWRLL 430

ttLC_FACS_AlkK_like

cd12119

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...

2570-3059

4.06e-34

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.

Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 140.07 E-value: 4.06e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2570 LFRAAARRAPDHVAV---VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:cd12119      1 LLEHAARLHGDREIVsrtHEGEVHRYTYAEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMI---ED-----SGAVLGLSVLASGDLPGQEfEWMRLDDDSVAAEIAAVPAG----------PITDAER 2708
Cdd:cd12119     81 NPRLFPEQIAYIInhaEDrvvfvDRDFLPLLEAIAPRLPTVE-HVVVMTDDAAMPEPAGVGVLayeellaaesPEYDWPD 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2709 LGEVTAANLAYviyTSGSTGRPKGVAVTHSG--LANFARQESDRLNAGDNPVVLGFAsPSFDASV--LEYllATVNEGTL 2784
Cdd:cd12119    160 FDENTAAAICY---TSGTTGNPKGVVYSHRSlvLHAMAALLTDGLGLSESDVVLPVV-PMFHVNAwgLPY--AAAMVGAK 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2785 AYRPSEAVGGEVLERFIAEHGATHTFLTPSV----LSTMD--PTAVPSLRVIAAGGEAVPQPIVDRWAPA-TELHNLYGP 2857
Cdd:cd12119    234 LVLPGPYLDPASLAELIEREGVTFAAGVPTVwqglLDHLEanGRDLSSLRRVVIGGSAVPRSLIEAFEERgVRVIHAWGM 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2858 TET-TIGI--TISSAMRPGDP-----VRL--GGPIGGVDLMVLDERLRPVPV-GMP-GELYVAGGALSRGYLDRSGlTAE 2925
Cdd:cd12119    314 TETsPLGTvaRPPSEHSNLSEdeqlaLRAkqGRPVPGVELRIVDDDGRELPWdGKAvGELQVRGPWVTKSYYKNDE-ESE 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2926 RFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----G 3001
Cdd:cd12119    393 ALTEDGW-------LRTGDVATIDED---GYLTI--TDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPhpkwG 460

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 3002 SVATALaayIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd12119    461 ERPLAV---VVLKEGAtVTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKAL 516

MACS_like

cd05972

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...

2-468

4.78e-34

Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 138.24 E-value: 4.78e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:cd05972      2 SFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDAE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 geaearsrfddivdvhvldisspgdadldeeefagptrpaNAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTA 161
Cdd:cd05972     82 ----------------------------------------DPALIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWLGLRP 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  162 RDVFLYKAP---ITFDVSvrEIFLPIAIGATLVIAEpGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGvGELT 238
Cdd:cd05972    122 DDIHWNIADpgwAKGAWS--SFFGPWLLGATVFVYE-GPRFDAERILELLERYGVTSFCGPPTAYRMLIKQDLSS-YKFS 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 SLRLIQTGGEALTPPVArDLMVRLPGTRLQNQYGPAEASIVVTIHRvTQDDRVIPIGTPTRRVSARVLDAALREVPIGVP 318
Cdd:cd05972    198 HLRLVVSAGEPLNPEVI-EWWRAATGLPIRDGYGQTETGLTVGNFP-DMPVKPGSMGRPTPGYDVAIIDDDGRELPPGEE 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GEL--YLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAAL 396
Cdd:cd05972    276 GDIaiKLPPPGLFLGYVGDPEKTEASIRGD--------YYLTGDRAYRDEDGYFWFVGRADDIIKSSGYRIGPFEVESAL 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  397 AAAPGVLHAAAAVVDGPGGQQLV--------GYLaPADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05972    348 LEHPAVAEAAVVGSPDPVRGEVVkafvvltsGYE-PSEELAEELQGHVKKVLAPYKYPREIEFVEELPKTISGKIRRVEL 426

CBAL

cd05923

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...

1-468

5.65e-34

Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 139.18 E-value: 5.65e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd05923     29 LTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVPALINPRLKAAELAELIERGEMTAAVIAV 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAeARSRFDDIVDVHVLDIsspgDADLDEEEFAGP------TRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADI 154
Cdd:cd05923    109 DAQV-MDAIFQSGVRVLALSD----LVGLGEPESAGPliedppREPEQPAFVFYTSGTTGLPKGAVIPQRAAESRVLFMS 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  155 EQYDLT--ARDVFLYKAPITFDVSVREIFL-PIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLG 231
Cdd:cd05923    184 TQAGLRhgRHNVVLGLMPLYHVIGFFAVLVaALALDGTYVVV---EEFDPADALKLIEQERVTSLFATPTHLDALAAAAE 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  232 AGVGELTSLRLIQTGGEALTPPVARDLMVRLPGtRLQNQYGPAEASIVVTIHRVTQDDRVIPiGTPTRRVSARVLDAALR 311
Cdd:cd05923    261 FAGLKLSSLRHVTFAGATMPDAVLERVNQHLPG-EKVNIYGTTEAMNSLYMRDARTGTEMRP-GFFSEVRIVRIGGSPDE 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  312 EVPIGVPGELY--LGGVQLARGYAGRPDLTAERFVadpfgepgARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLEL 389
Cdd:cd05923    339 ALANGEEGELIvaAAADAAFTGYLNQPEATAKKLQ--------DGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHP 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  390 GEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADVDV-----DTVAATTAelLPEYMRPSAWVRLDAMPLSRSGKV 463
Cdd:cd05923    411 SEIERVLSRHPGVTEVVViGVADERWGQSVTACVVPREGTLsadelDQFCRASE--LADFKRPRRYFFLDELPKNAMNKV 488


                   ....*
gi 1827387616  464 DRRLL 468
Cdd:cd05923    489 LRRQL 493

PRK08314

long-chain-fatty-acid--CoA ligase; Validated

2560-3061

5.80e-34

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 140.10 E-value: 5.80e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2560 PATdpvTLAELFRAAARRAPDHVAVVdGAGARLTYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAK 2638
Cdd:PRK08314     8 PET---SLFHNLEVSARRYPDKTAIV-FYGRAISYRELLEEAERLAGYLQQEcGVRKGDRVLLYMQNSPQFVIAYYAILR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2639 TGGAYVPIDPDYPAERVASMIEDSGAVLGL--SVLASGDLPGQEFEWMR----------LDDDS---------VAAEIAA 2697
Cdd:PRK08314    84 ANAVVVPVNPMNREEELAHYVTDSGARVAIvgSELAPKVAPAVGNLRLRhvivaqysdyLPAEPeiavpawlrAEPPLQA 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2698 VPAG---PITDAERLG------EVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFAsPSFD 2768
Cdd:PRK08314   164 LAPGgvvAWKEALAAGlappphTAGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESVVLAVL-PLFH 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2769 ASVLEY-LLATVNEG-TLAYRP---SEAVGgevleRFIAEHGATHTFLTPsvlsTM--DPTAVP--------SLRVIAAG 2833
Cdd:PRK08314   243 VTGMVHsMNAPIYAGaTVVLMPrwdREAAA-----RLIERYRVTHWTNIP----TMvvDFLASPglaerdlsSLRYIGGG 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2834 GEAVPQPIVDRWAPATELHNL--YGPTETTIGITISSAMRPgDPVRLGGPIGGVDLMVLD-ERLRPVPVGMPGELYVAGG 2910
Cdd:PRK08314   314 GAAMPEAVAERLKELTGLDYVegYGLTETMAQTHSNPPDRP-KLQCLGIPTFGVDARVIDpETLEELPPGEVGEIVVHGP 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2911 ALSRGYLDRSGLTAERFTAnpygTAGQRMYRTGDVvrwtpdtdtggltleytGRSD--------DQVK----LRGLRIEL 2978
Cdd:PRK08314   393 QVFKGYWNRPEATAEAFIE----IDGKRFFRTGDL-----------------GRMDeegyffitDRLKrminASGFKVWP 451

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2979 GEIEAVLAEHDAVESAVVLGV-----GGSVatalAAYIVPVD---GAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTP 3050
Cdd:PRK08314   452 AEVENLLYKHPAIQEACVIATpdprrGETV----KAVVVLRPearGKTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSG 527

                          570
                   ....*....|.
gi 1827387616 3051 VGKLDKRALPE 3061
Cdd:PRK08314   528 SGKILWRQLQE 538

A_NRPS_TubE_like

cd05906

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...

2560-3059

8.93e-34

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 139.72 E-value: 8.93e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2560 PATDPVTLAELFRAAARRAPDHVAV---VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAV 2636
Cdd:cd05906      5 PEGAPRTLLELLLRAAERGPTKGITyidADGSEEFQSYQDLLEDARRLAAGLRQLGLRPGDSVILQFDDNEDFIPAFWAC 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2637 AKTGGAYVPIDP----DYPAERVASM-----IEDSGAVLGLSVLASgDLPGQEFEWMRLDDDSVAAEIAAVPAGPitdaE 2707
Cdd:cd05906     85 VLAGFVPAPLTVpptyDEPNARLRKLrhiwqLLGSPVVLTDAELVA-EFAGLETLSGLPGIRVLSIEELLDTAAD----H 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2708 RLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASpsFD--ASVLEYLLATVNEGTL- 2784
Cdd:cd05906    160 DLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNGLTPQDVFLNWVP--LDhvGGLVELHLRAVYLGCQq 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2785 AYRPSEAVGGEVLE--RFIAEHGATHTF--------LTPSVLSTMDPTA-VPSLRVIAAGGEAVPQPIVDRW-------- 2845
Cdd:cd05906    238 VHVPTEEILADPLRwlDLIDRYRVTITWapnfafalLNDLLEEIEDGTWdLSSLRYLVNAGEAVVAKTIRRLlrllepyg 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2846 APATELHNLYGPTETTIGITISSAMRPGDP------VRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDR 2919
Cdd:cd05906    318 LPPDAIRPAFGMTETCSGVIYSRSFPTYDHsqalefVSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNN 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2920 SGLTAERFTANPYgtagqrmYRTGDVVRwtpdTDTGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV 2999
Cdd:cd05906    398 PEANAEAFTEDGW-------FRTGDLGF----LDNGNLTI--TGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPSFTAAF 464

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 3000 G----GSVATALAAYIVPV----DGAVEVSE------LKAFagGRLPAYMVPssfTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05906    465 AvrdpGAETEELAIFFVPEydlqDALSETLRairsvvSREV--GVSPAYLIP---LPKEEIPKTSLGKIQRSKL 533

PRK06155

crotonobetaine/carnitine-CoA ligase; Provisional

2547-3061

1.24e-33

crotonobetaine/carnitine-CoA ligase; Provisional

Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 139.12 E-value: 1.24e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2547 AEAAVELTPVTGGPATDpVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRS 2626
Cdd:PRK06155     4 LGAGLAARAVDPLPPSE-RTLPAMLARQAERYPDRPLLVFG-GTRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2627 AQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVL------GLSVLAS---GDLPGQEFeWmRLDDD---SVAAE 2694
Cdd:PRK06155    82 IEFLDVFLGCAWLGAIAVPINTALRGPQLEHILRNSGARLlvveaaLLAALEAadpGDLPLPAV-W-LLDAPasvSVPAG 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2695 IAAVPAGPITDAERLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFAsPSFDASVLEY 2774
Cdd:PRK06155   160 WSTAPLPPLDAPAPAAAVQPGDTAAILYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADDVLYTTL-PLFHTNALNA 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2775 LL-ATVNEGTLAyrpseavggeVLERF--------IAEHGATHTFLTPSVLSTMDP-TAVPSLR---VIAAGGEAVPQPI 2841
Cdd:PRK06155   239 FFqALLAGATYV----------LEPRFsasgfwpaVRRHGATVTYLLGAMVSILLSqPARESDRahrVRVALGPGVPAAL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2842 VD--RWAPATELHNLYGPTETT--IGITISSAmRPGDPVRLGgpiGGVDLMVLDERLRPVPVGMPGELYVAG---GALSR 2914
Cdd:PRK06155   309 HAafRERFGVDLLDGYGSTETNfvIAVTHGSQ-RPGSMGRLA---PGFEARVVDEHDQELPDGEPGELLLRAdepFAFAT 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2915 GYLDRSGLTAErftanpygtAGQRM-YRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVES 2993
Cdd:PRK06155   385 GYFGMPEKTVE---------AWRNLwFHTGDRVVRDADGW-----FRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAA 450

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2994 AVVLGVGGSVAT-ALAAYIVPVDG-AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK06155   451 AAVFPVPSELGEdEVMAAVVLRDGtALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLRE 520

ttLC_FACS_AlkK_like

cd12119

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...

1060-1530

1.81e-33

Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 138.15 E-value: 1.81e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1060 TEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT 1139
Cdd:cd12119     24 HRYTYAEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DASTRARLGESSCEW--------------------VDLADLEAEAESGDDITD----TERNGSVrltnlayLIYTSGSTG 1195
Cdd:cd12119    104 DRDFLPLLEAIAPRLptvehvvvmtddaampepagVGVLAYEELLAAESPEYDwpdfDENTAAA-------ICYTSGTTG 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1196 RPKAVGVSHTGIVdfVNSLAKITT-GTPEDEPDTrILHVAsPSFDAsmfeMAWAIP-----AGHTLVIaPQADFAGDALA 1269
Cdd:cd12119    177 NPKGVVYSHRSLV--LHAMAALLTdGLGLSESDV-VLPVV-PMFHV----NAWGLPyaaamVGAKLVL-PGPYLDPASLA 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1270 TVLERDEVTDMIITPSVLATV--DPERAQY----VRNLATGGEACPPELVERWSERGRRIFNCYGPTEATVWATRSRMTA 1343
Cdd:cd12119    248 ELIEREGVTFAAGVPTVWQGLldHLEANGRdlssLRRVVIGGSAVPRSLIEAFEERGVRVIHAWGMTETSPLGTVARPPS 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 GKP-----------VTIGKPVDGFTVRVLDGRLHEVPQ--GVVGELYLSTAGLARGYLGRPGQTAvSFVADPFgepgarm 1410
Cdd:cd12119    328 EHSnlsedeqlalrAKQGRPVPGVELRIVDDDGRELPWdgKAVGELQVRGPWVTKSYYKNDEESE-ALTEDGW------- 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1411 YATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHtevVAYLVAKPGATID 1490
Cdd:cd12119    400 LRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGERP---LAVVVLKEGATVT 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1827387616 1491 SAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd12119    477 AEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKAL 516

PRK05605

long-chain-fatty-acid--CoA ligase; Validated

1033-1527

2.15e-33

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 138.98 E-value: 2.15e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1033 EVEAGTLIDVLAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGA 1111
Cdd:PRK05605    28 DYGDTTLVDLYDNAvARFGDRPALDFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFYAVLRLGA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1112 AYVPVDPAYPADRIAYMLEDSGATVGI--------------------------TDA-----------------STRARLG 1148
Cdd:PRK05605   108 VVVEHNPLYTAHELEHPFEDHGARVAIvwdkvaptverlrrttpletivsvnmIAAmpllqrlalrlpipalrKARAALT 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1149 ESSCEWVDLADLEAEAESGDDITDTERngSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIvdFVNsLAKITTGTPEDEPDT 1228
Cdd:PRK05605   188 GPAPGTVPWETLVDAAIGGDGSDVSHP--RPTPDDVALILYTSGTTGKPKGAQLTHRNL--FAN-AAQGKAWVPGLGDGP 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1229 RILHVASPSFDASMFEM--AWAIPAGHTLVIAPQADFagDALATVLERDEVTDMIITPSV---LATVDPERA---QYVRN 1300
Cdd:PRK05605   263 ERVLAALPMFHAYGLTLclTLAVSIGGELVLLPAPDI--DLILDAMKKHPPTWLPGVPPLyekIAEAAEERGvdlSGVRN 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1301 LATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAG-KPVTIGKPVDGFTVRVLDGR--LHEVPQGVVGEL 1376
Cdd:PRK05605   341 AFSGAMALPVSTVELWEKLtGGLLVEGYGLTETSPIIVGNPMSDDrRPGYVGVPFPDTEVRIVDPEdpDETMPDGEEGEL 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1377 YLSTAGLARGYLGRPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPG 1456
Cdd:PRK05605   421 LVRGPQVFKGYWNRPEETAKSFLDG--------WFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVLREHPG 492

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1457 VAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:PRK05605   493 VEDAAVVGLPREDGSE---EVVAAVVLEPGAALDPEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRR 560

FAA1

COG1022

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

1027-1501

3.73e-33

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 138.69 E-value: 3.73e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1027 MVGRGGEVEAGTLIDVLAQR-DLDPDHPALIC--DG--TEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVL 1101
Cdd:COG1022      1 MSEFSDVPPADTLPDLLRRRaARFPDRVALREkeDGiwQSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1102 ATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITD--------ASTRARL------------GESSCEWV-DLADL 1160
Cdd:COG1022     81 ADLAILAAGAVTVPIYPTSSAEEVAYILNDSGAKVLFVEdqeqldklLEVRDELpslrhivvldprGLRDDPRLlSLDEL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1161 EAE-AESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRIL------HV 1233
Cdd:COG1022    161 LALgREVADPAELEARRAAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGD----RTLsflplaHV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1234 AspsfdASMFEMAwAIPAGHTLVIAPQADFAGDALATV-----------LER--DEVTDMI------------------- 1281
Cdd:COG1022    237 F-----ERTVSYY-ALAAGATVAFAESPDTLAEDLREVkptfmlavprvWEKvyAGIQAKAeeagglkrklfrwalavgr 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1282 ---------ITPSVLatvdpERAQY------------------VRNLATGGEACPPELVERWSERGRRIFNCYGPTEATV 1334
Cdd:COG1022    311 ryararlagKSPSLL-----LRLKHaladklvfsklrealggrLRFAVSGGAALGPELARFFRALGIPVLEGYGLTETSP 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 WATRSRMTAGKPVTIGKPVDGFTVRVldgrlhevpqGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATG 1414
Cdd:COG1022    386 VITVNRPGDNRIGTVGPPLPGVEVKI----------AEDGEILVRGPNVMKGYYKNPEATAEAFDADGW-------LHTG 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQVKI-NGQRVELGEIEAVLDAQPGVAQSVVVGvestrGGRKHteVVAyLVakpgaTIDSAA 1493
Cdd:COG1022    449 DIGELDEDGFLRITGRKKDLIVTsGGKNVAPQPIENALKASPLIEQAVVVG-----DGRPF--LAA-LI-----VPDFEA 515


                   ....*...
gi 1827387616 1494 VLDEAAQH 1501
Cdd:COG1022    516 LGEWAEEN 523

PRK06164

acyl-CoA synthetase; Validated

2557-3049

5.40e-33

acyl-CoA synthetase; Validated

Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 137.18 E-value: 5.40e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2557 TGGPATDPVTLAELFRAAARRAPDHVAVVDGAGArLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAV 2636
Cdd:PRK06164     2 PHDAAPRADTLASLLDAHARARPDAVALIDEDRP-LSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2637 AKTGGAYVPIDPDYPAERVASMIEDSGAVL----------------------------GLSVL--ASGDLPGqefewmRL 2686
Cdd:PRK06164    81 ARLGATVIAVNTRYRSHEVAHILGRGRARWlvvwpgfkgidfaailaavppdalpplrAIAVVddAADATPA------PA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2687 DDDSVAAEIAAVPAGPITDAERLGEVTAANLAYViyTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGfASPS 2766
Cdd:PRK06164   155 PGARVQLFALPDPAPPAAAGERAADPDAGALLFT--TSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGAVLLA-ALPF 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2767 FDASVLEYLLATVNEG-TLAYRPseAVGGEVLERFIAEHGATHTFLTPSVLSTMDPTA-----VPSLRVI-----AAGGE 2835
Cdd:PRK06164   232 CGVFGFSTLLGALAGGaPLVCEP--VFDAARTARALRRHRVTHTFGNDEMLRRILDTAgeradFPSARLFgfasfAPALG 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2836 AVPQPIVDRWAPateLHNLYGPTETtigITISSAMRPGDPVRLGGPIGGVdLMVLDERLRPV--------PVGMPGELYV 2907
Cdd:PRK06164   310 ELAALARARGVP---LTGLYGSSEV---QALVALQPATDPVSVRIEGGGR-PASPEARVRARdpqdgallPDGESGEIEI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2908 AGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTleYTGRSDDQVKLRGLRIELGEIEAVLAE 2987
Cdd:PRK06164   383 RAPSLMRGYLDNPDATARALTDDGY-------FRTGDLGYTRGD---GQFV--YQTRMGDSLRLGGFLVNPAEIEHALEA 450

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 2988 HDAVESAVVLGVGGSVATALAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLT 3049
Cdd:PRK06164   451 LPGVAAAQVVGATRDGKTVPVAFVIPTDGAsPDEAGLMAACREALAGFKVPARVQVVEAFPVT 513

PRK09088

acyl-CoA synthetase; Validated

4-476

1.29e-32

acyl-CoA synthetase; Validated

Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 134.93 E-value: 1.29e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVvTSDGE 83
Cdd:PRK09088    26 AELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSASELDALLQDAEPRLLL-GDDAV 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSrfdDIVDVHVLdISSPGDADLDEEEFAGPTRPAnaaFTLFTSGSTGRPKAVVITHRgiaNRLAADIEQYDLT--- 160
Cdd:PRK09088   105 AAGRT---DVEDLAAF-IASADALEPADTPSIPPERVS---LILFTSGTSGQPKGVMLSER---NLQQTAHNFGVLGrvd 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAP----ITFDVSVREIflpIAIGATLVIA---EP----GRHGDPvhlaDLirrhGVTVIHFVPAMLAAFNEV 229
Cdd:PRK09088   175 AHSSFLCDAPmfhiIGLITSVRPV---LAVGGSILVSngfEPkrtlGRLGDP----AL----GITHYFCVPQMAQAFRAQ 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  230 LGAGVGELTSLRLIQTGGealTPPVARDLMVRLP-GTRLQNQYGPAEASIV--VTIHRVTQDDRVIPIGTPTRRVSARVL 306
Cdd:PRK09088   244 PGFDAAALRHLTALFTGG---APHAAEDILGWLDdGIPMVDGFGMSEAGTVfgMSVDCDVIRAKAGAAGIPTPTVQTRVV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  307 DAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQR 386
Cdd:PRK09088   321 DDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAFTGDGW-------FRTGDIARRDADGFFWVVDRKKDMFISGGEN 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  387 LELGEVEAALAAAPGVLHAAA-AVVDGPGGQqlVGYLA-----PADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRS 460
Cdd:PRK09088   394 VYPAEIEAVLADHPGIRECAVvGMADAQWGE--VGYLAivpadGAPLDLERIRSHLSTRLAKYKVPKHLRLVDALPRTAS 471

                          490
                   ....*....|....*.
gi 1827387616  461 GKVDRRLLPEPEIAPT 476
Cdd:PRK09088   472 GKLQKARLRDALAAGR 487

PRK08316

acyl-CoA synthetase; Validated

4-468

1.69e-32

acyl-CoA synthetase; Validated

Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 135.45 E-value: 1.69e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD-- 81
Cdd:PRK08316    40 AELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAVHVPVNFMLTGEELAYILDHSGARAFLVDPAla 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEARSRFDDIVDVHVLDISSPGDADLDEEEF-----AGPTRPANAAFT-------LFTSGSTGRPKAVVITHRGIANR 149
Cdd:PRK08316   120 PTAEAALALLPVDTLILSLVLGGREAPGGWLDFadwaeAGSVAEPDVELAdddlaqiLYTSGTESLPKGAMLTHRALIAE 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  150 LAADIEQYDLTARDVFLYKAPItFDVSVREIFL-P-IAIGATLVIAE-PgrhgDPVHLADLIRRHGVTVIhFVP-----A 221
Cdd:PRK08316   200 YVSCIVAGDMSADDIPLHALPL-YHCAQLDVFLgPyLYVGATNVILDaP----DPELILRTIEAERITSF-FAPptvwiS 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  222 ML--AAFNEVlgagvgELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVT-QDDRVIPIGTPT 298
Cdd:PRK08316   274 LLrhPDFDTR------DLSSLRKGYYGASIMPVEVLKELRERLPGLRFYNCYGQTEIAPLATVLGPEeHLRRPGSAGRPV 347

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  299 RRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDF 378
Cdd:PRK08316   348 LNVETRVVDDDGNDVAPGEVGEIVHRSPQLMLGYWDDPEKTAEAFRGGWF--------HSGDLGVMDEEGYITVVDRKKD 419

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  379 QVKLRGQRLELGEVEAALAAAPGVLHAA--------------AAVVDGPGgqqlvgylapADVDVDTVAATTAELLPEYM 444
Cdd:PRK08316   420 MIKTGGENVASREVEEALYTHPAVAEVAviglpdpkwieavtAVVVPKAG----------ATVTEDELIAHCRARLAGFK 489

                          490       500
                   ....*....|....*....|....
gi 1827387616  445 RPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK08316   490 VPKRVIFVDELPRNPSGKILKREL 513

Condensation

pfam00668

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

1749-2069

2.05e-32

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 133.61 E-value: 2.05e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1749 GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPE---ATTTRRIAHLLAGQvhARAREVDYWLEQL-- 1823
Cdd:pfam00668  127 AENRHHLLLSMHHIIVDGVSLGILLRDLADLYQQLLKGEPLPLPPKtpyKDYAEWLQQYLQSE--DYQKDAAYWLEQLeg 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1824 PERPTSFGTSADRPLHRRRDESSLTYVVDDVAGSILTTVPQAFGSSVDDVLLGALARAVRAWqldNGiadGGPVTVSTEG 1903
Cdd:pfam00668  205 ELPVLQLPKDYARPADRSFKGDRLSFTLDEDTEELLRKLAKAHGTTLNDVLLAAYGLLLSRY---TG---QDDIVVGTPG 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1904 HGRDESiagdegaiDLSRTVGWFTSITPLAVDAS-----SDVVHAVKsaKDARLSRPAGGVGFGILRYNSD--GEIAHRP 1976
Cdd:pfam00668  279 SGRPSP--------DIERMVGMFVNTLPLRIDPKggktfSELIKRVQ--EDLLSAEPHQGYPFGDLVNDLRlpRDLSRHP 348

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1977 LPTIMYNY--FGGGTAPSTETAPDDFlpvsdrpnmPSSITGAMRSPSVFGINIsTAGREERRLEAKVTYATDALDEAAAS 2054
Cdd:pfam00668  349 LFDPMFSFqnYLGQDSQEEEFQLSEL---------DLSVSSVIEEEAKYDLSL-TASERGGGLTIKIDYNTSLFDEETIE 418

                          330
                   ....*....|....*
gi 1827387616 2055 DIARRWHDELRAVVE 2069
Cdd:pfam00668  419 RFAEHFKELLEQAIA 433

PRK13391

acyl-CoA synthetase; Provisional

1047-1535

2.19e-32

acyl-CoA synthetase; Provisional

Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 134.82 E-value: 2.19e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1047 DLDPDHPALIC--DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADR 1124
Cdd:PRK13391     8 QTTPDKPAVIMasTGEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPAE 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1125 IAYMLEDSGATVGITDASTR--ARLGESSCE----------------WVDLAdlEAEAESGDDITDTERNGSVrltnlay 1186
Cdd:PRK13391    88 AAYIVDDSGARALITSAAKLdvARALLKQCPgvrhrlvldgdgelegFVGYA--EAVAGLPATPIADESLGTD------- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1187 LIYTSGSTGRPKAV-------GVSH-TGIVDFVNSLAKITTGTPEDEPDTriLHVASPSFdASMFemawAIPAGHTLVIA 1258
Cdd:PRK13391   159 MLYSSGTTGRPKGIkrplpeqPPDTpLPLTAFLQRLWGFRSDMVYLSPAP--LYHSAPQR-AVML----VIRLGGTVIVM 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1259 PQADfAGDALATVlERDEVTDMIITPS----VLATVDPERAQY-VRNLATGGEA---CPPELVER----WserGRRIFNC 1326
Cdd:PRK13391   232 EHFD-AEQYLALI-EEYGVTHTQLVPTmfsrMLKLPEEVRDKYdLSSLEVAIHAaapCPPQVKEQmidwW---GPIIHEY 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1327 YGPTEAT-VWATRSRMTAGKPVTIGKPVDGfTVRVLDGRLHEVPQGVVGELYLSTaGLARGYLGRPGQTAVSFVADPfge 1405
Cdd:PRK13391   307 YAATEGLgFTACDSEEWLAHPGTVGRAMFG-DLHILDDDGAELPPGEPGTIWFEG-GRPFEYLNDPAKTAEARHPDG--- 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1406 pgaRMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKP 1485
Cdd:PRK13391   382 ---TWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLGE---EVKAVVQPVD 455

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 1486 G--ATIDSAAVLDE-AAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHA 1535
Cdd:PRK13391   456 GvdPGPALAAELIAfCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLRDRYW 508

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

114-470

4.24e-32

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 138.13 E-value: 4.24e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  114 FAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPI--TFDVSVrEIFLPIAIGATLV 191
Cdd:PRK08633   775 YGPTFKPDDTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNLRNDDVILSSLPFfhSFGLTV-TLWLPLLEGIKVV 853

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  192 IaepgrHGDP---VHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQ 268
Cdd:PRK08633   854 Y-----HPDPtdaLGIAKLVAKHRATILLGTPTFLRLYLRNKKLHPLMFASLRLVVAGAEKLKPEVADAFEEKF-GIRIL 927

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  269 NQYGPAEASIVVTI----HRVTQDDRVI-----PIGTPTRRVSARVLDA-ALREVPIGVPGELYLGGVQLARGYAGRPDL 338
Cdd:PRK08633   928 EGYGATETSPVASVnlpdVLAADFKRQTgskegSVGMPLPGVAVRIVDPeTFEELPPGEDGLILIGGPQVMKGYLGDPEK 1007

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  339 TAErFVADPfgePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA---PGVLHAAAAVVDGPGG 415
Cdd:PRK08633  1008 TAE-VIKDI---DGIGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEELAKAlggEEVVFAVTAVPDEKKG 1083

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616  416 QQLVGYLAPADVDVDTVAATTAEL-LPEYMRPSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK08633  1084 EKLVVLHTCGAEDVEELKRAIKESgLPNLWKPSRYFKVEALPLLGSGKLDLKGLKE 1139

A_NRPS_TubE_like

cd05906

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...

13-465

5.29e-32

Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 134.33 E-value: 5.29e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   13 LARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPL----DEQLPVDRAR--YMVRTAGVRLVVVTSDG---- 82
Cdd:cd05906     52 LAAGLRQLGLRPGDSVILQFDDNEDFIPAFWACVLAGFVPAPLtvppTYDEPNARLRklRHIWQLLGSPVVLTDAElvae 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   83 --EAEARSRFDDIvDVHVLDISSPGDADLDeeefAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd05906    132 faGLETLSGLPGI-RVLSIEELLDTAADHD----LPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNGLT 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREIFL-PIAIGATLV-IAEPGRHGDPVHLADLIRRHGVTvIHFVP----AMLAAFNEVLGAGV 234
Cdd:cd05906    207 PQDVFLNWVPLDHVGGLVELHLrAVYLGCQQVhVPTEEILADPLRWLDLIDRYRVT-ITWAPnfafALLNDLLEEIEDGT 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  235 GELTSLRLIQTGGEALTPPVARDLMVRL-----PGTRLQNQYGPAEASIVVTIHRV------TQDDRVIPIGTPTRRVSA 303
Cdd:cd05906    286 WDLSSLRYLVNAGEAVVAKTIRRLLRLLepyglPPDAIRPAFGMTETCSGVIYSRSfptydhSQALEFVSLGRPIPGVSM 365

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  304 RVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRArWNRDGEIEYLGRTDFQVKLR 383
Cdd:cd05906    366 RIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEAFTEDGW-------FRTGDLG-FLDNGNLTITGRTKDTIIVN 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  384 GQRLELGEVEAALAAAPGVLH---AAAAVVDGPGG-QQLVGYLAPADVDVDTVAATTAE----------LLPEYMRPsaw 449
Cdd:cd05906    438 GVNYYSHEIEAAVEEVPGVEPsftAAFAVRDPGAEtEELAIFFVPEYDLQDALSETLRAirsvvsrevgVSPAYLIP--- 514

                          490
                   ....*....|....*.
gi 1827387616  450 VRLDAMPLSRSGKVDR 465
Cdd:cd05906    515 LPKEEIPKTSLGKIQR 530

23DHB-AMP_lg

cd05920

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...

1038-1530

8.54e-32

Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 132.45 E-value: 8.54e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPV 1116
Cdd:cd05920     16 PLGDLLARSaARHPDRIAVVDGDRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVPVLA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1117 DPAYPADRIAYMLEDSGATvgitdastrARLGESSCEWVDLADLEAE-AESGDDItdterngsvrltnlAYLIYTSGSTG 1195
Cdd:cd05920     96 LPSHRRSELSAFCAHAEAV---------AYIVPDRHAGFDHRALARElAESIPEV--------------ALFLLSGGTTG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1196 RPKAVGVSHTGIVDFVNSLAKITTGTPedepDTRILHV--ASPSFDASMFEMAWAIPAGHTLVIAPQADfAGDALAtVLE 1273
Cdd:cd05920    153 TPKLIPRTHNDYAYNVRASAEVCGLDQ----DTVYLAVlpAAHNFPLACPGVLGTLLAGGRVVLAPDPS-PDAAFP-LIE 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1274 RDEVTDMIITPSVLATVDPERAQYVRNLAT------GGEACPPELVERWSER-GRRIFNCYGPTEATVWATR-------S 1339
Cdd:cd05920    227 REGVTVTALVPALVSLWLDAAASRRADLSSlrllqvGGARLSPALARRVPPVlGCTLQQVFGMAEGLLNYTRlddpdevI 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1340 RMTAGKPVTigkPVDgfTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRV 1419
Cdd:cd05920    307 IHTQGRPMS---PDD--EIRVVDEEGNPVPPGEEGELLTRGPYTIRGYYRAPEHNARAFTPDGF-------YRTGDLVRR 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1420 AKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGA--TIDSAAVLDE 1497
Cdd:cd05920    375 TPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVVAMPDELLGER---SCAFVVLRDPPpsAAQLRRFLRE 451

                          490       500       510
                   ....*....|....*....|....*....|...
gi 1827387616 1498 AAqhLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05920    452 RG--LAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482

FACL_like_5

cd05924

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1186-1526

1.02e-31

Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 129.42 E-value: 1.02e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1186 YLIYTSGSTGRPKAVGVSHTGIvdFVNSLAKITTGTPEDEPDTRILHVASPSFDASMFEM-----------AWAIPAGHT 1254
Cdd:cd05924      7 YILYTGGTTGMPKGVMWRQEDI--FRMLMGGADFGTGEFTPSEDAHKAAAAAAGTVMFPApplmhgtgswtAFGGLLGGQ 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1255 LVIAPQADFAGDALATVLERDEVTDMIITPSVLAT--VDPERAQYVRNL------ATGGEACPPELVERWSER--GRRIF 1324
Cdd:cd05924     85 TVVLPDDRFDPEEVWRTIEKHKVTSMTIVGDAMARplIDALRDAGPYDLsslfaiSSGGALLSPEVKQGLLELvpNITLV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1325 NCYGPTEATvwATRSRMTAGKPVTIGK--PVDGFTVrVLDGRLHEVPQGVVGELYLSTAGL-ARGYLGRPGQTAVSFV-A 1400
Cdd:cd05924    165 DAFGSSETG--FTGSGHSAGSGPETGPftRANPDTV-VLDDDGRVVPPGSGGVGWIARRGHiPLGYYGDEAKTAETFPeV 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1401 DpfgepGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAY 1480
Cdd:cd05924    242 D-----GVRYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQ---EVVAV 313

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616 1481 LVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:cd05924    314 VQLREGAGVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGKAD 359

ttLC_FACS_AlkK_like

cd12119

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...

4-468

1.54e-31

Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 132.37 E-value: 1.54e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:cd12119     29 AEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFVDRDFL 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 ---AEARSRFDDIVDVHVLDISSPGDADLDE-----EEFAGPTRPA---------NAAFTLFTSGSTGRPKAVVITHR-- 144
Cdd:cd12119    109 pllEAIAPRLPTVEHVVVMTDDAAMPEPAGVgvlayEELLAAESPEydwpdfdenTAAAICYTSGTTGNPKGVVYSHRsl 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  145 -----GIANRLAADIEQydltaRDVFLykaPITfdvsvrEIF------LPIA---IGATLVIaePGRHGDPVHLADLIRR 210
Cdd:cd12119    189 vlhamAALLTDGLGLSE-----SDVVL---PVV------PMFhvnawgLPYAaamVGAKLVL--PGPYLDPASLAELIER 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  211 HGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASIVVTIHRVT---- 286
Cdd:cd12119    253 EGVTFAAGVPTVWQGLLDHLEANGRDLSSLRRVVIGGSAVPRSLIEAFEER--GVRVIHAWGMTETSPLGTVARPPsehs 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  287 ------QDDRVIPIGTPTRRVSARVLDAALREVPI--GVPGELYLGGVQLARGYAGRPDlTAERFVADPFgepgarlYRT 358
Cdd:cd12119    331 nlsedeQLALRAKQGRPVPGVELRIVDDDGRELPWdgKAVGELQVRGPWVTKSYYKNDE-ESEALTEDGW-------LRT 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  359 GDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQ---LVGYLAP-ADVDVDTVAA 434
Cdd:cd12119    403 GDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGErplAVVVLKEgATVTAEELLE 482

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1827387616  435 TTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd12119    483 FLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKAL 516

PRK07788

acyl-CoA synthetase; Validated

4-470

1.95e-31

acyl-CoA synthetase; Validated

Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 132.74 E-value: 1.95e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:PRK07788    78 AELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTGFSGPQLAEVAAREGVKALVYDDEFT 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDIVDVHVL-------DISSPGDADLDE-----EEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLA 151
Cdd:PRK07788   158 DLLSALPPDLGRLRAWggnpdddEPSGSTDETLDDliagsSTAPLPKPPKPGGIVILTSGTTGTPKGAPRPEPSPLAPLA 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  152 ADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLG 231
Cdd:PRK07788   238 GLLSRVPFRAGETTLLPAPMFHATGWAHLTLAMALGSTVVLR---RRFDPEATLEDIAKHKATALVVVPVMLSRILDLGP 314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  232 AGVG--ELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASiVVTIHRvTQDDRVIP--IGTPTRRVSARVLD 307
Cdd:PRK07788   315 EVLAkyDTSSLKIIFVSGSALSPELATRALEAF-GPVLYNLYGSTEVA-FATIAT-PEDLAEAPgtVGRPPKGVTVKILD 391

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  308 AALREVPIGVPGELYLGGVQLARGYAGrpdltaerfVADPFGEPGarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRL 387
Cdd:PRK07788   392 ENGNEVPRGVVGRIFVGNGFPFEGYTD---------GRDKQIIDG--LLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENV 460

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  388 ELGEVEAALAAAPGVLHAAAAVVDGPG-GQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKV 463
Cdd:PRK07788   461 FPAEVEDLLAGHPDVVEAAVIGVDDEEfGQRLRAFVVKapgAALDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKV 540


                   ....*..
gi 1827387616  464 DRRLLPE 470
Cdd:PRK07788   541 LKRELRE 547

PRK12583

acyl-CoA synthetase; Provisional

1023-1532

2.89e-31

acyl-CoA synthetase; Provisional

Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 132.20 E-value: 2.89e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1023 TPGAMVGRGGEVEA------GTLIDVLAQRDldPDHPALIC--DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGME 1094
Cdd:PRK12583     1 MPQPSYYQGGGDKPlltqtiGDAFDATVARF--PDREALVVrhQALRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1095 RSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTR-----------------ARLGESSCE---- 1153
Cdd:PRK12583    79 NCAEWLLTQFATARIGAILVNINPAYRASELEYALGQSGVRWVICADAFKtsdyhamlqellpglaeGQPGALACErlpe 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1154 --WVDL------------ADLEAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITT 1219
Cdd:PRK12583   159 lrGVVSlapapppgflawHELQARGETVSREALAERQASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1220 GTPEDEpdtriLHVASPSFDAsmFEMAWA----IPAGHTLVIaPQADFagDALATV--LERDEVTDMIITPSV-LATVD- 1291
Cdd:PRK12583   239 LTEHDR-----LCVPVPLYHC--FGMVLAnlgcMTVGACLVY-PNEAF--DPLATLqaVEEERCTALYGVPTMfIAELDh 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1292 PERAQY-VRNLATG---GEACPPELVERWSERGR--RIFNCYGPTEATVWATRSrmTAGKPV-----TIGKPVDGFTVRV 1360
Cdd:PRK12583   309 PQRGNFdLSSLRTGimaGAPCPIEVMRRVMDEMHmaEVQIAYGMTETSPVSLQT--TAADDLerrveTVGRTQPHLEVKV 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1361 LDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarMYaTGDLVRVAKGGNLEFAGRADHQVKINGQ 1440
Cdd:PRK12583   387 VDPDGATVPRGEIGELCTRGYSVMKGYWNNPEATAESIDEDGW------MH-TGDLATMDEQGYVRIVGRSKDMIIRGGE 459

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1441 RVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLT 1520
Cdd:PRK12583   460 NIYPREIEEFLFTHPAVADVQVFGVPDEKYGE---EIVAWVRLHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMT 536

                          570
                   ....*....|..
gi 1827387616 1521 PAGKLDRAALPE 1532
Cdd:PRK12583   537 VTGKVQKFRMRE 548

PRK07787

acyl-CoA synthetase; Validated

1-472

4.42e-31

acyl-CoA synthetase; Validated

Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 130.11 E-value: 4.42e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGvgaevAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK07787    26 LSRSDLAGAATAVAERVAGAR-----RVAVLATPTLATVLAVVGALIAGVPVVPVPPDSGVAERRHILADSGAQAWLGPA 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDdiVDVHVLDISSPGDADldeeefagptrPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:PRK07787   101 PDDPAGLPHVP--VRLHARSWHRYPEPD-----------PDAPALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAWQWT 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPItFDVS--VREIFLPIAIGATLViaEPGRHgDPVHLADLIRRHGvTVIHFVPAM---LAAFNEVLGAgvg 235
Cdd:PRK07787   168 ADDVLVHGLPL-FHVHglVLGVLGPLRIGNRFV--HTGRP-TPEAYAQALSEGG-TLYFGVPTVwsrIAADPEAARA--- 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  236 eLTSLRLIQTGGEALTPPVARDLmVRLPGTRLQNQYGPAEASIVVTIhRVTQDDRVIPIGTPTRRVSARVLDAALREVPI 315
Cdd:PRK07787   240 -LRGARLLVSGSAALPVPVFDRL-AALTGHRPVERYGMTETLITLST-RADGERRPGWVGLPLAGVETRLVDEDGGPVPH 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  316 GVP--GELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGR--TDFqVKLRGQRLELGE 391
Cdd:PRK07787   317 DGEtvGELQVRGPTLFDGYLNRPDATAAAFTADGW-------FRTGDVAVVDPDGMHRIVGResTDL-IKSGGYRIGAGE 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  392 VEAALAAAPGVlhAAAAVVDGPG---GQQLVGYLAPA-DVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRL 467
Cdd:PRK07787   389 IETALLGHPGV--REAAVVGVPDddlGQRIVAYVVGAdDVAADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQ 466


                   ....*
gi 1827387616  468 LPEPE 472
Cdd:PRK07787   467 LLSEG 471

MACS_like_4

cd05969

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...

4-468

4.62e-31

Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 129.54 E-value: 4.62e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTsdge 83
Cdd:cd05969      4 AQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLITT---- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aearsrfddivdvhvldisspgdadldeEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05969     80 ----------------------------EELYERTDPEDPTLLHYTSGTTGTPKGVLHVHDAMIFYYFTGKYVLDLHPDD 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKA-PITFDVSVREIFLPIAIGATLVIAEpGRHgDPVHLADLIRRHGVTVIHFVPAmlaAFNEVLGAGVG-----EL 237
Cdd:cd05969    132 IYWCTAdPGWVTGTVYGIWAPWLNGVTNVVYE-GRF-DAESWYGIIERVKVTVWYTAPT---AIRMLMKEGDElarkyDL 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  238 TSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGV 317
Cdd:cd05969    207 SSLRFIHSVGEPLNPEAIRWGMEVF-GVPIHDTWWQTETGSIMIANYPCMPIKPGSMGKPLPGVKAAVVDENGNELPPGT 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYL--GGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:cd05969    286 KGILALkpGWPSMFRGIWNDEERYKNSFIDG--------WYLTGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPFEVESA 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  396 LAAAPGVlhAAAAVVDGPG---GQQLVGYLA------PADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRR 466
Cdd:cd05969    358 LMEHPAV--AEAGVIGKPDplrGEIIKAFISlkegfePSDELKEEIINFVRQKLGAHVAPREIEFVDNLPKTRSGKIMRR 435


                   ..
gi 1827387616  467 LL 468
Cdd:cd05969    436 VL 437

PRK07786

long-chain-fatty-acid--CoA ligase; Validated

1050-1540

7.19e-31

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 130.67 E-value: 7.19e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK07786    31 PDAPALRFLGNTTTWRELDDRVAALAGALSRRGVGFGDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLTPPEIAFLV 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAS-----TRARL------------GESSCEWVDLADLEAEAESGDDITDTERNGSvrltnlAYLIYTSG 1192
Cdd:PRK07786   111 SDCGAHVVVTEAAlapvaTAVRDivpllstvvvagGSSDDSVLGYEDLLAEAGPAHAPVDIPNDSP------ALIMYTSG 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1193 STGRPKAVGVSHTGIVDfvNSLAKITTGTPEDEPDtrILHVASPSFD-ASMFEMAWAIPAGHTLVIAPQADFAGDALATV 1271
Cdd:PRK07786   185 TTGRPKGAVLTHANLTG--QAMTCLRTNGADINSD--VGFVGVPLFHiAGIGSMLPGLLLGAPTVIYPLGAFDPGQLLDV 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1272 LERDEVTDMIITP----SVLA--TVDPeRAQYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATvwaTRSRMTA 1343
Cdd:PRK07786   261 LEAEKVTGIFLVPaqwqAVCAeqQARP-RDLALRVLSWGAAPASDTLLRQMAATfpEAQILAAFGQTEMS---PVTCMLL 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 GKPV-----TIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVR 1418
Cdd:PRK07786   337 GEDAirklgSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGGWF--------HSGDLVR 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1419 VAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGvestRGGRKHTEV-VAYLVAKPGATIDSAAVLDE 1497
Cdd:PRK07786   409 QDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIG----RADEKWGEVpVAVAAVRNDDAALTLEDLAE 484

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 1498 -AAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPH-APEPAE 1540
Cdd:PRK07786   485 fLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRERYgACVNVE 529

ABCL

cd05958

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...

1053-1530

7.38e-31

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.

Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 128.75 E-value: 7.38e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1053 PALICDGTEMDYDEFETRTNAIARALLARGVS-PEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLED 1131
Cdd:cd05958      2 TCLRSPEREWTYRDLLALANRIANVLVGELGIvPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYILDK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1132 SGATVGITDASTRARlgesscewvdladleaeaesgDDItdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFV 1211
Cdd:cd05958     82 ARITVALCAHALTAS---------------------DDI--------------CILAFTSGTTGAPKATMHFHRDPLASA 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1212 NSLAKITTGTpedEPDTRILHVASPSFDASMFEMA-WAIPAGHTLVIAPQAdfAGDALATVLERDEVTDMIITPSVLATV 1290
Cdd:cd05958    127 DRYAVNVLRL---REDDRFVGSPPLAFTFGLGGVLlFPFGVGASGVLLEEA--TPDLLLSAIARYKPTVLFTAPTAYRAM 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1291 --DPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDG 1363
Cdd:cd05958    202 laHPDAAGPdlssLRKCVSAGEALPAALHRAWKEAtGIPIIDGIGSTEMFHIFISARPGDARPGATGKPVPGYEAKVVDD 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1364 RLHEVPQGVVGELYLStaglargylgrpGQTAVSFVADPfgepGARMY------ATGDLVRVAKGGNLEFAGRADHQVKI 1437
Cdd:cd05958    282 EGNPVPDGTIGRLAVR------------GPTGCRYLADK----RQRTYvqggwnITGDTYSRDPDGYFRHQGRSDDMIVS 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1438 NGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSA---AVLDEAAQHLAAHMVPSQAIVI 1514
Cdd:cd05958    346 GGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVV---VKAFVVLRPGVIPGPVlarELQDHAKAHIAPYKYPRAIEFV 422

                          490
                   ....*....|....*.
gi 1827387616 1515 DEIPLTPAGKLDRAAL 1530
Cdd:cd05958    423 TELPRTATGKLQRFAL 438

PRK06087

medium-chain fatty-acid--CoA ligase;

1038-1530

7.49e-31

medium-chain fatty-acid--CoA ligase;

Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 130.64 E-value: 7.49e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQR-DLDPDHPALICD-GTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVP 1115
Cdd:PRK06087    24 SLADYWQQTaRAMPDKIAVVDNhGASYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSVP 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1116 VDPAYPADRIAYMLEDSGATVGITDASTRARLGES----------SCEWVDLADLEAEAESGDDITDTERNG-------S 1178
Cdd:PRK06087   104 LLPSWREAELVWVLNKCQAKMFFAPTLFKQTRPVDlilplqnqlpQLQQIVGVDKLAPATSSLSLSQIIADYeplttaiT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1179 VRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSFDASMFEMAWAIP--AGHTLV 1256
Cdd:PRK06087   184 THGDELAAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQD-----VFMMPAPLGHATGFLHGVTAPflIGARSV 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1257 IapQADFAGDALATVLERDEVTDMI-ITPSV---LATV--DPERAQYVRNLATGGEACPPELVERWSERGRRIFNCYGPT 1330
Cdd:PRK06087   259 L--LDIFTPDACLALLEQQRCTCMLgATPFIydlLNLLekQPADLSALRFFLCGGTTIPKKVARECQQRGIKLLSVYGST 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1331 EATVWA------TRSRMTAgkpvTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFg 1404
Cdd:PRK06087   337 ESSPHAvvnlddPLSRFMH----TDGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLDEPELTARALDEEGW- 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1405 epgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAK 1484
Cdd:PRK06087   412 ------YYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGER---SCAYVVLK 482

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616 1485 PGATIDSAAVLDE--AAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK06087   483 APHHSLTLEEVVAffSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLL 530

AAS_C

cd05909

C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...

1058-1526

9.06e-31

Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 129.37 E-value: 9.06e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1058 DGTEMDYDEFETRTNAIARaLLARGVSPEDVVAVGMERSIGSVLATWGVIKSGaaYVPVDPAYPA--DRIAYMLEDSGAT 1135
Cdd:cd05909      4 LGTSLTYRKLLTGAIALAR-KLAKMTKEGENVGVMLPPSAGGALANFALALSG--KVPVMLNYTAglRELRACIKLAGIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1136 VGITD-------ASTRARLGESSCEWVDLADLEAEAESGDDI----------TDTERN---GSVRLTNLAYLIYTSGSTG 1195
Cdd:cd05909     81 TVLTSkqfieklKLHHLFDVEYDARIVYLEDLRAKISKADKCkaflagkfppKWLLRIfgvAPVQPDDPAVILFTSGSEG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1196 RPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSFDASMFEMAWAIP--AGHTLVIAPQ-------ADFAGD 1266
Cdd:cd05909    161 LPKGVVLSHKNLLANVEQITAIFDPNPED-----VVFGALPFFHSFGLTGCLWLPllSGIKVVFHPNpldykkiPELIYD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1267 ALATVLerdevtdmIITPSVLA----TVDPERAQYVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEAT-VWATRSR 1340
Cdd:cd05909    236 KKATIL--------LGTPTFLRgyarAAHPEDFSSLRLVVAGAEKLKDTLRQEFQEKfGIRILEGYGTTECSpVISVNTP 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1341 MTAGKPVTIGKPVDGFTVRVLDGRLH-EVPQGVVGELYLSTAGLARGYLGRPGQTAVsfvadpfgEPGARMYATGDLVRV 1419
Cdd:cd05909    308 QSPNKEGTVGRPLPGMEVKIVSVETHeEVPIGEGGLLLVRGPNVMLGYLNEPELTSF--------AFGDGWYDTGDIGKI 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1420 AKGGNLEFAGRADHQVKINGQRVELGEIE-AVLDAQPGVAQSVVVGVESTRGGrkhtEVVAYLVAKPGATIDSaavLDEA 1498
Cdd:cd05909    380 DGEGFLTITGRLSRFAKIAGEMVSLEAIEdILSEILPEDNEVAVVSVPDGRKG----EKIVLLTTTTDTDPSS---LNDI 452

                          490       500       510
                   ....*....|....*....|....*....|
gi 1827387616 1499 AQH--LAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:cd05909    453 LKNagISNLAKPSYIHQVEEIPLLGTGKPD 482

PRK07787

acyl-CoA synthetase; Validated

2567-3063

1.10e-30

acyl-CoA synthetase; Validated

Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 128.95 E-value: 1.10e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2567 LAELFRAAARRAPDHVAVVDGAGARLTYRELDEASDRLARwligrGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:PRK07787     1 LASLNPAAVAAAADIADAVRIGGRVLSRSDLAGAATAVAE-----RVAGARRVAVLATPTLATVLAVVGALIAGVPVVPV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDY-PAERvASMIEDSGAVLGLsvlasGDLPGQefewmrldddsvAAEIAAVPAGPITD-AERLGEVTAANLAYVIYTS 2724
Cdd:PRK07787    76 PPDSgVAER-RHILADSGAQAWL-----GPAPDD------------PAGLPHVPVRLHARsWHRYPEPDPDAPALIVYTS 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2725 GSTGRPKGVAVTHSGLANF--ARQESDRLNAGDnpvVLGFASPSFDAS--VLEYLLATVNEGTLAY--RPS-EAVGGEVl 2797
Cdd:PRK07787   138 GTTGPPKGVVLSRRAIAADldALAEAWQWTADD---VLVHGLPLFHVHglVLGVLGPLRIGNRFVHtgRPTpEAYAQAL- 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2798 erfiaEHGATHTFLTPSVLSTM--DPTAVPSL---RVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTET--TIGITISS 2868
Cdd:PRK07787   214 -----SEGGTLYFGVPTVWSRIaaDPEAARALrgaRLLVSGSAALPVPVFDRLAALTghRPVERYGMTETliTLSTRADG 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2869 AMRPGdpvRLGGPIGGVDLMVLDERLRPVPVGMP--GELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVV 2946
Cdd:PRK07787   289 ERRPG---WVGLPLAGVETRLVDEDGGPVPHDGEtvGELQVRGPTLFDGYLNRPDATAAAFTADGW-------FRTGDVA 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2947 RWTPDTDtggltLEYTGR-SDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYIVPVDGAVEvSELK 3024
Cdd:PRK07787   359 VVDPDGM-----HRIVGReSTDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDdLGQRIVAYVVGADDVAA-DELI 432

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1827387616 3025 AFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPV 3063
Cdd:PRK07787   433 DFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLLSEG 471

A_NRPS_alphaAR

cd17647

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ...

1060-1533

2.17e-30

Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 128.79 E-value: 2.17e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1060 TEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRiaymledsgATVGIT 1139
Cdd:cd17647     19 RSFTYRDINEASNIVAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPPAR---------QNIYLG 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DASTRARLGesscewvdLADleAEAESGDDITDTerngsvrltnlayLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKiTT 1219
Cdd:cd17647     90 VAKPRGLIV--------IRA--AGVVVGPDSNPT-------------LSFTSGSEGIPKGVLGRHFSLAYYFPWMAK-RF 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1220 GTPEDEPDTRILHVASPSFDASMFEmawAIPAGHTLVIaPQADFAG--DALATVLERDEVTDMIITPSV--LATVDP--- 1292
Cdd:cd17647    146 NLSENDKFTMLSGIAHDPIQRDMFT---PLFLGAQLLV-PTQDDIGtpGRLAEWMAKYGATVTHLTPAMgqLLTAQAttp 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1293 ----ERAQYV---------RNLATGGEACppelverwsergrRIFNCYGPTEA----TVWATRSR-------------MT 1342
Cdd:cd17647    222 fpklHHAFFVgdiltkrdcLRLQTLAENV-------------RIVNMYGTTETqravSYFEVPSRssdptflknlkdvMP 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1343 AGKPVtigKPVDGFTVRVLDgRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGA-------------- 1408
Cdd:cd17647    289 AGRGM---LNVQLLVVNRND-RTQICGIGEVGEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEPDHwnyldkdnnepwrq 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1409 -------RMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVgVESTRGGRKhtEVVAYL 1481
Cdd:cd17647    365 fwlgprdRLYRTGDLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITL-VRRDKDEEP--TLVSYI 441

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1482 VAKP-----------------------GATIDSAAVLDEAAQH----LAAHMVPSQAIVIDEIPLTPAGKLDRAALPEP 1533
Cdd:cd17647    442 VPRFdkpddesfaqedvpkevstdpivKGLIGYRKLIKDIREFlkkrLASYAIPSLIVVLDKLPLNPNGKVDKPKLQFP 520

MACS_like_4

cd05969

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...

2592-3059

2.73e-30

Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 127.23 E-value: 2.73e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAvlglsvl 2671
Cdd:cd05969      1 YTFAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEA------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrldddsvaaeiaavpAGPITDAERLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRL 2751
Cdd:cd05969     74 ----------------------------KVLITTEELYERTDPEDPTLLHYTSGTTGTPKGVLHVHDAMIFYYFTGKYVL 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLSTMDPTAV------- 2824
Cdd:cd05969    126 DLHPDDIYWCTADPGWVTGTVYGIWAPWLNGVTNVVYEGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEGDelarkyd 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2825 -PSLRVIAAGGEAVpQPIVDRW---APATELHNLYGPTETTigiTISSAMRPGDPVR---LGGPIGGVDLMVLDERLRPV 2897
Cdd:cd05969    206 lSSLRFIHSVGEPL-NPEAIRWgmeVFGVPIHDTWWQTETG---SIMIANYPCMPIKpgsMGKPLPGVKAAVVDENGNEL 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2898 PVGMPGELYVAGG--ALSRGYLDRSGLTAERFTaNPYGTAGQRMYRTGDVVRWtpdtdtggltleYTGRSDDQVKLRGLR 2975
Cdd:cd05969    282 PPGTKGILALKPGwpSMFRGIWNDEERYKNSFI-DGWYLTGDLAYRDEDGYFW------------FVGRADDIIKTSGHR 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2976 IELGEIEAVLAEHDAVESAVVLGVGGSV-ATALAAYIVPVDGAVEVSELK----AFAGGRLPAYMVPSSFTVIDELPLTP 3050
Cdd:cd05969    349 VGPFEVESALMEHPAVAEAGVIGKPDPLrGEIIKAFISLKEGFEPSDELKeeiiNFVRQKLGAHVAPREIEFVDNLPKTR 428


                   ....*....
gi 1827387616 3051 VGKLDKRAL 3059
Cdd:cd05969    429 SGKIMRRVL 437

PRK07470

acyl-CoA synthetase; Validated

1044-1532

2.79e-30

acyl-CoA synthetase; Validated

Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 128.62 E-value: 2.79e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1044 AQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:PRK07470    17 ARRF--PDRIALVWGDRSWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVPTNFRQTPD 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGI--------TDASTRARLGESSCEWVDLADLEA--EAESGDDITDTERNGSVRLTNLAYLIYTSGS 1193
Cdd:PRK07470    95 EVAYLAEASGARAMIchadfpehAAAVRAASPDLTHVVAIGGARAGLdyEALVARHLGARVANAAVDHDDPCWFFFTSGT 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1194 TGRPKAVGVSHtGIVDFV--NSLAKITTGTPEDEpdtRILHVASPSFDASMFEMAwAIPAGHTLVIAPQADFAGDALATV 1271
Cdd:PRK07470   175 TGRPKAAVLTH-GQMAFVitNHLADLMPGTTEQD---ASLVVAPLSHGAGIHQLC-QVARGAATVLLPSERFDPAEVWAL 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1272 LERDEVTDMIITPSVLA--TVDPERAQY----VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATvwatrSRMTAG 1344
Cdd:PRK07470   250 VERHRVTNLFTVPTILKmlVEHPAVDRYdhssLRYVIYAGAPMYRADQKRALAKlGKVLVQYFGLGEVT-----GNITVL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 KPV-------------TIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmy 1411
Cdd:PRK07470   325 PPAlhdaedgpdarigTCGFERTGMEVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNPEANAKAFRDGWF-------- 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1412 ATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATID 1490
Cdd:PRK07470   397 RTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVLGVPDPVWG----EVgVAVCVARDGAPVD 472

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1827387616 1491 SAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK07470   473 EAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVRE 514

ttLC_FACS_AEE21_like

cd12118

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...

1050-1524

4.36e-30

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.

Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 127.42 E-value: 4.36e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:cd12118     18 PDRTSIVYGDRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLDAEEIAFIL 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDAS--TRARL--GESSCEWVDLADlEAEAesgddITdterngsvrltnlayLIYTSGSTGRPKAVGVSHT 1205
Cdd:cd12118     98 RHSEAKVLFVDREfeYEDLLaeGDPDFEWIPPAD-EWDP-----IA---------------LNYTSGTTGRPKGVVYHHR 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1206 GIvdFVNSLAKITTGtpEDEPDTRILHVAsPSFDASMFEMAWAIPA-GHTLVIAPQADfaGDALATVLERDEVTDMIITP 1284
Cdd:cd12118    157 GA--YLNALANILEW--EMKQHPVYLWTL-PMFHCNGWCFPWTVAAvGGTNVCLRKVD--AKAIYDLIEKHKVTHFCGAP 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1285 SVLATVDPERAQYVRNL------ATGGEACPPELVERWSERGRRIFNCYGPTE----ATV------WAT-----RSRMTA 1343
Cdd:cd12118    230 TVLNMLANAPPSDARPLphrvhvMTAGAPPPAAVLAKMEELGFDVTHVYGLTEtygpATVcawkpeWDElpteeRARLKA 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 GKPVTIgkpVDGFTVRVLD-GRLHEVPQ-GV-VGELYLSTAGLARGYLGRPGQTAVSFvadpfgEPGarMYATGDLVRVA 1420
Cdd:cd12118    310 RQGVRY---VGLEEVDVLDpETMKPVPRdGKtIGEIVFRGNIVMKGYLKNPEATAEAF------RGG--WFHSGDLAVIH 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1421 KGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEAA 1499
Cdd:cd12118    379 PDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAAVVARPDEKWG----EVpCAFVELKEGAKVTEEEIIAFCR 454

                          490       500
                   ....*....|....*....|....*
gi 1827387616 1500 QHLAAHMVPSQaIVIDEIPLTPAGK 1524
Cdd:cd12118    455 EHLAGFMVPKT-VVFGELPKTSTGK 478

PRK03640

o-succinylbenzoate--CoA ligase;

1043-1527

6.34e-30

o-succinylbenzoate--CoA ligase;

Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 127.00 E-value: 6.34e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1043 LAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYP 1121
Cdd:PRK03640     8 LKQRaFLTPDRTAIEFEEKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1122 ADRIAYMLEDSGATVGITDASTRARLGESSCewVDLADLEAEAESGDDITDTerngsVRLTNLAYLIYTSGSTGRPKavG 1201
Cdd:PRK03640    88 REELLWQLDDAEVKCLITDDDFEAKLIPGIS--VKFAELMNGPKEEAEIQEE-----FDLDEVATIMYTSGTTGKPK--G 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1202 VSHTgivdFVNSLAK-----ITTGTPEDEpdtRILhVASPSFDASMFE-MAWAIPAGHTLVIAPQadFAGDALATVLERD 1275
Cdd:PRK03640   159 VIQT----YGNHWWSavgsaLNLGLTEDD---CWL-AAVPIFHISGLSiLMRSVIYGMRVVLVEK--FDAEKINKLLQTG 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1276 EVTDMIITPSVLATV--DPERAQY---VRNLATGGEACPPELVERWSERGRRIFNCYGPTEatvwaTRSRMTAGKPVTI- 1349
Cdd:PRK03640   229 GVTIISVVSTMLQRLleRLGEGTYpssFRCMLLGGGPAPKPLLEQCKEKGIPVYQSYGMTE-----TASQIVTLSPEDAl 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1350 ------GKPVDGFTVRVLDGrLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGG 1423
Cdd:PRK03640   304 tklgsaGKPLFPCELKIEKD-GVVVPPFEEGEIVVKGPNVTKGYLNREDATRETFQDGWF--------KTGDIGYLDEEG 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1424 NLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAkpGATIDSAAVLDEAAQHL 1502
Cdd:PRK03640   375 FLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWG----QVpVAFVVK--SGEVTEEELRHFCEEKL 448

                          490       500
                   ....*....|....*....|....*
gi 1827387616 1503 AAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:PRK03640   449 AKYKVPKRFYFVEELPRNASGKLLR 473

BCL_like

cd05919

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...

1-465

1.22e-29

Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 125.27 E-value: 1.22e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:cd05919     11 VTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDCEARLVVTSA 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DgeaearsrfddivdvhvldisspgdadldeeefagptrpaNAAFTLFTSGSTGRPKAVVITHR---GIANRLAADIeqY 157
Cdd:cd05919     91 D----------------------------------------DIAYLLYSSGTTGPPKGVMHAHRdplLFADAMAREA--L 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  158 DLTARDVFLYKAPITFDVSV-REIFLPIAIGATLVIAePGRHgDPVHLADLIRRHGVTVIHFVPAMLAAfneVLGAGVGE 236
Cdd:cd05919    129 GLTPGDRVFSSAKMFFGYGLgNSLWFPLAVGASAVLN-PGWP-TAERVLATLARFRPTVLYGVPTFYAN---LLDSCAGS 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 ---LTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRVTQddrvIPIGTPTRRV---SARVLDAAL 310
Cdd:cd05919    204 pdaLRSLRLCVSAGEALPRGLGERWMEHF-GGPILDGIGATEVGHIFLSNRPGA----WRLGSTGRPVpgyEIRLVDEEG 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  311 REVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELG 390
Cdd:cd05919    279 HTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFNGG--------WYRTGDKFCRDADGWYTHAGRADDMLKVGGQWVSPV 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  391 EVEAALAAAPGVLHAA-AAVVDGPGGQQLVGYLAPADVDVDTVA------ATTAELLPEYMRPSAWVRLDAMPLSRSGKV 463
Cdd:cd05919    351 EVESLIIQHPAVAEAAvVAVPESTGLSRLTAFVVLKSPAAPQESlardihRHLLERLSAHKVPRRIAFVDELPRTATGKL 430


                   ..
gi 1827387616  464 DR 465
Cdd:cd05919    431 QR 432

benz_CoA_lig

TIGR02262

benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ...

1-470

1.44e-29

benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.

Pssm-ID: 274059 [Multi-domain] Cd Length: 505 Bit Score: 126.11 E-value: 1.44e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:TIGR02262   31 LSYGELEAQVRRLAAALRRLGVKREERVLLLMLDGVDFPIAFLGAIRAGIVPVALNTLLTADDYAYMLEDSRARVVFVSG 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGE---AEARSRFDDIVDVHVLDISSPGDADLDEE-------EFAGPTRPANAAFTLFTSGSTGRPKAVVITHrgianrl 150
Cdd:TIGR02262  111 ALLpviKAALGKSPHLEHRVVVGRPEAGEVQLAELlateseqFKPAATQADDPAFWLYSSGSTGMPKGVVHTH------- 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  151 AADIEQYDLTAR--------DVFLYKAPITFDVSV-REIFLPIAIGATLVIAepGRHGDPVHLADLIRRHGVTVIHFVP- 220
Cdd:TIGR02262  184 SNPYWTAELYARntlgiredDVCFSAAKLFFAYGLgNALTFPMSVGATTVLM--GERPTPDAVFDRLRRHQPTIFYGVPt 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  221 ---AMLAAFNEVLGAGVgeltSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEAsIVVTIHRVTQDDRVIPIGTP 297
Cdd:TIGR02262  262 lyaAMLADPNLPSEDQV----RLRLCTSAGEALPAEVGQRWQARF-GVDIVDGIGSTEM-LHIFLSNLPGDVRYGTSGKP 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  298 TRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTD 377
Cdd:TIGR02262  336 VPGYRLRLVGDGGQDVADGEPGELLISGPSSATMYWNNRAKSRDTFQGE--------WTRSGDKYVRNDDGSYTYAGRTD 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  378 FQVKLRGQRLELGEVEAALAAAPGVLHAA--------------AAVVDGPGGQQLvgylapadvdVDTVAATTAELLPEY 443
Cdd:TIGR02262  408 DMLKVSGIYVSPFEIESALIQHPAVLEAAvvgvadedglikpkAFVVLRPGQTAL----------ETELKEHVKDRLAPY 477

                          490       500
                   ....*....|....*....|....*..
gi 1827387616  444 MRPSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:TIGR02262  478 KYPRWIVFVDDLPKTATGKIQRFKLRE 504

4CL

cd05904

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...

2-468

2.01e-29

Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 125.81 E-value: 2.01e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:cd05904     34 TYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAEIAKQVKDSGAKLAFTTAE 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEARSRFDDIV-----DVHVLDISSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAA--DI 154
Cdd:cd05904    114 LAEKLASLALPVVlldsaEFDSLSFSDLLFEADEAEPPVVVIKQDDVAALLYSSGTTGRSKGVMLTHRNLIAMVAQfvAG 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  155 EQYDLTARDVFLYKAPItFDVSVREIFL--PIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGA 232
Cdd:cd05904    194 EGSNSDSEDVFLCVLPM-FHIYGLSSFAlgLLRLGATVVVM---PRFDLEELLAAIERYKVTHLPVVPPIVLALVKSPIV 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  233 GVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIP--IGTPTRRVSARVLDAAL 310
Cdd:cd05904    270 DKYDLSSLRQIMSGAAPLGKELIEAFRAKFPNVDLGQGYGMTESTGVVAMCFAPEKDRAKYgsVGRLVPNVEAKIVDPET 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  311 REV-PIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLEL 389
Cdd:cd05904    350 GESlPPNQTGELWIRGPSIMKGYLNNPEATAATIDKEGW-------LHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAP 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  390 GEVEAALAAAPGVLHAA--------------AAVVDGPGGQqlvgyLAPADVdVDTVAATTAellpEYMRPSAWVRLDAM 455
Cdd:cd05904    423 AELEALLLSHPEILDAAvipypdeeagevpmAFVVRKPGSS-----LTEDEI-MDFVAKQVA----PYKKVRKVAFVDAI 492

                          490
                   ....*....|...
gi 1827387616  456 PLSRSGKVDRRLL 468
Cdd:cd05904    493 PKSPSGKILRKEL 505

PRK03640

o-succinylbenzoate--CoA ligase;

2575-3059

2.55e-29

o-succinylbenzoate--CoA ligase;

Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 125.07 E-value: 2.55e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAER 2654
Cdd:PRK03640    12 AFLTPDRTAIEFE-EKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2655 VASMIEDSGAVLglsVLASGDLPGQEFEWMRLDddsvaaeIAAVPAGPITDAERLGEVTAANLAYVIYTSGSTGRPKGVA 2734
Cdd:PRK03640    91 LLWQLDDAEVKC---LITDDDFEAKLIPGISVK-------FAELMNGPKEEAEIQEEFDLDEVATIMYTSGTTGKPKGVI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2735 VTHSGlaNFARQESDRLNAG--DNPVVLGfASPSFDASVLEYLLATVNEGTLAYrpseavggeVLERFIAE--HGA--TH 2808
Cdd:PRK03640   161 QTYGN--HWWSAVGSALNLGltEDDCWLA-AVPIFHISGLSILMRSVIYGMRVV---------LVEKFDAEkiNKLlqTG 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2809 TFLTPSVLSTM---------DPTAVPSLRVIAAGGEAVPQPIVDrwapATELHNL-----YGPTETTIGITissAMRPGD 2874
Cdd:PRK03640   229 GVTIISVVSTMlqrllerlgEGTYPSSFRCMLLGGGPAPKPLLE----QCKEKGIpvyqsYGMTETASQIV---TLSPED 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2875 PVR----LGGPIGGVDLMVLDErLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRwtp 2950
Cdd:PRK03640   302 ALTklgsAGKPLFPCELKIEKD-GVVVPPFEEGEIVVKGPNVTKGYLNREDATRETFQDG--------WFKTGDIGY--- 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2951 dTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVAtalAAYIVpVDGAVEVSELKAF 3026
Cdd:PRK03640   370 -LDEEGF-LYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPddkwGQVP---VAFVV-KSGEVTEEELRHF 443

                          490       500       510
                   ....*....|....*....|....*....|...
gi 1827387616 3027 AGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK03640   444 CEEKLAKYKVPKRFYFVEELPRNASGKLLRHEL 476

FACL_like_2

cd05917

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2722-3056

2.62e-29

Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 122.00 E-value: 2.62e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2722 YTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDN-----PVvlgfasPSFDA--SVLEYlLATVNEGTLAYRPSEAVGG 2794
Cdd:cd05917      9 FTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQdrlciPV------PLFHCfgSVLGV-LACLTHGATMVFPSPSFDP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2795 EVLERFIAEHGATHTFLTPS----VLSTMDPTAVP--SLRVIAAGGEAVPQPIVDRWAPA---TELHNLYGPTETTIGIT 2865
Cdd:cd05917     82 LAVLEAIEKEKCTALHGVPTmfiaELEHPDFDKFDlsSLRTGIMAGAPCPPELMKRVIEVmnmKDVTIAYGMTETSPVST 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2866 ISsamRPGDPVRL-----GGPIGGVDLMVLDERLRPVP-VGMPGELYVAGGALSRGYLDRSGLTAERFTanpygtaGQRM 2939
Cdd:cd05917    162 QT---RTDDSIEKrvntvGRIMPHTEAKIVDPEGGIVPpVGVPGELCIRGYSVMKGYWNDPEKTAEAID-------GDGW 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2940 YRTGDVVrwTPDTDTgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GGSVatalAAYIVPV 3014
Cdd:cd05917    232 LHTGDLA--VMDEDG---YCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVpderyGEEV----CAWIRLK 302

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1827387616 3015 DGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd05917    303 EGAeLTEEDIKAYCKGKIAHYKVPRYVFFVDEFPLTVSGKIQK 345

PRK13383

acyl-CoA synthetase; Provisional

1009-1531

3.86e-29

acyl-CoA synthetase; Provisional

Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 125.11 E-value: 3.86e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1009 AARAKSVSAPVSARTPGAMV------GRGGeVEAGTLIDVLAQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARG 1082
Cdd:PRK13383     5 AARALVRSGLLNPPSPRAVLrllreaSRGG-TNPYTLLAVTAARW--PGRTAIIDDDGALSYRELQRATESLARRLTRDG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1083 VSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCEWVDLADLEA 1162
Cdd:PRK13383    82 VAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFRSDALAAALRAHHISTVVADNEFAERIAGADDAVAVIDPATA 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1163 EAESGDDITDTERNGSVrltnlayLIYTSGSTGRPKAVG-----VSHTGIVDFVNSLAKITTGTPedepdtriLHVASPS 1237
Cdd:PRK13383   162 GAEESGGRPAVAAPGRI-------VLLTSGTTGKPKGVPrapqlRSAVGVWVTILDRTRLRTGSR--------ISVAMPM 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1238 FDASMFEM-AWAIPAGHTLVIAPQADFAGDALATVLERDEVtdMIITPSVLATV----DPERAQ----YVRNLATGGEAC 1308
Cdd:PRK13383   227 FHGLGLGMlMLTIALGGTVLTHRHFDAEAALAQASLHRADA--FTAVPVVLARIlelpPRVRARnplpQLRVVMSSGDRL 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1309 PPELVERWSER-GRRIFNCYGPTEATVWATRSRMT-AGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARG 1386
Cdd:PRK13383   305 DPTLGQRFMDTyGDILYNGYGSTEVGIGALATPADlRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTR 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1387 YLGRPGQTAVSfvadpfgepgaRMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVE 1466
Cdd:PRK13383   385 YTDGGGKAVVD-----------GMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVP 453

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 1467 STRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALP 1531
Cdd:PRK13383   454 DERFGHR---LAAFVVLHPGSGVDAAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELP 515

PRK05852

fatty acid--CoA ligase family protein;

2545-3061

4.07e-29

fatty acid--CoA ligase family protein;

Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 125.38 E-value: 4.07e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2545 LPAEAAVELTPVTGGPAtdpvtLAELFRAAARRAPDHVAVVDGAG-ARLTYRELDEASDRLARWLIGRGVGPERAVALAI 2623
Cdd:PRK05852     1 MRFMGGAAPMASDFGPR-----IADLVEVAATRLPEAPALVVTADrIAISYRDLARLVDDLAGQLTRSGLLPGDRVALRM 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2624 GRSAQLLTAIWAVAKTGGAYVPIDPDYPaerVASMIEDSGAVLGLSVLASGDLPGQEFE----WMRLDDdSVAAEIAAVP 2699
Cdd:PRK05852    76 GSNAEFVVALLAASRADLVVVPLDPALP---IAEQRVRSQAAGARVVLIDADGPHDRAEpttrWWPLTV-NVGGDSGPSG 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2700 AGPITDAERLGEVTAA---------NLAYVIYTSGSTGRPKGVAVTHSGLANFARQ--ESDRLNAGDNPVVLgfaSPSFD 2768
Cdd:PRK05852   152 GTLSVHLDAATEPTPAtstpeglrpDDAMIMFTGGTTGLPKMVPWTHANIASSVRAiiTGYRLSPRDATVAV---MPLYH 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2769 A-SVLEYLLATVNEGTLAYRPSEA-VGGEVLERFIAEHGAT--------HTFLTPSVLSTMDPTAVPSLRVI----AAGG 2834
Cdd:PRK05852   229 GhGLIAALLATLASGGAVLLPARGrFSAHTFWDDIKAVGATwytavptiHQILLERAATEPSGRKPAALRFIrscsAPLT 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2835 EAVPQPIVDRW-APATELhnlYGPTETTIGIT---ISSAMRPGDPVRLGGPIG---GVDLMVLDERLRPVPVGMPGELYV 2907
Cdd:PRK05852   309 AETAQALQTEFaAPVVCA---FGMTEATHQVTttqIEGIGQTENPVVSTGLVGrstGAQIRIVGSDGLPLPAGAVGEVWL 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2908 AGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAE 2987
Cdd:PRK05852   386 RGTTVVRGYLGDPTITAANFTDG--------WLRTGDLGSLSAAGD-----LSIRGRIKELINRGGEKISPERVEGVLAS 452

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2988 HDAVESAVVLGVGGSV-ATALAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK05852   453 HPNVMEAAVFGVPDQLyGEAVAAVIVPRESApPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAE 528

OSB_MenE-like

cd17630

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...

2717-3059

5.07e-29

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.

Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 120.51 E-value: 5.07e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2717 LAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLgFASPSFDASVLEYLLATVNEGTLAYRPSEAvgGEV 2796
Cdd:cd17630      2 LATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWL-LSLPLYHVGGLAILVRSLLAGAELVLLERN--QAL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2797 LERfIAEHGATHTFLTPSVLSTM-----DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT-ELHNLYGPTETTIGITISSAM 2870
Cdd:cd17630     79 AED-LAPPGVTHVSLVPTQLQRLldsgqGPAALKSLRAVLLGGAPIPPELLERAADRGiPLYTTYGMTETASQVATKRPD 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2871 RPGDPvRLGGPIGGVDLMVLDerlrpvpvgmPGELYVAGGALSRGYLDrsGLTAERFTANPYgtagqrmYRTGDVVRWTP 2950
Cdd:cd17630    158 GFGRG-GVGVLLPGRELRIVE----------DGEIWVGGASLAMGYLR--GQLVPEFNEDGW-------FTTKDLGELHA 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2951 DTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYIVPvDGAVEVSELKAFAGG 3029
Cdd:cd17630    218 DGR-----LTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEeLGQRPVAVIVG-RGPADPAELRAWLKD 291

                          330       340       350
                   ....*....|....*....|....*....|
gi 1827387616 3030 RLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd17630    292 KLARFKLPKRIYPVPELPRTGGGKVDRRAL 321

PRK07786

long-chain-fatty-acid--CoA ligase; Validated

2575-3076

6.44e-29

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 124.89 E-value: 6.44e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRA---PDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVG-PERAVALAIGRSaQLLTAIWAVAKTGGAYVPIDPDY 2650
Cdd:PRK07786    24 ARHAlmqPDAPAL-RFLGNTTTWRELDDRVAALAGALSRRGVGfGDRVLILMLNRT-EFVESVLAANMLGAIAVPVNFRL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2651 PAERVASMIEDSGA--VLGLSVLAS------GDLPGQEFEWM---RLDDDSVAAEIAAVPAGPITDAERLGEVTAAnlaY 2719
Cdd:PRK07786   102 TPPEIAFLVSDCGAhvVVTEAALAPvatavrDIVPLLSTVVVaggSSDDSVLGYEDLLAEAGPAHAPVDIPNDSPA---L 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHSGLANFArQESDRLNAGDNPVVLGF-ASPSFD----ASVLEYLL---ATVNEGTLAYRPSEA 2791
Cdd:PRK07786   179 IMYTSGTTGRPKGAVLTHANLTGQA-MTCLRTNGADINSDVGFvGVPLFHiagiGSMLPGLLlgaPTVIYPLGAFDPGQL 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 VggEVLERfiaeHGATHTFLTPSVLSTM--DPTAVP---SLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTig 2863
Cdd:PRK07786   258 L--DVLEA----EKVTGIFLVPAQWQAVcaEQQARPrdlALRVLSWGAAPASDTLLRQMAatfPEAQILAAFGQTEMS-- 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2864 iTISSAMRPGDPVR----LGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrM 2939
Cdd:PRK07786   330 -PVTCMLLGEDAIRklgsVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGG--------W 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2940 YRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATALAAyIVPVD 3015
Cdd:PRK07786   401 FHSGDLVR----QDEEGY-VWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRAdekwGEVPVAVAA-VRNDD 474

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 3016 GAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE-----PVLEAGEYVAPATGT 3076
Cdd:PRK07786   475 AALTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRErygacVNVERRSASAGFTER 540

PRK06155

crotonobetaine/carnitine-CoA ligase; Provisional

1009-1532

7.14e-29

crotonobetaine/carnitine-CoA ligase; Provisional

Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 124.49 E-value: 7.14e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1009 AARAKSV-SAPVSARTPGAMVGRggeveagtlidvlaQRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPED 1087
Cdd:PRK06155     7 GLAARAVdPLPPSERTLPAMLAR--------------QAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAAGVKRGD 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1088 VVAVGMERSIgSVLATW-GVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARL-----GESSCEWVDLADlE 1161
Cdd:PRK06155    73 RVALMCGNRI-EFLDVFlGCAWLGAIAVPINTALRGPQLEHILRNSGARLLVVEAALLAALeaadpGDLPLPAVWLLD-A 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1162 AEAESGDDITDTER---------NGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILH 1232
Cdd:PRK06155   151 PASVSVPAGWSTAPlppldapapAAAVQPGDTAAILYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADD-----VLY 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1233 VASPSFDASMFEM-AWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMI--ITPSVLA--TVDPERAQYVR-NLATGGe 1306
Cdd:PRK06155   226 TTLPLFHTNALNAfFQALLAGATYVLEPRFSASGFWPAVRRHGATVTYLLgaMVSILLSqpARESDRAHRVRvALGPGV- 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1307 acPPELVERWSER-GRRIFNCYGPTEATVwATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTA---G 1382
Cdd:PRK06155   305 --PAALHAAFRERfGVDLLDGYGSTETNF-VIAVTHGSQRPGSMGRLAPGFEARVVDEHDQELPDGEPGELLLRADepfA 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1383 LARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVV 1462
Cdd:PRK06155   382 FATGYFGMPEKTVEAWRNLWF--------HTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAV 453

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1463 VGVESTRGGrkhTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK06155   454 FPVPSELGE---DEVMAAVVLRDGTALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLRE 520

PRK13295

cyclohexanecarboxylate-CoA ligase; Reviewed

1-470

7.72e-29

cyclohexanecarboxylate-CoA ligase; Reviewed

Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 124.40 E-value: 7.72e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLdeqLPVDRAR---YMVRTAGVRLVV 77
Cdd:PRK13295    56 FTYRELAALVDRVAVGLARLGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLNPL---MPIFRERelsFMLKHAESKVLV 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   78 VTS-----DGEAEARSRFDDIVDV-HVLDISSPGDADLdEEEFAGPTR----------------PANAAFTLFTSGSTGR 135
Cdd:PRK13295   133 VPKtfrgfDHAAMARRLRPELPALrHVVVVGGDGADSF-EALLITPAWeqepdapailarlrpgPDDVTQLIYTSGTTGE 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  136 PKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPIT----FDVSVReifLPIAIGATLVIAEPGrhgDPVHLADLIRRH 211
Cdd:PRK13295   212 PKGVMHTANTLMANIVPYAERLGLGADDVILMASPMAhqtgFMYGLM---MPVMLGATAVLQDIW---DPARAAELIRTE 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  212 GVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRVTQDDRV 291
Cdd:PRK13295   286 GVTFTMASTPFLTDLTRAVKESGRPVSSLRTFLCAGAPIPGALVERARAAL-GAKIVSAWGMTENGAVTLTKLDDPDERA 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  292 IPI-GTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERfvADPFgepgarlYRTGDRARWNRDGEI 370
Cdd:PRK13295   365 STTdGCPLPGVEVRVVDADGAPLPAGQIGRLQVRGCSNFGGYLKRPQLNGTD--ADGW-------FDTGDLARIDADGYI 435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  371 EYLGRTDfQVKLRG-QRLELGEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGYLAP---ADVDVDTVAA--TTAELLP 441
Cdd:PRK13295   436 RISGRSK-DVIIRGgENIPVVEIEALLYRHPAI--AQVAIVAYPDerlGERACAFVVPrpgQSLDFEEMVEflKAQKVAK 512

                          490       500
                   ....*....|....*....|....*....
gi 1827387616  442 EYMrPSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK13295   513 QYI-PERLVVRDALPRTPSGKIQKFRLRE 540

ttLC_FACS_AEE21_like

cd12118

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...

