|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
1-372 |
1.38e-98 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 297.54 E-value: 1.38e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd17471 5 TLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRG-GDRKPLILLALLAGALGYLLFAFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIFQGLFAPAMPQLYASARESINiSSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTV 160
Cdd:cd17471 84 RNYWVLLLVGVVLLSLGAAAFPQLFALAREYAD-RSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAPnmfKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGY 240
Cdd:cd17471 163 LLYLVVALLVLFLLPSVKPPAQKATPASSLVKAP---VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 241 LASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPD 320
Cdd:cd17471 240 LFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPG 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1812584674 321 FPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIF 372
Cdd:cd17471 320 QPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
3-376 |
5.41e-35 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 132.20 E-value: 5.41e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 3 LLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNvNRKVLIISALFMGAVSFSIYFYVHQ 82
Cdd:TIGR00899 8 LTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQG-DRKGLILFCCLLAALACLLFAWNRN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 83 IWLFIVLYAIFQGLFAPAMPQLYASARESINiSSSRDRAKFAnTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAI 162
Cdd:TIGR00899 87 YFLLLVLGVLLSSFASTANPQLFALAREHAD-RTGREAVMFS-SVMRAQISLAWVIGPPLAFWLALGFGFTVMFLTAALA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 163 LLFTLILQVFFYQNLPVEYQVSSQhhvEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLA 242
Cdd:TIGR00899 165 FVLCGVLVWLFLPSYPRGAPGALT---RLEVRGLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDKLAGLMM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 243 SLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPDFP 322
Cdd:TIGR00899 242 GTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQDLMPGRA 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1812584674 323 GYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTKD 376
Cdd:TIGR00899 322 GAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-375 |
1.13e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 114.98 E-value: 1.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFAtKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDThnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR--FGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIFQGLFAPAMPQLYASAresINISSSRDRAKfANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTV 160
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALI---ADIAPPEERGR-AMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQ--NLPVEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYV 238
Cdd:cd17325 158 ALALLALVLALLLLPepRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 239 GYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDIL 318
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1812584674 319 PDFP-GYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTK 375
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
3-376 |
7.48e-28 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 113.04 E-value: 7.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 3 LLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNvNRKVLIISALFMGAVSFSIYFYVHQ 82
Cdd:PRK15011 26 LTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRG-DRKSLIVFCCLLGVLACTLFAWNRN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 83 IWLFIVLYAIFQGLFAPAMPQLYASARESINiSSSRDRAKFAnTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAI 162
Cdd:PRK15011 105 YFVLLFVGVFLSSFGSTANPQMFALAREHAD-KTGREAVMFS-SFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 163 LLFTLILQVFFYQNLPVEYQVSSQhhvEKSAPNMFKDKALFIpFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLA 242
Cdd:PRK15011 183 FIVCGVMVWLFLPSMRKELPLATG---TLEAPRRNRRDTLLL-FVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMM 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 243 SLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPDFP 322
Cdd:PRK15011 259 GTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIGILGGIGMLYFQDLMPGQA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1812584674 323 GYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTKD 376
Cdd:PRK15011 339 GSATTLYTNTSRVGWIIAGSLAGIVAEIWNYHAVFWFALVMIIATLFCLLRIKD 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-337 |
2.73e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.89 E-value: 2.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFAtKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDThnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:COG2814 19 AFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR--FGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIFQGLFAPAMPQLYASAREsinISSSRDRAKfANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTV 160
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPAALALIAD---LVPPERRGR-ALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFyqnLPvEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGY 240
Cdd:COG2814 172 VLALLALLLLLRL---LP-ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 241 LASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPD 320
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330
....*....|....*...
