|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
15-714 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1329.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 15 DYHALNAMLNLYDREGRIQFGKDREAVEAFFAAHVRPNSVVFGSQQERLDWLVKEGYYEERVLTRYDRAFVVTLFERAHA 94
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 95 SGFRFQTFLGAWKYYTSYTLKTFDGKRYLESFEDRVVMVALTLAQGDEVLAERLTQEILSGRFQPATPTFLNCGKAQRGE 174
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERIYGKAFGEVAISELYDEL 334
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 335 VADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIAGRINMSNLCSEILQVNSASSYDENLDYADVGKDIS 414
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 415 CNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSDMSHIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFT 494
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 495 NLYFYTIAWHALHTSMRLARERNQRFAGFERSRYASGEYFSQYLEGDWQPKTEKVRALFEraGITLPTREMWQQLRDDVM 574
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELFE--GIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 575 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGPEKIIDTYAEAT 654
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 655 KHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLRQLALEGTEIEGCVSCAL 714
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
55-705 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 760.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 55 VFGSQQERLDWlVKEGYYEERVLTrydrAFVVTLFERAHASGFRFQTFLGAWKYYTSYTLKTFDGKrYLESFEDRVVMVA 134
Cdd:COG0209 9 QYKSFSEKIKY-VEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 135 LTLAQGD-----EVLAERLTQEILSGRFQPATPTFLNCGKAqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAF 209
Cdd:COG0209 83 MGLAAAEkpedrEEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 210 LLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLG 289
Cdd:COG0209 162 NFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNIS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 290 VVIPDITFKLAKENADMALFSPYDVERIYGKAFGEvaISELYDELVADDRIRkKTINARDFFQTLAEIQFESGYPYIMYE 369
Cdd:COG0209 242 VWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVY-KTIKARELWRKILESAWETGEPGILFK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 370 DTVNRANPI--AGRINMSNLCSEILQVNSASsydenldyadvgKDISCNLGSLNIAHTM-----DSPDFGRTVETAIRGL 442
Cdd:COG0209 319 DTINRRNPLphLGVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 443 TAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAG 522
Cdd:COG0209 387 DNVIDINDY-PVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPA 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 523 FERSRYASGEYFSQYLEGDWqpktekvralferagiTLPTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSI 602
Cdd:COG0209 465 FEGSKYAKGILPFDKYLDDL----------------LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGI 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 603 HPIVSKIEIRKEGKTGRVYYPAPFM------------------------------TNENLALYQDAYEIGPEKIIDTYAE 652
Cdd:COG0209 529 EPIFSLVYVRKVLDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAA 608
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1820376330 653 ATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLRQLALEGTE 705
Cdd:COG0209 609 RQKHVDQAISKTLNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
126-695 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 614.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 126 FEDRVVMVALTLAQGDEVLAERLTQEILSGRFQPATPTFLNCGKaQRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGG 205
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGT-PRGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 206 GVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKT 285
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 286 LSLGVVIPDITFKLAKenadmalfspydveriygkafgevaiselydelvaddrirkktinaRDFFQTLAEIQFESGYPY 365
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 366 IMYEDTVNRANP--IAGRINMSNLCSEILQvNSASSYDENldyadvGKDISCNLGSLNIAHTMDSPDFGRTVETAIRGLT 443
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQ-PTSPSEDEP------GEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 444 AVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqrfagf 523
Cdd:cd01679 267 NVIDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 524 ersryasgeyfsqylegdwqpktekvralferagitlptremwqqlrddvmryGIYNQNLQAVPPTGSISYINHATSSIH 603
Cdd:cd01679 340 -----------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIE 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 604 PIVSKIEIRKEGKtGRVYYPAPFMTNEN--LALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQI 681
Cdd:cd01679 367 PITSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYF 445
|
570
....*....|....
gi 1820376330 682 YAWKKGIKTLYYIR 695
Cdd:cd01679 446 YAWKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
176-694 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 603.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPY---DVERIYGKAFgevaiSELYD 332
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEF-----EKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 333 ELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQVNSASSYdenldyadvg 410
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 411 kdISCNLGSLNIAHTMDSP------DFGRTVETAIRGLTAVSDMShIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 485 YGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFERSRYASGE-YFSQYLEGDWQPKTEKvralferagitlpTR 563
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGIlQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 564 EMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGKtgrvyypapfmtNENLALYQDAYEIGP 643
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1820376330 644 EKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYI 694
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-713 |
1.61e-112 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 357.11 E-value: 1.61e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 7 ERVIQATPD--YHALNAMLN-LYDREGRIQFGKDREAVEAFFaahvrpnsvvfGSQQErldwLVKEGYYEERVLTRYDRA 83
Cdd:PRK09209 75 ARVDLEEPEwtFFAARLYLNrLYKRASRNRFYDASEKYGSFV-----------GLQES----LAERGIYSNDLLKRYSKE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 84 FVVTLFERAHASGFRFQTFLGAWKYYTSYTLKTFDGKRYlESFEDRVVMVALTLAQgDEVLAER--LTQE---ILSGRFQ 158
Cdd:PRK09209 140 ELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLTIALYLMQ-NEPRERRmqLVKEaywALSNLYM 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 159 P-ATPTFLNCGKAQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKM 237
Cdd:PRK09209 218 TvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 238 LEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERI 317
Cdd:PRK09209 297 LNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKKV 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 318 --------YGKAFGEVAISELYDELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANP--IAGRINMSNL 387
Cdd:PRK09209 377 mgwyledfYDEKKGDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPnkHEGMIYSSNL 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 388 CSEILQVNSASSYDEnlDYADVGKDIS---------CNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSDMSHIrSVPSIE 458
Cdd:PRK09209 457 CTEIMQNMSPTVMIQ--EIISGGQIVItkqpgdfvvCNLSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQL-PVPQAT 533
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 459 AGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYASGEYfsqyl 538
Cdd:PRK09209 534 ITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGA-YPVFKGSDWQTGEY----- 607
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 539 egdwqpktekvralFERAGItlpTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIrKEGKTG 618
Cdd:PRK09209 608 --------------FERRGY---NSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYY-EEKKDY 669
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 619 RVYYPAPFMTNENLALYQD-AYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLR 697
Cdd:PRK09209 670 RRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTIRASELLDLHMTAWKEGLKTTYYVRST 749
|
730
....*....|....*.