2551-3056

8.30e-29

Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 123.56 E-value: 8.30e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2551 VELTPvtggpatdpvtLAELFRAAARRaPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLL 2630
Cdd:cd12118      2 VPLTP-----------LSFLERAAAVY-PDRTSIVYG-DRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMY 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2631 TAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGL--------SVLASGDlpgQEFEWMRLDDDSvaaeiaavpaGP 2702
Cdd:cd12118     69 ELHFGVPMAGAVLNALNTRLDAEEIAFILRHSEAKVLFvdrefeyeDLLAEGD---PDFEWIPPADEW----------DP 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2703 ITdaerlgevtaanlayVIYTSGSTGRPKGVAVTHSG-----LANFARQEsdrlnAGDNPVVLgFASPSFDASVLEYLLA 2777
Cdd:cd12118    136 IA---------------LNYTSGTTGRPKGVVYHHRGaylnaLANILEWE-----MKQHPVYL-WTLPMFHCNGWCFPWT 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2778 TVnegtlayrpseAVGG----------EVLERFIAEHGATHTFLTPSVLST----MDPTAVP---SLRVIAAGgeAVPQP 2840
Cdd:cd12118    195 VA-----------AVGGtnvclrkvdaKAIYDLIEKHKVTHFCGAPTVLNMlanaPPSDARPlphRVHVMTAG--APPPA 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2841 IVdrWAPATEL-----HnLYGPTETTIGITISSAMRPGDPV----------RLGGPIGGVD-LMVLD-ERLRPVP---VG 2900
Cdd:cd12118    262 AV--LAKMEELgfdvtH-VYGLTETYGPATVCAWKPEWDELpteerarlkaRQGVRYVGLEeVDVLDpETMKPVPrdgKT 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2901 MpGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGE 2980
Cdd:cd12118    339 I-GEIVFRGNIVMKGYLKNPEATAEAFRGG--------WFHSGDLAVIHPDG-----YIEIKDRSKDIIISGGENISSVE 404

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2981 IEAVLAEHDAVESAVVLGVG----GSVATalaAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFtVIDELPLTPVGKLD 3055
Cdd:cd12118    405 VEGVLYKHPAVLEAAVVARPdekwGEVPC---AFVELKEGAkVTEEEIIAFCREHLAGFMVPKTV-VFGELPKTSTGKIQ 480


                   .
gi 1827387616 3056 K 3056
Cdd:cd12118    481 K 481

PRK06145

acyl-CoA synthetase; Validated

2575-3059

8.53e-29

acyl-CoA synthetase; Validated

Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 123.84 E-value: 8.53e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAER 2654
Cdd:PRK06145    12 ARRTPDRAALVYR-DQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2655 VASMIEDSGAVLGLSVLASGDLPGQEFEWMRLDDDSVA-AEIAAVPAGPITDAERLGEvtaANLAYVIYTSGSTGRPKGV 2733
Cdd:PRK06145    91 VAYILGDAGAKLLLVDEEFDAIVALETPKIVIDAAAQAdSRRLAQGGLEIPPQAAVAP---TDLVRLMYTSGTTDRPKGV 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2734 AVTHSglaNFARQESDR-----LNAGDNPVVLGfasPSFDASVLEYL-LATVNEGTLAYRPSEAVGGEVLERfIAEHGAT 2807
Cdd:PRK06145   168 MHSYG---NLHWKSIDHvialgLTASERLLVVG---PLYHVGAFDLPgIAVLWVGGTLRIHREFDPEAVLAA-IERHRLT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2808 HTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIV---DRWAPATELHNLYGPTETTIGITISSAMRPGDPV-R 2877
Cdd:PRK06145   241 CAWMAPVMLSRVltvpdrDRFDLDSLAWCIGGGEKTPESRIrdfTRVFTRARYIDAYGLTETCSGDTLMEAGREIEKIgS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2878 LGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGDVVRWtpdTDTGGL 2957
Cdd:PRK06145   321 TGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFYGD--------WFRSGDVGYL---DEEGFL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2958 TLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-GGSVATALAAYIVPVDGA-VEVSELKAFAGGRLPAYM 3035
Cdd:PRK06145   390 YL--TDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVhDDRWGERITAVVVLNPGAtLTLEALDRHCRQRLASFK 467

                          490       500
                   ....*....|....*....|....
gi 1827387616 3036 VPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK06145   468 VPRQLKVRDELPRNPSGKVLKRVL 491

PRK12583

acyl-CoA synthetase; Provisional

2566-3065

9.67e-29

acyl-CoA synthetase; Provisional

Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 124.50 E-value: 9.67e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVV-DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:PRK12583    19 TIGDAFDATVARFPDREALVvRHQALRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAILV 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSG--------------------------AVLGLSVLASGDLPgqEFEWMRLDDDSVA------ 2692
Cdd:PRK12583    99 NINPAYRASELEYALGQSGvrwvicadafktsdyhamlqellpglAEGQPGALACERLP--ELRGVVSLAPAPPpgflaw 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2693 AEIAAvpAGPITDAERLGEVTAA----NLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPvVLGFASPSFD 2768
Cdd:PRK12583   177 HELQA--RGETVSREALAERQASldrdDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLGLTEHD-RLCVPVPLYH 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2769 --ASVLEYLLATVNEGTLAYrPSEAVGGEVLERFIAEHGATHTFLTPSV-LSTMDPTA-----VPSLRVIAAGGEAVPQP 2840
Cdd:PRK12583   254 cfGMVLANLGCMTVGACLVY-PNEAFDPLATLQAVEEERCTALYGVPTMfIAELDHPQrgnfdLSSLRTGIMAGAPCPIE 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2841 IVDRWAP---ATELHNLYGPTETTigiTISSAMRPGDPVRL-----GGPIGGVDLMVLDERLRPVPVGMPGELYVAGGAL 2912
Cdd:PRK12583   333 VMRRVMDemhMAEVQIAYGMTETS---PVSLQTTAADDLERrvetvGRTQPHLEVKVVDPDGATVPRGEIGELCTRGYSV 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2913 SRGYLDRSGLTAERFTANPYgtagqrMYrTGDVVrwTPDTDTgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVE 2992
Cdd:PRK12583   410 MKGYWNNPEATAESIDEDGW------MH-TGDLA--TMDEQG---YVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVA 477

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 2993 SAVVLGVGGS-VATALAAYIVPVDG-AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLE 3065
Cdd:PRK12583   478 DVQVFGVPDEkYGEEIVAWVRLHPGhAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREISIE 552

PRK13383

acyl-CoA synthetase; Provisional

2562-3060

9.74e-29

acyl-CoA synthetase; Provisional

Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 123.95 E-value: 9.74e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2562 TDPVTLAELfraAARRAPDHVAVVDGAGArLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGG 2641
Cdd:PRK13383    35 TNPYTLLAV---TAARWPGRTAIIDDDGA-LSYRELQRATESLARRLTRDGVAPGRAVGVMCRNGRGFVTAVFAVGLLGA 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2642 AYVPIDPDYPAERVASMIEDSgavlGLSVLASGDlpgqEF-EWMRLDDDSVAAeIAAVPAGPITDAERlgEVTAANLAYV 2720
Cdd:PRK13383   111 DVVPISTEFRSDALAAALRAH----HISTVVADN----EFaERIAGADDAVAV-IDPATAGAEESGGR--PAVAAPGRIV 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2721 IYTSGSTGRPKGV---AVTHSGLA-NFARQESDRLNAGDNpvvLGFASPSFDASVLEYLLATVnegtlayrpseAVGGEV 2796
Cdd:PRK13383   180 LLTSGTTGKPKGVpraPQLRSAVGvWVTILDRTRLRTGSR---ISVAMPMFHGLGLGMLMLTI-----------ALGGTV 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2797 LER--FIAE--------HGATHTFLTPSVLSTM--------DPTAVPSLRVIAAGGEAVPQPIVDRWAPATE--LHNLYG 2856
Cdd:PRK13383   246 LTHrhFDAEaalaqaslHRADAFTAVPVVLARIlelpprvrARNPLPQLRVVMSSGDRLDPTLGQRFMDTYGdiLYNGYG 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2857 PTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGltaerftanpyGTAG 2936
Cdd:PRK13383   326 STEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGG-----------KAVV 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2937 QRMYRTGDVVRwtpdTDTGGlTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYIVPVD 3015
Cdd:PRK13383   395 DGMTSTGDMGY----LDNAG-RLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDErFGHRLAAFVVLHP 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616 3016 GA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALP 3060
Cdd:PRK13383   470 GSgVDAAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELP 515

PRK06188

acyl-CoA synthetase; Validated

1-468

1.82e-28

acyl-CoA synthetase; Validated

Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 123.17 E-value: 1.82e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK06188    38 LTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPEVLMAIGAAQLAGLRRTALHPLGSLDDHAYVLEDAGISTLIVDP 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 ----DGEAEARSRFDDIVdvHVLDIS-SPGDADL-DEEEFAGPTRPANAAFTL------FTSGSTGRPKAVVITHRGIAN 148
Cdd:PRK06188   118 apfvERALALLARVPSLK--HVLTLGpVPDGVDLlAAAAKFGPAPLVAAALPPdiaglaYTGGTTGKPKGVMGTHRSIAT 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  149 RLAADIEQYDLTARDVFLYKAPITFDVSVreIFLPIAI-GATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFN 227
Cdd:PRK06188   196 MAQIQLAEWEWPADPRFLMCTPLSHAGGA--FFLPTLLrGGTVIVL---AKFDPAEVLRAIEEQRITATFLVPTMIYALL 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  228 EVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTI-----HRVTQDDRVIPIGTPTRRVS 302
Cdd:PRK06188   271 DHPDLRTRDLSSLETVYYGASPMSPVRLAEAIERF-GPIFAQYYGQTEAPMVITYlrkrdHDPDDPKRLTSCGRPTPGLR 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  303 ARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTD----- 377
Cdd:PRK06188   350 VALLDEDGREVAQGEVGEICVRGPLVMDGYWNRPEETAEAFRDG--------WLHTGDVAREDEDGFYYIVDRKKdmivt 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  378 --FQVKLRgqrlelgEVEAALAAAPGVlhAAAAVVDGPGGQQlvGYLAPADVDVDTVAATTAELLPEYMR--------PS 447
Cdd:PRK06188   422 ggFNVFPR-------EVEDVLAEHPAV--AQVAVIGVPDEKW--GEAVTAVVVLRPGAAVDAAELQAHVKerkgsvhaPK 490

                          490       500
                   ....*....|....*....|.
gi 1827387616  448 AWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK06188   491 QVDFVDSLPLTALGKPDKKAL 511

DCL_NRPS-like

cd19536

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

571-996

2.19e-28

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 121.02 E-value: 2.19e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  571 LPLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAA-PVQDVLP-VAVAREQ 648
Cdd:cd19536      2 YPLSSLQEGMLFHSLLNPGGSVYLHNYTYTVGRRLNLDLLLEALQVLIDRHDILRTSFIEDGLGqPVQVVHRqAQVPVTE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  649 LDWREADSVESLVRSTTE-----GFDVSTQMPLRGRFHRDGAGLHVALTM--HHIAMDGQSIPVLARDLMSAYAARAEGR 721
Cdd:cd19536     82 LDLTPLEEQLDPLRAYKEetkirRFDLGRAPLVRAALVRKDERERFLLVIsdHHSILDGWSLYLLVKEILAVYNQLLEYK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  722 TGGL-PVLDvqYADYALWQQSVLGDAddetsvlgEQLSHWRRVLAGlpaVTDLPMDRPRPAVLGTAGATVTVEFDDDLAD 800
Cdd:cd19536    162 PLSLpPAQP--YRDFVAHERASIQQA--------ASERYWREYLAG---ATLATLPALSEAVGGGPEQDSELLVSVPLPV 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  801 RVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRNDPA--LEELIGMFVNTLLLRTQVdPGHSVGDLLGNV 878
Cdd:cd19536    229 RSRSLAKRSGIPLSTLLLAAWALVLSRHSGSDDVVFGTVVHGRSEETtgAERLLGLFLNTLPLRVTL-SEETVEDLLKRA 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  879 RTTVLDAFANDQVQFDELiealapERSSSHQPLAQIAFTYTEPTVNDVAGLEASGIQAAPVDTGvVNAKFDLTVAVRARS 958
Cdd:cd19536    308 QEQELESLSHEQVPLADI------QRCSEGEPLFDSIVNFRHFDLDFGLPEWGSDEGMRRGLLF-SEFKSNYDVNLSVLP 380

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1827387616  959 GGTPMAADFIYATDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19536    381 KQDRLELKLAYNSQVLDEEQAQRLAAYYKSAIAELATA 418

ACS-like

cd17634

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...

2-463

2.31e-28

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.

Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 123.46 E-value: 2.31e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:cd17634     86 SYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGFAPEAVAGRIIDSSSRLLITADG 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEARS-----RFDDIVDV------HVL-------DISSPGDADLD---------EEEFAGPTRPANAAFTLFTSGSTG 134
Cdd:cd17634    166 GVRAGRSvplkkNVDDALNPnvtsveHVIvlkrtgsDIDWQEGRDLWwrdliakasPEHQPEAMNAEDPLFILYTSGTTG 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  135 RPKAVVITHRGIANRLAADIEQ-YDLTARDVFLYKAPITFDVSVRE-IFLPIAIGATLVIAEPG-RHGDPVHLADLIRRH 211
Cdd:cd17634    246 KPKGVLHTTGGYLVYAATTMKYvFDYGPGDIYWCTADVGWVTGHSYlLYGPLACGATTLLYEGVpNWPTPARMWQVVDKH 325

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  212 GVTVIHFVPAMLAAfneVLGAGVG-----ELTSLRLIQTGGEALTPPVARDLMVRLPGTR--LQNQYGPAEAS-IVVTIH 283
Cdd:cd17634    326 GVNILYTAPTAIRA---LMAAGDDaiegtDRSSLRILGSVGEPINPEAYEWYWKKIGKEKcpVVDTWWQTETGgFMITPL 402

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDdrvIPIGTPTRRV---SARVLDAALREVPIGVPGELYLGGV--QLARGYAGRPDLTAERFVADPFGepgarLYRT 358
Cdd:cd17634    403 PGAIE---LKAGSATRPVfgvQPAVVDNEGHPQPGGTEGNLVITDPwpGQTRTLFGDHERFEQTYFSTFKG-----MYFS 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  359 GDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGP---GGQQLVGY--LAPADVDVDTVA 433
Cdd:cd17634    475 GDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVAHPKV--AEAAVVGIPhaiKGQAPYAYvvLNHGVEPSPELY 552

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1827387616  434 ATTAELLPEYMRPSAWVR----LDAMPLSRSGKV 463
Cdd:cd17634    553 AELRNWVRKEIGPLATPDvvhwVDSLPKTRSGKI 586

ACS-like

cd17634

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...

1050-1525

3.92e-28

Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 123.07 E-value: 3.92e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTE------MDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD 1123
Cdd:cd17634     67 GDRTAIIYEGDDtsqsrtISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGFAPE 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 RIAYMLEDSGATVGITdASTRARLGESscewVDL---AD--LEAEAESGDDITDTERNGS-------------------- 1178
Cdd:cd17634    147 AVAGRIIDSSSRLLIT-ADGGVRAGRS----VPLkknVDdaLNPNVTSVEHVIVLKRTGSdidwqegrdlwwrdliakas 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1179 -------VRLTNLAYLIYTSGSTGRPKAVGVSHTG-IVDFVNSLAKITTGTPEDepdtrILHVASpsfdasmfEMAWAIP 1250
Cdd:cd17634    222 pehqpeaMNAEDPLFILYTSGTTGKPKGVLHTTGGyLVYAATTMKYVFDYGPGD-----IYWCTA--------DVGWVTG 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1251 ----------AGHTLVI---APQADfAGDALATVLERDEVTDMIITPSVLATVDPERAQYV--------RNLATGGEACP 1309
Cdd:cd17634    289 hsyllygplaCGATTLLyegVPNWP-TPARMWQVVDKHGVNILYTAPTAIRALMAAGDDAIegtdrsslRILGSVGEPIN 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1310 PE----LVERWSERGRRIFNCYGPTEaTVWATRSRMTAGKPVTIG---KPVDGFTVRVLDGRLHEVPQGVVGELYLSTA- 1381
Cdd:cd17634    368 PEayewYWKKIGKEKCPVVDTWWQTE-TGGFMITPLPGAIELKAGsatRPVFGVQPAVVDNEGHPQPGGTEGNLVITDPw 446

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1382 -GLARGYLGRPGQTAVSFVADPFGepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQS 1460
Cdd:cd17634    447 pGQTRTLFGDHERFEQTYFSTFKG-----MYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVAHPKVAEA 521

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1461 VVVGVestRGGRKHTEVVAYLVAKPGATiDSAAVLDE----AAQHLAAHMVPSQAIVIDEIPLTPAGKL 1525
Cdd:cd17634    522 AVVGI---PHAIKGQAPYAYVVLNHGVE-PSPELYAElrnwVRKEIGPLATPDVVHWVDSLPKTRSGKI 586

PRK06164

acyl-CoA synthetase; Validated

1038-1532

4.36e-28

acyl-CoA synthetase; Validated

Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 122.16 E-value: 4.36e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQRDldPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVD 1117
Cdd:PRK06164    14 SLLDAHARAR--PDAVALIDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVN 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1118 PAYPADRIAYMLEDSGATVGITDASTR-----ARLGESS-------------------------CEWVDLADLEAEAESG 1167
Cdd:PRK06164    92 TRYRSHEVAHILGRGRARWLVVWPGFKgidfaAILAAVPpdalpplraiavvddaadatpapapGARVQLFALPDPAPPA 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1168 DDItdtERNGSVRLTNLAYLiyTSGSTGRPKAVGVSHTGIVDFVNSLAKITTgtpeDEPDTRILHVASPSFDASMFEMAW 1247
Cdd:PRK06164   172 AAG---ERAADPDAGALLFT--TSGTTSGPKLVLHRQATLLRHARAIARAYG----YDPGAVLLAALPFCGVFGFSTLLG 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1248 AIPAGHTLVIAPQADFAgdALATVLERDEVTDMIITPSVLATV---DPERAQYVRNLATGGEACPP---ELVERWSERGR 1321
Cdd:PRK06164   243 ALAGGAPLVCEPVFDAA--RTARALRRHRVTHTFGNDEMLRRIldtAGERADFPSARLFGFASFAPalgELAALARARGV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1322 RIFNCYGPTEatVWATRSRMTAGKPVTI-----GKPVDG-FTVRV---LDGRLheVPQGVVGELYLSTAGLARGYLGRPG 1392
Cdd:PRK06164   321 PLTGLYGSSE--VQALVALQPATDPVSVrieggGRPASPeARVRArdpQDGAL--LPDGESGEIEIRAPSLMRGYLDNPD 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1393 QTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVesTRGGR 1472
Cdd:PRK06164   397 ATARALTDDGY-------FRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGA--TRDGK 467

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 1473 khTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAG---KLDRAALPE 1532
Cdd:PRK06164   468 --TVPVAFVIPTDGASPDEAGLMAACREALAGFKVPARVQVVEAFPVTESAngaKIQKHRLRE 528

MACS_AAE_MA_like

cd05970

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...

1039-1532

4.49e-28

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.

Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 122.22 E-value: 4.49e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1039 LIDVLAQRDldPDHPALI-CD--GTEMDYD--EFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAY 1113
Cdd:cd05970     22 VVDAMAKEY--PDKLALVwCDdaGEERIFTfaELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAIA 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1114 VPVDPAYPADRIAYMLEDSGATVGITDA------------------STRARLGESSCE-WVDLADLEAEAEsgDDITDTE 1174
Cdd:cd05970    100 IPATHQLTAKDIVYRIESADIKMIVAIAednipeeiekaapecpskPKLVWVGDPVPEgWIDFRKLIKNAS--PDFERPT 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1175 RNGSVRLTNLAYLIYTSGSTGRPKAVgvSHtgivDFVNSLAKITTGT--PEDEPDTRILHVASPSFDASM---FEMAWAi 1249
Cdd:cd05970    178 ANSYPCGEDILLVYFSSGTTGMPKMV--EH----DFTYPLGHIVTAKywQNVREGGLHLTVADTGWGKAVwgkIYGQWI- 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1250 pAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSV---LATVDPERAQY--VRNLATGGEACPPELVERWSER-GRRI 1323
Cdd:cd05970    251 -AGAAVFVYDYDKFDPKALLEKLSKYGVTTFCAPPTIyrfLIREDLSRYDLssLRYCTTAGEALNPEVFNTFKEKtGIKL 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNCYGPTEATVW-ATRSRMTAgKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTA-----GLARGYLGRPGQTAVS 1397
Cdd:cd05970    330 MEGFGQTETTLTiATFPWMEP-KPGSMGKPAPGYEIDLIDREGRSCEAGEEGEIVIRTSkgkpvGLFGGYYKDAEKTAEV 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1398 FvADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV-ESTRGGRKHTE 1476
Cdd:cd05970    409 W-HDGY-------YHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLECAVTGVpDPIRGQVVKAT 480

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 1477 VVAYLVAKPGATIDSaAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:cd05970    481 IVLAKGYEPSEELKK-ELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVEIRE 535

FACL_like_2

cd05917

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1189-1527

6.91e-28

Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 117.76 E-value: 6.91e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1189 YTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSFDAsmFEMAWAIPA----GHTLVIaPQADFA 1264
Cdd:cd05917      9 FTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQD-----RLCIPVPLFHC--FGSVLGVLAclthGATMVF-PSPSFD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1265 GDALATVLERDEVTDMIITPSVLATV--DPERAQY----VRNLATGGEACPPELVERWSER--GRRIFNCYGPTEATVWA 1336
Cdd:cd05917     81 PLAVLEAIEKEKCTALHGVPTMFIAEleHPDFDKFdlssLRTGIMAGAPCPPELMKRVIEVmnMKDVTIAYGMTETSPVS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1337 TRSRMTAG---KPVTIGKPVDGFTVRVLDGRLHEVPQ-GVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgepgaRMYA 1412
Cdd:cd05917    161 TQTRTDDSiekRVNTVGRIMPHTEAKIVDPEGGIVPPvGVPGELCIRGYSVMKGYWNDPEKTAEAIDGD-------GWLH 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1413 TGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSA 1492
Cdd:cd05917    234 TGDLAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGE---EVCAWIRLKEGAELTEE 310

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1827387616 1493 AVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd05917    311 DIKAYCKGKIAHYKVPRYVFFVDEFPLTVSGKIQK 345

FAA1

COG1022

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

2560-2998

1.18e-27

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 121.36 E-value: 1.18e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2560 PATDPVTLAELFRAAARRAPDHVAV---VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALaIGRS------AQLl 2630
Cdd:COG1022      6 DVPPADTLPDLLRRRAARFPDRVALrekEDGIWQSLTWAEFAERVRALAAGLLALGVKPGDRVAI-LSDNrpewviADL- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2631 tAIWAVaktGGAYVPIDPDYPAERVASMIEDSGAVLglsVLASG------------DLPGQEFEW------MRLDDDSVA 2692
Cdd:COG1022     84 -AILAA---GAVTVPIYPTSSAEEVAYILNDSGAKV---LFVEDqeqldkllevrdELPSLRHIVvldprgLRDDPRLLS 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2693 -AEIAAVPAGPITDAE---RLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVL-------- 2760
Cdd:COG1022    157 lDELLALGREVADPAEleaRRAAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGDRTLsflplahv 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2761 ----------------GFAS-------------PSFDASV---LEYLLATVNE-----GTLA---YRPSEAVGGEVLERF 2800
Cdd:COG1022    237 fertvsyyalaagatvAFAEspdtlaedlrevkPTFMLAVprvWEKVYAGIQAkaeeaGGLKrklFRWALAVGRRYARAR 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2801 IAEHG------ATHTFLTPSVLStmdptAV-----PSLRVIAAGGEAVPqPIVDRWapateLHNL-------YGPTETTI 2862
Cdd:COG1022    317 LAGKSpslllrLKHALADKLVFS-----KLrealgGRLRFAVSGGAALG-PELARF-----FRALgipvlegYGLTETSP 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2863 GITISsamRPGDpVRLG--G-PIGGVDLMVLDErlrpvpvgmpGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrm 2939
Cdd:COG1022    386 VITVN---RPGD-NRIGtvGpPLPGVEVKIAED----------GEILVRGPNVMKGYYKNPEATAEAFDADGW------- 444

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2940 YRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLR-GLRIELGEIEAVLAEHDAVESAVVLG 2998
Cdd:COG1022    445 LHTGDIGELDED---GFLRI--TGRKKDLIVTSgGKNVAPQPIENALKASPLIEQAVVVG 499

PRK09088

acyl-CoA synthetase; Validated

1045-1537

1.32e-27

acyl-CoA synthetase; Validated

Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 119.91 E-value: 1.32e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1045 QRDLDPDHPAL--ICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPA 1122
Cdd:PRK09088     4 HARLQPQRLAAvdLALGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1123 DRIAYMLEDSGATVGITDASTRArlgeSSCEWVDLADLEAEAEsGDDITDTERNGSVRLTnlaYLIYTSGSTGRPKAVGV 1202
Cdd:PRK09088    84 SELDALLQDAEPRLLLGDDAVAA----GRTDVEDLAAFIASAD-ALEPADTPSIPPERVS---LILFTSGTSGQPKGVML 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1203 SHTGIVDFVNSLAKITtgtpedepdtRILHVASPSFDASMFEMAWAIPA-------GHTLVIAPQADfAGDALATVLERD 1275
Cdd:PRK09088   156 SERNLQQTAHNFGVLG----------RVDAHSSFLCDAPMFHIIGLITSvrpvlavGGSILVSNGFE-PKRTLGRLGDPA 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1276 -EVTDMIITPSVLA------TVDPERAQYVRNLATGGEACPPELVERWSERGRRIFNCYGPTEA-TVW--ATRSRMTAGK 1345
Cdd:PRK09088   225 lGITHYFCVPQMAQafraqpGFDAAALRHLTALFTGGAPHAAEDILGWLDDGIPMVDGFGMSEAgTVFgmSVDCDVIRAK 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1346 PVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNL 1425
Cdd:PRK09088   305 AGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAFTGDGW-------FRTGDIARRDADGFF 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1426 EFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEAAQHLAA 1504
Cdd:PRK09088   378 WVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWG----EVgYLAIVPADGAPLDLERIRSHLSTRLAK 453

                          490       500       510
                   ....*....|....*....|....*....|...
gi 1827387616 1505 HMVPSQAIVIDEIPLTPAGKLDRAALPEPHAPE 1537
Cdd:PRK09088   454 YKVPKHLRLVDALPRTASGKLQKARLRDALAAG 486

PRK07798

acyl-CoA synthetase; Validated

4-466

1.48e-27

acyl-CoA synthetase; Validated

Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 120.38 E-value: 1.48e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGG-------HFVP--LDEQLPVDRARYMV------ 68
Cdd:PRK07798    32 AELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAvpvnvnyRYVEdeLRYLLDDSDAVALVyerefa 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   69 --------RTAGVRLVVVTSDGEAEARS----RFDDIVdvhvldisSPGDADLDeeefaGPTRPANAAFTLFTSGSTGRP 136
Cdd:PRK07798   112 prvaevlpRLPKLRTLVVVEDGSGNDLLpgavDYEDAL--------AAGSPERD-----FGERSPDDLYLLYTGGTTGMP 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  137 KAVVITHR--------GIANRLAADIEQYDLTARDVFLYKAPITFDVSvreiflPIAIGATL------------VIAEPG 196
Cdd:PRK07798   179 KGVMWRQEdifrvllgGRDFATGEPIEDEEELAKRAAAGPGMRRFPAP------PLMHGAGQwaafaalfsgqtVVLLPD 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  197 RHGDPVHLADLIRRHGVTVIHFV------PaMLAAFNEvlgAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQ 270
Cdd:PRK07798   253 VRFDADEVWRTIEREKVNVITIVgdamarP-LLDALEA---RGPYDLSSLFAIASGGALFSPSVKEALLELLPNVVLTDS 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  271 YGPAEASIVVTIhrvTQDDRVIPIGTP--TRRVSARVLDAALREVP--IGVPGELYLGGVqLARGYAGRPDLTAERF-VA 345
Cdd:PRK07798   329 IGSSETGFGGSG---TVAKGAVHTGGPrfTIGPRTVVLDEDGNPVEpgSGEIGWIARRGH-IPLGYYKDPEKTAETFpTI 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  346 DpfgepGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGYL 422
Cdd:PRK07798   405 D-----GVRYAIPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEALKAHPDV--ADALVVGVPDerwGQEVVAVV 477

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616  423 AP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRR 466
Cdd:PRK07798   478 QLregARPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGKADYR 524

OSB_MenE-like

cd17630

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...

1184-1530

1.53e-27

Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 116.28 E-value: 1.53e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1184 LAYLIYTSGSTGRPKAVGVS---HTGIVDFVNSLakittgTPEDEPDTRILhvASPSFDASMFEMAWA-IPAGHTLVIAP 1259
Cdd:cd17630      2 LATVILTSGSTGTPKAVVHTaanLLASAAGLHSR------LGFGGGDSWLL--SLPLYHVGGLAILVRsLLAGAELVLLE 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1260 QADfagdALATVLERDEVTDMIITPSVLATV-----DPERAQYVRNLATGGEACPPELVERWSERGRRIFNCYGPTEatv 1334
Cdd:cd17630     74 RNQ----ALAEDLAPPGVTHVSLVPTQLQRLldsgqGPAALKSLRAVLLGGAPIPPELLERAADRGIPLYTTYGMTE--- 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 waTRSRMTAGKPVTIGKPVDGftvRVLDGRlhEVPQGVVGELYLSTAGLARGYLGRPGQtavsfvaDPFGEPGarMYATG 1414
Cdd:cd17630    147 --TASQVATKRPDGFGRGGVG---VLLPGR--ELRIVEDGEIWVGGASLAMGYLRGQLV-------PEFNEDG--WFTTK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGAtiDSAAV 1494
Cdd:cd17630    211 DLGELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQR---PVAVIVGRGPA--DPAEL 285

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1827387616 1495 LDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd17630    286 RAWLKDKLARFKLPKRIYPVPELPRTGGGKVDRRAL 321

FadD3

cd17638

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...

1183-1525

1.74e-27

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.

Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 116.45 E-value: 1.74e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILhVASPSFDASMFEMAW--AIPAGHTLViaPQ 1260
Cdd:cd17638      1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDD----RYL-IINPFFHTFGYKAGIvaCLLTGATVV--PV 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1261 ADFAGDALATVLERDEVTDMIITPSVLATV--DPERAQY----VRNLATGGEACPPELVERW-SERG-RRIFNCYGPTEA 1332
Cdd:cd17638     74 AVFDVDAILEAIERERITVLPGPPTLFQSLldHPGRKKFdlssLRAAVTGAATVPVELVRRMrSELGfETVLTAYGLTEA 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1333 TVwATRSRmTAGKPVTI----GKPVDGFTVRVLDGrlhevpqgvvGELYLSTAGLARGYLGRPGQTAVSFVADPFgepga 1408
Cdd:cd17638    154 GV-ATMCR-PGDDAETVattcGRACPGFEVRIADD----------GEVLVRGYNVMQGYLDDPEATAEAIDADGW----- 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1409 rmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGA 1487
Cdd:cd17638    217 --LHTGDVGELDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMG----EVgKAFVVARPGV 290

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1827387616 1488 TIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKL 1525
Cdd:cd17638    291 TLTEEDVIAWCRERLANYKVPRFVRFLDELPRNASGKV 328

ACS-like

cd17634

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...

2576-3054

1.86e-27

Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 120.76 E-value: 1.86e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2576 RRAPDHVAVV----DGAGAR-LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDY 2650
Cdd:cd17634     64 RENGDRTAIIyegdDTSQSRtISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGF 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2651 PAERVASMIEDSGAVLglSVLASGDL-PGQEFEWMRLDDDsvAAEIAAVPAGPITDAERLG------------------- 2710
Cdd:cd17634    144 APEAVAGRIIDSSSRL--LITADGGVrAGRSVPLKKNVDD--ALNPNVTSVEHVIVLKRTGsdidwqegrdlwwrdliak 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2711 --------EVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDR---LNAGDnpVVLGFASPSF--DASVLEYLLA 2777
Cdd:cd17634    220 aspehqpeAMNAEDPLFILYTSGTTGKPKGVLHTTGGYLVYAATTMKYvfdYGPGD--IYWCTADVGWvtGHSYLLYGPL 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2778 TVNEGTLAY--RPSEAVGGEvLERFIAEHGATHTFLTPSVLSTM---DPTAV-----PSLRVIAAGGEAV-PQPivdrWA 2846
Cdd:cd17634    298 ACGATTLLYegVPNWPTPAR-MWQVVDKHGVNILYTAPTAIRALmaaGDDAIegtdrSSLRILGSVGEPInPEA----YE 372

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2847 PATE--------LHNLYGPTETTIGIT----ISSAMRPGDPVRlggPIGGVDLMVLDERLRPVPVGMPGELYVAGG--AL 2912
Cdd:cd17634    373 WYWKkigkekcpVVDTWWQTETGGFMItplpGAIELKAGSATR---PVFGVQPAVVDNEGHPQPGGTEGNLVITDPwpGQ 449

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2913 SRGYLDRSgltaERFTANpYGTAGQRMYRTGDVVRwtpdTDTGGLTLeYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVE 2992
Cdd:cd17634    450 TRTLFGDH----ERFEQT-YFSTFKGMYFSGDGAR----RDEDGYYW-ITGRSDDVINVAGHRLGTAEIESVLVAHPKVA 519

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 2993 SAVVLGVGGSV-ATALAAYIV----PVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKL 3054
Cdd:cd17634    520 EAAVVGIPHAIkGQAPYAYVVlnhgVEPSPELYAELRNWVRKEIGPLATPDVVHWVDSLPKTRSGKI 586

PRK07787

acyl-CoA synthetase; Validated

1049-1530

1.90e-27

acyl-CoA synthetase; Validated

Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 119.32 E-value: 1.90e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1049 DPDHPALICDGTEMDYDEFetrtnAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYM 1128
Cdd:PRK07787    13 ADIADAVRIGGRVLSRSDL-----AGAATAVAERVAGARRVAVLATPTLATVLAVVGALIAGVPVVPVPPDSGVAERRHI 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1129 LEDSGATvgitdastrARLGESSCEWVDLA----DLEAEAESGDDITDTErngsvrltNLAYLIYTSGSTGRPKAVGVSH 1204
Cdd:PRK07787    88 LADSGAQ---------AWLGPAPDDPAGLPhvpvRLHARSWHRYPEPDPD--------APALIVYTSGTTGPPKGVVLSR 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1205 TGIVDFVNSLAKITTGTPED----------------------EPDTRILHVASPSFDAsmfeMAWAIPAGHTLVIApqad 1262
Cdd:PRK07787   151 RAIAADLDALAEAWQWTADDvlvhglplfhvhglvlgvlgplRIGNRFVHTGRPTPEA----YAQALSEGGTLYFG---- 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1263 fagdaLATVLERdeVTDmiitpsvlatvDPERAQYV---RNLATGGEACPPELVERWSER-GRRIFNCYGPTEaTVWATR 1338
Cdd:PRK07787   223 -----VPTVWSR--IAA-----------DPEAARALrgaRLLVSGSAALPVPVFDRLAALtGHRPVERYGMTE-TLITLS 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1339 SRMTAG-KPVTIGKPVDGFTVRVLDGRLHEVPQGV--VGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGD 1415
Cdd:PRK07787   284 TRADGErRPGWVGLPLAGVETRLVDEDGGPVPHDGetVGELQVRGPTLFDGYLNRPDATAAAFTADGW-------FRTGD 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1416 LVRVAKGGNLEFAGR-ADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVakPGATIDSAAV 1494
Cdd:PRK07787   357 VAVVDPDGMHRIVGReSTDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQR---IVAYVV--GADDVAADEL 431

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 1827387616 1495 LDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK07787   432 IDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQL 467

LCL_NRPS-like

cd19540

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

2140-2535

3.20e-27

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 117.91 E-value: 3.20e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2140 VLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPA-EVTVPWSVIDLRAEDaasLDSRVEEVLATertnP 2218
Cdd:cd19540     29 ALRLTGALDVDALRAALADVVARHESLRTVFPEDDGGPYQVVLPAaEARPDLTVVDVTEDE---LAARLAEAARR----G 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2219 FDMAKPPLIRVVLVEHGDGAE-LVVTNHHLLIDGWSSPLVLADLLSLYATGqtftgslpgTSGR---------DFADHA- 2287
Cdd:cd19540    102 FDLTAELPLRARLFRLGPDEHvLVLVVHHIAADGWSMAPLARDLATAYAAR---------RAGRapdwaplpvQYADYAl 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2288 --RAV-ATADVEAGIAA-----WREVLAPVTEPtLVAPGHEP-SADAPPR--DHQFSIDVKVTERLEALARNNSTTMATV 2356
Cdd:cd19540    173 wqRELlGDEDDPDSLAArqlayWRETLAGLPEE-LELPTDRPrPAVASYRggTVEFTIDAELHARLAALAREHGATLFMV 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2357 VQFAWAMFLSRLTGTRTVTFAETVSGRspDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLP 2436
Cdd:cd19540    252 LHAALAVLLSRLGAGDDIPIGTPVAGR--GDEALDDLVGMFVNTLVLRTDVSGDPTFAELLARVRETDLAAFAHQDVPFE 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2437 RLVAQ------TGLPALFDTLAVYESFPVNVDSVAGIDAsSAGGLKLVGAKtsdathYPLNLS------ASRRGAELALK 2504
Cdd:cd19540    330 RLVEAlnpprsTARHPLFQVMLAFQNTAAATLELPGLTV-EPVPVDTGVAK------FDLSFTlterrdADGAPAGLTGE 402

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1827387616 2505 LKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19540    403 LEYATDLFDRSTAERLADRFVRVLEAVVADP 433

PRK07529

AMP-binding domain protein; Validated

1046-1530

3.85e-27

AMP-binding domain protein; Validated

Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 120.06 E-value: 3.85e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1046 RDLDPDHPALICDGTEMDYDEFETRTNA-----IARA--LLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAyVPVD 1117
Cdd:PRK07529    35 AARHPDAPALSFLLDADPLDRPETWTYAelladVTRTanLLHSlGVGPGDVVAFLLPNLPETHFALWGGEAAGIA-NPIN 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1118 PAYPADRIAYMLEDSGATVGITDAST-RARLGESSCE------------WVDLA-----------------------DLE 1161
Cdd:PRK07529   114 PLLEPEQIAELLRAAGAKVLVTLGPFpGTDIWQKVAEvlaalpelrtvvEVDLArylpgpkrlavplirrkaharilDFD 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1162 AE--AESGDDITDTERNGSVRLtnlAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSF- 1238
Cdd:PRK07529   194 AElaRQPGDRLFSGRPIGPDDV---AAYFHTGGTTGMPKLAQHTHGNEVANAWLGALLLGLGPGD-----TVFCGLPLFh 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1239 -DASMFEMAWAIPAGHTLVIAPQADFAGDALA----TVLERDEVTDMIITPSVLAT-----VDPERAQYVRNLATGGEAC 1308
Cdd:PRK07529   266 vNALLVTGLAPLARGAHVVLATPQGYRGPGVIanfwKIVERYRINFLSGVPTVYAAllqvpVDGHDISSLRYALCGAAPL 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1309 PPELVERWSER-GRRIFNCYGPTEATVWATRS-RMTAGKPVTIGKPVDGFTVRVL----DGR-LHEVPQGVVGELYLSTA 1381
Cdd:PRK07529   346 PVEVFRRFEAAtGVRIVEGYGLTEATCVSSVNpPDGERRIGSVGLRLPYQRVRVVilddAGRyLRDCAVDEVGVLCIAGP 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1382 GLARGYLgRPGQTAVSFVADpfgepgaRMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSV 1461
Cdd:PRK07529   426 NVFSGYL-EAAHNKGLWLED-------GWLNTGDLGRIDADGYFWLTGRAKDLIIRGGHNIDPAAIEEALLRHPAVALAA 497

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 1462 VVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEAAQHL---AAhmVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK07529   498 AVGRPDAHAG----ELpVAYVQLKPGASATEAELLAFARDHIaerAA--VPKHVRILDALPKTAVGKIFKPAL 564

PRK07786

long-chain-fatty-acid--CoA ligase; Validated

4-463

5.44e-27

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 118.73 E-value: 5.44e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTSDGE 83
Cdd:PRK07786    46 RELDDRVAALAGALSRRGVGFGDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLTPPEIAFLVSDCGAH-VVVTEAAL 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDIVDVHVLDISSPGDAD---LDEEEFAGPTRPANA---------AFTLFTSGSTGRPKAVVITHRGIANRLA 151
Cdd:PRK07786   125 APVATAVRDIVPLLSTVVVAGGSSDdsvLGYEDLLAEAGPAHApvdipndspALIMYTSGTTGRPKGAVLTHANLTGQAM 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  152 ADIEQYDL-TARDVFLYKAPITFDVSVREIFLPIAIGATLVIaEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVL 230
Cdd:PRK07786   205 TCLRTNGAdINSDVGFVGVPLFHIAGIGSMLPGLLLGAPTVI-YPLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQ 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  231 GAGVGELtSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIhrVTQDDRVIPIGT---PTRRVSARVLD 307
Cdd:PRK07786   284 QARPRDL-ALRVLSWGAAPASDTLLRQMAATFPEAQILAAFGQTEMSPVTCM--LLGEDAIRKLGSvgkVIPTVAARVVD 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  308 AALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDFQVKLRGQRL 387
Cdd:PRK07786   361 ENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGGWF--------HSGDLVRQDEEGYVWVVDRKKDMIISGGENI 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  388 ELGEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGYLAP----ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRS 460
Cdd:PRK07786   433 YCAEVENVLASHPDI--VEVAVIGRADekwGEVPVAVAAVrnddAALTLEDLAEFLTDRLARYKHPKALEIVDALPRNPA 510


                   ...
gi 1827387616  461 GKV 463
Cdd:PRK07786   511 GKV 513

OSB_MenE-like

cd17630

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...

124-468

1.01e-26

Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 113.97 E-value: 1.01e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  124 AFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPItFDVS-VREIFLPIAIGATLVIAEPGRhgdpv 202
Cdd:cd17630      3 ATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWLLSLPL-YHVGgLAILVRSLLAGAELVLLERNQ----- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  203 hlADLIRRH--GVTVIHFVPAMLAafnEVL--GAGVGELTSLRLIQTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASI 278
Cdd:cd17630     77 --ALAEDLAppGVTHVSLVPTQLQ---RLLdsGQGPAALKSLRAVLLGGAPIPPELLERAADR--GIPLYTTYGMTETAS 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  279 VVTIHRVtqddrvipiGTPTRRVSARVLDAalREVPIGVPGELYLGGVQLARGYAGRPdltaerfVADPFGEPGarLYRT 358
Cdd:cd17630    150 QVATKRP---------DGFGRGGVGVLLPG--RELRIVEDGEIWVGGASLAMGYLRGQ-------LVPEFNEDG--WFTT 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  359 GDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLhaAAAVVDGPG---GQQLVGYLAPAD-VDVDTVAA 434
Cdd:cd17630    210 KDLGELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVR--DAFVVGVPDeelGQRPVAVIVGRGpADPAELRA 287

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1827387616  435 TTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd17630    288 WLKDKLARFKLPKRIYPVPELPRTGGGKVDRRAL 321

4CL

cd05904

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...

2574-2999

1.05e-26

Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 117.34 E-value: 1.05e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2574 AARRAPDHVAVVDGA-GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPA 2652
Cdd:cd05904     14 FASAHPSRPALIDAAtGRALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTP 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2653 ERVASMIEDSGAVLGLSV------LASGDLP-----GQEFEWMRLDDDSVAAEIAAVPAGPITDAErlgevTAANLayvi 2721
Cdd:cd05904     94 AEIAKQVKDSGAKLAFTTaelaekLASLALPvvlldSAEFDSLSFSDLLFEADEAEPPVVVIKQDD-----VAALL---- 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2722 YTSGSTGRPKGVAVTHSGL-ANFARQESDRLNAGDNPVVLGFASPSFDAsvleYLLATVNEGTLAYRpSEAVggeVLERF 2800
Cdd:cd05904    165 YSSGTTGRSKGVMLTHRNLiAMVAQFVAGEGSNSDSEDVFLCVLPMFHI----YGLSSFALGLLRLG-ATVV---VMPRF 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2801 --------IAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWA---PATELHNLYGPTETTiG 2863
Cdd:cd05904    237 dleellaaIERYKVTHLPVVPPIVLALvkspivDKYDLSSLRQIMSGAAPLGKELIEAFRakfPNVDLGQGYGMTEST-G 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2864 ITISSAMRPGDPVRLGGpIG----GVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTanpygtaGQR 2938
Cdd:cd05904    316 VVAMCFAPEKDRAKYGS-VGrlvpNVEAKIVDpETGESLPPNQTGELWIRGPSIMKGYLNNPEATAATID-------KEG 387

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 2939 MYRTGDVVRWtpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV 2999
Cdd:cd05904    388 WLHTGDLCYI----DEDGY-LFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPY 443

OSB_CoA_lg

cd05912

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...

2592-3059

1.22e-26

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.

Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 115.52 E-value: 1.22e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLglsvl 2671
Cdd:cd05912      2 YTFAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVKL----- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrlddDSVAAeiaavpagpitdaerlgevtaanlayVIYTSGSTGRPKGVAVTHSGLANFARQESDRL 2751
Cdd:cd05912     77 -----------------DDIAT--------------------------IMYTSGTTGKPKGVQQTFGNHWWSAIGSALNL 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGDNPVVLGfASPSFDASVLEYLLATVNEGTLAYrpseavggeVLERF--------IAEHGATHTFLTPSVLSTM---D 2820
Cdd:cd05912    114 GLTEDDNWLC-ALPLFHISGLSILMRSVIYGMTVY---------LVDKFdaeqvlhlINSGKVTIISVVPTMLQRLleiL 183

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2821 PTAVP-SLRVIAAGGEAVPQPIVD----RWAPateLHNLYGPTETTIGI-TISSAMRPGDPVRLGGPIGGVDLMVLDERL 2894
Cdd:cd05912    184 GEGYPnNLRCILLGGGPAPKPLLEqckeKGIP---VYQSYGMTETCSQIvTLSPEDALNKIGSAGKPLFPVELKIEDDGQ 260

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2895 RPvpvGMPGELYVAGGALSRGYLDRSGLTAERFtANPYgtagqrmYRTGDVvrwtPDTDTGGLTLEYTGRSDdqvklrgL 2974
Cdd:cd05912    261 PP---YEVGEILLKGPNVTKGYLNRPDATEESF-ENGW-------FKTGDI----GYLDEEGFLYVLDRRSD-------L 318

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2975 RIELGE------IEAVLAEHDAVESAVVLGVG----GSVATAlaaYIVpVDGAVEVSELKAFAGGRLPAYMVPSSFTVID 3044
Cdd:cd05912    319 IISGGEniypaeIEEVLLSHPAIKEAGVVGIPddkwGQVPVA---FVV-SERPISEEELIAYCSEKLAKYKVPKKIYFVD 394

                          490
                   ....*....|....*
gi 1827387616 3045 ELPLTPVGKLDKRAL 3059
Cdd:cd05912    395 ELPRTASGKLLRHEL 409

MACS_like_2

cd05973

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1-468

1.23e-26

Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 116.08 E-value: 1.23e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVts 80
Cdd:cd05973      1 LTFGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARLVVT-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgEAEARSRFDDIVDVHvldisspgdadldeeefagptrpanaaftLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd05973     79 --DAANRHKLDSDPFVM-----------------------------MFTSGTTGLPKGVPVPLRALAAFGAYLRDAVDLR 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVF-----------LYKApitfdvsvreIFLPIAIGATLVIAEPGRHGDPVHlaDLIRRHGVTVIHFVPAmlaAFNEV 229
Cdd:cd05973    128 PEDSFwnaadpgwaygLYYA----------ITGPLALGHPTILLEGGFSVESTW--RVIERLGVTNLAGSPT---AYRLL 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  230 LGAGVGELT----SLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRvtQDDRVIPIGT-----PTRR 300
Cdd:cd05973    193 MAAGAEVPArpkgRLRRVSSAGEPLTPEVIRWFDAAL-GVPIHDHYGQTELGMVLANHH--ALEHPVHAGSagramPGWR 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  301 VSarVLDAALREVPIGVPGelylggvQLARGYAGRPDLTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQV 380
Cdd:cd05973    270 VA--VLDDDGDELGPGEPG-------RLAIDIANSPLMWFRGYQLPDTPAIDGGYYLTGDTVEFDPDGSFSFIGRADDVI 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  381 KLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVG---YLAPADVDVDTVAATTAELLPEYMRPSAWVR----LD 453
Cdd:cd05973    341 TMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKafvVLRGGHEGTPALADELQLHVKKRLSAHAYPRtihfVD 420

                          490
                   ....*....|....*
gi 1827387616  454 AMPLSRSGKVDRRLL 468
Cdd:cd05973    421 ELPKTPSGKIQRFLL 435

FACL_like_2

cd05917

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

128-465

1.46e-26

Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 113.91 E-value: 1.46e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPI--TFDvSVREIFLPIAIGATLVIAEPGRHGDPVHLA 205
Cdd:cd05917      9 FTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQDRLCIPVPLfhCFG-SVLGVLACLTHGATMVFPSPSFDPLAVLEA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 dlIRRHGVTVIHFVPAMlaaFNEVLGA---GVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTI 282
Cdd:cd05917     88 --IEKEKCTALHGVPTM---FIAELEHpdfDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNMKDVTIAYGMTETSPVSTQ 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  283 HRV--TQDDRVIPIGTPTRRVSARVLDAALREVP-IGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgaRLYRTG 359
Cdd:cd05917    163 TRTddSIEKRVNTVGRIMPHTEAKIVDPEGGIVPpVGVPGELCIRGYSVMKGYWNDPEKTAEAIDGD-------GWLHTG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  360 DRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAA-AAVVDGPGGQQLVGYLAP---ADVDVDTVAAT 435
Cdd:cd05917    236 DLAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQvVGVPDERYGEEVCAWIRLkegAELTEEDIKAY 315

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1827387616  436 TAELLPEYMRPsAWVR-LDAMPLSRSGKVDR 465
Cdd:cd05917    316 CKGKIAHYKVP-RYVFfVDEFPLTVSGKIQK 345

BACL_like

cd05929

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...

1048-1530

1.82e-26

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.

Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 116.32 E-value: 1.82e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1048 LDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPaDRIAY 1127
Cdd:cd05929      4 RDLDRAQVFHQRRLLLLDVYSIALNRNARAAAAEGVWIADGVYIYLINSILTVFAAAAAWKCGACPAYKSSRAP-RAEAC 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 M--------LEDSGATVGitdastrarlgesSCEWVDLADLEAEAESGDDITDTERNGSvrltnlaYLIYTSGSTGRPKA 1199
Cdd:cd05929     83 AiieikaaaLVCGLFTGG-------------GALDGLEDYEAAEGGSPETPIEDEAAGW-------KMLYSGGTTGRPKG 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1200 VGVSHTGIVDFVNSLAKITTGTPEDEpDTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADfAGDALATVlERDEVTD 1279
Cdd:cd05929    143 IKRGLPGGPPDNDTLMAAALGFGPGA-DSVYLSPAPLYHAAPFRWSMTALFMGGTLVLMEKFD-PEEFLRLI-ERYRVTF 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1280 MIITPS----VLATVDPERAQY----VRNLATGGEACPPELVERWSE-RGRRIFNCYGPTEA--------TVWATRsrmt 1342
Cdd:cd05929    220 AQFVPTmfvrLLKLPEAVRNAYdlssLKRVIHAAAPCPPWVKEQWIDwGGPIIWEYYGGTEGqgltiingEEWLTH---- 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1343 agkPVTIGKPVDGfTVRVLDGRLHEVPQGVVGELYLSTAGlARGYLGRPGQTAVSFVADPFGepgarmyATGDLVRVAKG 1422
Cdd:cd05929    296 ---PGSVGRAVLG-KVHILDEDGNEVPPGEIGEVYFANGP-GFEYTNDPEKTAAARNEGGWS-------TLGDVGYLDED 363

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1423 GNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGA---TIDSAAVLDEAA 1499
Cdd:cd05929    364 GYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQ---RVHAVVQPAPGAdagTALAEELIAFLR 440

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1827387616 1500 QHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05929    441 DRLSRYKCPRSIEFVAELPRDDTGKLYRRLL 471

ABCL

cd05958

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...

2589-3059

1.91e-26

Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 115.65 E-value: 1.91e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2589 GARLTYRELDEASDRLARWLIGRGVG-PERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDsgavlg 2667
Cdd:cd05958      8 EREWTYRDLLALANRIANVLVGELGIvPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYILDK------ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2668 lsvlasgdlpgqefewmrldddsvAAEIAAVPAGPITDAErlgevtaaNLAYVIYTSGSTGRPKGVAVTHSGLANFAR-- 2745
Cdd:cd05958     82 ------------------------ARITVALCAHALTASD--------DICILAFTSGTTGAPKATMHFHRDPLASADry 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2746 -------QESDRLnAGDNPVVLGFASpsfdASVLEYLLAtVNEGTLAYrpSEAVGGEVLErFIAEHGATHTFLTPSVLST 2818
Cdd:cd05958    130 avnvlrlREDDRF-VGSPPLAFTFGL----GGVLLFPFG-VGASGVLL--EEATPDLLLS-AIARYKPTVLFTAPTAYRA 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2819 M---DPTAVP---SLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETtIGITISSamRPGD--PVRLGGPIGGVDLM 2888
Cdd:cd05958    201 MlahPDAAGPdlsSLRKCVSAGEALPAALHRAWKEATgiPIIDGIGSTEM-FHIFISA--RPGDarPGATGKPVPGYEAK 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2889 VLDERLRPVPVGMPGELYVAGGALSRGYLDRSgltAERFTANPYGTAGQRMYRTGDVVRWtpdtdtggltleYTGRSDDQ 2968
Cdd:cd05958    278 VVDDEGNPVPDGTIGRLAVRGPTGCRYLADKR---QRTYVQGGWNITGDTYSRDPDGYFR------------HQGRSDDM 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2969 VKLRGLRIELGEIEAVLAEHDAVESAVVLGV----GGSVATalaAYIVP----VDGAVEVSELKAFAGGRLPAYMVPSSF 3040
Cdd:cd05958    343 IVSGGYNIAPPEVEDVLLQHPAVAECAVVGHpdesRGVVVK---AFVVLrpgvIPGPVLARELQDHAKAHIAPYKYPRAI 419

                          490
                   ....*....|....*....
gi 1827387616 3041 TVIDELPLTPVGKLDKRAL 3059
Cdd:cd05958    420 EFVTELPRTATGKLQRFAL 438

PRK07059

Long-chain-fatty-acid--CoA ligase; Validated

2560-3059

3.19e-26

Long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 116.66 E-value: 3.19e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2560 PATDPVTLAELFRAAARRAPDHVAVVdGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKT 2639
Cdd:PRK07059    18 DASQYPSLADLLEESFRQYADRPAFI-CMGKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAVLRA 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2640 GGAYVPIDPDYPAERVASMIEDSGA---------------VLG------LSVLASGDLPGQEFEWMRLDDDSVAAeiaAV 2698
Cdd:PRK07059    97 GYVVVNVNPLYTPRELEHQLKDSGAeaivvlenfattvqqVLAktavkhVVVASMGDLLGFKGHIVNFVVRRVKK---MV 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2699 PAGPITDAERLGEVTAA--------------NLAYVIYTSGSTGRPKGVAVTHSG-LANFARQES---DRLNAGDNPVVL 2760
Cdd:PRK07059   174 PAWSLPGHVRFNDALAEgarqtfkpvklgpdDVAFLQYTGGTTGVSKGATLLHRNiVANVLQMEAwlqPAFEKKPRPDQL 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2761 GF--ASPSFD--ASVLEYLLATVNEGT--LAYRPSEAVGgevlerFIAEHG--ATHTF-----LTPSVLSTMDPTAV--P 2825
Cdd:PRK07059   254 NFvcALPLYHifALTVCGLLGMRTGGRniLIPNPRDIPG------FIKELKkyQVHIFpavntLYNALLNNPDFDKLdfS 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2826 SLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPG 2903
Cdd:PRK07059   328 KLIVANGGGMAVQRPVAERWLEMTgcPITEGYGLSETSPVATCNPVDATEFSGTIGLPLPSTEVSIRDDDGNDLPLGEPG 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2904 ELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtgGLTlEYTGRSDDQVKLRGLRIELGEIEA 2983
Cdd:PRK07059   408 EICIRGPQVMAGYWNRPDETAKVMTADGF-------FRTGDVGVMDER----GYT-KIVDRKKDMILVSGFNVYPNEIEE 475

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 2984 VLAEHDAVESAVVLGV-GGSVATALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK07059   476 VVASHPGVLEVAAVGVpDEHSGEAVKLFVVKKDPALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRREL 552

OSB_CoA_lg

cd05912

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...

4-468

4.01e-26

Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 113.98 E-value: 4.01e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLvvvtsdge 83
Cdd:cd05912      5 AELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVKL-------- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aearsrfDDIvdvhvldisspgdadldeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05912     77 -------DDI------------------------------ATIMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLGLTEDD 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPItFDVSVREIFLPIAIGATLVIAEPgrHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGEltSLRLI 243
Cdd:cd05912    120 NWLCALPL-FHISGLSILMRSVIYGMTVYLVD--KFDAEQVLHLINSGKVTIISVVPTMLQRLLEILGEGYPN--NLRCI 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  244 QTGGEALTPPVARDLMVRlpGTRLQNQYGPAE-ASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAalrEVPIGVPGELY 322
Cdd:cd05912    195 LLGGGPAPKPLLEQCKEK--GIPVYQSYGMTEtCSQIVTLSPEDALNKIGSAGKPLFPVELKIEDD---GQPPYEVGEIL 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  323 LGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGV 402
Cdd:cd05912    270 LKGPNVTKGYLNRPDATEESFENGWF--------KTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAI 341

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  403 lhAAAAVVDGPG---GQQLVGYL-APADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05912    342 --KEAGVVGIPDdkwGQVPVAFVvSERPISEEELIAYCSEKLAKYKVPKKIYFVDELPRTASGKLLRHEL 409

PRK06839

o-succinylbenzoate--CoA ligase;

1-470

6.03e-26

o-succinylbenzoate--CoA ligase;

Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 114.96 E-value: 6.03e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLAREL-TALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVT 79
Cdd:PRK06839    28 MTYKQLHEYVSKVAAYLiYELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRLTENELIFQLKDSGTTVLFVE 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   80 SDGEAEARSRFDDIVDVHVLDISSPG---DADLDEEEFAGPTRPAnaaFTLFTSGSTGRPKAVVITHRGIANRLAADIEQ 156
Cdd:PRK06839   108 KTFQNMALSMQKVSYVQRVISITSLKeieDRKIDNFVEKNESASF---IICYTSGTTGKPKGAVLTQENMFWNALNNTFA 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  157 YDLTARDVFLYKAPItFDVSVREIFLPIAIGATLVIAEPGRHgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGE 236
Cdd:PRK06839   185 IDLTMHDRSIVLLPL-FHIGGIGLFAFPTLFAGGVIIVPRKF-EPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTN 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 LTSLRLIQTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASivVTIHRVTQDD---RVIPIGTPTRRVSARVLDAALREV 313
Cdd:PRK06839   263 LQSVRWFYNGGAPCPEELMREFIDR--GFLFGQGFGMTETS--PTVFMLSEEDarrKVGSIGKPVLFCDYELIDENKNKV 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  314 PIGVPGELYLGGVQLARGYAGRPDLTAERfVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVE 393
Cdd:PRK06839   339 EVGEVGELLIRGPNVMKEYWNRPDATEET-IQDGW-------LCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVE 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  394 AALAAAPGVLHAAAAVVDGPG-GQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLP 469
Cdd:PRK06839   411 QVINKLSDVYEVAVVGRQHVKwGEIPIAFIVKkssSVLIEKDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLV 490


                   .
gi 1827387616  470 E 470
Cdd:PRK06839   491 N 491

PRK06060

p-hydroxybenzoic acid--AMP ligase FadD22;

1074-1530

6.33e-26

p-hydroxybenzoic acid--AMP ligase FadD22;

Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 117.05 E-value: 6.33e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1074 IARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCe 1153
Cdd:PRK06060    43 LGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDALRDRFQPSRV- 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1154 wVDLADLEAEAESGDDiTDTERNGSvrlTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLA-KITTGTPEDEPdtriLH 1232
Cdd:PRK06060   122 -AEAAELMSEAARVAP-GGYEPMGG---DALAYATYTSGTTGPPKAAIHRHADPLTFVDAMCrKALRLTPEDTG----LC 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1233 VASPSFDASMFEMAW-AIPAGHTLVIAPqADFAGDALATVLERDEVTDMIITPSVLATV----DPERAQYVRNLATGGEA 1307
Cdd:PRK06060   193 SARMYFAYGLGNSVWfPLATGGSAVINS-APVTPEAAAILSARFGPSVLYGVPNFFARVidscSPDSFRSLRCVVSAGEA 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1308 CPPELVERWSE--RGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLAR 1385
Cdd:PRK06060   272 LELGLAERLMEffGGIPILDGIGSTEVGQTFVSNRVDEWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAK 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1386 GYLGRPgqtavsfvaDPFGEPGARMyATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV 1465
Cdd:PRK06060   352 GYWNRP---------DSPVANEGWL-DTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAV 421

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1466 ESTRGGrkhTEVVAYLVAKPGATIDSAAVLD---EAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK06060   422 RESTGA---STLQAFLVATSGATIDGSVMRDlhrGLLNRLSAFKVPHRFAVVDRLPRTPNGKLVRGAL 486

PRK06839

o-succinylbenzoate--CoA ligase;

2573-3061

8.43e-26

o-succinylbenzoate--CoA ligase;

Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 114.57 E-value: 8.43e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2573 AAARRAPDHVAVVdGAGARLTYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYP 2651
Cdd:PRK06839    10 KRAYLHPDRIAII-TEEEEMTYKQLHEYVSKVAAYLIYElNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRLT 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2652 AERVASMIEDSGAVLglsVLASgdlpgQEFEWMRLD---DDSVAAEIAAVPAGPITDAERLG-EVTAANLAYVI-YTSGS 2726
Cdd:PRK06839    89 ENELIFQLKDSGTTV---LFVE-----KTFQNMALSmqkVSYVQRVISITSLKEIEDRKIDNfVEKNESASFIIcYTSGT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2727 TGRPKGVAVThsglanfarQESDRLNAGDNPVVLGFASPsfDASVLEYLLATVNEGTLAYRPSEAVGGEVLE-------- 2798
Cdd:PRK06839   161 TGKPKGAVLT---------QENMFWNALNNTFAIDLTMH--DRSIVLLPLFHIGGIGLFAFPTLFAGGVIIVprkfeptk 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2799 --RFIAEHGATHTFLTPSV------LSTMDPTAVPSLRVIAAGGEAVPQPIV----DRWAPateLHNLYGPTETTIGITI 2866
Cdd:PRK06839   230 alSMIEKHKVTVVMGVPTIhqalinCSKFETTNLQSVRWFYNGGAPCPEELMrefiDRGFL---FGQGFGMTETSPTVFM 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2867 SS----AMRPGDpvrLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAErftanpygTAGQRMYRT 2942
Cdd:PRK06839   307 LSeedaRRKVGS---IGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEE--------TIQDGWLCT 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2943 GDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATalaAYIVPVDGAV 3018
Cdd:PRK06839   376 GDLARVDED---GFVYI--VGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQhvkwGEIPI---AFIVKKSSSV 447

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 3019 EV-SELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK06839   448 LIeKDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVN 491

AAS_C

cd05909

C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...

2586-3059

9.46e-26

Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 114.35 E-value: 9.46e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2586 DGAGARLTYRELDEASDRLARwLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGgaYVPIDPDYPA--ERVASMIEDSG 2663
Cdd:cd05909      2 DTLGTSLTYRKLLTGAIALAR-KLAKMTKEGENVGVMLPPSAGGALANFALALSG--KVPVMLNYTAglRELRACIKLAG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2664 AVlglSVLAS------GDLPG-----QEFEWMRLDD----DSVAAEIAAVPAGPITDAE---RLGEVT--AANLAYVIYT 2723
Cdd:cd05909     79 IK---TVLTSkqfiekLKLHHlfdveYDARIVYLEDlrakISKADKCKAFLAGKFPPKWllrIFGVAPvqPDDPAVILFT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2724 SGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASP--SFDASVLeyLLATVNEGTLAYRPSEAVGGEVLERFI 2801
Cdd:cd05909    156 SGSEGLPKGVVLSHKNLLANVEQITAIFDPNPEDVVFGALPFfhSFGLTGC--LWLPLLSGIKVVFHPNPLDYKKIPELI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2802 AEHGATHTFLTPSVLS----TMDPTAVPSLRVIAAGGEAVPQPIVDRWAP--ATELHNLYGPTETTIGITISSAMRPGDP 2875
Cdd:cd05909    234 YDKKATILLGTPTFLRgyarAAHPEDFSSLRLVVAGAEKLKDTLRQEFQEkfGIRILEGYGTTECSPVISVNTPQSPNKE 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2876 VRLGGPIGGVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFtanpygtaGQRMYRTGDVVRWTPDtdt 2954
Cdd:cd05909    314 GTVGRPLPGMEVKIVSvETHEEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAF--------GDGWYDTGDIGKIDGE--- 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2955 GGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEH--DAVESAVVLGVGGSVATALAAYIVPVDGavEVSELKAFA-GGRL 3031
Cdd:cd05909    383 GFLTI--TGRLSRFAKIAGEMVSLEAIEDILSEIlpEDNEVAVVSVPDGRKGEKIVLLTTTTDT--DPSSLNDILkNAGI 458

                          490       500
                   ....*....|....*....|....*...
gi 1827387616 3032 PAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05909    459 SNLAKPSYIHQVEEIPLLGTGKPDYVTL 486

FAAL

cd05931

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...

1050-1529

1.16e-25

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.

Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 114.64 E-value: 1.16e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPAL--ICDGTEMD----YDEFETRTNAIARALLARGvSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPV---DPAY 1120
Cdd:cd05931      7 PDRPAYtfLDDEGGREetltYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLpppTPGR 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1121 PADRIAYMLEDSGATVGITDASTRARLGE--SSCEWVDLADLEAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPK 1198
Cdd:cd05931     86 HAERLAAILADAGPRVVLTTAAALAAVRAfaASRPAAGTPRLLVVDLLPDTSAADWPPPSPDPDDIAYLQYTSGSTGTPK 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1199 AVGVSHTGIVDFVNSLAKITTGTPEDepdtrilHVAS--PSF-DASMFeMAWAIPA--GHTLVIAPQADFAGD------- 1266
Cdd:cd05931    166 GVVVTHRNLLANVRQIRRAYGLDPGD-------VVVSwlPLYhDMGLI-GGLLTPLysGGPSVLMSPAAFLRRplrwlrl 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1267 --------------ALATVLERdevtdmiITPSVLATVDPERaqyVRNLATGGEACPPELVERWSERGRR-------IFN 1325
Cdd:cd05931    238 isryratisaapnfAYDLCVRR-------VRDEDLEGLDLSS---WRVALNGAEPVRPATLRRFAEAFAPfgfrpeaFRP 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1326 CYGPTEATVWATRSRMTAGKPVTI--------------------------GKPVDGFTVRVLD-GRLHEVPQGVVGELYL 1378
Cdd:cd05931    308 SYGLAEATLFVSGGPPGTGPVVLRvdrdalagravavaaddpaarelvscGRPLPDQEVRIVDpETGRELPDGEVGEIWV 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1379 STAGLARGYLGRPGQTAVSFVADPfGEPGARMYATGDLVRVAkGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVA 1458
Cdd:cd05931    388 RGPSVASGYWGRPEATAETFGALA-ATDEGGWLRTGDLGFLH-DGELYITGRLKDLIIVRGRNHYPQDIEATAEEAHPAL 465

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 1459 QSVVVGVESTRGGRKHTEVVAYLVAKPGATIDSAAVLDEAAQHLA-AHMVPSQAIVI---DEIPLTPAGKLDRAA 1529
Cdd:cd05931    466 RPGCVAAFSVPDDGEERLVVVAEVERGADPADLAAIAAAIRAAVArEHGVAPADVVLvrpGSIPRTSSGKIQRRA 540

PRK08314

long-chain-fatty-acid--CoA ligase; Validated

2-474

1.38e-25

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 114.67 E-value: 1.38e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLAREL-TALGV--GAEVAVGIQidRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVV 78
Cdd:PRK08314    37 SYRELLEEAERLAGYLqQECGVrkGDRVLLYMQ--NSPQFVIAYYAILRANAVVVPVNPMNREEELAHYVTDSGARVAIV 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   79 TSD---------GEAEAR----SRFDDIVDVH--------------VLDISSPGDADLDEEEFAG-PTRPANA-----AF 125
Cdd:PRK08314   115 GSElapkvapavGNLRLRhvivAQYSDYLPAEpeiavpawlraeppLQALAPGGVVAWKEALAAGlAPPPHTAgpddlAV 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  126 TLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPItFDVS--VREIFLPIAIGATLVIAEpgrHGDPVH 203
Cdd:PRK08314   195 LPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESVVLAVLPL-FHVTgmVHSMNAPIYAGATVVLMP---RWDREA 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  204 LADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEaSIVVTIH 283
Cdd:PRK08314   271 AARLIERYRVTHWTNIPTMVVDFLASPGLAERDLSSLRYIGGGGAAMPEAVAERLK-ELTGLDYVEGYGLTE-TMAQTHS 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIPIGTPTRRVSARVLDAA-LREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVA-DpfgepGARLYRTGDR 361
Cdd:PRK08314   349 NPPDRPKLQCLGIPTFGVDARVIDPEtLEELPPGEVGEIVVHGPQVFKGYWNRPEATAEAFIEiD-----GKRFFRTGDL 423

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  362 ARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADvdvDTVAATTAELL 440
Cdd:PRK08314   424 GRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACViATPDPRRGETVKAVVVLRP---EARGKTTEEEI 500

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1827387616  441 PEYMR--------PSAWVRLDAMPLSRSGKVDRRLLPEPEIA 474
Cdd:PRK08314   501 IAWARehmaaykyPRIVEFVDSLPKSGSGKILWRQLQEQEKA 542

MACS_euk

cd05928

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...

1082-1530

1.84e-25

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.

Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 114.10 E-value: 1.84e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1082 GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAS----------------TRA 1145
Cdd:cd05928     63 GLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCIVTSDElapevdsvasecpslkTKL 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1146 RLGESSCE-WVDLADLEAEAESGDDITDTErngsvrlTNLAYLIY-TSGSTGRPKAVGVSHT--GIVDFVNSlAKITTGT 1221
Cdd:cd05928    143 LVSEKSRDgWLNFKELLNEASTEHHCVETG-------SQEPMAIYfTSGTTGSPKMAEHSHSslGLGLKVNG-RYWLDLT 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1222 PED----EPDTRILHVASpsfdASMFEmAWaiPAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSV---LATVDPER 1294
Cdd:cd05928    215 ASDimwnTSDTGWIKSAW----SSLFE-PW--IQGACVFVHHLPRFDPLVILKTLSSYPITTFCGAPTVyrmLVQQDLSS 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1295 AQY--VRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQG 1371
Cdd:cd05928    288 YKFpsLQHCVTGGEPLNPEVLEKWKAQtGLDIYEGYGQTETGLICANFKGMKIKPGSMGKASPPYDVQIIDDNGNVLPPG 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1372 VVGELYLSTA-----GLARGYLGRPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGE 1446
Cdd:cd05928    368 TEGDIGIRVKpirpfGLFSGYVDNPEKTAATIRGD--------FYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFE 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1447 IEAVLDAQPGVAQSVVVGV-ESTRGgrkhtEVV-AYLV-AKPGATIDSAAVLDEAAQHL----AAHMVPSQAIVIDEIPL 1519
Cdd:cd05928    440 VESALIEHPAVVESAVVSSpDPIRG-----EVVkAFVVlAPQFLSHDPEQLTKELQQHVksvtAPYKYPRKVEFVQELPK 514

                          490
                   ....*....|.
gi 1827387616 1520 TPAGKLDRAAL 1530
Cdd:cd05928    515 TVTGKIQRNEL 525

VL_LC_FACS_like

cd05907

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...

2592-3019

1.85e-25

Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 112.69 E-value: 1.85e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVAL-AIGRSAQLLT--AIWAVaktGGAYVPIDPDYPAERVASMIEDSGAVLgl 2668
Cdd:cd05907      6 ITWAEFAEEVRALAKGLIALGVEPGDRVAIlSRNRPEWTIAdlAILAI---GAVPVPIYPTSSAEQIAYILNDSEAKA-- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2669 sVLASgdlpgqefewmrldddsvaaeiaavpagpitdaerlgevTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQES 2748
Cdd:cd05907     81 -LFVE---------------------------------------DPDDLATIIYTSGTTGRPKGVMLSHRNILSNALALA 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2749 DRLNAGDNPVVLGFAsPSfdASVLE----YLLATVNEGTLAYRPSEAVGGEVLERF----------IAE--HGATHTFLT 2812
Cdd:cd05907    121 ERLPATEGDRHLSFL-PL--AHVFErragLYVPLLAGARIYFASSAETLLDDLSEVrptvflavprVWEkvYAAIKVKAV 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2813 PSVLSTMDPTAV-PSLRVIAAGGEAVPQPIVDRWAPA-TELHNLYGPTETTIGITISsamRPGDPV--RLGGPIGGVDLM 2888
Cdd:cd05907    198 PGLKRKLFDLAVgGRLRFAASGGAPLPAELLHFFRALgIPVYEGYGLTETSAVVTLN---PPGDNRigTVGKPLPGVEVR 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2889 VLDErlrpvpvgmpGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQ 2968
Cdd:cd05907    275 IADD----------GEILVRGPNVMLGYYKNPEATAEALDADGW-------LHTGDLGEIDED---GFLHI--TGRKKDL 332

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 2969 VKLR-GLRIELGEIEAVLAEHDAVESAVVLGVGGSvatALAAYIVPVDGAVE 3019
Cdd:cd05907    333 IITSgGKNISPEPIENALKASPLISQAVVIGDGRP---FLVALIVPDPEALE 381

PRK12492

long-chain-fatty-acid--CoA ligase; Provisional

2566-3062

1.88e-25

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 114.15 E-value: 1.88e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:PRK12492    25 SVVEVFERSCKKFADRPAFSN-LGVTLSYAELERHSAAFAAYLQQHtDLVPGDRIAVQMPNVLQYPIAVFGALRAGLIVV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSG--AVLGLSV---LASGDLPGQEFEWM---RLDD--------------DSVAAEIAA--VP- 2699
Cdd:PRK12492   104 NTNPLYTAREMRHQFKDSGarALVYLNMfgkLVQEVLPDTGIEYLieaKMGDllpaakgwlvntvvDKVKKMVPAyhLPq 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2700 AGPITDAERLGE--------VTAANLAYVIYTSGSTGRPKGVAVTHSGL--------ANFARQESD---RLNAGDN---- 2756
Cdd:PRK12492   184 AVPFKQALRQGRglslkpvpVGLDDIAVLQYTGGTTGLAKGAMLTHGNLvanmlqvrACLSQLGPDgqpLMKEGQEvmia 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2757 PVVLgFASPSFDASVLeYLLATVNEGTLAYRPSEaVGGEVLE----RFIAEHGATHTFLT----PSvLSTMDPTAvpsLR 2828
Cdd:PRK12492   264 PLPL-YHIYAFTANCM-CMMVSGNHNVLITNPRD-IPGFIKElgkwRFSALLGLNTLFVAlmdhPG-FKDLDFSA---LK 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2829 VIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTigiTISSAMRPGDPVRLGG---PIGGVDLMVLDERLRPVPVGMPG 2903
Cdd:PRK12492   337 LTNSGGTALVKATAERWEQLTgcTIVEGYGLTETS---PVASTNPYGELARLGTvgiPVPGTALKVIDDDGNELPLGERG 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2904 ELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtgGLTlEYTGRSDDQVKLRGLRIELGEIEA 2983
Cdd:PRK12492   414 ELCIKGPQVMKGYWQQPEATAEALDAEGW-------FKTGDIAVIDPD----GFV-RIVDRKKDLIIVSGFNVYPNEIED 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2984 VLAEHDAVESAVVLGVGGS-VATALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEP 3062
Cdd:PRK12492   482 VVMAHPKVANCAAIGVPDErSGEAVKLFVVARDPGLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDI 561

caiC

PRK08008

putative crotonobetaine/carnitine-CoA ligase; Validated

2566-3059

2.73e-25

putative crotonobetaine/carnitine-CoA ligase; Validated

Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 113.24 E-value: 2.73e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVV--DGAG--ARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGG 2641
Cdd:PRK08008     8 HLRQMWDDLADVYGHKTALIfeSSGGvvRRYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKIGA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2642 AYVPIDPDYPAERVASMIEDSGAvlGLSVLASGDLPgqEFEWMRLDDDSVAAEIAAVPAG-----PITDAERLGEVTAAN 2716
Cdd:PRK08008    88 IMVPINARLLREESAWILQNSQA--SLLVTSAQFYP--MYRQIQQEDATPLRHICLTRVAlpaddGVSSFTQLKAQQPAT 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2717 LAY-----------VIYTSGSTGRPKGVAVTHSGLaNFARQESD---RLNAGDnpvVLGFASPSFDasvleyllatVNEG 2782
Cdd:PRK08008   164 LCYapplstddtaeILFTSGTTSRPKGVVITHYNL-RFAGYYSAwqcALRDDD---VYLTVMPAFH----------IDCQ 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2783 TLAYRPSEAVGGE--VLERF--------IAEHGATHTFLTPSVLST-MDPTAVPS-----LRVIA---AGGEAVPQPIVD 2843
Cdd:PRK08008   230 CTAAMAAFSAGATfvLLEKYsarafwgqVCKYRATITECIPMMIRTlMVQPPSANdrqhcLREVMfylNLSDQEKDAFEE 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2844 RWApaTELHNLYGPTETTIGItISSamRPGDPVR---LGGPIGGVDLMVLDERLRPVPVGMPGELY---VAGGALSRGYL 2917
Cdd:PRK08008   310 RFG--VRLLTSYGMTETIVGI-IGD--RPGDKRRwpsIGRPGFCYEAEIRDDHNRPLPAGEIGEICikgVPGKTIFKEYY 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2918 DRSGLTAERFTANPYGTAGQRMYRtgdvvrwtpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVL 2997
Cdd:PRK08008   385 LDPKATAKVLEADGWLHTGDTGYV-----------DEEGF-FYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVV 452

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 2998 GVGGSVA-TALAAYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK08008   453 GIKDSIRdEAIKAFVVLNEGEtLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIKKNL 516

PRK08279

long-chain-acyl-CoA synthetase; Validated

1038-1508

3.15e-25

long-chain-acyl-CoA synthetase; Validated

Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 113.82 E-value: 3.15e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQR-DLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIgSVLATW-GVIKSGAAYVP 1115
Cdd:PRK08279    38 SLGDVFEEAaARHPDRPALLFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRP-EYLAAWlGLAKLGAVVAL 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1116 VDPAYPADRIAYMLEDSGATVGITDA-------STRARLGESSCEWV----------DLADLEAEAESGDDITDTERNGs 1178
Cdd:PRK08279   117 LNTQQRGAVLAHSLNLVDAKHLIVGEelveafeEARADLARPPRLWVaggdtlddpeGYEDLAAAAAGAPTTNPASRSG- 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1179 VRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSFDASMFEMAW--AIPAGHTLV 1256
Cdd:PRK08279   196 VTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKAMGGFGGLLRLTPDD-----VLYCCLPLYHNTGGTVAWssVLAAGATLA 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1257 IAPQadFAGDALAtvlerDEVTDMIITPSV--------LATVDP---ERAQYVRnLATgGEACPPELVERWSER-G-RRI 1323
Cdd:PRK08279   271 LRRK--FSASRFW-----DDVRRYRATAFQyigelcryLLNQPPkptDRDHRLR-LMI-GNGLRPDIWDEFQQRfGiPRI 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNCYGPTEATVWAT----------RSRMTAGKPVTI-------GKPvdgftVRVLDGRLHEVPQGVVGELYLSTAGLAR- 1385
Cdd:PRK08279   342 LEFYAASEGNVGFInvfnfdgtvgRVPLWLAHPYAIvkydvdtGEP-----VRDADGRCIKVKPGEVGLLIGRITDRGPf 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1386 -GYlGRPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVG 1464
Cdd:PRK08279   417 dGY-TDPEASEKKILRDVF-KKGDAWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVATTEVENALSGFPGVEEAVVYG 494

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616 1465 VE----STRGGrkhtevVAYLVAKPGATIDSAAVLDEAAQHLAAHMVP 1508
Cdd:PRK08279   495 VEvpgtDGRAG------MAAIVLADGAEFDLAALAAHLYERLPAYAVP 536

MACS_like_3

cd05971

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

13-468

4.49e-25

Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 111.37 E-value: 4.49e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   13 LARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTsdgeaearsrfdd 92
Cdd:cd05971     19 FANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGAS-ALVT------------- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   93 ivdvhvldisspgdaDLDEEEfagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPIT 172
Cdd:cd05971     85 ---------------DGSDDP----------ALIIYTSGTTGPPKGALHAHRVLLGHLPGVQFPFNLFPRDGDLYWTPAD 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  173 -------FDVsvreiFLPIAIGATLVIAEPGRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQT 245
Cdd:cd05971    140 wawigglLDV-----LLPSLYFGVPVLAHRMTKFDPKAALDLMSRYGVTTAFLPPTALKMMRQQGEQLKHAQVKLRAIAT 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  246 GGEaltpPVARDLMV---RLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELY 322
Cdd:cd05971    215 GGE----SLGEELLGwarEQFGVEVNEFYGQTECNLVIGNCSALFPIKPGSMGKPIPGHRVAIVDDNGTPLPPGEVGEIA 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  323 L---GGVQLArGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA 399
Cdd:cd05971    291 VelpDPVAFL-GYWNNPSATEKKMAGDWL--------LTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKH 361

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616  400 PGVLHAAA-AVVDGPGGQQLVGY--LAPADVDVDTVAATTAEL----LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05971    362 PAVLMAAVvGIPDPIRGEIVKAFvvLNPGETPSDALAREIQELvktrLAAHEYPREIEFVNELPRTATGKIRRREL 437

FACL_like_5

cd05924

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

119-466

6.10e-25

Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 109.39 E-value: 6.10e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  119 RPANAAFTLFTSGSTGRPKAVVITH----------RGIANRLAADIEQYDLTARD----VFLYKAPITFDVSVREIFLPI 184
Cdd:cd05924      1 RSADDLYILYTGGTTGMPKGVMWRQedifrmlmggADFGTGEFTPSEDAHKAAAAaagtVMFPAPPLMHGTGSWTAFGGL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  185 AIGATLVIaePGRHGDPVHLADLIRRHGVTVIHFV-PAMLAAFNEVL-GAGVGELTSLRLIQTGGEALTPPVARDLMVRL 262
Cdd:cd05924     81 LGGQTVVL--PDDRFDPEEVWRTIEKHKVTSMTIVgDAMARPLIDALrDAGPYDLSSLFAISSGGALLSPEVKQGLLELV 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  263 PGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSarVLDAALREVPIGVPGELYLG--GVqLARGYAGRPDLTA 340
Cdd:cd05924    159 PNITLVDAFGSSETGFTGSGHSAGSGPETGPFTRANPDTV--VLDDDGRVVPPGSGGVGWIArrGH-IPLGYYGDEAKTA 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  341 ERFV-ADpfgepGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPG---GQ 416
Cdd:cd05924    236 ETFPeVD-----GVRYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAV--YDVLVVGRPDerwGQ 308

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  417 QLVGYLA---PADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRR 466
Cdd:cd05924    309 EVVAVVQlreGAGVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGKADYR 361

PRK13382

bile acid CoA ligase;

1-471

6.11e-25

bile acid CoA ligase;

Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 112.54 E-value: 6.11e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK13382    69 LTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILLLNTSFAGPALAEVVTREGVDTVIYDE 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIVD-VHVLDISSPGDADLDE---EEFAG---PTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAAD 153
Cdd:PRK13382   149 EFSATVDRALADCPQaTRIVAWTDEDHDLTVEvliAAHAGqrpEPTGRKGRVILLTSGTTGTPKGARRSGPGGIGTLKAI 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  154 IEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAM----LAAFNEV 229
Cdd:PRK13382   229 LDRTPWRAEEPTVIVAPMFHAWGFSQLVLAASLACTIVTR---RRFDPEATLDLIDRHRATGLAVVPVMfdriMDLPAEV 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  230 LGAGVGEltSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTihrVTQDD-RVIP--IGTPTRRVSARVL 306
Cdd:PRK13382   306 RNRYSGR--SLRFAAASGSRMRPDVVIAFMDQF-GDVIYNNYNATEAGMIAT---ATPADlRAAPdtAGRPAEGTEIRIL 379

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  307 DAALREVPIGVPGELYLGGVQLARGY-AGRPDLTAERFVAdpfgepgarlyrTGDRARWNRDGEIEYLGRTDFQVKLRGQ 385
Cdd:PRK13382   380 DQDFREVPTGEVGTIFVRNDTQFDGYtSGSTKDFHDGFMA------------SGDVGYLDENGRLFVVGRDDEMIVSGGE 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  386 RLELGEVEAALAAAPGVLHAAAAVVDGPG-GQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSG 461
Cdd:PRK13382   448 NVYPIEVEKTLATHPDVAEAAVIGVDDEQyGQRLAAFVVLKPgasATPETLKQHVRDNLANYKVPRDIVVLDELPRGATG 527

                          490
                   ....*....|
gi 1827387616  462 KVDRRLLPEP 471
Cdd:PRK13382   528 KILRRELQAR 537

AACS_like

cd05968

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...

2569-3059

6.45e-25

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.

Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 112.97 E-value: 6.45e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVV----DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:cd05968     65 QLLDKWLADTRTRPALRwegeDGTSRTLTYGELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIVV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSGAVLglsvLASGDL---PGQEFEWMRLDDDSVAA---------------EIAAVPAGPITDA 2706
Cdd:cd05968    145 PIFSGFGKEAAATRLQDAEAKA----LITADGftrRGREVNLKEEADKACAQcptvekvvvvrhlgnDFTPAKGRDLSYD 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2707 E-------RLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQ---------ESDRLN-AGDNPVVLG----FASP 2765
Cdd:cd05968    221 EeketagdGAERTESEDPLMIIYTSGTTGKPKGTVHVHAGFPLKAAQdmyfqfdlkPGDLLTwFTDLGWMMGpwliFGGL 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2766 SFDASVLEYllatvnEGTlayrPSEAVGGEvLERFIAEHGATHTFLTPSVLSTMDPTA--------VPSLRVIAAGGEAV 2837
Cdd:cd05968    301 ILGATMVLY------DGA----PDHPKADR-LWRMVEDHEITHLGLSPTLIRALKPRGdapvnahdLSSLRVLGSTGEPW 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2838 -PQPIvdRWAPATELH------NLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPvGMPGELYVAGG 2910
Cdd:cd05968    370 nPEPW--NWLFETVGKgrnpiiNYSGGTEISGGILGNVLIKPIKPSSFNGPVPGMKADVLDESGKPAR-PEVGELVLLAP 446

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2911 --ALSRGYLDRSgltaERFTaNPYGTAGQRMYRTGDVVRWtpdtDTGGLTLeYTGRSDDQVKLRGLRIELGEIEAVLAEH 2988
Cdd:cd05968    447 wpGMTRGFWRDE----DRYL-ETYWSRFDNVWVHGDFAYY----DEEGYFY-ILGRSDDTINVAGKRVGPAEIESVLNAH 516

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2989 DAVESAVVLGVGGSV-ATALAAYIVPVDGAVEV----SELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05968    517 PAVLESAAIGVPHPVkGEAIVCFVVLKPGVTPTealaEELMERVADELGKPLSPERILFVKDLPKTRNAKVMRRVI 592

PRK13390

acyl-CoA synthetase; Provisional

1050-1530

7.51e-25

acyl-CoA synthetase; Provisional

Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 111.64 E-value: 7.51e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALIC--DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:PRK13390    11 PDRPAVIVaeTGEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAPEADY 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGDDITDTERNGSVRLTNL---AYLIYTSGSTGRPKAV---- 1200
Cdd:PRK13390    91 IVGDSGARVLVASAALDGLAAKVGADLPLRLSFGGEIDGFGSFEAALAGAGPRLTEQpcgAVMLYSSGTTGFPKGIqpdl 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1201 ---GVSHTGivDFVNSLAKITTGTPEDEpdtrILHVASPSFDASMFEMAWAIPA-GHTLVIAPQADfAGDALATVlERDE 1276
Cdd:PRK13390   171 pgrDVDAPG--DPIVAIARAFYDISESD----IYYSSAPIYHAAPLRWCSMVHAlGGTVVLAKRFD-AQATLGHV-ERYR 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1277 VTDMIITPSVLATV----DPERAQY----VRNLATGGEACPPELVERWSE-RGRRIFNCYGPTEA---TVWATRSRMTag 1344
Cdd:PRK13390   243 ITVTQMVPTMFVRLlkldADVRTRYdvssLRAVIHAAAPCPVDVKHAMIDwLGPIVYEYYSSTEAhgmTFIDSPDWLA-- 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 KPVTIGKPVDGfTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVS-FVADPFgepgarMYATGDLVRVAKGG 1423
Cdd:PRK13390   321 HPGSVGRSVLG-DLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKTAAAqHPAHPF------WTTVGDLGSVDEDG 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1424 NLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVAYLVAKPGATIDSAAVLDEAAQHLA 1503
Cdd:PRK13390   394 YLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIQLVEGIRGSDELARELIDYTRSRIA 473

                          490       500
                   ....*....|....*....|....*..
gi 1827387616 1504 AHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK13390   474 HYKAPRSVEFVDELPRTPTGKLVKGLL 500

PRK05677

long-chain-fatty-acid--CoA ligase; Validated

1051-1530

8.48e-25

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 112.16 E-value: 8.48e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1051 DHPALICDGTEMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK05677    39 DKPAFSNLGKTLTYGELYKLSGAFAAWLQQHtDLKPGDRIAVQLPNVLQYPVAVFGAMRAGLIVVNTNPLYTAREMEHQF 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITDASTrARLGE-----SSCEWV---DLADLEA------------------------EAESGDDIT-----D 1172
Cdd:PRK05677   119 NDSGAKALVCLANM-AHLAEkvlpkTGVKHVivtEVADMLPplkrllinavvkhvkkmvpayhlpQAVKFNDALakgagQ 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1173 TERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDEPDTRI-----LHVASPSFDAsmfeMAW 1247
Cdd:PRK05677   198 PVTEANPQADDVAVLQYTGGTTGVAKGAMLTHRNLVANMLQCRALMGSNLNEGCEILIaplplYHIYAFTFHC----MAM 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1248 AIPAGHTLVIAPQADFagDALATVLERDEVTDMI-ITPSVLATVDPERaqyVRNL--------ATGGEACPPELVERWSE 1318
Cdd:PRK05677   274 MLIGNHNILISNPRDL--PAMVKELGKWKFSGFVgLNTLFVALCNNEA---FRKLdfsalkltLSGGMALQLATAERWKE 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1319 -RGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVS 1397
Cdd:PRK05677   349 vTGCAICEGYGMTETSPVVSVNPSQAIQVGTIGIPVPSTLCKVIDDDGNELPLGEVGELCVKGPQVMKGYWQRPEATDEI 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1398 FVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV 1477
Cdd:PRK05677   429 LDSDGW-------LKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQCAAIGVPDEKSG----EA 497

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 1478 V-AYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK05677   498 IkVFVVVKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRREL 551

PRK07529

AMP-binding domain protein; Validated

2549-3059

1.29e-24

AMP-binding domain protein; Validated

Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 112.36 E-value: 1.29e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2549 AAVELTPVtggPATD-PVTLAELFRAAARRAPDHVAV---VDGAGAR----LTYRELDEASDRLARWLIGRGVGPERAVA 2620
Cdd:PRK07529    11 EAIEAVPL---AARDlPASTYELLSRAAARHPDAPALsflLDADPLDrpetWTYAELLADVTRTANLLHSLGVGPGDVVA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2621 LAIGRSAQLLTAIWAVAKTGGAyVPIDPDYPAERVASMIEDSGA------------------------VLGLSVLASGDL 2676
Cdd:PRK07529    88 FLLPNLPETHFALWGGEAAGIA-NPINPLLEPEQIAELLRAAGAkvlvtlgpfpgtdiwqkvaevlaaLPELRTVVEVDL 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2677 PGQEFEWMRLDDDSVA-----------AEIAAVPAGPITDAERlgeVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR 2745
Cdd:PRK07529   167 ARYLPGPKRLAVPLIRrkaharildfdAELARQPGDRLFSGRP---IGPDDVAAYFHTGGTTGMPKLAQHTHGNEVANAW 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2746 QESDRLNAGDNPVVLgFASPSFDA-SVLEYLLATVNEGT-------LAYRpseavGGEVLERF--IAEHGATHTFLT-PS 2814
Cdd:PRK07529   244 LGALLLGLGPGDTVF-CGLPLFHVnALLVTGLAPLARGAhvvlatpQGYR-----GPGVIANFwkIVERYRINFLSGvPT 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2815 VLSTM-----DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTIGITISSamrPGDPVRLGG-----PI 2882
Cdd:PRK07529   318 VYAALlqvpvDGHDISSLRYALCGAAPLPVEVFRRFEAATgvRIVEGYGLTEATCVSSVNP---PDGERRIGSvglrlPY 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2883 GGVDLMVLDE---RLRPVPVGMPGELYVAGGALSRGYLDrsgltaERFTANPYgtAGQRMYRTGDVVRWTPDtdtGGLTL 2959
Cdd:PRK07529   395 QRVRVVILDDagrYLRDCAVDEVGVLCIAGPNVFSGYLE------AAHNKGLW--LEDGWLNTGDLGRIDAD---GYFWL 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2960 eyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATAL-AAYIVPVDGA-VEVSELKAFAGGRLP---Ay 3034
Cdd:PRK07529   464 --TGRAKDLIIRGGHNIDPAAIEEALLRHPAVALAAAVGRPDAHAGELpVAYVQLKPGAsATEAELLAFARDHIAeraA- 540

                          570       580
                   ....*....|....*....|....*
gi 1827387616 3035 mVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK07529   541 -VPKHVRILDALPKTAVGKIFKPAL 564

PRK06145

acyl-CoA synthetase; Validated

1-468

1.53e-24

acyl-CoA synthetase; Validated

Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 110.75 E-value: 1.53e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK06145    28 ISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVAYILGDAGAKLLLVDE 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDIV-DVHVLDISSPGDADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDL 159
Cdd:PRK06145   108 EFDAIVALETPKIViDAAAQADSRRLAQGGLEIPPQAAVAPTDLVRLMYTSGTTDRPKGVMHSYGNLHWKSIDHVIALGL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARDVFLYKAPItfdVSVREIFLP----IAIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVG 235
Cdd:PRK06145   188 TASERLLVVGPL---YHVGAFDLPgiavLWVGGTLRIH---REFDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRF 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  236 ELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQD-DRVIPIGTPTRRVSARVLDAALREVP 314
Cdd:PRK06145   262 DLDSLAWCIGGGEKTPESRIRDFTRVFTRARYIDAYGLTETCSGDTLMEAGREiEKIGSTGRALAHVEIRIADGAGRWLP 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  315 IGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA 394
Cdd:PRK06145   342 PNMKGEICMRGPKVTKGYWKDPEKTAEAFYGDWF--------RSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVER 413

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616  395 ALAAAPGVLHAAA-AVVDGPGGQQLVG--YLAP-ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK06145   414 VIYELPEVAEAAViGVHDDRWGERITAvvVLNPgATLTLEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVL 491

PRK08315

AMP-binding domain protein; Validated

2566-3056

1.59e-24

AMP-binding domain protein; Validated

Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 111.44 E-value: 1.59e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVD-GAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:PRK08315    17 TIGQLLDRTAARYPDREALVYrDQGLRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPEWVLTQFATAKIGAILV 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSGA---------------------VLGLSVLASGDLPGQEFEWMR----LDDDSVA-----AE 2694
Cdd:PRK08315    97 TINPAYRLSELEYALNQSGCkaliaadgfkdsdyvamlyelAPELATCEPGQLQSARLPELRrvifLGDEKHPgmlnfDE 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2695 IAAvpAGPITDAERLGEVTAANLAY-VI---YTSGSTGRPKGVAVTHSGLANFARQ--ESDRLNAGDN---PV------- 2758
Cdd:PRK08315   177 LLA--LGRAVDDAELAARQATLDPDdPIniqYTSGTTGFPKGATLTHRNILNNGYFigEAMKLTEEDRlciPVplyhcfg 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2759 -VLG------------FASPSFDAsvlEYLLATVNEgtlayrpseavggevlER----------FIAE--HGATHTFltp 2813
Cdd:PRK08315   255 mVLGnlacvthgatmvYPGEGFDP---LATLAAVEE----------------ERctalygvptmFIAEldHPDFARF--- 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2814 sVLStmdptavpSLRV-IAAGGeavPQPI------VDRWApATELHNLYGPTETTIGITISsamRPGDPVRL-----GGP 2881
Cdd:PRK08315   313 -DLS--------SLRTgIMAGS---PCPIevmkrvIDKMH-MSEVTIAYGMTETSPVSTQT---RTDDPLEKrvttvGRA 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2882 IGGVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqRMYRTGDVVrwTPDTDtGGLTLe 2960
Cdd:PRK08315   377 LPHLEVKIVDpETGETVPRGEQGELCTRGYSVMKGYWNDPEKTAEAIDAD-------GWMHTGDLA--VMDEE-GYVNI- 445

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2961 yTGRSDDQVkLRGlrielG------EIEAVLAEHDAVESAVVLGV-----GgsvaTALAAYIVPVDGA-VEVSELKAFAG 3028
Cdd:PRK08315   446 -VGRIKDMI-IRG-----GeniyprEIEEFLYTHPKIQDVQVVGVpdekyG----EEVCAWIILRPGAtLTEEDVRDFCR 514

                          570       580
                   ....*....|....*....|....*...
gi 1827387616 3029 GRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:PRK08315   515 GKIAHYKIPRYIRFVDEFPMTVTGKIQK 542

PRK07470

acyl-CoA synthetase; Validated

4-470

1.62e-24

acyl-CoA synthetase; Validated

Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 110.90 E-value: 1.62e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD-- 81
Cdd:PRK07470    36 REIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVPTNFRQTPDEVAYLAEASGARAMICHADfp 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 -------------------GEAEARSRFDDIVDVHVLDISSPGDADLDEeefagptrpanAAFTLFTSGSTGRPKAVVIT 142
Cdd:PRK07470   116 ehaaavraaspdlthvvaiGGARAGLDYEALVARHLGARVANAAVDHDD-----------PCWFFFTSGTTGRPKAAVLT 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  143 HRG----IANRLAADIEqyDLTARDVFLYKAPITFDVSVREIfLPIAIGATLVIAePGRHGDPVHLADLIRRHGVTVIHF 218
Cdd:PRK07470   185 HGQmafvITNHLADLMP--GTTEQDASLVVAPLSHGAGIHQL-CQVARGAATVLL-PSERFDPAEVWALVERHRVTNLFT 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  219 VPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTI-----HRVTQ--DDRV 291
Cdd:PRK07470   261 VPTILKMLVEHPAVDRYDHSSLRYVIYAGAPMYRADQKRALAKL-GKVLVQYFGLGEVTGNITVlppalHDAEDgpDARI 339

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  292 IPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIE 371
Cdd:PRK07470   340 GTCGFERTGMEVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNPEANAKAFRDGWF--------RTGDLGHLDARGFLY 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  372 YLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQqlVGYL-----APADVDVDTVAATTAELLPEYMR 445
Cdd:PRK07470   412 ITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVlGVPDPVWGE--VGVAvcvarDGAPVDEAELLAWLDGKVARYKL 489

                          490       500
                   ....*....|....*....|....*
gi 1827387616  446 PSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK07470   490 PKRFFFWDALPKSGYGKITKKMVRE 514

PRK05691

peptide synthase; Validated

1038-1877

1.70e-24

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 113.72 E-value: 1.70e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQR-DLDPDHPAL--ICD----GTEMDYDEFETRTNAIARALLARGvSPEDVVAVGMERSIGSVLATWGVIKSG 1110
Cdd:PRK05691    10 TLVQALQRRaAQTPDRLALrfLADdpgeGVVLSYRDLDLRARTIAAALQARA-SFGDRAVLLFPSGPDYVAAFFGCLYAG 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1111 AAYVPvdpAYPAD--------RIAYMLEDSGATVGITDASTRARL-------GESSCEWVDLADLEAEaesgddITDTER 1175
Cdd:PRK05691    89 VIAVP---AYPPEsarrhhqeRLLSIIADAEPRLLLTVADLRDSLlqmeelaAANAPELLCVDTLDPA------LAEAWQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1176 NGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIV-----------------DFVNS--------------LAKITTGTPed 1224
Cdd:PRK05691   160 EPALQPDDIAFLQYTSGSTALPKGVQVSHGNLVaneqlirhgfgidlnpdDVIVSwlplyhdmgligglLQPIFSGVP-- 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1225 epdtrILHVASPSFDASMFEMAWAIPA-GHTLVIAPqaDFAgdaLATVLERdevtdmiITPSVLATVDPERAqyvRNLAT 1303
Cdd:PRK05691   238 -----CVLMSPAYFLERPLRWLEAISEyGGTISGGP--DFA---YRLCSER-------VSESALERLDLSRW---RVAYS 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1304 GGEACPPELVERWSER-------GRRIFNCYGPTEATVWATRSRMTAGKP----------------------VTIGKPVD 1354
Cdd:PRK05691   298 GSEPIRQDSLERFAEKfaacgfdPDSFFASYGLAEATLFVSGGRRGQGIPaleldaealarnraepgtgsvlMSCGRSQP 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1355 GFTVRVLD-GRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVAdpfgEPGARMYATGDLvRVAKGGNLEFAGRADH 1433
Cdd:PRK05691   378 GHAVLIVDpQSLEVLGDNRVGEIWASGPSIAHGYWRNPEASAKTFVE----HDGRTWLRTGDL-GFLRDGELFVTGRLKD 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1434 QVKINGQRVELGEIEAVLDAQpgvaqsvvvgVESTRGGRkhteVVAYLVAKPGAT-IDSAAVLDEAAQHL---------- 1502
Cdd:PRK05691   453 MLIVRGHNLYPQDIEKTVERE----------VEVVRKGR----VAAFAVNHQGEEgIGIAAEISRSVQKIlppqaliksi 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1503 ------AAHMVPSQAIVID--EIPLTPAGKLDRAA---------------LPEPHAPEPAEYVAPANPAEDNLARIVAGL 1559
Cdd:PRK05691   519 rqavaeACQEAPSVVLLLNpgALPKTSSGKLQRSAcrlrladgsldsyalFPALQAVEAAQTAASGDELQARIAAIWCEQ 598

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1560 LGEERVSVTESFFALGGDSIMSIQLSSA-AKAAGIHLSPREIFELKTIRA---MAAAAAASGGPV-ALIEELPGGGTGEM 1634
Cdd:PRK05691   599 LKVEQVAADDHFFLLGGNSIAATQVVARlRDELGIDLNLRQLFEAPTLAAfsaAVARQLAGGGAAqAAIARLPRGQALPQ 678

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1635 PLPPVTSWMIEHSEepadfadfSQSLVFNVPASAAV------ADLQTVVEAVAAAHPML-TAVLTRSGDGWTMNAGAGIV 1707
Cdd:PRK05691   679 SLAQNRLWLLWQLD--------PQSAAYNIPGGLHLrgeldeAALRASFQRLVERHESLrTRFYERDGVALQRIDAQGEF 750

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1708 PaVREIDAEGaLDPALVDA------HRELLGAMDPGTGSLLGTAVVN-GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAW 1780
Cdd:PRK05691   751 A-LQRIDLSD-LPEAEREAraaqirEEEARQPFDLEKGPLLRVTLVRlDDEEHQLLVTLHHIVADGWSLNILLDEFSRLY 828

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1781 AQLTSGRPIELRPEATTTRRIAH-----LLAGQVharAREVDYWLEQLPERPTSFGTSADRP--LHRRRDESSLTYVVDD 1853
Cdd:PRK05691   829 AAACQGQTAELAPLPLGYADYGAwqrqwLAQGEA---ARQLAYWKAQLGDEQPVLELATDHPrsARQAHSAARYSLRVDA 905

                          970       980
                   ....*....|....*....|....
gi 1827387616 1854 VAGSILTTVPQAFGSSVDDVLLGA 1877
Cdd:PRK05691   906 SLSEALRGLAQAHQATLFMVLLAA 929

caiC

PRK08008

putative crotonobetaine/carnitine-CoA ligase; Validated

1054-1530

2.99e-24

putative crotonobetaine/carnitine-CoA ligase; Validated

Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 110.16 E-value: 2.99e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1054 ALIC-----DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYM 1128
Cdd:PRK08008    25 ALIFessggVVRRYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESAWI 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1129 LEDSGATVGITDAS-----TRARLGESSC-EWVDLADLEAEAESGddITDTERNGSVRLTNLAY-----------LIYTS 1191
Cdd:PRK08008   105 LQNSQASLLVTSAQfypmyRQIQQEDATPlRHICLTRVALPADDG--VSSFTQLKAQQPATLCYapplstddtaeILFTS 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1192 GSTGRPKAVGVSHTGIVdFVNSLAKITTGTPEDEpdtRILHVAsPSFDASmFEMAWAIPA---GHTLVIAPQAD---FAG 1265
Cdd:PRK08008   183 GTTSRPKGVVITHYNLR-FAGYYSAWQCALRDDD---VYLTVM-PAFHID-CQCTAAMAAfsaGATFVLLEKYSaraFWG 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1266 DAL---ATVlerDEVTDMIITPSVLATVDP-ERAQYVR------NLATggeacppELVERWSER-GRRIFNCYGPTEATV 1334
Cdd:PRK08008   257 QVCkyrATI---TECIPMMIRTLMVQPPSAnDRQHCLRevmfylNLSD-------QEKDAFEERfGVRLLTSYGMTETIV 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 WATRSRMTAGK--PvTIGKPVDGFTVRVLDGRLHEVPQGVVGELYL-STAG--LARGYLGRPGQTAVSFvadpfgEPGAR 1409
Cdd:PRK08008   327 GIIGDRPGDKRrwP-SIGRPGFCYEAEIRDDHNRPLPAGEIGEICIkGVPGktIFKEYYLDPKATAKVL------EADGW 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1410 MYaTGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV-ESTRggrkHTEVVAYLVAKPGAT 1488
Cdd:PRK08008   400 LH-TGDTGYVDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIkDSIR----DEAIKAFVVLNEGET 474

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1827387616 1489 IDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK08008   475 LSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIKKNL 516

PRK07638

acyl-CoA synthetase; Validated

1048-1530

3.26e-24

acyl-CoA synthetase; Validated

Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 109.48 E-value: 3.26e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1048 LDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVvAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:PRK07638    13 LQPNKIAIKENDRVLTYKDWFESVCKVANWLNEKESKNKTI-AILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDELKE 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDASTRARLGESSCEWVDL----ADLEAEAESGDDITDTERNGsvrltnlAYLIYTSGSTGRPKAVGVS 1203
Cdd:PRK07638    92 RLAISNADMIVTERYKLNDLPDEEGRVIEIdewkRMIEKYLPTYAPIENVQNAP-------FYMGFTSGSTGKPKAFLRA 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1204 HTGIVDFVNSLAKITTGTPEDepdtRILhVASpSFDASMFEMAwAIPA---GHTLVIAPQadFAGDALATVLERDEVTDM 1280
Cdd:PRK07638   165 QQSWLHSFDCNVHDFHMKRED----SVL-IAG-TLVHSLFLYG-AISTlyvGQTVHLMRK--FIPNQVLDKLETENISVM 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1281 IITPSVLATVDPERA--QYVRNLATGGEACPPELVERWSER--GRRIFNCYGPTEAT-VWATRSRMTAGKPVTIGKPVDG 1355
Cdd:PRK07638   236 YTVPTMLESLYKENRviENKMKIISSGAKWEAEAKEKIKNIfpYAKLYEFYGASELSfVTALVDEESERRPNSVGRPFHN 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1356 FTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRpgqtavsfvADPFGEPGARMYAT-GDLVRVAKGGNLEFAGRADHQ 1434
Cdd:PRK07638   316 VQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIG---------GVLARELNADGWMTvRDVGYEDEEGFIYIVGREKNM 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1435 VKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLdeaaQHLAAHMVPSQAIVI 1514
Cdd:PRK07638   387 ILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGEK---PVAIIKGSATKQQLKSFCL----QRLSSFKIPKEWHFV 459

                          490
                   ....*....|....*.
gi 1827387616 1515 DEIPLTPAGKLDRAAL 1530
Cdd:PRK07638   460 DEIPYTNSGKIARMEA 475

PRK09274

peptide synthase; Provisional

1043-1505

4.31e-24

peptide synthase; Provisional

Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 109.99 E-value: 4.31e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1043 LAQRDldPDHPALICDGT----------EMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAA 1112
Cdd:PRK09274    15 AAQER--PDQLAVAVPGGrgadgklaydELSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFALTFALFKAGAV 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1113 YVPVDPAYPADRIAYMLEDSG--ATVGITDASTRARLGESSCEWV---------------DLADLEAEAESGD-DITDTE 1174
Cdd:PRK09274    93 PVLVDPGMGIKNLKQCLAEAQpdAFIGIPKAHLARRLFGWGKPSVrrlvtvggrllwggtTLATLLRDGAAAPfPMADLA 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1175 RngsvrlTNLAYLIYTSGSTGRPKAVGVSHTgivdfvNSLAKIT--TGTPEDEPDTRILHVAsPSFdaSMFEMAwaipAG 1252
Cdd:PRK09274   173 P------DDMAAILFTSGSTGTPKGVVYTHG------MFEAQIEalREDYGIEPGEIDLPTF-PLF--ALFGPA----LG 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1253 HTLVIaPQADFAG------DALATVLERDEVTDMIITPSVLATVdperAQY----------VRNLATGGEACPPELVERW 1316
Cdd:PRK09274   234 MTSVI-PDMDPTRpatvdpAKLFAAIERYGVTNLFGSPALLERL----GRYgeangiklpsLRRVISAGAPVPIAVIERF 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1317 SE---RGRRIFNCYGPTEA----------TVWATRSRMTAGKPVTIGKPVDGFTVRVLD---------GRLHEVPQGVVG 1374
Cdd:PRK09274   309 RAmlpPDAEILTPYGATEAlpissiesreILFATRAATDNGAGICVGRPVDGVEVRIIAisdapipewDDALRLATGEIG 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1375 ELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMyatGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQ 1454
Cdd:PRK09274   389 EIVVAGPMVTRSYYNRPEATRLAKIPDGQGDVWHRM---GDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTH 465

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 1455 PGVAQSVVVGVEstrggrKHTEVVAYLV--AKPGATIDSAAVLDEAAQHLAAH 1505
Cdd:PRK09274   466 PGVKRSALVGVG------VPGAQRPVLCveLEPGVACSKSALYQELRALAAAH 512

FAAL

cd05931

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...

1-466

4.68e-24

Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 109.64 E-value: 4.68e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEvAVGIQIDRSVEQVVAIHAVAMAGGHFVPL---DEQLPVDRARYMVRTAGVRLVV 77
Cdd:cd05931     25 LTYAELDRRARAIAARLQAVGKPGD-RVLLLAPPGLDFVAAFLGCLYAGAIAVPLpppTPGRHAERLAAILADAGPRVVL 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   78 VTSDGEAEAR---SRFDDIVDVHVLDISSPGDADLDEEEFAGPTrPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADI 154
Cdd:cd05931    104 TTAAALAAVRafaASRPAAGTPRLLVVDLLPDTSAADWPPPSPD-PDDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIR 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  155 EQYDLTARDVFLYKAPITFDVS-VREIFLPIAIGATLVIAEPGRH-GDPVHLADLIRRHGVTVIhFVPAMlaAFNEVLGA 232
Cdd:cd05931    183 RAYGLDPGDVVVSWLPLYHDMGlIGGLLTPLYSGGPSVLMSPAAFlRRPLRWLRLISRYRATIS-AAPNF--AYDLCVRR 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  233 GVGE------LTSLRLIQTGGEaltpPVARDLMVR---------LPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPI--- 294
Cdd:cd05931    260 VRDEdlegldLSSWRVALNGAE----PVRPATLRRfaeafapfgFRPEAFRPSYGLAEATLFVSGGPPGTGPVVLRVdrd 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  295 ----------------------GTPTRRVSARVLDAA-LREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPfGEP 351
Cdd:cd05931    336 alagravavaaddpaarelvscGRPLPDQEVRIVDPEtGRELPDGEVGEIWVRGPSVASGYWGRPEATAETFGALA-ATD 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  352 GARLYRTGDRARWnRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLH---AAAAVVDGPGGQQLVgylAPADVD 428
Cdd:cd05931    415 EGGWLRTGDLGFL-HDGELYITGRLKDLIIVRGRNHYPQDIEATAEEAHPALRpgcVAAFSVPDDGEERLV---VVAEVE 490

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1827387616  429 VDTVAATTAELLPEY---------MRPSA--WVRLDAMPLSRSGKVDRR 466
Cdd:cd05931    491 RGADPADLAAIAAAIraavarehgVAPADvvLVRPGSIPRTSSGKIQRR 539

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

2566-3061

6.04e-24

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 111.55 E-value: 6.04e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAGARLTYRELDEASDRLARwLIGRGVGPERAVALAIGRSAQllTAIWAVAKTGGAYVP 2645
Cdd:PRK08633   616 PLAEAWIDTAKRNWSRLAVADSTGGELSYGKALTGALALAR-LLKRELKDEENVGILLPPSVA--GALANLALLLAGKVP 692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDYPAERVA--SMIEDSGAV-----------LGLSVLASGDLPGQEFEWMrlDD--------DSVAAEIAA--VPAGP 2702
Cdd:PRK08633   693 VNLNYTASEAAlkSAIEQAQIKtvitsrkflekLKNKGFDLELPENVKVIYL--EDlkakiskvDKLTALLAArlLPARL 770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2703 ITdAERLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLG----FASPSFDASVLEYLLat 2778
Cdd:PRK08633   771 LK-RLYGPTFKPDDTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNLRNDDVILSslpfFHSFGLTVTLWLPLL-- 847

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2779 vnEGTLA---YRPSEAVGgevLERFIAEHGATHTFLTPSVLST------MDPTAVPSLRVIAAGGEAVPQPIVDRWAPAT 2849
Cdd:PRK08633   848 --EGIKVvyhPDPTDALG---IAKLVAKHRATILLGTPTFLRLylrnkkLHPLMFASLRLVVAGAEKLKPEVADAFEEKF 922

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2850 ELHNL--YGPTETT--IGITISSAMRPGDPVRLGG-------PIGGVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYL 2917
Cdd:PRK08633   923 GIRILegYGATETSpvASVNLPDVLAADFKRQTGSkegsvgmPLPGVAVRIVDpETFEELPPGEDGLILIGGPQVMKGYL 1002

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2918 DRSGLTAERFTAnpygTAGQRMYRTGDVVRWtpDTDtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEhdavesavVL 2997
Cdd:PRK08633  1003 GDPEKTAEVIKD----IDGIGWYVTGDKGHL--DED-GFLTI--TDRYSRFAKIGGEMVPLGAVEEELAK--------AL 1065

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 2998 GVGGSVataLAAYIVP------------VDGAVEVSELK-AFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK08633  1066 GGEEVV---FAVTAVPdekkgeklvvlhTCGAEDVEELKrAIKESGLPNLWKPSRYFKVEALPLLGSGKLDLKGLKE 1139

PRK07514

malonyl-CoA synthase; Validated

2567-3061

6.99e-24

malonyl-CoA synthase; Validated

Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 108.81 E-value: 6.99e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2567 LAELFRAAARRaPDHVAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPI 2646
Cdd:PRK07514     5 LFDALRAAFAD-RDAPFIETPDGLRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGAVFLPL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2647 DPDYPAERVASMIEDSGAvlGLSVLASGDlpgqeFEWMR-------------LDDD---SVAAEIAAVPAgPITDAERlg 2710
Cdd:PRK07514    84 NTAYTLAELDYFIGDAEP--ALVVCDPAN-----FAWLSkiaaaagaphvetLDADgtgSLLEAAAAAPD-DFETVPR-- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2711 evTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR--QESDRLNAGD------------------NPVVLGFAS----PS 2766
Cdd:PRK07514   154 --GADDLAAILYTSGTTGRSKGAMLSHGNLLSNALtlVDYWRFTPDDvlihalpifhthglfvatNVALLAGASmiflPK 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2767 FDAS-VLEYL-LATVNEGTlayrPSEAVggevleRFIAEHGathtfLTPSVLSTMdptavpslRVIAAGG---------- 2834
Cdd:PRK07514   232 FDPDaVLALMpRATVMMGV----PTFYT------RLLQEPR-----LTREAAAHM--------RLFISGSapllaethre 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2835 --EAVPQPIVDRwapatelhnlYGPTETtigITISSamRPGDPVRLGGPIG----GVDLMVLD-ERLRPVPVGMPGELYV 2907
Cdd:PRK07514   289 fqERTGHAILER----------YGMTET---NMNTS--NPYDGERRAGTVGfplpGVSLRVTDpETGAELPPGEIGMIEV 353

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2908 AGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAE 2987
Cdd:PRK07514   354 KGPNVFKGYWRMPEKTAEEFRADGF-------FITGDLGKIDER---GYVHI--VGRGKDLIISGGYNVYPKEVEGEIDE 421

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2988 HDAV-ESAVVlGVG----GSVATALaayIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK07514   422 LPGVvESAVI-GVPhpdfGEGVTAV---VVPKPGAaLDEAAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLRE 497

FADD10

cd17635

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...

127-465

1.05e-23

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.

Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 105.42 E-value: 1.05e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  127 LFTSGSTGRPKAVVITHRG-IANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepGRHGDPVHLA 205
Cdd:cd17635      7 IFTSGTTGEPKAVLLANKTfFAVPDILQKEGLNWVVGDVTYLPLPATHIGGLWWILTCLIHGGLCVTG--GENTTYKSLF 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 DLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEAltpPVARDLMVRL--PGTRLQNQYGPAEASIVVTIH 283
Cdd:cd17635     85 KILTTNAVTTTCLVPTLLSKLVSELKSANATVPSLRLIGYGGSR---AIAADVRFIEatGLTNTAQVYGLSETGTALCLP 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRAR 363
Cdd:cd17635    162 TDDDSIEINAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLIDGWV--------NTGDLGE 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  364 WNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAA-AAVVDGPGGQQLVGYLAPADVDVDTVAA----TTAE 438
Cdd:cd17635    234 RREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECAcYEISDEEFGELVGLAVVASAELDENAIRalkhTIRR 313

                          330       340
                   ....*....|....*....|....*..
gi 1827387616  439 LLPEYMRPSAWVRLDAMPLSRSGKVDR 465
Cdd:cd17635    314 ELEPYARPSTIVIVTDIPRTQSGKVKR 340

BACL_like

cd05929

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...

2574-3059

1.19e-23

Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 107.46 E-value: 1.19e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2574 AARRAPDHVAVVDGAGaRLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAE 2653
Cdd:cd05929      1 LEARDLDRAQVFHQRR-LLLLDVYSIALNRNARAAAAEGVWIADGVYIYLINSILTVFAAAAAWKCGACPAYKSSRAPRA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2654 RVASMIEDSGAVLGLSVLASGDLPGqefewmRLDDDsvAAEIAAVPAGPItDAERLGEvtaanlaYVIYTSGSTGRPKGV 2733
Cdd:cd05929     80 EACAIIEIKAAALVCGLFTGGGALD------GLEDY--EAAEGGSPETPI-EDEAAGW-------KMLYSGGTTGRPKGI 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2734 AVTHSGlanfarqesdrlNAGDNPVVLGFA---SPSFDASvleYLL---------ATVNEGTLAyrpseaVGGEV--LER 2799
Cdd:cd05929    144 KRGLPG------------GPPDNDTLMAAAlgfGPGADSV---YLSpaplyhaapFRWSMTALF------MGGTLvlMEK 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2800 FIAE--------HGATHTFLTPSVLSTMD--PTAVP------SLR-VIAAGGE---AVPQPIVDRWAPAteLHNLYGPTE 2859
Cdd:cd05929    203 FDPEeflrlierYRVTFAQFVPTMFVRLLklPEAVRnaydlsSLKrVIHAAAPcppWVKEQWIDWGGPI--IWEYYGGTE 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2860 TtIGIT-ISSAMRPGDPVRLGGPIGGvDLMVLDERLRPVPVGMPGELYVAGGAlSRGYLDRSGLTAERFTANPYGTagqr 2938
Cdd:cd05929    281 G-QGLTiINGEEWLTHPGSVGRAVLG-KVHILDEDGNEVPPGEIGEVYFANGP-GFEYTNDPEKTAAARNEGGWST---- 353

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2939 myrTGDVVRWtpDTDtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-GGSVATALAAYIVPVDGA 3017
Cdd:cd05929    354 ---LGDVGYL--DED-GYLYL--TDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVpDEELGQRVHAVVQPAPGA 425

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616 3018 VE----VSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05929    426 DAgtalAEELIAFLRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLL 471

PRK05852

fatty acid--CoA ligase family protein;

1-470

1.25e-23

fatty acid--CoA ligase family protein;

Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 108.44 E-value: 1.25e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK05852    44 ISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPIAEQRVRSQAAGARVVLIDA 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGE---AEARSRFDDI-VDVHVLDISSPGDADLDEEEFAGPTRPANA--------AFTLFTSGSTGRPKAVVITHRGIAN 148
Cdd:PRK05852   124 DGPhdrAEPTTRWWPLtVNVGGDSGPSGGTLSVHLDAATEPTPATSTpeglrpddAMIMFTGGTTGLPKMVPWTHANIAS 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  149 RLAADIEQYDLTARDVFLYKAPITFDVSVREIFLP-IAIGATLVIAEPGRHG-----DPVHLADLIRRHGVTVIHFVPAM 222
Cdd:PRK05852   204 SVRAIITGYRLSPRDATVAVMPLYHGHGLIAALLAtLASGGAVLLPARGRFSahtfwDDIKAVGATWYTAVPTIHQILLE 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  223 LAAfNEVLGAGVgelTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRVTQDDR----VIPIGTPT 298
Cdd:PRK05852   284 RAA-TEPSGRKP---AALRFIRSCSAPLTAETAQALQTEF-AAPVVCAFGMTEATHQVTTTQIEGIGQtenpVVSTGLVG 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  299 RRVSA--RVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRT 376
Cdd:PRK05852   359 RSTGAqiRIVGSDGLPLPAGAVGEVWLRGTTVVRGYLGDPTITAANFTDGWL--------RTGDLGSLSAAGDLSIRGRI 430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  377 DFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRL 452
Cdd:PRK05852   431 KELINRGGEKISPERVEGVLASHPNVMEAAVfGVPDQLYGEAVAAVIVPresAPPTAEELVQFCRERLAAFEIPASFQEA 510

                          490
                   ....*....|....*...
gi 1827387616  453 DAMPLSRSGKVDRRLLPE 470
Cdd:PRK05852   511 SGLPHTAKGSLDRRAVAE 528

starter-C_NRPS

cd19533

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases ...

2108-2535

1.27e-23

Pssm-ID: 380456 [Multi-domain] Cd Length: 419 Bit Score: 106.68 E-value: 1.27e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQGLFFQADLantvadHDAIDVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPsGAAVTVVPAEVT 2187
Cdd:cd19533      3 PLTSAQRGVWFAEQL------DPEGSIYNLAEYLEITGPVDLAVLERALRQVIAEAETLRLRFTEEE-GEPYQWIDPYTP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2188 VPWSVIDLRAEDAAslDSRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGAELVVTN-HHLLIDGWSSPLVLADLLSLY- 2265
Cdd:cd19533     76 VPIRHIDLSGDPDP--EGAAQQWMQEDLRKPLPLDNDPLFRHALFTLGDNRHFWYQRvHHIVMDGFSFALFGQRVAEIYt 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2266 --ATGQTfTGSLPGTSGRDFADHARAVATADVEAGIAA-WREVLAPVTEPTLVAP-GHEPSADAPPRDHQFSIDVkvTER 2341
Cdd:cd19533    154 alLKGRP-APPAPFGSFLDLVEEEQAYRQSERFERDRAfWTEQFEDLPEPVSLARrAPGRSLAFLRRTAELPPEL--TRT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2342 LEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPdiEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQ 2421
Cdd:cd19533    231 LLEAAEAHGASWPSFFIALVAAYLHRLTGANDVVLGVPVMGRLG--AAARQTPGMVANTLPLRLTVDPQQTFAELVAQVS 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2422 NDKVKVLDHQQIGLPRLVAQTGLPA----LFDTLAVYESFP--VNVDSVAGIDASSAGGLklvgakTSDAThypLNLSAS 2495
Cdd:cd19533    309 RELRSLLRHQRYRYEDLRRDLGLTGelhpLFGPTVNYMPFDygLDFGGVVGLTHNLSSGP------TNDLS---IFVYDR 379

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1827387616 2496 RRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd19533    380 DDESGLRIDFDANPALYSGEDLARHQERLLRLLEEAAADP 419

PRK13390

acyl-CoA synthetase; Provisional

2575-3059

1.67e-23

acyl-CoA synthetase; Provisional

Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 107.40 E-value: 1.67e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVVDG-AGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAE 2653
Cdd:PRK13390     7 AQIAPDRPAVIVAeTGEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAP 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2654 RVASMIEDSGAVL--------GLSVLASGDLPgqefewMRLD-----DDSVAAEIAAVPAGPitdaeRLGEVTAAnlAYV 2720
Cdd:PRK13390    87 EADYIVGDSGARVlvasaaldGLAAKVGADLP------LRLSfggeiDGFGSFEAALAGAGP-----RLTEQPCG--AVM 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2721 IYTSGSTGRPKGVAvthsglANFARQESDRlnAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPS--EAVGGEVL- 2797
Cdd:PRK13390   154 LYSSGTTGFPKGIQ------PDLPGRDVDA--PGDPIVAIARAFYDISESDIYYSSAPIYHAAPLRWCSmvHALGGTVVl 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2798 -ERFIAEHGATHTFLTPSVLSTMDPTA----------------VPSLRVIAAGGEAVP----QPIVDRWAPAteLHNLYG 2856
Cdd:PRK13390   226 aKRFDAQATLGHVERYRITVTQMVPTMfvrllkldadvrtrydVSSLRAVIHAAAPCPvdvkHAMIDWLGPI--VYEYYS 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2857 PTETTIGITISSAMRPGDPVRLGGPIGGvDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAE-RFTANPYgta 2935
Cdd:PRK13390   304 STEAHGMTFIDSPDWLAHPGSVGRSVLG-DLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKTAAaQHPAHPF--- 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2936 gqrmyrtgdvvrWTPDTDTGGLT----LEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATAL 3007
Cdd:PRK13390   380 ------------WTTVGDLGSVDedgyLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPdpemGEQVKAV 447

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 3008 AAYIVPVDGAVEVS-ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK13390   448 IQLVEGIRGSDELArELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLL 500

PRK06087

medium-chain fatty-acid--CoA ligase;

124-468

2.11e-23

medium-chain fatty-acid--CoA ligase;

Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 107.91 E-value: 2.11e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  124 AFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVS-VREIFLPIAIGATLVIAEpgrHGDPV 202
Cdd:PRK06087   190 AAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQDVFMMPAPLGHATGfLHGVTAPFLIGARSVLLD---IFTPD 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  203 HLADLIRRHGVTVIH----FVPAMLaafNEVLGAGVgELTSLRLIQTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASi 278
Cdd:PRK06087   267 ACLALLEQQRCTCMLgatpFIYDLL---NLLEKQPA-DLSALRFFLCGGTTIPKKVARECQQR--GIKLLSVYGSTESS- 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  279 vvtIHRVTQDDRVIPI-----GTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepga 353
Cdd:PRK06087   340 ---PHAVVNLDDPLSRfmhtdGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLDEPELTARALDEEGW----- 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  354 rlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGYLAPAD-VDV 429
Cdd:PRK06087   412 --YYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKI--HDACVVAMPDerlGERSCAYVVLKApHHS 487

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1827387616  430 DTVAATTAEL----LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK06087   488 LTLEEVVAFFsrkrVAKYKYPEHIVVIDKLPRTASGKIQKFLL 530

VL_LC_FACS_like

cd05907

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...

1-447

2.70e-23

Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 106.14 E-value: 2.70e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVts 80
Cdd:cd05907      6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKALFV-- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 dgeaearsrfDDIVDVHVLdisspgdadldeeefagptrpanaaftLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:cd05907     84 ----------EDPDDLATI---------------------------IYTSGTTGRPKGVMLSHRNILSNALALAERLPAT 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPITFDVSVREI-FLPIAIGATLVIAEPgrhgDPVHLADLiRRHGVTVIHFVPAML-AAFNEVLGAGVGELT 238
Cdd:cd05907    127 EGDRHLSFLPLAHVFERRAGlYVPLLAGARIYFASS----AETLLDDL-SEVRPTVFLAVPRVWeKVYAAIKVKAVPGLK 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 ----------SLRLIQTGGEALTPPVARdlMVRLPGTRLQNQYGPAEASIVVTIHRVtQDDRVIPIGTPTRRVSARvlda 308
Cdd:cd05907    202 rklfdlavggRLRFAASGGAPLPAELLH--FFRALGIPVYEGYGLTETSAVVTLNPP-GDNRIGTVGKPLPGVEVR---- 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  309 alrevpIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRT-DFQVKLRGQRL 387
Cdd:cd05907    275 ------IADDGEILVRGPNVMLGYYKNPEATAEALDADGW-------LHTGDLGEIDEDGFLHITGRKkDLIITSGGKNI 341

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  388 ELGEVEAALAAAPGVlhAAAAVVdgpgGQQLVGYLAPADVDVDTVAATTAELLPEYMRPS 447
Cdd:cd05907    342 SPEPIENALKASPLI--SQAVVI----GDGRPFLVALIVPDPEALEAWAEEHGIAYTDVA 395

C_PKS-NRPS

cd20483

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2108-2534

2.71e-23

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHXXXD motif. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380471 [Multi-domain] Cd Length: 430 Bit Score: 105.81 E-value: 2.71e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQGLFFqadLANTVADHDAIDVYVtqtVLSLTGDVDPGRLRSALSELLARQRVLRSGFVrlpSGA--AVTVVPAE 2185
Cdd:cd20483      3 PMSTFQRRLWF---LHNFLEDKTFLNLLL---VCHIKGKPDVNLLQKALSELVRRHEVLRTAYF---EGDdfGEQQVLDD 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2186 VTVPWSVIDL--RAEDAASLDSRVEEVlateRTNPFDMAKPPLIRVVLVE-HGDGAELVVTNHHLLIDGWSSPLVLADLL 2262
Cdd:cd20483     74 PSFHLIVIDLseAADPEAALDQLVRNL----RRQELDIEEGEVIRGWLVKlPDEEFALVLASHHIAWDRGSSKSIFEQFT 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2263 SLY----ATGQTFTGSLPGTSGRDFAD-HARAVATADVEAGIAAWREVL--APVTEPTLvapghePSA--DAPPRD---- 2329
Cdd:cd20483    150 ALYdalrAGRDLATVPPPPVQYIDFTLwHNALLQSPLVQPLLDFWKEKLegIPDASKLL------PFAkaERPPVKdyer 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2330 --HQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAeTVSGRSPDIEgMESMVGMFINTIPAVVDV 2407
Cdd:cd20483    224 stVEATLDKELLARMKRICAQHAVTPFMFLLAAFRAFLYRYTEDEDLTIG-MVDGDRPHPD-FDDLVGFFVNMLPIRCRM 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2408 NPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLPAlfDTlavyESFP-----VNVDSVAGIDASSAGGLKLVGAKT 2482
Cdd:cd20483    302 DCDMSFDDLLESTKTTCLEAYEHSAVPFDYIVDALDVPR--ST----SHFPigqiaVNYQVHGKFPEYDTGDFKFTDYDH 375

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 2483 SDA-THYPLNLSASRRGA-ELALKLKYLPTAFAPEQVAVFADV-LTGLLGAIADH 2534
Cdd:cd20483    376 YDIpTACDIALEAEEDPDgGLDLRLEFSTTLYDSADMERFLDNfVTFLTSVIRDH 430

LCL_NRPS

cd19538

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; ...

2108-2439

3.17e-23

Pssm-ID: 380461 [Multi-domain] Cd Length: 432 Bit Score: 105.81 E-value: 3.17e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQGLFFQADLANTVAdhdaidVYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRsgfvrlpsgaavTVVPAEVT 2187
Cdd:cd19538      3 PLSFAQRRLWFLHQLEGPSA------TYNIPLVIKLKGKLDVQALQQALYDVVERHESLR------------TVFPEEDG 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2188 VPWSVIdlRAEDAASLD--------SRVEEVLATERTNPFDMAKPPLIRVVLVEHGDGAE-LVVTNHHLLIDGWS-SPLv 2257
Cdd:cd19538     65 VPYQLI--LEEDEATPKleikevdeEELESEINEAVRYPFDLSEEPPFRATLFELGENEHvLLLLLHHIAADGWSlAPL- 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2258 LADLLSLY---ATGQT--FTgSLPgtsgRDFADHA---------RAVATADVEAGIAAWREVLApvteptlvapgHEPSA 2323
Cdd:cd19538    142 TRDLSKAYrarCKGEApeLA-PLP----VQYADYAlwqqellgdESDPDSLIARQLAYWKKQLA-----------GLPDE 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2324 DAPPRDHQ-------------FSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGTRTVTFAETVSGRSPDieGM 2390
Cdd:cd19538    206 IELPTDYPrpaessyeggtltFEIDSELHQQLLQLAKDNNVTLFMVLQAGFAALLTRLGAGTDIPIGSPVAGRNDD--SL 283

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1827387616 2391 ESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLV 2439
Cdd:cd19538    284 EDLVGFFVNTLVLRTDTSGNPSFRELLERVKETNLEAYEHQDIPFERLV 332

beta-lac_NRPS

cd19547

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis ...

572-914

5.13e-23

Pssm-ID: 380469 [Multi-domain] Cd Length: 422 Bit Score: 105.09 E-value: 5.13e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  572 PLSRAQRRMWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYP-SVGAAPVQDVLP-VAVAREQL 649
Cdd:cd19547      3 PLAPMQEGMLFRGLFWPDSDAYFNQNVLELVGGTDEDVLREAWRRVADRYEILRTGFTwRDRAEPLQYVRDdLAPPWALL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  650 DW------READSVESLV---RSTTEGFDvstQMPL-RGRFHRDGAGLHVAL-TMHHIAMDGQSIPVLARDLMSAYAARA 718
Cdd:cd19547     83 DWsgedpdRRAELLERLLaddRAAGLSLA---DCPLyRLTLVRLGGGRHYLLwSHHHILLDGWCLSLIWGDVFRVYEELA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  719 EGRTGGL-PVLdvQYADYALWQQSVLGDADdetsvlgEQLSHWRRVLAGLPAV--TDLPMDRPrpavlgTAGATVTVEFD 795
Cdd:cd19547    160 HGREPQLsPCR--PYRDYVRWIRARTAQSE-------ESERFWREYLRDLTPSpfSTAPADRE------GEFDTVVHEFP 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  796 DDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIGTPVAGRnDPAL---EELIGMFVNTLLLRTQVDPGHSVg 872
Cdd:cd19547    225 EQLTRLVNEAARGYGVTTNAISQAAWSMLLALQTGARDVVHGLTIAGR-PPELegsEHMVGIFINTIPLRIRLDPDQTV- 302

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1827387616  873 dllgnvrTTVLDAFANDqvqfdelieaLAPERSSSHQPLAQI 914
Cdd:cd19547    303 -------TGLLETIHRD----------LATTAAHGHVPLAQI 327

OSB_CoA_lg

cd05912

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...

1064-1530

6.38e-23

Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 104.35 E-value: 6.38e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVgitdast 1143
Cdd:cd05912      4 FAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVKL------- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 rarlgesscewvdladleaeaesgDDItdterngsvrltnlAYLIYTSGSTGRPKAVgvshtgIVDFVNSLA-----KIT 1218
Cdd:cd05912     77 ------------------------DDI--------------ATIMYTSGTTGKPKGV------QQTFGNHWWsaigsALN 112

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1219 TGTPEDepdTRILhVASPSFDASMFE-MAWAIPAGHTLVIAPQadFAGDALATVLERDEVTDMIITPSVL---ATVDPER 1294
Cdd:cd05912    113 LGLTED---DNWL-CALPLFHISGLSiLMRSVIYGMTVYLVDK--FDAEQVLHLINSGKVTIISVVPTMLqrlLEILGEG 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1295 AQY-VRNLATGGEACPPELVERWSERGRRIFNCYGPTEAT--VWATRSRMTAGKPVTIGKPVDGFTVRVLDgrlHEVPQG 1371
Cdd:cd05912    187 YPNnLRCILLGGGPAPKPLLEQCKEKGIPVYQSYGMTETCsqIVTLSPEDALNKIGSAGKPLFPVELKIED---DGQPPY 263

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1372 VVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVL 1451
Cdd:cd05912    264 EVGEILLKGPNVTKGYLNRPDATEESFENGWF--------KTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVL 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1452 DAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKpgATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05912    336 LSHPAIKEAGVVGIPDDKWG----QVpVAFVVSE--RPISEEELIAYCSEKLAKYKVPKKIYFVDELPRTASGKLLRHEL 409

caiC

PRK08008

putative crotonobetaine/carnitine-CoA ligase; Validated

2-468

6.71e-23

putative crotonobetaine/carnitine-CoA ligase; Validated

Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 105.92 E-value: 6.71e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSD 81
Cdd:PRK08008    39 SYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESAWILQNSQASLLVTSAQ 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 G-------EAEARSRFDDIVDVHVLDISSPGDADLDEE--------EFAGPTRPANAAFTLFTSGSTGRPKAVVITHrgi 146
Cdd:PRK08008   119 FypmyrqiQQEDATPLRHICLTRVALPADDGVSSFTQLkaqqpatlCYAPPLSTDDTAEILFTSGTTSRPKGVVITH--- 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  147 ANRLAADIE---QYDLTARDVFLYKAP---ITFDVSVReifLPI-AIGATLVIAE--PGRHgdpvhLADLIRRHGVTVIH 217
Cdd:PRK08008   196 YNLRFAGYYsawQCALRDDDVYLTVMPafhIDCQCTAA---MAAfSAGATFVLLEkySARA-----FWGQVCKYRATITE 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  218 FVPAMLAAFnevlgagvgeltslrliqtggeALTPPVA-------RDLMVRLP-------------GTRLQNQYGPAEaS 277
Cdd:PRK08008   268 CIPMMIRTL----------------------MVQPPSAndrqhclREVMFYLNlsdqekdafeerfGVRLLTSYGMTE-T 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  278 IVVTIHRVTQDDRVIP-IGTPTRRVSARVLDAALREVPIGVPGELYLGGV---QLARGYAGRPDLTAERFvadpfgEPGA 353
Cdd:PRK08008   325 IVGIIGDRPGDKRRWPsIGRPGFCYEAEIRDDHNRPLPAGEIGEICIKGVpgkTIFKEYYLDPKATAKVL------EADG 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  354 RLYrTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVG---YLAP-ADVDV 429
Cdd:PRK08008   399 WLH-TGDTGYVDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKafvVLNEgETLSE 477

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1827387616  430 DTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK08008   478 EEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIKKNL 516

FAA1

COG1022

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

1-375

7.67e-23

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 106.34 E-value: 7.67e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVtS 80
Cdd:COG1022     41 LTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLAILAAGAVTVPIYPTSSAEEVAYILNDSGAKVLFV-E 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGE-----AEARSRFDDIVDVHVLD---------------ISSPGDADLDEEEFAGPTRPANAA--FTL-FTSGSTGRPK 137
Cdd:COG1022    120 DQEqldklLEVRDELPSLRHIVVLDprglrddprllsldeLLALGREVADPAELEARRAAVKPDdlATIiYTSGTTGRPK 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  138 AVVITHRGIANRLAADIEQYDLTARDVFLykapitfdvsvreIFLP-------------IAIGATLVIAEpgrhgDPVHL 204
Cdd:COG1022    200 GVMLTHRNLLSNARALLERLPLGPGDRTL-------------SFLPlahvfertvsyyaLAAGATVAFAE-----SPDTL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  205 ADLIRRHGVTVIHFVPAML-------------------AAFNEVLGAGV--------GELTS------------------ 239
Cdd:COG1022    262 AEDLREVKPTFMLAVPRVWekvyagiqakaeeagglkrKLFRWALAVGRryararlaGKSPSlllrlkhaladklvfskl 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 -------LRLIQTGGEALTPPVARdlMVRLPGTRLQNQYGPAEASIVVTIHRvtqDDRVIP--IGTPTRRVsarvldaal 310
Cdd:COG1022    342 realggrLRFAVSGGAALGPELAR--FFRALGIPVLEGYGLTETSPVITVNR---PGDNRIgtVGPPLPGV--------- 407

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616  311 rEVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGR 375
Cdd:COG1022    408 -EVKIAEDGEILVRGPNVMKGYYKNPEATAEAFDADGW-------LHTGDIGELDEDGFLRITGR 464

LC_FACS_like

cd17640

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...

2590-3013

9.82e-23

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 104.75 E-value: 9.82e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2590 ARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLs 2669
Cdd:cd17640      4 KRITYKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVALV- 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2670 vlasgdlpgqefewmrLDDDSvaaeiaavpagpitdaerlgevtaANLAYVIYTSGSTGRPKGVAVTHsglANFARQESd 2749
Cdd:cd17640     83 ----------------VENDS------------------------DDLATIIYTSGTTGNPKGVMLTH---ANLLHQIR- 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2750 rlnagdnpvvlgfaspsfdaSVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSVLS----TMDPT--- 2822
Cdd:cd17640    119 --------------------SLSDIVPPQPGDRFLSILPIWHSYERSAEYFIFACGCSQAYTSIRTLKddlkRVKPHyiv 178

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2823 AVPSL--------------------------------RVIAAGGEAVPqPIVDRWAPAT--ELHNLYGPTETTigiTISS 2868
Cdd:cd17640    179 SVPRLweslysgiqkqvsksspikqflflfflsggifKFGISGGGALP-PHVDTFFEAIgiEVLNGYGLTETS---PVVS 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2869 AMRPGDPVR--LGGPIGGVDLMVLDERLR-PVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDV 2945
Cdd:cd17640    255 ARRLKCNVRgsVGRPLPGTEIKIVDPEGNvVLPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSDGW-------FNTGDL 327

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 2946 VRWTPDTDtggltLEYTGRSDDQVKLR-GLRIELGEIEAVLAEHDAVESAVVLgvgGSVATALAAYIVP 3013
Cdd:cd17640    328 GWLTCGGE-----LVLTGRAKDTIVLSnGENVEPQPIEEALMRSPFIEQIMVV---GQDQKRLGALIVP 388

PRK08279

long-chain-acyl-CoA synthetase; Validated

2564-3059

1.40e-22

long-chain-acyl-CoA synthetase; Validated

Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 105.73 E-value: 1.40e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGay 2643
Cdd:PRK08279    36 KRSLGDVFEEAAARHPDRPALLFE-DQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGA-- 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2644 vpidpdypaerVASMIEDS--GAVLG--LSVL-----------------ASGDLPGQEFEWM--------RLDDDSVAAE 2694
Cdd:PRK08279   113 -----------VVALLNTQqrGAVLAhsLNLVdakhlivgeelveafeeARADLARPPRLWVaggdtlddPEGYEDLAAA 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2695 IAAVPAGPITDAERlgeVTAANLAYVIYTSGSTGRPKGVAVTH-------SGLANFAR-QESDRL--------NAGDNpV 2758
Cdd:PRK08279   182 AAGAPTTNPASRSG---VTAKDTAFYIYTSGTTGLPKAAVMSHmrwlkamGGFGGLLRlTPDDVLycclplyhNTGGT-V 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2759 VLGfaspsfdaSVLeyllatVNEGTLAYRPSEAVGgevleRF---IAEHGATH--------TFLTPSVLSTMDptAVPSL 2827
Cdd:PRK08279   258 AWS--------SVL------AAGATLALRRKFSAS-----RFwddVRRYRATAfqyigelcRYLLNQPPKPTD--RDHRL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2828 RVIAAGGE------------AVPQpIVDRWApATE----LHNLYGpTETTIGITISSAMRP----------GDPVRlgGP 2881
Cdd:PRK08279   317 RLMIGNGLrpdiwdefqqrfGIPR-ILEFYA-ASEgnvgFINVFN-FDGTVGRVPLWLAHPyaivkydvdtGEPVR--DA 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2882 IGgvdlmvldeRLRPVPVGMPGELYVAGGALSR--GYLDRSGlTAERFTANPYgTAGQRMYRTGDVVRwtpdtDTGGLTL 2959
Cdd:PRK08279   392 DG---------RCIKVKPGEVGLLIGRITDRGPfdGYTDPEA-SEKKILRDVF-KKGDAWFNTGDLMR-----DDGFGHA 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2960 EYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV--GGSVATALAAYIVPVDGA-VEVSELKAFAGGRLPAYMV 3036
Cdd:PRK08279   456 QFVDRLGDTFRWKGENVATTEVENALSGFPGVEEAVVYGVevPGTDGRAGMAAIVLADGAeFDLAALAAHLYERLPAYAV 535

                          570       580
                   ....*....|....*....|...
gi 1827387616 3037 PSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK08279   536 PLFVRLVPELETTGTFKYRKVDL 558

PRK04319

acetyl-CoA synthetase; Provisional

1051-1527

1.62e-22

acetyl-CoA synthetase; Provisional

Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 104.98 E-value: 1.62e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1051 DHPALICDGTEMD----YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIA 1126
Cdd:PRK04319    59 DKVALRYLDASRKekytYKELKELSNKFANVLKELGVEKGDRVFIFMPRIPELYFALLGALKNGAIVGPLFEAFMEEAVR 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1127 YMLEDSGATVGITDASTRARL--------------GESSCEWVDLADLEAEAESGDDITDTErngSVRLTNLAYLIYTSG 1192
Cdd:PRK04319   139 DRLEDSEAKVLITTPALLERKpaddlpslkhvllvGEDVEEGPGTLDFNALMEQASDEFDIE---WTDREDGAILHYTSG 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1193 STGRPKAVGVSHTGIVdfvnsLAKITTGTPED-EPDTRILHVASPSFDASMfemAWAIPA----GHTLVIApQADFAGDA 1267
Cdd:PRK04319   216 STGKPKGVLHVHNAML-----QHYQTGKYVLDlHEDDVYWCTADPGWVTGT---SYGIFApwlnGATNVID-GGRFSPER 286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1268 LATVLERDEVTDMIITPSVL-----ATVDPeRAQY----VRNLATGGEACPPELVeRWSER--GRRIFNCYGPTEatvwa 1336
Cdd:PRK04319   287 WYRILEDYKVTVWYTAPTAIrmlmgAGDDL-VKKYdlssLRHILSVGEPLNPEVV-RWGMKvfGLPIHDNWWMTE----- 359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1337 TRSRMTAG------KPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTA--GLARGYLGRPGQTAVSFVADpfgepga 1408
Cdd:PRK04319   360 TGGIMIANypamdiKPGSMGKPLPGIEAAIVDDQGNELPPNRMGNLAIKKGwpSMMRGIWNNPEKYESYFAGD------- 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1409 rMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV-ESTRGgrkhtEVV-AYLVAKPG 1486
Cdd:PRK04319   433 -WYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAVAEAGVIGKpDPVRG-----EIIkAFVALRPG 506

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 1487 ATIDSA---AVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:PRK04319   507 YEPSEElkeEIRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMR 550

PRK07638

acyl-CoA synthetase; Validated

2566-3059

2.01e-22

acyl-CoA synthetase; Validated

Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 104.09 E-value: 2.01e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDGAgARLTYRELDEASDRLARWLIGRGVGPERaVALAIGRSAQLLTAIWAVAKTGGAYVP 2645
Cdd:PRK07638     2 GITKEYKKHASLQPNKIAIKEND-RVLTYKDWFESVCKVANWLNEKESKNKT-IAILLENRIEFLQLFAGAAMAGWTCVP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 IDPDY-PAERVASMIEDSGAVLGLSVLASGDLPGQEF------EWMRLdddsvaAEIAAVPAGPITDAERlgevtaaNLA 2718
Cdd:PRK07638    80 LDIKWkQDELKERLAISNADMIVTERYKLNDLPDEEGrvieidEWKRM------IEKYLPTYAPIENVQN-------APF 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2719 YVIYTSGSTGRPKGVAVTH-SGLANFARQESD-RLNAGDNPVVLGFASPSFdasvleYLLATVNegTLAyrpseaVGGEV 2796
Cdd:PRK07638   147 YMGFTSGSTGKPKAFLRAQqSWLHSFDCNVHDfHMKREDSVLIAGTLVHSL------FLYGAIS--TLY------VGQTV 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2797 -LERFIAEHGATHTFLTP--SVLSTMdPTAVPSL-----------RVIAAGG----EAVPQpIVDRWaPATELHNLYGPT 2858
Cdd:PRK07638   213 hLMRKFIPNQVLDKLETEniSVMYTV-PTMLESLykenrvienkmKIISSGAkweaEAKEK-IKNIF-PYAKLYEFYGAS 289

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2859 EttigITISSAMRPGD----PVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDrsgltaerftanpygt 2934
Cdd:PRK07638   290 E----LSFVTALVDEEserrPNSVGRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYII---------------- 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2935 aGQRMYRTGDVVRWTPDTDTGGLTLE----YTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATA 3006
Cdd:PRK07638   350 -GGVLARELNADGWMTVRDVGYEDEEgfiyIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPdsywGEKPVA 428

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 3007 LaayivpVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK07638   429 I------IKGSATKQQLKSFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEA 475

PLN02860

o-succinylbenzoate-CoA ligase

1066-1479

2.64e-22

o-succinylbenzoate-CoA ligase

Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 104.50 E-value: 2.64e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1066 EFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRA 1145
Cdd:PLN02860    37 EFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSFEEAKSAMLLVRPVMLVTDETCSS 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1146 ---RLGESSC---EWVDLADLEAEAESGDDI----TDTERNGSVRLTNLAY--------LI-YTSGSTGRPKAVGVSHTG 1206
Cdd:PLN02860   117 wyeELQNDRLpslMWQVFLESPSSSVFIFLNsfltTEMLKQRALGTTELDYawapddavLIcFTSGTTGRPKGVTISHSA 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1207 IVdfVNSLAKIT-TGTPEDEPdtrILHVAsPSFDASMFEMAWAI-PAGHTLVIAPQadFAGDALATVLERDEVTDMIITP 1284
Cdd:PLN02860   197 LI--VQSLAKIAiVGYGEDDV---YLHTA-PLCHIGGLSSALAMlMVGACHVLLPK--FDAKAALQAIKQHNVTSMITVP 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1285 SVLAT-VDPERA-------QYVRNLATGGEACPPELVERWSE--RGRRIFNCYGPTEATvwATRSRMTAGKPVTIGKPVD 1354
Cdd:PLN02860   269 AMMADlISLTRKsmtwkvfPSVRKILNGGGSLSSRLLPDAKKlfPNAKLFSAYGMTEAC--SSLTFMTLHDPTLESPKQT 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1355 GFTVRVLDGRLHEVPQGV-VG------ELYL-----STAG--LARG------YLGRPGQTAVSFVADPFgepgarmYATG 1414
Cdd:PLN02860   347 LQTVNQTKSSSVHQPQGVcVGkpaphvELKIgldesSRVGriLTRGphvmlgYWGQNSETASVLSNDGW-------LDTG 419

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVA 1479
Cdd:PLN02860   420 DIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGVASVVVVGVPDSRLTEM---VVA 481

FACL_like_4

cd05944

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1183-1530

3.90e-22

Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 101.02 E-value: 3.90e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSF--DASMFEMAWAIPAGHTLVIAPQ 1260
Cdd:cd05944      3 DVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDD-----VLLCGLPLFhvNGSVVTLLTPLASGAHVVLAGP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1261 ADFAGDALA----TVLERDEVTDMIITPSVLATV--DPERAQY--VRNLATGGEACPPELVERWSER-GRRIFNCYGPTE 1331
Cdd:cd05944     78 AGYRNPGLFdnfwKLVERYRITSLSTVPTVYAALlqVPVNADIssLRFAMSGAAPLPVELRARFEDAtGLPVVEGYGLTE 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1332 ATVWATRS-RMTAGKPVTIGKPVDGFTVR--VLDGRLH---EVPQGVVGELYLSTAGLARGYLGRPGQTavsfvaDPFGE 1405
Cdd:cd05944    158 ATCLVAVNpPDGPKRPGSVGLRLPYARVRikVLDGVGRllrDCAPDEVGEICVAGPGVFGGYLYTEGNK------NAFVA 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1406 PGarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAK 1484
Cdd:cd05944    232 DG--WLNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAG----ELpVAYVQLK 305

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616 1485 PGATIDSAAVLDEAAQHLAAH-MVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05944    306 PGAVVEEEELLAWARDHVPERaAVPKHIEVLEELPVTAVGKVFKPAL 352

PRK05677

long-chain-fatty-acid--CoA ligase; Validated

2569-3059

4.44e-22

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 103.69 E-value: 4.44e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2569 ELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPID 2647
Cdd:PRK05677    28 AVLKQSCQRFADKPAFSN-LGKTLTYGELYKLSGAFAAWLQQHtDLKPGDRIAVQLPNVLQYPVAVFGAMRAGLIVVNTN 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2648 PDYPAERVASMIEDSGA-----VLGLSVLASGDLPGQEFEWM-------------RLDDDSVAAEIAA-VPAGPITDAER 2708
Cdd:PRK05677   107 PLYTAREMEHQFNDSGAkalvcLANMAHLAEKVLPKTGVKHVivtevadmlpplkRLLINAVVKHVKKmVPAYHLPQAVK 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2709 LGEVTA--------------ANLAYVIYTSGSTGRPKGVAVTHSGL-ANFARQES---DRLNAGDNPVVlgfaSP----- 2765
Cdd:PRK05677   187 FNDALAkgagqpvteanpqaDDVAVLQYTGGTTGVAKGAMLTHRNLvANMLQCRAlmgSNLNEGCEILI----APlplyh 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2766 --SFDASVLEYLLaTVNEGTLAYRPSEaVGGEVLE----RFIAEHGATHTFLTPSVLSTMDPTAVPSLRVIAAGGEAVPQ 2839
Cdd:PRK05677   263 iyAFTFHCMAMML-IGNHNILISNPRD-LPAMVKElgkwKFSGFVGLNTLFVALCNNEAFRKLDFSALKLTLSGGMALQL 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2840 PIVDRWAPAT--ELHNLYGPTETTIGITIS--SAMRPGDpvrLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRG 2915
Cdd:PRK05677   341 ATAERWKEVTgcAICEGYGMTETSPVVSVNpsQAIQVGT---IGIPVPSTLCKVIDDDGNELPLGEVGELCVKGPQVMKG 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2916 YLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAV 2995
Cdd:PRK05677   418 YWQRPEATDEILDSDGW-------LKTGDIALIQEDG-----YMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQCA 485

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2996 VLGV-GGSVATALAAYIVPVDG-AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK05677   486 AIGVpDEKSGEAIKVFVVVKPGeTLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRREL 551

C_PKS-NRPS_PksJ-like

cd20484

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2144-2535

4.48e-22

Pssm-ID: 380472 [Multi-domain] Cd Length: 430 Bit Score: 102.01 E-value: 4.48e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2144 TGDVDPGRLRSALSELLARQRVLRSGFVRlpsgaaVTVVPAEVTVPWSVIDLRAEDAASLDSrvEEVLATERTN---PFD 2220
Cdd:cd20484     33 SSKLDVEKFKQACQFVLEQHPILKSVIEE------EDGVPFQKIEPSKPLSFQEEDISSLKE--SEIIAYLREKakePFV 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2221 MAKPPLIRVVLVEHGdGAE--LVVTNHHLLIDGWSSPLVLADLLSLYAT---GQTFTGSLPGTSGRDFAD-HARAVATAD 2294
Cdd:cd20484    105 LENGPLMRVHLFSRS-EQEhfVLITIHHIIFDGSSSLTLIHSLLDAYQAllqGKQPTLASSPASYYDFVAwEQDMLAGAE 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2295 VEAGIAAWREVLAPvTEPTLVAPGHEPSADAPP---RDHQFSIDVKVTERLEALARNNSTTMATVVQFAWAMFLSRLTGT 2371
Cdd:cd20484    184 GEEHRAYWKQQLSG-TLPILELPADRPRSSAPSfegQTYTRRLPSELSNQIKSFARSQSINLSTVFLGIFKLLLHRYTGQ 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2372 RTVTFAETVSGRSPdiEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLP------ 2445
Cdd:cd20484    263 EDIIVGMPTMGRPE--ERFDSLIGYFINMLPIRSRILGEETFSDFIRKLQLTVLDGLDHAAYPFPAMVRDLNIPrsqans 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2446 ALFDTLAVYESFpvnvdsvagidaSSAGGLKLVGAKTSDATH------------YPLNLSASRRGAELALKLKYLPTAFA 2513
Cdd:cd20484    341 PVFQVAFFYQNF------------LQSTSLQQFLAEYQDVLSiefvegihqegeYELVLEVYEQEDRFTLNIKYNPDLFD 408

                          410       420
                   ....*....|....*....|..
gi 1827387616 2514 PEQVAVFADVLTGLLGAIADHP 2535
Cdd:cd20484    409 ASTIERMMEHYVKLAEELIANP 430

PRK12583

acyl-CoA synthetase; Provisional

1-465

5.04e-22

acyl-CoA synthetase; Provisional

Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 103.31 E-value: 5.04e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDeqlPVDRAR---YMVRTAGVRLVV 77
Cdd:PRK12583    46 YTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAILVNIN---PAYRASeleYALGQSGVRWVI 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   78 V-----TSD----------------GEAEARSRFDDIVDVHVLDISSPG----------------DADLDEEEfaGPTRP 120
Cdd:PRK12583   123 CadafkTSDyhamlqellpglaegqPGALACERLPELRGVVSLAPAPPPgflawhelqargetvsREALAERQ--ASLDR 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  121 ANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPI--TFDVsVREIFLPIAIGATLVIaePGRH 198
Cdd:PRK12583   201 DDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLGLTEHDRLCVPVPLyhCFGM-VLANLGCMTVGACLVY--PNEA 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  199 GDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASI 278
Cdd:PRK12583   278 FDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFDLSSLRTGIMAGAPCPIEVMRRVMDEMHMAEVQIAYGMTETSP 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  279 VvtIHRVTQDD----RVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgar 354
Cdd:PRK12583   358 V--SLQTTAADdlerRVETVGRTQPHLEVKVVDPDGATVPRGEIGELCTRGYSVMKGYWNNPEATAESIDEDGW------ 429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  355 lYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPG---GQQLVGY--LAPADvdv 429
Cdd:PRK12583   430 -MHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAV--ADVQVFGVPDekyGEEIVAWvrLHPGH--- 503

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616  430 dtvAATTAEL------------LPEYMRpsawvRLDAMPLSRSGKVDR 465
Cdd:PRK12583   504 ---AASEEELrefckariahfkVPRYFR-----FVDEFPMTVTGKVQK 543

AACS_like

cd05968

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...

5-468

5.37e-22

Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 103.72 E-value: 5.37e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLvVVTSDG-- 82
Cdd:cd05968     96 ELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIVVPIFSGFGKEAAATRLQDAEAKA-LITADGft 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   83 ----------EAEARSRFDDIVDvHVL--------DISSPGDADLDEEEFAGP------TRPANAAFTLFTSGSTGRPKA 138
Cdd:cd05968    175 rrgrevnlkeEADKACAQCPTVE-KVVvvrhlgndFTPAKGRDLSYDEEKETAgdgaerTESEDPLMIIYTSGTTGKPKG 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  139 VVITHRGIANRLAADIE-QYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAE--PGrHGDPVHLADLIRRHGVTV 215
Cdd:cd05968    254 TVHVHAGFPLKAAQDMYfQFDLKPGDLLTWFTDLGWMMGPWLIFGGLILGATMVLYDgaPD-HPKADRLWRMVEDHEITH 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  216 IHFVPAMLAAFNEVLGAGVG--ELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQ--NQYGPAEASIVVTIHRVTQDDRV 291
Cdd:cd05968    333 LGLSPTLIRALKPRGDAPVNahDLSSLRVLGSTGEPWNPEPWNWLFETVGKGRNPiiNYSGGTEISGGILGNVLIKPIKP 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  292 IPIGTPTRRVSARVLDAALREVPIGVpGELYLGG--VQLARGYAGRPDltaeRFVaDPFGEPGARLYRTGDRARWNRDGE 369
Cdd:cd05968    413 SSFNGPVPGMKADVLDESGKPARPEV-GELVLLApwPGMTRGFWRDED----RYL-ETYWSRFDNVWVHGDFAYYDEEGY 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  370 IEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGP-GGQQLVGY------LAPADVDVDTVAATTAELLPE 442
Cdd:cd05968    487 FYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHPvKGEAIVCFvvlkpgVTPTEALAEELMERVADELGK 566

                          490       500
                   ....*....|....*....|....*.
gi 1827387616  443 YMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05968    567 PLSPERILFVKDLPKTRNAKVMRRVI 592

C_PKS-NRPS

cd19532

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2143-2445

7.25e-22

Pssm-ID: 380455 [Multi-domain] Cd Length: 421 Bit Score: 101.38 E-value: 7.25e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2143 LTGDVDPGRLRSALSELLARQRVLRSGF-VRLPSGAAVTVVPAEvtvpwSVIDLRAEDAASlDSRVEEVLATERTNPFDM 2221
Cdd:cd19532     32 LTGPLDVARLERAVRAVGQRHEALRTCFfTDPEDGEPMQGVLAS-----SPLRLEHVQISD-EAEVEEEFERLKNHVYDL 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2222 AKPPLIRVVLVEHGDGA-ELVVTNHHLLIDGWSSPLVLADLLSLYAtGQTftgSLPGTSG-RDFADHARavatADVEAG- 2298
Cdd:cd19532    106 ESGETMRIVLLSLSPTEhYLIFGYHHIAMDGVSFQIFLRDLERAYN-GQP---LLPPPLQyLDFAARQR----QDYESGa 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2299 ----IAAWREVLAPVTE--PTLvapghePSADAPPR------DH---QFSIDVKVTERLEALARNNSttmATVVQF---A 2360
Cdd:cd19532    178 ldedLAYWKSEFSTLPEplPLL------PFAKVKSRppltryDThtaERRLDAALAARIKEASRKLR---VTPFHFylaA 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2361 WAMFLSRLTGTRTVTFAETVSGRSPdiEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQnDKV-KVLDHQQIGLPRLV 2439
Cdd:cd19532    249 LQVLLARLLDVDDICIGIADANRTD--EDFMETIGFFLNLLPLRFRRDPSQTFADVLKETR-DKAyAALAHSRVPFDVLL 325


                   ....*.
gi 1827387616 2440 AQTGLP 2445
Cdd:cd19532    326 DELGVP 331

ACLS-CaiC

cd17637

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...

2720-3056

8.18e-22

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 99.65 E-value: 8.18e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGfASPSFDASVLEYLLATVNEGTL-----AYRPSEAVgg 2794
Cdd:cd17637      5 IIHTAAVAGRPRGAVLSHGNLIAANLQLIHAMGLTEADVYLN-MLPLFHIAGLNLALATFHAGGAnvvmeKFDPAEAL-- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2795 evleRFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAagGEAVPQPIvDRW---APATeLHNLYGPTETTIGIT 2865
Cdd:cd17637     82 ----ELIEEEKVTLMGSFPPILSNLldaaekSGVDLSSLRHVL--GLDAPETI-QRFeetTGAT-FWSLYGQTETSGLVT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2866 ISSAM-RPGDPvrlGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANpygtagqrMYRTGD 2944
Cdd:cd17637    154 LSPYReRPGSA---GRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNG--------WHHTGD 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2945 VVRWtpdtDTGGLtLEYTGRS--DDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVAT-ALAAYIVPVDGA-VEV 3020
Cdd:cd17637    223 LGRF----DEDGY-LWYAGRKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGeGIKAVCVLKPGAtLTA 297

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1827387616 3021 SELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd17637    298 DELIEFVGSRIARYKKPRYVVFVEALPKTADGSIDR 333

FUM14_C_NRPS-like

cd19545

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond ...

590-996

9.42e-22

Pssm-ID: 380467 [Multi-domain] Cd Length: 395 Bit Score: 100.45 E-value: 9.42e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  590 SGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVY-PSVGAAPVQdvlpVAVAREQLDWREADSVESLVRSttegf 668
Cdd:cd19545     19 PGAYVGQRVFELPPDIDLARLQAAWEQVVQANPILRTRIvQSDSGGLLQ----VVVKESPISWTESTSLDEYLEE----- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  669 DVSTQMPLRGRFHR------DGAGLHVALTMHHIAMDGQSIPVLARDLMSAYAARAEGRTgglpvldVQYADYalwqQSV 742
Cdd:cd19545     90 DRAAPMGLGGPLVRlalvedPDTERYFVWTIHHALYDGWSLPLILRQVLAAYQGEPVPQP-------PPFSRF----VKY 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  743 LGDADDETSVlgeqlSHWRRVLAGLpAVTDLPMDrPRPAVLGTAGATVTVEfdddladrvdVLARSNTMTGFMVTE---A 819
Cdd:cd19545    159 LRQLDDEAAA-----EFWRSYLAGL-DPAVFPPL-PSSRYQPRPDATLEHS----------ISLPSSASSGVTLATvlrA 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  820 AFAATVARLASTTDVVIGTPVAGRNDPA--LEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTTVLDA--FANDQVQfde 895
Cdd:cd19545    222 AWALVLSRYTGSDDVVFGVTLSGRNAPVpgIEQIVGPTIATVPLRVRIDPEQSVEDFLQTVQKDLLDMipFEHTGLQ--- 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  896 LIEALAPErsSSHQPLAQ--IAFTYTEPTVND---VAGLEASGIQAAPVDTgvvnakFDLTVAVRARSGGtpMAADFIYA 970
Cdd:cd19545    299 NIRRLGPD--ARAACNFQtlLVVQPALPSSTSeslELGIEEESEDLEDFSS------YGLTLECQLSGSG--LRVRARYD 368

                          410       420
                   ....*....|....*....|....*.
gi 1827387616  971 TDLFDESTVKRFAEVYRRVLQAIVDD 996
Cdd:cd19545    369 SSVISEEQVERLLDQFEHVLQQLASA 394

LC_FACS_like

cd17640

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...

1064-1464

1.11e-21

Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 101.67 E-value: 1.11e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDast 1143
Cdd:cd17640      8 YKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVALVVE--- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 rarlgesscewvdladleaeaESGDDItdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPE 1223
Cdd:cd17640     85 ---------------------NDSDDL--------------ATIIYTSGTTGNPKGVMLTHANLLHQIRSLSDIVPPQPG 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1224 DepdtRILHVASP--SFD--ASMFEMAWAIPAGHTLVIAPQADFAgdalatvlerdevtdmIITPSVLATV--------- 1290
Cdd:cd17640    130 D----RFLSILPIwhSYErsAEYFIFACGCSQAYTSIRTLKDDLK----------------RVKPHYIVSVprlweslys 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1291 ---------DPERAQYVRNLATGGE---------ACPPELVERWSERGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKP 1352
Cdd:cd17640    190 giqkqvsksSPIKQFLFLFFLSGGIfkfgisgggALPPHVDTFFEAIGIEVLNGYGLTETSPVVSARRLKCNVRGSVGRP 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1353 VDGFTVRVLDGRLHEV-PQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRA 1431
Cdd:cd17640    270 LPGTEIKIVDPEGNVVlPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSDGW-------FNTGDLGWLTCGGELVLTGRA 342

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1827387616 1432 -DHQVKINGQRVELGEIEAVLDAQPGVAQSVVVG 1464
Cdd:cd17640    343 kDTIVLSNGENVEPQPIEEALMRSPFIEQIMVVG 376

PRK06710

long-chain-fatty-acid--CoA ligase; Validated

1050-1532

1.45e-21

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 102.03 E-value: 1.45e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK06710    38 PEKKALHFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGIVVQTNPLYTERELEYQL 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATV---------GITDASTRARLGESSCEWV-----------------DLADLEAEAESGDDI-----TDTERNGS 1178
Cdd:PRK06710   118 HDSGAKVilcldlvfpRVTNVQSATKIEHVIVTRIadflpfpknllypfvqkKQSNLVVKVSESETIhlwnsVEKEVNTG 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1179 VRL-----TNLAYLIYTSGSTGRPKAVGVSHTGIVDfvNSLAKITTGTPEDEPDTRILHVAsPSFDASMFE--MAWAIPA 1251
Cdd:PRK06710   198 VEVpcdpeNDLALLQYTGGTTGFPKGVMLTHKNLVS--NTLMGVQWLYNCKEGEEVVLGVL-PFFHVYGMTavMNLSIMQ 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1252 GHTLVIAPQADFagDALATVLERDEVTDMIITPSVLATV--DPERAQY----VRNLATGGEACPPELVERWSE-RGRRIF 1324
Cdd:PRK06710   275 GYKMVLIPKFDM--KMVFEAIKKHKVTLFPGAPTIYIALlnSPLLKEYdissIRACISGSAPLPVEVQEKFETvTGGKLV 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1325 NCYGPTEAT-------VWATRSrmtagkPVTIGKPVDGFTVRVLDGRLHEV-PQGVVGELYLSTAGLARGYLGRPGQTAv 1396
Cdd:PRK06710   353 EGYGLTESSpvthsnfLWEKRV------PGSIGVPWPDTEAMIMSLETGEAlPPGEIGEIVVKGPQIMKGYWNKPEETA- 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1397 SFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhte 1476
Cdd:PRK06710   426 AVLQDGW-------LHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKVQEVVTIGVPDPYRGET--- 495

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 1477 VVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK06710   496 VKAFVVLKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIE 551

entE

PRK10946

(2,3-dihydroxybenzoyl)adenylate synthase;

97-468

1.97e-21

(2,3-dihydroxybenzoyl)adenylate synthase;

Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 101.61 E-value: 1.97e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   97 HVLDISSPGDADLDE------EEF-AGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFL--Y 167
Cdd:PRK10946   151 VVLLLNDDGEHSLDDainhpaEDFtATPSPADEVAFFQLSGGSTGTPKLIPRTHNDYYYSVRRSVEICGFTPQTRYLcaL 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  168 KAPITFDVSVreiflPIAIGA-----TLVIA-EPGrhgdPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVG--ELTS 239
Cdd:PRK10946   231 PAAHNYPMSS-----PGALGVflaggTVVLApDPS----ATLCFPLIEKHQVNVTALVPPAVSLWLQAIAEGGSraQLAS 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARdlmvRLP---GTRLQNQYGPAEAsiVVTIHRVTQDDRVIpIGTPTRRVS----ARVLDAALRE 312
Cdd:PRK10946   302 LKLLQVGGARLSETLAR----RIPaelGCQLQQVFGMAEG--LVNYTRLDDSDERI-FTTQGRPMSpddeVWVADADGNP 374

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  313 VPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEV 392
Cdd:PRK10946   375 LPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF-------YCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEI 447

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  393 EAALAAAPGVLHAA-AAVVDGPGGQQLVGYLAPADvDVDTVAATT---AELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK10946   448 ENLLLRHPAVIHAAlVSMEDELMGEKSCAFLVVKE-PLKAVQLRRflrEQGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526

PRK07638

acyl-CoA synthetase; Validated

5-465

3.83e-21

acyl-CoA synthetase; Validated

Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 100.24 E-value: 3.83e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGvGAEVAVGIQIDRSVE--QVVAihAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVtsdg 82
Cdd:PRK07638    31 DWFESVCKVANWLNEKE-SKNKTIAILLENRIEflQLFA--GAAMAGWTCVPLDIKWKQDELKERLAISNADMIVT---- 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   83 EAEARSRFDDiVDVHVLDISS-PGDADLDEEEFAGPTRPANAAFTL-FTSGSTGRPKAVVITHRGIANRLAADIEQYDLT 160
Cdd:PRK07638   104 ERYKLNDLPD-EEGRVIEIDEwKRMIEKYLPTYAPIENVQNAPFYMgFTSGSTGKPKAFLRAQQSWLHSFDCNVHDFHMK 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARD-----------VFLYKApitfdvsVREIFlpiaIGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAF--- 226
Cdd:PRK07638   183 REDsvliagtlvhsLFLYGA-------ISTLY----VGQTVHLM---RKFIPNQVLDKLETENISVMYTVPTMLESLyke 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  227 NEVLGagvgelTSLRLIQTGGEALTPPVARdLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVL 306
Cdd:PRK07638   249 NRVIE------NKMKIISSGAKWEAEAKEK-IKNIFPYAKLYEFYGASELSFVTALVDEESERRPNSVGRPFHNVQVRIC 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  307 DAALREVPIGVPGELYLGGVQLARGYAGRpdltaerfvADPFGEPGARLYRT-GDRARWNRDGEIEYLGRTDFQVKLRGQ 385
Cdd:PRK07638   322 NEAGEEVQKGEIGTVYVKSPQFFMGYIIG---------GVLARELNADGWMTvRDVGYEDEEGFIYIVGREKNMILFGGI 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  386 RLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLApADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVD 464
Cdd:PRK07638   393 NIFPEEIESVLHEHPAVDEIVViGVPDSYWGEKPVAIIK-GSATKQQLKSFCLQRLSSFKIPKEWHFVDEIPYTNSGKIA 471


                   .
gi 1827387616  465 R 465
Cdd:PRK07638   472 R 472

FACL_like_4

cd05944

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2716-3059

4.46e-21

Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 97.94 E-value: 4.46e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLgFASPSF--DASVLEYLLAT------VNEGTLAYR 2787
Cdd:cd05944      3 DVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDDVLL-CGLPLFhvNGSVVTLLTPLasgahvVLAGPAGYR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2788 PSEAVGGevLERFIAEHGATHTFLTPSVLSTM----DPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNL--YGPTETT 2861
Cdd:cd05944     82 NPGLFDN--FWKLVERYRITSLSTVPTVYAALlqvpVNADISSLRFAMSGAAPLPVELRARFEDATGLPVVegYGLTEAT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2862 IGITISSamrPGDPVRLGG-----PIGGVDLMVLD---ERLRPVPVGMPGELYVAGGALSRGYLDRSGltaerftaNPYG 2933
Cdd:cd05944    160 CLVAVNP---PDGPKRPGSvglrlPYARVRIKVLDgvgRLLRDCAPDEVGEICVAGPGVFGGYLYTEG--------NKNA 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2934 TAGQRMYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATAL-AAYIV 3012
Cdd:cd05944    229 FVADGWLNTGDLGRLDAD---GYLFI--TGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELpVAYVQ 303

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1827387616 3013 PVDGA-VEVSELKAFAGGRLPAYM-VPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05944    304 LKPGAvVEEEELLAWARDHVPERAaVPKHIEVLEELPVTAVGKVFKPAL 352

PRK05605

long-chain-fatty-acid--CoA ligase; Validated

97-466

5.55e-21

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 100.46 E-value: 5.55e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   97 HVLDISSPGDADLDEEEFAGPTRPAnaaFTLFTSGSTGRPKAVVITHRGI-ANRLAADIEQYDLTARDVFLYKA-PI--- 171
Cdd:PRK05605   198 TLVDAAIGGDGSDVSHPRPTPDDVA---LILYTSGTTGKPKGAQLTHRNLfANAAQGKAWVPGLGDGPERVLAAlPMfha 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  172 -------TFDVSvreiflpiaIGATLV-IAEPgrhgDPVHLADLIRRHGVTvihFVPAMLAAFNEVLGA----GVgELTS 239
Cdd:PRK05605   275 ygltlclTLAVS---------IGGELVlLPAP----DIDLILDAMKKHPPT---WLPGVPPLYEKIAEAaeerGV-DLSG 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 LRLIQTGGEALTPPVARdLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDA--ALREVPIGV 317
Cdd:PRK05605   338 VRNAFSGAMALPVSTVE-LWEKLTGGLLVEGYGLTETSPIIVGNPMSDDRRPGYVGVPFPDTEVRIVDPedPDETMPDGE 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA 397
Cdd:PRK05605   417 EGELLVRGPQVFKGYWNRPEETAKSFLDG--------WFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVLR 488

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616  398 AAPGVlhAAAAVVDGP---GGQQLVG--YLAP-ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRR 466
Cdd:PRK05605   489 EHPGV--EDAAVVGLPredGSEEVVAavVLEPgAALDPEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRRR 561

ACLS-CaiC

cd17637

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...