gi 1812584674 321 -FPGYASTLFANAMVIGQ 337
Cdd:COG2814 328 eARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
1-370 |
3.35e-21 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 93.83 E-value: 3.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDthNVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd17329 8 SFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD--RFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYA---IFQGLFAPAMPQLYASAresinisSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELnGYSGLFG 157
Cdd:cd17329 86 HSPWLFAIALVltgFGGGLFEPASEAMIADV-------TTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 158 GTVAILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAPNMFKDKALFIPFIAFIL--LHIGQWMYTMnmPLFVTNYLRERD 235
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLisLIYFQLESTL--PVYVVEILGLGE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 236 SYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQ 315
Cdd:cd17329 236 SLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1812584674 316 DILPDfPGYASTLFANAMV--IGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMIL 370
Cdd:cd17329 316 ALAPP-DKRGSYMGFYALAwgLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
1-378 |
1.87e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.23 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALA----AVSQFVVNSIIARFSDthnvnRKVLIISALFMGAVSFSI 76
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPvlvgALLRIPLGFLVDRFGP-----RRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 77 YFyVHQIWLFIVlYAIFQGLFAPAMpqlYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLF 156
Cdd:COG2223 88 AL-AVSYWLLLL-LGLLLGIGGGGS---FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 157 GGTVAILLFTLILQVFFYQNLPVEYQVSSQHHVeKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDS 236
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 237 YVGYLASLCAGLEVPFMVILGILSAKF-PTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQ 315
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1812584674 316 DILP-DFPGYASTLFANAMVIGQLCGNLLGGVMSHWVG-LENVFFVSATSILIGMILIFFTKDQK 378
Cdd:COG2223 322 DIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-375 |
1.22e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.51 E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPyLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDThnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:COG0738 17 FFLWGFATALWGP-LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDR--FGYKRGLLLGLLLMALGLLLFALA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIV---LYAIFQGLFAPAMpQLYASAREsinisssRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFG 157
Cdd:COG0738 94 PSYPLLLLalfLLGLGLGLLDVAA-NPYVAALG-------PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 158 GTVAILLFTLILQVFFY-QNLP-VEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERD 235
Cdd:COG0738 166 PYLILAVLLLLLALLFLrSKLPeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 236 SYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQ 315
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 316 DILPDFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTK 375
Cdd:COG0738 326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-372 |
1.90e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.00 E-value: 1.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFAtKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDThnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd06174 5 FFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADR--FGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIFQGLFAPAMPQLYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTV 160
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAP--NMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYV 238
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLlkRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 239 GYLASLCAGLEVPFMVILGILSAK-FPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDI 317
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1812584674 318 LPDFP-GYASTLFANAMVIGQLCGNLLGGVM-SHWVGLENVFFVSATSILIGMILIF 372
Cdd:cd06174 322 FPPEIrGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-372 |
2.50e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.74 E-value: 2.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 21 KDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDthNVNRKVLIISALFMGAVSFSIYFYVHQIWLFIVLyAIFQGLFAPA 100
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSD--RIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 101 MPQLYASAreSINISSSRDRAKFANTVLrSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAILLFTLILQVFFYQNLPVE 180
Cdd:cd17324 104 FWAIAAAY--AADLVPPEKRGRAIGLVF-SGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 181 YQVSSQHHVEKSApnMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLASLCAGLEVPFMVILGILS 260
Cdd:cd17324 181 KPGSLGLLSSLLL--LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 261 AKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPDFPGYASTLFANAMVIGQLCG 340
Cdd:cd17324 259 DRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALG 338
|
330 340 350
....*....|....*....|....*....|..
gi 1812584674 341 NLLGGVMSHWVGLENVFFVSATSILIGMILIF 372
Cdd:cd17324 339 AALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-375 |
2.87e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.78 E-value: 2.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 2 MLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNV----NRKVLIISALFMGAVSFSIY 77
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrRRPWILIGAIPLALSFVLLF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 78 F-----YVHQIWLFIVLYAIFQGLFAPAMPQLYASARESIniSSSRDRAKfANTVLRSMFSLGFLFGPFIGSQLIEL--- 149
Cdd:COG2211 100 TapdlsPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT--PDYEERTR-LSSWRFAFAGLGGLLASVLPPPLVAAfgg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 150 NGYSGLFGGTVAILLFTLILQVFFYQNLPVEYQVSSQHH-VEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVT 228
Cdd:COG2211 177 DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVsLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 229 NYLRERDSYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFK--NFYMMLAGQVFLAIFLAIL 306
Cdd:COG2211 257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAI 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 307 LGLGISYFQDILP--------DFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLE---------------NVFFVSATS 363
Cdd:COG2211 337 LVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgirlLFFLLPAVL 416
|
410
....*....|..