gi 1820376330 698 QLalegtEIEGCVSCA 713
Cdd:PRK09209 750 DI-----DIEECEWCS 760
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
15-714 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1329.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 15 DYHALNAMLNLYDREGRIQFGKDREAVEAFFAAHVRPNSVVFGSQQERLDWLVKEGYYEERVLTRYDRAFVVTLFERAHA 94
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 95 SGFRFQTFLGAWKYYTSYTLKTFDGKRYLESFEDRVVMVALTLAQGDEVLAERLTQEILSGRFQPATPTFLNCGKAQRGE 174
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERIYGKAFGEVAISELYDEL 334
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 335 VADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIAGRINMSNLCSEILQVNSASSYDENLDYADVGKDIS 414
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 415 CNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSDMSHIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFT 494
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 495 NLYFYTIAWHALHTSMRLARERNQRFAGFERSRYASGEYFSQYLEGDWQPKTEKVRALFEraGITLPTREMWQQLRDDVM 574
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELFE--GIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 575 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGPEKIIDTYAEAT 654
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 655 KHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLRQLALEGTEIEGCVSCAL 714
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
55-705 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 760.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 55 VFGSQQERLDWlVKEGYYEERVLTrydrAFVVTLFERAHASGFRFQTFLGAWKYYTSYTLKTFDGKrYLESFEDRVVMVA 134
Cdd:COG0209 9 QYKSFSEKIKY-VEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 135 LTLAQGD-----EVLAERLTQEILSGRFQPATPTFLNCGKAqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAF 209
Cdd:COG0209 83 MGLAAAEkpedrEEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 210 LLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLG 289
Cdd:COG0209 162 NFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNIS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 290 VVIPDITFKLAKENADMALFSPYDVERIYGKAFGEvaISELYDELVADDRIRkKTINARDFFQTLAEIQFESGYPYIMYE 369
Cdd:COG0209 242 VWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVY-KTIKARELWRKILESAWETGEPGILFK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 370 DTVNRANPI--AGRINMSNLCSEILQVNSASsydenldyadvgKDISCNLGSLNIAHTM-----DSPDFGRTVETAIRGL 442
Cdd:COG0209 319 DTINRRNPLphLGVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 443 TAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAG 522
Cdd:COG0209 387 DNVIDINDY-PVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPA 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 523 FERSRYASGEYFSQYLEGDWqpktekvralferagiTLPTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSI 602
Cdd:COG0209 465 FEGSKYAKGILPFDKYLDDL----------------LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGI 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 603 HPIVSKIEIRKEGKTGRVYYPAPFM------------------------------TNENLALYQDAYEIGPEKIIDTYAE 652
Cdd:COG0209 529 EPIFSLVYVRKVLDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAA 608
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1820376330 653 ATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLRQLALEGTE 705
Cdd:COG0209 609 RQKHVDQAISKTLNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
126-695 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 614.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 126 FEDRVVMVALTLAQGDEVLAERLTQEILSGRFQPATPTFLNCGKaQRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGG 205
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGT-PRGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 206 GVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKT 285
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 286 LSLGVVIPDITFKLAKenadmalfspydveriygkafgevaiselydelvaddrirkktinaRDFFQTLAEIQFESGYPY 365
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 366 IMYEDTVNRANP--IAGRINMSNLCSEILQvNSASSYDENldyadvGKDISCNLGSLNIAHTMDSPDFGRTVETAIRGLT 443
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQ-PTSPSEDEP------GEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 444 AVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqrfagf 523
Cdd:cd01679 267 NVIDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 524 ersryasgeyfsqylegdwqpktekvralferagitlptremwqqlrddvmryGIYNQNLQAVPPTGSISYINHATSSIH 603
Cdd:cd01679 340 -----------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIE 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 604 PIVSKIEIRKEGKtGRVYYPAPFMTNEN--LALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQI 681
Cdd:cd01679 367 PITSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYF 445
|
570
....*....|....
gi 1820376330 682 YAWKKGIKTLYYIR 695
Cdd:cd01679 446 YAWKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
176-694 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 603.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPY---DVERIYGKAFgevaiSELYD 332
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEF-----EKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 333 ELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQVNSASSYdenldyadvg 410
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 411 kdISCNLGSLNIAHTMDSP------DFGRTVETAIRGLTAVSDMShIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 485 YGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFERSRYASGE-YFSQYLEGDWQPKTEKvralferagitlpTR 563
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGIlQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 564 EMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGKtgrvyypapfmtNENLALYQDAYEIGP 643
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1820376330 644 EKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYI 694
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
102-697 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 566.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 102 FLGAWKYYTSYTLKTFDGKRYLES---FEDRVVMVALTLAQGDEVLA-ERLTQEILSG-RFQPATPTFLNCGKAqRGELV 176
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESpqeAYMRVAMGLASLEPKDTRLAdAIRFYDLLSRlKISPATPTLFNAGTP-RGQLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 177 SCFLLRI-EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:TIGR02506 80 SCFLLDVtDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERIYGkAFGEvAISELYDELV 335
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYG-LYGE-EFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 336 ADDRIRKK--TINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA---GRINMSNLCSEILQVNSASSYDEnldyadvg 410
Cdd:TIGR02506 238 KDVEARKKirKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTDDSHKGE-------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 411 kDISCNLGSLNIAH-----TMDSPDFGRTVETAIRGLTAVSDMSHIRSVPSIEaGNAASHAIGLGQMNLHGYLAREGIAY 485
Cdd:TIGR02506 310 -TAVCNLASVNLANfvmedKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAK-SNQRRRSIGIGVMGLHDVLAKLGLPY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 486 GSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFERSRYASGEYFSQYLEGDWQPKTEKVralferagitlPTREM 565
Cdd:TIGR02506 388 DSEEARDLNDRIFEAIYYYAIKASAELAKEKG-PFPGFSGSKYAKGWLHPDTWEKTIDPKTSMA-----------PTEED 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 566 WQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGK----------------------------T 617
Cdd:TIGR02506 456 WEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSgeflipnkylmkeleelglwdadrrgdiV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 618 GRVYYPAPFMT--NENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIR 695
Cdd:TIGR02506 536 ENVGSPQPIAAipETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEEVTAKDLLKLLLLAWKKGLKTMYYCR 615
|
..
gi 1820376330 696 LR 697
Cdd:TIGR02506 616 SR 617
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-713 |
1.61e-112 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 357.11 E-value: 1.61e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 7 ERVIQATPD--YHALNAMLN-LYDREGRIQFGKDREAVEAFFaahvrpnsvvfGSQQErldwLVKEGYYEERVLTRYDRA 83
Cdd:PRK09209 75 ARVDLEEPEwtFFAARLYLNrLYKRASRNRFYDASEKYGSFV-----------GLQES----LAERGIYSNDLLKRYSKE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 84 FVVTLFERAHASGFRFQTFLGAWKYYTSYTLKTFDGKRYlESFEDRVVMVALTLAQgDEVLAER--LTQE---ILSGRFQ 158
Cdd:PRK09209 140 ELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLTIALYLMQ-NEPRERRmqLVKEaywALSNLYM 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 159 P-ATPTFLNCGKAQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKM 237
Cdd:PRK09209 218 TvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 238 LEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERI 317
Cdd:PRK09209 297 LNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKKV 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 318 --------YGKAFGEVAISELYDELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANP--IAGRINMSNL 387
Cdd:PRK09209 377 mgwyledfYDEKKGDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPnkHEGMIYSSNL 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 388 CSEILQVNSASSYDEnlDYADVGKDIS---------CNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSDMSHIrSVPSIE 458
Cdd:PRK09209 457 CTEIMQNMSPTVMIQ--EIISGGQIVItkqpgdfvvCNLSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQL-PVPQAT 533
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 459 AGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYASGEYfsqyl 538
Cdd:PRK09209 534 ITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGA-YPVFKGSDWQTGEY----- 607
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 539 egdwqpktekvralFERAGItlpTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIrKEGKTG 618
Cdd:PRK09209 608 --------------FERRGY---NSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYY-EEKKDY 669
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 619 RVYYPAPFMTNENLALYQD-AYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLR 697
Cdd:PRK09209 670 RRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTIRASELLDLHMTAWKEGLKTTYYVRST 749
|
730
....*....|....*.