1187-1527

5.80e-21

Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 96.96 E-value: 5.80e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1187 LIYTSGSTGRPKAVGVSHTGIVdFVNSLAKITTGTPEDEPDTRIL---HVASPSFDASMFEmawaipAGHTLVIAPQadF 1263
Cdd:cd17637      5 IIHTAAVAGRPRGAVLSHGNLI-AANLQLIHAMGLTEADVYLNMLplfHIAGLNLALATFH------AGGANVVMEK--F 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1264 AGDALATVLERDEVTDMIITPSVLATVDPERAQYVRNLA-----TGGEAcpPELVERWSERGRRIFNC-YGPTEATVWAT 1337
Cdd:cd17637     76 DPAEALELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSslrhvLGLDA--PETIQRFEETTGATFWSlYGQTETSGLVT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1338 RSRMTAgKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADpfgepgarMYATGDLV 1417
Cdd:cd17637    154 LSPYRE-RPGSAGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNG--------WHHTGDLG 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1418 RVAKGGNLEFAGRADHQ--VKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTrggrKHTEVV-AYLVAKPGATIDSAAV 1494
Cdd:cd17637    225 RFDEDGYLWYAGRKPEKelIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDP----KWGEGIkAVCVLKPGATLTADEL 300

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1827387616 1495 LDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd17637    301 IEFVGSRIARYKKPRYVVFVEALPKTADGSIDR 333

ABCL

cd05958

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...

128-468

5.82e-21

Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 99.09 E-value: 5.82e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHR---GIANRLAADIeqYDLTARDVFLYKAPITFDVSVR-EIFLPIAIGATLVIAEpgrHGDPVH 203
Cdd:cd05958    104 FTSGTTGAPKATMHFHRdplASADRYAVNV--LRLREDDRFVGSPPLAFTFGLGgVLLFPFGVGASGVLLE---EATPDL 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  204 LADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVaRDLMVRLPGTRLQNQYGPAEAsIVVTIH 283
Cdd:cd05958    179 LLSAIARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKCVSAGEALPAAL-HRAWKEATGIPIIDGIGSTEM-FHIFIS 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGvqlARGYAGRPDLTAERFVADPFGEpgarlyrTGDRAR 363
Cdd:cd05958    257 ARPGDARPGATGKPVPGYEAKVVDDEGNPVPDGTIGRLAVRG---PTGCRYLADKRQRTYVQGGWNI-------TGDTYS 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  364 WNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGP---GGQQLVGYL------APADVDVDTVAA 434
Cdd:cd05958    327 RDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAV--AECAVVGHPdesRGVVVKAFVvlrpgvIPGPVLARELQD 404

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1827387616  435 TTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05958    405 HAKAHIAPYKYPRAIEFVTELPRTATGKLQRFAL 438

AFD_YhfT-like

cd17633

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...

1183-1527

6.03e-21

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain

Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 96.71 E-value: 6.03e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASP-SFDASMFEMAWAIPAGHTLVIapQA 1261
Cdd:cd17633      1 NPFYIGFTSGTTGLPKAYYRSERSWIESFVCNEDLFNISGED-----AILAPGPlSHSLFLYGAISALYLGGTFIG--QR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1262 DFAGDALATVLERDEVTDMIITPSVLA----TVDPERAqyVRNLATGGEACPPELVERWsergRRIFN------CYGPTE 1331
Cdd:cd17633     74 KFNPKSWIRKINQYNATVIYLVPTMLQalarTLEPESK--IKSIFSSGQKLFESTKKKL----KNIFPkanlieFYGTSE 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1332 ATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGrlhevPQGVVGELYLSTAGLARGYLGRPGQTAVSFvadpfgepgarmY 1411
Cdd:cd17633    148 LSFITYNFNQESRPPNSVGRPFPNVEIEIRNA-----DGGEIGKIFVKSEMVFSGYVRGGFSNPDGW------------M 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1412 ATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEVVAYLVAkpGATIDS 1491
Cdd:cd17633    211 SVGDIGYVDEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFG----EIAVALYS--GDKLTY 284

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1827387616 1492 AAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd17633    285 KQLKRFLKQKLSRYEIPKKIIFVDSLPYTSSGKIAR 320

FAAL

cd05931

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...

2575-3020

6.74e-21

Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 100.01 E-value: 6.74e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVV-----DGAGARLTYRELDEASDRLARWLIGRGvGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPD 2649
Cdd:cd05931      3 AAARPDRPAYTflddeGGREETLTYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLPPP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2650 YP---AERVASMIEDSGAVLGLSVLASGDLPgQEFEWMRLDDDSVAAEIAAVPAGPITDAERLGEVTAANLAYVIYTSGS 2726
Cdd:cd05931     82 TPgrhAERLAAILADAGPRVVLTTAAALAAV-RAFAASRPAAGTPRLLVVDLLPDTSAADWPPPSPDPDDIAYLQYTSGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2727 TGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAY---------RPSeavggevl 2797
Cdd:cd05931    161 TGTPKGVVVTHRNLLANVRQIRRAYGLDPGDVVVSWLPLYHDMGLIGGLLTPLYSGGPSVlmspaaflrRPL-------- 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2798 eRF---IAEHGATHTF------------LTPSVLSTMDptaVPSLRVIAAGGEAVPQPIVDRWAPATELHNL-------- 2854
Cdd:cd05931    233 -RWlrlISRYRATISAapnfaydlcvrrVRDEDLEGLD---LSSWRVALNGAEPVRPATLRRFAEAFAPFGFrpeafrps 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 YGPTETTIGITIS--------------------SAMRPGDP-----VRLGGPIGGVDLMVLD-ERLRPVPVGMPGELYVA 2908
Cdd:cd05931    309 YGLAEATLFVSGGppgtgpvvlrvdrdalagraVAVAADDPaarelVSCGRPLPDQEVRIVDpETGRELPDGEVGEIWVR 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2909 GGALSRGYLDRSGLTAERFTANPyGTAGQRMYRTGD---VVRwtpdtdtGGLTLeyTGRSDDQVKLRGLRIELGEIEAVL 2985
Cdd:cd05931    389 GPSVASGYWGRPEATAETFGALA-ATDEGGWLRTGDlgfLHD-------GELYI--TGRLKDLIIVRGRNHYPQDIEATA 458

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1827387616 2986 AEHDAVesavvlGVGGSVatalAAYIVPVDGAVEV 3020
Cdd:cd05931    459 EEAHPA------LRPGCV----AAFSVPDDGEERL 483

FACL_like_1

cd05910

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1061-1505

6.86e-21

Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 99.07 E-value: 6.86e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAIARALLARGVSPeDVVAVGMER-SIGSVLATWGVIKSGAAYVPVDPAYpadriaymledsgatvgit 1139
Cdd:cd05910      2 RLSFRELDERSDRIAQGLTAYGIRR-GMRAVLMVPpGPDFFALTFALFKAGAVPVLIDPGM------------------- 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 dasTRARLGEssCewvdLADLEAEAESGDDITDTErngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITT 1219
Cdd:cd05910     62 ---GRKNLKQ--C----LQEAEPDAFIGIPKADEP----------AAILFTSGSTGTPKGVVYRHGTFAAQIDALRQLYG 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1220 GTPEDepdtrILHVASPSFdaSMFEMAWAIPAghtlvIAPQADFAGDA------LATVLERDEVTDMIITPSVLATVDPE 1293
Cdd:cd05910    123 IRPGE-----VDLATFPLF--ALFGPALGLTS-----VIPDMDPTRPAradpqkLVGAIRQYGVSIVFGSPALLERVARY 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1294 RAQY------VRNLATGGEACPPELVERWSE---RGRRIFNCYGPTEA---------TVWATRSRMTA-GKPVTIGKPVD 1354
Cdd:cd05910    191 CAQHgitlpsLRRVLSAGAPVPIALAARLRKmlsDEAEILTPYGATEAlpvssigsrELLATTTAATSgGAGTCVGRPIP 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1355 GFTVRVLD---------GRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMyatGDLVRVAKGGNL 1425
Cdd:cd05910    271 GVRVRIIEiddepiaewDDTLELPRGEIGEITVTGPTVTPTYVNRPVATALAKIDDNSEGFWHRM---GDLGYLDDEGRL 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1426 EFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVesTRGGRKHTEVVayLVAKPGATIDSAAVLDEAAQHLAAH 1505
Cdd:cd05910    348 WFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV--GKPGCQLPVLC--VEPLPGTITPRARLEQELRALAKDY 423

FACL_like_5

cd05924

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2719-3057

9.28e-21

Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 97.07 E-value: 9.28e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2719 YVIYTSGSTGRPKGVAVTHS-------GLANFARQE------SDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLA 2785
Cdd:cd05924      7 YILYTGGTTGMPKGVMWRQEdifrmlmGGADFGTGEftpsedAHKAAAAAAGTVMFPAPPLMHGTGSWTAFGGLLGGQTV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2786 YRPSEAVGGEVLERFIAEHGATHTFLT------PSV--LSTMDPTAVPSLRVIAAGGEAVPQPIVDRW---APATELHNL 2854
Cdd:cd05924     87 VLPDDRFDPEEVWRTIEKHKVTSMTIVgdamarPLIdaLRDAGPYDLSSLFAISSGGALLSPEVKQGLlelVPNITLVDA 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 YGPTETTIGITISSAMRPGD--PVRLGGPiggvDLMVLDERLRPVPVGMPGELYVA-GGALSRGYLDRSGLTAERF-TAN 2930
Cdd:cd05924    167 FGSSETGFTGSGHSAGSGPEtgPFTRANP----DTVVLDDDGRVVPPGSGGVGWIArRGHIPLGYYGDEAKTAETFpEVD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2931 pygtaGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GGSVAT 3005
Cdd:cd05924    243 -----GVRYAVPGDRATVEADG-----TVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRpderwGQEVVA 312

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 3006 alaayIVPVDGAVEVS--ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKR 3057
Cdd:cd05924    313 -----VVQLREGAGVDleELREHCRTRIARYKLPKQVVFVDEIERSPAGKADYR 361

AFD_YhfT-like

cd17633

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...

128-465

1.70e-20

Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 95.55 E-value: 1.70e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepgRHGDPVHLADL 207
Cdd:cd17633      7 FTSGTTGLPKAYYRSERSWIESFVCNEDLFNISGEDAILAPGPLSHSLFLYGAISALYLGGTFIGQ---RKFNPKSWIRK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  208 IRRHGVTVIHFVPAMLAAFNEVLGAgvgeLTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVvTIHRVTQ 287
Cdd:cd17633     84 INQYNATVIYLVPTMLQALARTLEP----ESKIKSIFSSGQKLFESTKKKLKNIFPKANLIEFYGTSELSFI-TYNFNQE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  288 DDRVIPIGTPTRRVSARVLDAALREVpigvpGELYLGGVQLARGYAGRPDLTAERFvadpfgepgarlYRTGDRARWNRD 367
Cdd:cd17633    159 SRPPNSVGRPFPNVEIEIRNADGGEI-----GKIFVKSEMVFSGYVRGGFSNPDGW------------MSVGDIGYVDEE 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  368 GEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADVDVDTVAATTAELLPEYMRP 446
Cdd:cd17633    222 GYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVvGIPDARFGEIAVALYSGDKLTYKQLKRFLKQKLSRYEIP 301

                          330
                   ....*....|....*....
gi 1827387616  447 SAWVRLDAMPLSRSGKVDR 465
Cdd:cd17633    302 KKIIFVDSLPYTSSGKIAR 320

PRK06164

acyl-CoA synthetase; Validated

1-461

2.10e-20

acyl-CoA synthetase; Validated

Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 98.28 E-value: 2.10e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQ---------LPVDRARYMVRTA 71
Cdd:PRK06164    36 LSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVNTRyrshevahiLGRGRARWLVVWP 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   72 GVR---LVVVTSDGEAEARSRFDDIVDVHVLDISSPGDADLDEEE-FAGPTRPANAA--------------FTlfTSGST 133
Cdd:PRK06164   116 GFKgidFAAILAAVPPDALPPLRAIAVVDDAADATPAPAPGARVQlFALPDPAPPAAageraadpdagallFT--TSGTT 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  134 GRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGrhgDPVHLADLIRRHGV 213
Cdd:PRK06164   194 SGPKLVLHRQATLLRHARAIARAYGYDPGAVLLAALPFCGVFGFSTLLGALAGGAPLVCEPVF---DAARTARALRRHRV 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  214 TVIHFVPAMLAAFNEVLGAGvGELTSLRLIqtgGEALTPPVARDLM--VRLPGTRLQNQYGPAEASIVVTIHRVTQD--D 289
Cdd:PRK06164   271 THTFGNDEMLRRILDTAGER-ADFPSARLF---GFASFAPALGELAalARARGVPLTGLYGSSEVQALVALQPATDPvsV 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  290 RVIPIGTPTR---RVSAR-VLDAALreVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWN 365
Cdd:PRK06164   347 RIEGGGRPASpeaRVRARdPQDGAL--LPDGESGEIEIRAPSLMRGYLDNPDATARALTDDGY-------FRTGDLGYTR 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  366 RDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGYLAPAD---VDVDTVAATTAELLPE 442
Cdd:PRK06164   418 GDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGATRDGKTVPVAFVIPTDgasPDEAGLMAACREALAG 497

                          490
                   ....*....|....*....
gi 1827387616  443 YMRPSAWVRLDAMPLSRSG 461
Cdd:PRK06164   498 FKVPARVQVVEAFPVTESA 516

PtmA

cd17636

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...

1187-1526

2.24e-20

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 95.06 E-value: 2.24e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1187 LIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITtgtpEDEPDTRILhVASPSFD-ASMFEMAWAIPAGHTLVIAPQADFAG 1265
Cdd:cd17636      5 AIYTAAFSGRPNGALLSHQALLAQALVLAVLQ----AIDEGTVFL-NSGPLFHiGTLMFTLATFHAGGTNVFVRRVDAEE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1266 daLATVLERDEVTDMIITPSVLATVDPERAQYVRNLAT--------GGEACPPELVERWSERGRRifncYGPTEATVWAT 1337
Cdd:cd17636     80 --VLELIEAERCTHAFLLPPTIDQIVELNADGLYDLSSlrsspaapEWNDMATVDTSPWGRKPGG----YGQTEVMGLAT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1338 RSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVadpfgepgARMYATGDLV 1417
Cdd:cd17636    154 FAALGGGAIGGAGRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTR--------GGWHHTNDLG 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1418 RVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDE 1497
Cdd:cd17636    226 RREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQ---SVKAIVVLKPGASVTEAELIEH 302

                          330       340
                   ....*....|....*....|....*....
gi 1827387616 1498 AAQHLAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:cd17636    303 CRARIASYKKPKSVEFADALPRTAGGADD 331

PRK12406

long-chain-fatty-acid--CoA ligase; Provisional

2591-3062

2.74e-20

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 97.46 E-value: 2.74e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2591 RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGA-VL--- 2666
Cdd:PRK12406    11 RRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGArVLiah 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2667 -------------GLSVLaSGDLPGQEFEWMRLDDDSvaaeiAAVPAGPITDAERLGE------VTAANLAYVIYTSGST 2727
Cdd:PRK12406    91 adllhglasalpaGVTVL-SVPTPPEIAAAYRISPAL-----LTPPAGAIDWEGWLAQqepydgPPVPQPQSMIYTSGTT 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2728 GRPKGV---AVTHSGLANFARQEsdRLNAGDNP-VVLGFASPSFDASVLEYllatvneGTLAYRPSEAVggeVLE-RF-- 2800
Cdd:PRK12406   165 GHPKGVrraAPTPEQAAAAEQMR--ALIYGLKPgIRALLTGPLYHSAPNAY-------GLRAGRLGGVL---VLQpRFdp 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2801 ------IAEHGATHTFLTPSVLST-MD-PTAV------PSLRVIAAGGEAVPQPI----VDRWAPAteLHNLYGPTETTI 2862
Cdd:PRK12406   233 eellqlIERHRITHMHMVPTMFIRlLKlPEEVrakydvSSLRHVIHAAAPCPADVkramIEWWGPV--IYEYYGSTESGA 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2863 GITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYV--AGGAL--------SRGYLDRSGLTaerftanpy 2932
Cdd:PRK12406   311 VTFATSEDALSHPGTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSriAGNPDftyhnkpeKRAEIDRGGFI--------- 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2933 gTAGQRMYRTGDVVRWTPDtdtggltleytgRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS-VATALAAYI 3011
Cdd:PRK12406   382 -TSGDVGYLDADGYLFLCD------------RKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAeFGEALMAVV 448

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 3012 VPVDGA-VEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEP 3062
Cdd:PRK12406   449 EPQPGAtLDEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDP 500

PRK03640

o-succinylbenzoate--CoA ligase;

1-468

3.15e-20

o-succinylbenzoate--CoA ligase;

Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 97.34 E-value: 3.15e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK03640    28 VTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREELLWQLDDAEVKCLITDD 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAE----ARSRFDDIVDVHVLDISSPGDADLDEeefagptrpanAAFTLFTSGSTGRPKAVVITHrgiANRLAADI-- 154
Cdd:PRK03640   108 DFEAKlipgISVKFAELMNGPKEEAEIQEEFDLDE-----------VATIMYTSGTTGKPKGVIQTY---GNHWWSAVgs 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  155 -EQYDLTARDVFLYKAPItFDVSVREIFLPIAI-GATLVIAEpgrHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGA 232
Cdd:PRK03640   174 aLNLGLTEDDCWLAAVPI-FHISGLSILMRSVIyGMRVVLVE---KFDAEKINKLLQTGGVTIISVVSTMLQRLLERLGE 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  233 GvGELTSLRLIQTGGEaltpPVARDLM--VRLPGTRLQNQYGPAE-ASIVVTIhrvTQDDRVIPIGT---PTRRVSARVL 306
Cdd:PRK03640   250 G-TYPSSFRCMLLGGG----PAPKPLLeqCKEKGIPVYQSYGMTEtASQIVTL---SPEDALTKLGSagkPLFPCELKIE 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  307 DaALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEYLGRTDFQVKLRGQR 386
Cdd:PRK03640   322 K-DGVVVPPFEEGEIVVKGPNVTKGYLNREDATRETFQDGWF--------KTGDIGYLDEEGFLYVLDRRSDLIISGGEN 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  387 LELGEVEAALAAAPGVlhAAAAVV---DGPGGQQLVGYL-APADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGK 462
Cdd:PRK03640   393 IYPAEIEEVLLSHPGV--AEAGVVgvpDDKWGQVPVAFVvKSGEVTEEELRHFCEEKLAKYKVPKRFYFVEELPRNASGK 470


                   ....*.
gi 1827387616  463 VDRRLL 468
Cdd:PRK03640   471 LLRHEL 476

PRK08974

long-chain-fatty-acid--CoA ligase FadD;

2566-3059

4.09e-20

long-chain-fatty-acid--CoA ligase FadD;

Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 97.43 E-value: 4.09e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVVDgAGARLTYRELDEASDRLARWLiGRGVGPERA--VALAIGRSAQLLTAIWAVAKTGGAY 2643
Cdd:PRK08974    24 SLVDMFEQAVARYADQPAFIN-MGEVMTFRKLEERSRAFAAYL-QNGLGLKKGdrVALMMPNLLQYPIALFGILRAGMIV 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2644 VPIDPDYPAERVASMIEDSGA--VLGLSVLASG------DLPGQEFEWMRLDD----------DSVAAEIAA-VPAGPIT 2704
Cdd:PRK08974   102 VNVNPLYTPRELEHQLNDSGAkaIVIVSNFAHTlekvvfKTPVKHVILTRMGDqlstakgtlvNFVVKYIKRlVPKYHLP 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2705 DA----------ERLG----EVTAANLAYVIYTSGSTGRPKGVAVTHSG-LANFARQE---SDRLNAGDNPVVLgfASPs 2766
Cdd:PRK08974   182 DAisfrsalhkgRRMQyvkpELVPEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQAKaayGPLLHPGKELVVT--ALP- 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2767 fdasvLEYLLA-TVN---------EGTLAYRPSEaVGGEVLE----RFIAEHGATHTFltPSVLSTMDPTAV--PSLRVI 2830
Cdd:PRK08974   259 -----LYHIFAlTVNcllfielggQNLLITNPRD-IPGFVKElkkyPFTAITGVNTLF--NALLNNEEFQELdfSSLKLS 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2831 AAGGEAVPQPIVDRWAPATELHNL--YGPTETTIGITISsamrPGDPVRLGGPIG----GVDLMVLDERLRPVPVGMPGE 2904
Cdd:PRK08974   331 VGGGMAVQQAVAERWVKLTGQYLLegYGLTECSPLVSVN----PYDLDYYSGSIGlpvpSTEIKLVDDDGNEVPPGEPGE 406

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2905 LYVAGGALSRGYLDRSGLTAERFTanpygtagQRMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAV 2984
Cdd:PRK08974   407 LWVKGPQVMLGYWQRPEATDEVIK--------DGWLATGDIAV----MDEEGF-LRIVDRKKDMILVSGFNVYPNEIEDV 473

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2985 LAEHDAVESAVVLGVGGSVA-TALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK08974   474 VMLHPKVLEVAAVGVPSEVSgEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRREL 549

A_NRPS_TubE_like

cd05906

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...

1058-1530

4.55e-20

Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 97.35 E-value: 4.55e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1058 DGTE--MDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSG--AAYVPVDPAY--PADRIAYmLED 1131
Cdd:cd05906     34 DGSEefQSYQDLLEDARRLAAGLRQLGLRPGDSVILQFDDNEDFIPAFWACVLAGfvPAPLTVPPTYdePNARLRK-LRH 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1132 SGATVG----ITDASTRARLGESSCEWVDLADLEAEAESGDDiTDTERNG-SVRLTNLAYLIYTSGSTGRPKAVGVSHTG 1206
Cdd:cd05906    113 IWQLLGspvvLTDAELVAEFAGLETLSGLPGIRVLSIEELLD-TAADHDLpQSRPDDLALLMLTSGSTGFPKAVPLTHRN 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1207 IVDfvNSLAKITTGtpEDEPDTRIL------HVASpsfdASMFEMAwAIPAGHTLVIAPQADFAGDALATV--LERDEVT 1278
Cdd:cd05906    192 ILA--RSAGKIQHN--GLTPQDVFLnwvpldHVGG----LVELHLR-AVYLGCQQVHVPTEEILADPLRWLdlIDRYRVT 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1279 dmiIT--P----SVLATVDPERAQY------VRNLATGGEACPPE----LVERWSERGRRIF----------NCYGPTEA 1332
Cdd:cd05906    263 ---ITwaPnfafALLNDLLEEIEDGtwdlssLRYLVNAGEAVVAKtirrLLRLLEPYGLPPDairpafgmteTCSGVIYS 339

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1333 TVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYA 1412
Cdd:cd05906    340 RSFPTYDHSQALEFVSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEAFTEDGW-------FR 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1413 TGDLVRVaKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVeSTRGGRKHTEVVAyLVAKPGATIDSA 1492
Cdd:cd05906    413 TGDLGFL-DNGNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPSFTAAF-AVRDPGAETEELA-IFFVPEYDLQDA 489

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 1493 --AVLDEAAQHLAAHMVPSQAIVI----DEIPLTPAGKLDRAAL 1530
Cdd:cd05906    490 lsETLRAIRSVVSREVGVSPAYLIplpkEEIPKTSLGKIQRSKL 533

PtmA

cd17636

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...

2720-3055

5.68e-20

Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 93.91 E-value: 5.68e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGfASPSFDASVLEYLLAT-VNEGTLAYRPseAVGGEVLE 2798
Cdd:cd17636      5 AIYTAAFSGRPNGALLSHQALLAQALVLAVLQAIDEGTVFLN-SGPLFHIGTLMFTLATfHAGGTNVFVR--RVDAEEVL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2799 RFIAEHGATHTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHnLYGPTETTiGITISSAMRP 2872
Cdd:cd17636     82 ELIEAERCTHAFLLPPTIDQIvelnadGLYDLSSLRSSPAAPEWNDMATVDTSPWGRKPG-GYGQTEVM-GLATFAALGG 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2873 GDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTAnpygtagqRMYRTGDVVRWTPDT 2952
Cdd:cd17636    160 GAIGGAGRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTRG--------GWHHTNDLGRREPDG 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2953 dtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSV-ATALAAYIVPVDGA-VEVSELKAFAGGR 3030
Cdd:cd17636    232 -----SLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRwAQSVKAIVVLKPGAsVTEAELIEHCRAR 306

                          330       340
                   ....*....|....*....|....*
gi 1827387616 3031 LPAYMVPSSFTVIDELPLTPVGKLD 3055
Cdd:cd17636    307 IASYKKPKSVEFADALPRTAGGADD 331

FACL_like_1

cd05910

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

107-439

7.16e-20

Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 95.61 E-value: 7.16e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  107 ADLDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITfdvsvrEIFLPiAI 186
Cdd:cd05910     71 QEAEPDAFIGIPKADEPAAILFTSGSTGTPKGVVYRHGTFAAQIDALRQLYGIRPGEVDLATFPLF------ALFGP-AL 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  187 GATLVIAE-----PGRhGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVR 261
Cdd:cd05910    144 GLTSVIPDmdptrPAR-ADPQKLVGAIRQYGVSIVFGSPALLERVARYCAQHGITLPSLRRVLSAGAPVPIALAARLRKM 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  262 L-PGTRLQNQYGPAEASIVVTI---------HRVTQDDRVIPIGTPTRRVSARVLDA---------ALREVPIGVPGELY 322
Cdd:cd05910    223 LsDEAEILTPYGATEALPVSSIgsrellattTAATSGGAGTCVGRPIPGVRVRIIEIddepiaewdDTLELPRGEIGEIT 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  323 LGGVQLARGYAGRPDLTAERFVADPfgePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGV 402
Cdd:cd05910    303 VTGPTVTPTYVNRPVATALAKIDDN---SEGFWHRMGDLGYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGV 379

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1827387616  403 LHAAAAVVDGPGGQQLVGYLAPADVDVDTVAATTAEL 439
Cdd:cd05910    380 RRSALVGVGKPGCQLPVLCVEPLPGTITPRARLEQEL 416

PRK07824

o-succinylbenzoate--CoA ligase;

2703-3059

8.81e-20

o-succinylbenzoate--CoA ligase;

Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 93.96 E-value: 8.81e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2703 ITDAERLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLnAGDNPVVLgfASPSFDASVLEYLLATVNEG 2782
Cdd:PRK07824    23 LRDALRVGEPIDDDVALVVATSGTTGTPKGAMLTAAALTASADATHDRL-GGPGQWLL--ALPAHHIAGLQVLVRSVIAG 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2783 T--LAYRPSEAVGGEVLERFIAEHGA--THTFLTPSVLSTM--DPTAVPSLRVIAA---GGEAVPQPIVDRWAPA-TELH 2852
Cdd:PRK07824   100 SepVELDVSAGFDPTALPRAVAELGGgrRYTSLVPMQLAKAldDPAATAALAELDAvlvGGGPAPAPVLDAAAAAgINVV 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2853 NLYGPTETTigitissamrpGDPVRLGGPIGGVDLMVLDERLrpvpvgmpgelYVAGGALSRGYldRSGLTAERFtANPy 2932
Cdd:PRK07824   180 RTYGMSETS-----------GGCVYDGVPLDGVRVRVEDGRI-----------ALGGPTLAKGY--RNPVDPDPF-AEP- 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2933 gtagqrmyrtgdvvRWTPDTDTGGLT---LEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-----GGSVA 3004
Cdd:PRK07824   234 --------------GWFRTDDLGALDdgvLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVFGLpddrlGQRVV 299

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 3005 talAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK07824   300 ---AAVVGDGGPAPTLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRAL 351

MACS_AAE_MA_like

cd05970

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...

2573-3058

9.38e-20

Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 96.03 E-value: 9.38e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2573 AAARRAPDHVAVV--DGAGAR--LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVP--- 2645
Cdd:cd05970     25 AMAKEYPDKLALVwcDDAGEEriFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAIAIPath 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2646 ---------------------IDPDYPAERVASMIEDSGAVLGLsVLASGDLPGQEFEWMRLDDDsvAAEIAAVPAGPit 2704
Cdd:cd05970    105 qltakdivyriesadikmivaIAEDNIPEEIEKAAPECPSKPKL-VWVGDPVPEGWIDFRKLIKN--ASPDFERPTAN-- 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2705 dAERLGEvtaaNLAYVIYTSGSTGRPKGVA------VTHSGLANFARqesdrlNAGDNPVVLGFASPSFDASVLEYLLAT 2778
Cdd:cd05970    180 -SYPCGE----DILLVYFSSGTTGMPKMVEhdftypLGHIVTAKYWQ------NVREGGLHLTVADTGWGKAVWGKIYGQ 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2779 VNEGT--LAYRPSEAVGGEVLERfIAEHGAT--------HTFLTPSVLSTMDptaVPSLRVIAAGGEAVPQPIVDRWAPA 2848
Cdd:cd05970    249 WIAGAavFVYDYDKFDPKALLEK-LSKYGVTtfcapptiYRFLIREDLSRYD---LSSLRYCTTAGEALNPEVFNTFKEK 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2849 T--ELHNLYGPTETTIGITISSAMRPgDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYV--AGG---ALSRGYLDRSG 2921
Cdd:cd05970    325 TgiKLMEGFGQTETTLTIATFPWMEP-KPGSMGKPAPGYEIDLIDREGRSCEAGEEGEIVIrtSKGkpvGLFGGYYKDAE 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2922 LTAERFTANpygtagqrMYRTGDVVrWTpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGG 3001
Cdd:cd05970    404 KTAEVWHDG--------YYHTGDAA-WM---DEDGY-LWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLECAVTGVPD 470

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 3002 SV-ATALAAYIVPVDG--AVEV--SELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLdKRA 3058
Cdd:cd05970    471 PIrGQVVKATIVLAKGyePSEElkKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKI-RRV 531

PRK08043

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

117-474

9.45e-20

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 97.09 E-value: 9.45e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  117 PTRPANAAFTLFTSGSTGRPKAVVITHrgiaNRLAADIEQY----DLTARDVFLYKAPI--TFDVSVrEIFLPIAIGATL 190
Cdd:PRK08043   361 KQQPEDAALILFTSGSEGHPKGVVHSH----KSLLANVEQIktiaDFTPNDRFMSALPLfhSFGLTV-GLFTPLLTGAEV 435

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  191 VIaepgrHGDPVH---LADLIRRHGVTVIHFVPAMLAAFNEVlgAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRL 267
Cdd:PRK08043   436 FL-----YPSPLHyriVPELVYDRNCTVLFGTSTFLGNYARF--ANPYDFARLRYVVAGAEKLQESTKQLWQDKF-GLRI 507

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  268 QNQYGPAEASIVVTIHrvtqddrvIPIGTPTRRVsARVL---DAALREVP-IGVPGELYLGGVQLARGY--AGRPDLTAE 341
Cdd:PRK08043   508 LEGYGVTECAPVVSIN--------VPMAAKPGTV-GRILpgmDARLLSVPgIEQGGRLQLKGPNIMNGYlrVEKPGVLEV 578

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  342 RFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEA-ALAAAPGVLHAAAAVVDGPGGQQLVG 420
Cdd:PRK08043   579 PTAENARGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQlALGVSPDKQHATAIKSDASKGEALVL 658

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  421 YLAPADVDVDTVAATTAEL-LPEYMRPSAWVRLDAMPLSRSGKVD----RRLLPEPEIA 474
Cdd:PRK08043   659 FTTDSELTREKLQQYAREHgVPELAVPRDIRYLKQLPLLGSGKPDfvtlKSMVDEPEQH 717

AACS_like

cd05968

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...

1019-1527

1.14e-19

Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 96.41 E-value: 1.14e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1019 VSARTPGAMVGRGGEVeagTLIDVLAQRDL--DPDHPALICDGTE-----MDYDEFETRTNAIARALLARGVSPEDVVAV 1091
Cdd:cd05968     45 LSGGKPWAAWFVGGRM---NIVEQLLDKWLadTRTRPALRWEGEDgtsrtLTYGELLYEVKRLANGLRALGVGKGDRVGI 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1092 GMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT-DASTR----------ARLGESSCEWVDL--- 1157
Cdd:cd05968    122 YLPMIPEIVPAFLAVARIGGIVVPIFSGFGKEAAATRLQDAEAKALITaDGFTRrgrevnlkeeADKACAQCPTVEKvvv 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1158 ---ADLEAEAESGDDITDTERNGS--VRLTNLA-----YLIYTSGSTGRPKAVGVSHTGIvdfvNSLAKITTGTPED-EP 1226
Cdd:cd05968    202 vrhLGNDFTPAKGRDLSYDEEKETagDGAERTEsedplMIIYTSGTTGKPKGTVHVHAGF----PLKAAQDMYFQFDlKP 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1227 DTRILHVASPSFDASMFEMAWAIPAGHTLVI---APQADFAgDALATVLERDEVTDMIITPSVLATVDPERAQYV----- 1298
Cdd:cd05968    278 GDLLTWFTDLGWMMGPWLIFGGLILGATMVLydgAPDHPKA-DRLWRMVEDHEITHLGLSPTLIRALKPRGDAPVnahdl 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1299 ---RNLATGGEACPPE----LVERWSERGRRIFNCYGPTEatvwatrsrMTAG----------KPVTIGKPVDGFTVRVL 1361
Cdd:cd05968    357 sslRVLGSTGEPWNPEpwnwLFETVGKGRNPIINYSGGTE---------ISGGilgnvlikpiKPSSFNGPVPGMKADVL 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1362 DGRLHEVPqGVVGELYLSTA--GLARGYLGRPGQtavsfVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKING 1439
Cdd:cd05968    428 DESGKPAR-PEVGELVLLAPwpGMTRGFWRDEDR-----YLETYWSRFDNVWVHGDFAYYDEEGYFYILGRSDDTINVAG 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1440 QRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhTEVVAYLVAKPGATiDSAAVLDEAAQHLAAHM----VPSQAIVID 1515
Cdd:cd05968    502 KRVGPAEIESVLNAHPAVLESAAIGVPHPVKG---EAIVCFVVLKPGVT-PTEALAEELMERVADELgkplSPERILFVK 577

                          570
                   ....*....|..
gi 1827387616 1516 EIPLTPAGKLDR 1527
Cdd:cd05968    578 DLPKTRNAKVMR 589

PLN02246

4-coumarate--CoA ligase

42-468

1.19e-19

4-coumarate--CoA ligase

Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 95.82 E-value: 1.19e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   42 IHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVrlVVVTSDGEAEarsrfddiVDVHVLDISSPGDADLDEEEFAgptrPA 121
Cdd:PLN02246   114 IAKQAKASGAKLIITQSCYVDKLKGLAEDDGV--TVVTIDDPPE--------GCLHFSELTQADENELPEVEIS----PD 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  122 NAAFTLFTSGSTGRPKAVVITHRG----IANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFL-PIAIGATLVIAepg 196
Cdd:PLN02246   180 DVVALPYSSGTTGLPKGVMLTHKGlvtsVAQQVDGENPNLYFHSDDVILCVLPMFHIYSLNSVLLcGLRVGAAILIM--- 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  197 RHGDPVHLADLIRRHGVTVIHFVPAMLAAF--NEVLGAgvGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPA 274
Cdd:PLN02246   257 PKFEIGALLELIQRHKVTIAPFVPPIVLAIakSPVVEK--YDLSSIRMVLSGAAPLGKELEDAFRAKLPNAVLGQGYGMT 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  275 EASIVVTIHRVTQDDrVIPI-----GTPTRRVSARVLDAALRE-VPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPF 348
Cdd:PLN02246   335 EAGPVLAMCLAFAKE-PFPVksgscGTVVRNAELKIVDPETGAsLPRNQPGEICIRGPQIMKGYLNDPEATANTIDKDGW 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  349 gepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVV---DGPGGQQLVGYLAPA 425
Cdd:PLN02246   414 -------LHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSI--ADAAVVpmkDEVAGEVPVAFVVRS 484

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616  426 ---DVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PLN02246   485 ngsEITEDEIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDL 530

PRK13383

acyl-CoA synthetase; Provisional

1-469

1.63e-19

acyl-CoA synthetase; Provisional

Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 95.45 E-value: 1.63e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTS 80
Cdd:PRK13383    61 LSYRELQRATESLARRLTRDGVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFRSDALAAALRAHHIS-TVVAD 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDivDVHVLDISSPGdadlDEEEFAGPTRPANAAFTLFTSGSTGRPKAV-----VITHRGIANRLaadIE 155
Cdd:PRK13383   140 NEFAERIAGADD--AVAVIDPATAG----AEESGGRPAVAAPGRIVLLTSGTTGKPKGVprapqLRSAVGVWVTI---LD 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  156 QYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepgRHGDP---VHLADLIRRHGVTVihfVPAMLAAFNEVLGA 232
Cdd:PRK13383   211 RTRLRTGSRISVAMPMFHGLGLGMLMLTIALGGTVLTH---RHFDAeaaLAQASLHRADAFTA---VPVVLARILELPPR 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  233 --GVGELTSLRLIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAAL 310
Cdd:PRK13383   285 vrARNPLPQLRVVMSSGDRLDPTLGQRFM-DTYGDILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNN 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  311 REVPIGVPGELYLGGVQLARGYAGrpdlTAERFVADPfgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELG 390
Cdd:PRK13383   364 RPVGPRVTGRIFVGGELAGTRYTD----GGGKAVVDG-------MTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPR 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  391 EVEAALAAAPGVL-HAAAAVVDGPGGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRR 466
Cdd:PRK13383   433 AVENALAAHPAVAdNAVIGVPDERFGHRLAAFVVLhpgSGVDAAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRK 512


                   ...
gi 1827387616  467 LLP 469
Cdd:PRK13383   513 ELP 515

PRK08751

long-chain fatty acid--CoA ligase;

2566-3059

1.71e-19

long-chain fatty acid--CoA ligase;

Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 95.71 E-value: 1.71e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAKTGGAYV 2644
Cdd:PRK08751    26 TVAEVFATSVAKFADRPAY-HSFGKTITYREADQLVEQFAAYLLGElQLKKGDRVALMMPNCLQYPIATFGVLRAGLTVV 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2645 PIDPDYPAERVASMIEDSGAvlglSVLASGDLPGQEFEWMrLDDDSVAAEIAA------------------------VPA 2700
Cdd:PRK08751   105 NVNPLYTPRELKHQLIDSGA----SVLVVIDNFGTTVQQV-IADTPVKQVITTglgdmlgfpkaalvnfvvkyvkklVPE 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2701 GPITDAERLGEVTAA--------------NLAYVIYTSGSTGRPKGVAVTHSGL-ANFAR-----QESDRLNAGDNPVVl 2760
Cdd:PRK08751   180 YRINGAIRFREALALgrkhsmptlqiepdDIAFLQYTGGTTGVAKGAMLTHRNLvANMQQahqwlAGTGKLEEGCEVVI- 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2761 gfaspsfDASVLEYLLATVNEGT----------LAYRPSEaVGGEVLE----RFIAEHGATHTFltPSVLST--MDPTAV 2824
Cdd:PRK08751   259 -------TALPLYHIFALTANGLvfmkiggcnhLISNPRD-MPGFVKElkktRFTAFTGVNTLF--NGLLNTpgFDQIDF 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2825 PSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMP 2902
Cdd:PRK08751   329 SSLKMTLGGGMAVQRSVAERWKQVTglTLVEAYGLTETSPAACINPLTLKEYNGSIGLPIPSTDACIKDDAGTVLAIGEI 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2903 GELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIE 2982
Cdd:PRK08751   409 GELCIKGPQVMKGYWKRPEETAKVMDADGW-------LHTGDIAR----MDEQGF-VYIVDRKKDMILVSGFNVYPNEIE 476

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 2983 AVLAEHDAVESAVVLGVGGSVA-TALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK08751   477 DVIAMMPGVLEVAAVGVPDEKSgEIVKVVIVKKDPALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRREL 554

PRK08315

AMP-binding domain protein; Validated

1050-1524

1.76e-19

AMP-binding domain protein; Validated

Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 95.65 E-value: 1.76e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALI-CD-GTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:PRK08315    30 PDREALVyRDqGLRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPEWVLTQFATAKIGAILVTINPAYRLSELEY 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDASTR-------------------------ARL----------GESSCEWVDLADLEAEAESGDDITD 1172
Cdd:PRK08315   110 ALNQSGCKALIAADGFKdsdyvamlyelapelatcepgqlqsARLpelrrviflgDEKHPGMLNFDELLALGRAVDDAEL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1173 TERNGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVD---FVNSLAKITtgtPEDepdtRI-LHVasP---SFDASMFEM 1245
Cdd:PRK08315   190 AARQATLDPDDPINIQYTSGTTGFPKGATLTHRNILNngyFIGEAMKLT---EED----RLcIPV--PlyhCFGMVLGNL 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1246 AwAIPAGHTLVIAPQADFAGDALATVleRDE-------VTDMIItpSVLAtvDPERAQY-VRNLATG---GEACPPELVE 1314
Cdd:PRK08315   261 A-CVTHGATMVYPGEGFDPLATLAAV--EEErctalygVPTMFI--AELD--HPDFARFdLSSLRTGimaGSPCPIEVMK 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1315 RWSER--GRRIFNCYGPTEATVWATRSRMTAgkPV-----TIGKPVDGFTVRVLD---GRlhEVPQGVVGELylstagLA 1384
Cdd:PRK08315   334 RVIDKmhMSEVTIAYGMTETSPVSTQTRTDD--PLekrvtTVGRALPHLEVKIVDpetGE--TVPRGEQGEL------CT 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1385 RGY---LG---RPGQTAVSFVADPFgepgarMYaTGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVA 1458
Cdd:PRK08315   404 RGYsvmKGywnDPEKTAEAIDADGW------MH-TGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLYTHPKIQ 476

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 1459 QSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGK 1524
Cdd:PRK08315   477 DVQVVGVPDEKYGE---EVCAWIILRPGATLTEEDVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGK 539

PRK07059

Long-chain-fatty-acid--CoA ligase; Validated

120-468

2.20e-19

Long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 95.09 E-value: 2.20e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  120 PANAAFTLFTSGSTGRPKAVVITHRGIAnrlaADIEQYDLTARDVFLYKAPITFDVSV-----REIF-------LPIAIG 187
Cdd:PRK07059   203 PDDVAFLQYTGGTTGVSKGATLLHRNIV----ANVLQMEAWLQPAFEKKPRPDQLNFVcalplYHIFaltvcglLGMRTG 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  188 AT-LVIAepgrhgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGA-GVGEL--TSLRLIQTGGEALTPPVARDlMVRLP 263
Cdd:PRK07059   279 GRnILIP------NPRDIPGFIKELKKYQVHIFPAVNTLYNALLNNpDFDKLdfSKLIVANGGGMAVQRPVAER-WLEMT 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  264 GTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERF 343
Cdd:PRK07059   352 GCPITEGYGLSETSPVATCNPVDATEFSGTIGLPLPSTEVSIRDDDGNDLPLGEPGEICIRGPQVMAGYWNRPDETAKVM 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  344 VADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYL 422
Cdd:PRK07059   432 TADGF-------FRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVASHPGVLEVAAvGVPDEHSGEAVKLFV 504

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616  423 APADVDV--DTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK07059   505 VKKDPALteEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRREL 552

FATP_FACS

cd05940

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...

1062-1508

2.91e-19

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 93.96 E-value: 2.91e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1062 MDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDA 1141
Cdd:cd05940      4 LTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHLVVDA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1142 strarlgesscewvdladleaeaesgdditdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGT 1221
Cdd:cd05940     84 -------------------------------------------ALYIYTSGTTGLPKAAIISHRRAWRGGAFFAGSGGAL 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1222 PEDepdtrILHVASPSFDASMFEMAWA--IPAGHTLVIAPQ---ADFAGDALAtvlERDEVTDMI--ITPSVLAT--VDP 1292
Cdd:cd05940    121 PSD-----VLYTCLPLYHSTALIVGWSacLASGATLVIRKKfsaSNFWDDIRK---YQATIFQYIgeLCRYLLNQppKPT 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1293 ERAQYVRnlATGGEACPPELVERWSERGR--RIFNCYGPTEATVWATRsrmTAGKPVTIGK----PVDGFTVRVL----- 1361
Cdd:cd05940    193 ERKHKVR--MIFGNGLRPDIWEEFKERFGvpRIAEFYAATEGNSGFIN---FFGKPGAIGRnpslLRKVAPLALVkydle 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1362 --------DGRLHEVPQGVVGELYLSTAGLAR--GYLGrPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRA 1431
Cdd:cd05940    268 sgepirdaEGRCIKVPRGEPGLLISRINPLEPfdGYTD-PAATEKKILRDVF-KKGDAWFNTGDLMRLDGEGFWYFVDRL 345

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1432 DHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTR-GGRKHtevVAYLVAKPGATIDSAAVLDEAAQHLAAHMVP 1508
Cdd:cd05940    346 GDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQVPGtDGRAG---MAAIVLQPNEEFDLSALAAHLEKNLPGYARP 420

PLN02574

4-coumarate--CoA ligase-like

117-468

3.59e-19

4-coumarate--CoA ligase-like

Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 94.52 E-value: 3.59e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  117 PTRPANAAFTLFTSGSTGRPKAVVITHRGianrLAADIE--------QYDLTARD-VFLYKAPItFDVSVREIFLP--IA 185
Cdd:PLN02574   194 VIKQDDVAAIMYSSGTTGASKGVVLTHRN----LIAMVElfvrfeasQYEYPGSDnVYLAALPM-FHIYGLSLFVVglLS 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  186 IGATLVIAepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAF-NEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPG 264
Cdd:PLN02574   269 LGSTIVVM---RRFDASDMVKVIDRFKVTHFPVVPPILMALtKKAKGVCGEVLKSLKQVSCGAAPLSGKFIQDFVQTLPH 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  265 TRLQNQYGPAEASIVVTIHRVT-QDDRVIPIGTPTRRVSARVLD---AALreVPIGVPGELYLGGVQLARGYAGRPDLTA 340
Cdd:PLN02574   346 VDFIQGYGMTESTAVGTRGFNTeKLSKYSSVGLLAPNMQAKVVDwstGCL--LPPGNCGELWIQGPGVMKGYLNNPKATQ 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  341 ERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAA-AAVVDGPGGQQLV 419
Cdd:PLN02574   424 STIDKDGW-------LRTGDIAYFDEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAvTAVPDKECGEIPV 496

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616  420 GY--------LAPADVdVDTVAATTAellpEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PLN02574   497 AFvvrrqgstLSQEAV-INYVAKQVA----PYKKVRKVVFVQSIPKSPAGKILRREL 548

PRK09029

O-succinylbenzoic acid--CoA ligase; Provisional

1050-1466

4.95e-19

O-succinylbenzoic acid--CoA ligase; Provisional

Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 93.01 E-value: 4.95e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPAD------ 1123
Cdd:PRK09029    17 PQAIALRLNDEVLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQPlleell 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1124 -----RIAYMLEDSGATVGITDASTRARLGESSCEWvdladleaeaesgdditdterngsvRLTNLAYLIYTSGSTGRPK 1198
Cdd:PRK09029    97 psltlDFALVLEGENTFSALTSLHLQLVEGAHAVAW-------------------------QPQRLATMTLTSGSTGLPK 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1199 AvgVSHT---------GIVDFVNSLAKittgtpedepDTRILHVasPSFDASMFEMAWA-IPAGHTLVIAPQADFAgDAL 1268
Cdd:PRK09029   152 A--AVHTaqahlasaeGVLSLMPFTAQ----------DSWLLSL--PLFHVSGQGIVWRwLYAGATLVVRDKQPLE-QAL 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1269 ATV---------LER--DEVTDMIITPSVLatvdperaqyvrnlaTGGEACPPELVERWSERGRRIFNCYGPTEA--TVW 1335
Cdd:PRK09029   217 AGCthaslvptqLWRllDNRSEPLSLKAVL---------------LGGAAIPVELTEQAEQQGIRCWCGYGLTEMasTVC 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1336 ATRSRMTAGkpvtIGKPVDGFTVRVLDgrlhevpqgvvGELYLSTAGLARGYLgRPGQTaVSFVadpfGEPGarMYATGD 1415
Cdd:PRK09029   282 AKRADGLAG----VGSPLPGREVKLVD-----------GEIWLRGASLALGYW-RQGQL-VPLV----NDEG--WFATRD 338

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1416 LVRVAkGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVE 1466
Cdd:PRK09029   339 RGEWQ-NGELTILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFVVPVA 388

PRK12492

long-chain-fatty-acid--CoA ligase; Provisional

1051-1533

5.12e-19

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 94.12 E-value: 5.12e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1051 DHPALICDGTEMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK12492    39 DRPAFSNLGVTLSYAELERHSAAFAAYLQQHtDLVPGDRIAVQMPNVLQYPIAVFGALRAGLIVVNTNPLYTAREMRHQF 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGAT----VGITDASTRARLGESSCEW---VDLADLEAEAESG--DDITDTE-------------------RNG---- 1177
Cdd:PRK12492   119 KDSGARalvyLNMFGKLVQEVLPDTGIEYlieAKMGDLLPAAKGWlvNTVVDKVkkmvpayhlpqavpfkqalRQGrgls 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1178 ----SVRLTNLAYLIYTSGSTGRPKAVGVSHTGIV-DFVNSLAKITTGTPEDEPDTR----ILHVASPSFDASMFE---M 1245
Cdd:PRK12492   199 lkpvPVGLDDIAVLQYTGGTTGLAKGAMLTHGNLVaNMLQVRACLSQLGPDGQPLMKegqeVMIAPLPLYHIYAFTancM 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1246 AWAIPAGHTLVIAPQADFAGdaLATVLERDEVTDMI-ITPSVLATVD-PERAQY----VRNLATGGEACPPELVERWSE- 1318
Cdd:PRK12492   279 CMMVSGNHNVLITNPRDIPG--FIKELGKWRFSALLgLNTLFVALMDhPGFKDLdfsaLKLTNSGGTALVKATAERWEQl 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1319 RGRRIFNCYGPTEAT-VWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVS 1397
Cdd:PRK12492   357 TGCTIVEGYGLTETSpVASTNPYGELARLGTVGIPVPGTALKVIDDDGNELPLGERGELCIKGPQVMKGYWQQPEATAEA 436

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1398 FVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteV 1477
Cdd:PRK12492   437 LDAEGW-------FKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVMAHPKVANCAAIGVPDERSGEA---V 506

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 1478 VAYLVAK-PGATIDSAAVLdeAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEP 1533
Cdd:PRK12492   507 KLFVVARdPGLSVEELKAY--CKENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDI 561

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

1176-1526

6.29e-19

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 94.99 E-value: 6.29e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1176 NGSVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVAsPSFDASMFEMAWAIPA--GH 1253
Cdd:PRK08633   776 GPTFKPDDTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNLRNDD----VILSSL-PFFHSFGLTVTLWLPLleGI 850

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1254 TLVIAPQ-ADfaGDALATVLERDEVTDMIITPSVLAT------VDPERAQYVRNLATGGEACPPELVERWSER-GRRIFN 1325
Cdd:PRK08633   851 KVVYHPDpTD--ALGIAKLVAKHRATILLGTPTFLRLylrnkkLHPLMFASLRLVVAGAEKLKPEVADAFEEKfGIRILE 928

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1326 CYGPTEATVWATRS----------RMTAGKPVTIGKPVDGFTVRVLD-GRLHEVPQGVVGELYLSTAGLARGYLGRPGQT 1394
Cdd:PRK08633   929 GYGATETSPVASVNlpdvlaadfkRQTGSKEGSVGMPLPGVAVRIVDpETFEELPPGEDGLILIGGPQVMKGYLGDPEKT 1008

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1395 AvSFVADPfgePGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIE----AVLDAQPGVAqsVVVGVESTRG 1470
Cdd:PRK08633  1009 A-EVIKDI---DGIGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEeelaKALGGEEVVF--AVTAVPDEKK 1082

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 1471 GrkhtEVVAYLVAKPgaTIDSAAVLDE-AAQHLAAHMVPSQAIVIDEIPLTPAGKLD 1526
Cdd:PRK08633  1083 G----EKLVVLHTCG--AEDVEELKRAiKESGLPNLWKPSRYFKVEALPLLGSGKLD 1133

PRK05691

peptide synthase; Validated

2564-3145

7.44e-19

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 95.24 E-value: 7.44e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAV-----VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALaIGRSAQLLTAIWAVAK 2638
Cdd:PRK05691     8 PLTLVQALQRRAAQTPDRLALrfladDPGEGVVLSYRDLDLRARTIAAALQARASFGDRAVLL-FPSGPDYVAAFFGCLY 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2639 TGGAYVPIDPDYPA-----ERVASMIEDSGAVLGLSVLASGDlPGQEFEWMRLDDdsvAAEIAAVPAGPITDAERLGE-- 2711
Cdd:PRK05691    87 AGVIAVPAYPPESArrhhqERLLSIIADAEPRLLLTVADLRD-SLLQMEELAAAN---APELLCVDTLDPALAEAWQEpa 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2712 VTAANLAYVIYTSGSTGRPKGVAVTHSGL-AN--FARQeSDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRP 2788
Cdd:PRK05691   163 LQPDDIAFLQYTSGSTALPKGVQVSHGNLvANeqLIRH-GFGIDLNPDDVIVSWLPLYHDMGLIGGLLQPIFSGVPCVLM 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2789 SEAVggeVLER------FIAEHGAT------------HTFLTPSVLSTMDptaVPSLRVIAAGGEAVPQPIVDRWAP--- 2847
Cdd:PRK05691   242 SPAY---FLERplrwleAISEYGGTisggpdfayrlcSERVSESALERLD---LSRWRVAYSGSEPIRQDSLERFAEkfa 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2848 -----ATELHNLYGPTETTIGITIS------SAMR------------PGDPVRL---GGPIGGVDLMVLD-ERLRPVPVG 2900
Cdd:PRK05691   316 acgfdPDSFFASYGLAEATLFVSGGrrgqgiPALEldaealarnraePGTGSVLmscGRSQPGHAVLIVDpQSLEVLGDN 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2901 MPGELYVAGGALSRGYLDRSGLTAERFTANpygtAGQRMYRTGDVvrwtpdtdtGGL---TLEYTGRSDDQVKLRGLRIE 2977
Cdd:PRK05691   396 RVGEIWASGPSIAHGYWRNPEASAKTFVEH----DGRTWLRTGDL---------GFLrdgELFVTGRLKDMLIVRGHNLY 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2978 LGEIEAVlaehdaVESAVVLGVGGSVatalAAYIVPVDG------AVEVSE-----------LKAFAGGRLPAYM-VPSS 3039
Cdd:PRK05691   463 PQDIEKT------VEREVEVVRKGRV----AAFAVNHQGeegigiAAEISRsvqkilppqalIKSIRQAVAEACQeAPSV 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3040 FTVID--ELPLTPVGKLdKRALPEPVLEAGEYVA----PATGTERTIADVAAG-------------VLNIDAglVSATSS 3100
Cdd:PRK05691   533 VLLLNpgALPKTSSGKL-QRSACRLRLADGSLDSyalfPALQAVEAAQTAASGdelqariaaiwceQLKVEQ--VAADDH 609

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616 3101 FFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAETVG 3145
Cdd:PRK05691   610 FFLLGGNSIAATQVVARLRDELGIDLNLRQLFEAPTLAAFSAAVA 654

PRK07059

Long-chain-fatty-acid--CoA ligase; Validated

1050-1530

9.88e-19

Long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 93.16 E-value: 9.88e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK07059    37 ADRPAFICMGKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAVLRAGYVVVNVNPLYTPRELEHQL 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGA-----------TVGITDASTR------ARLGE-----------------------SSCEWVDLADLEAEAE---- 1165
Cdd:PRK07059   117 KDSGAeaivvlenfatTVQQVLAKTAvkhvvvASMGDllgfkghivnfvvrrvkkmvpawSLPGHVRFNDALAEGArqtf 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1166 -----SGDDItdterngsvrltnlAYLIYTSGSTGRPKAVGVSHTGIVDFV--NSLAKITTGTPEDEPDTRILHVASPSF 1238
Cdd:PRK07059   197 kpvklGPDDV--------------AFLQYTGGTTGVSKGATLLHRNIVANVlqMEAWLQPAFEKKPRPDQLNFVCALPLY 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1239 D------ASMFEMAwaiPAGHTLVIAPQADFAGdaLATVLERDEVTdmiITPSV-------LATVDPERAQYVRNLAT-- 1303
Cdd:PRK07059   263 HifaltvCGLLGMR---TGGRNILIPNPRDIPG--FIKELKKYQVH---IFPAVntlynalLNNPDFDKLDFSKLIVAng 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1304 GGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSRMTAGK-PVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTA 1381
Cdd:PRK07059   335 GGMAVQRPVAERWLEMtGCPITEGYGLSETSPVATCNPVDATEfSGTIGLPLPSTEVSIRDDDGNDLPLGEPGEICIRGP 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1382 GLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSV 1461
Cdd:PRK07059   415 QVMAGYWNRPDETAKVMTADGF-------FRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVASHPGVLEVA 487

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1462 VVGVESTRGGrkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK07059   488 AVGVPDEHSG----EAVKLFVVKKDPALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRREL 552

FadD3

cd17638

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...

127-463

1.22e-18

Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 89.87 E-value: 1.22e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  127 LFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAI-GATLViaePGRHGDPVHLA 205
Cdd:cd17638      6 MFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDDRYLIINPFFHTFGYKAGIVACLLtGATVV---PVAVFDVDAIL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 DLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEAsIVVTIHRv 285
Cdd:cd17638     83 EAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMRSELGFETVLTAYGLTEA-GVATMCR- 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  286 tQDDRVIPIGTPTRRVSARVldaalrEVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWN 365
Cdd:cd17638    161 -PGDDAETVATTCGRACPGF------EVRIADDGEVLVRGYNVMQGYLDDPEATAEAIDADGW-------LHTGDVGELD 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  366 RDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVD----GPGGQQLVGYLAPADVDVDTVAATTAELLP 441
Cdd:cd17638    227 ERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPdermGEVGKAFVVARPGVTLTEEDVIAWCRERLA 306

                          330       340
                   ....*....|....*....|..
gi 1827387616  442 EYMRPSAWVRLDAMPLSRSGKV 463
Cdd:cd17638    307 NYKVPRFVRFLDELPRNASGKV 328

PRK06060

p-hydroxybenzoic acid--AMP ligase FadD22;

2592-3142

1.30e-18

p-hydroxybenzoic acid--AMP ligase FadD22;

Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 93.17 E-value: 1.30e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLglsVL 2671
Cdd:PRK06060    31 VTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPAL---VV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 ASGDLpgqefewmrldDDSVAAEIAAVPAGPITDAERLGE-----VTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR- 2745
Cdd:PRK06060   108 TSDAL-----------RDRFQPSRVAEAAELMSEAARVAPggyepMGGDALAYATYTSGTTGPPKAAIHRHADPLTFVDa 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2746 --QESDRLNAGDnpVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPS----VLSTM 2819
Cdd:PRK06060   177 mcRKALRLTPED--TGLCSARMYFAYGLGNSVWFPLATGGSAVINSAPVTPEAAAILSARFGPSVLYGVPNffarVIDSC 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2820 DPTAVPSLRVIAAGGEAVPQPIVDRwapATELHN----LYGPTETTIGIT-ISSAMRPGDPVRLGGPIGGVDLMVLDERL 2894
Cdd:PRK06060   255 SPDSFRSLRCVVSAGEALELGLAER---LMEFFGgipiLDGIGSTEVGQTfVSNRVDEWRLGTLGRVLPPYEIRVVAPDG 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2895 RPVPVGMPGELYVAGGALSRGYLDRSgltaerftaNPYGTAGQRMyRTGDVVRWTPDtdtGGLTleYTGRSDDQVKLRGL 2974
Cdd:PRK06060   332 TTAGPGVEGDLWVRGPAIAKGYWNRP---------DSPVANEGWL-DTRDRVCIDSD---GWVT--YRCRADDTEVIGGV 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2975 RIELGEIEAVLAEHDAVESAVVLGVGGSV-ATALAAYIVP-----VDGAVeVSELKAFAGGRLPAYMVPSSFTVIDELPL 3048
Cdd:PRK06060   397 NVDPREVERLIIEDEAVAEAAVVAVRESTgASTLQAFLVAtsgatIDGSV-MRDLHRGLLNRLSAFKVPHRFAVVDRLPR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3049 TPVGKLDKRAL-----PEPVLE------------------AGEYVAPATGT----------------ERTIADVAAG--- 3086
Cdd:PRK06060   476 TPNGKLVRGALrkqspTKPIWElsltepgsgvraqrddlsASNMTIAGGNDggatlrerlvalrqerQRLVVDAVCAeaa 555

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 3087 --VLNIDAGLVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAE 3142
Cdd:PRK06060   556 kmLGEPDPWSVDQDLAFSELGFDSQMTVTLCKRLAAVTGLRLPETVGWDYGSISGLAQ 613

PRK05852

fatty acid--CoA ligase family protein;

1015-1532

1.83e-18

fatty acid--CoA ligase family protein;

Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 92.26 E-value: 1.83e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1015 VSAPVSARTPGAMVGRGgeveAGTLIDVLAQRDldPDHPALIC--DGTEMDYDEFETRTNAIARALLARGVSPEDVVAVG 1092
Cdd:PRK05852     1 MRFMGGAAPMASDFGPR----IADLVEVAATRL--PEAPALVVtaDRIAISYRDLARLVDDLAGQLTRSGLLPGDRVALR 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1093 MERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGESSCEWVDLA------DLEAEAES 1166
Cdd:PRK05852    75 MGSNAEFVVALLAASRADLVVVPLDPALPIAEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTvnvggdSGPSGGTL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1167 GDDITDTERNGSVRLTNL------AYLIYTSGSTGRPKAVGVSHTGIVDFVNSlakITTGTPEDEPDTRIlhVASPSFDA 1240
Cdd:PRK05852   155 SVHLDAATEPTPATSTPEglrpddAMIMFTGGTTGLPKMVPWTHANIASSVRA---IITGYRLSPRDATV--AVMPLYHG 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1241 S--MFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSV----LATVDPERAQYVRNLATGGEACPPELVE 1314
Cdd:PRK05852   230 HglIAALLATLASGGAVLLPARGRFSAHTFWDDIKAVGATWYTAVPTIhqilLERAATEPSGRKPAALRFIRSCSAPLTA 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1315 RWSERGRRIFNC-----YGPTEATVWATRSRMTAG----KPVTIGKPVD---GFTVRVLDGRLHEVPQGVVGELYLSTAG 1382
Cdd:PRK05852   310 ETAQALQTEFAApvvcaFGMTEATHQVTTTQIEGIgqteNPVVSTGLVGrstGAQIRIVGSDGLPLPAGAVGEVWLRGTT 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1383 LARGYLGRPGQTAVSFVADPFgepgarmyATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVV 1462
Cdd:PRK05852   390 VVRGYLGDPTITAANFTDGWL--------RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAV 461

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1463 VGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK05852   462 FGVPDQLYGE---AVAAVIVPRESAPPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAE 528

PRK12582

acyl-CoA synthetase; Provisional

1-439

2.03e-18

acyl-CoA synthetase; Provisional

Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 92.42 E-value: 2.03e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVV----AIHA---VA--------MAGGH-------------F 52
Cdd:PRK12582    81 VTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEHALmtlaAMQAgvpAApvspayslMSHDHaklkhlfdlvkprV 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   53 VPLDEQLPVDRARYMVRTAGVRLVVVTSDGEAEARSRFDDIVdvhvldiSSPGDADLdEEEFAGPTrPANAAFTLFTSGS 132
Cdd:PRK12582   161 VFAQSGAPFARALAALDLLDVTVVHVTGPGEGIASIAFADLA-------ATPPTAAV-AAAIAAIT-PDTVAKYLFTSGS 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  133 TGRPKAVVITHRGIANRLAAdieQYDLTARD------VFLYKAPITFDVSVREIFLPIAI-GATLVIAE----PGRHGDP 201
Cdd:PRK12582   232 TGMPKAVINTQRMMCANIAM---QEQLRPREpdppppVSLDWMPWNHTMGGNANFNGLLWgGGTLYIDDgkplPGMFEET 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  202 VHladLIRRHGVTVIHFVPAMLAAF------NEVLGAGVgeLTSLRLIQTGGEALTPPV---ARDLMVRLPGTR--LQNQ 270
Cdd:PRK12582   309 IR---NLREISPTVYGNVPAGYAMLaeamekDDALRRSF--FKNLRLMAYGGATLSDDLyerMQALAVRTTGHRipFYTG 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  271 YGPAEAS-IVVTIHRVTqdDRVIPIGTPTRRVsarvldaALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFg 349
Cdd:PRK12582   384 YGATETApTTTGTHWDT--ERVGLIGLPLPGV-------ELKLAPVGDKYEVRVKGPNVTPGYHKDPELTAAAFDEEGF- 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  350 epgarlYRTGDRARW--NRDGE--IEYLGRTDFQVKL-RGQRLELGEVEA-ALAAAPGVLHaaAAVVDG----------- 412
Cdd:PRK12582   454 ------YRLGDAARFvdPDDPEkgLIFDGRVAEDFKLsTGTWVSVGTLRPdAVAACSPVIH--DAVVAGqdrafigllaw 525

                          490       500       510
                   ....*....|....*....|....*....|
gi 1827387616  413 ---PGGQQLVGYLAPADVDVDTVAATTAEL 439
Cdd:PRK12582   526 pnpAACRQLAGDPDAAPEDVVKHPAVLAIL 555

NRPS-para261

TIGR01720

non-ribosomal peptide synthase domain TIGR01720; This domain appears to be located immediately ...

1942-2097

2.35e-18

non-ribosomal peptide synthase domain TIGR01720; This domain appears to be located immediately downstream from a condensation domain (pfam00668), and is followed primarily by the end of the molecule or another condensation domain (in a few cases it is followed by pfam00501, an AMP-binding module). The converse is not true, pfam00668 domains are not always followed by this domain. This implicates this domain in possible post-condensation modification events. This model is 171 amino acids long and contains three very highly conserved regions. At the N-terminus is a nearly invariant lysine (position 11) followed by xxxRxxPxxGxGYG in which the proline and the first glycine are invariant. This is followed approximately 22 residues later by the motif FNYLG. Near the C-terminus of the domain is the sequence TxSD where the serine and aspartate are nearly invariant.

Pssm-ID: 273774 [Multi-domain] Cd Length: 153 Bit Score: 84.25 E-value: 2.35e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1942 HAVKSAKDARLSRPAGGVGFGILRY--NSDGEIAHRPLPTIMYNYFGGGTAPSTEtapDDFLPVSDRPNmpSSITGAMRS 2019
Cdd:TIGR01720    4 RLIKAVKEQLRRIPNKGVGYGVLRYltEPEEKLAASPQPEISFNYLGQFDADSND---ELFQPSSYSPG--EAISPESPR 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 2020 PSVFGINistAGREERRLEAKVTYATDALDEAAASDIARRWHDELRAVVELVDGGAEIGLSRADVPGVEVTQDDLDLI 2097
Cdd:TIGR01720   79 PYALEIN---AMIEDGELTLTWSYPTQLFSEDTIEQLADRFKEALEALIAHCAGKEGGGLTPSDFSLKDLTQDELDEL 153

PRK08974

long-chain-fatty-acid--CoA ligase FadD;

1050-1530

3.15e-18

long-chain-fatty-acid--CoA ligase FadD;

Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 91.65 E-value: 3.15e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARAL-----LARGvspeDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADR 1124
Cdd:PRK08974    37 ADQPAFINMGEVMTFRKLEERSRAFAAYLqnglgLKKG----DRVALMMPNLLQYPIALFGILRAGMIVVNVNPLYTPRE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1125 IAYMLEDSGAT--VGITD-ASTRARLGESSC-EWVDLADLeaeaesGDDITDTER---NGSVRL---------------- 1181
Cdd:PRK08974   113 LEHQLNDSGAKaiVIVSNfAHTLEKVVFKTPvKHVILTRM------GDQLSTAKGtlvNFVVKYikrlvpkyhlpdaisf 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1182 -------------------TNLAYLIYTSGSTGRPKAVGVSHTGIVdfVNSLAKITTGTPEDEPDTRIL-------HVAS 1235
Cdd:PRK08974   187 rsalhkgrrmqyvkpelvpEDLAFLQYTGGTTGVAKGAMLTHRNML--ANLEQAKAAYGPLLHPGKELVvtalplyHIFA 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1236 PSFDASMF-EMAwaipaGHTLVIAPQADFagDALATVLERDEVTDMIITPSVL-ATVDPERAQYV-----RNLATGGEAC 1308
Cdd:PRK08974   265 LTVNCLLFiELG-----GQNLLITNPRDI--PGFVKELKKYPFTAITGVNTLFnALLNNEEFQELdfsslKLSVGGGMAV 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1309 PPELVERWSE-RGRRIFNCYGPTEAtvwatrSRMTAGKPV-------TIGKPVDGFTVRVLDGRLHEVPQGVVGELYLST 1380
Cdd:PRK08974   338 QQAVAERWVKlTGQYLLEGYGLTEC------SPLVSVNPYdldyysgSIGLPVPSTEIKLVDDDGNEVPPGEPGELWVKG 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1381 AGLARGYLGRPGQTAvSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQS 1460
Cdd:PRK08974   412 PQVMLGYWQRPEATD-EVIKDGW-------LATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKVLEV 483

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1461 VVVGVESTRGGrkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK08974   484 AAVGVPSEVSG----EAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRREL 549

PrpE

cd05967

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...

127-468

3.23e-18

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.

Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 91.61 E-value: 3.23e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  127 LFTSGSTGRPKAVVITHRGIANRLAADIEQ-YDLTARDVFLYKAPITFDVSVREI-FLPIAIGATLVIAE--PGRHGDPV 202
Cdd:cd05967    236 LYTSGTTGKPKGVVRDNGGHAVALNWSMRNiYGIKPGDVWWAASDVGWVVGHSYIvYGPLLHGATTVLYEgkPVGTPDPG 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  203 HLADLIRRHGVTVIHFVPAMLAAF-----NEVLGAGVgELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNqYGPAEAS 277
Cdd:cd05967    316 AFWRVIEKYQVNALFTAPTAIRAIrkedpDGKYIKKY-DLSSLRTLFLAGERLDPPTLEWAENTLGVPVIDH-WWQTETG 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  278 IVVTIHRVTQDDRVIPIGTPTRRV---SARVLDAALREVPIGVPGELYLGGvQLARGYAGRPDLTAERFVADPFGE-PGa 353
Cdd:cd05967    394 WPITANPVGLEPLPIKAGSPGKPVpgyQVQVLDEDGEPVGPNELGNIVIKL-PLPPGCLLTLWKNDERFKKLYLSKfPG- 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  354 rLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPadvdVDTV 432
Cdd:cd05967    472 -YYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPAVAECAVvGVRDELKGQVPLGLVVL----KEGV 546

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616  433 AATTAELLPEYMR-------PSAWVRL----DAMPLSRSGKVDRRLL 468
Cdd:cd05967    547 KITAEELEKELVAlvreqigPVAAFRLvifvKRLPKTRSGKILRRTL 593

Firefly_Luc

cd17642

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...

1059-1532

4.06e-18

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.

Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 91.05 E-value: 4.06e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1059 GTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATV-- 1136
Cdd:cd17642     42 GVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFFLPVIAGLFIGVGVAPTNDIYNERELDHSLNISKPTIvf 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1137 --------------------GITDASTRARLGESSCewvDLADLEAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGR 1196
Cdd:cd17642    122 cskkglqkvlnvqkklkiikTIIILDSKEDYKGYQC---LYTFITQNLPPGFNEYDFKPPSFDRDEQVALIMNSSGSTGL 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1197 PKAVGVSHTGIVDFVNSLAKITTGTpEDEPDTRILHVAsPSFDA-SMFEMAWAIPAGHTLVIAPQadFAGDALATVLERD 1275
Cdd:cd17642    199 PKGVQLTHKNIVARFSHARDPIFGN-QIIPDTAILTVI-PFHHGfGMFTTLGYLICGFRVVLMYK--FEEELFLRSLQDY 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1276 EVTDMIITPSVLA------TVDPERAQYVRNLATGGEACPPELVERWSERGRRIF--NCYGPTEATVWATRSRMTAGKPV 1347
Cdd:cd17642    275 KVQSALLVPTLFAffakstLVDKYDLSNLHEIASGGAPLSKEVGEAVAKRFKLPGirQGYGLTETTSAILITPEGDDKPG 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1348 TIGKPVDGFTVRVLD---GRLHEVPQgvVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGN 1424
Cdd:cd17642    355 AVGKVVPFFYAKVVDldtGKTLGPNE--RGELCVKGPMIMKGYVNNPEATKALIDKDGW-------LHSGDIAYYDEDGH 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1425 LEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVaylVAKPGATIDSAAVLD-EAAQHLA 1503
Cdd:cd17642    426 FFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDAGVAGIPDEDAGELPAAVV---VLEAGKTMTEKEVMDyVASQVST 502

                          490       500
                   ....*....|....*....|....*....
gi 1827387616 1504 AHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:cd17642    503 AKRLRGGVKFVDEVPKGLTGKIDRRKIRE 531

MACS_like_1

cd05974

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1064-1463

5.00e-18

Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 89.93 E-value: 5.00e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVgmerSIGSVLATW----GVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT 1139
Cdd:cd05974      3 FAEMSARSSRVANFLRSIGVGRGDRILL----MLGNVVELWeamlAAMKLGAVVIPATTLLTPDDLRDRVDRGGAVYAAV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DASTRArlgesscewvdladleaeaesgDDITdterngsvrltnlaYLIYTSGSTGRPKAVGVSHTGI-VDFVNSLAKIT 1218
Cdd:cd05974     79 DENTHA----------------------DDPM--------------LLYFTSGTTSKPKLVEHTHRSYpVGHLSTMYWIG 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1219 TgtpedEPDTRILHVASPSFDA---SMFEMAWAipAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSV---LATVDP 1292
Cdd:cd05974    123 L-----KPGDVHWNISSPGWAKhawSCFFAPWN--AGATVFLFNYARFDAKRVLAALVRYGVTTLCAPPTVwrmLIQQDL 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1293 ERAQY-VRNLATGGEACPPELVER----WserGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHE 1367
Cdd:cd05974    196 ASFDVkLREVVGAGEPLNPEVIEQvrraW---GLTIRDGYGQTETTALVGNSPGQPVKAGSMGRPLPGYRVALLDPDGAP 272

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1368 VPQGVVGeLYLST---AGLARGYLGRPGQTAvsfvadpfGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVEL 1444
Cdd:cd05974    273 ATEGEVA-LDLGDtrpVGLMKGYAGDPDKTA--------HAMRGGYYRTGDIAMRDEDGYLTYVGRADDVFKSSDYRISP 343

                          410
                   ....*....|....*....
gi 1827387616 1445 GEIEAVLDAQPGVAQSVVV 1463
Cdd:cd05974    344 FELESVLIEHPAVAEAAVV 362

PRK07867

acyl-CoA synthetase; Validated

1036-1530

5.03e-18

acyl-CoA synthetase; Validated

Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 90.51 E-value: 5.03e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1036 AGTLIDVLAQRdLDPDHPALICDGTEMDYDEFETRTNAIA---RALLARGVSPEdvVAVGMERSIGSVLATWGVIKSGAA 1112
Cdd:PRK07867     4 APTVAELLLPL-AEDDDRGLYFEDSFTSWREHIRGSAARAaalRARLDPTRPPH--VGVLLDNTPEFSLLLGAAALSGIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1113 YVPVDPAYPADRIAYMLEDSGATVGITDASTRARLGE----------SSCEWVDLADLEAEAEsgdditdtERNGSVRLT 1182
Cdd:PRK07867    81 PVGLNPTRRGAALARDIAHADCQLVLTESAHAELLDGldpgvrvinvDSPAWADELAAHRDAE--------PPFRVADPD 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSF--DASMFEMAWAIPAGHTLVI--- 1257
Cdd:PRK07867   153 DLFMLIFTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDD-----VCYVSMPLFhsNAVMAGWAVALAAGASIALrrk 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1258 --------------APQADFAGDALATVLERDEVtdmiitpsvlatvdPERAQYVRNLATGGEACPPElVERWSER-GRR 1322
Cdd:PRK07867   228 fsasgflpdvrrygATYANYVGKPLSYVLATPER--------------PDDADNPLRIVYGNEGAPGD-IARFARRfGCV 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1323 IFNCYGPTEATVWATRSRMTagKPVTIGKPVDGFTVRVLDGRlHEVPQGV------------VGELYLST-AGLARGYLG 1389
Cdd:PRK07867   293 VVDGFGSTEGGVAITRTPDT--PPGALGPLPPGVAIVDPDTG-TECPPAEdadgrllnadeaIGELVNTAgPGGFEGYYN 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1390 RPGQTAvsfvadpfgepgARM----YATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV 1465
Cdd:PRK07867   370 DPEADA------------ERMrggvYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAV 437

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1466 -ESTRGGRkhteVVAYLVAKPGATIDSAAV---LDEAAQhLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK07867   438 pDPVVGDQ----VMAALVLAPGAKFDPDAFaefLAAQPD-LGPKQWPSYVRVCAELPRTATFKVLKRQL 501

AcpA

COG3433

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...