gi 1812584674 364 ILIGMILIFFTK 375
Cdd:COG2211 417 LLLAALLLLFYP 428
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-319 |
8.67e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 71.68 E-value: 8.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHnvNRKVLIISALFMGAVSFSIYFYV 80
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLyAIFQGLFAPAMpqlYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFgGTV 160
Cdd:pfam07690 83 SSLWLLLVL-RVLQGLGAGAL---FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF-LIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAPNMFKD---KALFIPFIAFILLHIGQWMYTMNMPLFVTnYLRERDSY 237
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAllrDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 238 VGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLF---GGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYF 314
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLlilAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
....*
gi 1812584674 315 QDILP 319
Cdd:pfam07690 317 SDLAP 321
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
1-374 |
3.36e-13 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 70.37 E-value: 3.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIA----RFSDTHNvnRKVLIISALFMGAVSFSI 76
Cdd:cd17391 5 NFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSpiwgRLADRYG--RKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 77 YFYVHQIWLFIVLyAIFQGLFAPAMPqlyaSARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLF 156
Cdd:cd17391 83 MAFVTNVWQLLIL-RLLQGVFSGYVP----NATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 157 GGTVAILLFTLILQVFFYQN--LPVEYQVSSQ-HHVEKSAPNmfkDKALFIPFIAFILLHIGQWMYTMNMPLFVtNYLRE 233
Cdd:cd17391 158 FITGGLLFLAFLLTLFFVKEdfKPVEKKKMVStKEVWNSVPN---PSLLISLFVTTFIIQLANQSIEPILTLYI-RQLMG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 234 RDSYVGYLASLCAG-------LEVPFmviLGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAIL 306
Cdd:cd17391 234 DASNLAFISGLVFSatgvsslLSAPR---LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGL 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1812584674 307 LGLGISYFQDILPDfpGYASTLFA---NAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFT 374
Cdd:cd17391 311 LPAINSLLAKITPK--EVAGRIFGynqSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
7-373 |
4.47e-13 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 69.92 E-value: 4.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 7 GIAVTVPYLVLFAtKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVNRKVLIISALFMGAVSFSIYFYVHQIWLF 86
Cdd:cd17335 12 ALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 87 IVLYAIFQGLFAPAMPQLyasarESINISSSRDRAKFANTVlRSMFSLGFLFGPFIGSQLIE----LNGYSGLFGGTVAI 162
Cdd:cd17335 91 LLLVILGAFFSAPVVPLV-----DSITLQYLGEERERYGKQ-RLWGSIGFGIAALLVGILIDrsstYKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 163 LLFTLILQVFFyqnlPVEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTmnmpLFVTNYLRE---RDSYVG 239
Cdd:cd17335 165 MLLALLLALKF----PFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIY----SFLFWHLQDlggSKTLIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 240 YLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILP 319
Cdd:cd17335 237 LLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1812584674 320 dfPGYAST----LFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:cd17335 317 --PGLRATaqglLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
1-375 |
2.74e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.23 E-value: 2.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFAtKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDThnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIV---LYAIFQGLFAPAMPQLYASaresINISSSRDRAKFANTVlrsMFSLGFLFGPFIGSQLIELNGYSGLFG 157
Cdd:cd17489 82 TSVALLLVlrlIHGIGWGAFTTAAATLVAD----IIPPSRRGEGIGYYGL---ATTLAMALGPALGLFLYQHLGFAVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 158 GTVAILLFTLILQVFFYQNLPVeyqVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLfvtnYLRERDSY 237
Cdd:cd17489 155 VAAVLALLALLLVFLVKDPPPV---AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPL----YAAERGIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 238 VGYLASLCAGLEVPFM-VILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAI-FLAILLGLGISYFQ 315
Cdd:cd17489 228 NAGLFFTVYAIALLLSrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAVD 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 316 DILPDFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTK 375
Cdd:cd17489 308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-373 |
4.22e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.87 E-value: 4.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 10 VTVPYLVLFATKDLGMTttqyGLLLALAAVSQFVVNSIIARFSDTHNVnRKVLIISALFMGAVSFSI----YFYVHQIWL 85
Cdd:cd06173 20 VALPWLVLQLTGSALLV----GLVLAAFFLPFLLFSPFAGVLADRFDR-RRLLILADLLRALLAAVLallaLLGSLSLWL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 86 FIVLYAIFQGLFAPAMPQLYASARESInissSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAILLF 165
Cdd:cd06173 95 LLVLAFLLGIASAFFGPARQALLPELV----PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 166 TLILQVFFYQNLPVEYQVSSQHHVEKSAPNMF---KDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLA 242
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREGLRylrRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 243 SLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPD-F 321
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDeL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1812584674 322 PGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-373 |
4.37e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.82 E-value: 4.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 10 VTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVnRKVLIISALFMGAVSFSIYFyVHQIWLFIVL 89
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGR-RRVLAIGLLLWGLATLLFGF-ATSFWQLLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 90 YA---IFQGLFAPAMPQLyasaresINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAILLFT 166
Cdd:COG2271 105 RFllgLGEAGFFPAALKL-------IAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 167 LILQVFFYqnlpveyqvssqhhveksapnmfkdkalfipFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLASLCA 246
Cdd:COG2271 178 ALLRFWLL-------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 247 GLEVPFMVILGILSAKF--PTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILP-DFPG 323
Cdd:COG2271 227 LAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARG 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1812584674 324 YASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
206-378 |
5.12e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.04 E-value: 5.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 206 FIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGV 285
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 286 FKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPD-FPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSI 364
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170
....*....|....