gi 1820376330 698 QLalegtEIEGCVSCA 713
Cdd:PRK09209 750 DI-----DIEECEWCS 760
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-713 |
9.34e-98 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 318.29 E-value: 9.34e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 66 LVKEGYYEERVLTRYDRAFVVTLFERAHASGFRFQTFLGAWKYYTSYTLKTFDGKrYLESFEDRVVMVALTLA--QGDE- 142
Cdd:PRK07088 124 LVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYEGLKLLADRYLVKGFNRE-ILELPQERFMGIAMHLAipEGKEk 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 143 --VLAERLTQEILSGRFQPATPTFLNCGKAQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAP 220
Cdd:PRK07088 203 rvYYAKKFYDLLSELKATVATPTLSNAGTPFY-QLSSCFISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSE 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 221 IKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLA 300
Cdd:PRK07088 282 IRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 301 KENADMALFSPYDVERIYGKA----FGEVAISEL---YDELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVN 373
Cdd:PRK07088 362 EKRENWSLFDPHEIKKVKGYSledyYDEEDRKEFtkkYLECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVN 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 374 RANPI--AGRINMSNLCSEILQVNSASSY------DENLDYADV-----GKDISCNLGSLNIAHtMDSPDFGRTVETAIR 440
Cdd:PRK07088 442 KANPNkhKGMIYSSNLCHEIAQNMSESELleeeiiDENGYYEVVqkikaGDMVTCNLNSIVLGN-VDDEELEEVIPTQIR 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 441 GLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRF 520
Cdd:PRK07088 521 MLDNVISLNYY-PVPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKG-SY 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 521 AGFERSRYASGEYfsqylegdwqpktekvralFERAGItlpTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATS 600
Cdd:PRK07088 599 PAFKGSEWETGKY-------------------FERRGY---NSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTA 656
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 601 SIHPIVSK--IEIRKEGKTGRVyypAPFMTNENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINK 678
Cdd:PRK07088 657 GIDPVFKRffMEEKKGSFTPKT---APDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYITPEYKAKQILN 733
|
650 660 670
....*....|....*....|....*....|....*
gi 1820376330 679 AQIYAWKKGIKTLYYIRLRQLalegtEIEGCVSCA 713
Cdd:PRK07088 734 LYIEAWKQGVKTIYYVRNKSL-----EMDECTSCS 763
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-713 |
1.39e-96 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 317.08 E-value: 1.39e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 7 ERVIQATPDYHALNAMLNLYdregriQFGKDREAVEAffAAHVRpnsvvfgSQQERLDWLVKEGYYEERVLTRYDRAfvv 86
Cdd:PRK12364 158 ELTTQEAPDWEFIAARLLML------QFSKKLGKSLE--KLGIH-------SFYDKIKYLTEEGLYGSYILEHYSRE--- 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 87 tlfERAHASGF------RFQTFLGAWKYYTSYTLKTFDGkRYLESFEDRVVMVALTLA---QGDEVLAERLTQEILSG-R 156
Cdd:PRK12364 220 ---EIEEAAGFidperdKLFTYSGLDLLLKRYVIRTHSH-EPLESPQEMFLGIALHLAmpeKQDRMGWVKRFYDMLSKlK 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 157 FQPATPTFLNCGKAQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMK 236
Cdd:PRK12364 296 VTMATPTLSNARKPFH-QLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIK 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 237 MLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKE--NADMALFSPYDV 314
Cdd:PRK12364 375 LANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRDdiNQSWYLFCPHEI 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 315 ERIYGKA----FGEvAISELYDELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLC 388
Cdd:PRK12364 455 LTVKGYAledyYGE-EWEKRYLDCVNDARISKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKhkGMIYCSNLC 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 389 SEILQVNSASSY------DENLDYADV-----GKDISCNLGSLNIAH--TMDSPDFGRTVETAIRGLTAVSDMSHIrSVP 455
Cdd:PRK12364 534 TEIAQNMSAIETvsteieTEDGDTVVVtttrpGDFVVCNLASLSLGNidLEDEEELEEVVRTVVRALDNVIDLNFY-PVP 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 456 SIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFERSRYASGEYFs 535
Cdd:PRK12364 613 YAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKG-AYGYFEGSDWQTGAYF- 690
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 536 qylegdwqpkteKVRALferagitlpTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSK--IEIRK 613
Cdd:PRK12364 691 ------------RKRGY---------TSEEWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDPVMKRyfLEEKK 749
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 614 EGKTGRVyypAPFMTNENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYY 693
Cdd:PRK12364 750 GALMPRV---APELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITNEFTMRQVLDLYLLAWEEGVKTIYY 826
|
730 740
....*....|....*....|
gi 1820376330 694 IRLRQLalegtEIEGCVSCA 713
Cdd:PRK12364 827 VRSKSL-----EVEECESCS 841
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
115-712 |
4.74e-80 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 266.82 E-value: 4.74e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 115 KTFDGKRYL---ESFEDRVVMVALTLAQGDEVLAERLTQEILSGRFQPATPTFLNCGkAQRGELVSCFLLRIEDNMESIG 191
Cdd:PRK09102 26 KATLRDRYLlegESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGG-TDRGLPISCFLNYVEDSLEGIV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 192 RAVNSALQLSKRGGGVAFLLSNLREAGAPIKRiENQSSGVIP---VMKMLEDAFSyanQLGARQGAGAVYLHAHHPDILR 268
Cdd:PRK09102 105 NTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPfikVMDSLTLAIS---QGSLRRGSFAVYLDIEHPEIEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 269 FLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERIygkafgevaiselydelvaddrirkKTINAR 348
Cdd:PRK09102 181 FLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPKDKSVI-------------------------RTVKAR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 349 DFFQTLAEIQFESGYPYIMYEDTVNRANP----IAG-RINMSNLCSEILQVnsaSSYDENldyadvGKDIS--CNLGSLN 421
Cdd:PRK09102 236 DLWAKILETRIETGEPYLLFIDNVNRALPevykDLGlKVKASNLCSEITLP---TGIDHL------GEDRTavCCLSSLN 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 422 IAHTMDSPDFGRTVETAIRGLTAVsdMSH-IRSVPSI--EAGNAASH--AIGLGQMNLHGYLAREGIAYGSPEGLDFTNL 496
Cdd:PRK09102 307 LEYYDEWKDTDAFIEDLMRFLDNV--LQDfIDKAPDEmeRAKYSAMRerSVGLGVMGFHSYLQSKMIPFESVMAKQWNKK 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 497 YFYTIAWHALHTSMRLARERnqrfagfersryasGEyfsqylegdwqPKTEKVRALFERagitlptremwqqlrddvmry 576
Cdd:PRK09102 385 IFKHIREQADKASKELAKEK--------------GE-----------CPDAAGYGVMRR--------------------- 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 577 giyNQNLQAVPPTGSISYINHATS-SIHPIVSKIEIRKeGKTGRVYYPAP------------------------------ 625
Cdd:PRK09102 419 ---FSTKMAIAPTASISIILGNTSpGIEPIAANYYTHK-TLKGSFTVKNKyleklleekgkdtdevwssiltnegsvqhl 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 626 -FMTNENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIR--------- 695
Cdd:PRK09102 495 dFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLPANVPKRDLNKLHFEAWKKGVKSLYYQRsksvqradk 574
|
650 660
....*....|....*....|....*.