1358-1607

5.47e-18

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442659 [Multi-domain] Cd Length: 295 Bit Score: 87.50 E-value: 5.47e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1358 VRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKI 1437
Cdd:COG3433     25 VQARALLLIVDLQGYFGGFGGEGGLLGAGLLLRIRLLAAAARAPFIPVPYPAQPGRQADDLRLLLRRGLGPGGGLERLVQ 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1438 NGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEI 1517
Cdd:COG3433    105 QVVIRAERGEEEELLLVLRAAAVVRVAVLAALRGAGVGLLLIVGAVAALDGLAAAAALAALDKVPPDVVAASAVVALDAL 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1518 PLTPAGKLDRAALPEPHAPEPAEYVAPANPAEDN-----LARIVAGLLGE--ERVSVTESFFALGGDSIMSIQLSSAAKA 1590
Cdd:COG3433    185 LLLALKVVARAAPALAAAEALLAAASPAPALETAlteeeLRADVAELLGVdpEEIDPDDNLFDLGLDSIRLMQLVERWRK 264

                          250
                   ....*....|....*..
gi 1827387616 1591 AGIHLSPREIFELKTIR 1607
Cdd:COG3433    265 AGLDVSFADLAEHPTLA 281

PRK06018

putative acyl-CoA synthetase; Provisional

1064-1532

5.97e-18

putative acyl-CoA synthetase; Provisional

Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 90.58 E-value: 5.97e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVgMERSIGSVLATW-GVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITD-- 1140
Cdd:PRK06018    42 YAQIHDRALKVSQALDRDGIKLGDRVAT-IAWNTWRHLEAWyGIMGIGAICHTVNPRLFPEQIAWIINHAEDRVVITDlt 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1141 -----ASTRARLgESSCEWVDLADLE-------AEAESGDDITDtERNGSVRLTNL-----AYLIYTSGSTGRPKAVGVS 1203
Cdd:PRK06018   121 fvpilEKIADKL-PSVERYVVLTDAAhmpqttlKNAVAYEEWIA-EADGDFAWKTFdentaAGMCYTSGTTGDPKGVLYS 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1204 HTGivdfvNSLAKITTGTPE----DEPDTrILHVAsPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTD 1279
Cdd:PRK06018   199 HRS-----NVLHALMANNGDalgtSAADT-MLPVV-PLFHANSWGIAFSAPSMGTKLVMPGAKLDGASVYELLDTEKVTF 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1280 MIITPSV----LATVDPERAQ--YVRNLATGGEACPPELVERWSERGRRIFNCYGPTEATVWATRSRMTAG--------- 1344
Cdd:PRK06018   272 TAGVPTVwlmlLQYMEKEGLKlpHLKMVVCGGSAMPRSMIKAFEDMGVEVRHAWGMTEMSPLGTLAALKPPfsklpgdar 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 --KPVTIGKPVDGFTVRVLDGRLHEVPQG--VVGELYLSTAGLARGYLGRPGQTavsFVADPFgepgarmYATGDLVRVA 1420
Cdd:PRK06018   352 ldVLQKQGYPPFGVEMKITDDAGKELPWDgkTFGRLKVRGPAVAAAYYRVDGEI---LDDDGF-------FDTGDVATID 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1421 KGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVaylVAKPGATIDSAAVLDEAAQ 1500
Cdd:PRK06018   422 AYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKWDERPLLIV---QLKPGETATREEILKYMDG 498

                          490       500       510
                   ....*....|....*....|....*....|..
gi 1827387616 1501 HLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK06018   499 KIAKWWMPDDVAFVDAIPHTATGKILKTALRE 530

PRK06178

acyl-CoA synthetase; Validated

4-472

6.06e-18

acyl-CoA synthetase; Validated

Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 90.49 E-value: 6.06e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDeqlPVDRA---RYMVRTAGVRlVVVTS 80
Cdd:PRK06178    62 AELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVHVPVS---PLFREhelSYELNDAGAE-VLLAL 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAE------ARSRFDDIVDVHVLD------------------ISSPGDADLDEEEFAGPTRPANAAFTL-------FT 129
Cdd:PRK06178   138 DQLAPvveqvrAETSLRHVIVTSLADvlpaeptlplpdslraprLAAAGAIDLLPALRACTAPVPLPPPALdalaalnYT 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  130 SGSTGRPKAVVITHRGI-----ANRLAADIEQYDltarDVFLYKAPItFDVSVRE--IFLPIAIGATLVIAEpgrHGDPV 202
Cdd:PRK06178   218 GGTTGMPKGCEHTQRDMvytaaAAYAVAVVGGED----SVFLSFLPE-FWIAGENfgLLFPLFSGATLVLLA---RWDAV 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  203 HLADLIRRHGVTVIhfvpAMLA-AFNEVL---GAGVGELTSLRliQTGGEALTPPVARDLMVR---LPGTRL-QNQYGPA 274
Cdd:PRK06178   290 AFMAAVERYRVTRT----VMLVdNAVELMdhpRFAEYDLSSLR--QVRVVSFVKKLNPDYRQRwraLTGSVLaEAAWGMT 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  275 EASIVVTIHRVTQDD------RVIPIGTPTRRVSARVLDAALRE-VPIGVPGELYLGGVQLARGYAGRPDLTAERFVADp 347
Cdd:PRK06178   364 ETHTCDTFTAGFQDDdfdllsQPVFVGLPVPGTEFKICDFETGElLPLGAEGEIVVRTPSLLKGYWNKPEATAEALRDG- 442

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  348 fgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLhaAAAVV---DGPGGQQLVGY--L 422
Cdd:PRK06178   443 -------WLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEVEALLGQHPAVL--GSAVVgrpDPDKGQVPVAFvqL 513

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  423 AP-ADVDVDTVAATTAELLPEYMRPSAWVrLDAMPLSRSGKVDR-RLLPEPE 472
Cdd:PRK06178   514 KPgADLTAAALQAWCRENMAVYKVPEIRI-VDALPMTATGKVRKqDLQALAE 564

PRK06155

crotonobetaine/carnitine-CoA ligase; Provisional

4-470

6.15e-18

crotonobetaine/carnitine-CoA ligase; Provisional

Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 90.59 E-value: 6.15e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:PRK06155    50 AEAARAAAAAAHALAAAGVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAVPINTALRGPQLEHILRNSGARLLVVEAALL 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARS---RFDDIVDVHVLDISSPGDAD----------LDEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRG--IAN 148
Cdd:PRK06155   130 AALEAadpGDLPLPAVWLLDAPASVSVPagwstaplppLDAPAPAAAVQPGDTAAILYTSGTTGPSKGVCCPHAQfyWWG 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  149 RLAAdiEQYDLTARDVFLYKAPItFDVSVREIFLPIAI-GATLVIaepGRHGDPVHLADLIRRHGVTVIHFVPAMLaafn 227
Cdd:PRK06155   210 RNSA--EDLEIGADDVLYTTLPL-FHTNALNAFFQALLaGATYVL---EPRFSASGFWPAVRRHGATVTYLLGAMV---- 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  228 evlgagvgeltSLRLIQTGGE---------ALTPPVARDLMVRLP---GTRLQNQYGPAEASIVvtIHRVTQDDRVIPIG 295
Cdd:PRK06155   280 -----------SILLSQPAREsdrahrvrvALGPGVPAALHAAFRerfGVDLLDGYGSTETNFV--IAVTHGSQRPGSMG 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  296 TPTRRVSARVLDAALREVPIGVPGELYLGGVQ---LARGYAGRPDLTAERFVADPFgepgarlyRTGDRARWNRDGEIEY 372
Cdd:PRK06155   347 RLAPGFEARVVDEHDQELPDGEPGELLLRADEpfaFATGYFGMPEKTVEAWRNLWF--------HTGDRVVRDADGWFRF 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  373 LGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPAD---VDVDTVAATTAELLPEYMRPSA 448
Cdd:PRK06155   419 VDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAVfPVPSELGEDEVMAAVVLRDgtaLEPVALVRHCEPRLAYFAVPRY 498

                          490       500
                   ....*....|....*....|..
gi 1827387616  449 WVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK06155   499 VEFVAALPKTENGKVQKFVLRE 520

PRK07824

o-succinylbenzoate--CoA ligase;

1304-1530

7.29e-18

o-succinylbenzoate--CoA ligase;

Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 88.18 E-value: 7.29e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1304 GGEACPPELVERWSERGRRIFNCYGPTEatvwatrsrmTAGKPVTIGKPVDGFTVRVLDGRLHevpqgvvgelyLSTAGL 1383
Cdd:PRK07824   159 GGGPAPAPVLDAAAAAGINVVRTYGMSE----------TSGGCVYDGVPLDGVRVRVEDGRIA-----------LGGPTL 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1384 ARGYLGRPgqtavsfVADPFGEPGarMYATGDLVRVAKGgNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVV 1463
Cdd:PRK07824   218 AKGYRNPV-------DPDPFAEPG--WFRTDDLGALDDG-VLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVF 287

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 1464 GVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK07824   288 GLPDDRLGQR---VVAAVVGDGGPAPTLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRAL 351

PRK05677

long-chain-fatty-acid--CoA ligase; Validated

236-474

8.02e-18

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 90.21 E-value: 8.02e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  236 ELTSLRLIQTGGEALTPPVArDLMVRLPGTRLQNQYGPAEASIVVTIHRVtQDDRVIPIGTPTRRVSARVLDAALREVPI 315
Cdd:PRK05677   324 DFSALKLTLSGGMALQLATA-ERWKEVTGCAICEGYGMTETSPVVSVNPS-QAIQVGTIGIPVPSTLCKVIDDDGNELPL 401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  316 GVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:PRK05677   402 GEVGELCVKGPQVMKGYWQRPEATDEILDSDGW-------LKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDV 474

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  396 LAAAPGVLHAAA-AVVDGPGGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEP 471
Cdd:PRK05677   475 LAALPGVLQCAAiGVPDEKSGEAIKVFVVVkpgETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRRELRDE 554


                   ...
gi 1827387616  472 EIA 474
Cdd:PRK05677   555 ELK 557

PRK12406

long-chain-fatty-acid--CoA ligase; Provisional

1-474

8.96e-18

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 89.76 E-value: 8.96e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK12406    12 RSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLIAHA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 DGEAEARSRFDDivDVHVLDISSP------------------GDADLDE-----EEFAGPTRPANAAFtLFTSGSTGRPK 137
Cdd:PRK12406    92 DLLHGLASALPA--GVTVLSVPTPpeiaaayrispalltppaGAIDWEGwlaqqEPYDGPPVPQPQSM-IYTSGTTGHPK 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  138 AV-----VITHRGIANRLAADIEQYDLTARDVF---LY-KAPITFDVSVreiflpIAIGATLVIaEPgrHGDPVHLADLI 208
Cdd:PRK12406   169 GVrraapTPEQAAAAEQMRALIYGLKPGIRALLtgpLYhSAPNAYGLRA------GRLGGVLVL-QP--RFDPEELLQLI 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  209 RRHGVTVIHFVPAMLAAFNEvLGAGVGE---LTSLRLIqTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTihrV 285
Cdd:PRK12406   240 ERHRITHMHMVPTMFIRLLK-LPEEVRAkydVSSLRHV-IHAAAPCPADVKRAMIEWWGPVIYEYYGSTESGAVTF---A 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  286 TQDDRVIPIGT---PTRRVSARVLDAALREVPIGVPGELYlggvqlARgYAGRPDLTAErfvadpfGEPGARlyRTGDRA 362
Cdd:PRK12406   315 TSEDALSHPGTvgkAAPGAELRFVDEDGRPLPQGEIGEIY------SR-IAGNPDFTYH-------NKPEKR--AEIDRG 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  363 RWNRDGEIEYLGRTDF---------QVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAP---ADVDV 429
Cdd:PRK12406   379 GFITSGDVGYLDADGYlflcdrkrdMVISGGVNIYPAEIEAVLHAVPGVHDCAVfGIPDAEFGEALMAVVEPqpgATLDE 458

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1827387616  430 DTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEIA 474
Cdd:PRK12406   459 ADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDPYWA 503

AFD_YhfT-like

cd17633

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...

2716-3056

9.19e-18

Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 87.08 E-value: 9.19e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTH-SGLANFARQESD-RLNAGDNPVVLGFASPSFDasvLEYLLATVNEGTLAYRPSEAVG 2793
Cdd:cd17633      1 NPFYIGFTSGTTGLPKAYYRSErSWIESFVCNEDLfNISGEDAILAPGPLSHSLF---LYGAISALYLGGTFIGQRKFNP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2794 GEVLeRFIAEHGATHTFLTPSVLSTMDPTAVP--SLRVIAAGGEAVPQPI---VDRWAPATELHNLYGPTETTIgITISS 2868
Cdd:cd17633     78 KSWI-RKINQYNATVIYLVPTMLQALARTLEPesKIKSIFSSGQKLFESTkkkLKNIFPKANLIEFYGTSELSF-ITYNF 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2869 AMRPGDPVRLGGPIGGVDLmvldeRLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFtanpygtagqrmYRTGDVVRW 2948
Cdd:cd17633    156 NQESRPPNSVGRPFPNVEI-----EIRNADGGEIGKIFVKSEMVFSGYVRGGFSNPDGW------------MSVGDIGYV 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2949 TPDtdtGGLTLEytGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEvSELKAFAG 3028
Cdd:cd17633    219 DEE---GYLYLV--GRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIAVALYSGDKLTY-KQLKRFLK 292

                          330       340
                   ....*....|....*....|....*...
gi 1827387616 3029 GRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd17633    293 QKLSRYEIPKKIIFVDSLPYTSSGKIAR 320

ttLC_FACS_AEE21_like

cd12118

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...

4-468

9.36e-18

Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 89.67 E-value: 9.36e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:cd12118     33 RQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLDAEEIAFILRHSEAKVLFVDREFE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEArsrfddivdvhVLDISSPGdadldeeefAGPTRPANA--AFTL-FTSGSTGRPKAVVITHRGIA-NRLAADIEqYDL 159
Cdd:cd12118    113 YED-----------LLAEGDPD---------FEWIPPADEwdPIALnYTSGTTGRPKGVVYHHRGAYlNALANILE-WEM 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARDVFLYKAPI------TFdvsvreIFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTviHF-----VPAMLAAFNE 228
Cdd:cd12118    172 KQHPVYLWTLPMfhcngwCF------PWTVAAVGGTNVCL---RKVDAKAIYDLIEKHKVT--HFcgaptVLNMLANAPP 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  229 vlgAGVGELTSLRLIQTGGeALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTI-------HRVTQDDRVipigtptrRV 301
Cdd:cd12118    241 ---SDARPLPHRVHVMTAG-APPPAAVLAKMEEL-GFDVTHVYGLTETYGPATVcawkpewDELPTEERA--------RL 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  302 SAR------------VLDAalrEVPIGVP------GELYLGGVQLARGYAGRPDLTAERFvadpfgEPGarLYRTGDRAR 363
Cdd:cd12118    308 KARqgvryvgleevdVLDP---ETMKPVPrdgktiGEIVFRGNIVMKGYLKNPEATAEAF------RGG--WFHSGDLAV 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  364 WNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLhaAAAVVDGPG---GQQLVGYLA---PADVDVDTVAATTA 437
Cdd:cd12118    377 IHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVL--EAAVVARPDekwGEVPCAFVElkeGAKVTEEEIIAFCR 454

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1827387616  438 ELLPEYMRPSAWVRLDaMPLSRSGKVDRRLL 468
Cdd:cd12118    455 EHLAGFMVPKTVVFGE-LPKTSTGKIQKFVL 484

PLN02574

4-coumarate--CoA ligase-like

1050-1530

1.07e-17

4-coumarate--CoA ligase-like

Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 89.90 E-value: 1.07e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALI--CDGTEMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIA 1126
Cdd:PLN02574    53 NGDTALIdsSTGFSISYSELQPLVKSMAAGLYHVmGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIK 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1127 YMLEDSGATVGITDASTRARLGE------SSCEWVDLADLEAEAESGDDI----TDTERNGSVRLTNLAYLIYTSGSTGR 1196
Cdd:PLN02574   133 KRVVDCSVGLAFTSPENVEKLSPlgvpviGVPENYDFDSKRIEFPKFYELikedFDFVPKPVIKQDDVAAIMYSSGTTGA 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1197 PKAVGVSHTGIVDFVNSLAKITTGTPEDEPDTRILHVASPSFDA---SMFEMAwAIPAGHTLVIAPQADfAGDALaTVLE 1273
Cdd:PLN02574   213 SKGVVLTHRNLIAMVELFVRFEASQYEYPGSDNVYLAALPMFHIyglSLFVVG-LLSLGSTIVVMRRFD-ASDMV-KVID 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1274 RDEVTDMIITPSVLA----TVDPERAQYVRNL---ATGGEACPPELVERWSERGRRI--FNCYGPTEATVWATRSRMTA- 1343
Cdd:PLN02574   290 RFKVTHFPVVPPILMaltkKAKGVCGEVLKSLkqvSCGAAPLSGKFIQDFVQTLPHVdfIQGYGMTESTAVGTRGFNTEk 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1344 -GKPVTIGKPVDGFTVRVLD---GRLheVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRV 1419
Cdd:PLN02574   370 lSKYSSVGLLAPNMQAKVVDwstGCL--LPPGNCGELWIQGPGVMKGYLNNPKATQSTIDKDGW-------LRTGDIAYF 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1420 AKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEA 1498
Cdd:PLN02574   441 DEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECG----EIpVAFVVRRQGSTLSQEAVINYV 516

                          490       500       510
                   ....*....|....*....|....*....|..
gi 1827387616 1499 AQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PLN02574   517 AKQVAPYKKVRKVVFVQSIPKSPAGKILRREL 548

FACL_like_1

cd05910

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

2590-3000

1.22e-17

Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 88.67 E-value: 1.22e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2590 ARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDsgavlgls 2669
Cdd:cd05910      1 SRLSFRELDERSDRIAQGLTAYGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQE-------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2670 vlasgdlpgqefewmrldddsvaaeiaAVPAGPItdaerlGEVTAANLAYVIYTSGSTGRPKGVAVTHSglaNFARQ--- 2746
Cdd:cd05910     73 ---------------------------AEPDAFI------GIPKADEPAAILFTSGSTGTPKGVVYRHG---TFAAQida 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2747 --------ESDRLNAGDNPV-----VLGFAS--PSFDASvleyllatvnegtlayRPSEAVGGEVLErFIAEHGATHTFL 2811
Cdd:cd05910    117 lrqlygirPGEVDLATFPLFalfgpALGLTSviPDMDPT----------------RPARADPQKLVG-AIRQYGVSIVFG 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2812 TPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVDRW----APATELHNLYGPTE----TTIG-----ITISSAMRP 2872
Cdd:cd05910    180 SPALLERVarycaqHGITLPSLRRVLSAGAPVPIALAARLrkmlSDEAEILTPYGATEalpvSSIGsrellATTTAATSG 259

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2873 GDPVRLGGPIGGVDLMVL----------DERLRpVPVGMPGELYVAGGALSRGYLDRSGLTAerfTANPYGTAGQRMYRT 2942
Cdd:cd05910    260 GAGTCVGRPIPGVRVRIIeiddepiaewDDTLE-LPRGEIGEITVTGPTVTPTYVNRPVATA---LAKIDDNSEGFWHRM 335

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 2943 GDVVRWtpdtDTGGlTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG 3000
Cdd:cd05910    336 GDLGYL----DDEG-RLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGVG 388

PtmA

cd17636

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...

127-464

1.58e-17

Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 86.59 E-value: 1.58e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  127 LFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPItFDVSVREIFLPI-AIGATLVIAepgRHGDPVHLA 205
Cdd:cd17636      6 IYTAAFSGRPNGALLSHQALLAQALVLAVLQAIDEGTVFLNSGPL-FHIGTLMFTLATfHAGGTNVFV---RRVDAEEVL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 DLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGE------ALTPPVARDLMvrlpgtrlqnQYGPAEASIV 279
Cdd:cd17636     82 ELIEAERCTHAFLLPPTIDQIVELNADGLYDLSSLRSSPAAPEwndmatVDTSPWGRKPG----------GYGQTEVMGL 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  280 VTIHRVTQDDRVIpIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVadpfgepgARLYRTG 359
Cdd:cd17636    152 ATFAALGGGAIGG-AGRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTR--------GGWHHTN 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  360 DRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGYLApadVDVDTVAATTAEL 439
Cdd:cd17636    223 DLGRREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKAIV---VLKPGASVTEAEL 299

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1827387616  440 -------LPEYMRPSAWVRLDAMPLSRSGKVD 464
Cdd:cd17636    300 iehcrarIASYKKPKSVEFADALPRTAGGADD 331

PRK09274

peptide synthase; Provisional

2561-3027

1.76e-17

peptide synthase; Provisional

Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 89.19 E-value: 1.76e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2561 ATDPVTLAELFRAAARRAPDHVAVVDGAG---------ARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLT 2631
Cdd:PRK09274     2 MASMANIARHLPRAAQERPDQLAVAVPGGrgadgklayDELSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2632 AIWAVAKTGGAYVPIDPDYPAERVASMIEDSG--AVLG--LSVLASgdlpgqefEWMRLDDDSV-------------AAE 2694
Cdd:PRK09274    82 LTFALFKAGAVPVLVDPGMGIKNLKQCLAEAQpdAFIGipKAHLAR--------RLFGWGKPSVrrlvtvggrllwgGTT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2695 IAAVPAGPITDAERLGEVTAANLAYVIYTSGSTGRPKGVAVTHSglaNFARQ-----ESDRLNAGD------------NP 2757
Cdd:PRK09274   154 LATLLRDGAAAPFPMADLAPDDMAAILFTSGSTGTPKGVVYTHG---MFEAQiealrEDYGIEPGEidlptfplfalfGP 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2758 VvLGFAS--PSFDASvleyllatvnegtlayRPSeAVGGEVLERFIAEHGATHTFLTPSVLSTM------DPTAVPSLRV 2829
Cdd:PRK09274   231 A-LGMTSviPDMDPT----------------RPA-TVDPAKLFAAIERYGVTNLFGSPALLERLgrygeaNGIKLPSLRR 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2830 IAAGGEAVPQPIVDRW----APATELHNLYGPTE----TTIG-----ITISSAMRPGDPVRLGGPIGGVDLMVLD----- 2891
Cdd:PRK09274   293 VISAGAPVPIAVIERFramlPPDAEILTPYGATEalpiSSIEsreilFATRAATDNGAGICVGRPVDGVEVRIIAisdap 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2892 ----ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMyrtGDVVRWtpdtDTGGLtLEYTGRSDD 2967
Cdd:PRK09274   373 ipewDDALRLATGEIGEIVVAGPMVTRSYYNRPEATRLAKIPDGQGDVWHRM---GDLGYL----DAQGR-LWFCGRKAH 444

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2968 QVKLRGLRIELGEIEAVLAEHDAV-ESAVVL-GVGGSVATAL----AAYIVPVDGAVEvSELKAFA 3027
Cdd:PRK09274   445 RVETAGGTLYTIPCERIFNTHPGVkRSALVGvGVPGAQRPVLcvelEPGVACSKSALY-QELRALA 509

PRK07008

long-chain-fatty-acid--CoA ligase; Validated

2564-3061

1.79e-17

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 89.00 E-value: 1.79e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAV---VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTG 2640
Cdd:PRK07008     9 PLLISSLIAHAARHAGDTEIVsrrVEGDIHRYTYRDCERRAKQLAQALAALGVEPGDRVGTLAWNGYRHLEAYYGVSGSG 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2641 GAYVPIDPDYPAERVASMI---EDSGAVLGLSVLA-----SGDLPGQEfEWMRLDDDsvaaeiAAVPAGPI--------T 2704
Cdd:PRK07008    89 AVCHTINPRLFPEQIAYIVnhaEDRYVLFDLTFLPlvdalAPQCPNVK-GWVAMTDA------AHLPAGSTpllcyetlV 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2705 DAE-------RLGEVTAANLAYviyTSGSTGRPKGVAVTH--SGLANFARQESD--RLNAGDN--PVVlgfasPSF--DA 2769
Cdd:PRK07008   162 GAQdgdydwpRFDENQASSLCY---TSGTTGNPKGALYSHrsTVLHAYGAALPDamGLSARDAvlPVV-----PMFhvNA 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2770 SVLEYLLATVneGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSV----LSTMDPTAV--PSLRVIAAGGEAVPQPIVD 2843
Cdd:PRK07008   234 WGLPYSAPLT--GAKLVLPGPDLDGKSLYELIEAERVTFSAGVPTVwlglLNHMREAGLrfSTLRRTVIGGSACPPAMIR 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2844 RWAPA--TELHNLYGPTE-----TTIGITISSAMRPGDPVR-----LGGPIGGVDLMVLDERLRPVPV-GMP-GELYVAG 2909
Cdd:PRK07008   312 TFEDEygVEVIHAWGMTEmsplgTLCKLKWKHSQLPLDEQRkllekQGRVIYGVDMKIVGDDGRELPWdGKAfGDLQVRG 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2910 GALSRGYL--DRSGLTAERFTanpygtagqrmyrTGDVVrwTPDTDTgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAE 2987
Cdd:PRK07008   392 PWVIDRYFrgDASPLVDGWFP-------------TGDVA--TIDADG---FMQITDRSKDVIKSGGEWISSIDIENVAVA 453

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2988 HDAVESAVVLGVGGSVATALAAYIVPVDGAVEVS--ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK07008   454 HPAVAEAACIACAHPKWDERPLLVVVKRPGAEVTreELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLRE 529

LC_FACL_like

cd05914

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...

1059-1527

2.20e-17

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 88.27 E-value: 2.20e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1059 GTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGI 1138
Cdd:cd05914      5 GEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAIF 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1139 TdastrarlgesscewvdladleaeaesgddiTDTErngsvrltNLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKIT 1218
Cdd:cd05914     85 V-------------------------------SDED--------DVALINYTSGTTGNSKGVMLTYRNIVSNVDGVKEVV 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1219 TGTPEDepdtRILhvaspsfdaSMFEMAWAIPAGHTLVIAPQAD----FAGD---ALATVLERDEVTDMIITPSVLATVD 1291
Cdd:cd05914    126 LLGKGD----KIL---------SILPLHHIYPLTFTLLLPLLNGahvvFLDKipsAKIIALAFAQVTPTLGVPVPLVIEK 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1292 ---------------------PERAQYVRNLA----------------TGGEACPPELVERWSERGRRIFNCYGPTEATV 1334
Cdd:cd05914    193 ifkmdiipkltlkkfkfklakKINNRKIRKLAfkkvheafggnikefvIGGAKINPDVEEFLRTIGFPYTIGYGMTETAP 272

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 WATRSRMTAGKPVTIGKPVDGFTVRVLDgrlhEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATG 1414
Cdd:cd05914    273 IISYSPPNRIRLGSAGKVIDGVEVRIDS----PDPATGEGEIIVRGPNVMKGYYKNPEATAEAFDKDGW-------FHTG 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQ-VKINGQRVELGEIEAVLDAQPGVAQSVVVgvestrggRKHTEVVAYLVAKPGATIDSA- 1492
Cdd:cd05914    342 DLGKIDAEGYLYIRGRKKEMiVLSSGKNIYPEEIEAKINNMPFVLESLVV--------VQEKKLVALAYIDPDFLDVKAl 413

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616 1493 -----------AVLDEAAQHLAAH-MVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd05914    414 kqrniidaikwEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKR 460

PRK12582

acyl-CoA synthetase; Provisional

2564-3008

2.44e-17

acyl-CoA synthetase; Provisional

Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 88.95 E-value: 2.44e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAVV-----DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAK 2638
Cdd:PRK12582    48 PRSIPHLLAKWAAEAPDRPWLAqrepgHGQWRKVTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEHALMTLAAMQ 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2639 TGGAYVPIDPDYpaervaSMIEDSGAVL---------GLSVLASGDLPGQEFEWMRLDDDSV-----------AAEIAAV 2698
Cdd:PRK12582   128 AGVPAAPVSPAY------SLMSHDHAKLkhlfdlvkpRVVFAQSGAPFARALAALDLLDVTVvhvtgpgegiaSIAFADL 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2699 PAGPITD--AERLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGL-ANFARQESDRLNAGDNPVvlgfaspsfdASVLEYL 2775
Cdd:PRK12582   202 AATPPTAavAAAIAAITPDTVAKYLFTSGSTGMPKAVINTQRMMcANIAMQEQLRPREPDPPP----------PVSLDWM 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2776 -------------LATVNEGTLAYRPSEAVGGEVLE--RFIAEHGATHTFLTPSVLSTM------DPTAVPS----LRVI 2830
Cdd:PRK12582   272 pwnhtmggnanfnGLLWGGGTLYIDDGKPLPGMFEEtiRNLREISPTVYGNVPAGYAMLaeamekDDALRRSffknLRLM 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2831 AAGGEAVPQPIVDRW---APATELHNL-----YGPTETTiGITISSAMRPGDPVRLGGPIGGVDLMVlderlrpVPVGMP 2902
Cdd:PRK12582   352 AYGGATLSDDLYERMqalAVRTTGHRIpfytgYGATETA-PTTTGTHWDTERVGLIGLPLPGVELKL-------APVGDK 423

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2903 GELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTpDTDTGGLTLEYTGRSDDQVKL-RGLRIELGE- 2980
Cdd:PRK12582   424 YEVRVKGPNVTPGYHKDPELTAAAFDEEGF-------YRLGDAARFV-DPDDPEKGLIFDGRVAEDFKLsTGTWVSVGTl 495

                          490       500
                   ....*....|....*....|....*....
gi 1827387616 2981 -IEAVLAEHDAVESAVVLGVGGSVATALA 3008
Cdd:PRK12582   496 rPDAVAACSPVIHDAVVAGQDRAFIGLLA 524

ACLS-CaiC

cd17637

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...

127-465

2.47e-17

Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 86.17 E-value: 2.47e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  127 LFTSGSTGRPKAVVITHRGIanrLAADIE---QYDLTARDVFLYKAPItFDVSvrEIFLPIAI---GATLVIAEpgrHGD 200
Cdd:cd17637      6 IHTAAVAGRPRGAVLSHGNL---IAANLQlihAMGLTEADVYLNMLPL-FHIA--GLNLALATfhaGGANVVME---KFD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  201 PVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIqTGGEalTPPVARDLMVRLPGTrLQNQYGPAEASIVV 280
Cdd:cd17637     77 PAEALELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSLRHV-LGLD--APETIQRFEETTGAT-FWSLYGQTETSGLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  281 TIHRVtqDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGD 360
Cdd:cd17637    153 TLSPY--RERPGSAGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNG--------WHHTGD 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  361 RARWNRDGEIEYLGRTDFQ--VKLRGQRLELGEVEAALAAAPGVlhaAAAVVDG-PG-----GQQLVGYLAP-ADVDVDT 431
Cdd:cd17637    223 LGRFDEDGYLWYAGRKPEKelIKPGGENVYPAEVEKVILEHPAI---AEVCVIGvPDpkwgeGIKAVCVLKPgATLTADE 299

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1827387616  432 VAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDR 465
Cdd:cd17637    300 LIEFVGSRIARYKKPRYVVFVEALPKTADGSIDR 333

PrpE

cd05967

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...

2581-3074

3.91e-17

Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 88.14 E-value: 3.91e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2581 HVAVVDGAGARLTYRELDEASDRLARWLIGRGVG------------PERAVA-LAIGRsaqlLTAIWAVAKTGGAyvpid 2647
Cdd:cd05967     72 YDSPVTGTERTYTYAELLDEVSRLAGVLRKLGVVkgdrviiympmiPEAAIAmLACAR----IGAIHSVVFGGFA----- 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2648 pdypAERVASMIEDSGAVLGLSvlASGDL-PGQEFEWMRLDDDSVA--------------AEIAAVPAGPITD------- 2705
Cdd:cd05967    143 ----AKELASRIDDAKPKLIVT--ASCGIePGKVVPYKPLLDKALElsghkphhvlvlnrPQVPADLTKPGRDldwsell 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2706 --AERLGEVT--AANLAYVIYTSGSTGRPKGVAVTHSGLA---NFARQESDRLNAGDnpvVLGFASP-------SFdaSV 2771
Cdd:cd05967    217 akAEPVDCVPvaATDPLYILYTSGTTGKPKGVVRDNGGHAvalNWSMRNIYGIKPGD---VWWAASDvgwvvghSY--IV 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2772 LEYLLATVNegTLAY--RPSEAVGGEVLERFIAEHGATHTFLTPS---VLSTMDPTA-------VPSLRVIAAGGE---- 2835
Cdd:cd05967    292 YGPLLHGAT--TVLYegKPVGTPDPGAFWRVIEKYQVNALFTAPTairAIRKEDPDGkyikkydLSSLRTLFLAGErldp 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2836 --------AVPQPIVDRWapatelhnlyGPTETTIGITISS------AMRPGDPvrlGGPIGGVDLMVLDERLRPVPVGM 2901
Cdd:cd05967    370 ptlewaenTLGVPVIDHW----------WQTETGWPITANPvgleplPIKAGSP---GKPVPGYQVQVLDEDGEPVGPNE 436

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2902 PGELYVAG----GALSRGYLDRsgltaERFTaNPYGTAGQRMYRTGDvvrWTPDTDTGGLTLeyTGRSDDQVKLRGLRIE 2977
Cdd:cd05967    437 LGNIVIKLplppGCLLTLWKND-----ERFK-KLYLSKFPGYYDTGD---AGYKDEDGYLFI--MGRTDDVINVAGHRLS 505

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2978 LGEIEAVLAEHDAVESAVVLGV----GGSVATALAayiVPVDGAVEV-----SELKAFAGGRLPAYMVPSSFTVIDELPL 3048
Cdd:cd05967    506 TGEMEESVLSHPAVAECAVVGVrdelKGQVPLGLV---VLKEGVKITaeeleKELVALVREQIGPVAAFRLVIFVKRLPK 582

                          570       580
                   ....*....|....*....|....*.
gi 1827387616 3049 TPVGKLDKRALPEpVLEAGEYVAPAT 3074
Cdd:cd05967    583 TRSGKILRRTLRK-IADGEDYTIPST 607

PRK08276

long-chain-fatty-acid--CoA ligase; Validated

4-471

3.99e-17

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 87.65 E-value: 3.99e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:PRK08276    15 GELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDSGAKVLIVSAALA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDI----VDVHVLDISSPGDADLDEEEFAGPTRP----ANAAFTLFTSGSTGRPKAVV--ITHRGI----ANR 149
Cdd:PRK08276    95 DTAAELAAELpagvPLLLVVAGPVPGFRSYEEALAAQPDTPiadeTAGADMLYSSGTTGRPKGIKrpLPGLDPdeapGMM 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  150 LAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEpgrHGDPVHLADLIRRHGVTVIHFVPAM----LAA 225
Cdd:PRK08276   175 LALLGFGMYGGPDSVYLSPAPLYHTAPLRFGMSALALGGTVVVME---KFDAEEALALIERYRVTHSQLVPTMfvrmLKL 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  226 FNEVLGAgvGELTSLRLIQTGGEALTPPVARDlMVRLPGTRLQNQYGPAEASIVVTIhrvTQDDRVIPIGTPTRRVSA-- 303
Cdd:PRK08276   252 PEEVRAR--YDVSSLRVAIHAAAPCPVEVKRA-MIDWWGPIIHEYYASSEGGGVTVI---TSEDWLAHPGSVGKAVLGev 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  304 RVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVadpfgepGARLYRTGDRARWNRDGeieYLGRTD---FQV 380
Cdd:PRK08276   326 RILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAARN-------PHGWVTVGDVGYLDEDG---YLYLTDrksDMI 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  381 KLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADvDVDTVAATTAEL-------LPEYMRPSAWVRL 452
Cdd:PRK08276   396 ISGGVNIYPQEIENLLVTHPKVADVAVfGVPDEEMGERVKAVVQPAD-GADAGDALAAELiawlrgrLAHYKCPRSIDFE 474

                          490
                   ....*....|....*....
gi 1827387616  453 DAMPLSRSGKVDRRLLPEP 471
Cdd:PRK08276   475 DELPRTPTGKLYKRRLRDR 493

PLN02860

o-succinylbenzoate-CoA ligase

2-413

4.27e-17

o-succinylbenzoate-CoA ligase

Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 87.93 E-value: 4.27e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTagVRLVVVTSD 81
Cdd:PLN02860    34 TGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSFEEAKSAMLL--VRPVMLVTD 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 GEAEA---RSRFDDI--VDVHVL-----DISSPGDAD-----------LDEEEFAGPTRPANAAFTLFTSGSTGRPKAVV 140
Cdd:PLN02860   112 ETCSSwyeELQNDRLpsLMWQVFlespsSSVFIFLNSflttemlkqraLGTTELDYAWAPDDAVLICFTSGTTGRPKGVT 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  141 ITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAePGRHGDPVhlADLIRRHGVTVIHFVP 220
Cdd:PLN02860   192 ISHSALIVQSLAKIAIVGYGEDDVYLHTAPLCHIGGLSSALAMLMVGACHVLL-PKFDAKAA--LQAIKQHNVTSMITVP 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  221 AMLAAFNEV--LGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEA--SIV-VTIHRVTQDDRVIPIG 295
Cdd:PLN02860   269 AMMADLISLtrKSMTWKVFPSVRKILNGGGSLSSRLLPDAKKLFPNAKLFSAYGMTEAcsSLTfMTLHDPTLESPKQTLQ 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  296 TPTRRVSARV---------LDAALREVPIGVPGELYLGGVqLARG------YAGRPDLTAERFVADPFGEpgarlyrTGD 360
Cdd:PLN02860   349 TVNQTKSSSVhqpqgvcvgKPAPHVELKIGLDESSRVGRI-LTRGphvmlgYWGQNSETASVLSNDGWLD-------TGD 420

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  361 RARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGP 413
Cdd:PLN02860   421 IGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGV--ASVVVVGVP 471

PRK06334

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

2716-3001

4.30e-17

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 87.95 E-value: 4.30e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLanFARQES--DRLNAGDNPVVLGFASP----SFDASVLEYLLATVNEgTLAYRPS 2789
Cdd:PRK06334   184 DVAVILFTSGTEKLPKGVPLTHANL--LANQRAclKFFSPKEDDVMMSFLPPfhayGFNSCTLFPLLSGVPV-VFAYNPL 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2790 EAvggEVLERFIAEHGATHTFLTPSVLSTMDPTA------VPSLRVIAAGGEAVPQPI---VDRWAPATELHNLYGPTET 2860
Cdd:PRK06334   261 YP---KKIVEMIDEAKVTFLGSTPVFFDYILKTAkkqescLPSLRFVVIGGDAFKDSLyqeALKTFPHIQLRQGYGTTEC 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2861 TIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLR-PVPVGMPGELYVAGGALSRGYLdrsgltAERFTANPYGTAGQRM 2939
Cdd:PRK06334   338 SPVITINTVNSPKHESCVGMPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYL------GEDFGQGFVELGGETW 411

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 2940 YRTGDVVRWTPDtdtGGLTLEytGRSDDQVKLRGLRIELGEIEAVLAEH------DAVESAVVLGVGG 3001
Cdd:PRK06334   412 YVTGDLGYVDRH---GELFLK--GRLSRFVKIGAEMVSLEALESILMEGfgqnaaDHAGPLVVCGLPG 474

FadD3

cd17638

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...

2716-3056

6.75e-17

Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 84.86 E-value: 6.75e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLANFARQESD--RLNAGDNPVVLG--FASPSFDASVLEYLL--ATVNEGTLaYRPS 2789
Cdd:cd17638      1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADcaDLTEDDRYLIINpfFHTFGYKAGIVACLLtgATVVPVAV-FDVD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2790 EAVGGEVLERFIAEHGATHTFLTPSVLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNL---YGPTETTIGiTI 2866
Cdd:cd17638     80 AILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMRSELGFETVltaYGLTEAGVA-TM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2867 SsamRPGDPVRL-----GGPIGGVDLMVLDerlrpvpvgmPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYR 2941
Cdd:cd17638    159 C---RPGDDAETvattcGRACPGFEVRIAD----------DGEVLVRGYNVMQGYLDDPEATAEAIDADGW-------LH 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2942 TGDVVRWtpdTDTGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG----GSVATalaAYIVPVDG- 3016
Cdd:cd17638    219 TGDVGEL---DERGYLRI--TDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPdermGEVGK---AFVVARPGv 290

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1827387616 3017 AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd17638    291 TLTEEDVIAWCRERLANYKVPRFVRFLDELPRNASGKVMK 330

AcpA

COG3433

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...

275-554

7.06e-17

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442659 [Multi-domain] Cd Length: 295 Bit Score: 84.03 E-value: 7.06e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  275 EASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFGEPGAR 354
Cdd:COG3433      1 IAIATPPPAPPTPDEPPPVIPPAIVQARALLLIVDLQGYFGGFGGEGGLLGAGLLLRIRLLAAAARAPFIPVPYPAQPGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  355 LYRTGDRARWNRDGEIEYL--GRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVDTV 432
Cdd:COG3433     81 QADDLRLLLRRGLGPGGGLerLVQQVVIRAERGEEEELLLVLRAAAVVRVAVLAALRGAGVGLLLIVGAVAALDGLAAAA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  433 AATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEIAPTL--YVPPGNADE-----ETVAGLFAELLGV--ERVG 503
Cdd:COG3433    161 ALAALDKVPPDVVAASAVVALDALLLLALKVVARAAPALAAAEALlaAASPAPALEtalteEELRADVAELLGVdpEEID 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616  504 VTDSFFDIGGSSLSAARIAARVsKELGVDVSVRDVFESPSVRGLVHAVSGR 554
Cdd:COG3433    241 PDDNLFDLGLDSIRLMQLVERW-RKAGLDVSFADLAEHPTLAAWWALLAAA 290

entE

PRK10946

(2,3-dihydroxybenzoyl)adenylate synthase;

2564-3059

7.54e-17

(2,3-dihydroxybenzoyl)adenylate synthase;

Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 86.97 E-value: 7.54e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRA-------------AARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLL 2630
Cdd:PRK10946     9 PEEFARRYREkgywqdlpltdilTRHAASDAIAVICG-ERQFSYRELNQASDNLACSLRRQGIKPGDTALVQLGNVAEFY 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2631 TAIWAVAKTGgaYVPIDPDY---------------PAERVAS----------MIEDSGAVLG--LSVLASGDLPGQEFew 2683
Cdd:PRK10946    88 ITFFALLKLG--VAPVNALFshqrselnayasqiePALLIADrqhalfsdddFLNTLVAEHSslRVVLLLNDDGEHSL-- 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2684 mrldDDSVAAEIAAVPAGPiTDAerlGEVtaanlAYVIYTSGSTGRPKGVAVTHSGLANFARQESD--RLNAGDN----- 2756
Cdd:PRK10946   164 ----DDAINHPAEDFTATP-SPA---DEV-----AFFQLSGGSTGTPKLIPRTHNDYYYSVRRSVEicGFTPQTRylcal 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2757 PVVLGFASPSFDASVLEYLLATVnegTLAYRPSEAVGGEVLERfiaeHGATHTFLTPSVLS-----TMDPT---AVPSLR 2828
Cdd:PRK10946   231 PAAHNYPMSSPGALGVFLAGGTV---VLAPDPSATLCFPLIEK----HQVNVTALVPPAVSlwlqaIAEGGsraQLASLK 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2829 VIAAGGEAVPQPIVDRwAPAT---ELHNLYGPTE----------------TTIGITISsamrPGDPVRlggpiggvdlmV 2889
Cdd:PRK10946   304 LLQVGGARLSETLARR-IPAElgcQLQQVFGMAEglvnytrlddsderifTTQGRPMS----PDDEVW-----------V 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2890 LDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTLEytGRSDDQV 2969
Cdd:PRK10946   368 ADADGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF-------YCSGDLVSIDPD---GYITVV--GREKDQI 435

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2970 KLRGLRIELGEIEAVLAEHDAV-ESAVVlgvggSVATAL-----AAYIVPVDgAVEVSELKAFAGGRLPA-YMVPSSFTV 3042
Cdd:PRK10946   436 NRGGEKIAAEEIENLLLRHPAViHAALV-----SMEDELmgeksCAFLVVKE-PLKAVQLRRFLREQGIAeFKLPDRVEC 509

                          570
                   ....*....|....*..
gi 1827387616 3043 IDELPLTPVGKLDKRAL 3059
Cdd:PRK10946   510 VDSLPLTAVGKVDKKQL 526

PRK08751

long-chain fatty acid--CoA ligase;

1051-1536

1.28e-16

long-chain fatty acid--CoA ligase;

Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 86.47 E-value: 1.28e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1051 DHPALICDGTEMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PRK08751    40 DRPAYHSFGKTITYREADQLVEQFAAYLLGElQLKKGDRVALMMPNCLQYPIATFGVLRAGLTVVNVNPLYTPRELKHQL 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATV-------GITDASTRARLGESSCEWVDLADLEAEAESG----------DDITDTERNGSVRLT---------- 1182
Cdd:PRK08751   120 IDSGASVlvvidnfGTTVQQVIADTPVKQVITTGLGDMLGFPKAAlvnfvvkyvkKLVPEYRINGAIRFRealalgrkhs 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 ---------NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDEPDTRILHVASPS---FDASMFEMAWAIP 1250
Cdd:PRK08751   200 mptlqiepdDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHQWLAGTGKLEEGCEVVITALPLyhiFALTANGLVFMKI 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1251 AGHTLVIAPQADFAGdaLATVLERDEVT----------DMIITPSvLATVDperAQYVRNLATGGEACPPELVERWSE-R 1319
Cdd:PRK08751   280 GGCNHLISNPRDMPG--FVKELKKTRFTaftgvntlfnGLLNTPG-FDQID---FSSLKMTLGGGMAVQRSVAERWKQvT 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1320 GRRIFNCYGPTEATVWATRSRMTAGK-PVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSF 1398
Cdd:PRK08751   354 GLTLVEAYGLTETSPAACINPLTLKEyNGSIGLPIPSTDACIKDDAGTVLAIGEIGELCIKGPQVMKGYWKRPEETAKVM 433

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1399 VADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEVV 1478
Cdd:PRK08751   434 DADGW-------LHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLEVAAVGVPDEKSG----EIV 502

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1479 AYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPEPHAP 1536
Cdd:PRK08751   503 KVVIVKKDPALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRDAAKA 560

ACS

cd05966

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...

125-468

1.39e-16

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.

Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 86.46 E-value: 1.39e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  125 FTLFTSGSTGRPKAVVITHRGianrlaadieqYDLTARDVFLYkapiTFDVSVREIFL-----------------PIAIG 187
Cdd:cd05966    235 FILYTSGSTGKPKGVVHTTGG-----------YLLYAATTFKY----VFDYHPDDIYWctadigwitghsyivygPLANG 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  188 ATLVIAE-------PGRHgdpvhlADLIRRHGVTVIHFVPAMLAAFnevLGAGVG-----ELTSLRLIQTGGEALTPPVA 255
Cdd:cd05966    300 ATTVMFEgtptypdPGRY------WDIVEKHKVTIFYTAPTAIRAL---MKFGDEwvkkhDLSSLRVLGSVGEPINPEAW 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  256 RdlmvrlpgtRLQNQYGPAEASIVVTI-------HRVTQddrvIPIGTPTRR---------VSARVLDAALREVPIGVPG 319
Cdd:cd05966    371 M---------WYYEVIGKERCPIVDTWwqtetggIMITP----LPGATPLKPgsatrpffgIEPAILDEEGNEVEGEVEG 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  320 EL-----YLGgvqLARGYAGRPdltaERFVADPFGE-PGarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVE 393
Cdd:cd05966    438 YLvikrpWPG---MARTIYGDH----ERYEDTYFSKfPG--YYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVE 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  394 AALAAAPGVlhAAAAVVDGP---GGQQLVGYL------APADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVD 464
Cdd:cd05966    509 SALVAHPAV--AEAAVVGRPhdiKGEAIYAFVtlkdgeEPSDELRKELRKHVRKEIGPIATPDKIQFVPGLPKTRSGKIM 586


                   ....
gi 1827387616  465 RRLL 468
Cdd:cd05966    587 RRIL 590

PRK07867

acyl-CoA synthetase; Validated

2561-3059

1.96e-16

acyl-CoA synthetase; Validated

Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 85.50 E-value: 1.96e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2561 ATDPVTLAELFRAaarRAPDHVAVVDGAGARLTYRELDEASDRLARWLIGR-GVGPERAVALAIGRSAQLLTAIWAVAKT 2639
Cdd:PRK07867     1 TSSAPTVAELLLP---LAEDDDRGLYFEDSFTSWREHIRGSAARAAALRARlDPTRPPHVGVLLDNTPEFSLLLGAAALS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2640 GGAYVPIDPDYPAERVASMIE--DSGAVL---GLSVLASGDLPGQEFewmrLDDDSVA-AEIAAVPAGPITDAerlGEVT 2713
Cdd:PRK07867    78 GIVPVGLNPTRRGAALARDIAhaDCQLVLtesAHAELLDGLDPGVRV----INVDSPAwADELAAHRDAEPPF---RVAD 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2714 AANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLgFASPSF--DASVLEYLLATVNEGTLAYRPSEA 2791
Cdd:PRK07867   151 PDDLFMLIFTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDDVCY-VSMPLFhsNAVMAGWAVALAAGASIALRRKFS 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 VGGevlerFIA---EHGATHTFLTPSVLSTMDPT------AVPSLRvIAAGGEAVPqPIVDRWAP--ATELHNLYGPTET 2860
Cdd:PRK07867   230 ASG-----FLPdvrRYGATYANYVGKPLSYVLATperpddADNPLR-IVYGNEGAP-GDIARFARrfGCVVVDGFGSTEG 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2861 TIGITISSAMRPGDpvrLGGPIGGVDlmVLD-ERLRPVPVGMP------------GELY-VAGGALSRGYLDRSGLTAER 2926
Cdd:PRK07867   303 GVAITRTPDTPPGA---LGPLPPGVA--IVDpDTGTECPPAEDadgrllnadeaiGELVnTAGPGGFEGYYNDPEADAER 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2927 FTANpygtagqrMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVA-T 3005
Cdd:PRK07867   378 MRGG--------VYWSGDLAY----RDADGY-AYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVgD 444

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 3006 ALAAYIVPVDGAV-EVSELKAFAGGR--LPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK07867   445 QVMAALVLAPGAKfDPDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQL 501

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

1670-1870

2.07e-16

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 81.62 E-value: 2.07e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1670 VADLQTVVEAVAAAHPMLTAVLTRSGDGWTMNAGAGIVPAVREIDAEGALDPALVDAHRELLGA-----MDPGTGSLLGT 1744
Cdd:COG4908     32 VEALERALRELVRRHPALRTRFVEEDGEPVQRIDPDADLPLEVVDLSALPEPEREAELEELVAEeasrpFDLARGPLLRA 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1745 AVVNGEGRR-RLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEATTTRRIAHLLAG--QVHARAREVDYWLE 1821
Cdd:COG4908    112 ALIRLGEDEhVLLLTIHHIISDGWSLGILLRELAALYAALLEGEPPPLPELPIQYADYAAWQRAwlQSEALEKQLEYWRQ 191

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1822 QL--PERPTSFGTSADRPLHRRRDESSLTYVVDDVAGSILTTVPQAFGSSV 1870
Cdd:COG4908    192 QLagAPPVLELPTDRPRPAVQTFRGATLSFTLPAELTEALKALAKAHGATV 242

FADD10

cd17635

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...

2720-3056

2.63e-16

Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 83.08 E-value: 2.63e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHSGLanFARQE---SDRLNAGDNPVVLGFASPSFDASVLeYLLATVNEGTLAYRPSEAVGGEV 2796
Cdd:cd17635      6 VIFTSGTTGEPKAVLLANKTF--FAVPDilqKEGLNWVVGDVTYLPLPATHIGGLW-WILTCLIHGGLCVTGGENTTYKS 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2797 LERFIAEHGATHTFLTPSVLS-----TMDPTA-VPSLRVIAAGGEavpQPIVDR-----WAPATELHNLYGPTETTIGIT 2865
Cdd:cd17635     83 LFKILTTNAVTTTCLVPTLLSklvseLKSANAtVPSLRLIGYGGS---RAIAADvrfieATGLTNTAQVYGLSETGTALC 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2866 ISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTanpygtagQRMYRTGDV 2945
Cdd:cd17635    160 LPTDDDSIEINAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLI--------DGWVNTGDL 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2946 VRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATAL-AAYIV--PVDGAVEVSE 3022
Cdd:cd17635    232 GE----RREDGF-LFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELvGLAVVasAELDENAIRA 306

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1827387616 3023 LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:cd17635    307 LKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340

BACL_like

cd05929

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...

103-468

2.73e-16

Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 84.74 E-value: 2.73e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  103 SPGDADLDEEEFAGPTRP----ANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDL---TARDVFLYKAPITFDV 175
Cdd:cd05929    103 LDGLEDYEAAEGGSPETPiedeAAGWKMLYSGGTTGRPKGIKRGLPGGPPDNDTLMAAALGfgpGADSVYLSPAPLYHAA 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  176 SVREIFLPIAIGATLVIAEpgrHGDPVHLADLIRRHGVTVIHFVPAM----LAAFNEVLGAGvgELTSLR-LIQTGgeAL 250
Cdd:cd05929    183 PFRWSMTALFMGGTLVLME---KFDPEEFLRLIERYRVTFAQFVPTMfvrlLKLPEAVRNAY--DLSSLKrVIHAA--AP 255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  251 TPPVARDLMVRLPGTRLQNQYGPAEASIVVTIhrvTQDDRVIPIGTPTRRVSARV--LDAALREVPIGVPGELYLGGVQl 328
Cdd:cd05929    256 CPPWVKEQWIDWGGPIIWEYYGGTEGQGLTII---NGEEWLTHPGSVGRAVLGKVhiLDEDGNEVPPGEIGEVYFANGP- 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  329 ARGYAGRPDLTAERFVADPFgepgarlyRT-GDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA 407
Cdd:cd05929    332 GFEYTNDPEKTAAARNEGGW--------STlGDVGYLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAV 403

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  408 -AVVDGPGGQQLVGYLAPADvDVDTVAATTAEL-------LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:cd05929    404 vGVPDEELGQRVHAVVQPAP-GADAGTALAEELiaflrdrLSRYKCPRSIEFVAELPRDDTGKLYRRLL 471

PRK07514

malonyl-CoA synthase; Validated

1-470

4.20e-16

malonyl-CoA synthase; Validated

Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 84.54 E-value: 4.20e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGV--GAEVAVgiQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVV 78
Cdd:PRK07514    29 YTYGDLDAASARLANLLVALGVkpGDRVAV--QVEKSPEALALYLATLRAGAVFLPLNTAYTLAELDYFIGDAEPALVVC 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   79 TSDGEAEARSRFDDIVDVHVLDISSPGDADLDEEEFAGPTRPANAAFT-------LFTSGSTGRPKAVVITHRGIANRLA 151
Cdd:PRK07514   107 DPANFAWLSKIAAAAGAPHVETLDADGTGSLLEAAAAAPDDFETVPRGaddlaaiLYTSGTTGRSKGAMLSHGNLLSNAL 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  152 ADIEQYDLTARDVFLYKAPItFDVSvreiFLPIAIGATLV-----IAEPGRhgDPVHLADLIRRhgVTVIHFVPA----M 222
Cdd:PRK07514   187 TLVDYWRFTPDDVLIHALPI-FHTH----GLFVATNVALLagasmIFLPKF--DPDAVLALMPR--ATVMMGVPTfytrL 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  223 LA--AFNEVLGAGVgeltslRLIQTGGEALTPPVARDLMVRlPGTRLQNQYGPAEAsIVVTIHRVTQDDRVIPIGTPTRR 300
Cdd:PRK07514   258 LQepRLTREAAAHM------RLFISGSAPLLAETHREFQER-TGHAILERYGMTET-NMNTSNPYDGERRAGTVGFPLPG 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  301 VSARVLD-AALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQ 379
Cdd:PRK07514   330 VSLRVTDpETGAELPPGEIGMIEVKGPNVFKGYWRMPEKTAEEFRADGF-------FITGDLGKIDERGYVHIVGRGKDL 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  380 VKLRGQRLELGEVEAALAAAPGVLHAA--------------AAVVDGPGgqqlvgylapADVDVDTVAATTAELLPEYMR 445
Cdd:PRK07514   403 IISGGYNVYPKEVEGEIDELPGVVESAvigvphpdfgegvtAVVVPKPG----------AALDEAAILAALKGRLARFKQ 472

                          490       500
                   ....*....|....*....|....*
gi 1827387616  446 PSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK07514   473 PKRVFFVDELPRNTMGKVQKNLLRE 497

PRK13388

acyl-CoA synthetase; Provisional

28-468

4.57e-16

acyl-CoA synthetase; Provisional

Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 84.69 E-value: 4.57e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   28 VGIQIDRSVEQVVAIHAVAMAGGHFVPLDeqlPVDRARYM---VRTAGVRLVVVtsdgEAEARSRFD--DIVDVHVLDIS 102
Cdd:PRK13388    55 VGVLLGNTPEMLFWLAAAALGGYVLVGLN---TTRRGAALaadIRRADCQLLVT----DAEHRPLLDglDLPGVRVLDVD 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  103 SPGDAD-LDEEEFAGPTRPANAAFT---LFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVR 178
Cdd:PRK13388   128 TPAYAElVAAAGALTPHREVDAMDPfmlIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRDDVCYVSMPLFHSNAVM 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  179 EIFLP-IAIGATlvIAEPGRHGDPVHLADlIRRHGVTVIHFVPAMLA---AFNEVLGAGVGELTslrlIQTGGEAltPPV 254
Cdd:PRK13388   208 AGWAPaVASGAA--VALPAKFSASGFLDD-VRRYGATYFNYVGKPLAyilATPERPDDADNPLR----VAFGNEA--SPR 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  255 ARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQ-------DDRVIPIGTPTRRVSAR-VLDAALREV-PIGVPGELY-LG 324
Cdd:PRK13388   279 DIAEFSRRFGCQVEDGYGSSEGAVIVVREPGTPpgsigrgAPGVAIYNPETLTECAVaRFDAHGALLnADEAIGELVnTA 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  325 GVQLARGYAGRPDLTAERFvadpfgepgaR--LYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGV 402
Cdd:PRK13388   359 GAGFFEGYYNNPEATAERM----------RhgMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAI 428

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  403 LHAAA-AVVDGPGGQQLVGYLAPADVDVDTVAATTAEL-----LPEYMRPSaWVRL-DAMPLSRSGKVDRRLL 468
Cdd:PRK13388   429 NRVAVyAVPDERVGDQVMAALVLRDGATFDPDAFAAFLaaqpdLGTKAWPR-YVRIaADLPSTATNKVLKREL 500

A_NRPS_MycA_like

cd05908

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...

1184-1532

6.07e-16

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 83.69 E-value: 6.07e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1184 LAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHVASPSFDASM--FEMAWAIpAGHTLVIAPQA 1261
Cdd:cd05908    108 LAFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKD----RILSWMPLTHDMGLiaFHLAPLI-AGMNQYLMPTR 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1262 DFAGDALATVLERDEVTDMIIT-PS-----VLATVDPERAQ-----YVRNLATGGEACPPELVE----RWSERGRR---I 1323
Cdd:cd05908    183 LFIRRPILWLKKASEHKATIVSsPNfgykyFLKTLKPEKANdwdlsSIRMILNGAEPIDYELCHefldHMSKYGLKrnaI 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNCYGPTEATVWAT--------------RSRMTAGKP--------------VTIGKPVDGFTVRVLDGRLHEVPQGVVGE 1375
Cdd:cd05908    263 LPVYGLAEASVGASlpkaqspfktitlgRRHVTHGEPepevdkkdsecltfVEVGKPIDETDIRICDEDNKILPDGYIGH 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1376 LYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKgGNLEFAGRADHQVKINGQRVELGEIEAVLDAQP 1455
Cdd:cd05908    343 IQIRGKNVTPGYYNNPEATAKVFTDDGW-------LKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHDIERIAEELE 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1456 GV--AQSVVVGVESTRggRKHTEVVAYLVAKpgATIDSAAVLdeaAQHLAAHMVP------SQAIVIDEIPLTPAGKLDR 1527
Cdd:cd05908    415 GVelGRVVACGVNNSN--TRNEEIFCFIEHR--KSEDDFYPL---GKKIKKHLNKrggwqiNEVLPIRRIPKTTSGKVKR 487


                   ....*
gi 1827387616 1528 AALPE 1532
Cdd:cd05908    488 YELAQ 492

PRK07008

long-chain-fatty-acid--CoA ligase; Validated

1064-1532

6.11e-16

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 83.99 E-value: 6.11e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDaST 1143
Cdd:PRK07008    42 YRDCERRAKQLAQALAALGVEPGDRVGTLAWNGYRHLEAYYGVSGSGAVCHTINPRLFPEQIAYIVNHAEDRYVLFD-LT 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1144 RARLGES---SCE----WVDLAD---LEA------------EAESGD-DITDTERNGSvrltnlAYLIYTSGSTGRPKAV 1200
Cdd:PRK07008   121 FLPLVDAlapQCPnvkgWVAMTDaahLPAgstpllcyetlvGAQDGDyDWPRFDENQA------SSLCYTSGTTGNPKGA 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1201 GVSHTGIV--DFVNSLAKITTGTPEDEpdtrILHVAsPSFDASmfemAWAIPAGHTLVIA----PQADFAGDALATVLER 1274
Cdd:PRK07008   195 LYSHRSTVlhAYGAALPDAMGLSARDA----VLPVV-PMFHVN----AWGLPYSAPLTGAklvlPGPDLDGKSLYELIEA 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1275 DEVTDMIITPSV----LATVDPERAQY--VRNLATGGEACPPELVERWS-ERGRRIFNCYGPTEATVWATRSRMTA---G 1344
Cdd:PRK07008   266 ERVTFSAGVPTVwlglLNHMREAGLRFstLRRTVIGGSACPPAMIRTFEdEYGVEVIHAWGMTEMSPLGTLCKLKWkhsQ 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 KPVTI--------GKPVDGFTVRVLDGRLHEVP-QGVV-GELYLSTAGLARGYLGRPGQTAVsfvadpfgepgARMYATG 1414
Cdd:PRK07008   346 LPLDEqrkllekqGRVIYGVDMKIVGDDGRELPwDGKAfGDLQVRGPWVIDRYFRGDASPLV-----------DGWFPTG 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVaylVAKPGATIDSAAV 1494
Cdd:PRK07008   415 DVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVV---VKRPGAEVTREEL 491

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 1827387616 1495 LDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK07008   492 LAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLRE 529

E_NRPS

cd19534

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

572-994

6.26e-16

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 83.07 E-value: 6.26e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  572 PLSRAQRrmWFLNQFDTASGAYNIPAALTLAGDVDETLLFDSLCDVVERHEVLRTVYPSVGAAPVQDVLPVA---VAREQ 648
Cdd:cd19534      3 PLTPIQR--WFFEQNLAGRHHFNQSVLLRVPQGLDPDALRQALRALVEHHDALRMRFRREDGGWQQRIRGDVeelFRLEV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  649 LDWREADS---VESLVRSTTEGFDVsTQMPL--RGRFHRDGAGLHVALTMHHIAMDGQSIPVLARDLMSAYAARAEGRTG 723
Cdd:cd19534     81 VDLSSLAQaaaIEALAAEAQSSLDL-EEGPLlaAALFDGTDGGDRLLLVIHHLVVDGVSWRILLEDLEAAYEQALAGEPI 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  724 GLPvLDVQYADYALWQQSVLGDADDEtsvlgEQLSHWRRVLAglPAVTDLPMDRPRpavlgTAGATVTVEFDDDLADRVD 803
Cdd:cd19534    160 PLP-SKTSFQTWAELLAEYAQSPALL-----EELAYWRELPA--ADYWGLPKDPEQ-----TYGDARTVSFTLDEEETEA 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  804 VLARSNTMTGfmvTE------AAFAATVARLASTTDVVIGTPVAGRnDPALEEL-----IGMFvnTLL--LRTQVDPGHS 870
Cdd:cd19534    227 LLQEANAAYR---TEindlllAALALAFQDWTGRAPPAIFLEGHGR-EEIDPGLdlsrtVGWF--TSMypVVLDLEASED 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  871 VGDLLGNVRTTvLDAFANDQVQFDELIEALAPERSS-SHQPLAQIAFTYTEPTVNDVAGlEASGIQAAPVDTGVVNAK-- 947
Cdd:cd19534    301 LGDTLKRVKEQ-LRRIPNKGIGYGILRYLTPEGTKRlAFHPQPEISFNYLGQFDQGERD-DALFVSAVGGGGSDIGPDtp 378

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616  948 ----FDLTVAVrarSGGTpMAADFIYATDLFDESTVKRFAEVYRRVLQAIV 994
Cdd:cd19534    379 rfalLDINAVV---EGGQ-LVITVSYSRNMYHEETIQQLADSYKEALEALI 425

PRK06710

long-chain-fatty-acid--CoA ligase; Validated

2561-3061

7.29e-16

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 83.93 E-value: 7.29e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2561 ATDPVTLAELFRAAARRAPDHVAVvDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTG 2640
Cdd:PRK06710    20 SYDIQPLHKYVEQMASRYPEKKAL-HFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2641 GAYVPIDPDYPAERVASMIEDSGAVLGLSVlasgdlpgqEFEWMRLDDDSVAAEIAAVPAGPITD--------------- 2705
Cdd:PRK06710    99 GIVVQTNPLYTERELEYQLHDSGAKVILCL---------DLVFPRVTNVQSATKIEHVIVTRIADflpfpknllypfvqk 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2706 --------------------AERlgEVTAA---------NLAYVIYTSGSTGRPKGVAVTHSGLAN---------FARQE 2747
Cdd:PRK06710   170 kqsnlvvkvsesetihlwnsVEK--EVNTGvevpcdpenDLALLQYTGGTTGFPKGVMLTHKNLVSntlmgvqwlYNCKE 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2748 SDRLNAGDNPV--VLGFASpSFDASVLE-YLLATVNEGTLAYrPSEAVGGEVLERFIAEHGATHTFLTPSVLSTMDptaV 2824
Cdd:PRK06710   248 GEEVVLGVLPFfhVYGMTA-VMNLSIMQgYKMVLIPKFDMKM-VFEAIKKHKVTLFPGAPTIYIALLNSPLLKEYD---I 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2825 PSLRVIAAGGEAVPQPIVDRWAPAT--ELHNLYGPTETTiGITISSAM-RPGDPVRLGGPIGGVDLMVLD----ERLRPv 2897
Cdd:PRK06710   323 SSIRACISGSAPLPVEVQEKFETVTggKLVEGYGLTESS-PVTHSNFLwEKRVPGSIGVPWPDTEAMIMSletgEALPP- 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2898 pvGMPGELYVAGGALSRGYLDRSGLTAerftanpyGTAGQRMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIE 2977
Cdd:PRK06710   401 --GEIGEIVVKGPQIMKGYWNKPEETA--------AVLQDGWLHTGDVGY----MDEDGF-FYVKDRKKDMIVASGFNVY 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2978 LGEIEAVLAEHDAVESAVVLGVGGSV-ATALAAYIVPVDGAV-EVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLD 3055
Cdd:PRK06710   466 PREVEEVLYEHEKVQEVVTIGVPDPYrGETVKAFVVLKEGTEcSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKIL 545


                   ....*.
gi 1827387616 3056 KRALPE 3061
Cdd:PRK06710   546 RRVLIE 551

PRK08162

acyl-CoA synthetase; Validated

1050-1532

8.58e-16

acyl-CoA synthetase; Validated

Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 83.84 E-value: 8.58e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVgMERSIGSVL-ATWGVIKSGAAYVPVDPAYPADRIAYM 1128
Cdd:PRK08162    32 PDRPAVIHGDRRRTWAETYARCRRLASALARRGIGRGDTVAV-LLPNIPAMVeAHFGVPMAGAVLNTLNTRLDAASIAFM 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1129 LEDSGATVGITD----ASTRARLGESSCEW---VDLADleAEAESGDDITDTERNGSVRLTNLAY-------------LI 1188
Cdd:PRK08162   111 LRHGEAKVLIVDtefaEVAREALALLPGPKplvIDVDD--PEYPGGRFIGALDYEAFLASGDPDFawtlpadewdaiaLN 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1189 YTSGSTGRPKAVGVSHTGIvdFVNSLAKITTGtpeDEPDTRILHVASPSFDASMFEMAWAIPA-GHTLVIAPQADfaGDA 1267
Cdd:PRK08162   189 YTSGTTGNPKGVVYHHRGA--YLNALSNILAW---GMPKHPVYLWTLPMFHCNGWCFPWTVAArAGTNVCLRKVD--PKL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1268 LATVLERDEVTDMIITPSVLATVDPERAQYVRNLA------TGGEACPPELVERWSERGRRIFNCYGPTE----ATV--- 1334
Cdd:PRK08162   262 IFDLIREHGVTHYCGAPIVLSALINAPAEWRAGIDhpvhamVAGAAPPAAVIAKMEEIGFDLTHVYGLTEtygpATVcaw 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 ---WAT-----RSRMTAGKPVTIgKPVDGftVRVLDGR-LHEVPQG--VVGELYLSTAGLARGYLGRPGQTAVSFVADPF 1403
Cdd:PRK08162   342 qpeWDAlpldeRAQLKARQGVRY-PLQEG--VTVLDPDtMQPVPADgeTIGEIMFRGNIVMKGYLKNPKATEEAFAGGWF 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1404 gepgarmyATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEV-VAYLV 1482
Cdd:PRK08162   419 --------HTGDLAVLHPDGYIKIKDRSKDIIISGGENISSIEVEDVLYRHPAVLVAAVVAKPDPKWG----EVpCAFVE 486

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1483 AKPGATIDSAAVLDEAAQHLAAHMVPSqAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PRK08162   487 LKDGASATEEEIIAHCREHLAGFKVPK-AVVFGELPKTSTGKIQKFVLRE 535

PRK13388

acyl-CoA synthetase; Provisional

2564-3059

1.21e-15

acyl-CoA synthetase; Provisional

Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 83.15 E-value: 1.21e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAaaRRAPDHVAVVDGaGARLTYRELDEASDRLARWLIG--RGVGPERaVALAIGRSAQLLTAIWAVAKTGG 2641
Cdd:PRK13388     2 RDTIAQLLRD--RAGDDTIAVRYG-DRTWTWREVLAEAAARAAALIAlaDPDRPLH-VGVLLGNTPEMLFWLAAAALGGY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2642 AYVPIDPDYPAERVASMIE--DSGAVL----GLSVLASGDLPGQEFewMRLDDDSVAAEIAAVPagpitDAERLGEVTAA 2715
Cdd:PRK13388    78 VLVGLNTTRRGAALAADIRraDCQLLVtdaeHRPLLDGLDLPGVRV--LDVDTPAYAELVAAAG-----ALTPHREVDAM 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDR--LNAGDnpvVLGFASPSF--DASVLEYLLATVNEGTLAYRPSEA 2791
Cdd:PRK13388   151 DPFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERfgLTRDD---VCYVSMPLFhsNAVMAGWAPAVASGAAVALPAKFS 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 VGGEVLErfIAEHGAthTFLT------PSVLST--MDPTAVPSLRViAAGGEAVPQPI---VDRWapATELHNLYGPTET 2860
Cdd:PRK13388   228 ASGFLDD--VRRYGA--TYFNyvgkplAYILATpeRPDDADNPLRV-AFGNEASPRDIaefSRRF--GCQVEDGYGSSEG 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2861 TIGITISSAMRPGDpvrLGGPIGGVdlMVLD-ERLRPVPVGM-------------PGELY-VAGGALSRGYLDRSGLTAE 2925
Cdd:PRK13388   301 AVIVVREPGTPPGS---IGRGAPGV--AIYNpETLTECAVARfdahgallnadeaIGELVnTAGAGFFEGYYNNPEATAE 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2926 RFTANpygtagqrMYRTGDVVRwtpdTDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV-GGSVA 3004
Cdd:PRK13388   376 RMRHG--------MYWSGDLAY----RDADGW-IYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVpDERVG 442

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 3005 TALAAYIVPVDGA-VEVSELKAFAGGR--LPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK13388   443 DQVMAALVLRDGAtFDPDAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKREL 500

FATP_FACS

cd05940

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...

2589-3049

1.30e-15

Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 82.40 E-value: 1.30e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2589 GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGayvpidpdypaerVASMIED--SGAVL 2666
Cdd:cd05940      1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGA-------------VAALINYnlRGESL 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2667 GLSVLASGDLpgqefewmrldddsvaaeiaavpagpitdaerlgeVTAANLAYVIYTSGSTGRPKGVAVTHSGLANFAR- 2745
Cdd:cd05940     68 AHCLNVSSAK-----------------------------------HLVVDAALYIYTSGTTGLPKAAIISHRRAWRGGAf 112

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2746 -QESDRLNAGDnpvVLGFASPSFDASVLEYLLATV--NEGTLAYRpseavggevlERFIAEHgathtFLTPSVlsTMDPT 2822
Cdd:cd05940    113 fAGSGGALPSD---VLYTCLPLYHSTALIVGWSAClaSGATLVIR----------KKFSASN-----FWDDIR--KYQAT 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2823 AVPSLrviaagGE------AVPQPIVDR----------------WAPATELHNL------YGPTETTIGIT-----ISSA 2869
Cdd:cd05940    173 IFQYI------GElcryllNQPPKPTERkhkvrmifgnglrpdiWEEFKERFGVpriaefYAATEGNSGFInffgkPGAI 246

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2870 MRPGDPVRLGGPIGGVDLMVLDERL--------RPVPVGMPGELYVAGGALSR--GYLDRSglTAERFTANPYGTAGQRM 2939
Cdd:cd05940    247 GRNPSLLRKVAPLALVKYDLESGEPirdaegrcIKVPRGEPGLLISRINPLEPfdGYTDPA--ATEKKILRDVFKKGDAW 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2940 YRTGDVVRWtpdtDTGGLTlEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV--GGSVATA-LAAYIVPVDG 3016
Cdd:cd05940    325 FNTGDLMRL----DGEGFW-YFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVqvPGTDGRAgMAAIVLQPNE 399

                          490       500       510
                   ....*....|....*....|....*....|...
gi 1827387616 3017 AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLT 3049
Cdd:cd05940    400 EFDLSALAAHLEKNLPGYARPLFLRLQPEMEIT 432

Firefly_Luc

cd17642

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...

101-470

1.32e-15

Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 82.96 E-value: 1.32e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  101 ISSPGDADLDEEEFAGPT--RPANAAFTLFTSGSTGRPKAVVITHRGIANRLAadieqydlTARDVFLYKAPI--TFDVS 176
Cdd:cd17642    162 ITQNLPPGFNEYDFKPPSfdRDEQVALIMNSSGSTGLPKGVQLTHKNIVARFS--------HARDPIFGNQIIpdTAILT 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  177 VREIFLPIAIGATLVIAEPG-------RHGDPVHLADLiRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEA 249
Cdd:cd17642    234 VIPFHHGFGMFTTLGYLICGfrvvlmyKFEEELFLRSL-QDYKVQSALLVPTLFAFFAKSTLVDKYDLSNLHEIASGGAP 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  250 LTPPVARDLMVR--LPGTRlqNQYGPAEASIVVTIHRVTqDDRVIPIGTPTRRVSARVLDAALREVpIGV--PGELYLGG 325
Cdd:cd17642    313 LSKEVGEAVAKRfkLPGIR--QGYGLTETTSAILITPEG-DDKPGAVGKVVPFFYAKVVDLDTGKT-LGPneRGELCVKG 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  326 VQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHA 405
Cdd:cd17642    389 PMIMKGYVNNPEATKALIDKDGW-------LHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDA 461

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  406 AAAVVDGPGGqqlvGYLAPADVDVDTVAATTAELLPEYM----RPSAWVR-----LDAMPLSRSGKVDRRLLPE 470
Cdd:cd17642    462 GVAGIPDEDA----GELPAAVVVLEAGKTMTEKEVMDYVasqvSTAKRLRggvkfVDEVPKGLTGKIDRRKIRE 531

PRK13388

acyl-CoA synthetase; Provisional

1038-1530

1.73e-15

acyl-CoA synthetase; Provisional

Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 82.77 E-value: 1.73e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQRdLDPDHPALICDGTEMDYDEFetRTNAIARALLARGVSPEDV---VAVGMERSIGSVLATWGVIKSGAAYV 1114
Cdd:PRK13388     4 TIAQLLRDR-AGDDTIAVRYGDRTWTWREV--LAEAAARAAALIALADPDRplhVGVLLGNTPEMLFWLAAAALGGYVLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1115 PVDPAYPADRIAYMLEDSGATVGITDASTRARLGE-----------SSCEWVDLADLEAEAESGDDITDTerngsvrltN 1183
Cdd:PRK13388    81 GLNTTRRGAALAADIRRADCQLLVTDAEHRPLLDGldlpgvrvldvDTPAYAELVAAAGALTPHREVDAM---------D 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1184 LAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSF--DASMFEMAWAIPAGHTLVIAPQa 1261
Cdd:PRK13388   152 PFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRDD-----VCYVSMPLFhsNAVMAGWAPAVASGAAVALPAK- 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1262 dFAGDALATVLERDEVTDMIITPSVLATV--DPERAQYVRN---LATGGEAcPPELVERWSER-GRRIFNCYGPTEATVW 1335
Cdd:PRK13388   226 -FSASGFLDDVRRYGATYFNYVGKPLAYIlaTPERPDDADNplrVAFGNEA-SPRDIAEFSRRfGCQVEDGYGSSEGAVI 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1336 ATRSRMTAgkPVTIGKPVDGftVRVLD---------------GRLHEvPQGVVGELyLSTAGLAR--GYLGRPGQTAVSF 1398
Cdd:PRK13388   304 VVREPGTP--PGSIGRGAPG--VAIYNpetltecavarfdahGALLN-ADEAIGEL-VNTAGAGFfeGYYNNPEATAERM 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1399 vadpfgepgaR--MYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhTE 1476
Cdd:PRK13388   378 ----------RhgMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPDERVG---DQ 444

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 1477 VVAYLVAKPGATIDSAAVLD--EAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK13388   445 VMAALVLRDGATFDPDAFAAflAAQPDLGTKAWPRYVRIAADLPSTATNKVLKREL 500

PrpE

cd05967

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...

1154-1530

2.14e-15

Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 82.75 E-value: 2.14e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1154 WVDLADLEAEAESGDDITdterngsVRLTNLAYLIYTSGSTGRPKAVgVSHTG--IVDFVNSLAKITTGTPEDEpdtril 1231
Cdd:cd05967    209 DLDWSELLAKAEPVDCVP-------VAATDPLYILYTSGTTGKPKGV-VRDNGghAVALNWSMRNIYGIKPGDV------ 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1232 hvaspSFDASmfEMAWAIpaGHTLVI-------APQADFAG------DALA--TVLERDEVTDMIITPSVLATV--DPER 1294
Cdd:cd05967    275 -----WWAAS--DVGWVV--GHSYIVygpllhgATTVLYEGkpvgtpDPGAfwRVIEKYQVNALFTAPTAIRAIrkEDPD 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1295 AQYV--------RNLATGGEACPPELVErWSER--GRRIFNCYGPTEaTVWATRSR-----MTAGKPVTIGKPVDGFTVR 1359
Cdd:cd05967    346 GKYIkkydlsslRTLFLAGERLDPPTLE-WAENtlGVPVIDHWWQTE-TGWPITANpvglePLPIKAGSPGKPVPGYQVQ 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1360 VLDGRLHEVPQGVVGELYLSTAgLARGYLGRPGQTAVSFVADPFGE-PGarMYATGDLVRVAKGGNLEFAGRADHQVKIN 1438
Cdd:cd05967    424 VLDEDGEPVGPNELGNIVIKLP-LPPGCLLTLWKNDERFKKLYLSKfPG--YYDTGDAGYKDEDGYLFIMGRTDDVINVA 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1439 GQRVELGEIEAVLDAQPGVAQSVVVGVE-STRGGRkhteVVAYLVAKPGATIDSAAVLDEAAQH----LAAHMVPSQAIV 1513
Cdd:cd05967    501 GHRLSTGEMEESVLSHPAVAECAVVGVRdELKGQV----PLGLVVLKEGVKITAEELEKELVALvreqIGPVAAFRLVIF 576

                          410
                   ....*....|....*..
gi 1827387616 1514 IDEIPLTPAGKLDRAAL 1530
Cdd:cd05967    577 VKRLPKTRSGKILRRTL 593

PRK13391

acyl-CoA synthetase; Provisional

4-468

2.28e-15

acyl-CoA synthetase; Provisional

Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 82.05 E-value: 2.28e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:PRK13391    28 RELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPAEAAYIVDDSGARALITSAAKL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEARSRFDDIVDV-HVLDISSPGDAD----LDEEEFAGPTRPANAAFT----LFTSGSTGRPKAV--------VITHRGI 146
Cdd:PRK13391   108 DVARALLKQCPGVrHRLVLDGDGELEgfvgYAEAVAGLPATPIADESLgtdmLYSSGTTGRPKGIkrplpeqpPDTPLPL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  147 ANRLAadiEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEpgrHGDPVHLADLIRRHGVTVIHFVPAM---- 222
Cdd:PRK13391   188 TAFLQ---RLWGFRSDMVYLSPAPLYHSAPQRAVMLVIRLGGTVIVME---HFDAEQYLALIEEYGVTHTQLVPTMfsrm 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  223 LAAFNEVLGAgvGELTSLRlIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTI-------HRVTQdDRVIpIG 295
Cdd:PRK13391   262 LKLPEEVRDK--YDLSSLE-VAIHAAAPCPPQVKEQMIDWWGPIIHEYYAATEGLGFTACdseewlaHPGTV-GRAM-FG 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  296 TPtrrvsaRVLDAALREVPIGVPGELYL-GGVQLArgYAGRPDLTAERFVADPfgepgaRLYRTGDRARWNRDGeieYLG 374
Cdd:PRK13391   337 DL------HILDDDGAELPPGEPGTIWFeGGRPFE--YLNDPAKTAEARHPDG------TWSTVGDIGYVDEDG---YLY 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  375 RTD---FQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADvDVDTVAATTAELLpEYMR----- 445
Cdd:PRK13391   400 LTDraaFMIISGGVNIYPQEAENLLITHPKVADAAVfGVPNEDLGEEVKAVVQPVD-GVDPGPALAAELI-AFCRqrlsr 477

                          490       500
                   ....*....|....*....|....*.
gi 1827387616  446 ---PSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK13391   478 qkcPRSIDFEDELPRLPTGKLYKRLL 503

C_NRPS-like

cd19066

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

1642-2069

2.30e-15

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 81.30 E-value: 2.30e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1642 WMIEHSEEPADFadFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTR-SGDGWTMNAGAGIVPAVREIDAEGALD 1720
Cdd:cd19066     12 WFLKKLATDPSA--FNVAIEMFLTGSLDLARLKQALDAVMERHDVLRTRFCEeAGRYEQVVLDKTVRFRIEIIDLRNLAD 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1721 PalvDAH-RELLGAM-----DPGTGSLLGTA-VVNGEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRP 1793
Cdd:cd19066     90 P---EARlLELIDQIqqtiyDLERGPLVRVAlFRLADERDVLVVAIHHIIVDGGSFQILFEDISSVYDAAERQKPTLPPP 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1794 eatTTRRIAHLLAGQVH----ARAREVDYWLEQLPERPTSFGTSADRPLHRRRDESSLT--YVVDDVAGSILTTVPQAFG 1867
Cdd:cd19066    167 ---VGSYADYAAWLEKQleseAAQADLAYWTSYLHGLPPPLPLPKAKRPSQVASYEVLTleFFLRSEETKRLREVARESG 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1868 SSVDDVLLGALARAVRAWQldngiaDGGPVTVSTEGHGRDESiagdegaiDLSRTVGWFTSITPLAVDASSDVV---HAV 1944
Cdd:cd19066    244 TTPTQLLLAAFALALKRLT------ASIDVVIGLTFLNRPDE--------AVEDTIGLFLNLLPLRIDTSPDATfpeLLK 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1945 KSAKDARLSRPAGGVGFGIL--RYNSDGEIAHRPLPTIMYNYFGGGtapstetAPDDFLPVSdRPNMPssiTGAMRSPSV 2022
Cdd:cd19066    310 RTKEQSREAIEHQRVPFIELvrHLGVVPEAPKHPLFEPVFTFKNNQ-------QQLGKTGGF-IFTTP---VYTSSEGTV 378

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616 2023 FGINISTAGREERRLEAKVTYATDALDEAAASDIARRWHDELRAVVE 2069
Cdd:cd19066    379 FDLDLEASEDPDGDLLLRLEYSRGVYDERTIDRFAERYMTALRQLIE 425

PRK04319

acetyl-CoA synthetase; Provisional

2580-3059

2.54e-15

acetyl-CoA synthetase; Provisional

Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 82.25 E-value: 2.54e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2580 DHVAV--VDGAGAR-LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVA 2656
Cdd:PRK04319    59 DKVALryLDASRKEkYTYKELKELSNKFANVLKELGVEKGDRVFIFMPRIPELYFALLGALKNGAIVGPLFEAFMEEAVR 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2657 SMIEDSGAVLGLSVLA------SGDLPgqEFEWMRLDDDSVAAEiaavpaGPITDAERLGE----------VTAANLAYV 2720
Cdd:PRK04319   139 DRLEDSEAKVLITTPAllerkpADDLP--SLKHVLLVGEDVEEG------PGTLDFNALMEqasdefdiewTDREDGAIL 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2721 IYTSGSTGRPKGV------AVTHSGLANFAR--QESDR---------------------LNAGDNPVVLGFASPSFDASV 2771
Cdd:PRK04319   211 HYTSGSTGKPKGVlhvhnaMLQHYQTGKYVLdlHEDDVywctadpgwvtgtsygifapwLNGATNVIDGGRFSPERWYRI 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2772 LEYLLATV--NEGTlAYRPSEAVGGEVLERFiaehgathtfltpsvlstmdptAVPSLRVIAAGGEAVpQPIVDRWAPAT 2849
Cdd:PRK04319   291 LEDYKVTVwyTAPT-AIRMLMGAGDDLVKKY----------------------DLSSLRHILSVGEPL-NPEVVRWGMKV 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2850 ---ELHNLYGPTETTiGITISS--AM--RPGDpvrLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGG--ALSRGYLDRS 2920
Cdd:PRK04319   347 fglPIHDNWWMTETG-GIMIANypAMdiKPGS---MGKPLPGIEAAIVDDQGNELPPNRMGNLAIKKGwpSMMRGIWNNP 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2921 gltaERFtaNPYGTAGqrMYRTGDVVR-------WtpdtdtggltleYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVES 2993
Cdd:PRK04319   423 ----EKY--ESYFAGD--WYVSGDSAYmdedgyfW------------FQGRVDDVIKTSGERVGPFEVESKLMEHPAVAE 482

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 2994 AVVLGVGGSVATAL-AAYIVPVDGaVEVS-----ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK04319   483 AGVIGKPDPVRGEIiKAFVALRPG-YEPSeelkeEIRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRRVL 553

PRK07529

AMP-binding domain protein; Validated

4-463

2.67e-15

AMP-binding domain protein; Validated

Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 82.31 E-value: 2.67e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAvAMAGGHFVPLDEQLPVDRARYMVRTAGVRlVVVTSDGE 83
Cdd:PRK07529    62 AELLADVTRTANLLHSLGVGPGDVVAFLLPNLPETHFALWG-GEAAGIANPINPLLEPEQIAELLRAAGAK-VLVTLGPF 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 ---------AEARSR---FDDIVDVHVLDISSP---------------GDADLDEE---------EFAGPTRPANAAFTL 127
Cdd:PRK07529   140 pgtdiwqkvAEVLAAlpeLRTVVEVDLARYLPGpkrlavplirrkahaRILDFDAElarqpgdrlFSGRPIGPDDVAAYF 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRG-IANRLAADiEQYDLTARDVFLYKAPItFDV--SVREIFLPIAIGATLVIAEP-GRHGDPV- 202
Cdd:PRK07529   220 HTGGTTGMPKLAQHTHGNeVANAWLGA-LLLGLGPGDTVFCGLPL-FHVnaLLVTGLAPLARGAHVVLATPqGYRGPGVi 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  203 -HLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVgELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVT 281
Cdd:PRK07529   298 aNFWKIVERYRINFLSGVPTVYAALLQVPVDGH-DISSLRYALCGAAPLPVEVFRRFEAAT-GVRIVEGYGLTEATCVSS 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  282 IHRVTQDDRVIPIGT--PTRRVSARVLDAA---LREVPIGVPGELYLGGVQLARGYagrpdlTAERFVADPFGEPgaRLY 356
Cdd:PRK07529   376 VNPPDGERRIGSVGLrlPYQRVRVVILDDAgryLRDCAVDEVGVLCIAGPNVFSGY------LEAAHNKGLWLED--GWL 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  357 RTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYlapadVDVDTVAAT 435
Cdd:PRK07529   448 NTGDLGRIDADGYFWLTGRAKDLIIRGGHNIDPAAIEEALLRHPAVALAAAvGRPDAHAGELPVAY-----VQLKPGASA 522

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1827387616  436 TAELLPEYMR---------PSAWVRLDAMPLSRSGKV 463
Cdd:PRK07529   523 TEAELLAFARdhiaeraavPKHVRILDALPKTAVGKI 559

E_NRPS

cd19534

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

2108-2534

3.56e-15

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 80.76 E-value: 3.56e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2108 PMTPLQQgLFFQADLANTvaDHdaidvYVTQTVLSLTGDVDPGRLRSALSELLARQRVLRSGFVRlPSGAAVTVVPAEVT 2187
Cdd:cd19534      3 PLTPIQR-WFFEQNLAGR--HH-----FNQSVLLRVPQGLDPDALRQALRALVEHHDALRMRFRR-EDGGWQQRIRGDVE 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2188 vpwSVIDLRAEDAASLDSRVE-EVLATERTNPFDMAKPPLIRVVLVE-HGDGAELVVTNHHLLIDGWSSPLVLADLLSLY 2265
Cdd:cd19534     74 ---ELFRLEVVDLSSLAQAAAiEALAAEAQSSLDLEEGPLLAAALFDgTDGGDRLLLVIHHLVVDGVSWRILLEDLEAAY 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2266 ATGQ-TFTGSLP-GTSGRDFADHARAVAT-ADVEAGIAAWREVLAPVTEPtlvAPGHEPSADAPPRDHQFSIDVKVTERL 2342
Cdd:cd19534    151 EQALaGEPIPLPsKTSFQTWAELLAEYAQsPALLEELAYWRELPAADYWG---LPKDPEQTYGDARTVSFTLDEEETEAL 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2343 --EALARNNsTTMATVVQFAWAMFLSRLTGTRTVtfaeTVS----GRSPDIEGMESM--VGMFINTIPAVVDVNPDATVV 2414
Cdd:cd19534    228 lqEANAAYR-TEINDLLLAALALAFQDWTGRAPP----AIFleghGREEIDPGLDLSrtVGWFTSMYPVVLDLEASEDLG 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2415 DVLTAVqNDKVKVLDHQQI--GLPRLVAQTGLPALFDTLAVYESF--------PVNVDSVAGIDASSAGglKLVGAKTsd 2484
Cdd:cd19534    303 DTLKRV-KEQLRRIPNKGIgyGILRYLTPEGTKRLAFHPQPEISFnylgqfdqGERDDALFVSAVGGGG--SDIGPDT-- 377

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2485 ATHYPLNLSASRRGAELALKLKYLPTAFAPEQVAVFADVLTGLLGAIADH 2534
Cdd:cd19534    378 PRFALLDINAVVEGGQLVITVSYSRNMYHEETIQQLADSYKEALEALIEH 427

FACL_like_4

cd05944

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

129-465

5.24e-15

Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 79.45 E-value: 5.24e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  129 TSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPItFDV--SVREIFLPIAIGATLVIAEPGRHGDPVHLAD 206
Cdd:cd05944     10 TGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDDVLLCGLPL-FHVngSVVTLLTPLASGAHVVLAGPAGYRNPGLFDN 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  207 ---LIRRHGVTVIHFVPAMLAAFNEVlgAGVGELTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIH 283
Cdd:cd05944     89 fwkLVERYRITSLSTVPTVYAALLQV--PVNADISSLRFAMSGAAPLPVELRARFEDAT-GLPVVEGYGLTEATCLVAVN 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIPIG--TPTRRVSARVLDAALREV-PIGVP--GELYLGGVQLARGYagrpdlTAERFVADPFGEPGarLYRT 358
Cdd:cd05944    166 PPDGPKRPGSVGlrLPYARVRIKVLDGVGRLLrDCAPDevGEICVAGPGVFGGY------LYTEGNKNAFVADG--WLNT 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  359 GDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGP---GGQQLVGY--LAP-ADVDVDTV 432
Cdd:cd05944    238 GDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAV--AFAGAVGQPdahAGELPVAYvqLKPgAVVEEEEL 315

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1827387616  433 AATTAELLPEYMR-PSAWVRLDAMPLSRSGKVDR 465
Cdd:cd05944    316 LAWARDHVPERAAvPKHIEVLEELPVTAVGKVFK 349

LC_FACS_bac

cd05932

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...

