type II secretion system F family protein [Desulfovibrio sp. JC010]
Protein Classification
type II secretion system F family protein( domain architecture ID 1001577)
type II secretion system (T2SS) F family protein similar to Thermus thermophilus PilC type IV pilus biogenesis protein and Vibrio Cholerae toxin coregulated pilus biosynthesis protein E (TcpE)
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| PulF super family | cl34272 | Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, ... |
13-281 | 2.27e-13 | |||||
Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]; The actual alignment was detected with superfamily member COG1459: Pssm-ID: 441068 [Multi-domain] Cd Length: 399 Bit Score: 70.53 E-value: 2.27e-13
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| Name | Accession | Description | Interval | E-value | |||||
| PulF | COG1459 | Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, ... |
13-281 | 2.27e-13 | |||||
Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]; Pssm-ID: 441068 [Multi-domain] Cd Length: 399 Bit Score: 70.53 E-value: 2.27e-13
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| GspF | TIGR02120 | type II secretion system protein F; This membrane protein is a component of the terminal ... |
25-282 | 6.86e-07 | |||||
type II secretion system protein F; This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking] Pssm-ID: 273980 [Multi-domain] Cd Length: 399 Bit Score: 50.79 E-value: 6.86e-07
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| T4P_ComGB | NF041012 | competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive ... |
20-278 | 1.04e-06 | |||||
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive bacteria as part of a type IV pilus system used for DNA binding and uptake when species such as Streptococcus pneumoniae or Bacilus subtilis are in a competent state for natural transformation. Members of this family, typically called ComGB (second protein of the ComG operon), belong more broadly to the family of GspF, part of type 2 secretion systems (T2SS) in Gram-negative bacteria. Pssm-ID: 468941 [Multi-domain] Cd Length: 333 Bit Score: 49.78 E-value: 1.04e-06
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| PTP-MTMR5-like | cd14534 | protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related ... |
208-313 | 1.03e-04 | |||||
protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatases 5 and 13; This subgroup of enzymatically inactive phosphatase domains of myotubularins consists of MTMR5, also known as SET binding factor 1 (SBF1) and MTMR13, also known as SET binding factor 2 (SBF2), and similar domains. Beside the pseudophosphatase domain, they contain a variety of other domains, including a DENN and a PH-like domain. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. MTMR5 and MTMR13 are pseudophosphatases that lack the catalytic cysteine in their catalytic pocket. Mutations in MTMR13 causes Charcot-Marie-Tooth type 4B2, a severe childhood-onset neuromuscular disorder, characterized by demyelination and redundant loops of myelin known as myelin outfoldings, a similar phenotype as mutations in MTMR2. Mutations in the MTMR5 gene cause Charcot-Marie-tooth disease type 4B3. MTMR5 and MTMR13 interact with MTMR2 and stimulate its phosphatase activity. Pssm-ID: 350382 [Multi-domain] Cd Length: 274 Bit Score: 43.51 E-value: 1.03e-04
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| T2SSF | pfam00482 | Type II secretion system (T2SS), protein F; The original family covered both the regions found ... |
24-125 | 3.76e-04 | |||||
Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats). Pssm-ID: 425708 [Multi-domain] Cd Length: 119 Bit Score: 39.63 E-value: 3.76e-04
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| Name | Accession | Description | Interval | E-value | |||||
| PulF | COG1459 | Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, ... |
13-281 | 2.27e-13 | |||||
Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]; Pssm-ID: 441068 [Multi-domain] Cd Length: 399 Bit Score: 70.53 E-value: 2.27e-13
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| GspF | TIGR02120 | type II secretion system protein F; This membrane protein is a component of the terminal ... |
25-282 | 6.86e-07 | |||||
type II secretion system protein F; This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking] Pssm-ID: 273980 [Multi-domain] Cd Length: 399 Bit Score: 50.79 E-value: 6.86e-07
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| T4P_ComGB | NF041012 | competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive ... |
20-278 | 1.04e-06 | |||||
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive bacteria as part of a type IV pilus system used for DNA binding and uptake when species such as Streptococcus pneumoniae or Bacilus subtilis are in a competent state for natural transformation. Members of this family, typically called ComGB (second protein of the ComG operon), belong more broadly to the family of GspF, part of type 2 secretion systems (T2SS) in Gram-negative bacteria. Pssm-ID: 468941 [Multi-domain] Cd Length: 333 Bit Score: 49.78 E-value: 1.04e-06
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| PTP-MTMR5-like | cd14534 | protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related ... |
208-313 | 1.03e-04 | |||||
protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatases 5 and 13; This subgroup of enzymatically inactive phosphatase domains of myotubularins consists of MTMR5, also known as SET binding factor 1 (SBF1) and MTMR13, also known as SET binding factor 2 (SBF2), and similar domains. Beside the pseudophosphatase domain, they contain a variety of other domains, including a DENN and a PH-like domain. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. MTMR5 and MTMR13 are pseudophosphatases that lack the catalytic cysteine in their catalytic pocket. Mutations in MTMR13 causes Charcot-Marie-Tooth type 4B2, a severe childhood-onset neuromuscular disorder, characterized by demyelination and redundant loops of myelin known as myelin outfoldings, a similar phenotype as mutations in MTMR2. Mutations in the MTMR5 gene cause Charcot-Marie-tooth disease type 4B3. MTMR5 and MTMR13 interact with MTMR2 and stimulate its phosphatase activity. Pssm-ID: 350382 [Multi-domain] Cd Length: 274 Bit Score: 43.51 E-value: 1.03e-04
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| T2SSF | pfam00482 | Type II secretion system (T2SS), protein F; The original family covered both the regions found ... |
24-125 | 3.76e-04 | |||||
Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats). Pssm-ID: 425708 [Multi-domain] Cd Length: 119 Bit Score: 39.63 E-value: 3.76e-04
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| T2SSF | pfam00482 | Type II secretion system (T2SS), protein F; The original family covered both the regions found ... |
221-321 | 4.50e-03 | |||||
Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats). Pssm-ID: 425708 [Multi-domain] Cd Length: 119 Bit Score: 36.54 E-value: 4.50e-03
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| Blast search parameters | ||||
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