gi 1820376330 696 ---------LRQLALEGTEIEGCVSC 712
Cdd:PRK09102 575 vshdvlkkrLVEKSAFNRDYDECLAC 600
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
145-692 |
4.69e-78 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 257.55 E-value: 4.69e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 145 AERLTQEILSGRFQPATPTFLNCGKAQRGELVSCFLLRIED-NMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKR 223
Cdd:cd02888 1 ADEFFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDdSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 224 IENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKiRIKTLSLGVVIPDITFKLAKEN 303
Cdd:cd02888 81 TGGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKMKEEKTV-VLQNFNISVAVTDAFMEAVEND 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 304 ADMALFSPYDVERiygkafGEVAiselydelvaddrirkKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GR 381
Cdd:cd02888 160 EPWELRNPREPDT------GKVY----------------RTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPglGR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 382 INMSNLCSEILQvnsassydenLDYAdvgkdiSCNLGSLNIA---------HTMDSPDFGRTVETAIRGLTAVSDMSHIr 452
Cdd:cd02888 218 INATNPCGEQPL----------LPYE------SCNLGSINLSkfvknpfggASFDFERLREAVRLAVRFLDNVIDVNRY- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 453 SVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYASGE 532
Cdd:cd02888 281 PLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGP-FPLFDASRYLMLK 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 533 YFSQylegdwqpktekvralferagitlpTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIvskieir 612
Cdd:cd02888 360 VIVN-------------------------AKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI------- 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 613 kegktgrvyypapfmtnenlalyqdayeIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIK--T 690
Cdd:cd02888 408 ----------------------------FSPEDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGLKgiT 459
|
..
gi 1820376330 691 LY 692
Cdd:cd02888 460 VY 461
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-712 |
1.77e-76 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 261.97 E-value: 1.77e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 101 TFLGAWKYYTSYTLKTFDGKRyLESFEDRVVMVALTLAQGDEVLAERLTQ--EILSgRFQP--ATPTFLNcGKAQRGELV 176
Cdd:PRK08447 138 NYLGIKTLYDRYLIKDRNNNP-IELPQHMFMAIAMFLAQNELDPQKWAKKfyDVIS-KFEVmlATPTLSN-ARTTRHQLS 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 177 SCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGA 256
Cdd:PRK08447 215 SCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIA 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 257 VYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVE---RIYGKAFgevaiSELYDE 333
Cdd:PRK08447 295 VYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKdltELYGEEF-----EKRYLE 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 334 LVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQVN--------------SA 397
Cdd:PRK08447 370 YEKDEKIIKEYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAhaGIIRSSNLCTEIFQNTapnhykikiefedgSI 449
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 398 SSYDEN------------------LD------------YADVGKDISCNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSD 447
Cdd:PRK08447 450 EFFEEEelvtvdsgitkkakkitsLDslkgkkiyivekEKKDGKTAVCNLASINLSKINTKEDIERVVPIAIRMLDNVID 529
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 448 MSH--IRSVpsiEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFER 525
Cdd:PRK08447 530 LNFypNRKV---KATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKG-VYPDFEG 605
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 526 SRYASGEYfsqylegdwqP---KTEKVRALFERAGItLPTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSI 602
Cdd:PRK08447 606 SNWSKGIF----------PidkANEEAKKLVERGGL-FDSACDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTI 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 603 HPiVSKIEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFP-DTATTRDINKAQI 681
Cdd:PRK08447 675 EP-VYKRKWFEENLSGLIPVVVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKASGKYLNEIYT 753
|
650 660 670
....*....|....*....|....*....|....*.
gi 1820376330 682 YAWKKGIKTLYYIR-----LRQLALEGTEIEgCVSC 712
Cdd:PRK08447 754 LAWKLGLKSTYYLRsespeSEEVSVADRSIE-CEGC 788
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
112-692 |
1.27e-74 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 251.86 E-value: 1.27e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 112 YTLKTFDGkRYLESFEDRVVMVALTLAQGD--------EVLAERLTQEILSGRFQPATPTFLNCGKAQRGELVSCFLLRI 183
Cdd:TIGR02504 6 YLLKDEDG-NIIESPEDLFRRVARALAAAEdkynspvwKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFVLPV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 184 EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHH 263
Cdd:TIGR02504 85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 264 PDILRFLDTKRENadEKIRIKTLSLGVVipDITFKLAKENADMALFSPYDVERiygkafgevaiselydelvaddrirkK 343
Cdd:TIGR02504 165 PDIEEFIEAKAKE--GKLQNFNISVGVT--DEFMEAVENDEEYELRNPRTGEY--------------------------K 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 344 TINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQvnsassydenLDYAdvgkdiSCNLGSLN 421
Cdd:TIGR02504 215 EVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPygGRINATNPCGEQPL----------LPYE------SCNLGSIN 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 422 IA----------HTMDSPDFGRTVETAIRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGL 491
Cdd:TIGR02504 279 LAkfvkndfgdeASFDFERLREVVRLATRFLDNVIDINVF-PLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEAR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 492 DFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYasgeyfsqylegdwqPKTEKVRALFERAGITLPTREMWqqlrd 571
Cdd:TIGR02504 358 ELAEEVMEFIADAAYRASAELAKERGA-FPLYDASKY---------------PMGRAMGARIPSALPAEIREAIR----- 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 572 dvmRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGKTG---------------RVYYPAPFMT-------- 628
Cdd:TIGR02504 417 ---KYGIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNVTVGGellevnplvelalreLGYYSDEIVKyvdekgtv 493
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820376330 629 ------NENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIK--TLY 692
Cdd:TIGR02504 494 egapgpEELPKVFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVEDVKAVYLEAWKLGLKgiTVY 565
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-707 |
6.77e-72 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 252.95 E-value: 6.77e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 101 TFLGAWKYYTSYtLKTFDGKRyLES---FEDRVVMvALTLAQGDEVLAERLT-QEILSG-RFQPATPTFLNCGkAQRGEL 175
Cdd:PRK12365 379 SYMGVQNLYDRY-FNHHEGRR-LETpqiFWMRVSM-GLALNEGQDKTSWAITfYNLLSTfRYTPATPTLFNSG-MRHSQL 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:PRK12365 455 SSCYLSTVQDDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAV 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERI---YGKAFGEvaISELYD 332
Cdd:PRK12365 535 CVYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLheaYGEEFEK--LYEEYE 612
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 333 ELVADDRIR-KKTINARDFFQTLAEIQFESGYPYIMYEDTVN--RANPIAGRINMSNLCSEILqVNSASSydenldyadv 409
Cdd:PRK12365 613 RKVDTGEIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNirSAQDHKGVVRCSNLCTEIL-LNCSET---------- 681
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 410 gKDISCNLGSLNIAH-----TMDSPDFGRTVETAIRGLTAVSDmshIRSVPSIEAGNA--ASHAIGLGQMNLHGYLAREG 482
Cdd:PRK12365 682 -ETAVCNLGSINLVEhivndGLDEEKLSETISIAIRILDNVID---INFYPTKEAKEAnlAHRAIGLGVMGFQDALYKLN 757
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 483 IAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYASGeyfsqYLEGDwqpkteKVRALFERAG----- 557
Cdd:PRK12365 758 ISYASQEAVEFADYSSELIAYYAILASSLLAKERGT-YSSYKGSKWDRG-----YLPID------TIELLKEYRGeanll 825
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 558 ITLPTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIrKEGKTGRVYYPAPFMTNE--NLALY 635
Cdd:PRK12365 826 MDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFV-KSNLSGEFTIPNVYLIEKlkKLGIW 904
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 636 QD-----------------------------AYEIGPEKIIDTYAEATKHVDQGLSLTLFF--PDtatTRDINKAQIYAW 684
Cdd:PRK12365 905 DAdmlddlkyfdgslleieripdhlkkifltAFEIEPEWIIECASRRQKWIDMGQSLNLYLaePD---GKKLSNMYLTAW 981
|
650 660
....*....|....*....|...