1061-1527

1.16e-14

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 79.82 E-value: 1.16e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGAT---VG 1137
Cdd:cd05932      6 EFTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKalfVG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1138 ITD--ASTRARLGES--SC------------EWVDLADLEAEAEsGDDITDTERngsvrltnLAYLIYTSGSTGRPKavG 1201
Cdd:cd05932     86 KLDdwKAMAPGVPEGliSIslpppsaancqyQWDDLIAQHPPLE-ERPTRFPEQ--------LATLIYTSGTTGQPK--G 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1202 VSHTgivdfVNSLAKITTGTPED---EPDTRIL------HVASPSFdasmFEMAWAIpAGHTLVIAPQAD-FAGDalatv 1271
Cdd:cd05932    155 VMLT-----FGSFAWAAQAGIEHigtEENDRMLsylplaHVTERVF----VEGGSLY-GGVLVAFAESLDtFVED----- 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1272 LERDEVTDMIITP--------SVLATVDPERAQ-----------------------YVRNLATGGEACPPELVERWSERG 1320
Cdd:cd05932    220 VQRARPTLFFSVPrlwtkfqqGVQDKIPQQKLNlllkipvvnslvkrkvlkglgldQCRLAGCGSAPVPPALLEWYRSLG 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1321 RRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDGrlhevpqgvvGELYLSTAGLARGYLGRPGQTAVSFVA 1400
Cdd:cd05932    300 LNILEAYGMTENFAYSHLNYPGRDKIGTVGNAGPGVEVRISED----------GEILVRSPALMMGYYKDPEATAEAFTA 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1401 DPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKIN-GQRVELGEIEAVLDAQPGVAQSVVVGVESTR---------G 1470
Cdd:cd05932    370 DGF-------LRTGDKGELDADGNLTITGRVKDIFKTSkGKYVAPAPIENKLAEHDRVEMVCVIGSGLPAplalvvlseE 442

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1471 GRKHTEVVAY--LVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd05932    443 ARLRADAFARaeLEASLRAHLARVNSTLDSHEQLAGIVVVKDPWSIDNGILTPTLKIKR 501

MACS_like_1

cd05974

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

2592-3054

1.27e-14

Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 79.15 E-value: 1.27e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVlglsvl 2671
Cdd:cd05974      1 VSFAEMSARSSRVANFLRSIGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLRDRVDRGGAV------ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrldddsvaaeIAAVPagpitdaerlgEVTAANLAYVIY-TSGSTGRPKGVAVTHSG--LANFARQES 2748
Cdd:cd05974     75 -----------------------YAAVD-----------ENTHADDPMLLYfTSGTTSKPKLVEHTHRSypVGHLSTMYW 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2749 DRLNAGDnpVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEA-VGGEVLERFIAEHGATHTFLTPSVLSTMDPTAVPSL 2827
Cdd:cd05974    121 IGLKPGD--VHWNISSPGWAKHAWSCFFAPWNAGATVFLFNYArFDAKRVLAALVRYGVTTLCAPPTVWRMLIQQDLASF 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2828 RV----IAAGGEAVPQPIVD--RWAPATELHNLYGPTETTIGITISsamrPGDPVR---LGGPIGGVDLMVLDERLRPVP 2898
Cdd:cd05974    199 DVklreVVGAGEPLNPEVIEqvRRAWGLTIRDGYGQTETTALVGNS----PGQPVKagsMGRPLPGYRVALLDPDGAPAT 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2899 vgmPGELYVAGGA-----LSRGYLDRSGLTAerftanpyGTAGQRMYRTGDVVRWTPDtdtGGLTleYTGRSDDQVKLRG 2973
Cdd:cd05974    275 ---EGEVALDLGDtrpvgLMKGYAGDPDKTA--------HAMRGGYYRTGDIAMRDED---GYLT--YVGRADDVFKSSD 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2974 LRIELGEIEAVLAEHDAVESAVVLGVGGSVATAL-AAYIVPVDGAVEVSELK----AFAGGRLPAYMVPSSFTvIDELPL 3048
Cdd:cd05974    339 YRISPFELESVLIEHPAVAEAAVVPSPDPVRLSVpKAFIVLRAGYEPSPETAleifRFSRERLAPYKRIRRLE-FAELPK 417


                   ....*.
gi 1827387616 3049 TPVGKL 3054
Cdd:cd05974    418 TISGKI 423

PRK12492

long-chain-fatty-acid--CoA ligase; Provisional

236-471

1.32e-14

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 79.87 E-value: 1.32e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  236 ELTSLRLIQTGGEALTPPVArDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPI 315
Cdd:PRK12492   331 DFSALKLTNSGGTALVKATA-ERWEQLTGCTIVEGYGLTETSPVASTNPYGELARLGTVGIPVPGTALKVIDDDGNELPL 409

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  316 GVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:PRK12492   410 GERGELCIKGPQVMKGYWQQPEATAEALDAEGW-------FKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDV 482

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  396 LAAAPGVLHAAA-AVVDGPGGQQLVGYLAPAD--VDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEP 471
Cdd:PRK12492   483 VMAHPKVANCAAiGVPDERSGEAVKLFVVARDpgLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDI 561

PRK12582

acyl-CoA synthetase; Provisional

1043-1463

1.39e-14

acyl-CoA synthetase; Provisional

Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 80.09 E-value: 1.39e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1043 LAQRDldPDHPalicDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPA 1122
Cdd:PRK12582    68 LAQRE--PGHG----QWRKVTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYSL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1123 -----DRIAYMLE---------DSGATVgitdASTRARLGESSCEWVdLADLEAEAESG---DDITDTERNGSV-----R 1180
Cdd:PRK12582   142 mshdhAKLKHLFDlvkprvvfaQSGAPF----ARALAALDLLDVTVV-HVTGPGEGIASiafADLAATPPTAAVaaaiaA 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1181 LT--NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDEPDTrilhvaspsfdaSMFEMAW----------- 1247
Cdd:PRK12582   217 ITpdTVAKYLFTSGSTGMPKAVINTQRMMCANIAMQEQLRPREPDPPPPV------------SLDWMPWnhtmggnanfn 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1248 -AIPAGHTLVIAPQADFAGDALATVLERDEvtdmiITPSVLATV-------------DPE-RAQYVRNLAT---GGEACP 1309
Cdd:PRK12582   285 gLLWGGGTLYIDDGKPLPGMFEETIRNLRE-----ISPTVYGNVpagyamlaeamekDDAlRRSFFKNLRLmayGGATLS 359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1310 PELVERW-----SERGRRI--FNCYGPTEA------TVWATRsrmtagKPVTIGKPVDGFTVRVldgrlheVPQGVVGEL 1376
Cdd:PRK12582   360 DDLYERMqalavRTTGHRIpfYTGYGATETaptttgTHWDTE------RVGLIGLPLPGVELKL-------APVGDKYEV 426

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1377 YLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRV------AKGgnLEFAGRADHQVKI-NGQRVELGEIEA 1449
Cdd:PRK12582   427 RVKGPNVTPGYHKDPELTAAAFDEEGF-------YRLGDAARFvdpddpEKG--LIFDGRVAEDFKLsTGTWVSVGTLRP 497

                          490
                   ....*....|....*
gi 1827387616 1450 -VLDAQPGVAQSVVV 1463
Cdd:PRK12582   498 dAVAACSPVIHDAVV 512

PRK06018

putative acyl-CoA synthetase; Provisional

2564-3061

1.48e-14

putative acyl-CoA synthetase; Provisional

Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 79.80 E-value: 1.48e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAV---VDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTG 2640
Cdd:PRK06018     9 PLLCHRIIDHAARIHGNREVVtrsVEGPIVRTTYAQIHDRALKVSQALDRDGIKLGDRVATIAWNTWRHLEAWYGIMGIG 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2641 GAYVPIDPDYPAERVASMI---EDSGAVLGLSVLA-----SGDLPGQEfEWMRLDDDSVAAEIA---AVPAGPITDAER- 2708
Cdd:PRK06018    89 AICHTVNPRLFPEQIAWIInhaEDRVVITDLTFVPilekiADKLPSVE-RYVVLTDAAHMPQTTlknAVAYEEWIAEADg 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2709 ------LGEVTAANLAYviyTSGSTGRPKGVAVTHSG--LANFARQESDRLNAGDNPVVLGFAsPSFDASVLEYLLATVN 2780
Cdd:PRK06018   168 dfawktFDENTAAGMCY---TSGTTGDPKGVLYSHRSnvLHALMANNGDALGTSAADTMLPVV-PLFHANSWGIAFSAPS 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2781 EGTLAYRPSEAVGGEVLERFIAEHGATHTFLTPSV----LSTMDPT--AVPSLRVIAAGGEAVPQPIVDRWAP-ATELHN 2853
Cdd:PRK06018   244 MGTKLVMPGAKLDGASVYELLDTEKVTFTAGVPTVwlmlLQYMEKEglKLPHLKMVVCGGSAMPRSMIKAFEDmGVEVRH 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2854 LYGPTETTIGITISS-----AMRPGDP-----VRLGGPIGGVDLMVLDERLRPVPVG--MPGELYVAGGALSRGYL--DR 2919
Cdd:PRK06018   324 AWGMTEMSPLGTLAAlkppfSKLPGDArldvlQKQGYPPFGVEMKITDDAGKELPWDgkTFGRLKVRGPAVAAAYYrvDG 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2920 SGLTAERFtanpygtagqrmYRTGDVVrwtpDTDTGGlTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV 2999
Cdd:PRK06018   404 EILDDDGF------------FDTGDVA----TIDAYG-YMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGV 466

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 3000 GGSVATALAAYIVPVDGAVEVS--ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:PRK06018   467 YHPKWDERPLLIVQLKPGETATreEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALRE 530

FCS

cd05921

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...

2575-3008

1.78e-14

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.

Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 79.40 E-value: 1.78e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVVDGAGA----RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDY 2650
Cdd:cd05921      5 ARQAPDRTWLAEREGNggwrRVTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPVSPAY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2651 PA-----ERVASMIE--DSGAV-----------------LGLSVLASGDLPGqefewmrlDDDSVA-AEIAAVPAGPITD 2705
Cdd:cd05921     85 SLmsqdlAKLKHLFEllKPGLVfaqdaapfaralaaifpLGTPLVVSRNAVA--------GRGAISfAELAATPPTAAVD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2706 AERlGEVTAANLAYVIYTSGSTGRPKGVAVTHSGL-ANFARQESDR-LNAGDNPVVLGFA--SPSFDASVlEYLLATVNE 2781
Cdd:cd05921    157 AAF-AAVGPDTVAKFLFTSGSTGLPKAVINTQRMLcANQAMLEQTYpFFGEEPPVLVDWLpwNHTFGGNH-NFNLVLYNG 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2782 GTL---AYRPSEAVGGEVLeRFIAEHGATHTFLTPSVLSTM------DPTAVPS----LRVIAAGGEAVPQPIVDRW--- 2845
Cdd:cd05921    235 GTLyidDGKPMPGGFEETL-RNLREISPTVYFNVPAGWEMLvaalekDEALRRRffkrLKLMFYAGAGLSQDVWDRLqal 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2846 APATELHNL-----YGPTETTIGITISS--AMRPGDpvrLGGPIGGVDLmvlderlRPVPVGMPGELYVAGGALSRGYLD 2918
Cdd:cd05921    314 AVATVGERIpmmagLGATETAPTATFTHwpTERSGL---IGLPAPGTEL-------KLVPSGGKYEVRVKGPNVTPGYWR 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2919 RSGLTAERFTANPYgtagqrmYRTGDVVRWT-PDTDTGGLTleYTGRSDDQVKLR-GLRIELGEI--EAVLAEHDAVESA 2994
Cdd:cd05921    384 QPELTAQAFDEEGF-------YCLGDAAKLAdPDDPAKGLV--FDGRVAEDFKLAsGTWVSVGPLraRAVAACAPLVHDA 454

                          490
                   ....*....|....
gi 1827387616 2995 VVLGVGGSVATALA 3008
Cdd:cd05921    455 VVAGEDRAEVGALV 468

MACS_AAE_MA_like

cd05970

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...

4-465

2.31e-14

Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 79.08 E-value: 2.31e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDG- 82
Cdd:cd05970     51 AELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAIAIPATHQLTAKDIVYRIESADIKMIVAIAEDn 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   83 -----EAEARSRFDDIVDVHVLDISSPGDADLDEE------EFAGPTRPANA-----AFTLFTSGSTGRPKAVVITHRGI 146
Cdd:cd05970    131 ipeeiEKAAPECPSKPKLVWVGDPVPEGWIDFRKLiknaspDFERPTANSYPcgediLLVYFSSGTTGMPKMVEHDFTYP 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  147 ANRLAADIEQYDLTARDVFLYKAPITFDVSV-REIFLPIAIGATLVIAEPGRHgDPVHLADLIRRHGVTVIHFVPAMlaa 225
Cdd:cd05970    211 LGHIVTAKYWQNVREGGLHLTVADTGWGKAVwGKIYGQWIAGAAVFVYDYDKF-DPKALLEKLSKYGVTTFCAPPTI--- 286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  226 FNEVLGAGVG--ELTSLRLIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEasIVVTIHRVT-QDDRVIPIGTPTRRVS 302
Cdd:cd05970    287 YRFLIREDLSryDLSSLRYCTTAGEALNPEVFNTFK-EKTGIKLMEGFGQTE--TTLTIATFPwMEPKPGSMGKPAPGYE 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  303 ARVLDAALREVPIGVPGELYLG-----GVQLARGYAGRPDLTAERFvADPFgepgarlYRTGDRARWNRDGEIEYLGRTD 377
Cdd:cd05970    364 IDLIDREGRSCEAGEEGEIVIRtskgkPVGLFGGYYKDAEKTAEVW-HDGY-------YHTGDAAWMDEDGYLWFVGRTD 435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  378 FQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLV--------GYLAPADVD---VDTVAATTAellpEYMRP 446
Cdd:cd05970    436 DLIKSSGYRIGPFEVESALIQHPAVLECAVTGVPDPIRGQVVkativlakGYEPSEELKkelQDHVKKVTA----PYKYP 511

                          490
                   ....*....|....*....
gi 1827387616  447 SAWVRLDAMPLSRSGKVDR 465
Cdd:cd05970    512 RIVEFVDELPKTISGKIRR 530

PRK04319

acetyl-CoA synthetase; Provisional

76-468

5.16e-14

acetyl-CoA synthetase; Provisional

Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 78.01 E-value: 5.16e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   76 VVVTSDgEAEARSRFDDIVDV-HVLDISSPGDA-----DLDE------EEF-AGPTRPANAAFTLFTSGSTGRPKAVVIT 142
Cdd:PRK04319   148 VLITTP-ALLERKPADDLPSLkHVLLVGEDVEEgpgtlDFNAlmeqasDEFdIEWTDREDGAILHYTSGSTGKPKGVLHV 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  143 HRgianrlaADIEQY-------DLTARDVFLYKA-PITFDVSVREIFLPIAIGATLVIAEpGRHgDPVHLADLIRRHGVT 214
Cdd:PRK04319   227 HN-------AMLQHYqtgkyvlDLHEDDVYWCTAdPGWVTGTSYGIFAPWLNGATNVIDG-GRF-SPERWYRILEDYKVT 297

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  215 VIHFVPamlAAFNEVLGAGVG-----ELTSLRLIQTGGEALTPPVARDLMvRLPGTRLQNQYGPAEASIVVTIHRVTQDD 289
Cdd:PRK04319   298 VWYTAP---TAIRMLMGAGDDlvkkyDLSSLRHILSVGEPLNPEVVRWGM-KVFGLPIHDNWWMTETGGIMIANYPAMDI 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  290 RVIPIGTPTRRVSARVLDAALREVPIGVPGELYL--GGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRD 367
Cdd:PRK04319   374 KPGSMGKPLPGIEAAIVDDQGNELPPNRMGNLAIkkGWPSMMRGIWNNPEKYESYFAGD--------WYVSGDSAYMDED 445

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  368 GEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPggQQLVGYLAPADVDVDTVAATTAELLPEYMrps 447
Cdd:PRK04319   446 GYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAV--AEAGVIGKP--DPVRGEIIKAFVALRPGYEPSEELKEEIR--- 518

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1827387616  448 AWVR--------------LDAMPLSRSGKVDRRLL 468
Cdd:PRK04319   519 GFVKkglgahaapreiefKDKLPKTRSGKIMRRVL 553

PRK07768

long-chain-fatty-acid--CoA ligase; Validated

4-402

6.03e-14

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 77.73 E-value: 6.03e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLP-VDRARYMVRTA------GVRLV 76
Cdd:PRK07768    33 GEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRGASLTMLHQPTPrTDLAVWAEDTLrvigmiGAKAV 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   77 VVTSDGEAEARSRFDDIVDVHVLdisspgdADLDEEEFAGP--TRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADI 154
Cdd:PRK07768   113 VVGEPFLAAAPVLEEKGIRVLTV-------ADLLAADPIDPveTGEDDLALMQLTSGSTGSPKAVQITHGNLYANAEAMF 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  155 E--QYDLtARDVFLYKAPITFDVS-VREIFLPIAIGATLVIAEPGRH-GDPVHLADLIRRHGVTVI---HFVPAMLAafn 227
Cdd:PRK07768   186 VaaEFDV-ETDVMVSWLPLFHDMGmVGFLTVPMYFGAELVKVTPMDFlRDPLLWAELISKYRGTMTaapNFAYALLA--- 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  228 EVLGAGVGE----LTSLRLIQTGGEALTPPVARDLMVR-----LPGTRLQNQYGPAEASIVVTIHRV------------- 285
Cdd:PRK07768   262 RRLRRQAKPgafdLSSLRFALNGAEPIDPADVEDLLDAgarfgLRPEAILPAYGMAEATLAVSFSPCgaglvvdevdadl 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  286 -TQDDRVIP-----------IGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYagrpdLTAERFVA--DPFGep 351
Cdd:PRK07768   342 lAALRRAVPatkgntrrlatLGPPLPGLEVRVVDEDGQVLPPRGVGVIELRGESVTPGY-----LTMDGFIPaqDADG-- 414

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616  352 garLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGV 402
Cdd:PRK07768   415 ---WLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIERAAARVEGV 462

Firefly_Luc

cd17642

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...

2555-3061

6.33e-14

Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 77.57 E-value: 6.33e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2555 PVTggPATDPVTLAELFRAAARRA--PDHVAVVDG-AGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLT 2631
Cdd:cd17642      7 PFY--PLEDGTAGEQLHKAMKRYAsvPGTIAFTDAhTGVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFFL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2632 AIWAVAKTGGAYVPIDPDY-------------PA---------ERVASMIEDSGAVLGLSVLASG-DLPG-QEFE-WMRL 2686
Cdd:cd17642     85 PVIAGLFIGVGVAPTNDIYnereldhslniskPTivfcskkglQKVLNVQKKLKIIKTIIILDSKeDYKGyQCLYtFITQ 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2687 DDDSVAAEIAAVPagPITDAERlgevtaaNLAYVIYTSGSTGRPKGVAVTHSGL-ANFARQESDRLNAGDNP-VVLGFAS 2764
Cdd:cd17642    165 NLPPGFNEYDFKP--PSFDRDE-------QVALIMNSSGSTGLPKGVQLTHKNIvARFSHARDPIFGNQIIPdTAILTVI 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2765 PSFDASVLEYLLATVNEG---TLAYRPSEavggEVLERFIAEHGATHTFLTPSVLS------TMDPTAVPSLRVIAAGGE 2835
Cdd:cd17642    236 PFHHGFGMFTTLGYLICGfrvVLMYKFEE----ELFLRSLQDYKVQSALLVPTLFAffakstLVDKYDLSNLHEIASGGA 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2836 AVPQPIVDRWAPATELHNL---YGPTETTIGITISSA--MRPGDpvrLGGPIGGVDLMVLD-ERLRPVPVGMPGELYVAG 2909
Cdd:cd17642    312 PLSKEVGEAVAKRFKLPGIrqgYGLTETTSAILITPEgdDKPGA---VGKVVPFFYAKVVDlDTGKTLGPNERGELCVKG 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2910 GALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWtpDTDTGGLTLEytgRSDDQVKLRGLRIELGEIEAVLAEHD 2989
Cdd:cd17642    389 PMIMKGYVNNPEATKALIDKDGW-------LHSGDIAYY--DEDGHFFIVD---RLKSLIKYKGYQVPPAELESILLQHP 456

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 2990 AVESAVVLGVGGSVATALAAYIVPVDGAVEVSE---LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPE 3061
Cdd:cd17642    457 KIFDAGVAGIPDEDAGELPAAVVVLEAGKTMTEkevMDYVASQVSTAKRLRGGVKFVDEVPKGLTGKIDRRKIRE 531

LC_FACS_euk1

cd17639

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...

2717-3034

6.98e-14

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.

Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 77.26 E-value: 6.98e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2717 LAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLN--AGDNPVVLGFAsPSfdASVLEYLL--------ATVNEG---T 2783
Cdd:cd17639     90 LACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPelLGPDDRYLAYL-PL--AHIFELAAenvclyrgGTIGYGsprT 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2784 L-------------AYRPSEAVG-GEVLER----------------------------FIAEHGATHTFLTPSVLSTMDP 2821
Cdd:cd17639    167 LtdkskrgckgdltEFKPTLMVGvPAIWDTirkgvlaklnpmgglkrtlfwtayqsklKALKEGPGTPLLDELVFKKVRA 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2822 TAVPSLRVIAAGGEAVpqpivdrwAPAT-ELHNL--------YGPTETTIGITISsamRPGD--PVRLGGPIGGVDLMVL 2890
Cdd:cd17639    247 ALGGRLRYMLSGGAPL--------SADTqEFLNIvlcpviqgYGLTETCAGGTVQ---DPGDleTGRVGPPLPCCEIKLV 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2891 D-ERLRPVP-VGMP-GELYVAGGALSRGYLDRSGLTAERFTanpygtaGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDD 2967
Cdd:cd17639    316 DwEEGGYSTdKPPPrGEILIRGPNVFKGYYKNPEKTKEAFD-------GDGWFHTGDIGEFHPDG-----TLKIIDRKKD 383

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 2968 QVKLR-GLRIELGEIEAVLAEHDAVESAVVLGVggSVATALAAYIVPVDGAVEV-SELKAFAGGRLPAY 3034
Cdd:cd17639    384 LVKLQnGEYIALEKLESIYRSNPLVNNICVYAD--PDKSYPVAIVVPNEKHLTKlAEKHGVINSEWEEL 450

PRK08751

long-chain fatty acid--CoA ligase;

120-468

7.32e-14

long-chain fatty acid--CoA ligase;

Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 77.61 E-value: 7.32e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  120 PANAAFTLFTSGSTGRPKAVVITHRG-IANRLAAdiEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEPGRH 198
Cdd:PRK08751   207 PDDIAFLQYTGGTTGVAKGAMLTHRNlVANMQQA--HQWLAGTGKLEEGCEVVITALPLYHIFALTANGLVFMKIGGCNH 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  199 --GDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGA-GVGEL--TSLRLIQTGGEALTPPVARDLMvRLPGTRLQNQYGP 273
Cdd:PRK08751   285 liSNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTpGFDQIdfSSLKMTLGGGMAVQRSVAERWK-QVTGLTLVEAYGL 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  274 AEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepga 353
Cdd:PRK08751   364 TETSPAACINPLTLKEYNGSIGLPIPSTDACIKDDAGTVLAIGEIGELCIKGPQVMKGYWKRPEETAKVMDADGW----- 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  354 rlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLH-AAAAVVDGPGGQQLVGYLAPAD--VDVD 430
Cdd:PRK08751   439 --LHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLEvAAVGVPDEKSGEIVKVVIVKKDpaLTAE 516

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1827387616  431 TVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK08751   517 DVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRREL 554

PP-binding

pfam00550

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...

3078-3139

9.38e-14

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.

Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 67.97 E-value: 9.38e-14

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 3078 RTIADVAAGVLNIDAGLVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRA 3139
Cdd:pfam00550    1 ERLRELLAEVLGVPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62

PRK07867

acyl-CoA synthetase; Validated

28-468

1.03e-13

acyl-CoA synthetase; Validated

Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 77.03 E-value: 1.03e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   28 VGIQIDRSVEQVVAIHAVAMAGGHFVPLDeqlPVDRARYMVRT---AGVRLVVVtsdgEAEARSRFDDIV-DVHVLDISS 103
Cdd:PRK07867    57 VGVLLDNTPEFSLLLGAAALSGIVPVGLN---PTRRGAALARDiahADCQLVLT----ESAHAELLDGLDpGVRVINVDS 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  104 PGDADL-----DEEEFAGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVR 178
Cdd:PRK07867   130 PAWADElaahrDAEPPFRVADPDDLFMLIFTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDDVCYVSMPLFHSNAVM 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  179 EIFLP-IAIGATLVIaePGRHGDPVHLADlIRRHGVTVIHFVPAMLAAfneVLGAgvGEL-----TSLRlIQTGGEALTP 252
Cdd:PRK07867   210 AGWAVaLAAGASIAL--RRKFSASGFLPD-VRRYGATYANYVGKPLSY---VLAT--PERpddadNPLR-IVYGNEGAPG 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  253 PVARdlMVRLPGTRLQNQYGPAEASIVVT---------IHRVTQDDRVIPIGTPTRRVSArVLDAALREVPIGVPGELY- 322
Cdd:PRK07867   281 DIAR--FARRFGCVVVDGFGSTEGGVAITrtpdtppgaLGPLPPGVAIVDPDTGTECPPA-EDADGRLLNADEAIGELVn 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  323 LGGVQLARGYAGRPDLTAERFVADpfgepgarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGV 402
Cdd:PRK07867   358 TAGPGGFEGYYNDPEADAERMRGG--------VYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDA 429

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  403 LHAAA-AVVDGPGGQQLVGYLAPADvDVDTVAATTAELLPEY--MRPSAW---VRL-DAMPLSRSGKVDRRLL 468
Cdd:PRK07867   430 TEVAVyAVPDPVVGDQVMAALVLAP-GAKFDPDAFAEFLAAQpdLGPKQWpsyVRVcAELPRTATFKVLKRQL 501

PRK08162

acyl-CoA synthetase; Validated

2574-3068

1.12e-13

acyl-CoA synthetase; Validated

Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 76.91 E-value: 1.12e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2574 AARRAPDHVAVVDGAgARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAE 2653
Cdd:PRK08162    27 AAEVYPDRPAVIHGD-RRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPMAGAVLNTLNTRLDAA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2654 RVASMIEDSGAVLGLSVLASGDLPGQEFEWM-RLDDDSVAAEIAAVPAGPI---TDAERLGEVTAANLAYVI-------- 2721
Cdd:PRK08162   106 SIAFMLRHGEAKVLIVDTEFAEVAREALALLpGPKPLVIDVDDPEYPGGRFigaLDYEAFLASGDPDFAWTLpadewdai 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2722 ---YTSGSTGRPKGVAVTHSGLAnfarqesdrLNAGDN---------PVVL---------GFASPSFDAsvleyLLATVN 2780
Cdd:PRK08162   186 alnYTSGTTGNPKGVVYHHRGAY---------LNALSNilawgmpkhPVYLwtlpmfhcnGWCFPWTVA-----ARAGTN 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2781 EGTLAYRPseavgGEVLErFIAEHGATHTFLTPSVLSTM-----DPTAVPSLRVIAAGGEAVPQPIVDRWAPAT--ELHN 2853
Cdd:PRK08162   252 VCLRKVDP-----KLIFD-LIREHGVTHYCGAPIVLSALinapaEWRAGIDHPVHAMVAGAAPPAAVIAKMEEIgfDLTH 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2854 LYGPTETTIGITIS------SAMRPGDPVRLGGPiGGV------DLMVLD-ERLRPVPVG--MPGELYVAGGALSRGYLD 2918
Cdd:PRK08162   326 VYGLTETYGPATVCawqpewDALPLDERAQLKAR-QGVryplqeGVTVLDpDTMQPVPADgeTIGEIMFRGNIVMKGYLK 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2919 RSGLTAERFtanpygtAGQrMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVlg 2998
Cdd:PRK08162   405 NPKATEEAF-------AGG-WFHTGDLAVLHPDG-----YIKIKDRSKDIIISGGENISSIEVEDVLYRHPAVLVAAV-- 469

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 2999 vggsVATALA-------AYIVPVDGA-VEVSELKAFAGGRLPAYMVPSSFtVIDELPLTPVGKLDKRALPEPVLEAGE 3068
Cdd:PRK08162   470 ----VAKPDPkwgevpcAFVELKDGAsATEEEIIAHCREHLAGFKVPKAV-VFGELPKTSTGKIQKFVLREQAKSLKA 542

PLN02330

4-coumarate--CoA ligase-like 1

1035-1532

1.21e-13

4-coumarate--CoA ligase-like 1

Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 76.94 E-value: 1.21e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1035 EAGTLID-VLAQRDLDPDHPALI--CDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGA 1111
Cdd:PLN02330    26 DKLTLPDfVLQDAELYADKVAFVeaVTGKAVTYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMAAGG 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1112 AYVPVDPAYPADRIAYMLEDSGATVGITDASTRAR----------LGESSCE----WVDLADleaeaeSGDDITDTERNG 1177
Cdd:PLN02330   106 VFSGANPTALESEIKKQAEAAGAKLIVTNDTNYGKvkglglpvivLGEEKIEgavnWKELLE------AADRAGDTSDNE 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1178 SVRLTNLAYLIYTSGSTGRPKAVGVSHTGIVdfVNSLAKITTGTPEdepdtRILHVASPSFdasmfemawaIPAGHTLVI 1257
Cdd:PLN02330   180 EILQTDLCALPFSSGTTGISKGVMLTHRNLV--ANLCSSLFSVGPE-----MIGQVVTLGL----------IPFFHIYGI 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1258 ApqadfaGDALATVLERDEVTDM---------------------IITPSVLATV-DPERAQY------VRNLATGGEACP 1309
Cdd:PLN02330   243 T------GICCATLRNKGKVVVMsrfelrtflnalitqevsfapIVPPIILNLVkNPIVEEFdlsklkLQAIMTAAAPLA 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1310 PELVERWSER--GRRIFNCYGPTEATVWAtrsrMTAGKPV---------TIGKPVDGFTVRVLD---GRlhEVPQGVVGE 1375
Cdd:PLN02330   317 PELLTAFEAKfpGVQVQEAYGLTEHSCIT----LTHGDPEkghgiakknSVGFILPNLEVKFIDpdtGR--SLPKNTPGE 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1376 LYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQP 1455
Cdd:PLN02330   391 LCVRSQCVMQGYYNNKEETDRTIDEDGW-------LHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHP 463

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1456 GVAQSVVVGVESTRGGrkhtEV-VAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALPE 1532
Cdd:PLN02330   464 SVEDAAVVPLPDEEAG----EIpAACVVINPKAKESEEDILNFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRLLKE 537

FADD10

cd17635

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...

1187-1527

1.29e-13

Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 74.99 E-value: 1.29e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1187 LIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDEPDTRILHVaspSFDASMFEMAWAIPAGHTLVIApqADFAG- 1265
Cdd:cd17635      6 VIFTSGTTGEPKAVLLANKTFFAVPDILQKEGLNWVVGDVTYLPLPA---THIGGLWWILTCLIHGGLCVTG--GENTTy 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1266 DALATVLERDEVTDMIITPSVLATVDPERA---QYVR--NLATGGEACPPELVERWSE--RGRRIFNCYGPTEAT----V 1334
Cdd:cd17635     81 KSLFKILTTNAVTTTCLVPTLLSKLVSELKsanATVPslRLIGYGGSRAIAADVRFIEatGLTNTAQVYGLSETGtalcL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1335 WATRSRMTAGkpvTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmyATG 1414
Cdd:cd17635    161 PTDDDSIEIN---AVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLIDGWV--------NTG 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1415 DLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtEVVAYLVAKPGATIDSA-- 1492
Cdd:cd17635    230 DLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFG----ELVGLAVVASAELDENAir 305

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1827387616 1493 AVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd17635    306 ALKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340

PRK08974

long-chain-fatty-acid--CoA ligase FadD;

124-475

1.29e-13

long-chain-fatty-acid--CoA ligase FadD;

Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 76.63 E-value: 1.29e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  124 AFTLFTSGSTGRPKAVVITHRG-IANRLAAD-------IEQYDLTARDVFLYKapiTFDVSVrEIFLPIAIGAT-LVIAE 194
Cdd:PRK08974   209 AFLQYTGGTTGVAKGAMLTHRNmLANLEQAKaaygpllHPGKELVVTALPLYH---IFALTV-NCLLFIELGGQnLLITN 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  195 PgRhgDPVHLADLIRRHGVTVIHFVPAMLAA------FNEVlgagvgELTSLRLIQTGGEALTPPVArDLMVRLPGTRLQ 268
Cdd:PRK08974   285 P-R--DIPGFVKELKKYPFTAITGVNTLFNAllnneeFQEL------DFSSLKLSVGGGMAVQQAVA-ERWVKLTGQYLL 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  269 NQYGPAEASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAErFVADPF 348
Cdd:PRK08974   355 EGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVPPGEPGELWVKGPQVMLGYWQRPEATDE-VIKDGW 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  349 gepgarlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAPADV 427
Cdd:PRK08974   434 -------LATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKVLEVAAvGVPSEVSGEAVKIFVVKKDP 506

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1827387616  428 DV--DTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEIAP 475
Cdd:PRK08974   507 SLteEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAK 556

ACS

cd05966

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...

2591-3059

1.40e-13

Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 76.83 E-value: 1.40e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2591 RLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGA------ 2664
Cdd:cd05966     84 TITYRELLREVCRFANVLKSLGVKKGDRVAIYMPMIPELVIAMLACARIGAVHSVVFAGFSAESLADRINDAQCklvita 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2665 --------VLGLSVLASGDL----------------------PGQEFEWmrldDDSVAAEIAAVPAGPItDAErlgevta 2714
Cdd:cd05966    164 dggyrggkVIPLKEIVDEALekcpsvekvlvvkrtggevpmtEGRDLWW----HDLMAKQSPECEPEWM-DSE------- 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2715 aNLAYVIYTSGSTGRPKGVAVTHSGLANFAR---------QESDRL-NAGD------------NPVVLGfaspsfdASVL 2772
Cdd:cd05966    232 -DPLFILYTSGSTGKPKGVVHTTGGYLLYAAttfkyvfdyHPDDIYwCTADigwitghsyivyGPLANG-------ATTV 303

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2773 EYllatvnEGTLAYrPSEAVGGEVLERfiaeHGATHtFLTPsvlstmdPTAV----------------PSLRVIAAGGEA 2836
Cdd:cd05966    304 MF------EGTPTY-PDPGRYWDIVEK----HKVTI-FYTA-------PTAIralmkfgdewvkkhdlSSLRVLGSVGEP 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2837 V-PQ--------------PIVDRWapatelhnlyGPTETTiGITISS-----AMRPGDPVRlggPIGGVDLMVLDERLRP 2896
Cdd:cd05966    365 InPEawmwyyevigkercPIVDTW----------WQTETG-GIMITPlpgatPLKPGSATR---PFFGIEPAILDEEGNE 430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2897 VPVGMPGELYVAG---GALSRGYLDRsgltaERFTaNPYGTAGQRMYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKLRG 2973
Cdd:cd05966    431 VEGEVEGYLVIKRpwpGMARTIYGDH-----ERYE-DTYFSKFPGYYFTGDGARRDED---GYYWI--TGRVDDVINVSG 499

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2974 LRIELGEIEAVLAEHDAV-ESAVVlGVGGSVAT-ALAAYIVPVDGAVE----VSELKAFAGGRLPAYMVPSSFTVIDELP 3047
Cdd:cd05966    500 HRLGTAEVESALVAHPAVaEAAVV-GRPHDIKGeAIYAFVTLKDGEEPsdelRKELRKHVRKEIGPIATPDKIQFVPGLP 578

                          570
                   ....*....|..
gi 1827387616 3048 LTPVGKLDKRAL 3059
Cdd:cd05966    579 KTRSGKIMRRIL 590

AMP-binding_C

pfam13193

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...

1446-1524

1.47e-13

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.

Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 67.95 E-value: 1.47e-13

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1446 EIEAVLDAQPGVAQSVVVGVESTRGGRkhtEVVAYLVAKPGATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGK 1524
Cdd:pfam13193    1 EVESALVSHPAVAEAAVVGVPDELKGE---APVAFVVLKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76

LC_FACS_bac

cd05932

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...

2592-3033

1.82e-13

Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 75.97 E-value: 1.82e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAvlglSVL 2671
Cdd:cd05932      7 FTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSES----KAL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 ASGDLpgqefewmrlddDSVAAEIAAVPAGPIT------DAER--------------LGEVT---AANLAYVIYTSGSTG 2728
Cdd:cd05932     83 FVGKL------------DDWKAMAPGVPEGLISislpppSAANcqyqwddliaqhppLEERPtrfPEQLATLIYTSGTTG 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2729 RPKGVAVTHSGLANFARQESDRLNAGDNPvvlgfaspsfdaSVLEYL-LATVNEGTLAYRPSEAVG-----GEVLERFIA 2802
Cdd:cd05932    151 QPKGVMLTFGSFAWAAQAGIEHIGTEEND------------RMLSYLpLAHVTERVFVEGGSLYGGvlvafAESLDTFVE 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2803 E---HGATHTFLTP--------SVLSTMDPTAVPSL-----------------------RVIAAGGEAVPQPIVDrW--A 2846
Cdd:cd05932    219 DvqrARPTLFFSVPrlwtkfqqGVQDKIPQQKLNLLlkipvvnslvkrkvlkglgldqcRLAGCGSAPVPPALLE-WyrS 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2847 PATELHNLYGPTETtigITISSAMRPGDPVR--LGGPIGGVDLMVLDErlrpvpvgmpGELYVAGGALSRGYLDRSGLTA 2924
Cdd:cd05932    298 LGLNILEAYGMTEN---FAYSHLNYPGRDKIgtVGNAGPGVEVRISED----------GEILVRSPALMMGYYKDPEATA 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2925 ERFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVKL-RGLRIELGEIEAVLAEHDAVESAVVLGVGGSV 3003
Cdd:cd05932    365 EAFTADGF-------LRTGDKGELDAD---GNLTI--TGRVKDIFKTsKGKYVAPAPIENKLAEHDRVEMVCVIGSGLPA 432

                          490       500       510
                   ....*....|....*....|....*....|
gi 1827387616 3004 ATALAayivpVDGAVEVSELKAFAGGRLPA 3033
Cdd:cd05932    433 PLALV-----VLSEEARLRADAFARAELEA 457

FATP_FACS

cd05940

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...

4-446

1.92e-13

Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 75.47 E-value: 1.92e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGghfvpldeqlpvdrarymvrtAGVRLVVVTSDGE 83
Cdd:cd05940      7 AELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIG---------------------AVAALINYNLRGE 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AEArsrfddivdvHVLDISSPGDADLDeeefagptrpanAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd05940     66 SLA----------HCLNVSSAKHLVVD------------AALYIYTSGTTGLPKAAIISHRRAWRGGAFFAGSGGALPSD 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPITFDVSVreIFLP---IAIGATLVIaepGRHGDPVHLADLIRRHGVTVIHFVpamlaafnevlgagvGELT-- 238
Cdd:cd05940    124 VLYTCLPLYHSTAL--IVGWsacLASGATLVI---RKKFSASNFWDDIRKYQATIFQYI---------------GELCry 183

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 -------------SLRLIQtgGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVT--------------IHRVTQDDRV 291
Cdd:cd05940    184 llnqppkpterkhKVRMIF--GNGLRPDIWEEFKERFGVPRIAEFYAATEGNSGFInffgkpgaigrnpsLLRKVAPLAL 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  292 IPI----GTPTRRVSARVldaalREVPIGVPGEL--YLGGVQLARGYAGrPDLTAERFVADPFgEPGARLYRTGDRARWN 365
Cdd:cd05940    262 VKYdlesGEPIRDAEGRC-----IKVPRGEPGLLisRINPLEPFDGYTD-PAATEKKILRDVF-KKGDAWFNTGDLMRLD 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  366 RDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVV-----DGPGGQQLVGYLAPADVDVDTVAATTAELL 440
Cdd:cd05940    335 GEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVqvpgtDGRAGMAAIVLQPNEEFDLSALAAHLEKNL 414


                   ....*.
gi 1827387616  441 PEYMRP 446
Cdd:cd05940    415 PGYARP 420

LC_FACS_like

cd17640

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...

4-400

2.05e-13

Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 75.86 E-value: 2.05e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGe 83
Cdd:cd17640      9 KDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVALVVENDS- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 aearsrfDDIvdvhvldisspgdadldeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARD 163
Cdd:cd17640     88 -------DDL------------------------------ATIIYTSGTTGNPKGVMLTHANLLHQIRSLSDIVPPQPGD 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  164 VFLYKAPI--TFDVSVrEIFLpIAIGATLViaepgrHGDPVHLADLIRRHGVTVIHFVPAMLAAFNE------------- 228
Cdd:cd17640    131 RFLSILPIwhSYERSA-EYFI-FACGCSQA------YTSIRTLKDDLKRVKPHYIVSVPRLWESLYSgiqkqvsksspik 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  229 --VLGAGV--GELtslRLIQTGGEALTPPVarDLMVRLPGTRLQNQYGPAEASIVVTIHRVtqdDRVI--PIGTPTRRVS 302
Cdd:cd17640    203 qfLFLFFLsgGIF---KFGISGGGALPPHV--DTFFEAIGIEVLNGYGLTETSPVVSARRL---KCNVrgSVGRPLPGTE 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  303 ARVLDAALREV-PIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRT-DFQV 380
Cdd:cd17640    275 IKIVDPEGNVVlPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSDGW-------FNTGDLGWLTCGGELVLTGRAkDTIV 347

                          410       420
                   ....*....|....*....|
gi 1827387616  381 KLRGQRLELGEVEAALAAAP 400
Cdd:cd17640    348 LSNGENVEPQPIEEALMRSP 367

PLN02860

o-succinylbenzoate-CoA ligase

2570-3066

2.06e-13

o-succinylbenzoate-CoA ligase

Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 75.99 E-value: 2.06e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2570 LFRAAARRApdHVAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPD 2649
Cdd:PLN02860    13 LTRLATLRG--NAVVTISGNRRRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYR 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2650 YPAERVASMIE---------DSGAVLGLSVLASGDLPgqEFEW-MRLDDDSVAAEIAAVPAGPITDAERLGEVTA----- 2714
Cdd:PLN02860    91 WSFEEAKSAMLlvrpvmlvtDETCSSWYEELQNDRLP--SLMWqVFLESPSSSVFIFLNSFLTTEMLKQRALGTTeldya 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2715 ---ANLAYVIYTSGSTGRPKGVAVTHSG-----LANFA---RQESD-------------------RLNAGDNPVVLgfas 2764
Cdd:PLN02860   169 wapDDAVLICFTSGTTGRPKGVTISHSAlivqsLAKIAivgYGEDDvylhtaplchigglssalaMLMVGACHVLL---- 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2765 PSFDASVleyllatvnegtlayrpseavggeVLErFIAEHGATHTFLTPSVL--------STMDPTAVPSLRVIAAGGEA 2836
Cdd:PLN02860   245 PKFDAKA------------------------ALQ-AIKQHNVTSMITVPAMMadlisltrKSMTWKVFPSVRKILNGGGS 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2837 VPQPIVD---RWAPATELHNLYGPTET----------------------TIGITISSAMRPGDPVRLGGPIGGVDLMV-L 2890
Cdd:PLN02860   300 LSSRLLPdakKLFPNAKLFSAYGMTEAcssltfmtlhdptlespkqtlqTVNQTKSSSVHQPQGVCVGKPAPHVELKIgL 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2891 DERLRpvpvgmPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDvVRWTpdTDTGGLTLeyTGRSDDQVK 2970
Cdd:PLN02860   380 DESSR------VGRILTRGPHVMLGYWGQNSETASVLSNDGW-------LDTGD-IGWI--DKAGNLWL--IGRSNDRIK 441

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2971 LRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPV-DGAVEVSELKAFAGG----------------RLPA 3033
Cdd:PLN02860   442 TGGENVYPEEVEAVLSQHPGVASVVVVGVPDSRLTEMVVACVRLrDGWIWSDNEKENAKKnltlssetlrhhcrekNLSR 521

                          570       580       590
                   ....*....|....*....|....*....|....
gi 1827387616 3034 YMVPSSFTVI-DELPLTPVGKLDKRALPEPVLEA 3066
Cdd:PLN02860   522 FKIPKLFVQWrKPFPLTTTGKIRRDEVRREVLSH 555

PRK00174

acetyl-CoA synthetase; Provisional

125-468

2.23e-13

acetyl-CoA synthetase; Provisional

Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 76.33 E-value: 2.23e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  125 FTLFTSGSTGRPKAVVITHRGIANRLAadieqydLTARDVFLYKAPITF----DVS-------VreIFLPIAIGATLVIA 193
Cdd:PRK00174   249 FILYTSGSTGKPKGVLHTTGGYLVYAA-------MTMKYVFDYKDGDVYwctaDVGwvtghsyI--VYGPLANGATTLMF 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  194 E-------PGRHGDpvhladLIRRHGVTVIHFVPAMLAAFnevLGAGVGE-----LTSLRLIQTGGEALTPP-------- 253
Cdd:PRK00174   320 EgvpnypdPGRFWE------VIDKHKVTIFYTAPTAIRAL---MKEGDEHpkkydLSSLRLLGSVGEPINPEawewyykv 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  254 VARDlmvRLPgtrlqnqygpaeasIVVTI-------HRVTQDDRVIPI--GTPTRR---VSARVLDAALREVPIGVPGEL 321
Cdd:PRK00174   391 VGGE---RCP--------------IVDTWwqtetggIMITPLPGATPLkpGSATRPlpgIQPAVVDEEGNPLEGGEGGNL 453

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  322 YL-----GgvqLARGYAGRPdltaERFVADPFGE-PGarLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAA 395
Cdd:PRK00174   454 VIkdpwpG---MMRTIYGDH----ERFVKTYFSTfKG--MYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESA 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  396 LAAAPGVlhAAAAVVDGP---GGQQLVGYlapadVDVDTVAATTAELLPEyMRpsAWVR--------------LDAMPLS 458
Cdd:PRK00174   525 LVAHPKV--AEAAVVGRPddiKGQGIYAF-----VTLKGGEEPSDELRKE-LR--NWVRkeigpiakpdviqfAPGLPKT 594

                          410
                   ....*....|
gi 1827387616  459 RSGKVDRRLL 468
Cdd:PRK00174   595 RSGKIMRRIL 604

PRK06814

acyl-[ACP]--phospholipid O-acyltransferase;

119-464

2.40e-13

acyl-[ACP]--phospholipid O-acyltransferase;

Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 76.54 E-value: 2.40e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  119 RPANAAFTLFTSGSTGRPKAVVITHRGI-ANR--LAADIeqyDLTARDvflykapITFDVsvreifLPI--AIGATLVIA 193
Cdd:PRK06814   791 DPDDPAVILFTSGSEGTPKGVVLSHRNLlANRaqVAARI---DFSPED-------KVFNA------LPVfhSFGLTGGLV 854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  194 EPGRHGDPVHL----------ADLIRRHGVTVIHFVPAMLAAFNEVlgAGVGELTSLRLIQTGGEALTPPVARDLMVRLp 263
Cdd:PRK06814   855 LPLLSGVKVFLypsplhyriiPELIYDTNATILFGTDTFLNGYARY--AHPYDFRSLRYVFAGAEKVKEETRQTWMEKF- 931

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  264 GTRLQNQYGPAEASivvtihrvtqddRVIPIGTPTRRVSARV------LDAALREVPiGVP--GELYLGGVQLARGYagr 335
Cdd:PRK06814   932 GIRILEGYGVTETA------------PVIALNTPMHNKAGTVgrllpgIEYRLEPVP-GIDegGRLFVRGPNVMLGY--- 995

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  336 pdLTAER-FVADPfgePGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAA-PGVLHAAAAVVDGP 413
Cdd:PRK06814   996 --LRAENpGVLEP---PADGWYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEELAAELwPDALHAAVSIPDAR 1070

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  414 GGQQLVGYLAPADVDVDTVAA-TTAELLPEYMRPSAWVRLDAMPLSRSGKVD 464
Cdd:PRK06814  1071 KGERIILLTTASDATRAAFLAhAKAAGASELMVPAEIITIDEIPLLGTGKID 1122

PRK13390

acyl-CoA synthetase; Provisional

1-468

3.08e-13

acyl-CoA synthetase; Provisional

Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 75.43 E-value: 3.08e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTS 80
Cdd:PRK13390    25 VSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAPEADYIVGDSGARVLVASA 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   81 ---------DGEAEARSRFDDIVDvhvldisspGDADLDEE-EFAGP--TRPANAAFTLFTSGSTGRPKavvithrGIAN 148
Cdd:PRK13390   105 aldglaakvGADLPLRLSFGGEID---------GFGSFEAAlAGAGPrlTEQPCGAVMLYSSGTTGFPK-------GIQP 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  149 RLAA-DIEQ------------YDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepgRHGDPVHLADLIRRHGVTV 215
Cdd:PRK13390   169 DLPGrDVDApgdpivaiarafYDISESDIYYSSAPIYHAAPLRWCSMVHALGGTVVLA---KRFDAQATLGHVERYRITV 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  216 IHFVPAMLAAFNEvLGAGVG---ELTSLRLIqTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIhrvTQDDRVI 292
Cdd:PRK13390   246 TQMVPTMFVRLLK-LDADVRtryDVSSLRAV-IHAAAPCPVDVKHAMIDWLGPIVYEYYSSTEAHGMTFI---DSPDWLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  293 PIGTPTRRV--SARVLDAALREVPIGVPGELYLGGVQLARGYAGRPDLTAE-RFVADPFgepgarLYRTGDRARWNRDGE 369
Cdd:PRK13390   321 HPGSVGRSVlgDLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKTAAaQHPAHPF------WTTVGDLGSVDEDGY 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  370 IEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGP--GGQ-----QLVGYLAPADVDVDTVAATTAELLPE 442
Cdd:PRK13390   395 LYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPemGEQvkaviQLVEGIRGSDELARELIDYTRSRIAH 474

                          490       500
                   ....*....|....*....|....*.
gi 1827387616  443 YMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK13390   475 YKAPRSVEFVDELPRTPTGKLVKGLL 500

AcpA

COG3433

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...

2861-3144

3.78e-13

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442659 [Multi-domain] Cd Length: 295 Bit Score: 72.86 E-value: 3.78e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2861 TIGITISSAMRPGDPVRLGGPIGGVDLMVLdeRLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRmY 2940
Cdd:COG3433      1 IAIATPPPAPPTPDEPPPVIPPAIVQARAL--LLIVDLQGYFGGFGGEGGLLGAGLLLRIRLLAAAARAPFIPVPYPA-Q 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2941 RTGDVVRWTPDTDTGGLTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEV 3020
Cdd:COG3433     78 PGRQADDLRLLLRRGLGPGGGLERLVQQVVIRAERGEEEELLLVLRAAAVVRVAVLAALRGAGVGLLLIVGAVAALDGLA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3021 SELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALP--EPVLEAGEYVAPATGTERT-----IADVAAGVLNIDAG 3093
Cdd:COG3433    158 AAAALAALDKVPPDVVAASAVVALDALLLLALKVVARAAPalAAAEALLAAASPAPALETAlteeeLRADVAELLGVDPE 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 3094 LVSATSSFFELGGDSLSAARLAARLSdQLGVAVSVRDVFESGSIRALAETV 3144
Cdd:COG3433    238 EIDPDDNLFDLGLDSIRLMQLVERWR-KAGLDVSFADLAEHPTLAAWWALL 287

X-Domain_NRPS

cd19546

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to ...

2141-2535

4.28e-13

Pssm-ID: 380468 [Multi-domain] Cd Length: 440 Bit Score: 74.44 E-value: 4.28e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2141 LSLTGDVDPGRLRSALSELLARQRVLRSGFvrlpSGAAVTVVPAEVTVPWSVIDLRAEDAAslDSRVEEVLATERTNPFD 2220
Cdd:cd19546     33 LRLRGRLDRDALEAALGDVAARHEILRTTF----PGDGGDVHQRILDADAARPELPVVPAT--EEELPALLADRAAHLFD 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2221 MAKPPLIRVVLVEHGDGAE-LVVTNHHLLIDGWSSPLVLADLLSLYatGQTFTGSLPGTS--GRDFADHA-------RAV 2290
Cdd:cd19546    107 LTRETPWRCTLFALSDTEHvLLLVVHRIAADDESLDVLVRDLAAAY--GARREGRAPERAplPLQFADYAlwerellAGE 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2291 ATADVEAG--IAAWREVLAPVtEPTLVAPGHEPSADAPPRDH---QFSIDVKVTERLEALARNNSTTMATVVQFAWAMFL 2365
Cdd:cd19546    185 DDRDSLIGdqIAYWRDALAGA-PDELELPTDRPRPVLPSRRAgavPLRLDAEVHARLMEAAESAGATMFTVVQAALAMLL 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2366 SRLTGTRTVTFAeTVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDHQQIGLPRLVAQTGLP 2445
Cdd:cd19546    264 TRLGAGTDVTVG-TVLPRDDEEGDLEGMVGPFARPLALRTDLSGDPTFRELLGRVREAVREARRHQDVPFERLAELLALP 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2446 ALFDTLAVYE-SFPVNVDSVAGIDASSAGGLK--LVGAKTsDATHYPLNLSAS-RRGAE-----LALKLKYLPTAFAPEQ 2516
Cdd:cd19546    343 PSADRHPVFQvALDVRDDDNDPWDAPELPGLRtsPVPLGT-EAMELDLSLALTeRRNDDgdpdgLDGSLRYAADLFDRAT 421

                          410
                   ....*....|....*....
gi 1827387616 2517 VAVFADVLTGLLGAIADHP 2535
Cdd:cd19546    422 AAALARRLVRVLEQVAADP 440

PRK06060

p-hydroxybenzoic acid--AMP ligase FadD22;

123-468

4.99e-13

p-hydroxybenzoic acid--AMP ligase FadD22;

Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 75.07 E-value: 4.99e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  123 AAFTLFTSGSTGRPKAVVITHRGIANRLAADI-EQYDLTARDVFLYKAPITFDVSV-REIFLPIAIGATLVIAEPgrhgd 200
Cdd:PRK06060   147 LAYATYTSGTTGPPKAAIHRHADPLTFVDAMCrKALRLTPEDTGLCSARMYFAYGLgNSVWFPLATGGSAVINSA----- 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  201 PVH---LADLIRRHGVTVIHFVPAMlaaFNEVLGA-GVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEA 276
Cdd:PRK06060   222 PVTpeaAAILSARFGPSVLYGVPNF---FARVIDScSPDSFRSLRCVVSAGEALELGLAERLMEFFGGIPILDGIGSTEV 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  277 SIVVTIHRVtQDDRVIPIGTPTRRVSARVLDAALREVPIGVPGELYLGGVQLARGYAGRPdltaerfvaDPFGEPGARLy 356
Cdd:PRK06060   299 GQTFVSNRV-DEWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRP---------DSPVANEGWL- 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  357 RTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAA-AAVVDGPGGQQLVGYLAPAD---VDVDTV 432
Cdd:PRK06060   368 DTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAvVAVRESTGASTLQAFLVATSgatIDGSVM 447

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1827387616  433 AATTAELLPE---YMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK06060   448 RDLHRGLLNRlsaFKVPHRFAVVDRLPRTPNGKLVRGAL 486

entE

PRK10946

(2,3-dihydroxybenzoyl)adenylate synthase;

1039-1530

5.17e-13

(2,3-dihydroxybenzoyl)adenylate synthase;

Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 74.64 E-value: 5.17e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1039 LIDVLAqRDLDPDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVgmerSIGSV----LATWGVIKSGAAyv 1114
Cdd:PRK10946    27 LTDILT-RHAASDAIAVICGERQFSYRELNQASDNLACSLRRQGIKPGDTALV----QLGNVaefyITFFALLKLGVA-- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1115 PVDP----------AYpADRI--AYMLEDSGATVGITDASTRARLGESSCEWVDLADLEAEAESGDDITDTERNGSVRLT 1182
Cdd:PRK10946   100 PVNAlfshqrselnAY-ASQIepALLIADRQHALFSDDDFLNTLVAEHSSLRVVLLLNDDGEHSLDDAINHPAEDFTATP 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 N----LAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPedepDTRILhVASPSfdASMFEMA-----WAIPAGH 1253
Cdd:PRK10946   179 SpadeVAFFQLSGGSTGTPKLIPRTHNDYYYSVRRSVEICGFTP----QTRYL-CALPA--AHNYPMSspgalGVFLAGG 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1254 TLVIAPqadfagDALAT----VLERDEVTDMIITPSVL-----ATVDPERAQYVRNL---ATGGEacppelveRWSER-G 1320
Cdd:PRK10946   252 TVVLAP------DPSATlcfpLIEKHQVNVTALVPPAVslwlqAIAEGGSRAQLASLkllQVGGA--------RLSETlA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1321 RRI---FNC-----YGPTEATVWATRSR-------MTAGKPVTigkPVDgfTVRVLDGRLHEVPQGVVGELYLSTAGLAR 1385
Cdd:PRK10946   318 RRIpaeLGCqlqqvFGMAEGLVNYTRLDdsderifTTQGRPMS---PDD--EVWVADADGNPLPQGEVGRLMTRGPYTFR 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1386 GYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV 1465
Cdd:PRK10946   393 GYYKSPQHNASAFDANGF-------YCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSM 465

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 1466 ESTRGGRKHtevVAYLVAK-PGATIDSAAVLDEaaQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK10946   466 EDELMGEKS---CAFLVVKePLKAVQLRRFLRE--QGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526

PLN02330

4-coumarate--CoA ligase-like 1

2560-3065

6.09e-13

4-coumarate--CoA ligase-like 1

Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 74.63 E-value: 6.09e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2560 PATDPVTLAELFRAAARRAPDHVAVVDGA-GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAK 2638
Cdd:PLN02330    23 PVPDKLTLPDFVLQDAELYADKVAFVEAVtGKAVTYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMA 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2639 TGGAYVPIDPDYPAERVASMIEDSGAVLGLS-VLASGDLPGQEFEWMRLDDDSVAAEI-------AAVPAGPITDAErlg 2710
Cdd:PLN02330   103 AGGVFSGANPTALESEIKKQAEAAGAKLIVTnDTNYGKVKGLGLPVIVLGEEKIEGAVnwkelleAADRAGDTSDNE--- 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2711 EVTAANLAYVIYTSGSTGRPKGVAVTHSGL-ANFArqeSDRLNAGDNPV----VLGFAsPSFDA-SVLEYLLATV-NEGT 2783
Cdd:PLN02330   180 EILQTDLCALPFSSGTTGISKGVMLTHRNLvANLC---SSLFSVGPEMIgqvvTLGLI-PFFHIyGITGICCATLrNKGK 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2784 LAyrpseAVGGEVLERF---IAEHGATHTFLTPSVLSTM---------DPTAVPSLRVIAAGGEAVPQPIV--DRWAPAT 2849
Cdd:PLN02330   256 VV-----VMSRFELRTFlnaLITQEVSFAPIVPPIILNLvknpiveefDLSKLKLQAIMTAAAPLAPELLTafEAKFPGV 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2850 ELHNLYGPTETTIgITISSamrpGDPVR---------LGGPIGGVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDR 2919
Cdd:PLN02330   331 QVQEAYGLTEHSC-ITLTH----GDPEKghgiakknsVGFILPNLEVKFIDpDTGRSLPKNTPGELCVRSQCVMQGYYNN 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2920 SGLTAERFTANPYgtagqrmYRTGDVVRWTPDTDtggltLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV 2999
Cdd:PLN02330   406 KEETDRTIDEDGW-------LHTGDIGYIDDDGD-----IFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPL 473

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 3000 GGSVATALAAYIVPVDGAVEVSE--LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALPEPVLE 3065
Cdd:PLN02330   474 PDEEAGEIPAACVVINPKAKESEedILNFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRLLKEKMLS 541

PRK07768

long-chain-fatty-acid--CoA ligase; Validated

1066-1529

7.38e-13

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 74.26 E-value: 7.38e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1066 EFETRTNAIARALLARGVSPEDVVAV--GMERSIG-SVLATWgviKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAS 1142
Cdd:PRK07768    34 EVHERARRIAGGLAAAGVGPGDAVAVlaGAPVEIApTAQGLW---MRGASLTMLHQPTPRTDLAVWAEDTLRVIGMIGAK 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1143 T----------RARLGESSCEWVDLADLEAeAESGDDITDTERNgsvrltnLAYLIYTSGSTGRPKAVGVSHTgivDFVN 1212
Cdd:PRK07768   111 AvvvgepflaaAPVLEEKGIRVLTVADLLA-ADPIDPVETGEDD-------LALMQLTSGSTGSPKAVQITHG---NLYA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1213 SLAKITTGTPEDEPDTRILHVASPSFDASMFEmAWAIP--AGHTLVIAPQADFAGDAL--ATVLERDEVTdMIITP---- 1284
Cdd:PRK07768   180 NAEAMFVAAEFDVETDVMVSWLPLFHDMGMVG-FLTVPmyFGAELVKVTPMDFLRDPLlwAELISKYRGT-MTAAPnfay 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1285 SVLA---TVDPERAQY----VRNLATGGEACPPELVERWSERGRR-------IFNCYGPTEATVWATRSRMTAG------ 1344
Cdd:PRK07768   258 ALLArrlRRQAKPGAFdlssLRFALNGAEPIDPADVEDLLDAGARfglrpeaILPAYGMAEATLAVSFSPCGAGlvvdev 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 ---------------KP-----VTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGYLgrpgqTAVSFVA--DP 1402
Cdd:PRK07768   338 dadllaalrravpatKGntrrlATLGPPLPGLEVRVVDEDGQVLPPRGVGVIELRGESVTPGYL-----TMDGFIPaqDA 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1403 FGepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVAylv 1482
Cdd:PRK07768   413 DG-----WLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIERAAARVEGVRPGNAVAVRLDAGHSREGFAVA--- 484

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1483 akpgatIDSAAVLDEAA----QHLAAHMV-------PSQAIVID--EIPLTPAGKLDRAA 1529
Cdd:PRK07768   485 ------VESNAFEDPAEvrriRHQVAHEVvaevgvrPRNVVVLGpgSIPKTPSGKLRRAN 538

Cyc_NRPS

cd19535

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

2146-2430

9.13e-13

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the Condensation-domain family; Cyc (heterocyclization) domains catalyze two separate reactions in the creation of heterocyclized peptide products in nonribosomal peptide synthesis: amide bond formation followed by intramolecular cyclodehydration between a Cys, Ser, or Thr side chain and a carbonyl carbon on the peptide backbone to form a thiazoline, oxazoline, or methyloxazoline ring. Cyc-domains are homologous to standard NRPS Condensation (C) domains. C-domains typically have a conserved HHxxxD motif at the active site; Cyc-domains have an alternative, conserved DxxxxD active site motif, mutation of the aspartate residues in this motif can abolish or diminish condensation activity. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and Cyc-domains. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 73.29 E-value: 9.13e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2146 DVDPGRLRSALSELLARQRVLRSGFvrLPSGaaVTVVPAEVTVP-WSVIDLRAEDAASLDSRVEEV---LATERtnpFDM 2221
Cdd:cd19535     36 DLDPDRLERAWNKLIARHPMLRAVF--LDDG--TQQILPEVPWYgITVHDLRGLSEEEAEAALEELrerLSHRV---LDV 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2222 AKPPLIRVVLVEHGDGAELVVTNHHLLI-DGWSSPLVLADLLSLYATGQTftgSLPgTSGRDFAD---HARAVATADVEA 2297
Cdd:cd19535    109 ERGPLFDIRLSLLPEGRTRLHLSIDLLVaDALSLQILLRELAALYEDPGE---PLP-PLELSFRDyllAEQALRETAYER 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2298 GIAAWREVLapvtePTLvapghePSADAPP--------RDHQFS-----IDVKVTERLEALARNNSTTMATVVQFAWAMF 2364
Cdd:cd19535    185 ARAYWQERL-----PTL------PPAPQLPlakdpeeiKEPRFTrrehrLSAEQWQRLKERARQHGVTPSMVLLTAYAEV 253

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2365 LSRLTGTRTVTFAETVSGRSPDIEGMESMVGMFINTIPAVVDVNPDATVVDVLTAVQNDKVKVLDH 2430
Cdd:cd19535    254 LARWSGQPRFLLNLTLFNRLPLHPDVNDVVGDFTSLLLLEVDGSEGQSFLERARRLQQQLWEDLDH 319

MACS_like_1

cd05974

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

118-418

9.14e-13

Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 73.37 E-value: 9.14e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  118 TRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFL-YKAPITFDVSVREIFLPIAIGATLVIAEPG 196
Cdd:cd05974     82 THADDPMLLYFTSGTTSKPKLVEHTHRSYPVGHLSTMYWIGLKPGDVHWnISSPGWAKHAWSCFFAPWNAGATVFLFNYA 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  197 RHgDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGelTSLRLIQTGGEALTPPVArDLMVRLPGTRLQNQYGPAEA 276
Cdd:cd05974    162 RF-DAKRVLAALVRYGVTTLCAPPTVWRMLIQQDLASFD--VKLREVVGAGEPLNPEVI-EQVRRAWGLTIRDGYGQTET 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  277 SIVVTiHRVTQDDRVIPIGTPTRRVSARVLDAALREVPigvPGELYLG-----GVQLARGYAGRPDLTAERFvadpfgep 351
Cdd:cd05974    238 TALVG-NSPGQPVKAGSMGRPLPGYRVALLDPDGAPAT---EGEVALDlgdtrPVGLMKGYAGDPDKTAHAM-------- 305

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616  352 GARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPGGQQL 418
Cdd:cd05974    306 RGGYYRTGDIAMRDEDGYLTYVGRADDVFKSSDYRISPFELESVLIEHPAV--AEAAVVPSPDPVRL 370

A_NRPS_MycA_like

cd05908

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...

124-375

9.86e-13

Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 73.68 E-value: 9.86e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  124 AFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVreiflpIAIGATLVIAepGRHGDPVH 203
Cdd:cd05908    109 AFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKDRILSWMPLTHDMGL------IAFHLAPLIA--GMNQYLMP 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  204 LADLIRR----------HGVTVI---HFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQ-- 268
Cdd:cd05908    181 TRLFIRRpilwlkkaseHKATIVsspNFGYKYFLKTLKPEKANDWDLSSIRMILNGAEPIDYELCHEFLDHMSKYGLKrn 260

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  269 ---NQYGPAEASI------------VVTIHR-----------VTQDD----RVIPIGTPTRRVSARVLDAALREVPIGVP 318
Cdd:cd05908    261 ailPVYGLAEASVgaslpkaqspfkTITLGRrhvthgepepeVDKKDseclTFVEVGKPIDETDIRICDEDNKILPDGYI 340

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616  319 GELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRArWNRDGEIEYLGR 375
Cdd:cd05908    341 GHIQIRGKNVTPGYYNNPEATAKVFTDDGW-------LKTGDLG-FIRNGRLVITGR 389

PP-binding

pfam00550

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...

487-545

1.81e-12

Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 64.51 E-value: 1.81e-12

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616  487 ETVAGLFAELLGV--ERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVR 545
Cdd:pfam00550    1 ERLRELLAEVLGVpaEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61

PRK09274

peptide synthase; Provisional

117-440

1.95e-12

peptide synthase; Provisional

Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 73.01 E-value: 1.95e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  117 PTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYkapiTFDVSVreiFLPIAIGATLVIAE-- 194
Cdd:PRK09274   170 DLAPDDMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYGIEPGEIDLP----TFPLFA---LFGPALGMTSVIPDmd 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  195 PGRHG--DPVHLADLIRRHGVTVIHFVPAMLaafNEVLGAGVGE---LTSLRLIQTGGealtPPVARDLMVRL-----PG 264
Cdd:PRK09274   243 PTRPAtvDPAKLFAAIERYGVTNLFGSPALL---ERLGRYGEANgikLPSLRRVISAG----APVPIAVIERFramlpPD 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  265 TRLQNQYGPAEASIVVTI---------HRVTQDDRVIPIGTPTRRVSARVL---DAAL------REVPIGVPGELYLGGV 326
Cdd:PRK09274   316 AEILTPYGATEALPISSIesreilfatRAATDNGAGICVGRPVDGVEVRIIaisDAPIpewddaLRLATGEIGEIVVAGP 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  327 QLARGYAGRPDLTAERFVADPfgEPGARlYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAA 406
Cdd:PRK09274   396 MVTRSYYNRPEATRLAKIPDG--QGDVW-HRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSA 472

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1827387616  407 AAVVDGPGGQQLVGYLAPADVDVDTVAATTAELL 440
Cdd:PRK09274   473 LVGVGVPGAQRPVLCVELEPGVACSKSALYQELR 506

AcpP

COG0236

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...

3071-3144

2.06e-12

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis

Pssm-ID: 440006 [Multi-domain] Cd Length: 80 Bit Score: 64.87 E-value: 2.06e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 3071 APATGTERTIADVAAGVLNIDAGLVSATSSFF-ELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAETV 3144
Cdd:COG0236      1 MPREELEERLAEIIAEVLGVDPEEITPDDSFFeDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYL 75

PRK08180

feruloyl-CoA synthase; Reviewed

2564-2948

2.68e-12

feruloyl-CoA synthase; Reviewed

Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 72.60 E-value: 2.68e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAVV----DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRS---AQL-LTAIWA 2635
Cdd:PRK08180    38 PRRLTDRLVHWAQEAPDRVFLAergaDGGWRRLTYAEALERVRAIAQALLDRGLSAERPLMILSGNSiehALLaLAAMYA 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2636 vaktGGAYVPIDPDYPA-----ERVASMIEdsgaVL--GLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPIT---- 2704
Cdd:PRK08180   118 ----GVPYAPVSPAYSLvsqdfGKLRHVLE----LLtpGLVFADDGAAFARALAAVVPADVEVVAVRGAVPGRAATpfaa 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2705 --DAERLGEVTAAN-------LAYVIYTSGSTGRPKGVAVTHSGL-ANFA--RQESDRLnAGDNPVVLGFA--SPSFDAS 2770
Cdd:PRK08180   190 llATPPTAAVDAAHaavgpdtIAKFLFTSGSTGLPKAVINTHRMLcANQQmlAQTFPFL-AEEPPVLVDWLpwNHTFGGN 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2771 -VLEYLLAtvNEGTLaY----RPSEAVGGEVLERfiaehgathtfltpsvLSTMDPTA---VPS---------------- 2826
Cdd:PRK08180   269 hNLGIVLY--NGGTL-YiddgKPTPGGFDETLRN----------------LREISPTVyfnVPKgwemlvpalerdaalr 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2827 ------LRVIAAGGEAVPQPIVDRWAPATELH--------NLYGPTETTIGITISS--AMRPGDpvrLGGPIGGVDlmvl 2890
Cdd:PRK08180   330 rrffsrLKLLFYAGAALSQDVWDRLDRVAEATcgerirmmTGLGMTETAPSATFTTgpLSRAGN---IGLPAPGCE---- 402

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 2891 derLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRW 2948
Cdd:PRK08180   403 ---VKLVPVGGKLEVRVKGPNVTPGYWRAPELTAEAFDEEGY-------YRSGDAVRF 450

AMP-binding_C

pfam13193

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...

2980-3053

3.13e-12

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.

Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 64.10 E-value: 3.13e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2980 EIEAVLAEHDAVESAVVLGVGGSV-ATALAAYIVPVDGAVEVS-ELKAFAGGRLPAYMVPSSFTVIDELPLTPVGK 3053
Cdd:pfam13193    1 EVESALVSHPAVAEAAVVGVPDELkGEAPVAFVVLKPGVELLEeELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76

PLN02246

4-coumarate--CoA ligase

1050-1530

3.89e-12

4-coumarate--CoA ligase

Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 71.94 E-value: 3.89e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALI--CDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAY 1127
Cdd:PLN02246    37 SDRPCLIdgATGRVYTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTANPFYTPAEIAK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1128 MLEDSGATVGITDAStrarlgessceWVD-LADLEAEaesgDDIT----DTERNGSVRLTNL------------------ 1184
Cdd:PLN02246   117 QAKASGAKLIITQSC-----------YVDkLKGLAED----DGVTvvtiDDPPEGCLHFSELtqadenelpeveispddv 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1185 AYLIYTSGSTGRPKAVGVSHTGIvdfVNSLAKITTG-------TPEDepdtRILHVaspsfdASMFE-------MAWAIP 1250
Cdd:PLN02246   182 VALPYSSGTTGLPKGVMLTHKGL---VTSVAQQVDGenpnlyfHSDD----VILCV------LPMFHiyslnsvLLCGLR 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1251 AGHTLVIAPQADFAgdALATVLERDEVT-DMIITPSVLATV-DPERAQY----VRNLATGGEACPPELVERWSER--GRR 1322
Cdd:PLN02246   249 VGAAILIMPKFEIG--ALLELIQRHKVTiAPFVPPIVLAIAkSPVVEKYdlssIRMVLSGAAPLGKELEDAFRAKlpNAV 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1323 IFNCYGPTEATVWATRSRMTAGKPVTI-----GKPVDGFTVRVLDGRLHE-VPQGVVGELYLSTAGLARGYLGRPGQTAV 1396
Cdd:PLN02246   327 LGQGYGMTEAGPVLAMCLAFAKEPFPVksgscGTVVRNAELKIVDPETGAsLPRNQPGEICIRGPQIMKGYLNDPEATAN 406

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1397 SFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhtE 1476
Cdd:PLN02246   407 TIDKDGW-------LHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVVPMKDEVAG----E 475

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1477 V-VAYLVAKPGATIDSaavlDEAAQHLAAHMVPSQAI----VIDEIPLTPAGKLDRAAL 1530
Cdd:PLN02246   476 VpVAFVVRSNGSEITE----DEIKQFVAKQVVFYKRIhkvfFVDSIPKAPSGKILRKDL 530

LC_FACL_like

cd05914

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...

2-429

4.67e-12

Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 71.32 E-value: 4.67e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTsd 81
Cdd:cd05914      9 TYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAIFVS-- 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   82 geaearsrfddivdvhvldisspgdadlDEEEFAgptrpanaaFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYDLTA 161
Cdd:cd05914     87 ----------------------------DEDDVA---------LINYTSGTTGNSKGVMLTYRNIVSNVDGVKEVVLLGK 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  162 RDVFL------YKAPITFDvsvreIFLPIAIGATLVIAEPgrhgDPVHLADLIRRHGVTVIHFVPAML------------ 223
Cdd:cd05914    130 GDKILsilplhHIYPLTFT-----LLLPLLNGAHVVFLDK----IPSAKIIALAFAQVTPTLGVPVPLviekifkmdiip 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  224 ----------------------AAFNEVLGAGVGeltSLRLIQTGGEALTPPVARDLmvRLPGTRLQNQYGPAEASIVVT 281
Cdd:cd05914    201 kltlkkfkfklakkinnrkirkLAFKKVHEAFGG---NIKEFVIGGAKINPDVEEFL--RTIGFPYTIGYGMTETAPIIS 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  282 IHRvTQDDRVIPIGTPTRRVSARVLDaalrEVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDR 361
Cdd:cd05914    276 YSP-PNRIRLGSAGKVIDGVEVRIDS----PDPATGEGEIIVRGPNVMKGYYKNPEATAEAFDKDGW-------FHTGDL 343

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  362 ARWNRDGEIEYLGRT-DFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGgqQLVGYLAPADVDV 429
Cdd:cd05914    344 GKIDAEGYLYIRGRKkEMIVLSSGKNIYPEEIEAKINNMPFVLESLVVVQEKKL--VALAYIDPDFLDV 410

PRK06814

acyl-[ACP]--phospholipid O-acyltransferase;

2562-3073

6.06e-12

acyl-[ACP]--phospholipid O-acyltransferase;

Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 71.92 E-value: 6.06e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2562 TDPVTLAELFRAAARRAPDHVAVVDGAGARLTYRELDEASDRLARwLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGg 2641
Cdd:PRK06814   629 YDRTLFEALIEAAKIHGFKKLAVEDPVNGPLTYRKLLTGAFVLGR-KLKKNTPPGENVGVMLPNANGAAVTFFALQSAG- 706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2642 ayvpidpdypaeRVASMIE-DSGAVlglSVLASGDLPG-------QEF-EWMRLDDdsVAAEIAA---------VPAGpI 2703
Cdd:PRK06814   707 ------------RVPAMINfSAGIA---NILSACKAAQvktvltsRAFiEKARLGP--LIEALEFgiriiyledVRAQ-I 768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2704 TDAERLGEVTAANL-------------AYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLG----FASPS 2766
Cdd:PRK06814   769 GLADKIKGLLAGRFplvyfcnrdpddpAVILFTSGSEGTPKGVVLSHRNLLANRAQVAARIDFSPEDKVFNalpvFHSFG 848

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2767 FDASVLEYLLATVN----EGTLAYRpseavggeVLERFIAEHGATHTFLTPSVLSTMDPTAVP----SLRVIAAGGEAVP 2838
Cdd:PRK06814   849 LTGGLVLPLLSGVKvflyPSPLHYR--------IIPELIYDTNATILFGTDTFLNGYARYAHPydfrSLRYVFAGAEKVK 920

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2839 QPIVDRWAPATELHNL--YGPTETTIGITISSAM--RPGDPVRLggpiggvdLMVLDERLRPVP-VGMPGELYVAGGALS 2913
Cdd:PRK06814   921 EETRQTWMEKFGIRILegYGVTETAPVIALNTPMhnKAGTVGRL--------LPGIEYRLEPVPgIDEGGRLFVRGPNVM 992

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2914 RGYLDrsgltaerfTANP--YGTAGQRMYRTGDVVrwTPDTDtGGLTLEytGRSDDQVKLRGLRIELGEIEAVLAE--HD 2989
Cdd:PRK06814   993 LGYLR---------AENPgvLEPPADGWYDTGDIV--TIDEE-GFITIK--GRAKRFAKIAGEMISLAAVEELAAElwPD 1058

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2990 AVESAV-----------VLGVGGSVATAlaayivpvdgavevSELKAFAGGR-LPAYMVPSSFTVIDELPLTPVGKLDKR 3057
Cdd:PRK06814  1059 ALHAAVsipdarkgeriILLTTASDATR--------------AAFLAHAKAAgASELMVPAEIITIDEIPLLGTGKIDYV 1124

                          570
                   ....*....|....*.
gi 1827387616 3058 ALPEPVLEAGEYVAPA 3073
Cdd:PRK06814  1125 AVTKLAEEAAAKPEAA 1140

LC_FACS_bac1

cd17641

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...

4-414

7.77e-12

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 70.91 E-value: 7.77e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVtSDGE 83
Cdd:cd17641     15 ADYADRVRAFALGLLALGVGRGDVVAILGDNRPEWVWAELAAQAIGALSLGIYQDSMAEEVAYLLNYTGARVVIA-EDEE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 --------------------AEAR--SRFDDIVDVHVLDISSPGDA------DLDEEEFAGpTRPANAAFTLFTSGSTGR 135
Cdd:cd17641     94 qvdklleiadripsvryviyCDPRgmRKYDDPRLISFEDVVALGRAldrrdpGLYEREVAA-GKGEDVAVLCTTSGTTGK 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  136 PKAVVITHRGI----ANRLAAD------------------------------------IEQYDLTARDV------FLYKA 169
Cdd:cd17641    173 PKLAMLSHGNFlghcAAYLAADplgpgdeyvsvlplpwigeqmysvgqalvcgfivnfPEEPETMMEDLreigptFVLLP 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  170 PITF-----DVSVR--------EIFLPIAIGATLVIAEPGRHGDPVHLADLIRRHgvtviHFVPAMLAAFNEVLGagvge 236
Cdd:cd17641    253 PRVWegiaaDVRARmmdatpfkRFMFELGMKLGLRALDRGKRGRPVSLWLRLASW-----LADALLFRPLRDRLG----- 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 LTSLRLIQTGGEALTPPVARdlMVRLPGTRLQNQYGPAEASIVVTIHRvtqDDRVIP--IGTPTRRVSARVLDAalrevp 314
Cdd:cd17641    323 FSRLRSAATGGAALGPDTFR--FFHAIGVPLKQLYGQTELAGAYTVHR---DGDVDPdtVGVPFPGTEVRIDEV------ 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  315 igvpGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGR-TDFQVKLRGQRLELGEVE 393
Cdd:cd17641    392 ----GEILVRSPGVFVGYYKNPEATAEDFDEDGW-------LHTGDAGYFKENGHLVVIDRaKDVGTTSDGTRFSPQFIE 460

                          490       500
                   ....*....|....*....|.
gi 1827387616  394 AALAAAPGVlhaAAAVVDGPG 414
Cdd:cd17641    461 NKLKFSPYI---AEAVVLGAG 478

LC_FACS_euk1

cd17639

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...

1062-1527

1.05e-11

Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 70.32 E-value: 1.05e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1062 MDYDEFETRTNAIARALLARGVSPEDVVAVGMERSigsvlATWGVIKSGAAyvpvdpaypadriaymledsgaTVGITDA 1141
Cdd:cd17639      6 MSYAEVWERVLNFGRGLVELGLKPGDKVAIFAETR-----AEWLITALGCW----------------------SQNIPIV 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1142 STRARLGESscewvDLADLEAEAESGDDITDTERNGsvrltnLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGT 1221
Cdd:cd17639     59 TVYATLGED-----ALIHSLNETECSAIFTDGKPDD------LACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPEL 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1222 PEdePDTRIL------HVASpsFDASMFEMAWAIPAGH----TLVIAPQADFAGD----------ALATVLERdevtdmi 1281
Cdd:cd17639    128 LG--PDDRYLaylplaHIFE--LAAENVCLYRGGTIGYgsprTLTDKSKRGCKGDltefkptlmvGVPAIWDT------- 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1282 ITPSVLATVDP---------------ERAQY------------------------VRNLATGGEACPPELVERWSERGRR 1322
Cdd:cd17639    197 IRKGVLAKLNPmgglkrtlfwtayqsKLKALkegpgtplldelvfkkvraalggrLRYMLSGGAPLSADTQEFLNIVLCP 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1323 IFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDgrlheVPQGVV--------GELYLSTAGLARGYLGRPGQT 1394
Cdd:cd17639    277 VIQGYGLTETCAGGTVQDPGDLETGRVGPPLPCCEIKLVD-----WEEGGYstdkppprGEILIRGPNVFKGYYKNPEKT 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1395 AVSFVADpfgepgaRMYATGDLVRVAKGGNLEFAGRADHQVKI-NGQRVELGEIEAVLDAQPGVAQSVVVGVEStrggrk 1473
Cdd:cd17639    352 KEAFDGD-------GWFHTGDIGEFHPDGTLKIIDRKKDLVKLqNGEYIALEKLESIYRSNPLVNNICVYADPD------ 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1474 HTEVVAYLV-------------AKPGATIDS--------AAVLDE-----AAQHLAAHMVPsQAIVIDEIP-------LT 1520
Cdd:cd17639    419 KSYPVAIVVpnekhltklaekhGVINSEWEElcedkklqKAVLKSlaetaRAAGLEKFEIP-QGVVLLDEEwtpenglVT 497


                   ....*..
gi 1827387616 1521 PAGKLDR 1527
Cdd:cd17639    498 AAQKLKR 504

AFD_CAR-like

cd17632

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ...

2559-3025

1.14e-11

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.

Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 70.56 E-value: 1.14e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2559 GPATDPVTLAELFRAAARRAPdhvavvdgagarLTYREL-DEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVA 2637
Cdd:cd17632     47 ELVTDPATGRTTLRLLPRFET------------ITYAELwERVGAVAAAHDPEQPVRPGDFVAVLGFTSPDYATVDLALT 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2638 KTGGAYVPIDPDYPAERVASMIEDSG----AV------LGLSVLASGDLPGQ--------EFEWMRLDDDSVAAEIAAVP 2699
Cdd:cd17632    115 RLGAVSVPLQAGASAAQLAPILAETEprllAVsaehldLAVEAVLEGGTPPRlvvfdhrpEVDAHRAALESARERLAAVG 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2700 AGPITDAERLGEVTAAN-------------LAYVIYTSGSTGRPKGVAVTHSGLANFARQeSDRLNAGDNP--VVLGFAS 2764
Cdd:cd17632    195 IPVTTLTLIAVRGRDLPpaplfrpepdddpLALLIYTSGSTGTPKGAMYTERLVATFWLK-VSSIQDIRPPasITLNFMP 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2765 PSFDASVLeYLLATVNEGTLAY-----------------RPSEA-----VGGEVLERFIAEHGATHTflTPSVLSTMDPT 2822
Cdd:cd17632    274 MSHIAGRI-SLYGTLARGGTAYfaaasdmstlfddlalvRPTELflvprVCDMLFQRYQAELDRRSV--AGADAETLAER 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2823 AVPSLRVIAAGGE---AV--PQPIVDR------WAPATELHNLYGPTETTIGITISSAMRPGdpvrlggpiggvdlmVLD 2891
Cdd:cd17632    351 VKAELRERVLGGRllaAVcgSAPLSAEmkafmeSLLDLDLHDGYGSTEAGAVILDGVIVRPP---------------VLD 415

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2892 ERLRPVP------VGMP---GELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVrwtpdTDTGGLTLEYT 2962
Cdd:cd17632    416 YKLVDVPelgyfrTDRPhprGELLVKTDTLFPGYYKRPEVTAEVFDEDGF-------YRTGDVM-----AELGPDRLVYV 483

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 2963 GRSDDQVKL-RGLRIELGEIEAVLAEHDAVESAVVLgvGGSVATALAAYIVPVDGAVE---VSELKA 3025
Cdd:cd17632    484 DRRNNVLKLsQGEFVTVARLEAVFAASPLVRQIFVY--GNSERAYLLAVVVPTQDALAgedTARLRA 548

MACS_euk

cd05928

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...

2713-3059

1.28e-11

Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 70.19 E-value: 1.28e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2713 TAANLAYVIY-TSGSTGRPKGVAVTHS----GLANFAR-----QESDRL-NAGDNPVVLGFASPSFD-----ASVLEYLL 2776
Cdd:cd05928    171 TGSQEPMAIYfTSGTTGSPKMAEHSHSslglGLKVNGRywldlTASDIMwNTSDTGWIKSAWSSLFEpwiqgACVFVHHL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2777 ATVNEGTLAyrpseavggEVLERFiaehgATHTFLTPSVLSTM----DPTAV--PSLRVIAAGGEAVPQPIVDRWAPAT- 2849
Cdd:cd05928    251 PRFDPLVIL---------KTLSSY-----PITTFCGAPTVYRMlvqqDLSSYkfPSLQHCVTGGEPLNPEVLEKWKAQTg 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2850 -ELHNLYGPTETTIGITISSAM--RPGDpvrLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGG-----ALSRGYLDRSG 2921
Cdd:cd05928    317 lDIYEGYGQTETGLICANFKGMkiKPGS---MGKASPPYDVQIIDDNGNVLPPGTEGDIGIRVKpirpfGLFSGYVDNPE 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2922 LTAERFTANPYGTaGQRMYRTGDVVRWtpdtdtggltleYTGRSDDQVKLRGLRIELGEIEAVLAEHDAV-ESAVVLG-- 2998
Cdd:cd05928    394 KTAATIRGDFYLT-GDRGIMDEDGYFW------------FMGRADDVINSSGYRIGPFEVESALIEHPAVvESAVVSSpd 460

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 2999 -VGGSVATA---LAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05928    461 pIRGEVVKAfvvLAPQFLSHDPEQLTKELQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNEL 525

LC_FACS_euk1

cd17639

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...

1-402

1.37e-11

Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 69.94 E-value: 1.37e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGghfvpldeqlpvdrarymvrtagvrLVVVT- 79
Cdd:cd17639      6 MSYAEVWERVLNFGRGLVELGLKPGDKVAIFAETRAEWLITALGCWSQN-------------------------IPIVTv 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   80 --SDGEaearsrfDDIVdvHVLD-------ISSPGDADLdeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRL 150
Cdd:cd17639     61 yaTLGE-------DALI--HSLNetecsaiFTDGKPDDL--------------ACIMYTSGSTGNPKGVMLTHGNLVAGI 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  151 AA--DIEQYDLTARDVFLYKAPIT--FDVSVREIFLpiAIGATLVIAEP---------GRHGD-----PVHLA------D 206
Cdd:cd17639    118 AGlgDRVPELLGPDDRYLAYLPLAhiFELAAENVCL--YRGGTIGYGSPrtltdkskrGCKGDltefkPTLMVgvpaiwD 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  207 LIRRhgvTVIHFVPAM---------------LAA---------FNEVLGAGVGELTS--LRLIQTGGEALTPPVARDLMV 260
Cdd:cd17639    196 TIRK---GVLAKLNPMgglkrtlfwtayqskLKAlkegpgtplLDELVFKKVRAALGgrLRYMLSGGAPLSADTQEFLNI 272

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  261 RLpGTRLQNqYGPAEASIVVTIHRVTQ--DDRVipiGTPTRRVSARVLDAA-LREVPIGVP--GELYLGGVQLARGYAGR 335
Cdd:cd17639    273 VL-CPVIQG-YGLTETCAGGTVQDPGDleTGRV---GPPLPCCEIKLVDWEeGGYSTDKPPprGEILIRGPNVFKGYYKN 347

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616  336 PDLTAERFVADpfgepgaRLYRTGDRARWNRDGEIEYLGRTDFQVKLR-GQRLELGEVEAALAAAPGV 402
Cdd:cd17639    348 PEKTKEAFDGD-------GWFHTGDIGEFHPDGTLKIIDRKKDLVKLQnGEYIALEKLESIYRSNPLV 408

AcpP

COG0236

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...

486-554

1.75e-11

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis

Pssm-ID: 440006 [Multi-domain] Cd Length: 80 Bit Score: 62.18 E-value: 1.75e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  486 EETVAGLFAELLGV--ERVGVTDSFF-DIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVRGLVHAVSGR 554
Cdd:COG0236      7 EERLAEIIAEVLGVdpEEITPDDSFFeDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78

PRK05620

long-chain fatty-acid--CoA ligase;

4-468

2.94e-11

long-chain fatty-acid--CoA ligase;

Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 69.04 E-value: 2.94e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLAREL-TALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTA----------- 71
Cdd:PRK05620    42 AAIGARAAALAHALhDELGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAedevivadprl 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   72 ------------GVRLVVVTSDGEAeARSRFDDIVDVHVLDIsspgDADLDEE--EFAGPTRPANAAFTL-FTSGSTGRP 136
Cdd:PRK05620   122 aeqlgeilkecpCVRAVVFIGPSDA-DSAAAHMPEGIKVYSY----EALLDGRstVYDWPELDETTAAAIcYSTGTTGAP 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  137 KAVVITHRGI----ANRLAADieQYDLTARDVFLYKAPItfdVSVREIFLPIAI---GATLVIaePGRHGDPVHLADLIR 209
Cdd:PRK05620   197 KGVVYSHRSLylqsLSLRTTD--SLAVTHGESFLCCVPI---YHVLSWGVPLAAfmsGTPLVF--PGPDLSAPTLAKIIA 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  210 RHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALtPPVARDLMVRLPGTRLQNQYGPAEASIVVTI------- 282
Cdd:PRK05620   270 TAMPRVAHGVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAV-PPILIKAWEERYGVDVVHVWGMTETSPVGTVarppsgv 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  283 -------HRVTQDDrvIPIGTPTRRVS-ARVLDAALREvpigvPGELYLGGVQLARGY----AGRPDLTAERFVADPFGE 350
Cdd:PRK05620   349 sgearwaYRVSQGR--FPASLEYRIVNdGQVMESTDRN-----EGEIQVRGNWVTASYyhspTEEGGGAASTFRGEDVED 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  351 PGARL-----YRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-AVVDGPGGQQ--LVGYL 422
Cdd:PRK05620   422 ANDRFtadgwLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAViGYPDDKWGERplAVTVL 501

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  423 APadvDVDTVAATTAEL-------LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK05620   502 AP---GIEPTRETAERLrdqlrdrLPNWMLPEYWTFVDEIDKTSVGKFDKKDL 551

PRK12476

putative fatty-acid--CoA ligase; Provisional

1041-1529

3.22e-11

putative fatty-acid--CoA ligase; Provisional

Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 69.00 E-value: 3.22e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1041 DVLAQRDLDPDHPALICdGTEMDYDEFETRTNAIArALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPV-DPA 1119
Cdd:PRK12476    49 DTVAYRYLDHSHSAAGC-AVELTWTQLGVRLRAVG-ARLQQVAGPGDRVAILAPQGIDYVAGFFAAIKAGTIAVPLfAPE 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1120 YP--ADRIAYMLEDSGATVGITDASTRARLGESscewvdLADLEAEAESG----DDITDTERNGSVRLT----NLAYLIY 1189
Cdd:PRK12476   127 LPghAERLDTALRDAEPTVVLTTTAAAEAVEGF------LRNLPRLRRPRviaiDAIPDSAGESFVPVEldtdDVSHLQY 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1190 TSGSTGRPKAVGVSHTGIVdfVNSLAKITTGTPEDePDTR------------ILHVASPS--------FDASMF------ 1243
Cdd:PRK12476   201 TSGSTRPPVGVEITHRAVG--TNLVQMILSIDLLD-RNTHgvswlplyhdmgLSMIGFPAvygghstlMSPTAFvrrpqr 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1244 ---EMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTD-----MII--TPSVLATVDperaqyVRNLATGGEACPPELV 1313
Cdd:PRK12476   278 wikALSEGSRTGRVVTAAPNFAYEWAAQRGLPAEGDDIDlsnvvLIIgsEPVSIDAVT------TFNKAFAPYGLPRTAF 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1314 ErwsergrrifNCYGPTEAT--------------VWATRSRMTAGKPVTIGKPVDGFTVRVLDGRL-------------- 1365
Cdd:PRK12476   352 K----------PSYGIAEATlfvatiapdaepsvVYLDREQLGAGRAVRVAADAPNAVAHVSCGQVarsqwavivdpdtg 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1366 HEVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVAD-----PFG------EPGARMYATGDLvRVAKGGNLEFAGRADHQ 1434
Cdd:PRK12476   422 AELPDGEVGEIWLHGDNIGRGYWGRPEETERTFGAKlqsrlAEGshadgaADDGTWLRTGDL-GVYLDGELYITGRIADL 500

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1435 VKINGQRVELGEIEA-VLDAQPGVAQSVVVGVESTRGGRKHTEVVAYLV-----AKPGATIDS--AAVLDEAAQHLA-AH 1505
Cdd:PRK12476   501 IVIDGRNHYPQDIEAtVAEASPMVRRGYVTAFTVPAEDNERLVIVAERAagtsrADPAPAIDAirAAVSRRHGLAVAdVR 580

                          570       580
                   ....*....|....*....|....
gi 1827387616 1506 MVPSQAivideIPLTPAGKLDRAA 1529
Cdd:PRK12476   581 LVPAGA-----IPRTTSGKLARRA 599

PLN02479

acetate-CoA ligase

2722-3067

4.45e-11

acetate-CoA ligase

Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 68.72 E-value: 4.45e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2722 YTSGSTGRPKGVAVTHSGLanfarqesdRLNAGDNPVVLG--------FASPSFDAS--VLEYLLATVNEGTLAYRPSEA 2791
Cdd:PLN02479   202 YTSGTTASPKGVVLHHRGA---------YLMALSNALIWGmnegavylWTLPMFHCNgwCFTWTLAALCGTNICLRQVTA 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 VGgevLERFIAEHGATHTFLTPSVLSTM-----DPTAVPSLRVI---AAGgeAVPQPIV--------DRWAPATELHNLY 2855
Cdd:PLN02479   273 KA---IYSAIANYGVTHFCAAPVVLNTIvnapkSETILPLPRVVhvmTAG--AAPPPSVlfamsekgFRVTHTYGLSETY 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2856 GPTETTIGITISSAMRPGDPVRLGGP-----IGGVDLMVLDER-LRPVPV--GMPGELYVAGGALSRGYLDRSGLTAERF 2927
Cdd:PLN02479   348 GPSTVCAWKPEWDSLPPEEQARLNARqgvryIGLEGLDVVDTKtMKPVPAdgKTMGEIVMRGNMVMKGYLKNPKANEEAF 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2928 tANPYgtagqrmYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAV-ESAVVLGVGGSVATA 3006
Cdd:PLN02479   428 -ANGW-------FHSGDLGVKHPDG-----YIEIKDRSKDIIISGGENISSLEVENVVYTHPAVlEASVVARPDERWGES 494

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616 3007 LAAYIVPVDGAVEVSE------LKAFAGGRLPAYMVPSSfTVIDELPLTPVGKLDKRALPEPVLEAG 3067
Cdd:PLN02479   495 PCAFVTLKPGVDKSDEaalaedIMKFCRERLPAYWVPKS-VVFGPLPKTATGKIQKHVLRAKAKEMG 560

PRK06814

acyl-[ACP]--phospholipid O-acyltransferase;

1185-1530

4.48e-11

acyl-[ACP]--phospholipid O-acyltransferase;

Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 69.22 E-value: 4.48e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1185 AYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtrILHVASPSFDASMFEMAWAIP--AGHTLV------ 1256
Cdd:PRK06814   796 AVILFTSGSEGTPKGVVLSHRNLLANRAQVAARIDFSPED-----KVFNALPVFHSFGLTGGLVLPllSGVKVFlypspl 870

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1257 ---IAPQADFAGDAlatvlerdevTDMIITPSVLA----TVDPERAQYVRNLATGGEACPPELVERWSER-GRRIFNCYG 1328
Cdd:PRK06814   871 hyrIIPELIYDTNA----------TILFGTDTFLNgyarYAHPYDFRSLRYVFAGAEKVKEETRQTWMEKfGIRILEGYG 940

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1329 PTE-ATVWATRSRMtAGKPVTIGKPVDGftvrvLDGRLHEVP---QGvvGELYLSTAGLARGYL--GRPGqtavsfVADP 1402
Cdd:PRK06814   941 VTEtAPVIALNTPM-HNKAGTVGRLLPG-----IEYRLEPVPgidEG--GRLFVRGPNVMLGYLraENPG------VLEP 1006

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1403 fgePGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEA-VLDAQPGvAQSVVVGVESTRGGrkhtEVVAYL 1481
Cdd:PRK06814  1007 ---PADGWYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEElAAELWPD-ALHAAVSIPDARKG----ERIILL 1078

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1482 VAKPGATidSAAVLDEAAQHLAAH-MVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK06814  1079 TTASDAT--RAAFLAHAKAAGASElMVPAEIITIDEIPLLGTGKIDYVAV 1126

MACS_euk

cd05928

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...

128-413

7.52e-11

Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 67.88 E-value: 7.52e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRGIANRLAADIEQY-DLTARDVFLYKAPITFDVS-VREIFLPIAIGATLVIAEPGRHgDPVHLA 205
Cdd:cd05928    181 FTSGTTGSPKMAEHSHSSLGLGLKVNGRYWlDLTASDIMWNTSDTGWIKSaWSSLFEPWIQGACVFVHHLPRF-DPLVIL 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 DLIRRHGVTVIHFVPAmlaAFNEVLGAGVG--ELTSLRLIQTGGEALTPPVaRDLMVRLPGTRLQNQYGPAEasiVVTIH 283
Cdd:cd05928    260 KTLSSYPITTFCGAPT---VYRMLVQQDLSsyKFPSLQHCVTGGEPLNPEV-LEKWKAQTGLDIYEGYGQTE---TGLIC 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIP--IGTPTRRVSARVLDAALREVPIGVPGELylgGVQLA--------RGYAGRPDLTAERFVADpfgepga 353
Cdd:cd05928    333 ANFKGMKIKPgsMGKASPPYDVQIIDDNGNVLPPGTEGDI---GIRVKpirpfglfSGYVDNPEKTAATIRGD------- 402

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  354 rLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGP 413
Cdd:cd05928    403 -FYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAV--VESAVVSSP 459

Cyc_NRPS

cd19535

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

604-917

9.49e-11

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 67.13 E-value: 9.49e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  604 DVDETLLFDSLCDVVERHEVLRTVY-----------PSVGAAPVQD---VLPVAVAREQLDWREADSVESLVRSTTEGFD 669
Cdd:cd19535     36 DLDPDRLERAWNKLIARHPMLRAVFlddgtqqilpeVPWYGITVHDlrgLSEEEAEAALEELRERLSHRVLDVERGPLFD 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  670 VS-TQMPlRGRfHRdgagLHVALTMhhIAMDGQSIPVLARDLMSAYAARAEgrtgGLPVLDVQYADYALWQQsvlgdADD 748
Cdd:cd19535    116 IRlSLLP-EGR-TR----LHLSIDL--LVADALSLQILLRELAALYEDPGE----PLPPLELSFRDYLLAEQ-----ALR 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  749 ETSVLGEQlSHWRRVLAGLPAVTDLPMdRPRPAVLGTAGAT-VTVEFDDDLADRVDVLARSNTMTGFMVTEAAFAATVAR 827
Cdd:cd19535    179 ETAYERAR-AYWQERLPTLPPAPQLPL-AKDPEEIKEPRFTrREHRLSAEQWQRLKERARQHGVTPSMVLLTAYAEVLAR 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  828 LASTTDVVIGTPVAGRND--PALEELIGMFVNTLLLRTQVDPGHSVGDLLGNVRTTVLDAFAN-DQVQFDELIEALApeR 904
Cdd:cd19535    257 WSGQPRFLLNLTLFNRLPlhPDVNDVVGDFTSLLLLEVDGSEGQSFLERARRLQQQLWEDLDHsSYSGVVVVRRLLR--R 334

                          330
                   ....*....|...
gi 1827387616  905 SSSHQPLAQIAFT 917
Cdd:cd19535    335 RGGQPVLAPVVFT 347

PRK07768

long-chain-fatty-acid--CoA ligase; Validated

2587-2921

1.37e-10

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 66.94 E-value: 1.37e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2587 GAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYP----------AERVA 2656
Cdd:PRK07768    25 DAPVRHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRGASLTMLHQPTPrtdlavwaedTLRVI 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2657 SMIEDSGAVLGLSVLASGDLPGQEFEWMRLDDDSVAAEiaavPAGPItdaerlgEVTAANLAYVIYTSGSTGRPKGVAVT 2736
Cdd:PRK07768   105 GMIGAKAVVVGEPFLAAAPVLEEKGIRVLTVADLLAAD----PIDPV-------ETGEDDLALMQLTSGSTGSPKAVQIT 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2737 HSGLANFARQESDRLNAG-DNPVVLGFASPSFDASVLEYLLATVNEG--TLAYRPSEAVGGEVL-ERFIAEHGATHTF-- 2810
Cdd:PRK07768   174 HGNLYANAEAMFVAAEFDvETDVMVSWLPLFHDMGMVGFLTVPMYFGaeLVKVTPMDFLRDPLLwAELISKYRGTMTAap 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2811 -----LTPSVLSTMDPTA---VPSLRVIAAGGEAVPQPIVDRWAPATELHNL--------YGPTETTIGITIS------- 2867
Cdd:PRK07768   254 nfayaLLARRLRRQAKPGafdLSSLRFALNGAEPIDPADVEDLLDAGARFGLrpeailpaYGMAEATLAVSFSpcgaglv 333

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 2868 ---------SAMRPGDP---------VRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSG 2921
Cdd:PRK07768   334 vdevdadllAALRRAVPatkgntrrlATLGPPLPGLEVRVVDEDGQVLPPRGVGVIELRGESVTPGYLTMDG 405

PLN02479

acetate-CoA ligase

1050-1530

1.58e-10

acetate-CoA ligase

Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 66.79 E-value: 1.58e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1050 PDHPALICDGTEMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYML 1129
Cdd:PLN02479    34 PTRKSVVHGSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAVIAPNIPAMYEAHFGVPMAGAVVNCVNIRLNAPTIAFLL 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1130 EDSGATVGITD-------------------ASTRARL----GESSCEWVDLAD------LEAEA--ESGDDITD----TE 1174
Cdd:PLN02479   114 EHSKSEVVMVDqefftlaeealkilaekkkSSFKPPLliviGDPTCDPKSLQYalgkgaIEYEKflETGDPEFAwkppAD 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1175 RNGSVRLTnlayliYTSGSTGRPKAVGVSHTGIvdFVNSLAK-ITTGTPEDEPDTRILhvasPSFDASMFEMAWAIPA-G 1252
Cdd:PLN02479   194 EWQSIALG------YTSGTTASPKGVVLHHRGA--YLMALSNaLIWGMNEGAVYLWTL----PMFHCNGWCFTWTLAAlC 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1253 HTLVIAPQAdfAGDALATVLERDEVTDMIITPSVLATV----DPERA---QYVRNLATGGEACPPELVERWSERGRRIFN 1325
Cdd:PLN02479   262 GTNICLRQV--TAKAIYSAIANYGVTHFCAAPVVLNTIvnapKSETIlplPRVVHVMTAGAAPPPSVLFAMSEKGFRVTH 339

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1326 CYGPTE----ATVWA-----------TRSRMTAGKPVT-IGkpVDGFTVrVLDGRLHEVPQ--GVVGELYLSTAGLARGY 1387
Cdd:PLN02479   340 TYGLSEtygpSTVCAwkpewdslppeEQARLNARQGVRyIG--LEGLDV-VDTKTMKPVPAdgKTMGEIVMRGNMVMKGY 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1388 LGRPGQTAVSFVADpfgepgarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVES 1467
Cdd:PLN02479   417 LKNPKANEEAFANG--------WFHSGDLGVKHPDGYIEIKDRSKDIIISGGENISSLEVENVVYTHPAVLEASVVARPD 488

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1468 TRGGRKHtevVAYLVAKPGA-TIDSAAVLDEAAQ----HLAAHMVPsQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PLN02479   489 ERWGESP---CAFVTLKPGVdKSDEAALAEDIMKfcreRLPAYWVP-KSVVFGPLPKTATGKIQKHVL 552

PRK05850

acyl-CoA synthetase; Validated

1038-1416

1.97e-10

acyl-CoA synthetase; Validated

Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 66.50 E-value: 1.97e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1038 TLIDVLAQR-DLDPDHPALicdgTEMDYD-------------EFETRTNAIARALLARGvSPEDVVAVGMERSIGSVLAT 1103
Cdd:PRK05850     2 SVPSLLRERaSLQPDDAAF----TFIDYEqdpagvaetltwsQLYRRTLNVAEELRRHG-STGDRAVILAPQGLEYIVAF 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1104 WGVIKSGAAYVPVDPAYPA---DRIAYMLEDSGATVGITDASTRARLGESSCEW----------VDLADLEAEAESGDDI 1170
Cdd:PRK05850    77 LGALQAGLIAVPLSVPQGGahdERVSAVLRDTSPSVVLTTSAVVDDVTEYVAPQpgqsappvieVDLLDLDSPRGSDARP 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1171 TDterngsvrLTNLAYLIYTSGSTGRPKAVGVSHTG-IVDFVNSLAKITTGTPEDEPDTR--------------ILHVAS 1235
Cdd:PRK05850   157 RD--------LPSTAYLQYTSGSTRTPAGVMVSHRNvIANFEQLMSDYFGDTGGVPPPDTtvvswlpfyhdmglVLGVCA 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1236 PSFDAS----MFEMAW-AIPAG--HTLVIAPQA-----DFAGDaLATVLERDEvtDMiitpsvlATVDPERaqyVRNLAT 1303
Cdd:PRK05850   229 PILGGCpavlTSPVAFlQRPARwmQLLASNPHAfsaapNFAFE-LAVRKTSDD--DM-------AGLDLGG---VLGIIS 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1304 GGEACPPELVERWSERGRRiFN--------CYGPTEATVW------------------------ATRSRMTAGKP-VTIG 1350
Cdd:PRK05850   296 GSERVHPATLKRFADRFAP-FNlretairpSYGLAEATVYvatrepgqppesvrfdyeklsaghAKRCETGGGTPlVSYG 374

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827387616 1351 KPvDGFTVRVLDGRLH-EVPQGVVGELYLSTAGLARGYLGRPGQTAVSF---VADPF-GEPGARMYATGDL 1416
Cdd:PRK05850   375 SP-RSPTVRIVDPDTCiECPAGTVGEIWVHGDNVAAGYWQKPEETERTFgatLVDPSpGTPEGPWLRTGDL 444

PRK08279

long-chain-acyl-CoA synthetase; Validated

2-452

1.98e-10

long-chain-acyl-CoA synthetase; Validated

Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 66.44 E-value: 1.98e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVV--- 78
Cdd:PRK08279    64 SYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGAVVALLNTQQRGAVLAHSLNLVDAKHLIVgee 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   79 TSDGEAEARSRFDDIVDVHVLD----ISSPGDADLDEEEFAGPTRPANA---------AFTLFTSGSTGRPKAVVITHRG 145
Cdd:PRK08279   144 LVEAFEEARADLARPPRLWVAGgdtlDDPEGYEDLAAAAAGAPTTNPASrsgvtakdtAFYIYTSGTTGLPKAAVMSHMR 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  146 IANRLAADIEQYDLTARDVfLYkapitfdvsvreIFLP--------------IAIGATLVIaepGRHGDPVHLADLIRRH 211
Cdd:PRK08279   224 WLKAMGGFGGLLRLTPDDV-LY------------CCLPlyhntggtvawssvLAAGATLAL---RRKFSASRFWDDVRRY 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  212 GVTVIHFvpamlaafnevlgagVGELT---------------SLRLIQtgGEALTPPVARDLMVRLPGTRLQNQYGPAEA 276
Cdd:PRK08279   288 RATAFQY---------------IGELCryllnqppkptdrdhRLRLMI--GNGLRPDIWDEFQQRFGIPRILEFYAASEG 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  277 SIVV--------TIHRVTQDDRViPI---------GTPTRrvsarvlDAA--LREVPIGVPGELyLGGV-QLAR--GYAg 334
Cdd:PRK08279   351 NVGFinvfnfdgTVGRVPLWLAH-PYaivkydvdtGEPVR-------DADgrCIKVKPGEVGLL-IGRItDRGPfdGYT- 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  335 RPDLTAERFVADPFgEPGARLYRTGDRARWNRDGEIEY---LGRTdFQVKlrGQRLELGEVEAALAAAPGVLHAAAAVVD 411
Cdd:PRK08279   421 DPEASEKKILRDVF-KKGDAWFNTGDLMRDDGFGHAQFvdrLGDT-FRWK--GENVATTEVENALSGFPGVEEAVVYGVE 496

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616  412 GPG-----GQQLVGYLAPADVDVDTVAATTAELLPEYMRPsAWVRL 452
Cdd:PRK08279   497 VPGtdgraGMAAIVLADGAEFDLAALAAHLYERLPAYAVP-LFVRL 541

PRK05620

long-chain fatty-acid--CoA ligase;

1061-1530

2.17e-10

long-chain fatty-acid--CoA ligase;

Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 66.34 E-value: 2.17e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAIARALLAR-GVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT 1139
Cdd:PRK05620    38 QTTFAAIGARAAALAHALHDElGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEVIVA 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DASTRARLGE--SSCEWV---------DLADLEAEAESGDDITDTERNGSVRLT----------NLAYLIYTSGSTGRPK 1198
Cdd:PRK05620   118 DPRLAEQLGEilKECPCVravvfigpsDADSAAAHMPEGIKVYSYEALLDGRSTvydwpeldetTAAAICYSTGTTGAPK 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1199 AVGVSHTGIvdFVNSLAKITTGTPEDEPDTRIL------HVASpsfdasmfemaWAIP-----AGHTLVIaPQADFAGDA 1267
Cdd:PRK05620   198 GVVYSHRSL--YLQSLSLRTTDSLAVTHGESFLccvpiyHVLS-----------WGVPlaafmSGTPLVF-PGPDLSAPT 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1268 LATVLERDE------VTDMIITPSVLATVDPERAQYVRNLATGGEACPPELVERWSER-GRRIFNCYGPTEATVWATRSR 1340
Cdd:PRK05620   264 LAKIIATAMprvahgVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAVPPILIKAWEERyGVDVVHVWGMTETSPVGTVAR 343

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1341 MTAGKP--------VTIGKPVDGFTVRVL-DGRL---HEVPQG--------VVGELYLSTAGLARGYLGRPGQTAVSFVA 1400
Cdd:PRK05620   344 PPSGVSgearwayrVSQGRFPASLEYRIVnDGQVmesTDRNEGeiqvrgnwVTASYYHSPTEEGGGAASTFRGEDVEDAN 423

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1401 DPFGEPGarMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVay 1480
Cdd:PRK05620   424 DRFTADG--WLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIGYPDDKWGERPLAVT-- 499

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 1481 lVAKPGA--TIDSAAVL-DEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK05620   500 -VLAPGIepTRETAERLrDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDL 551

LC-FACS_euk

cd05927

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...

28-370

2.27e-10

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.

Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 66.08 E-value: 2.27e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   28 VGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGEAEArsrFDDIVDVhvldisspGDA 107
Cdd:cd05927     35 VGIYSINRPEWIISELACYAYSLVTVPLYDTLGPEAIEYILNHAEISIVFCDAGVKVYS---LEEFEKL--------GKK 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  108 DLDEEEfagPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQydltardVFLYKAPITFDVSVReiFLPIA-- 185
Cdd:cd05927    104 NKVPPP---PPKPEDLATICYTSGTTGNPKGVMLTHGNIVSNVAGVFKI-------LEILNKINPTDVYIS--YLPLAhi 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  186 ---IGATLVIAEPGR----HGDPVHLADLIRRHGVTVIHFVPAML-----AAFNEVLGAG--------------VGELTS 239
Cdd:cd05927    172 ferVVEALFLYHGAKigfySGDIRLLLDDIKALKPTVFPGVPRVLnriydKIFNKVQAKGplkrklfnfalnykLAELRS 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  240 ------------------------LRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIhrVTQDDRVI-PI 294
Cdd:cd05927    252 gvvraspfwdklvfnkikqalggnVRLMLTGSAPLSPEVLEFLRVAL-GCPVLEGYGQTECTAGATL--TLPGDTSVgHV 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  295 GTPTRRVSARVLDA------ALREVPigvPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDG 368
Cdd:cd05927    329 GGPLPCAEVKLVDVpemnydAKDPNP---RGEVCIRGPNVFSGYYKDPEKTAEALDEDGW-------LHTGDIGEWLPNG 398


                   ..
gi 1827387616  369 EI 370
Cdd:cd05927    399 TL 400

C_NRPS-like

cd19537

Condensation family domain with an atypical active site motif; Condensation (C) domains of ...

2140-2421

2.54e-10

Pssm-ID: 380460 [Multi-domain] Cd Length: 395 Bit Score: 65.28 E-value: 2.54e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2140 VLSLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAVTVVPAEVTVPW-SVIDLRAEdaasldsrveevlaterTN- 2217
Cdd:cd19537     29 ACRLSGDVDRDRLASAWNTVLARHRILRSRYVPRDGGLRRSYSSSPPRVQRvDTLDVWKE-----------------INr 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2218 PFDMAKPPLIRVVLvehgDGAELVVTNHHllidgwssplVLADLLSLYA----TGQTFTGSLPGTSGRDFADHARAVATA 2293
Cdd:cd19537     92 PFDLEREDPIRVFI----SPDTLLVVMSH----------IICDLTTLQLllreVSAAYNGKLLPPVRREYLDSTAWSRPA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2294 DVEAgIAAWREVLAPVteptlvapghePSADAPPRD---------HQFSIDVKVTERLEALARNNSTTM-----ATVvqf 2359
Cdd:cd19537    158 SPED-LDFWSEYLSGL-----------PLLNLPRRTssksyrgtsRVFQLPGSLYRSLLQFSTSSGITLhqlalAAV--- 222

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 2360 awAMFLSRLTGTRTVTFAETVSGRSPDIEgmESMVGMFINTIPAVV--DVNPDATVVDVLTAVQ 2421
Cdd:cd19537    223 --ALALQDLSDRTDIVLGAPYLNRTSEED--METVGLFLEPLPIRIrfPSSSDASAADFLRAVR 282

FATP_chFAT1_like

cd05937

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...

2593-3059

2.82e-10

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.

Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 65.53 E-value: 2.82e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2593 TYRELDEASDRLARWLIG-RGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIEDSGAVLGLSvl 2671
Cdd:cd05937      7 TYSETYDLVLRYAHWLHDdLGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAAPAFINYNLSGDPLIHCLKLSGSRFVIV-- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2672 asgdlpgqefewmrlDDDSVAAeiaavpagpitdaerlgevtaanlayVIYTSGSTGRPKGVAVTHSGLANFARQESDRL 2751
Cdd:cd05937     85 ---------------DPDDPAI--------------------------LIYTSGTTGLPKAAAISWRRTLVTSNLLSHDL 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAgDNPVVLGFASPSFDASVleYLLATVNE----GTLAYRPSEAVggevlERF---IAEHGATHTF----LTPSVLSTmd 2820
Cdd:cd05937    124 NL-KNGDRTYTCMPLYHGTA--AFLGACNClmsgGTLALSRKFSA-----SQFwkdVRDSGATIIQyvgeLCRYLLST-- 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2821 PtavPSL-----RVIAAGGEAVPQPIVDRWAP---ATELHNLYGPTETTIGITISSAmrpGD----PVRLGGPI------ 2882
Cdd:cd05937    194 P---PSPydrdhKVRVAWGNGLRPDIWERFRErfnVPEIGEFYAATEGVFALTNHNV---GDfgagAIGHHGLIrrwkfe 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2883 GGVDLMVLDER-----LRP-------VPVGMPGELYVAGGALSR----GYLDRSGLTAERFTANPYgTAGQRMYRTGDVV 2946
Cdd:cd05937    268 NQVVLVKMDPEtddpiRDPktgfcvrAPVGEPGEMLGRVPFKNReafqGYLHNEDATESKLVRDVF-RKGDIYFRTGDLL 346

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2947 RWtpdtDTGGLtLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV--------GGSVATAL---AAYIVPVD 3015
Cdd:cd05937    347 RQ----DADGR-WYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGVkvpghdgrAGCAAITLeesSAVPTEFT 421

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 3016 gaveVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:cd05937    422 ----KSLLASLARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVL 461

PLN03102

acyl-activating enzyme; Provisional

9-463

5.12e-10

acyl-activating enzyme; Provisional

Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 65.04 E-value: 5.12e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    9 RVTGLARELTALGVGAEVAVGIqIDRSVEQVVAIH-AVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGEAEAR 87
Cdd:PLN03102    48 RCCRLAASLISLNITKNDVVSV-LAPNTPAMYEMHfAVPMAGAVLNPINTRLDATSIAAILRHAKPKILFVDRSFEPLAR 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   88 ------SRFDDIVDVHVL---DISSPGDADLDEEEFAG------PTRPANAAFTL-----------FTSGSTGRPKAVVI 141
Cdd:PLN03102   127 evlhllSSEDSNLNLPVIfihEIDFPKRPSSEELDYECliqrgePTPSLVARMFRiqdehdpislnYTSGTTADPKGVVI 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  142 THRGIANRLAADIEQYDLTARDVFLYKAPI------TFDVSVreiflpIAIGATLVIAepgRHGDPVHLADLIRRHGVTV 215
Cdd:PLN03102   207 SHRGAYLSTLSAIIGWEMGTCPVYLWTLPMfhcngwTFTWGT------AARGGTSVCM---RHVTAPEIYKNIEMHNVTH 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  216 IHFVPAMlaaFNEVLGAGVGEL---TSLRLIQTGGEalTPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVI 292
Cdd:PLN03102   278 MCCVPTV---FNILLKGNSLDLsprSGPVHVLTGGS--PPPAALVKKVQRLGFQVMHAYGLTEATGPVLFCEWQDEWNRL 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  293 PIGTPTR---RVSARVL-----DAALREVPIGVP------GELYLGGVQLARGYAGRPDLTAERFVADpfgepgarLYRT 358
Cdd:PLN03102   353 PENQQMElkaRQGVSILgladvDVKNKETQESVPrdgktmGEIVIKGSSIMKGYLKNPKATSEAFKHG--------WLNT 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  359 GDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPG-GQQLVGYLA------PADVDVDT 431
Cdd:PLN03102   425 GDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTwGETPCAFVVlekgetTKEDRVDK 504

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1827387616  432 VAATTAEL-------LPEYMRPSAWVRLDAMPLSRSGKV 463
Cdd:PLN03102   505 LVTRERDLieycrenLPHFMCPRKVVFLQELPKNGNGKI 543

E-C_NRPS

cd19544

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); ...

617-879

5.67e-10

Pssm-ID: 380466 [Multi-domain] Cd Length: 413 Bit Score: 64.38 E-value: 5.67e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  617 VVERHEVLRTVYPSVG-AAPVQDV-----LPVavarEQLDWREADSVESLVRSTTEG----FDVsTQMPL-RGRFHRDGA 685
Cdd:cd19544     48 VIDRHDILRTAILWEGlSEPVQVVwrqaeLPV----EELTLDPGDDALAQLRARFDPrryrLDL-RQAPLlRAHVAEDPA 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  686 G--LHVALTMHHIAMDGQSIPVLARDLmsayAARAEGRTGGLPVLdVQYADYALWQQSVLGDADDETsvlgeqlsHWRRV 763
Cdd:cd19544    123 NgrWLLLLLFHHLISDHTSLELLLEEI----QAILAGRAAALPPP-VPYRNFVAQARLGASQAEHEA--------FFREM 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  764 LAG-----LP-AVTDLPMDrprpavlGTAGATVTVEFDDDLADRVDVLARSNTMTGFMVTEAAFAATVARLASTTDVVIG 837
Cdd:cd19544    190 LGDvdeptAPfGLLDVQGD-------GSDITEARLALDAELAQRLRAQARRLGVSPASLFHLAWALVLARCSGRDDVVFG 262

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1827387616  838 TPVAGR--NDPALEELIGMFVNTLLLRTQVDpGHSVGDLLGNVR 879
Cdd:cd19544    263 TVLSGRmqGGAGADRALGMFINTLPLRVRLG-GRSVREAVRQTH 305

EntF2

COG3319

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...

2572-3124

8.12e-10

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442548 [Multi-domain] Cd Length: 855 Bit Score: 64.72 E-value: 8.12e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2572 RAAARRAPDHVAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYP 2651
Cdd:COG3319      7 AAAAAAAAAAAAAAAAAAAALAAAAAAAAAAALLLLAAALLVALAALALAALALAALLAVALLAAALALAALAALAALAL 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2652 AERVASMIEDSGAVLGLSVLASGDLPGQEFEW--MRLDDDSVAAEIAAVPAGPITDAERLGEVTAANLAYVIYTSGSTGR 2729
Cdd:COG3319     87 ALAAAAAALLLAALALLLALLAALALALLALLlaALLLALAALAAAAAAAALAAAAAAAAALAAAAGLGGGGGGAGVLVL 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2730 PKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEGTLAYRPSEAVGGEVLERFIAEHGATHT 2809
Cdd:COG3319    167 VLAALLALLLAALLALALALAALLLLALAAALALALLLLLALLLLLLLLLALLLLLLLALLAAAALLALLLALLLLLLAA 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2810 FLTPSVLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWAPATELHNLYGPTETTIGITISSAMRPGDPVRLGGPIGGVDLMV 2889
Cdd:COG3319    247 LLLLLALALLLLLALLLLLGLLALLLALLLLLALLLLAAAAALAAGGTATTAAVTTTAAAAAPGVAGALGPIGGGPGLLV 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2890 LDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYGTAGQRMYRTGDVVRWTPDTDtGGLTLEYTGRSDDQV 2969
Cdd:COG3319    327 LLVLLVLLLPLLLGVGGGGGGGGGGGGAGGLAGRGLRAAAALRDPAGAGARGRLRRGGDRGRRL-GGGLLLGLGRLRLQR 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2970 KLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLT 3049
Cdd:COG3319    406 LRRGLREELEEAEAALAEAAAVAAAVAAAAAAAAAAAALAAAVVAAAALAAAALLLLLLLLLLPPPLPPALLLLLLLLLL 485

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 3050 PVGKLDKRALPEPVLEAGEYVAPATGTERTIADVAAGVLNIDAGLVSATSSFFEL------------------------- 3104
Cdd:COG3319    486 LLLAALLLAAAAPAAAAAAAAAPAPAAALELALALLLLLLLGLGLVGDDDDFFGGgggsllallllllllalllrlllll 565

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 3105 ---------------------------------------------GGDSLSAARLAARLSDQLGV 3124
Cdd:COG3319    566 alllaptlaalaaalaaaaaaaalsplvplraggsgpplfcvhpaGGNVLCYRPLARALGPDRPV 630

PRK05620

long-chain fatty-acid--CoA ligase;

2709-3059

9.05e-10

long-chain fatty-acid--CoA ligase;

Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 64.42 E-value: 9.05e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2709 LGEVTAANLAYviyTSGSTGRPKGVAVTHSGLAnfarQESDRLNAGDN-------------PV--VLGFASPsfdasvle 2773
Cdd:PRK05620   178 LDETTAAAICY---STGTTGAPKGVVYSHRSLY----LQSLSLRTTDSlavthgesflccvPIyhVLSWGVP-------- 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2774 ylLATVNEGTLAYRPSEAVGGEVLERFIAE------HGATHTFLTPSVLSTMDPTAVPSLRVIAAGGEAVPQPIVDRWAP 2847
Cdd:PRK05620   243 --LAAFMSGTPLVFPGPDLSAPTLAKIIATamprvaHGVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAVPPILIKAWEE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2848 --ATELHNLYGPTETTigiTISSAMRPgdPVRLGG-------------PIGGVDLMVLDERLRPVPVGMPGELYVAGGAL 2912
Cdd:PRK05620   321 ryGVDVVHVWGMTETS---PVGTVARP--PSGVSGearwayrvsqgrfPASLEYRIVNDGQVMESTDRNEGEIQVRGNWV 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2913 SRGYL----DRSGLTAERFTANPYGTAGQRM-----YRTGDVVRWTPDtdtGGLTLEytGRSDDQVKLRGLRIELGEIEA 2983
Cdd:PRK05620   396 TASYYhsptEEGGGAASTFRGEDVEDANDRFtadgwLRTGDVGSVTRD---GFLTIH--DRARDVIRSGGEWIYSAQLEN 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2984 VLAEHDAVESAVVLGVGGS-------VATALAAYIVPVDGAVEvsELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDK 3056
Cdd:PRK05620   471 YIMAAPEVVECAVIGYPDDkwgerplAVTVLAPGIEPTRETAE--RLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDK 548


                   ...
gi 1827387616 3057 RAL 3059
Cdd:PRK05620   549 KDL 551

ttLC_FACS_like

cd05915

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...

1061-1530

1.02e-09

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.

Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 63.99 E-value: 1.02e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAI--ARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGI 1138
Cdd:cd05915     22 VHRTTYAEVYQRARrlMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVLL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1139 TDASTRARLGESSCEWVDLADLEAEAESGDDITDTERNGS--------VRLTNLAYLIYTSGSTGRPKAVGVSHTGIvdF 1210
Cdd:cd05915    102 FDPNLLPLVEAIRGELKTVQHFVVMDEKAPEGYLAYEEALgeeadpvrVPERAACGMAYTTGTTGLPKGVVYSHRAL--V 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1211 VNSLAKITTGTPEDEPdTRILHVASPSFDASMFEMAWAIPAGHTLVIAPQADFAGDALATVLERDEVTDMIITPSVLATV 1290
Cdd:cd05915    180 LHSLAASLVDGTALSE-KDVVLPVVPMFHVNAWCLPYAATLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLAL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1291 DPERAQYVRNL-----ATGGEACPPELVERWSERGR-RIFNCYGPTE------ATVW-----------ATRSRMTAG--- 1344
Cdd:cd05915    259 ADYLESTGHRLktlrrLVVGGSAAPRSLIARFERMGvEVRQGYGLTEtspvvvQNFVkshleslseeeKLTLKAKTGlpi 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1345 --------KPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTAGLARGylgrpgqtavsfvadpfgepgaRMYATGDL 1416
Cdd:cd05915    339 plvrlrvaDEEGRPVPKDGKALGEVQLKGPWITGGYYGNEEATRSALTPD----------------------GFFRTGDI 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1417 VRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGvestRGGRKHTEVVAYLVAKPGATIDSAAVLD 1496
Cdd:cd05915    397 AVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVA----IPHPKWQERPLAVVVPRGEKPTPEELNE 472

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1827387616 1497 EAAQHLA-AHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:cd05915    473 HLLKAGFaKWQLPDAYVFAEEIPRTSAGKFLKRAL 507

ACS

cd05966

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...

1342-1527

1.07e-09

Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 64.12 E-value: 1.07e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1342 TAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTA--GLARGYLGRPGQtavsFVADPFGE-PGarMYATGDLVR 1418
Cdd:cd05966    405 TPLKPGSATRPFFGIEPAILDEEGNEVEGEVEGYLVIKRPwpGMARTIYGDHER----YEDTYFSKfPG--YYFTGDGAR 478

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1419 VAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIdSAAVLDEA 1498
Cdd:cd05966    479 RDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEA---IYAFVTLKDGEEP-SDELRKEL 554

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1827387616 1499 AQH----LAAHMVPSQAIVIDEIPLTPAGKLDR 1527
Cdd:cd05966    555 RKHvrkeIGPIATPDKIQFVPGLPKTRSGKIMR 587

PRK09192

fatty acyl-AMP ligase;

2592-2919

1.55e-09

fatty acyl-AMP ligase;

Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 63.49 E-value: 1.55e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2592 LTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDpdYPA---------ERVASMIEDS 2662
Cdd:PRK09192    50 LPYQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAGLVPVPLP--LPMgfggresyiAQLRGMLASA 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2663 GAVLGLSVLASGDLPGQEFEWMRLDDDSVAAEIAAVPAGPITdaerLGEVTAANLAYVIYTSGSTGRPKGVAVTH-SGLA 2741
Cdd:PRK09192   128 QPAAIITPDELLPWVNEATHGNPLLHVLSHAWFKALPEADVA----LPRPTPDDIAYLQYSSGSTRFPRGVIITHrALMA 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2742 NFARQESDRLN--AGDNPV----------VLGF--------------ASPSFDASVLEYL-LATVNEGTLAYRPSeaVGG 2794
Cdd:PRK09192   204 NLRAISHDGLKvrPGDRCVswlpfyhdmgLVGFlltpvatqlsvdylPTRDFARRPLQWLdLISRNRGTISYSPP--FGY 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2795 EVLERFIAEhgATHTFLTPSvlstmdptavpSLRVIAAGGEAVPQPI----VDRWAPA----TELHNLYGPTETTIGITI 2866
Cdd:PRK09192   282 ELCARRVNS--KDLAELDLS-----------CWRVAGIGADMIRPDVlhqfAEAFAPAgfddKAFMPSYGLAEATLAVSF 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2867 SS--------------------AMRPGDP-------VRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDR 2919
Cdd:PRK09192   349 SPlgsgivveevdrdrleyqgkAVAPGAEtrrvrtfVNCGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRD 428

A_NRPS_MycA_like

cd05908

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...

2703-3000

1.56e-09

Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 63.28 E-value: 1.56e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2703 ITDAERLGEVtAANLAYVIYTSGSTGRPKGVAVTHSGLANFARQESDRLNAGDNPVVLGFASPSFDASVLEYLLATVNEG 2782
Cdd:cd05908     95 ITEEEVLCEL-ADELAFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKDRILSWMPLTHDMGLIAFHLAPLIAG 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2783 TLAY---------RPSEAVggevleRFIAEHGATHT----FLTPSVLSTMDPTA-----VPSLRVIAAGGEAVPQPIVDR 2844
Cdd:cd05908    174 MNQYlmptrlfirRPILWL------KKASEHKATIVsspnFGYKYFLKTLKPEKandwdLSSIRMILNGAEPIDYELCHE 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2845 WAPATELHNL--------YGPTETTIGITISSAMRP-------------GDP--------------VRLGGPIGGVDLMV 2889
Cdd:cd05908    248 FLDHMSKYGLkrnailpvYGLAEASVGASLPKAQSPfktitlgrrhvthGEPepevdkkdsecltfVEVGKPIDETDIRI 327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2890 LDERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDV--VRwtpdtdTGGLTLeyTGRSDD 2967
Cdd:cd05908    328 CDEDNKILPDGYIGHIQIRGKNVTPGYYNNPEATAKVFTDDGW-------LKTGDLgfIR------NGRLVI--TGREKD 392

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1827387616 2968 QVKLRGLRIELGEIEAVLAEHDAVESAVVLGVG 3000
Cdd:cd05908    393 IIFVNGQNVYPHDIERIAEELEGVELGRVVACG 425

hsFATP2a_ACSVL_like

cd05938

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ...

1064-1511

1.96e-09

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 63.08 E-value: 1.96e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLA-RGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGITDAS 1142
Cdd:cd05938      8 YRDVDRRSNQAARALLAhAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKVLVVAPE 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1143 TRARL------------------GESSCEWVDlADLEAEAESGDDITDTERNGSVRLTNLAYLIYTSGSTGRPKAVGVSH 1204
Cdd:cd05938     88 LQEAVeevlpalradgvsvwylsHTSNTEGVI-SLLDKVDAASDEPVPASLRAHVTIKSPALYIYTSGTTGLPKAARISH 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1205 TGIV--DFVNSLAKITTgtpEDepdtrILHVASPSF--DASMFEMAWAIPAGHTLVIAPQadFAGDALATVLERDEVTDM 1280
Cdd:cd05938    167 LRVLqcSGFLSLCGVTA---DD-----VIYITLPLYhsSGFLLGIGGCIELGATCVLKPK--FSASQFWDDCRKHNVTVI 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1281 iitpsvlatvdperaQYVrnlatgGEAC------PPELVER----------------WSERGRR-----IFNCYGPTEAT 1333
Cdd:cd05938    237 ---------------QYI------GELLrylcnqPQSPNDRdhkvrlaignglradvWREFLRRfgpirIREFYGSTEGN 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1334 VwatrSRMT-AGKPVTIGK---------PVD--------GFTVRVLDGRLHEVPQGVVGELYLSTAGLA--RGYLGRPGQ 1393
Cdd:cd05938    296 I----GFFNyTGKIGAVGRvsylykllfPFElikfdvekEEPVRDAQGFCIPVAKGEPGLLVAKITQQSpfLGYAGDKEQ 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1394 TAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVesTRGGRK 1473
Cdd:cd05938    372 TEKKLLRDVF-KKGDVYFNTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVNVYGV--TVPGHE 448

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 1827387616 1474 HTEVVAYLVAKPGATIDsaavLDEAAQHLaAHMVPSQA 1511
Cdd:cd05938    449 GRIGMAAVKLKPGHEFD----GKKLYQHV-REYLPAYA 481

PLN02330

4-coumarate--CoA ligase-like 1

128-470

1.96e-09

4-coumarate--CoA ligase-like 1

Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 63.07 E-value: 1.96e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRGIANRLAADIEQY--DLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAEpGRHGDPVHLA 205
Cdd:PLN02330   191 FSSGTTGISKGVMLTHRNLVANLCSSLFSVgpEMIGQVVTLGLIPFFHIYGITGICCATLRNKGKVVVM-SRFELRTFLN 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 DLIRrHGVTVIHFVPAMLaaFNEVLGAGVGE--LTSLRL--IQTGGEALTPPVARDLMVRLPGTRLQNQYGPAEASIVVT 281
Cdd:PLN02330   270 ALIT-QEVSFAPIVPPII--LNLVKNPIVEEfdLSKLKLqaIMTAAAPLAPELLTAFEAKFPGVQVQEAYGLTEHSCITL 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  282 IHRVTQDDRVI----PIGTPTRRVSARVLDAAL-REVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlY 356
Cdd:PLN02330   347 THGDPEKGHGIakknSVGFILPNLEVKFIDPDTgRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIDEDGW-------L 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  357 RTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVVDGPggQQLVGYLAPADVDVDTVAATT 436
Cdd:PLN02330   420 HTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSV--EDAAVVPLP--DEEAGEIPAACVVINPKAKES 495

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1827387616  437 AELLPEYMRPSAW----VR----LDAMPLSRSGKVDRRLLPE 470
Cdd:PLN02330   496 EEDILNFVAANVAhykkVRvvqfVDSIPKSLSGKIMRRLLKE 537

PaaK

COG1541

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...

2723-2993

2.09e-09

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];

Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 62.86 E-value: 2.09e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2723 TSGSTGRPKGVAVTHSGLANFARQESdRL--NAGDNP---VVLGFAspsfdasvleYLLATVneGTLAYRPSEAVGGEVL 2797
Cdd:COG1541     91 SSGTTGKPTVVGYTRKDLDRWAELFA-RSlrAAGVRPgdrVQNAFG----------YGLFTG--GLGLHYGAERLGATVI 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2798 -------ER---FIAEHGATHTFLTPSVLSTM---------DPTAvPSLRVIAAGGEAVPQP----IVDRWApaTELHNL 2854
Cdd:COG1541    158 pagggntERqlrLMQDFGPTVLVGTPSYLLYLaevaeeegiDPRD-LSLKKGIFGGEPWSEEmrkeIEERWG--IKAYDI 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 YGPTETTIGITISSAMRPGdpvrlggpiggvdlMVLDERL-----------RPVPVGMPGELYVaggalsrgyldrSGLT 2923
Cdd:COG1541    235 YGLTEVGPGVAYECEAQDG--------------LHIWEDHflveiidpetgEPVPEGEEGELVV------------TTLT 288

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 2924 AE-----RftanpygtagqrmYRTGDVVRWTPDTDTGGLT---LEY-TGRSDDQVKLRGLRIELGEIEAVLAEHDAVES 2993
Cdd:COG1541    289 KEampliR-------------YRTGDLTRLLPEPCPCGRThprIGRiLGRADDMLIIRGVNVFPSQIEEVLLRIPEVGP 354

prpE

PRK10524

propionyl-CoA synthetase; Provisional

24-466

2.28e-09

propionyl-CoA synthetase; Provisional

Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 63.04 E-value: 2.28e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   24 AEVAVGIQIDRSvEQVVAIHAVA-MAGGHFVP----LDEQ-----------LPVDRA-RYMVRTAGvRLVvvtsDGEAEA 86
Cdd:PRK10524   144 ASHSLAARIDDA-KPVLIVSADAgSRGGKVVPykplLDEAialaqhkprhvLLVDRGlAPMARVAG-RDV----DYATLR 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   87 RSRFDDIVDVHVLDISSPgdadldeeefagptrpanaAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQ-YDLTARDVF 165
Cdd:PRK10524   218 AQHLGARVPVEWLESNEP-------------------SYILYTSGTTGKPKGVQRDTGGYAVALATSMDTiFGGKAGETF 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  166 LYKAPITFDVSVREI-FLPIAIGATLVIAEpgrhGDPVH-----LADLIRRHGVTVIHFVPA---MLAAFNEVLgAGVGE 236
Cdd:PRK10524   279 FCASDIGWVVGHSYIvYAPLLAGMATIMYE----GLPTRpdagiWWRIVEKYKVNRMFSAPTairVLKKQDPAL-LRKHD 353

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 LTSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASI-VVTIHRvTQDDRVIPIGTPTRRV---SARVLDAALRE 312
Cdd:PRK10524   354 LSSLRALFLAGEPLDEPTASWISEAL-GVPVIDNYWQTETGWpILAIAR-GVEDRPTRLGSPGVPMygyNVKLLNEVTGE 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  313 VP-------IGVPGELYLGGVQLARGyagrpdlTAERFVADPFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQ 385
Cdd:PRK10524   432 PCgpnekgvLVIEGPLPPGCMQTVWG-------DDDRFVKTYWSLFGRQVYSTFDWGIRDADGYYFILGRTDDVINVAGH 504

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  386 RLELGEVEAALAAAPGVlhAAAAVV---DGPGGQQLVGYLAPADVDVDTVAATTAELLPEYM-----------RPSAWVR 451
Cdd:PRK10524   505 RLGTREIEESISSHPAV--AEVAVVgvkDALKGQVAVAFVVPKDSDSLADREARLALEKEIMalvdsqlgavaRPARVWF 582

                          490
                   ....*....|....*
gi 1827387616  452 LDAMPLSRSGKVDRR 466
Cdd:PRK10524   583 VSALPKTRSGKLLRR 597

LC-FACS_euk

cd05927

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...

2713-3013

2.49e-09

Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 63.00 E-value: 2.49e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2713 TAANLAYVIYTSGSTGRPKGVAVTH----SGLANFARQESDRLNAGDNPVVLGFASPS--FDASVLEYLLA--------- 2777
Cdd:cd05927    112 KPEDLATICYTSGTTGNPKGVMLTHgnivSNVAGVFKILEILNKINPTDVYISYLPLAhiFERVVEALFLYhgakigfys 191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2778 ----TVNEGTLAYRPS-------------EAVGGEV-----LERFI-------------AEHGATHTFLTPSVLSTMDPT 2822
Cdd:cd05927    192 gdirLLLDDIKALKPTvfpgvprvlnriyDKIFNKVqakgpLKRKLfnfalnyklaelrSGVVRASPFWDKLVFNKIKQA 271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2823 AVPSLRVIAAGGEAVPQPIVD--RWAPATELHNLYGPTETTIGITISsamRPGDPV--RLGGPIGGVDLmvldeRLRPVP 2898
Cdd:cd05927    272 LGGNVRLMLTGSAPLSPEVLEflRVALGCPVLEGYGQTECTAGATLT---LPGDTSvgHVGGPLPCAEV-----KLVDVP 343

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2899 -----VGMP---GELYVAGGALSRGYLDRSGLTAERFTANPYgtagqrmYRTGDVVRWTPDtdtGGLTLeyTGRSDDQVK 2970
Cdd:cd05927    344 emnydAKDPnprGEVCIRGPNVFSGYYKDPEKTAEALDEDGW-------LHTGDIGEWLPN---GTLKI--IDRKKNIFK 411

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 2971 L-RGLRIELGEIEAVLAEHDAVESAVVLgvGGSVATALAAYIVP 3013
Cdd:cd05927    412 LsQGEYVAPEKIENIYARSPFVAQIFVY--GDSLKSFLVAIVVP 453

AACS

cd05943

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...

2556-3053

2.65e-09

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.

Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 63.06 E-value: 2.65e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2556 VTGGPATDPV-----TL--AE--LFRAAARRAPDHVAVVDGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRS 2626
Cdd:cd05943     54 VSGRIMPGARwfpgaRLnyAEnlLRHADADDPAAIYAAEDGERTEVTWAELRRRVARLAAALRALGVKPGDRVAGYLPNI 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2627 AQLLTAIWAVAKTGGAYVPIDPDYPAERVA---SMIE------DSGAV---------------------LGLSVLASGDL 2676
Cdd:cd05943    134 PEAVVAMLATASIGAIWSSCSPDFGVPGVLdrfGQIEpkvlfaVDAYTyngkrhdvrekvaelvkglpsLLAVVVVPYTV 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2677 PGQEFEWMRLDDDSVAAEIAAVPAGPITDAERLGevtAANLAYVIYTSGSTGRPKGVAVTHSG-----LANFARQeSDrL 2751
Cdd:cd05943    214 AAGQPDLSKIAKALTLEDFLATGAAGELEFEPLP---FDHPLYILYSSGTTGLPKCIVHGAGGtllqhLKEHILH-CD-L 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGD-------------NPVVLGFASpsfDASVLEYllatvnEGTLAYRPseavgGEVLERFIAEHGATH-----TFLTP 2813
Cdd:cd05943    289 RPGDrlfyyttcgwmmwNWLVSGLAV---GATIVLY------DGSPFYPD-----TNALWDLADEEGITVfgtsaKYLDA 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2814 SVLSTMDPTAV---PSLRVIAAGGEAVPQP----IVDRWAPATELHNLYGPTETtigITISSAMRPGDPVRLG---GPIG 2883
Cdd:cd05943    355 LEKAGLKPAEThdlSSLRTILSTGSPLKPEsfdyVYDHIKPDVLLASISGGTDI---ISCFVGGNPLLPVYRGeiqCRGL 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2884 GVDLMVLDERLRPVpVGMPGELYVAGGALSR-----GYLDRSGLTAERFTANPygtagqRMYRTGDVVRWTPDtdtGGLT 2958
Cdd:cd05943    432 GMAVEAFDEEGKPV-WGEKGELVCTKPFPSMpvgfwNDPDGSRYRAAYFAKYP------GVWAHGDWIEITPR---GGVV 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2959 LeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGV---GGSVATALaaYIVPVDGAVEVSEL-----KAFAGGR 3030
Cdd:cd05943    502 I--LGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLVVGQewkDGDERVIL--FVKLREGVELDDELrkrirSTIRSAL 577

                          570       580
                   ....*....|....*....|...
gi 1827387616 3031 LPAYmVPSSFTVIDELPLTPVGK 3053
Cdd:cd05943    578 SPRH-VPAKIIAVPDIPRTLSGK 599

FATP_chFAT1_like

cd05937

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...

1184-1465

3.69e-09

Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 62.06 E-value: 3.69e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1184 LAYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDEpdtriLHVASPSFDASMFEMAWA--IPAGHTLVIAPQ- 1260
Cdd:cd05937     89 PAILIYTSGTTGLPKAAAISWRRTLVTSNLLSHDLNLKNGDR-----TYTCMPLYHGTAAFLGACncLMSGGTLALSRKf 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1261 --ADFAGDALAT----VLERDEVTDMIItpSVLATVDpERAQYVRnLATGgEACPPELVERWSERgrriFNC------YG 1328
Cdd:cd05937    164 saSQFWKDVRDSgatiIQYVGELCRYLL--STPPSPY-DRDHKVR-VAWG-NGLRPDIWERFRER----FNVpeigefYA 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1329 PTEATVWAT---RSRMTAGK-----------------PVTIG--------KPVDGFTVRVLDGRlhevPQGVVGELYLST 1380
Cdd:cd05937    235 ATEGVFALTnhnVGDFGAGAighhglirrwkfenqvvLVKMDpetddpirDPKTGFCVRAPVGE----PGEMLGRVPFKN 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1381 AGLARGYLGRPGQTAVSFVADPFgEPGARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQS 1460
Cdd:cd05937    311 REAFQGYLHNEDATESKLVRDVF-RKGDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEA 389


                   ....*
gi 1827387616 1461 VVVGV 1465
Cdd:cd05937    390 NVYGV 394

PRK08043

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

1185-1535

4.13e-09

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 62.42 E-value: 4.13e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1185 AYLIYTSGSTGRPKAVGVSHTGIVDFVNSLAKITTGTPEDepdtRILHvASPSFDASMFEMAWAIP--AGHTLVIAPQAD 1262
Cdd:PRK08043   368 ALILFTSGSEGHPKGVVHSHKSLLANVEQIKTIADFTPND----RFMS-ALPLFHSFGLTVGLFTPllTGAEVFLYPSPL 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1263 FAGDALATVLERDeVTDMIITPSVLATV-------DPERAQYVrnlATGGEACPPELVERWSER-GRRIFNCYGPTE-AT 1333
Cdd:PRK08043   443 HYRIVPELVYDRN-CTVLFGTSTFLGNYarfanpyDFARLRYV---VAGAEKLQESTKQLWQDKfGLRILEGYGVTEcAP 518

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1334 VWATRSRMtAGKPVTIGKPVDGftvrvLDGRLHEVP---QGvvGELYLSTAGLARGYL--GRPGQTAVSFVADPFGEPGA 1408
Cdd:PRK08043   519 VVSINVPM-AAKPGTVGRILPG-----MDARLLSVPgieQG--GRLQLKGPNIMNGYLrvEKPGVLEVPTAENARGEMER 590

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1409 RMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAV-LDAQPGVAQSVVVGVESTRGgrkhTEVVAYlvakpga 1487
Cdd:PRK08043   591 GWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLaLGVSPDKQHATAIKSDASKG----EALVLF------- 659

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1488 TIDSAAVLDEAAQHLAAHMVPSQAI-----VIDEIPLTPAGKLDRAAL------PEPHA 1535
Cdd:PRK08043   660 TTDSELTREKLQQYAREHGVPELAVprdirYLKQLPLLGSGKPDFVTLksmvdePEQHD 718

PRK08162

acyl-CoA synthetase; Validated

4-413

4.46e-09

acyl-CoA synthetase; Validated

Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 61.89 E-value: 4.46e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVtsDGE 83
Cdd:PRK08162    47 AETYARCRRLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPMAGAVLNTLNTRLDAASIAFMLRHGEAKVLIV--DTE 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 -----AEARSRFD--DIVDVHVLDISSPGDA---DLDEEEFA-------GPTRPANA--AFTL-FTSGSTGRPKAVVITH 143
Cdd:PRK08162   125 faevaREALALLPgpKPLVIDVDDPEYPGGRfigALDYEAFLasgdpdfAWTLPADEwdAIALnYTSGTTGNPKGVVYHH 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  144 RGIANRLAADIEQYDLTARDVFLYKAPI------TFDVSVreiflpIAIGATLVIAepgRHGDPVHLADLIRRHGVTviH 217
Cdd:PRK08162   205 RGAYLNALSNILAWGMPKHPVYLWTLPMfhcngwCFPWTV------AARAGTNVCL---RKVDPKLIFDLIREHGVT--H 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  218 F-----VPAMLAAFNEVLGAGVGELTSlrlIQTGGEAltPPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVTQDDRVI 292
Cdd:PRK08162   274 YcgapiVLSALINAPAEWRAGIDHPVH---AMVAGAA--PPAAVIAKMEEIGFDLTHVYGLTETYGPATVCAWQPEWDAL 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  293 PIGTPTRRVS-----------ARVLDAA-LREVP-----IgvpGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarl 355
Cdd:PRK08162   349 PLDERAQLKArqgvryplqegVTVLDPDtMQPVPadgetI---GEIMFRGNIVMKGYLKNPKATEEAFAGGWF------- 418

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616  356 yRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLhaAAAVVDGP 413
Cdd:PRK08162   419 -HTGDLAVLHPDGYIKIKDRSKDIIISGGENISSIEVEDVLYRHPAVL--VAAVVAKP 473

PKS_PP

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...

3080-3142

4.68e-09

Pssm-ID: 214834 [Multi-domain] Cd Length: 86 Bit Score: 55.72 E-value: 4.68e-09

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616  3080 IADVAAGVLNIDAG-LVSATSSFFELGGDSLSAARLAARLSDQLGVAVSVRDVFESGSIRALAE 3142
Cdd:smart00823   17 VREQVAAVLGHAAAeAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAE 80

FCS

cd05921

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...

2-363

4.84e-09

Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 62.06 E-value: 4.84e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPV-----DRARYMVRTAGVRLV 76
Cdd:cd05921     27 TYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPVSPAYSLmsqdlAKLKHLFELLKPGLV 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   77 VVtSDGEAEARSrFDDIVDVHVLDISSPGDAD----------------LDEEEFAGPTRPANAAFTLFTSGSTGRPKAVV 140
Cdd:cd05921    107 FA-QDAAPFARA-LAAIFPLGTPLVVSRNAVAgrgaisfaelaatpptAAVDAAFAAVGPDTVAKFLFTSGSTGLPKAVI 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  141 ITHRGIANRLAADIEQYDLTARD--VFLYKAPITFDVSVREIFLPIAI-GATLVIAE----PGRHGDPVhlaDLIRRHGV 213
Cdd:cd05921    185 NTQRMLCANQAMLEQTYPFFGEEppVLVDWLPWNHTFGGNHNFNLVLYnGGTLYIDDgkpmPGGFEETL---RNLREISP 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  214 TVIHFVPA---MLAAF---NEVLGAGVgeLTSLRLIQTGGEALTPPV---ARDLMVRLPGTRLQ--NQYGPAEASIVVT- 281
Cdd:cd05921    262 TVYFNVPAgweMLVAAlekDEALRRRF--FKRLKLMFYAGAGLSQDVwdrLQALAVATVGERIPmmAGLGATETAPTATf 339

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  282 IHRVTqdDRVIPIGTPTRRVsarvldaALREVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDR 361
Cdd:cd05921    340 THWPT--ERSGLIGLPAPGT-------ELKLVPSGGKYEVRVKGPNVTPGYWRQPELTAQAFDEEGF-------YCLGDA 403


                   ..
gi 1827387616  362 AR 363
Cdd:cd05921    404 AK 405

PRK06334

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

120-468

6.46e-09

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 61.37 E-value: 6.46e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  120 PANAAFTLFTSGSTGRPKAVVITHRG-IANRLAAdIEQYDLTARDVFLYKAP----ITFDVSVreiFLPIAIGATLVIAE 194
Cdd:PRK06334   182 PEDVAVILFTSGTEKLPKGVPLTHANlLANQRAC-LKFFSPKEDDVMMSFLPpfhaYGFNSCT---LFPLLSGVPVVFAY 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  195 PGRHgdPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELTSLRLIQTGGEALTPPVARDLMVRLPGTRLQNQYGPA 274
Cdd:PRK06334   258 NPLY--PKKIVEMIDEAKVTFLGSTPVFFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIQLRQGYGTT 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  275 EASIVVTIHRVTQDDRVIPIGTPTRRVSARVLDAALR-EVPIGVPGELYLGGVQLARGYAGrpdltaerfvADP---FGE 350
Cdd:PRK06334   336 ECSPVITINTVNSPKHESCVGMPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYLG----------EDFgqgFVE 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  351 -PGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALA---AAPGVLHAAAAVVDG-PGGQQLVGYLAPA 425
Cdd:PRK06334   406 lGGETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILMegfGQNAADHAGPLVVCGlPGEKVRLCLFTTF 485

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616  426 DVDVDTV-----AATTAELlpeyMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK06334   486 PTSISEVndilkNSKTSSI----LKISYHHQVESIPMLGTGKPDYCSL 529

PRK06710

long-chain-fatty-acid--CoA ligase; Validated

4-472

6.73e-09

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 61.59 E-value: 6.73e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLV-----VV 78
Cdd:PRK06710    53 SVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGIVVQTNPLYTERELEYQLHDSGAKVIlcldlVF 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   79 TSDGEAEARSRFDDIVDVHVLD-ISSPGDA--------------------------DLDEEEFAG---PTRPAN-AAFTL 127
Cdd:PRK06710   133 PRVTNVQSATKIEHVIVTRIADfLPFPKNLlypfvqkkqsnlvvkvsesetihlwnSVEKEVNTGvevPCDPENdLALLQ 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRG-IANRLAADIEQYD-LTARDVFLYKAPITFDVSVREIF-LPIAIGATLVIAEpgrHGDPVHL 204
Cdd:PRK06710   213 YTGGTTGFPKGVMLTHKNlVSNTLMGVQWLYNcKEGEEVVLGVLPFFHVYGMTAVMnLSIMQGYKMVLIP---KFDMKMV 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  205 ADLIRRHGVTVIHFVPAM-LAAFNEVLGAGVgELTSLRLIQTGGEALtPPVARDLMVRLPGTRLQNQYGPAEASIVVtiH 283
Cdd:PRK06710   290 FEAIKKHKVTLFPGAPTIyIALLNSPLLKEY-DISSIRACISGSAPL-PVEVQEKFETVTGGKLVEGYGLTESSPVT--H 365

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  284 RVTQDDRVIP--IGTPTRRVSARVLDAALREV-PIGVPGELYLGGVQLARGYAGRPDLTAErFVADPFgepgarlYRTGD 360
Cdd:PRK06710   366 SNFLWEKRVPgsIGVPWPDTEAMIMSLETGEAlPPGEIGEIVVKGPQIMKGYWNKPEETAA-VLQDGW-------LHTGD 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  361 RARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGP-GGQQLVGYLAPADVDV---DTVAATT 436
Cdd:PRK06710   438 VGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKVQEVVTIGVPDPyRGETVKAFVVLKEGTEcseEELNQFA 517

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 1827387616  437 AELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPE 472
Cdd:PRK06710   518 RKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEEE 553

prpE

PRK10524

propionyl-CoA synthetase; Provisional

2719-3059

7.39e-09

propionyl-CoA synthetase; Provisional

Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 61.50 E-value: 7.39e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2719 YVIYTSGSTGRPKGVAVTHSGLAnFARQESDRLNAGDNPVVLGFASPSFDASV---------LEYLLATV-NEGtLAYRP 2788
Cdd:PRK10524   237 YILYTSGTTGKPKGVQRDTGGYA-VALATSMDTIFGGKAGETFFCASDIGWVVghsyivyapLLAGMATImYEG-LPTRP 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2789 SEAVGGEVLERfiaeHGATHTFLTPS---VLSTMDPTA-----VPSLRVIAAGGE------------AVPQPIVDRwapa 2848
Cdd:PRK10524   315 DAGIWWRIVEK----YKVNRMFSAPTairVLKKQDPALlrkhdLSSLRALFLAGEpldeptaswiseALGVPVIDN---- 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2849 telhnlYGPTETtiGITISSAMRPGD--PVRLGGP---IGGVDLMVLDERL-RPVPVGMPGELYVAG----GALSRGYLD 2918
Cdd:PRK10524   387 ------YWQTET--GWPILAIARGVEdrPTRLGSPgvpMYGYNVKLLNEVTgEPCGPNEKGVLVIEGplppGCMQTVWGD 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2919 RsgltaERFTANPYGTAGQRMYRTGDvvrWTPDTDTGGLTLeyTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLG 2998
Cdd:PRK10524   459 D-----DRFVKTYWSLFGRQVYSTFD---WGIRDADGYYFI--LGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVG 528

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 2999 VG----GSVATALAayiVPVDGAVEVSELKAFA---------GGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK10524   529 VKdalkGQVAVAFV---VPKDSDSLADREARLAlekeimalvDSQLGAVARPARVWFVSALPKTRSGKLLRRAI 599

PRK08180

feruloyl-CoA synthase; Reviewed

1061-1513

8.37e-09

feruloyl-CoA synthase; Reviewed

Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 61.43 E-value: 8.37e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAY---PAD--RIAYMLE----- 1130
Cdd:PRK08180    69 RLTYAEALERVRAIAQALLDRGLSAERPLMILSGNSIEHALLALAAMYAGVPYAPVSPAYslvSQDfgKLRHVLElltpg 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1131 ----DSGA----------TVGITDASTRARLGESSCewVDLADLEAEAESGDDitdTERNGSVRLTNLAYLIYTSGSTGR 1196
Cdd:PRK08180   149 lvfaDDGAafaralaavvPADVEVVAVRGAVPGRAA--TPFAALLATPPTAAV---DAAHAAVGPDTIAKFLFTSGSTGL 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1197 PKAVGVSHTGIVdfVNSLAKITT-GTPEDEPdTRILHVA--SPSFDASM-FEMAWA------------IPAG--HTL--- 1255
Cdd:PRK08180   224 PKAVINTHRMLC--ANQQMLAQTfPFLAEEP-PVLVDWLpwNHTFGGNHnLGIVLYnggtlyiddgkpTPGGfdETLrnl 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1256 -VIAPQADF---AG-DALATVLERDEvtdmiitpsVLATVDPERaqyVRNLATGGEACPPEL---VERWSER--GRRIFN 1325
Cdd:PRK08180   301 rEISPTVYFnvpKGwEMLVPALERDA---------ALRRRFFSR---LKLLFYAGAALSQDVwdrLDRVAEAtcGERIRM 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1326 C--YGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVldgrlheVPQGvvGELYLSTAG--LARGYLGRPGQTAVSFVAD 1401
Cdd:PRK08180   369 MtgLGMTETAPSATFTTGPLSRAGNIGLPAPGCEVKL-------VPVG--GKLEVRVKGpnVTPGYWRAPELTAEAFDEE 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1402 PFgepgarmYATGDLVRVA------KGgnLEFAGRADHQVKI-NGQRVELGEIEA-VLDAQPGVAQSVVVgvestrGGRK 1473
Cdd:PRK08180   440 GY-------YRSGDAVRFVdpadpeRG--LMFDGRIAEDFKLsSGTWVSVGPLRArAVSAGAPLVQDVVI------TGHD 504

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1827387616 1474 HTEVVAYLVAKPGAtidSAAVLDEAAQHLAAHMVPSQAIV 1513
Cdd:PRK08180   505 RDEIGLLVFPNLDA---CRRLAGLLADASLAEVLAHPAVR 541

PLN03102

acyl-activating enzyme; Provisional

1187-1530

8.68e-09

acyl-activating enzyme; Provisional

Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 61.19 E-value: 8.68e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1187 LIYTSGSTGRPKAVGVSHTGIvdFVNSLAKITTGTPEDEPdtrILHVASPSFDASMFEMAWAIPA-GHT-----LVIAPQ 1260
Cdd:PLN03102   191 LNYTSGTTADPKGVVISHRGA--YLSTLSAIIGWEMGTCP---VYLWTLPMFHCNGWTFTWGTAArGGTsvcmrHVTAPE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1261 adfagdaLATVLERDEVTDMIITPSVL-------ATVDPERAQYVRNLaTGGEACPPELVERWSERGRRIFNCYGPTEAT 1333
Cdd:PLN03102   266 -------IYKNIEMHNVTHMCCVPTVFnillkgnSLDLSPRSGPVHVL-TGGSPPPAALVKKVQRLGFQVMHAYGLTEAT 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1334 ------VWATR-SRMTAGKPVTIG--KPVDGFTVRVLDGR----LHEVPQG--VVGELYLSTAGLARGYLGRPGQTAVSF 1398
Cdd:PLN03102   338 gpvlfcEWQDEwNRLPENQQMELKarQGVSILGLADVDVKnketQESVPRDgkTMGEIVIKGSSIMKGYLKNPKATSEAF 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1399 VADPFGepgarmyaTGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHtevV 1478
Cdd:PLN03102   418 KHGWLN--------TGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETP---C 486

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 1479 AYLVAKPGATIDSAAV----------LDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PLN03102   487 AFVVLEKGETTKEDRVdklvtrerdlIEYCRENLPHFMCPRKVVFLQELPKNGNGKILKPKL 548

PRK08308

acyl-CoA synthetase; Validated

1407-1531

9.90e-09

acyl-CoA synthetase; Validated

Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 60.44 E-value: 9.90e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1407 GARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVV-GVESTRGGRkhteVVAYLVAKp 1485
Cdd:PRK08308   289 GDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYrGKDPVAGER----VKAKVISH- 363

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1827387616 1486 gATIDSAAVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGKLDRAALP 1531
Cdd:PRK08308   364 -EEIDPVQLREWCIQHLAPYQVPHEIESVTEIPKNANGKVSRKLLE 408

LC_FACS_bac1

cd17641

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...

1061-1464

1.46e-08

Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 60.51 E-value: 1.46e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1061 EMDYDEFETRTNAIARALLARGVSPEDVVAV-GMERS--IGSVLATWGViksGAAYVPVDPAYPADRIAYMLEDSGATVG 1137
Cdd:cd17641     11 EFTWADYADRVRAFALGLLALGVGRGDVVAIlGDNRPewVWAELAAQAI---GALSLGIYQDSMAEEVAYLLNYTGARVV 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1138 IT-DASTRARLGE-----SSCEWV-----------------DLADLEAEAESGDDITDTERNGSVRLT---NLAYLIYTS 1191
Cdd:cd17641     88 IAeDEEQVDKLLEiadriPSVRYViycdprgmrkyddprliSFEDVVALGRALDRRDPGLYEREVAAGkgeDVAVLCTTS 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1192 GSTGRPKAVGVSHTG----------------------------IVDFVNSLAK-ITTGT----PEdEPDT---------- 1228
Cdd:cd17641    168 GTTGKPKLAMLSHGNflghcaaylaadplgpgdeyvsvlplpwIGEQMYSVGQaLVCGFivnfPE-EPETmmedlreigp 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1229 -----------------RILHVASPSFDASMFEmaWAIPAGHtlviapqadfagDALATVLERDEVTDMIITPSVLA--- 1288
Cdd:cd17641    247 tfvllpprvwegiaadvRARMMDATPFKRFMFE--LGMKLGL------------RALDRGKRGRPVSLWLRLASWLAdal 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1289 TVDPERAQ----YVRNLATGGEACPPELVERWSERGRRIFNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVLDgr 1364
Cdd:cd17641    313 LFRPLRDRlgfsRLRSAATGGAALGPDTFRFFHAIGVPLKQLYGQTELAGAYTVHRDGDVDPDTVGVPFPGTEVRIDE-- 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1365 lhevpqgvVGELYLSTAGLARGYLGRPGQTAVSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRA-DHQVKINGQRVE 1443
Cdd:cd17641    391 --------VGEILVRSPGVFVGYYKNPEATAEDFDEDGW-------LHTGDAGYFKENGHLVVIDRAkDVGTTSDGTRFS 455

                          490       500
                   ....*....|....*....|.
gi 1827387616 1444 LGEIEAVLDAQPGVAQSVVVG 1464
Cdd:cd17641    456 PQFIENKLKFSPYIAEAVVLG 476

PRK07008

long-chain-fatty-acid--CoA ligase; Validated

113-470

2.35e-08

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 59.72 E-value: 2.35e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  113 EFAGPTRPANAAFTL-FTSGSTGRPKAVVITHRG--IANRLAADIEQYDLTARDVFLYKAPItFDVSVREIFLPIAI-GA 188
Cdd:PRK07008   167 DYDWPRFDENQASSLcYTSGTTGNPKGALYSHRStvLHAYGAALPDAMGLSARDAVLPVVPM-FHVNAWGLPYSAPLtGA 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  189 TLVIaePGRHGDPVHLADLIRRHGVTVIHFVPAM-LAAFNEVLGAGVgELTSLRLIQTGGEALTPPVARDLMVRLpGTRL 267
Cdd:PRK07008   246 KLVL--PGPDLDGKSLYELIEAERVTFSAGVPTVwLGLLNHMREAGL-RFSTLRRTVIGGSACPPAMIRTFEDEY-GVEV 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  268 QNQYGPAEASIVVTIHRVTQDDRVIPI----------GTPTRRVSARVLDAALREVPI-GVP-GELYLGGVQLARGYAGR 335
Cdd:PRK07008   322 IHAWGMTEMSPLGTLCKLKWKHSQLPLdeqrkllekqGRVIYGVDMKIVGDDGRELPWdGKAfGDLQVRGPWVIDRYFRG 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  336 PdltaerfvADPFGEpgaRLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAA-------- 407
Cdd:PRK07008   402 D--------ASPLVD---GWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACiacahpkw 470

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616  408 ------AVVDGPGgqqlvgylapADVdvdtvaaTTAELLPEYMRPSA-W------VRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK07008   471 derpllVVVKRPG----------AEV-------TREELLAFYEGKVAkWwipddvVFVDAIPHTATGKLQKLKLRE 529

PP-binding

pfam00550

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...

1552-1607

2.47e-08

Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 52.57 E-value: 2.47e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1552 LARIVAGLLG--EERVSVTESFFALGGDSIMSIQLSSAAKAA-GIHLSPREIFELKTIR 1607
Cdd:pfam00550    3 LRELLAEVLGvpAEEIDPDTDLFDLGLDSLLAVELIARLEEEfGVEIPPSDLFEHPTLA 61

PRK07824

o-succinylbenzoate--CoA ligase;

319-468

2.82e-08

o-succinylbenzoate--CoA ligase;

Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 58.90 E-value: 2.82e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  319 GELYLGGVQLARGYAGRPDltaerfvADPFGEPGarLYRTGDRARWNrDGEIEYLGRTDFQVKLRGQRLELGEVEAALAA 398
Cdd:PRK07824   208 GRIALGGPTLAKGYRNPVD-------PDPFAEPG--WFRTDDLGALD-DGVLTVLGRADDAISTGGLTVLPQVVEAALAT 277

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616  399 APGVlhAAAAVVDGPG---GQQLVGYLAPADVDVDTVAATTAEL---LPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK07824   278 HPAV--ADCAVFGLPDdrlGQRVVAAVVGDGGPAPTLEALRAHVartLDRTAAPRELHVVDELPRRGIGKVDRRAL 351

FCS

cd05921

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...