gi 1820376330 685 KKGIKTLYYIRlrqlALEGTEIE 707
Cdd:PRK12365 982 KKGLKTTYYLR----SSAATSVE 1000
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
67-714 |
4.60e-63 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 224.21 E-value: 4.60e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 67 VKEGYYEERVLTRYDRAFVVTLFERA-HASGFRFqTFLGAWKYYTSYTLKTFDGKRYLESFEDRVVMVALTLAQgDEVLA 145
Cdd:PHA02572 108 VNEGKYDPEILSKYSAEEITYLESFIdHDRDFEF-TYAGAMQLKEKYLVQDRSTGEIYETPQFAYMLIAMALHQ-DEPKE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 146 ERLT------QEILSGRFQPATPTFLNCGKAQRgELVSCFLLRIEDNMESIGRAVNSALQ-LSKRGGgVAFLLSNLREAG 218
Cdd:PHA02572 186 DRLEhvirfyNAVSTRKISLPTPIMAGVRTPTR-QFSSCVVIESGDSLDSINKTAMAIVKyISKRAG-IGINAGMIRAEG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 219 APIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFK 298
Cdd:PHA02572 264 SKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYE 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 299 LAKENADMALFSPYDV-ERIYGKAF-GEVAISELYDELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRAN 376
Cdd:PHA02572 344 RFIKNDYITLFSPHDVgGELYDAYFaDQDRFRELYEALEKDPSVRKKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHS 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 377 PIAGRINMSNLCSEI-LQVNSASSYDENldyADVGkdiSCNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSDMshiRSVP 455
Cdd:PHA02572 424 PFKDPIRQSNLCCEIaLPTKPLNHIDGE---GEIA---LCTLSAIVLGNFEDQDEIEELAEVAVRALDNLLDY---QDYP 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 456 SIEAGNA-ASHAIGLGQMNLHGYLAREGIAYGSPEGlDFTNLYFYTIAWHALHTSMRLARERnqrfaG----FERSRYAS 530
Cdd:PHA02572 495 VPAALKAkKRRSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEK-----GaceyFSDTKYSR 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 531 GEyfsqyLEGDWQPKTEKVralferagITLPTREM-WQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKI 609
Cdd:PHA02572 569 GE-----LPIDWYKKKVDE--------LVAPKYNCdWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPV 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 610 EIrKEGKTGRVYYPAP-FMTNENL-ALYQDAYEIGPEKIIDTYAEATKHVDQGLSL-TLFFPDTATTRDINKAQI----- 681
Cdd:PHA02572 636 SI-KKSKEGPFNQVVPnVETLKDLyDLLWDLAKKGNKGYLTQVAIMQKFVDQAISAnTSYDPENYPNGKVPMSVMlddll 714
|
650 660 670
....*....|....*....|....*....|....*....
gi 1820376330 682 YAWKKGIKTLYYIRLR------QLALEGTEIEGCVSCAL 714
Cdd:PHA02572 715 YFYYYGGKTLYYHNTRdgkgteDYEIETPKAEDCDSCKL 753
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-697 |
1.61e-58 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 212.48 E-value: 1.61e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 66 LVKEGYYEERVLTRYDRAFVVTLFERAHASGFRFqtfLGAWKYYTSYTLKTFDGKRyLES---FEDRVVMvALTLAQGDE 142
Cdd:PRK06539 117 GVAEGLLDSRLGGLFDLERLAAALDPTRDELLKY---IGVVTLNNRYGIRARNGDA-LEVpqyFWMRIAM-GLSLNEDDP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 143 V-LAERLTQEILSGRFQPATPTFLNCGKAQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 221
Cdd:PRK06539 192 TsSALAFYEKMSKLEYLAAGSTLVNAGTPY-PQLSNCFVMEMQDDIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPI 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 222 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAK 301
Cdd:PRK06539 271 RSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQ 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 302 ENADMALFSPY---DVERIYGKAFgevaiSELYDELVAD---DRIRK-KTINARDFFQT-LAEIQFESgYPYIMYEDTVN 373
Cdd:PRK06539 351 NDEDWYLFDPLetpDLNELYGKAF-----SKRYAQYVEQaeaGRIRMfKRITAREQFRAiLMSLQTTS-HPWLTWKDTIN 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 374 -RA-NPIAGRINMSNLCSEIlqvnsasSYDENLDYADVgkdisCNLGSLNIAHTMDSP--DFGRTVET---AIRGLTAVS 446
Cdd:PRK06539 425 nRAlNNNTGTIHLSNLCTEI-------CLPQDRDNVSV-----CNLASINLSRHLADGelDWAQLEEStrlAVRQLDNLI 492
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 447 DMShIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERS 526
Cdd:PRK06539 493 DIT-ASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAERGA-YPNFEGS 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 527 RYASGeyfsqYLEGDWQPKTEKVRALFERAGITlpTREMWQQLRDDVmRYGIYNQNLQAVPPTGSISYINHATSSIHPIV 606
Cdd:PRK06539 571 RWSRG-----MVPVDSIALLEADRGVPVDVNRT--TRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTTPGLDPQF 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 607 SKIEIR--KEGKTGRVyypapfmtNENL-----------------------------------ALYQDAYEIGPEKIIDT 649
Cdd:PRK06539 643 SQIFSRstSSGKFLEV--------NRNLvadlkelglwetvreeilrsqgdiqeiaaipdeikALYRTSFQLSPYAFLEV 714
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 1820376330 650 YAEATKHVDQGLSLTLFFpdtaTTRDI-NKAQIY--AWKKGIKTLYYIRLR 697
Cdd:PRK06539 715 AARAQKWVDQAISRNMYL----ESRDIgDMMDIYtaAWEMGVKTTYYLHMK 761
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
151-705 |
2.18e-53 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 198.65 E-value: 2.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 151 EILSG-RFQPATPTFLNCGkAQRGELVSCFLLRIEDNMESIGRAV-NSALqLSKRGGGVAFLLSNLREAGAPIKRIENQS 228
Cdd:PRK07207 347 NLLSSfDFMSSTPTLFNSG-TLRPQLSSCYLTTVPDDLDGIYEAIkDNAL-LSKFAGGLGNDWTPVRALGSHIKGTNGKS 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 229 SGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMAL 308
Cdd:PRK07207 425 QGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTL 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 309 FSPYDV---ERIYGKAFgEVAISElYDELVADDRIRK-KTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPI--AGRI 382
Cdd:PRK07207 505 FSPSEVpdlHDLFGKAF-EEAYTA-YEAKAARGEIKLfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQqhVGVV 582
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 383 NMSNLCSEIlQVNsaSSYDEnldyadvgkdIS-CNLGSLNI-AHTMDSPD-----FGRTVETAIRGLTAVSDMSHIrSVP 455
Cdd:PRK07207 583 HSSNLCTEI-TLN--TSDDE----------IAvCNLGSVNLvAHIKDGAKldhekLKRTVSTAMRMLDNVIDINYY-AVP 648
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 456 SIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFERSRYASGeyfs 535
Cdd:PRK07207 649 KARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERG-RYSSYEGSLWSRG---- 723
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 536 qYLEGDWQPKTEKVRALFerAGITLPTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP----------- 604
Cdd:PRK07207 724 -ILPIDSLKLLAEARGGY--LEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPtyqnlyvksnl 800
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 605 -----IVSKIEIR--KE-------------------GKTGRVyyPApfmtnENLALYQDAYEIGPEKIIDTYAEATKHVD 658
Cdd:PRK07207 801 sgeftVVNPYLVRdlKArglwdevmvndlkyfdgslQRIDRI--PA-----DLKALYATAFEVDPRWLVEAASRRQKWID 873
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 1820376330 659 QGLSLTLFFpDTATTRDINkaQIY--AWKKGIKTLYYirLRQLALEGTE 705
Cdd:PRK07207 874 QAQSLNLYM-AGASGKKLD--ETYklAWLRGLKTTYY--LRTLGATHVE 917
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
149-700 |
4.27e-49 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 184.95 E-value: 4.27e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 149 TQEILSGR-FQPATPTFLNCGKAqRGELVSCFLLRI-EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIEN 226
Cdd:PLN02437 189 TYHLMSQRwFTHASPTLFNAGTP-RPQLSSCFLICMkDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNG 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 227 QSSGVIPVMKMLEDAFSYANQLGA-RQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENAD 305
Cdd:PLN02437 268 TSNGIVPMLRVFNDTARYVDQGGGkRKGAFAIYLEPWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGD 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 306 MALFSPYDVERI---YGKAFgevaiSELYDELVADDRIrKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--G 380
Cdd:PLN02437 348 WSLFCPNEAPGLadcWGEEF-----ERLYTKYEREGKA-KKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQnlG 421
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 381 RINMSNLCSEILQVNSAssydenlDYADVgkdisCNLGSL------------------NIAHTMDSP----DFGRTVE-T 437
Cdd:PLN02437 422 TIKSSNLCTEIIEYTSP-------TETAV-----CNLASIalprfvrekgvpleshpsKLVGSLGSKnryfDFEKLAEvT 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 438 AI--RGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLArE 515
Cdd:PLN02437 490 AVvtRNLNKIIDVNYY-PVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELA-A 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 516 RNQRFAGFERSRYASGEyfsqyLEGD-WqpktekvralferaGITLPTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISY 594
Cdd:PLN02437 568 REGPYETYAGSPVSKGI-----LQPDmW--------------GVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQ 628
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 595 INHATSSIHPIVSKIEIRKeGKTGR----------------VYYPA---------------PFMTNENLALYQDAYEIGP 643
Cdd:PLN02437 629 ILGNNECFEPYTSNIYSRR-VLSGEfvvvnkhllhdltemgLWTPTlknkiiaengsvqkiPEIPDDLKAIYKTVWEIKQ 707
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 1820376330 644 EKIIDTYAEATKHVDQGLSLTLFFPDtATTRDINKAQIYAWKKGIKT-LYYIRLRQLA 700
Cdd:PLN02437 708 RTLVDMAADRGCYIDQSQSLNIHMDQ-PNFGKLTSLHFYAWSKGLKTgMYYLRSRAAA 764
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
112-692 |
5.84e-48 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 180.90 E-value: 5.84e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 112 YTLKTFDGKRyLESFEDRVVMVALTLAQGD---------EVLAERLTQEILSGRFQPATPTFLNCGKAQrGELVSCFLLR 182
Cdd:PRK08665 24 YLKKDEDGKP-IETPEDMFRRVARTIAAAEliydskadvEALADRFYDLMTSLEFLPNSPTLMNAGREL-GQLSACFVLP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 183 IEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAH 262
Cdd:PRK08665 102 VGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRVD 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 263 HPDILRFLDTKRENADekirIKTLSLGVVIPDITFKLAKENADMALFSPYDveriygkafGEVAiselydelvaddrirk 342
Cdd:PRK08665 182 HPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT---------GEVV---------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 343 KTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSE--ILqvnsasSYDenldyadvgkdiSCNLG 418
Cdd:PRK08665 233 GRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPhlGEIESTNPCGEqpLL------PYE------------SCNLG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 419 SLNIAHTMDSPDF-----GRTVETAIRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDF 493
Cdd:PRK08665 295 SINLSKMVKNGDVdweklREVVHLAVRFLDNVIDANKY-PLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVEL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 494 TNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYAsgeyfsqylegdwQPKTEKVRalferagitlptremwqqlrddv 573
Cdd:PRK08665 374 AEKVMKFIQDEAHAASRELAEERGP-FPNYEGSIYD-------------KDGLGPMR----------------------- 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 574 mrygiyNQNLQAVPPTGSISYINHATSSIHPI--VSKI----------EI--------RKEG-----------KTGRV-- 620
Cdd:PRK08665 417 ------NATVTTIAPTGTISIIAGCSSGIEPLfaLSFTrnvmdgerlvEVnpvfeaaaKEEGfyseelmekiaEKGSIqd 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 621 --YYPAP----FMTnenlalyqdAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIK--TLY 692
Cdd:PRK08665 491 idEVPEDvrrvFVT---------AHDISPEWHVRMQAAFQKHTDNAVSKTVNFPNEATIEDVREVYRLAYELGCKgvTIY 561
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
150-692 |
2.99e-39 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 155.39 E-value: 2.99e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 150 QEILSGR-FQPATPTFLNCGkAQRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQS 228
Cdd:PRK06406 224 EEVMSNLkFVPNSPTLMNAG-TKLGQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 229 SGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTK-RENadekiriKTLSlgvvipdiTFKLAkenadma 307
Cdd:PRK06406 303 SGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSKdSEN-------KVLS--------NFNIS------- 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 308 lfspydveriygkafgeVAIS-ELYDELVADD-------RIRK--KTINARDFFQTLAEIQFESGYPYIMYEDTVNRANP 377
Cdd:PRK06406 361 -----------------VAVTdEFFDKLDNDDyyplrnpRNGKevKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNP 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 378 IA--GRINMSNLCSEilqvnsassyDENLDYAdvgkdiSCNLGSLNIAH-----TMDSPDFGRTVETAIRGLTAVSDMSH 450
Cdd:PRK06406 424 VKnlGEIESTNPCGE----------QPLLPYE------SCNLGSINLSKfvengKIDWDRLRETVHIATRFLDNVIDANK 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 451 IrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSryas 530
Cdd:PRK06406 488 F-PVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGV-FPAWYGS---- 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 531 geyfsqylegDWQPKTEKVRalferagitlptremwqqlrddvmrygiyNQNLQAVPPTGSISYINHATSSIHPIVSKIE 610
Cdd:PRK06406 562 ----------EWEKKGIKMR-----------------------------NSTTTTIAPTGTISIIAGCSSSIEPLFAIAF 602
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 611 IRK--------------EGKTGRV-YYPAPFM-------------TNENLA-LYQDAYEIGPEKIIDTYAEATKHVDQGL 661
Cdd:PRK06406 603 VRHvlngqellevnplfEEITRKRgLYSEELMrkvaetgnlqnidVPEDIKrIFVTAHEIDPQWHVLMQATFQRYCDSGV 682
|
570 580 590
....*....|....*....|....*....|....
gi 1820376330 662 SLTLFFPDTATTRDINKAQIYAWK---KGIkTLY 692
Cdd:PRK06406 683 SKTINLRYDATPEDIAKAYRLAKDlhcKGI-TVY 715
|
|
| RNR_N |
pfam08343 |
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ... |
16-97 |
1.07e-35 |
|
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyze the formation of deoxyribonucleotides. It occurs together with the RNR all-alpha domain (pfam00317) and the RNR barrel domain (pfam02867).