1064-1464

3.10e-08

Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 59.37 E-value: 3.10e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPA-----DRIAYMLE-------- 1130
Cdd:cd05921     28 YAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPVSPAYSLmsqdlAKLKHLFEllkpglvf 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1131 --------DSGATVGITD----ASTRARLGESSCEWVDLADLEAEAESgdditdTERNGSVRLTNLAYLIYTSGSTGRPK 1198
Cdd:cd05921    108 aqdaapfaRALAAIFPLGtplvVSRNAVAGRGAISFAELAATPPTAAV------DAAFAAVGPDTVAKFLFTSGSTGLPK 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1199 AVGVSHTGIVdfVNSLAKITTGTPEDEPDTRILHVA--SPSFDASM-FEM------AWAIPAGHTLV------------I 1257
Cdd:cd05921    182 AVINTQRMLC--ANQAMLEQTYPFFGEEPPVLVDWLpwNHTFGGNHnFNLvlynggTLYIDDGKPMPggfeetlrnlreI 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1258 APQADF---AG-DALATVLERDEVTdmiitpsvlatvdpeRAQYVRNL---ATGGEACPPELVERWSE-----RGRRI-- 1323
Cdd:cd05921    260 SPTVYFnvpAGwEMLVAALEKDEAL---------------RRRFFKRLklmFYAGAGLSQDVWDRLQAlavatVGERIpm 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1324 FNCYGPTEATVWATRSRMTAGKPVTIGKPVDGFTVRVldgrlheVPQGVVGELYLSTAGLARGYLGRPGQTAVSFVADPF 1403
Cdd:cd05921    325 MAGLGATETAPTATFTHWPTERSGLIGLPAPGTELKL-------VPSGGKYEVRVKGPNVTPGYWRQPELTAQAFDEEGF 397

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1404 gepgarmYATGDLVRVA------KGgnLEFAGRADHQVKIN-GQRVELGEI--EAVLDAQPGVAQSVVVG 1464
Cdd:cd05921    398 -------YCLGDAAKLAdpddpaKG--LVFDGRVAEDFKLAsGTWVSVGPLraRAVAACAPLVHDAVVAG 458

PRK09029

O-succinylbenzoic acid--CoA ligase; Provisional

4-468

3.13e-08

O-succinylbenzoic acid--CoA ligase; Provisional

Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 59.11 E-value: 3.13e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    4 AEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVVTSDGE 83
Cdd:PRK09029    32 QQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQPLLEELLPSLTLDFALVLEGEN 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   84 AearsrFDDIVDVHVLDISSPGDADLDeeefagPTRPAnaafTL-FTSGSTGRPKAVVITHRG-IANrlAADI-EQYDLT 160
Cdd:PRK09029   112 T-----FSALTSLHLQLVEGAHAVAWQ------PQRLA----TMtLTSGSTGLPKAAVHTAQAhLAS--AEGVlSLMPFT 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  161 ARDVFLYKAPItFDVSVREIF---LpiAIGATLVIaepgrhGDPVHLADLIRrhGVTVIHFVPAMLaafnEVLGAGVGEL 237
Cdd:PRK09029   175 AQDSWLLSLPL-FHVSGQGIVwrwL--YAGATLVV------RDKQPLEQALA--GCTHASLVPTQL----WRLLDNRSEP 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  238 TSLRLIQTGGEALtpPVARDLMVRLPGTRLQNQYGPAEASIVVTIHRVtqdDRVIPIGTPTrrvsarvldaALREVPIgV 317
Cdd:PRK09029   240 LSLKAVLLGGAAI--PVELTEQAEQQGIRCWCGYGLTEMASTVCAKRA---DGLAGVGSPL----------PGREVKL-V 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  318 PGELYLGGVQLARGY--AGRP-DLTAERfvadpfGepgarLYRTGDRARWNrDGEIEYLGRTDFQVKLRGQRLELGEVEA 394
Cdd:PRK09029   304 DGEIWLRGASLALGYwrQGQLvPLVNDE------G-----WFATRDRGEWQ-NGELTILGRLDNLFFSGGEGIQPEEIER 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  395 ALAAAPGVLHA-AAAVVDGPGGQQlvgylaPADVdVDTVAATTAELLPEYM--------RPSAWVRLDAMpLSRSG-KVD 464
Cdd:PRK09029   372 VINQHPLVQQVfVVPVADAEFGQR------PVAV-VESDSEAAVVNLAEWLqdklarfqQPVAYYLLPPE-LKNGGiKIS 443


                   ....
gi 1827387616  465 RRLL 468
Cdd:PRK09029   444 RQAL 447

PRK09192

fatty acyl-AMP ligase;

1064-1529

4.19e-08

fatty acyl-AMP ligase;

Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 58.86 E-value: 4.19e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1064 YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAayVPVDPAYPA---------DRIAYMLEDSGA 1134
Cdd:PRK09192    52 YQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAGL--VPVPLPLPMgfggresyiAQLRGMLASAQP 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1135 TVGIT---------DASTRARLGESscewVDLADLEAEAESGDDITDTERNgsvrltNLAYLIYTSGSTGRPKAVGVSHT 1205
Cdd:PRK09192   130 AAIITpdellpwvnEATHGNPLLHV----LSHAWFKALPEADVALPRPTPD------DIAYLQYSSGSTRFPRGVIITHR 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1206 GIvdfVNSLAKITTGTPEDEPDTRILhvaspsfdasmfemAWaIPAGHT-----LVIAPQA-----------DFAGDALA 1269
Cdd:PRK09192   200 AL---MANLRAISHDGLKVRPGDRCV--------------SW-LPFYHDmglvgFLLTPVAtqlsvdylptrDFARRPLQ 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1270 --TVLERDEVTdMIITPSV-------------LATVDPERAqyvRNLATGGEACPPEL----VERWSERG--RRIF-NCY 1327
Cdd:PRK09192   262 wlDLISRNRGT-ISYSPPFgyelcarrvnskdLAELDLSCW---RVAGIGADMIRPDVlhqfAEAFAPAGfdDKAFmPSY 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1328 GPTEATVWAT--------------RSRMTAGKP--------------VTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLS 1379
Cdd:PRK09192   338 GLAEATLAVSfsplgsgivveevdRDRLEYQGKavapgaetrrvrtfVNCGKALPGHEIEIRNEAGMPLPERVVGHICVR 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1380 TAGLARGYLGRPgQTAVSFVADPFGEpgarmyaTGDLVRVAkGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGV-A 1458
Cdd:PRK09192   418 GPSLMSGYFRDE-ESQDVLAADGWLD-------TGDLGYLL-DGYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELrS 488

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 1459 QSVVVGVESTRGGRKhteVVAYLVAKPGATIDSAAVLDEAAQHL-AAHMVPSQAIVI--DEIPLTPAGKLDRAA 1529
Cdd:PRK09192   489 GDAAAFSIAQENGEK---IVLLVQCRISDEERRGQLIHALAALVrSEFGVEAAVELVppHSLPRTSSGKLSRAK 559

PRK08315

AMP-binding domain protein; Validated

128-375

4.40e-08

AMP-binding domain protein; Validated

Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 59.05 E-value: 4.40e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRGIAN--RLAAdiEQYDLTARD-----VFLYK---------APITFdvsvreiflpiaiGATLV 191
Cdd:PRK08315   206 YTSGTTGFPKGATLTHRNILNngYFIG--EAMKLTEEDrlcipVPLYHcfgmvlgnlACVTH-------------GATMV 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  192 IaePGRHGDPVHLADLIRRHGVTVIHFVPAMLAA------FNEVlgagvgELTSLRliqTGGEALTP---PVARDLMVRL 262
Cdd:PRK08315   271 Y--PGEGFDPLATLAAVEEERCTALYGVPTMFIAeldhpdFARF------DLSSLR---TGIMAGSPcpiEVMKRVIDKM 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  263 PGTRLQNQYGPAEASIVVTIHRVtqDD----RVIPIGTPTRRVSARVLDAAL-REVPIGVPGELYLGGVQLARGYAGRPD 337
Cdd:PRK08315   340 HMSEVTIAYGMTETSPVSTQTRT--DDplekRVTTVGRALPHLEVKIVDPETgETVPRGEQGELCTRGYSVMKGYWNDPE 417

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1827387616  338 LTAErfVADPfgepgARLYRTGDRARWNRDGEIEYLGR 375
Cdd:PRK08315   418 KTAE--AIDA-----DGWMHTGDLAVMDEEGYVNIVGR 448

PRK08308

acyl-CoA synthetase; Validated

2934-3060

4.47e-08

acyl-CoA synthetase; Validated

Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 58.51 E-value: 4.47e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2934 TAGQRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATALAAYIVP 3013
Cdd:PRK08308   287 KMGDKEIFTKDLGYKSERG-----TLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKAKVI 361

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1827387616 3014 VDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRALP 3060
Cdd:PRK08308   362 SHEEIDPVQLREWCIQHLAPYQVPHEIESVTEIPKNANGKVSRKLLE 408

AcpP

COG0236

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...

1543-1607

5.97e-08

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis

Pssm-ID: 440006 [Multi-domain] Cd Length: 80 Bit Score: 52.16 E-value: 5.97e-08

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616 1543 APANPAEDNLARIVAGLLG--EERVSVTESFFA-LGGDSIMSIQLSSAAKAA-GIHLSPREIFELKTIR 1607
Cdd:COG0236      1 MPREELEERLAEIIAEVLGvdPEEITPDDSFFEdLGLDSLDAVELIAALEEEfGIELPDTELFEYPTVA 69

AACS

cd05943

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...

1346-1524

7.42e-08

Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 58.44 E-value: 7.42e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1346 PVTIG---KPVDGFTVRVLDGRLHEVPqGVVGELYLstaglARGYLGRPgqtaVSFVADPFGE----------PGarMYA 1412
Cdd:cd05943    420 PVYRGeiqCRGLGMAVEAFDEEGKPVW-GEKGELVC-----TKPFPSMP----VGFWNDPDGSryraayfakyPG--VWA 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1413 TGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGrkhTEVVAYLVAKPGATIDSA 1492
Cdd:cd05943    488 HGDWIEITPRGGVVILGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLVVGQEWKDGD---ERVILFVKLREGVELDDE 564

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1827387616 1493 ---AVLDEAAQHLAAHMVPSQAIVIDEIPLTPAGK 1524
Cdd:cd05943    565 lrkRIRSTIRSALSPRHVPAKIIAVPDIPRTLSGK 599

PRK08180

feruloyl-CoA synthase; Reviewed

1-364

8.08e-08

feruloyl-CoA synthase; Reviewed

Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 57.97 E-value: 8.08e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQ---LPVDRA--RYMVRTAGVRL 75
Cdd:PRK08180    70 LTYAEALERVRAIAQALLDRGLSAERPLMILSGNSIEHALLALAAMYAGVPYAPVSPAyslVSQDFGklRHVLELLTPGL 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   76 VVVtSDGEAEARSrFDDIVDVHVLDISS----PGDADLDEEEFAGPTRPAN--AAF----------TLFTSGSTGRPKAV 139
Cdd:PRK08180   150 VFA-DDGAAFARA-LAAVVPADVEVVAVrgavPGRAATPFAALLATPPTAAvdAAHaavgpdtiakFLFTSGSTGLPKAV 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  140 VITHRgianRLAADIEQYDLTARDvFLYKAPITFDvsvreiFLP--------------IAIGATLVIAE----PGRhgdp 201
Cdd:PRK08180   228 INTHR----MLCANQQMLAQTFPF-LAEEPPVLVD------WLPwnhtfggnhnlgivLYNGGTLYIDDgkptPGG---- 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  202 vhLADLIR--RHGVTVIHF-VPA---MLAAF---NEVLGAGVgeLTSLRLIQTGGEALTPPVARDLM---VRLPGTRLQ- 268
Cdd:PRK08180   293 --FDETLRnlREISPTVYFnVPKgweMLVPAlerDAALRRRF--FSRLKLLFYAGAALSQDVWDRLDrvaEATCGERIRm 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  269 -NQYGPAEASIVVT-IHRvtQDDRVIPIGTPTRRVSARVldaalreVPIGVPGELYLGGVQLARGYAGRPDLTAERFVAD 346
Cdd:PRK08180   369 mTGLGMTETAPSATfTTG--PLSRAGNIGLPAPGCEVKL-------VPVGGKLEVRVKGPNVTPGYWRAPELTAEAFDEE 439

                          410
                   ....*....|....*...
gi 1827387616  347 PFgepgarlYRTGDRARW 364
Cdd:PRK08180   440 GY-------YRSGDAVRF 450

PRK05857

fatty acid--CoA ligase;

1042-1530

8.92e-08

fatty acid--CoA ligase;

Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 57.71 E-value: 8.92e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1042 VLAQRDLDPDHPALI-CDGT-EMDYDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPA 1119
Cdd:PRK05857    20 VFEQARQQPEAIALRrCDGTsALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGN 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1120 YPADRIAYMLEdsgatvgITDAST-----RARLGESSCEWVDLADLEAEAESGDDITDTERNGSVRL--TNLAY------ 1186
Cdd:PRK05857   100 LPIAAIERFCQ-------ITDPAAalvapGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASlaGNADQgsedpl 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1187 -LIYTSGSTGRPKAVGVSHTGI-----------VDFVNSLAKITTGTPedEPDTRIlhvaspsfdASMFEMAWAIPAGHT 1254
Cdd:PRK05857   173 aMIFTSGTTGEPKAVLLANRTFfavpdilqkegLNWVTWVVGETTYSP--LPATHI---------GGLWWILTCLMHGGL 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1255 LVIAPQadfAGDALATVLERDEVTDMIITPSVL----------ATVDPEraqyVRNLATGGEACPPELVERWSERGRRIF 1324
Cdd:PRK05857   242 CVTGGE---NTTSLLEILTTNAVATTCLVPTLLsklvselksaNATVPS----LRLVGYGGSRAIAADVRFIEATGVRTA 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1325 NCYGPTEATVWA--------TRSRMTAGkpvTIGKPVDGFTVRVL--DGRLHEVPQGV----VGELYLSTAGLARGYLGR 1390
Cdd:PRK05857   315 QVYGLSETGCTAlclptddgSIVKIEAG---AVGRPYPGVDVYLAatDGIGPTAPGAGpsasFGTLWIKSPANMLGYWNN 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1391 PGQTAvSFVADPFgepgarmYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRG 1470
Cdd:PRK05857   392 PERTA-EVLIDGW-------VNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEF 463

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616 1471 GrkhteVVAYLVAKPGATIDSAAVLdEAAQHLAAH--------MVPSQAIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK05857   464 G-----ALVGLAVVASAELDESAAR-ALKHTIAARfrresepmARPSTIVIVTDIPRTQSGKVMRASL 525

PLN02387

long-chain-fatty-acid-CoA ligase family protein

61-405

1.13e-07

long-chain-fatty-acid-CoA ligase family protein

Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 57.82 E-value: 1.13e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   61 VDRARYMvRTAGVRLVVVTSDGEAEARSRFDDivdVHVLDISSPGDADLdeeefagpTRPANAAFTLFTSGSTGRPKAVV 140
Cdd:PLN02387   202 VKRVIYM-DDEGVDSDSSLSGSSNWTVSSFSE---VEKLGKENPVDPDL--------PSPNDIAVIMYTSGSTGLPKGVM 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  141 ITHRGIANRLAADIEQY-DLTARDVFLykapitfdvsvreIFLPIA----IGATLVIAEPGR---HGDPVHLADL---IR 209
Cdd:PLN02387   270 MTHGNIVATVAGVMTVVpKLGKNDVYL-------------AYLPLAhileLAAESVMAAVGAaigYGSPLTLTDTsnkIK 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  210 RH--------GVTVIHFVPAML-----------------------AAFNEVLGA------GVGELTSL------------ 240
Cdd:PLN02387   337 KGtkgdasalKPTLMTAVPAILdrvrdgvrkkvdakgglakklfdIAYKRRLAAiegswfGAWGLEKLlwdalvfkkira 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  241 ------RLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRVtqDDrvipigTPTRRVSARVLDAALREV- 313
Cdd:PLN02387   417 vlggriRFMLSGGAPLSGDTQRFINICL-GAPIGQGYGLTETCAGATFSEW--DD------TSVGRVGPPLPCCYVKLVs 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  314 -PIG--------VP-GELYLGGVQLARGYAGRPDLTAERFVADpfgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLR 383
Cdd:PLN02387   488 wEEGgylisdkpMPrGEIVIGGPSVTLGYFKNQEKTDEVYKVD---ERGMRWFYTGDIGQFHPDGCLEIIDRKKDIVKLQ 564

                          410       420
                   ....*....|....*....|....*..
gi 1827387616  384 -GQRLELGEVEAALAAAPGV----LHA 405
Cdd:PLN02387   565 hGEYVSLGKVEAALSVSPYVdnimVHA 591

prpE

PRK10524

propionyl-CoA synthetase; Provisional

1043-1530

1.26e-07

propionyl-CoA synthetase; Provisional

Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 57.65 E-value: 1.26e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1043 LAQRdldPDHPALICDGTEMD------YDEFETRTNAIARALLARGVSPEDVVAVGMERSIGSVLATWGVIKSGAAYVPV 1116
Cdd:PRK10524    63 LAKR---PEQLALIAVSTETDeertytFRQLHDEVNRMAAMLRSLGVQRGDRVLIYMPMIAEAAFAMLACARIGAIHSVV 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1117 DPAYPADRIAYMLEDSGATVGIT-DASTRA--------------RLGESSCEWVDLAD---LEAEAESGDDI---TDTER 1175
Cdd:PRK10524   140 FGGFASHSLAARIDDAKPVLIVSaDAGSRGgkvvpykplldeaiALAQHKPRHVLLVDrglAPMARVAGRDVdyaTLRAQ 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1176 NGSVRL-------TNLAYLIYTSGSTGRPKAVgVSHTG--IVDFVNSLAKITTGTPEDepdtrilhvaspsfdaSMF--- 1243
Cdd:PRK10524   220 HLGARVpvewlesNEPSYILYTSGTTGKPKGV-QRDTGgyAVALATSMDTIFGGKAGE----------------TFFcas 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1244 EMAWAIpaGHTLVI-APQadFAGdaLATVL-----------------ERDEVTDMIITPS---VLATVDPER-AQY---- 1297
Cdd:PRK10524   283 DIGWVV--GHSYIVyAPL--LAG--MATIMyeglptrpdagiwwrivEKYKVNRMFSAPTairVLKKQDPALlRKHdlss 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1298 VRNLATGGEacpP--ELVERW--SERGRRIFNCYGPTEaTVW-----ATRSRMTAGKPVTIGKPVDGFTVRVLDGRLHEV 1368
Cdd:PRK10524   357 LRALFLAGE---PldEPTASWisEALGVPVIDNYWQTE-TGWpilaiARGVEDRPTRLGSPGVPMYGYNVKLLNEVTGEP 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1369 PQ----GVVGelylstaglARGYLgRPG--QTA----VSFVADPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQVKIN 1438
Cdd:PRK10524   433 CGpnekGVLV---------IEGPL-PPGcmQTVwgddDRFVKTYWSLFGRQVYSTFDWGIRDADGYYFILGRTDDVINVA 502

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1439 GQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVAKPGATIDS--------AAVLDEAAQHLAAHMVPSQ 1510
Cdd:PRK10524   503 GHRLGTREIEESISSHPAVAEVAVVGVKDALKGQV---AVAFVVPKDSDSLADrearlaleKEIMALVDSQLGAVARPAR 579

                          570       580
                   ....*....|....*....|
gi 1827387616 1511 AIVIDEIPLTPAGKLDRAAL 1530
Cdd:PRK10524   580 VWFVSALPKTRSGKLLRRAI 599

SgcC5_NRPS-like

cd19539

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

1642-1950

1.33e-07

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 57.00 E-value: 1.33e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1642 WMIEHSEEPAdfADFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDG----WTMNAGAGIVPAVREIDAEG 1717
Cdd:cd19539     12 WFIDQGEDGG--PAYNIPGAWRLTGPLDVEALREALRDVVARHEALRTLLVRDDGGvprqEILPPGPAPLEVRDLSDPDS 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1718 ALDPALVDAHRELLGAMDPGTGSLLGTAVV--NGEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEA 1795
Cdd:cd19539     90 DRERRLEELLRERESRGFDLDEEPPIRAVLgrFDPDDHVLVLVAHHTAFDAWSLDVFARDLAALYAARRKGPAAPLPELR 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1796 TTTRRIA-----HLLAGQVharAREVDYWLEQLPE-RPTSFGTSADRPLHRRRDESSLTYVVDDVAGSILTTVPQAFGSS 1869
Cdd:cd19539    170 QQYKEYAawqreALAAPRA---AELLDFWRRRLRGaEPTALPTDRPRPAGFPYPGADLRFELDAELVAALRELAKRARSS 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1870 VDDVLLGALARAVRAW--QLDngiadggpVTVSTEGHGRDESiagdegaiDLSRTVGWFTSITPLAVDASS-----DVVH 1942
Cdd:cd19539    247 LFMVLLAAYCVLLRRYtgQTD--------IVVGTPVAGRNHP--------RFESTVGFFVNLLPLRVDVSDcatfrDLIA 310


                   ....*....
gi 1827387616 1943 AV-KSAKDA 1950
Cdd:cd19539    311 RVrKALVDA 319

PLN02574

4-coumarate--CoA ligase-like

2716-3059

1.36e-07

4-coumarate--CoA ligase-like

Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 57.16 E-value: 1.36e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 NLAYVIYTSGSTGRPKGVAVTHSGLAN----FARQESDRLNAGDNPVVLGFASPSFDAsvleYLLATVNEGTLA------ 2785
Cdd:PLN02574   199 DVAAIMYSSGTTGASKGVVLTHRNLIAmvelFVRFEASQYEYPGSDNVYLAALPMFHI----YGLSLFVVGLLSlgstiv 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2786 ----YRPSEAVggEVLERFiaehGATHTFLTPSVLSTMDPTAVP-------SLRVIAAGGEAVPQPIVDRWA---PATEL 2851
Cdd:PLN02574   275 vmrrFDASDMV--KVIDRF----KVTHFPVVPPILMALTKKAKGvcgevlkSLKQVSCGAAPLSGKFIQDFVqtlPHVDF 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2852 HNLYGPTETTIGITI---SSAMRPGDPVRLGGPigGVDLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDRSGLTAERF 2927
Cdd:PLN02574   349 IQGYGMTESTAVGTRgfnTEKLSKYSSVGLLAP--NMQAKVVDwSTGCLLPPGNCGELWIQGPGVMKGYLNNPKATQSTI 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2928 TANPYgtagqrmYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGSVATAL 3007
Cdd:PLN02574   427 DKDGW-------LRTGDIAYFDEDG-----YLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEI 494

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 3008 -AAYIVPVDG-AVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PLN02574   495 pVAFVVRRQGsTLSQEAVINYVAKQVAPYKKVRKVVFVQSIPKSPAGKILRREL 548

PRK12476

putative fatty-acid--CoA ligase; Provisional

5-466

1.54e-07

putative fatty-acid--CoA ligase; Provisional

Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 57.06 E-value: 1.54e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEV-AVGIQIDR--------------SVEQVVAIHAVAMAGGHFVPL-DEQLP--VDRARY 66
Cdd:PRK12476    57 DHSHSAAGCAVELTWTQLGVRLrAVGARLQQvagpgdrvailapqGIDYVAGFFAAIKAGTIAVPLfAPELPghAERLDT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   67 MVRTAGVRLVVVTSDGEAEARSRFDDIVDV---HVLDISSPGDADldEEEFAGPTRPANA-AFTLFTSGSTGRPKAVVIT 142
Cdd:PRK12476   137 ALRDAEPTVVLTTTAAAEAVEGFLRNLPRLrrpRVIAIDAIPDSA--GESFVPVELDTDDvSHLQYTSGSTRPPVGVEIT 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  143 HRGIANRLAADIEQYDLTARDVF-LYKAPITFDVSVREIFLPIAIGATLVIAEPgrhgdpvhlADLIRRHGVTV------ 215
Cdd:PRK12476   215 HRAVGTNLVQMILSIDLLDRNTHgVSWLPLYHDMGLSMIGFPAVYGGHSTLMSP---------TAFVRRPQRWIkalseg 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  216 IHFVPAMLAAFNEVLgagvgELTSLRLIQTGGEAL----------TPPVARDLMVR---------LPGTRLQNQYGPAEA 276
Cdd:PRK12476   286 SRTGRVVTAAPNFAY-----EWAAQRGLPAEGDDIdlsnvvliigSEPVSIDAVTTfnkafapygLPRTAFKPSYGIAEA 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  277 SIVV-TIH---------------------RVTQD-DRVIP---IGTPTRRVSARVLDAAL-REVPIGVPGELYLGGVQLA 329
Cdd:PRK12476   361 TLFVaTIApdaepsvvyldreqlgagravRVAADaPNAVAhvsCGQVARSQWAVIVDPDTgAELPDGEVGEIWLHGDNIG 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  330 RGYAGRPDLTAERFVAD-----PFG------EPGARLYRTGDRARWnRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAA 398
Cdd:PRK12476   441 RGYWGRPEETERTFGAKlqsrlAEGshadgaADDGTWLRTGDLGVY-LDGELYITGRIADLIVIDGRNHYPQDIEATVAE 519

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  399 APGVL---HAAAAVVDGPGGQQLV--GYLAPADVDVD---TVAATTAELLPEYMRPSAWVRL---DAMPLSRSGKVDRR 466
Cdd:PRK12476   520 ASPMVrrgYVTAFTVPAEDNERLVivAERAAGTSRADpapAIDAIRAAVSRRHGLAVADVRLvpaGAIPRTTSGKLARR 598

PRK05857

fatty acid--CoA ligase;

1-468

1.75e-07

fatty acid--CoA ligase;

Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 56.94 E-value: 1.75e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    1 MSRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLP---VDRARYMVRTAGVrlvV 77
Cdd:PRK05857    42 LRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPiaaIERFCQITDPAAA---L 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   78 VTSDGEAEARSRFDDIVDVHVLDISSPGDA-----DLDEEEFAG-PTRPANAAFTL-FTSGSTGRPKAVVITHR---GIA 147
Cdd:PRK05857   119 VAPGSKMASSAVPEALHSIPVIAVDIAAVTresehSLDAASLAGnADQGSEDPLAMiFTSGTTGEPKAVLLANRtffAVP 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  148 NRLAAD-IEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIAepGRHGdpVHLADLIRRHGVTVIHFVPAMLAAF 226
Cdd:PRK05857   199 DILQKEgLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLCVTG--GENT--TSLLEILTTNAVATTCLVPTLLSKL 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  227 NEVLGAGVGELTSLRLIQTGGealTPPVARDL-MVRLPGTRLQNQYGPAEASIVV--------TIHRVTQDdrviPIGTP 297
Cdd:PRK05857   275 VSELKSANATVPSLRLVGYGG---SRAIAADVrFIEATGVRTAQVYGLSETGCTAlclptddgSIVKIEAG----AVGRP 347

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  298 TRRVSARVLDA--ALREVPIGVP----GELYLGGVQLARGYAGRPDLTAErFVADPFgepgarlYRTGDRARWNRDGEIE 371
Cdd:PRK05857   348 YPGVDVYLAATdgIGPTAPGAGPsasfGTLWIKSPANMLGYWNNPERTAE-VLIDGW-------VNTGDLLERREDGFFY 419

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  372 YLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGY--LAPADVDVDTVAATTAELLPEY------ 443
Cdd:PRK05857   420 IKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLavVASAELDESAARALKHTIAARFrresep 499

                          490       500
                   ....*....|....*....|....*.
gi 1827387616  444 -MRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PRK05857   500 mARPSTIVIVTDIPRTQSGKVMRASL 525

PLN02654

acetate-CoA ligase

2587-3059

1.83e-07

acetate-CoA ligase

Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 57.21 E-value: 1.83e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2587 GAGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERVASMIED----- 2661
Cdd:PLN02654   116 GFDASLTYSELLDRVCQLANYLKDVGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDckpkv 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2662 ----SGAVLGLSVLASGDLPGQEFEWMRLDDDSVAAEIA------------------------AVPAGPIT-DAERlgeV 2712
Cdd:PLN02654   196 vitcNAVKRGPKTINLKDIVDAALDESAKNGVSVGICLTyenqlamkredtkwqegrdvwwqdVVPNYPTKcEVEW---V 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2713 TAANLAYVIYTSGSTGRPKGVAVTHSGLA---------NFARQESD-RLNAGDNPVVLGFASPSFdASVLEYLLATVNEG 2782
Cdd:PLN02654   273 DAEDPLFLLYTSGSTGKPKGVLHTTGGYMvytattfkyAFDYKPTDvYWCTADCGWITGHSYVTY-GPMLNGATVLVFEG 351

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2783 TLAYrPSEAVGGEVLERFIAEHGATHTFLTPSVLSTMDPTAV----PSLRVIAAGGEAVpQPIVDRWapateLHNLYGPT 2858
Cdd:PLN02654   352 APNY-PDSGRCWDIVDKYKVTIFYTAPTLVRSLMRDGDEYVTrhsrKSLRVLGSVGEPI-NPSAWRW-----FFNVVGDS 424

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2859 ETTIG------------ITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAG---GALSRGYLDRSGLT 2923
Cdd:PLN02654   425 RCPISdtwwqtetggfmITPLPGAWPQKPGSATFPFFGVQPVIVDEKGKEIEGECSGYLCVKKswpGAFRTLYGDHERYE 504

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2924 AERFTANP-YGTAGQRMYRTGDVVRWtpdtdtggltleYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVESAVVLGVGGS 3002
Cdd:PLN02654   505 TTYFKPFAgYYFSGDGCSRDKDGYYW------------LTGRVDDVINVSGHRIGTAEVESALVSHPQCAEAAVVGIEHE 572

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616 3003 V-ATALAAYIVPVDGAVEVSELKA----FAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PLN02654   573 VkGQGIYAFVTLVEGVPYSEELRKslilTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRIL 634

PRK07769

long-chain-fatty-acid--CoA ligase; Validated

5-409

2.85e-07

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 181109 [Multi-domain] Cd Length: 631 Bit Score: 56.28 E-value: 2.85e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    5 EFDRRVTGLARELTALGVGAEV-AVGIQI-------DR-------SVEQVVAIHAVAMAGGHFVPL-DEQLP--VDRARy 66
Cdd:PRK07769    44 DFSTERDGVARDLTWSQFGARNrAVGARLqqvtkpgDRvailapqNLDYLIAFFGALYAGRIAVPLfDPAEPghVGRLH- 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   67 MVRTAGVRLVVVTSDGEAEARSRF--------------DDIVDVHVLDISSPGDADLDeeefagptrpaNAAFTLFTSGS 132
Cdd:PRK07769   123 AVLDDCTPSAILTTTDSAEGVRKFfrarpakerprviaVDAVPDEVGATWVPPEANED-----------TIAYLQYTSGS 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  133 TGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVREIFLPIAIGATLVIA-------EPGRHgdpvhLA 205
Cdd:PRK07769   192 TRIPAGVQITHLNLPTNVLQVIDALEGQEGDRGVSWLPFFHDMGLITVLLPALLGHYITFMspaafvrRPGRW-----IR 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  206 DLIRRHGVTVIHFVPAMLAAFNEVLGAGV---GE----LTSLRLIQTGGEALTPPVARDLM-----VRLPGTRLQNQYGP 273
Cdd:PRK07769   267 ELARKPGGTGGTFSAAPNFAFEHAAARGLpkdGEppldLSNVKGLLNGSEPVSPASMRKFNeafapYGLPPTAIKPSYGM 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  274 AEASIVVTIHRVTQDDRVI---------------PIGTPTR--RVS---------ARVLDA-ALREVPIGVPGELYLGGV 326
Cdd:PRK07769   347 AEATLFVSTTPMDEEPTVIyvdrdelnagrfvevPADAPNAvaQVSagkvgvsewAVIVDPeTASELPDGQIGEIWLHGN 426

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  327 QLARGYAGRPDLTAERF---VADPFGE-------PGARLYRTGDRARWnRDGEIEYLGRTDFQVKLRG-----QRLELGE 391
Cdd:PRK07769   427 NIGTGYWGKPEETAATFqniLKSRLSEshaegapDDALWVRTGDYGVY-FDGELYITGRVKDLVIIDGrnhypQDLEYTA 505

                          490
                   ....*....|....*...
gi 1827387616  392 VEAALAAAPGVLhAAAAV 409
Cdd:PRK07769   506 QEATKALRTGYV-AAFSV 522

PRK07445

O-succinylbenzoic acid--CoA ligase; Reviewed

1284-1532

3.04e-07

O-succinylbenzoic acid--CoA ligase; Reviewed

Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 55.77 E-value: 3.04e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1284 PSVLATVDPERAQYVRNLAT---GGEACPPELVERWSERGRRIFNCYGPTEatvwatrsrmTAGKPVTIgKPVDGFTVRV 1360
Cdd:PRK07445   215 PTQLQRLLQLRPQWLAQFRTillGGAPAWPSLLEQARQLQLRLAPTYGMTE----------TASQIATL-KPDDFLAGNN 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1361 LDGRL--H---EVPQGVVGELYLSTAGLARGYLgrpgqtavsfvadPFGEPGARMYATGDLVRVAKGGNLEFAGRADHQV 1435
Cdd:PRK07445   284 SSGQVlpHaqiTIPANQTGNITIQAQSLALGYY-------------PQILDSQGIFETDDLGYLDAQGYLHILGRNSQKI 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1436 KINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKhteVVAYLVakPGATIDSAAVLDEA-AQHLAAHMVPSQAIVI 1514
Cdd:PRK07445   351 ITGGENVYPAEVEAAILATGLVQDVCVLGLPDPHWGEV---VTAIYV--PKDPSISLEELKTAiKDQLSPFKQPKHWIPV 425

                          250
                   ....*....|....*...
gi 1827387616 1515 DEIPLTPAGKLDRAALPE 1532
Cdd:PRK07445   426 PQLPRNPQGKINRQQLQQ 443

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

1635-2069

3.60e-07

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 56.40 E-value: 3.60e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1635 PLPPVTSWMIEHSEEPADFADFSQSLVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTMNAGAGIVPAVREID 1714
Cdd:COG1020     23 AQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPVVAAPLPVVVLLVD 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1715 AEG-ALDPALVDAHRELLGAMDPGTGSLL-GTAVVNGEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELR 1792
Cdd:COG1020    103 LEAlAEAAAEAAAAAEALAPFDLLRGPLLrLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAELLRLYLAAYAGAPLPLP 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1793 PEATT--TRRIAHLLAGQVHARAREVDYWLEQLPERPTSFGTSADRPLHRRRDES--SLTYVVDDVAGSILTTVPQAFGS 1868
Cdd:COG1020    183 PLPIQyaDYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRgaRVSFRLPAELTAALRALARRHGV 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1869 SVDDVLLGALARAVRAWqldNGIADggpVTVSTEGHGRDESiagdegaiDLSRTVGWFTSITPLAVDAS-----SDVVHA 1943
Cdd:COG1020    263 TLFMVLLAAFALLLARY---SGQDD---VVVGTPVAGRPRP--------ELEGLVGFFVNTLPLRVDLSgdpsfAELLAR 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1944 VKSAKDARLSRPAggVGFGILR--YNSDGEIAHRPLPTIMYNYfgggtapstETAPDDFLpvsDRPNMPSSITGAMRSPS 2021
Cdd:COG1020    329 VRETLLAAYAHQD--LPFERLVeeLQPERDLSRNPLFQVMFVL---------QNAPADEL---ELPGLTLEPLELDSGTA 394

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 1827387616 2022 VFGINISTAGREERrLEAKVTYATDALDEAAASDIARRWHDELRAVVE 2069
Cdd:COG1020    395 KFDLTLTVVETGDG-LRLTLEYNTDLFDAATIERMAGHLVTLLEALAA 441

PRK09029

O-succinylbenzoic acid--CoA ligase; Provisional

2575-2742

4.16e-07

O-succinylbenzoic acid--CoA ligase; Provisional

Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 55.65 E-value: 4.16e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2575 ARRAPDHVAVVDGaGARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAER 2654
Cdd:PRK09029    13 AQVRPQAIALRLN-DEVLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQPL 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2655 VASMIEDSGAVLGlsvlasgdLPGQEFEWMRLDDDSVAAEIAAVPAGPItDAERlgevtaanLAYVIYTSGSTGRPKGVA 2734
Cdd:PRK09029    92 LEELLPSLTLDFA--------LVLEGENTFSALTSLHLQLVEGAHAVAW-QPQR--------LATMTLTSGSTGLPKAAV 154


                   ....*....
gi 1827387616 2735 VTHSG-LAN 2742
Cdd:PRK09029   155 HTAQAhLAS 163

PLN02387

long-chain-fatty-acid-CoA ligase family protein

2686-2996

6.76e-07

long-chain-fatty-acid-CoA ligase family protein

Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 55.12 E-value: 6.76e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2686 LDDDSVAAEIAAVPAG-----PITDAERLGEVT--------AANLAYVIYTSGSTGRPKGVAVTHSG-LANFARQESDRL 2751
Cdd:PLN02387   208 MDDEGVDSDSSLSGSSnwtvsSFSEVEKLGKENpvdpdlpsPNDIAVIMYTSGSTGLPKGVMMTHGNiVATVAGVMTVVP 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2752 NAGDNPVVLGFAsPSfdASVLEylLATvnEGTLAyrpseAVGGEVlerfiaEHGATHTFL---------TPSVLSTMDPT 2822
Cdd:PLN02387   288 KLGKNDVYLAYL-PL--AHILE--LAA--ESVMA-----AVGAAI------GYGSPLTLTdtsnkikkgTKGDASALKPT 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2823 ---AVPSL----------RVIAAGG--------------EAVPQPIVDRWAPATELHNL--------------------- 2854
Cdd:PLN02387   350 lmtAVPAIldrvrdgvrkKVDAKGGlakklfdiaykrrlAAIEGSWFGAWGLEKLLWDAlvfkkiravlggrirfmlsgg 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 ----------------------YGPTETTIGITIS-----SAMRPGDPVrlggPIGGVDLMVLDE---RLRPVPvgMP-G 2903
Cdd:PLN02387   430 aplsgdtqrfiniclgapigqgYGLTETCAGATFSewddtSVGRVGPPL----PCCYVKLVSWEEggyLISDKP--MPrG 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2904 ELYVAGGALSRGYLDRSGLTAERFTANPYGTagqRMYRTGDVVRWTPDTdtgglTLEYTGRSDDQVKLR-GLRIELGEIE 2982
Cdd:PLN02387   504 EIVIGGPSVTLGYFKNQEKTDEVYKVDERGM---RWFYTGDIGQFHPDG-----CLEIIDRKKDIVKLQhGEYVSLGKVE 575

                          410
                   ....*....|....
gi 1827387616 2983 AVLAEHDAVESAVV 2996
Cdd:PLN02387   576 AALSVSPYVDNIMV 589

PRK08308

acyl-CoA synthetase; Validated

128-474

7.01e-07

acyl-CoA synthetase; Validated

Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 54.66 E-value: 7.01e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  128 FTSGSTGRPKAVVITHRGIANRLAADIEQYDLTARDVFLYKAPITFDVSVreiflpiaIGATLVIAEPGR------HGDP 201
Cdd:PRK08308   108 YSSGTTGEPKLIRRSWTEIDREIEAYNEALNCEQDETPIVACPVTHSYGL--------ICGVLAALTRGSkpviitNKNP 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  202 VHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVgeltSLRLIQTGGEALTPPVARDLMVRlpGTRLQNQYGPAEASIVVT 281
Cdd:PRK08308   180 KFALNILRNTPQHILYAVPLMLHILGRLLPGTF----QFHAVMTSGTPLPEAWFYKLRER--TTYMMQQYGCSEAGCVSI 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  282 IHRVTQDDRvipIGTPTRRVSarvLDAALREvpiGVPGELYLggvqlargyagrpdltaerfvadpfgEPGARLYRTGDR 361
Cdd:PRK08308   254 CPDMKSHLD---LGNPLPHVS---VSAGSDE---NAPEEIVV--------------------------KMGDKEIFTKDL 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  362 ARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGYLAPADVDVDTVAATT--AEL 439
Cdd:PRK08308   299 GYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKAKVISHEEIDPVQLREwcIQH 378

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1827387616  440 LPEYMRPSAWVRLDAMPLSRSGKVDRRLLPEPEIA 474
Cdd:PRK08308   379 LAPYQVPHEIESVTEIPKNANGKVSRKLLELGEVT 413

PaaK

COG1541

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...

129-416

7.30e-07

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];

Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 54.38 E-value: 7.30e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  129 TSGSTGRPKAVVITHRGI---ANRLAADIEQYDLTARDVF-------LYKAPITFDVSVReiflpiAIGATLViaePGRH 198
Cdd:COG1541     91 SSGTTGKPTVVGYTRKDLdrwAELFARSLRAAGVRPGDRVqnafgygLFTGGLGLHYGAE------RLGATVI---PAGG 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  199 GDPVHLADLIRRHGVTVIHFVPAMLAAFNEVL---GAGVGELtSLRLIQTGGEALTPPVaRDLMVRLPGTRLQNQYGPAE 275
Cdd:COG1541    162 GNTERQLRLMQDFGPTVLVGTPSYLLYLAEVAeeeGIDPRDL-SLKKGIFGGEPWSEEM-RKEIEERWGIKAYDIYGLTE 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  276 ASIVVTI--------HrVTQDDRVIPIGTP-TRRVsarvldaalreVPIGVPGELYLGGvqlargyagrpdLTAE----- 341
Cdd:COG1541    240 VGPGVAYeceaqdglH-IWEDHFLVEIIDPeTGEP-----------VPEGEEGELVVTT------------LTKEampli 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  342 RfvadpfgepgarlYRTGDRARWNRDGE--------IEY-LGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDG 412
Cdd:COG1541    296 R-------------YRTGDLTRLLPEPCpcgrthprIGRiLGRADDMLIIRGVNVFPSQIEEVLLRIPEVGPEYQIVVDR 362


                   ....
gi 1827387616  413 PGGQ 416
Cdd:COG1541    363 EGGL 366

CT_NRPS-like

cd19542

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

1661-2059

7.82e-07

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 54.23 E-value: 7.82e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1661 VFNVPASAAVADLQTVVEAVAAAHPML-TAVLTRSGDGWTMnagaGIV-----PAVREI-DAEGALDPALVDAHRELLGA 1733
Cdd:cd19542     27 VFDLDSSVDVERLRNAWRQLVQRHDILrTVFVESSAEGTFL----QVVlksldPPIEEVeTDEDSLDALTRDLLDDPTLF 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1734 MDPGTgSLlgTAVVNGEGRRRLVIAIHHLGVDAVSWPILVEDLvtawAQLTSGRPIelrPEATTTRRIAHLLAGQVHARA 1813
Cdd:cd19542    103 GQPPH-RL--TLLETSSGEVYLVLRISHALYDGVSLPIILRDL----AAAYNGQLL---PPAPPFSDYISYLQSQSQEES 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1814 RevDYWLEQL-PERPTSFGTSADRPLHRRRDESSltyvvdDVAGSILTTVPQAFGSSVDDVLLGALARAVRAW-QLDNgi 1891
Cdd:cd19542    173 L--QYWRKYLqGASPCAFPSLSPKRPAERSLSST------RRSLAKLEAFCASLGVTLASLFQAAWALVLARYtGSRD-- 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1892 adggpVTVSTEGHGRDESIAGdegaIDlsRTVGWFTSITPLAVD-----ASSDVVHAVKSAKDArlSRPAGGVGFG-ILR 1965
Cdd:cd19542    243 -----VVFGYVVSGRDLPVPG----ID--DIVGPCINTLPVRVKldpdwTVLDLLRQLQQQYLR--SLPHQHLSLReIQR 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1966 ynSDGEIAHRPLPTIMYNYFGGGTAPSTETAPDDFLpvsdrpnmpSSITGAMRSPSVFGINISTAGREerrLEAKVTYAT 2045
Cdd:cd19542    310 --ALGLWPSGTLFNTLVSYQNFEASPESELSGSSVF---------ELSAAEDPTEYPVAVEVEPSGDS---LKVSLAYST 375

                          410
                   ....*....|....
gi 1827387616 2046 DALDEAAASDIARR 2059
Cdd:cd19542    376 SVLSEEQAEELLEQ 389

AFD_CAR-like

cd17632

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ...

26-402

8.56e-07

Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 54.77 E-value: 8.56e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   26 VAVGIQIDRSVEQVVAIhaVAMAGGHFVPLD-EQLPVDRARYMVRTAGVRLVV--------VTSDGEAEARSRFDDI--- 93
Cdd:cd17632    119 VSVPLQAGASAAQLAPI--LAETEPRLLAVSaEHLDLAVEAVLEGGTPPRLVVfdhrpevdAHRAALESARERLAAVgip 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   94 VDVHVLDISSPGDADLDEEEFAGPTRPANAAFtLFTSGSTGRPKAVVITHRGIANR-LAADIEQYDLTARDVFLYKAPIT 172
Cdd:cd17632    197 VTTLTLIAVRGRDLPPAPLFRPEPDDDPLALL-IYTSGSTGTPKGAMYTERLVATFwLKVSSIQDIRPPASITLNFMPMS 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  173 FDVSVREIFLPIAIGAT---------------LVIAEPGRHGDPVHLADLI-RRHGVTVIHFVPAmlAAFNEVLGAGVGe 236
Cdd:cd17632    276 HIAGRISLYGTLARGGTayfaaasdmstlfddLALVRPTELFLVPRVCDMLfQRYQAELDRRSVA--GADAETLAERVK- 352

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  237 lTSLRLIQTGGEALT-----PPVARDL---MVRLPGTRLQNQYGPAEASIVVTihrvtqDDRVipigtptrrVSARVLDA 308
Cdd:cd17632    353 -AELRERVLGGRLLAavcgsAPLSAEMkafMESLLDLDLHDGYGSTEAGAVIL------DGVI---------VRPPVLDY 416

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  309 ALREVP-IGV--------PGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGD-RARWNRDgEIEYLGRTDF 378
Cdd:cd17632    417 KLVDVPeLGYfrtdrphpRGELLVKTDTLFPGYYKRPEVTAEVFDEDGF-------YRTGDvMAELGPD-RLVYVDRRNN 488

                          410       420
                   ....*....|....*....|....*
gi 1827387616  379 QVKL-RGQRLELGEVEAALAAAPGV 402
Cdd:cd17632    489 VLKLsQGEFVTVARLEAVFAASPLV 513

PLN03051

acyl-activating enzyme; Provisional

2720-3028

8.96e-07

acyl-activating enzyme; Provisional

Pssm-ID: 215552 [Multi-domain] Cd Length: 499 Bit Score: 54.44 E-value: 8.96e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2720 VIYTSGSTGRPKGVAVTHS--------GLANFARQESDRLNAgdnPVVLGFASpsfdASVLEYlLATVNEGTLAYRPSEA 2791
Cdd:PLN03051   124 ILFSSGTTGEPKAIPWTHLsplrcasdGWAHMDIQPGDVVCW---PTNLGWMM----GPWLLY-SAFLNGATLALYGGAP 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2792 VGGEVLErFIAEHGATHTFLTPSVLST--------MDPTAVPSLRVIAAGGEAvPQPIVDRW--------APATElhnLY 2855
Cdd:PLN03051   196 LGRGFGK-FVQDAGVTVLGLVPSIVKAwrhtgafaMEGLDWSKLRVFASTGEA-SAVDDVLWlssvrgyyKPVIE---YC 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2856 GPTETTIGITISSAMRPGDPVRLGGPIGGVDLMVLDERLRPVPVGMPGELYVAGGALSRGYLDRSgLTAER----FTANP 2931
Cdd:PLN03051   271 GGTELASGYISSTLLQPQAPGAFSTASLGTRFVLLNDNGVPYPDDQPCVGEVALAPPMLGASDRL-LNADHdkvyYKGMP 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2932 -YGTAGQRMYRTGDVVRWTPdtdtgGLTLEYTGRSDDQVKLRGLRIELGEIEAVLAEHDAvesavvlgvggSVATALAAY 3010
Cdd:PLN03051   350 mYGSKGMPLRRHGDIMKRTP-----GGYFCVQGRADDTMNLGGIKTSSVEIERACDRAVA-----------GIAETAAVG 413

                          330
                   ....*....|....*...
gi 1827387616 3011 IVPVDGAVEVSELKAFAG 3028
Cdd:PLN03051   414 VAPPDGGPELLVIFLVLG 431

AMP-binding_C

pfam13193

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...

391-462

9.42e-07

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.

Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 48.69 E-value: 9.42e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616  391 EVEAALAAAPGVLHAAA-AVVDGPGGQQLVGYLAP---ADVDVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGK 462
Cdd:pfam13193    1 EVESALVSHPAVAEAAVvGVPDELKGEAPVAFVVLkpgVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76

DCL_NRPS-like

cd19536

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

1749-2057

1.48e-06

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 53.61 E-value: 1.48e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1749 GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAWAQLTSGRPIELRPEATTTRRIAHLLAgqVHARAREVDYWLEQLPE--- 1825
Cdd:cd19536    123 ERERFLLVISDHHSILDGWSLYLLVKEILAVYNQLLEYKPLSLPPAQPYRDFVAHERA--SIQQAASERYWREYLAGatl 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1826 RPTSFGTSADRPLHRRRDEssltYVVDDVAGSILTTVPQAFGSSVDDVLLGALARAVRAWQldngiaDGGPVTVSTEGHG 1905
Cdd:cd19536    201 ATLPALSEAVGGGPEQDSE----LLVSVPLPVRSRSLAKRSGIPLSTLLLAAWALVLSRHS------GSDDVVFGTVVHG 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1906 RDESIAGDEgaidlsRTVGWFTSITPLAVDAS----SDVVHAVKSAKDARLSRPAGGVgfGILRYNSDGEiahrPLPTIM 1981
Cdd:cd19536    271 RSEETTGAE------RLLGLFLNTLPLRVTLSeetvEDLLKRAQEQELESLSHEQVPL--ADIQRCSEGE----PLFDSI 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1982 YNY------FGGGTAPSTETAPDDFLPVSDRPNMPssitgamrspsvfgINISTAGREErRLEAKVTYATDALDEAAASD 2055
Cdd:cd19536    339 VNFrhfdldFGLPEWGSDEGMRRGLLFSEFKSNYD--------------VNLSVLPKQD-RLELKLAYNSQVLDEEQAQR 403


                   ..
gi 1827387616 2056 IA 2057
Cdd:cd19536    404 LA 405

PKS_PP

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...

486-554

2.18e-06

Pssm-ID: 214834 [Multi-domain] Cd Length: 86 Bit Score: 48.02 E-value: 2.18e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616   486 EETVAGLFAELLGV---ERVGVTDSFFDIGGSSLSAARIAARVSKELGVDVSVRDVFESPSVRGLVHAVSGR 554
Cdd:smart00823   14 LDLVREQVAAVLGHaaaEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAAE 85

PRK06334

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

1183-1451

2.19e-06

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 53.28 E-value: 2.19e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1183 NLAYLIYTSGSTGRPKAVGVSHTGIVDfvNSLAKITTGTPEdEPDTRILHVasPSFDASMFEMAWAIP--AGHTLVIA-- 1258
Cdd:PRK06334   184 DVAVILFTSGTEKLPKGVPLTHANLLA--NQRACLKFFSPK-EDDVMMSFL--PPFHAYGFNSCTLFPllSGVPVVFAyn 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1259 ---PQ--ADFAGDALATVLERDEV-TDMIITPsvlATVDPERAQYVRNLATGGEACPPELVERWSERGRRI--FNCYGPT 1330
Cdd:PRK06334   259 plyPKkiVEMIDEAKVTFLGSTPVfFDYILKT---AKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIqlRQGYGTT 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1331 EAT-VWATRSRMTAGKPVTIGKPVDGFTVRVLDGRLH-EVPQGVVGELYLSTAGLARGYLGR-PGQTAVSFvadpfgePG 1407
Cdd:PRK06334   336 ECSpVITINTVNSPKHESCVGMPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYLGEdFGQGFVEL-------GG 408

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1827387616 1408 ARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVL 1451
Cdd:PRK06334   409 ETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEALESIL 452

PRK07445

O-succinylbenzoic acid--CoA ligase; Reviewed

2903-3061

2.98e-06

O-succinylbenzoic acid--CoA ligase; Reviewed

Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 52.69 E-value: 2.98e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2903 GELYVAGGALSRGYLdrsgltaerftanPYGTAGQRMYRTGDVVRWtpdtDTGGlTLEYTGRSDDQVKLRGLRIELGEIE 2982
Cdd:PRK07445   302 GNITIQAQSLALGYY-------------PQILDSQGIFETDDLGYL----DAQG-YLHILGRNSQKIITGGENVYPAEVE 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2983 AVLAEHDAVESAVVLGVG----GSVATALAayiVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRA 3058
Cdd:PRK07445   364 AAILATGLVQDVCVLGLPdphwGEVVTAIY---VPKDPSISLEELKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQ 440


                   ...
gi 1827387616 3059 LPE 3061
Cdd:PRK07445   441 LQQ 443

PLN02246

4-coumarate--CoA ligase

2577-3059

3.13e-06

4-coumarate--CoA ligase

Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 52.68 E-value: 3.13e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2577 RAPDHVAVVDGA-GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGGAYVPIDPDYPAERV 2655
Cdd:PLN02246    35 EFSDRPCLIDGAtGRVYTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTANPFYTPAEI 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2656 ASMIEDSGAVL------------------GLSVLASGDLPGQ--EFEWMRLDDDSVAAEIAAVPAGPITdaerlgevtaa 2715
Cdd:PLN02246   115 AKQAKASGAKLiitqscyvdklkglaeddGVTVVTIDDPPEGclHFSELTQADENELPEVEISPDDVVA----------- 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2716 nlayVIYTSGSTGRPKGVAVTHSGLANFARQESDrlnaGDNP--------VVLGFAsPSFDASVLE-YLLATVNEG-TLA 2785
Cdd:PLN02246   184 ----LPYSSGTTGLPKGVMLTHKGLVTSVAQQVD----GENPnlyfhsddVILCVL-PMFHIYSLNsVLLCGLRVGaAIL 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2786 YRPSEAVgGEVLErFIAEHGAT-HTFLTPSVLS-----TMDPTAVPSLRVIAAGgeAVP-----QPIVDRWAPATELHNL 2854
Cdd:PLN02246   255 IMPKFEI-GALLE-LIQRHKVTiAPFVPPIVLAiakspVVEKYDLSSIRMVLSG--AAPlgkelEDAFRAKLPNAVLGQG 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2855 YGPTE--TTIGITISSAMRPGdPVRlGGPIGGV----DLMVLD-ERLRPVPVGMPGELYVAGGALSRGYLDrsgltaerf 2927
Cdd:PLN02246   331 YGMTEagPVLAMCLAFAKEPF-PVK-SGSCGTVvrnaELKIVDpETGASLPRNQPGEICIRGPQIMKGYLN--------- 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2928 taNPYGTAgqrmyRTGDVVRWTPDTDTGgltleYTGRSD-----DQV----KLRGLRIELGEIEAVLAEHDAVESAVVLG 2998
Cdd:PLN02246   400 --DPEATA-----NTIDKDGWLHTGDIG-----YIDDDDelfivDRLkeliKYKGFQVAPAELEALLISHPSIADAAVVP 467

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827387616 2999 VGGSVATAL-AAYIVPVDGAvEVSE--LKAFAGGRLPAYMVPSSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PLN02246   468 MKDEVAGEVpVAFVVRSNGS-EITEdeIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDL 530

FATP_chFAT1_like

cd05937

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...

312-446

3.83e-06

Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 52.43 E-value: 3.83e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  312 EVPIGVPGE----LYLGGVQLARGYAGRPDLTAERFVADPFgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRL 387
Cdd:cd05937    293 RAPVGEPGEmlgrVPFKNREAFQGYLHNEDATESKLVRDVF-RKGDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENV 371

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827387616  388 ELGEVEAALAAAPGVLHAAAAVVDGPGGQQLVGYLA---------PADVDVDTVAATTAELLPEYMRP 446
Cdd:cd05937    372 STTEVADVLGAHPDIAEANVYGVKVPGHDGRAGCAAitleessavPTEFTKSLLASLARKNLPSYAVP 439

PLN02654

acetate-CoA ligase

125-468

3.95e-06

acetate-CoA ligase

Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 52.59 E-value: 3.95e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  125 FTLFTSGSTGRPKAVVITHRGIANRLAADIEQ-YDLTARDVFLYKAP---ITFDVSVreIFLPIAIGATLVIAEPG-RHG 199
Cdd:PLN02654   279 FLLYTSGSTGKPKGVLHTTGGYMVYTATTFKYaFDYKPTDVYWCTADcgwITGHSYV--TYGPMLNGATVLVFEGApNYP 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  200 DPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELT--SLRLIQTGGEALTPPVAR-------DLMVRLPGTRLQNQ 270
Cdd:PLN02654   357 DSGRCWDIVDKYKVTIFYTAPTLVRSLMRDGDEYVTRHSrkSLRVLGSVGEPINPSAWRwffnvvgDSRCPISDTWWQTE 436

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  271 YGpaeaSIVVTihrvtqddrVIPIGTPTRRVSAR-----VLDAALREVPIGVPGEL--YL-------GGVQLARGYAGRP 336
Cdd:PLN02654   437 TG----GFMIT---------PLPGAWPQKPGSATfpffgVQPVIVDEKGKEIEGECsgYLcvkkswpGAFRTLYGDHERY 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  337 DLTaerfvadpFGEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVVDGP-GG 415
Cdd:PLN02654   504 ETT--------YFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQCAEAAVVGIEHEvKG 575

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827387616  416 QQLVGYLA-----PADVDV-DTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLL 468
Cdd:PLN02654   576 QGIYAFVTlvegvPYSEELrKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRIL 634

PRK05850

acyl-CoA synthetase; Validated

8-360

3.99e-06

acyl-CoA synthetase; Validated

Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 52.64 E-value: 3.99e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    8 RRVTGLARELTALGVGAEVAVgIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPV---DRARYMVRTAGVRLVVVTSDGEA 84
Cdd:PRK05850    43 RRTLNVAEELRRHGSTGDRAV-ILAPQGLEYIVAFLGALQAGLIAVPLSVPQGGahdERVSAVLRDTSPSVVLTTSAVVD 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   85 EARSRFDD--------IVDVHVLDISSPGDADLDEEEfagptrPANAAFTLFTSGSTGRPKAVVITHRGianrLAADIEQ 156
Cdd:PRK05850   122 DVTEYVAPqpgqsappVIEVDLLDLDSPRGSDARPRD------LPSTAYLQYTSGSTRTPAGVMVSHRN----VIANFEQ 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  157 ydlTARDVFLYKA----PITFDVS----------VREIFLPIAIGATLVIAEPgrhgdpvhLADLIRrhgvtvihfvPA- 221
Cdd:PRK05850   192 ---LMSDYFGDTGgvppPDTTVVSwlpfyhdmglVLGVCAPILGGCPAVLTSP--------VAFLQR----------PAr 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  222 ---MLA------------AFNEVLG-------AGVgELTSLRLIQTGGEALTPPVARDLMVR-----LPGTRLQNQYGPA 274
Cdd:PRK05850   251 wmqLLAsnphafsaapnfAFELAVRktsdddmAGL-DLGGVLGIISGSERVHPATLKRFADRfapfnLRETAIRPSYGLA 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  275 EASIVVTIHRVTQDDRVI---------------PIGTPTRRVS--------ARVLDA-ALREVPIGVPGELYLGGVQLAR 330
Cdd:PRK05850   330 EATVYVATREPGQPPESVrfdyeklsaghakrcETGGGTPLVSygsprsptVRIVDPdTCIECPAGTVGEIWVHGDNVAA 409

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1827387616  331 GYAGRPDLTAERF---VADPF-GEPGARLYRTGD 360
Cdd:PRK05850   410 GYWQKPEETERTFgatLVDPSpGTPEGPWLRTGD 443

LC_FACS_bac

cd05932

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...

13-375

4.80e-06

Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 52.09 E-value: 4.80e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   13 LARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGGHFVPLDEQLPVDRARYMVRTAGVRLVVV--TSDGEAEARSRF 90
Cdd:cd05932     19 LAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALFVgkLDDWKAMAPGVP 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   91 DDIVDVhvldISSPGDADLDEEEF------------AGPTRPANAAFTLFTSGSTGRPKAVVITHRGIANRLAADIEQYD 158
Cdd:cd05932     99 EGLISI----SLPPPSAANCQYQWddliaqhppleeRPTRFPEQLATLIYTSGTTGQPKGVMLTFGSFAWAAQAGIEHIG 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  159 LTARDVFLYKAPITFDVSVREIFLPIAIGATLV-IAEpgrhGDPVHLADLiRRHGVTVIHFVPAMLAAFNE--------- 228
Cdd:cd05932    175 TEENDRMLSYLPLAHVTERVFVEGGSLYGGVLVaFAE----SLDTFVEDV-QRARPTLFFSVPRLWTKFQQgvqdkipqq 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  229 ---------VLGAGVGE--LTSLRLIQT----GGEALTPPVARDLMVRLpGTRLQNQYGPAEASIVVTIHRvTQDDRVIP 293
Cdd:cd05932    250 klnlllkipVVNSLVKRkvLKGLGLDQCrlagCGSAPVPPALLEWYRSL-GLNILEAYGMTENFAYSHLNY-PGRDKIGT 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  294 IGTPTRRVsarvldaalrEVPIGVPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYL 373
Cdd:cd05932    328 VGNAGPGV----------EVRISEDGEILVRSPALMMGYYKDPEATAEAFTADGF-------LRTGDKGELDADGNLTIT 390


                   ..
gi 1827387616  374 GR 375
Cdd:cd05932    391 GR 392

PaaK

cd05913

Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic ...

2723-2993

9.12e-06

Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.

Pssm-ID: 341239 [Multi-domain] Cd Length: 425 Bit Score: 51.09 E-value: 9.12e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2723 TSGSTGRPKGVAVTHSGLANFARQES-------------------DRLNAGDNPVVLGfaspsfdasvLEYLLATVnegt 2783
Cdd:cd05913     86 SSGTTGKPTVVGYTKNDLDVWAELVArcldaagvtpgdrvqnaygYGLFTGGLGFHYG----------AERLGALV---- 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2784 layrpsEAVGGEVLER---FIAEHGATHTFLTPSVLSTM---------DPTAVpSLRVIAAGGEAVPQP----IVDRWAp 2847
Cdd:cd05913    152 ------IPAGGGNTERqlqLIKDFGPTVLCCTPSYALYLaeeaeeegiDPREL-SLKVGIFGAEPWTEEmrkrIERRLG- 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2848 aTELHNLYGPTETT-IGITISSAMRPGdpvrlggpIGGVDLMVL-----DERLRPVPVGMPGELYVAGgalsrgyLDRSG 2921
Cdd:cd05913    224 -IKAYDIYGLTEIIgPGVAFECEEKDG--------LHIWEDHFIpeiidPETGEPVPPGEVGELVFTT-------LTKEA 287

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827387616 2922 LTAERftanpygtagqrmYRTGDVVRWTPDTDTGGLTL----EYTGRSDDQVKLRGLRIELGEIEAVLAEHDAVES 2993
Cdd:cd05913    288 MPLIR-------------YRTRDITRLLPGPCPCGRTHrridRITGRSDDMLIIRGVNVFPSQIEDVLLKIPGLGP 350

PRK09294

phthiocerol/phthiodiolone dimycocerosyl transferase;

2134-2412

9.32e-06

phthiocerol/phthiodiolone dimycocerosyl transferase;

Pssm-ID: 181765 [Multi-domain] Cd Length: 416 Bit Score: 50.86 E-value: 9.32e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2134 VYVTQTVLsLTGDVDPGRLRSALSELLARQRVLRSGFVRLPSGAAvTVVPAEVTVPWsvidlraedAASLDSRVEEVLAT 2213
Cdd:PRK09294    22 AFTGYTAH-LRGVLDIDALSDAFDALLRAHPVLAAHLEQDSDGGW-ELVADDLLHPG---------IVVVDGDAARPLPE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2214 ERTNPFDMakppLIRVVLVEHGDGAELVVTNHHLLIDGWSSPLVLADLLSLYATGQTfTGSLPGT-------SGRDFADH 2286
Cdd:PRK09294    91 LQLDQGVS----LLALDVVPDDGGARVTLYIHHSIADAHHSASLLDELWSRYTDVVT-TGDPGPIrpqpapqSLEAVLAQ 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2287 --ARAVATADVEAGIAAWREVLAPVTEPTlvAPGHEPSADAPPRDHQFSIDVKVTERLEALARNNSTTMATVVQFAWAMF 2364
Cdd:PRK09294   166 rgIRRQALSGAERFMPAMYAYELPPTPTA--AVLAKPGLPQAVPVTRCRLSKAQTSSLAAFGRRHRLTVNALVSAAILLA 243

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1827387616 2365 LSRLTGTRTVT--FAETVSGR---SPDIEGMESMVGMFINTIPAVVDVNPDAT 2412
Cdd:PRK09294   244 EWQLRRTPHVPlpYVYPVDLRfrlTPPVAATEGTNLLGAATYLAEIGPDTDIV 296

PRK07445

O-succinylbenzoic acid--CoA ligase; Reviewed

353-470

3.10e-05

O-succinylbenzoic acid--CoA ligase; Reviewed

Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 49.61 E-value: 3.10e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  353 ARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVlhAAAAVV---DGPGGQQLVGYLAPAD--V 427
Cdd:PRK07445   323 QGIFETDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLV--QDVCVLglpDPHWGEVVTAIYVPKDpsI 400

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1827387616  428 DVDTVAATTAELLPEYMRPSAWVRLDAMPLSRSGKVDRRLLPE 470
Cdd:PRK07445   401 SLEELKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQLQQ 443

PRK05850

acyl-CoA synthetase; Validated

2566-2743

3.92e-05

acyl-CoA synthetase; Validated

Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 49.17 E-value: 3.92e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2566 TLAELFRAAARRAPDHVAVV--------DGAGARLTYRELDEASDRLARWLIGRGVGPERAVALAiGRSAQLLTAIWAVA 2637
Cdd:PRK05850     2 SVPSLLRERASLQPDDAAFTfidyeqdpAGVAETLTWSQLYRRTLNVAEELRRHGSTGDRAVILA-PQGLEYIVAFLGAL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2638 KTGGAYVPIDPDYPA---ERVASMIEDSGAVLglsVLASGDLPGQEFEWMRLDDDSVAAEIAAV-------PAGPitdae 2707
Cdd:PRK05850    81 QAGLIAVPLSVPQGGahdERVSAVLRDTSPSV---VLTTSAVVDDVTEYVAPQPGQSAPPVIEVdlldldsPRGS----- 152

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1827387616 2708 RLGEVTAANLAYVIYTSGSTGRPKGVAVTHSGL-ANF 2743
Cdd:PRK05850   153 DARPRDLPSTAYLQYTSGSTRTPAGVMVSHRNViANF 189

PRK03584

acetoacetate--CoA ligase;

96-252

4.12e-05

acetoacetate--CoA ligase;

Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 49.41 E-value: 4.12e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   96 VHVLDISSPGDADLDEEEFAGPTRPANAAFT----------LFTSGSTGRPKAVVITHRGI------ANRLaadieQYDL 159
Cdd:PRK03584   228 LGPAAAAAALPGALLWEDFLAPAEAAELEFEpvpfdhplwiLYSSGTTGLPKCIVHGHGGIllehlkELGL-----HCDL 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  160 TARDVFLYkapIT--------FDVSVreiflpIAIGATLVIAE--PGrHGDPVHLADLIRRHGVTVIHFVPAMLAAfneV 229
Cdd:PRK03584   303 GPGDRFFW---YTtcgwmmwnWLVSG------LLVGATLVLYDgsPF-YPDPNVLWDLAAEEGVTVFGTSAKYLDA---C 369

                          170       180
                   ....*....|....*....|....*...
gi 1827387616  230 LGAGV-----GELTSLRLIQTGGEALTP 252
Cdd:PRK03584   370 EKAGLvpgetHDLSALRTIGSTGSPLPP 397

PRK05857

fatty acid--CoA ligase;

2564-2860

4.85e-05

fatty acid--CoA ligase;

Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 48.85 E-value: 4.85e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2564 PVTLAELFRAAARRAPDHVAV--VDGAGArLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLTAIWAVAKTGG 2641
Cdd:PRK05857    13 PSTVLDRVFEQARQQPEAIALrrCDGTSA-LRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2642 AYVPIDPDYPAERVA--SMIEDSGAVLglsvLASGDlpgqefewmRLDDDSVAAEIAAVPAGPITDAERLGEVT------ 2713
Cdd:PRK05857    92 IAVMADGNLPIAAIErfCQITDPAAAL----VAPGS---------KMASSAVPEALHSIPVIAVDIAAVTRESEhsldaa 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2714 --AANLAY-------VIYTSGSTGRPKGVAV---THSGLANFARQESdrLNAGDNPVVLGFASPSFDASV--LEYLLATV 2779
Cdd:PRK05857   159 slAGNADQgsedplaMIFTSGTTGEPKAVLLanrTFFAVPDILQKEG--LNWVTWVVGETTYSPLPATHIggLWWILTCL 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2780 NEGTLAYRPSEAvGGEVLERFIAEHGAThTFLTPSVLSTM------DPTAVPSLRVIAAGGEAVPQPIVdRWAPATELH- 2852
Cdd:PRK05857   237 MHGGLCVTGGEN-TTSLLEILTTNAVAT-TCLVPTLLSKLvselksANATVPSLRLVGYGGSRAIAADV-RFIEATGVRt 313


                   ....*....
gi 1827387616 2853 -NLYGPTET 2860
Cdd:PRK05857   314 aQVYGLSET 322

AACS

cd05943

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...

2-252

5.10e-05

Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 49.19 E-value: 5.10e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616    2 SRAEFDRRVTGLARELTALGVGAEVAVGIQIDRSVEQVVAIHAVAMAGG----------------HFVPLDEQL--PVDR 63
Cdd:cd05943    100 TWAELRRRVARLAAALRALGVKPGDRVAGYLPNIPEAVVAMLATASIGAiwsscspdfgvpgvldRFGQIEPKVlfAVDA 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616   64 ARYMVRTAGVRLVVvtsdgeAEARSRFDDIVD-VHVLDISSPGDADLDE-------EEFAGPTRPANAAFT--------- 126
Cdd:cd05943    180 YTYNGKRHDVREKV------AELVKGLPSLLAvVVVPYTVAAGQPDLSKiakaltlEDFLATGAAGELEFEplpfdhply 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  127 -LFTSGSTGRPKAVVITHRGI-ANRLAADIEQYDLTARDVFLYKAPIT-----FDVSvreiflPIAIGATLVI--AEPGr 197
Cdd:cd05943    254 iLYSSGTTGLPKCIVHGAGGTlLQHLKEHILHCDLRPGDRLFYYTTCGwmmwnWLVS------GLAVGATIVLydGSPF- 326

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827387616  198 HGDPVHLADLIRRHGVTVIHFVPAMLAAFNE--VLGAGVGELTSLRLIQTGGEALTP 252
Cdd:cd05943    327 YPDTNALWDLADEEGITVFGTSAKYLDALEKagLKPAETHDLSSLRTILSTGSPLKP 383

Cyc_NRPS

cd19535

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

1673-1827

7.91e-05

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 47.87 E-value: 7.91e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1673 LQTVVEAVAAAHPMLTAVLTRSGDGWTMNAGAgiVPAVREIDAEGaLDPALVDAH----RELLGA--MDPGTGSLLGTAV 1746
Cdd:cd19535     42 LERAWNKLIARHPMLRAVFLDDGTQQILPEVP--WYGITVHDLRG-LSEEEAEAAleelRERLSHrvLDVERGPLFDIRL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1747 VN-GEGRRRLVIAIHHLGVDAVSWPILVEDlvtaWAQLTSGRPIELRPEATTTRR-IAHLLAGQVHARAREVDYWLEQLP 1824
Cdd:cd19535    119 SLlPEGRTRLHLSIDLLVADALSLQILLRE----LAALYEDPGEPLPPLELSFRDyLLAEQALRETAYERARAYWQERLP 194


                   ...
gi 1827387616 1825 ERP 1827
Cdd:cd19535    195 TLP 197

DCL_NRPS

cd19543

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

1634-2069

1.11e-04

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 47.58 E-value: 1.11e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1634 MPLPPVTSWMIEHS-EEPADFADFSQSlVFNVPASAAVADLQTVVEAVAAAHPMLTAVLTRSGDGWTMNagagIVPA--- 1709
Cdd:cd19543      2 YPLSPMQEGMLFHSlLDPGSGAYVEQM-VITLEGPLDPDRFRAAWQAVVDRHPILRTSFVWEGLGEPLQ----VVLKdrk 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1710 --VREIDAEGaLDPALVDAH-RELLGA-----MDPGTGSLLGTAVVN-GEGRRRLVIAIHHLGVDAVSWPILVEDLVTAW 1780
Cdd:cd19543     77 lpWRELDLSH-LSEAEQEAElEALAEEdrergFDLARAPLMRLTLIRlGDDRYRLVWSFHHILLDGWSLPILLKELFAIY 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1781 AQLTSGRPIELRPEATTTRRIAhLLAGQVHARARevDYWLEQLP--ERPTSFGTSADRPLHRRRDESSLTYVVDDVAGSI 1858
Cdd:cd19543    156 AALGEGQPPSLPPVRPYRDYIA-WLQRQDKEAAE--AYWREYLAgfEEPTPLPKELPADADGSYEPGEVSFELSAELTAR 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1859 LTTVPQAFGSSVDDVLLGA----LARAvrawqldNGIAD---GgpVTVSteghGRDESIAGDEgaidlsRTVGWFTSITP 1931
Cdd:cd19543    233 LQELARQHGVTLNTVVQGAwallLSRY-------SGRDDvvfG--TTVS----GRPAELPGIE------TMVGLFINTLP 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1932 LAVDASSD--VVHAVKSAKDARL-SRPAGGVGFGILRYNSDGeiaHRPL-PTIMY--NYfgggtapstetaPDDFLPVSD 2005
Cdd:cd19543    294 VRVRLDPDqtVLELLKDLQAQQLeLREHEYVPLYEIQAWSEG---KQALfDHLLVfeNY------------PVDESLEEE 358

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827387616 2006 RPNMPSSITG-AMRSPSVFGINISTAGREErrLEAKVTYATDALDEAAASDIARRWHDELRAVVE 2069
Cdd:cd19543    359 QDEDGLRITDvSAEEQTNYPLTVVAIPGEE--LTIKLSYDAEVFDEATIERLLGHLRRVLEQVAA 421

PLN02654

acetate-CoA ligase

1186-1466

1.28e-04

acetate-CoA ligase

Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 47.58 E-value: 1.28e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1186 YLIYTSGSTGRPKavGVSHTgivdfvnslakitTGTPEDEPDTRILHvaspSFDASMFEMAWAIP-----AGHTLVI--- 1257
Cdd:PLN02654   279 FLLYTSGSTGKPK--GVLHT-------------TGGYMVYTATTFKY----AFDYKPTDVYWCTAdcgwiTGHSYVTygp 339

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1258 ------------APQADFAGDALATVlERDEVTDMIITPSVLATVDPERAQYV--------RNLATGGEACPPElVERWs 1317
Cdd:PLN02654   340 mlngatvlvfegAPNYPDSGRCWDIV-DKYKVTIFYTAPTLVRSLMRDGDEYVtrhsrkslRVLGSVGEPINPS-AWRW- 416

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1318 ergrrIFNCYG----PTEATVWATRsrmTAG------------KPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYL--S 1379
Cdd:PLN02654   417 -----FFNVVGdsrcPISDTWWQTE---TGGfmitplpgawpqKPGSATFPFFGVQPVIVDEKGKEIEGECSGYLCVkkS 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1380 TAGLARGYLGRPGQTAVSFVAdPFgepgARMYATGDLVRVAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQ 1459
Cdd:PLN02654   489 WPGAFRTLYGDHERYETTYFK-PF----AGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQCAE 563


                   ....*..
gi 1827387616 1460 SVVVGVE 1466
Cdd:PLN02654   564 AAVVGIE 570

PTZ00342

acyl-CoA synthetase; Provisional

238-382

2.74e-04

acyl-CoA synthetase; Provisional

Pssm-ID: 240370 [Multi-domain] Cd Length: 746 Bit Score: 46.64 E-value: 2.74e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  238 TSLRLIQTGGEALTPPVARDLMVRLpGTRLQNQYGPAEAS--IVVTIHRvtqDDRVIPIG---TPTRRVSARVLDA--AL 310
Cdd:PTZ00342   461 PNLEVILNGGGKLSPKIAEELSVLL-NVNYYQGYGLTETTgpIFVQHAD---DNNTESIGgpiSPNTKYKVRTWETykAT 536

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827387616  311 REVPigvPGELYLGGVQLARGYAGRPDLTAERFVADPFgepgarlYRTGDRARWNRDGEIEYLGRTDFQVKL 382
Cdd:PTZ00342   537 DTLP---KGELLIKSDSIFSGYFLEKEQTKNAFTEDGY-------FKTGDIVQINKNGSLTFLDRSKGLVKL 598

PLN02430

long-chain-fatty-acid-CoA ligase

117-402

3.45e-04

long-chain-fatty-acid-CoA ligase

Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 46.35 E-value: 3.45e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  117 PTRPANAAFTLFTSGSTGRPKAVVITHRGIANRL-AADI--EQYD--LTARDVFLYKAPIT--FDVSVREIFLpiAIGAT 189
Cdd:PLN02430   216 PPKPLDICTIMYTSGTSGDPKGVVLTHEAVATFVrGVDLfmEQFEdkMTHDDVYLSFLPLAhiLDRMIEEYFF--RKGAS 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  190 LVIaepgRHGDPVHLADLIRRHGVTVIHFVPAMLAAFNEVLGAGVGELT------------------------------- 238
Cdd:PLN02430   294 VGY----YHGDLNALRDDLMELKPTLLAGVPRVFERIHEGIQKALQELNprrrlifnalykyklawmnrgyshkkaspma 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  239 --------------SLRLIQTGGEALTPPVARDLMVRLPGTRLQNqYGPAEASIVVTIhrvTQDDRVIPIGTPTrrVSAR 304
Cdd:PLN02430   370 dflafrkvkaklggRLRLLISGGAPLSTEIEEFLRVTSCAFVVQG-YGLTETLGPTTL---GFPDEMCMLGTVG--APAV 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  305 VLDAALREV------PIGVP--GELYLGGVQLARGYAGRPDLTAErFVADPFgepgarlYRTGDRARWNRDGEIEYLGRT 376
Cdd:PLN02430   444 YNELRLEEVpemgydPLGEPprGEICVRGKCLFSGYYKNPELTEE-VMKDGW-------FHTGDIGEILPNGVLKIIDRK 515

                          330       340
                   ....*....|....*....|....*..
gi 1827387616  377 DFQVKL-RGQRLELGEVEAALAAAPGV 402
Cdd:PLN02430   516 KNLIKLsQGEYVALEYLENVYGQNPIV 542

PRK00174

acetyl-CoA synthetase; Provisional

2591-3059

5.49e-04

acetyl-CoA synthetase; Provisional

Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 45.52 E-value: 5.49e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2591 RLTYRELDEASDRLARWLIGRGVG------------PERAVA-LAIGRsaqlLTAIWAVAKTGgayvpidpdYPAERVAS 2657
Cdd:PRK00174    98 KITYRELHREVCRFANALKSLGVKkgdrvaiympmiPEAAVAmLACAR----IGAVHSVVFGG---------FSAEALAD 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2658 MIEDSGAVL----------GLSV---------LASGDL---------PGQEFEWMRLDD----DSVAAEIAAVPAGPItD 2705
Cdd:PRK00174   165 RIIDAGAKLvitadegvrgGKPIplkanvdeaLANCPSvekvivvrrTGGDVDWVEGRDlwwhELVAGASDECEPEPM-D 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2706 AErlgevtaaNLAYVIYTSGSTGRPKGV-----------AVTHSGLanFARQESDRL--NA------GDNPVVLGfasP- 2765
Cdd:PRK00174   244 AE--------DPLFILYTSGSTGKPKGVlhttggylvyaAMTMKYV--FDYKDGDVYwcTAdvgwvtGHSYIVYG---Pl 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2766 SFDASVLEYllatvnEGTLAYrPSEAVGGEVLERfiaeHGAThTFLTPsvlstmdPTAVPSLrvIAAGGEAVPQ------ 2839
Cdd:PRK00174   311 ANGATTLMF------EGVPNY-PDPGRFWEVIDK----HKVT-IFYTA-------PTAIRAL--MKEGDEHPKKydlssl 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2840 ---------------------------PIVDRWapatelhnlyGPTETTiGITIS-----SAMRPGDPVRlggPIGGVDL 2887
Cdd:PRK00174   370 rllgsvgepinpeawewyykvvggercPIVDTW----------WQTETG-GIMITplpgaTPLKPGSATR---PLPGIQP 435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2888 MVLDERLRPVPVGMPGELYVAGG--ALSRG-YLDRsgltaERFTANPYGT-AGqrMYRTGDVVRWtpDTDtGGLTLeyTG 2963
Cdd:PRK00174   436 AVVDEEGNPLEGGEGGNLVIKDPwpGMMRTiYGDH-----ERFVKTYFSTfKG--MYFTGDGARR--DED-GYYWI--TG 503

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2964 RSDDQVKLRGLRIELGEIEAVLAEHDAV-ESAVVlGVGGSV-ATALAAYIVPVDGAVE----VSELKAFAGGRLPAYMVP 3037
Cdd:PRK00174   504 RVDDVLNVSGHRLGTAEIESALVAHPKVaEAAVV-GRPDDIkGQGIYAFVTLKGGEEPsdelRKELRNWVRKEIGPIAKP 582

                          570       580
                   ....*....|....*....|..
gi 1827387616 3038 SSFTVIDELPLTPVGKLDKRAL 3059
Cdd:PRK00174   583 DVIQFAPGLPKTRSGKIMRRIL 604

PRK00174

acetyl-CoA synthetase; Provisional

1342-1527

5.92e-04

acetyl-CoA synthetase; Provisional

Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 45.52 E-value: 5.92e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1342 TAGKPVTIGKPVDGFTVRVLDGRLHEVPQGVVGELYLSTA--GLARGYLGRPGQtavsFVADPFGE-PGarMYATGDLVR 1418
Cdd:PRK00174   419 TPLKPGSATRPLPGIQPAVVDEEGNPLEGGEGGNLVIKDPwpGMMRTIYGDHER----FVKTYFSTfKG--MYFTGDGAR 492

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1419 VAKGGNLEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGV-ESTRGgrkhTEVVAYLVAKPGATIDsaavlDE 1497
Cdd:PRK00174   493 RDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVGRpDDIKG----QGIYAFVTLKGGEEPS-----DE 563

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1827387616 1498 AAQHLAAHMV--------PSQAIVIDEIPLTPAGKLDR 1527
Cdd:PRK00174   564 LRKELRNWVRkeigpiakPDVIQFAPGLPKTRSGKIMR 601

hsFATP4_like

cd05939

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...

331-446

6.12e-04

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 45.11 E-value: 6.12e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616  331 GYAGRPDlTAERFVADPFgEPGARLYRTGDRARWNRDGEIEYLGRTDFQVKLRGQRLELGEVEAALAAAPGVLHAAAAVV 410
Cdd:cd05939    328 GYVNEGA-TNKKIARDVF-KKGDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGV 405

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1827387616  411 DGPGGQQLVGYLAPAD----VDVDTVAATTAELLPEYMRP 446
Cdd:cd05939    406 EVPGVEGRAGMAAIVDperkVDLDRFSAVLAKSLPPYARP 445

LC-FACS_euk

cd05927

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...

1062-1222

8.02e-04

Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 44.90 E-value: 8.02e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1062 MDYDEFETRTNAIARALLARGV--SPEDVVAVGMERSIGSVLATWGVIKSGAAYVPVDPAYPADRIAYMLEDSGATVGIT 1139
Cdd:cd05927      6 ISYKEVAERADNIGSALRSLGGkpAPASFVGIYSINRPEWIISELACYAYSLVTVPLYDTLGPEAIEYILNHAEISIVFC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1140 DAStrarlgesscewVDLADLEaeaesgdDITDTERNGSVRLT-----NLAYLIYTSGSTGRPKAVGVSHTGIVDFVNSL 1214
Cdd:cd05927     86 DAG------------VKVYSLE-------EFEKLGKKNKVPPPppkpeDLATICYTSGTTGNPKGVMLTHGNIVSNVAGV 146


                   ....*...
gi 1827387616 1215 AKITTGTP 1222
Cdd:cd05927    147 FKILEILN 154

PRK05851

long-chain-fatty acid--ACP ligase MbtM;

1349-1529

8.38e-04

long-chain-fatty acid--ACP ligase MbtM;

Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 44.76 E-value: 8.38e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1349 IGKPVDGFTVRVLDGrlhEVPQGV----VGELYLSTAGLARGYLGrpgqtavsfvADPfGEPGArMYATGDLVRVAKGGn 1424
Cdd:PRK05851   347 LGNPIPGMEVRISPG---DGAAGVagreIGEIEIRGASMMSGYLG----------QAP-IDPDD-WFPTGDLGYLVDGG- 410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 1425 LEFAGRADHQVKINGQRVELGEIEAVLDAQPGVAQSVVVGVESTRGGRKHTEVVAYLVAKPgatiDSAAVLDEAAQHLAA 1504
Cdd:PRK05851   411 LVVCGRAKELITVAGRNIFPTEIERVAAQVRGVREGAVVAVGTGEGSARPGLVIAAEFRGP----DEAGARSEVVQRVAS 486

                          170       180
                   ....*....|....*....|....*....
gi 1827387616 1505 H--MVPSQAIVID--EIPLTPAGKLDRAA 1529
Cdd:PRK05851   487 EcgVVPSDVVFVApgSLPRTSSGKLRRLA 515

PKS_PP

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...

1549-1607

1.11e-03

Pssm-ID: 214834 [Multi-domain] Cd Length: 86 Bit Score: 40.31 E-value: 1.11e-03

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827387616  1549 EDNLARIVAGLLG---EERVSVTESFFALGGDSIMSIQLSSA-AKAAGIHLSPREIFELKTIR 1607
Cdd:smart00823   14 LDLVREQVAAVLGhaaAEAIDPDRPFRDLGLDSLMAVELRNRlEAATGLRLPATLVFDHPTPA 76

hsFATP4_like

cd05939

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...

2589-3059

1.17e-03

Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 44.34 E-value: 1.17e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2589 GARLTYRELDEASDRLARWLIGRGVGPERAVALAIGRSAQLLtAIW-AVAKTGGAYVPIDPDYPAERVASMIEDSGAVlg 2667
Cdd:cd05939      1 DRHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFV-ALWlGLAKIGVETALINSNLRLESLLHCITVSKAK-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2668 lSVLasgdlpgqefewMRLDDDSVAAEIAAVPAGPITDAErlgevtaANLAYvIYTSGSTGRPKGVAVTHS--------G 2739
Cdd:cd05939     78 -ALI------------FNLLDPLLTQSSTEPPSQDDVNFR-------DKLFY-IYTSGTTGLPKAAVIVHSryyriaagA 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2740 LANFARQESDRL--------NAGD-----NPVVLG--------FASPSF-------DASVLEY-------LLATvnegtl 2784
Cdd:cd05939    137 YYAFGMRPEDVVydclplyhSAGGimgvgQALLHGstvvirkkFSASNFwddcvkyNCTIVQYigeicryLLAQ------ 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2785 AYRPSE-------AVGG--------EVLERF----IAE-HGATHTfltPSVLSTMDPtavpslRVIAAGgeavpqpIVDR 2844
Cdd:cd05939    211 PPSEEEqkhnvrlAVGNglrpqiweQFVRRFgipqIGEfYGATEG---NSSLVNIDN------HVGACG-------FNSR 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2845 WapateLHNLYgptettigitissamrpgdPVRL-------GGPIGGVDLMVLdeRLRPvpvGMPGELY---VAGGALSR 2914
Cdd:cd05939    275 I-----LPSVY-------------------PIRLikvdedtGELIRDSDGLCI--PCQP---GEPGLLVgkiIQNDPLRR 325

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2915 --GYLDRsGLTAERFTANPYgTAGQRMY------------------RTGDVVRWtpdtdtggltleytgrsddqvklRGL 2974
Cdd:cd05939    326 fdGYVNE-GATNKKIARDVF-KKGDSAFlsgdvlvmdelgylyfkdRTGDTFRW-----------------------KGE 380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827387616 2975 RIELGEIEAVLAEHDAVESAVVLGV--GGSVATALAAYIVPVDGAVEVSELKAFAGGRLPAYMVPSSFTVIDELPLTPVG 3052
Cdd:cd05939    381 NVSTTEVEGILSNVLGLEDVVVYGVevPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQFIRLLPEVDKTGTF 460


                   ....*..
gi 1827387616 3053 KLDKRAL 3059
Cdd:cd05939    461 KLQKTDL 467

entF