Pssm-ID: 429933 Cd Length: 82 Bit Score: 129.11 E-value: 1.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 16 YHALNAMLNLYDREGRIQFGKDREAVEAFFAAHVRPNSVVFGSQQERLDWLVKEGYYEERVLTRYDRAFVVTLFERAHAS 95
Cdd:pfam08343 1 YIALNNELNLYDENGKIQFDKDKEALEAYFKEHVNPNTVFFHSLKEKLDYLVENDYYEEEFLNKYSFEFIEELYKYAYSY 80
|
..
gi 1820376330 96 GF 97
Cdd:pfam08343 81 KF 82
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
177-693 |
5.32e-34 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 138.97 E-value: 5.32e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 177 SCFLLRIEDNMESIGrAVNSAL--QLSKRGG-GVAFllSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQG 253
Cdd:PRK09103 221 SCVLIECGDSLDSIN-ATSSAIvkYVSQRAGiGINA--GRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 254 AGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERIYGKAFGEVA-ISELYD 332
Cdd:PRK09103 298 AATLFYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDeFERLYT 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 333 ELVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRA---NPIAGRINMSNLCSEI------LQ-VNsassyDE 402
Cdd:PRK09103 378 KYEQDDSIRKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHspfDPKVAPVRQSNLCLEIalptkpLNdVN-----DE 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 403 NldyadvGKDISCNLGSLNIAHTMDSPDFGRTVETAIRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREG 482
Cdd:PRK09103 453 N------GEIALCTLSAFNLGAINSLDELEELADLAVRALDALLDYQDY-PIPAAKRGAMGRRTLGIGVINFAYYLAKNG 525
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 483 IAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNqRFAGFERSRYASGeyfsqYLEGDWQPKT-EKVralferagITLP 561
Cdd:PRK09103 526 VRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG-ACPWFNETTYAQG-----ILPIDTYKKDlDAI--------CNEP 591
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 562 TREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIEIrKEGKTGRVYYPAPfmtneNLALYQDAYEI 641
Cdd:PRK09103 592 LHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSI-KASKDGILKQVVP-----DYERLKDAYEL 665
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820376330 642 ---GPEKiiDTYAEAT----KHVDQGLSL------TLFFPDTATTRDINKAQIYAWKKGIKTLYY 693
Cdd:PRK09103 666 lweMPNN--DGYLQLVgimqKFVDQSISAntnydpSRFPSGKVPMKQLLKDLLTAYKFGVKTLYY 728
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
142-691 |
1.23e-28 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 122.77 E-value: 1.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 142 EVLAERLTQEILSGRFQPATPTFLNCGKAQRGELVSCFLLRIEDNMESIGR-AVNSALqLSKRGGGVAFLLSNLREAGap 220
Cdd:PRK06556 116 EIFEHELTWLLLHQKFSFNSPVWFNVGTESPQQVSACFILSVDDSMESILNwYKEEGM-LFKGGSGTGTNLSRIRSSK-- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 221 ikriENQSSGVI---PV--MKMLeDAFSYANQLGA--RQGAGAVYLHAHHPDILRFLDTK-REnaDEKIRIktlslgvvi 292
Cdd:PRK06556 193 ----ELLSGGGTasgPVsfMRGA-DASAGTIKSGGatRRAAKMVILDVDHPDIEEFIETKaKE--EDKIRA--------- 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 293 pditfkLAKENADMAlFSPYDVERI-YGKAFGEVAISELYDELVADD-----RIRK-----KTINARDFFQTLAEIQFES 361
Cdd:PRK06556 257 ------LRDAGYDMD-LGGEAYSSVqYQNANNSVRVSDEFMRAVENDgefglRARTdgeviETVDAKELFRKIAEAAWEC 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 362 GYPYIMYEDTVNR--ANPIAGRINMSNLCSEILqvnsassydeNLDyadvgkDISCNLGSLNIAH------TMDSPDFGR 433
Cdd:PRK06556 330 ADPGIQYDDTINDwhTCPESGRINASNPCSEYM----------FLD------NSSCNLASLNLMKflrddgTFDVESFRH 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 434 TVETAIrglTAVSDMSHIRSVPSiEAGNAASHA---IGLGQMNLHGYLAREGIAYGSPEGLDF----TNLyfytIAWHAL 506
Cdd:PRK06556 394 AVELVI---TAMEISICFADFPT-EKIARNTRAfrqLGLGYANLGALLMATGLPYDSDGGRALaaaiTSL----MTGEAY 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 507 HTSMRLArERNQRFAGFERSRyasgEYFSQYLE------GDWQPKTEKVRALFERAgitlptREMWQQLRDDVMRYGIYN 580
Cdd:PRK06556 466 RRSAELA-GVVGPFEGYARNA----EPHLRVMRkhaaanDAIRPLGEVDAALLEAA------KEAWDDALELGEKNGYRN 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 581 QNLQAVPPTGSISY-INHATSSIHPIVSKIEIRKEGKTG--------------RVYYP-------------------APF 626
Cdd:PRK06556 535 AQASVLAPTGTIGFmMDCDTTGIEPDFALVKYKKLVGGGsmkivnqtvpralkKLGYSeeqieaiveyiaehghiegAPG 614
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820376330 627 MTNENLALYQDAYE-------IGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQIYAWKKGIKTL 691
Cdd:PRK06556 615 LKPEHYAVFDCAMKpasgersISPMGHVRMMAAVQPFLSGAISKTVNMPEDATVEDIEEVYLEGWKLGLKAL 686
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
146-692 |
1.11e-23 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 106.85 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 146 ERLTQEILSGRFQPATPTFLNCGKAQRGELVSCFLLR-IEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRI 224
Cdd:PRK08115 157 EKFYQELVNMNFVPAGRVLYGAGSKTDVTYFNCYVMPfVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGV 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 225 ENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKREN-------------------ADEKIRIKT 285
Cdd:PRK08115 237 NGKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFIISKMQNprilryllentedeqikrlVKEKLKFTP 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 286 LSL-------GVV----IPD----------------------------------ITFKLAKE-------NADMALFSPyD 313
Cdd:PRK08115 317 LSEveeamyqAIVnyknIEGqggfdtkvikeaenklrtggtytvnnpefltganISVCLTKEfmeavenDEEYELRFP-D 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 314 VE-------RIYGKAFGEVAISELYDELVADDRIRKkTINARDFFQTLAEIQFESGYPYIMYEDTVN---RANPIAGRIN 383
Cdd:PRK08115 396 VEnyteeemEIYNEEWHEVGDVREWEKMGYPVRTYR-KIKAKELWNLINICATYSAEPGIFFIDNANemtNAKAYGQKVV 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 384 MSNLCSEilqvNSASSYDenldyadvgkdiSCNLGSLNIAH-------TMDSPDFGRTVETAIRGLTAVSDmshirSVPS 456
Cdd:PRK08115 475 ATNPCGE----QPLAPYS------------VCNLAAINLANmadketkTVDYEKLKRTVEVGVRMQDNVID-----ATPY 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 457 IEAGNA----ASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERnqrfagfersryasGE 532
Cdd:PRK08115 534 FLEENKkqalGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEK--------------GS 599
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 533 YfsQYLEGDWQPKTEKVRALFERAGItlpTREMWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVS----- 607
Cdd:PRK08115 600 F--PFLVGQTEEETAKLREAFINTGY---MKKMPEDIREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSfsyyr 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 608 ----------KIEIRKEGKTGrvyYPAPfMTNENLALYQDAYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDIN 677
Cdd:PRK08115 675 sgrlgkfievKADIVQEYLDK---HPEA-DENHLPEWFISAMELKPEAHADVQCIIQRWVDSSLSKTVNAPKGYTVEQVQ 750
|
650
....*....|....*..
gi 1820376330 678 KAQIYAWKKGIK--TLY 692
Cdd:PRK08115 751 KVYERLYRGGAKggTVY 767
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
166-695 |
3.35e-22 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 101.41 E-value: 3.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 166 NCGKAQRGELVSCFL--LRIEDNMESIGRAVNSALQLSKR----GGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLE 239
Cdd:PRK06948 76 NAGAAPDQTMVNCFVhpIRAPAALTAVHPNLDRALDDARLtllmGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 240 DAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENAdekiRIKTLSLGVVIPDITFKLAKENADMALFSPYDVERIYG 319
Cdd:PRK06948 156 RICAALPFRDGRRGAQMAVLRCDHPDLLAFVAAKRGRA----RWTTFNLSVAVTDAFMQAVAQDLPWALRHRAPPRRAAG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 320 KAFgevaiselydeLVADDRIRKKTINARDFFQTLAEIQFESGYPYIMYEDTVNRANPIAG--RINMSNLCSEilqvNSA 397
Cdd:PRK06948 232 GAL-----------RGADGAWTYATVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREheRIDATNPCGE----QPL 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 398 SSYDenldyadvgkdiSCNLGSLNIAH------------TMDSPDFGRTVETAIRGLTAVSDMS------HIRsvpsiEA 459
Cdd:PRK06948 297 PPYG------------SCVLGPIDLSRfvrhpfgvggepRFDFAALATAVRIQVRMLDNALDLTrwplaaHAR-----EA 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 460 gnAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYASGeyfsqyle 539
Cdd:PRK06948 360 --RQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGA-YPLCDPAAHLDA-------- 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 540 gdwqpktekvralfERAGITLPtremwQQLRDDVMRYGIYNQNLQAVPPTGSIS--YINHATSSIHPIVSKIEIRK-EGK 616
Cdd:PRK06948 429 --------------LRAGPPLP-----HAVCHAIARHGLRNSHLLSFAPVGSVSlaFGDNCSPGIEPARAWIEHRPvRAG 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 617 TGRVyypaPFMTNENLA--LYQD--------------AYEIGPEKIIDTYAEATKHVDQGLSLTLFFPDTATTRDINKAQ 680
Cdd:PRK06948 490 AGGA----RGMRAENHAyrLFRSlrgeraalpdyfvtAADVAPADHLAMRAALQPYVDAGISKTVTLPNHYSLAEVDALL 565
|
570
....*....|....*
gi 1820376330 681 IYAWKKGIKTLYYIR 695
Cdd:PRK06948 566 FQAWRAGLKGITIFR 580
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
414-708 |
5.89e-18 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 89.05 E-value: 5.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 414 SCNLGSLNIAHTM----------DSPDFGRTVETAIRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGI 483
Cdd:PRK08332 1307 SCNLASINLAKFVkydengkpyfDWDEYAYVIQKVAKYLDNAIDVNKF-PLPEIDYNTKLTRRIGVGMMGLADALFKLGI 1385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 484 AYGSPEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSRYASGEYfsqYLEGDWQPKTekvralferagITLPtr 563
Cdd:PRK08332 1386 PYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGT-FPLYEKTEYPKGEL---PVEGFYHPEI-----------WNLP-- 1448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 564 emWQQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVSKIeIRKEGKTGRVYYPAPFMTNE--NLALYQDayEI 641
Cdd:PRK08332 1449 --WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPVFEAElkKRGLYSE--EL 1523
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 642 gPEKIIDTYAEAtkhvdQGL-------------------------------------SLTLFFPDTATTRDINKAQIYAW 684
Cdd:PRK08332 1524 -LKKISDNYGSV-----QGLeeipedmqrvfvtaldihwldhilaqaniqmwltdsaSKTINMINEATVEDVKAAYLIAH 1597
|
330 340
....*....|....*....|....
gi 1820376330 685 KKGIKTLYYIRLRQLALEGTEIEG 708
Cdd:PRK08332 1598 FLGCKGVTVYRDGSLSVQVYSVEG 1621
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
101-170 |
3.00e-14 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 68.03 E-value: 3.00e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820376330 101 TFLGAWKYYTSYTLKTFDGKRYlESFEDRVVMVALTLAQ-----GDEVLAERLTQEILSGRFQPATPTFLNCGKA 170
Cdd:pfam00317 2 TYLGAKVLEDRYLLKDEDGELL-ETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
343-527 |
1.04e-08 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 58.82 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 343 KTINARDFFQTLAEIQFESGYPYIMYEDTVN--RANPIAGRINMSNLCSEILqvnsassydeNLDyadvgkDISCNLGSL 420
Cdd:PRK07562 429 KTLKARDLWEKIGYAAWASADPGLQFNTTINdwHTCPASGPIRASNPCSEYM----------FLD------DTACNLASL 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 421 NIAH-------TMDSPDFgrtvETAIRGLTAVSD----MSHIrsvPSIEAGNAAS--HAIGLGQMNLHGYLAREGIAYGS 487
Cdd:PRK07562 493 NLLTfrdedtkRFDVEAY----EHACRLWTVVLEisvlMAQF---PSKEIAELSYefRTLGLGYANIGGLLMTMGIPYDS 565
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1820376330 488 PEGLDFTNLYFYTIAWHALHTSMRLARERNQrFAGFERSR 527
Cdd:PRK07562 566 DEGRAICGALSAIMTGVAYATSAEMAKELGP-FPGYEKNA 604
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
157-206 |
7.91e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.38 E-value: 7.91e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1820376330 157 FQPATPTFLNCGKAQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGG 206
Cdd:PRK08332 253 FMPNTPALINSGRPL-GMLSACFVVPIEDDMESIMKAAHDVAMIQKAGGG 301
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
211-388 |
8.32e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.38 E-value: 8.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 211 LSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIrIKTLSLGV 290
Cdd:PRK08332 760 FSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNV-LSNFNISV 838
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820376330 291 VIPDITFKLAKENADMALFSPYDveriygkafGEVAiselydelvaddrirkKTINARDFFQTLAEIQFESGYPYIMYED 370
Cdd:PRK08332 839 GIWEDFWEALKEGKKYPLINPRT---------GEVV----------------KEIDPKSLFEELAYMAWAKADPGVIFFD 893
|
170 180
....*....|....*....|..
gi 1820376330 371 TVNRANPI----AGRINMSNLC 388
Cdd:PRK08332 894 VINRRNVLkeakGGPIRATNPC 915
|
|
| |