gi 1812584674 365 LIGMILIFFTKDQK 378
Cdd:pfam07690 162 LLAAVLLLLPRPPP 175
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
3-373 |
8.29e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 56.43 E-value: 8.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 3 LLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHnvNRKVLIISALFMGAVSFSIYFYVHQ 82
Cdd:cd17330 9 ALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRY--GRKPVLLLSLAGSAVSYVLLGLSRN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 83 IWLFIV---LYAIFQGLFAPAmpQLYASAresinISSSRDRAKfANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGT 159
Cdd:cd17330 87 LWLLFLarfLDGLTGGNVSVA--QAYIAD-----ITDEEERAK-AFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 160 VAILLFTLILQVFFYqnlpveyqvssqhhveksapnmfkdKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVG 239
Cdd:cd17330 159 AALALLNLVLVLFFL-------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 240 YLASLC-AGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDIL 318
Cdd:cd17330 214 LLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSV 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 319 PDFP-----GYASTLFANAMVIGQLCGNLLGGVMSHWVglenVFFVSATSILIGMILIFF 373
Cdd:cd17330 294 PSKEqgkaqGIIQSLQSLARIIGPLLAGPLYSFLGPGV----PFLLAAGLLLIALFLLSL 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
192-374 |
5.32e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 5.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 192 SAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNyLRERDSYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLF 271
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 272 GSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILP-DFPGYASTLFANAMVIGQLCGNLLGGVMSHW 350
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....
gi 1812584674 351 VGLENVFFVSATSILIGMILIFFT 374
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
12-372 |
2.07e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 12 VPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVNRKV---LIISALFMGAVSFSIYFYVhqIWLFIV 88
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLplgPLLTGLGLSLLGFAPNYWL--LLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 89 LYAIFQGLFAPAMPQLYASAresinissSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNgysGLFGGTVAILLFTLI 168
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQA--------AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF---GGLGLLILLIIPGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 169 LQVFFYQNLPVEYQVssQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRER---DSYVGYLASLC 245
Cdd:cd17478 162 VALLLLRLRPLKKPE--AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRgysLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 246 AGLEVPFMVILGILSAKFPTRTLLLFgSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPDFPGYA 325
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIIA-SLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1812584674 326 STL-FANAMVIGQLCGNLLGGVMSHWvGLENVFFVSATSILIGMILIF 372
Cdd:cd17478 319 SGLmMGLSFGLGGIGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-173 |
1.26e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 2 MLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVNRKVLIISALFMGAVSFSIYFYVH 81
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 82 QIWLFIVLYAIFQGLFAPAMPQLYASARESInissSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVA 161
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELF----PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
170
....*....|..
gi 1812584674 162 ILLFTLILQVFF 173
Cdd:COG2271 346 LALLAALLALLL 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
3-374 |
1.68e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 3 LLGMGIAVTVPYLVLFAtKDLGMTTTQYGLLLAL----AAVSQFVVNSIIARFSdthnvNRKVLIISALFMGAVSFSIYF 78
Cdd:cd17474 10 LAVLGVSIVDPILPAIA-EALGASPAQVGLLITAftlpAAVLMPVAGVLADRFG-----RKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 79 yVHQIWLFIVLYAIfQGLFAPAMPQLYASAreSINISSSRDRAKfANTVLRSMFSLGFLFGPFIGSqLIELNGYSGLFGG 158
Cdd:cd17474 84 -SDSFALLLAGRAL-QGIGAAGLGPLALTL--IGDLFEGGERAK-AMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 159 TvAILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYV 238
Cdd:cd17474 158 L-AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 239 GYLASLCAGLEVPFMVILG-ILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAgqvfLAIFLAILLGLGISYFQDI 317
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLI----AIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1812584674 318 L-----PDFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFT 374
Cdd:cd17474 313 VtelapEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
236-374 |
3.57e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 48.70 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 236 SYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQ 315
Cdd:cd17324 34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 316 DILP-DFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFT 374
Cdd:cd17324 114 DLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
1-169 |
8.16e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 8.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVNRKVLIisALFMGAVSFSIYFYV 80
Cdd:cd06173 217 LALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI--GALLLGLALLVLGLS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIFQGLFAPAMPQLYASARESInisSSRDRAKfANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTV 160
Cdd:cd06173 295 PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV---PDELRGR-VFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAG 370
|
....*....
gi 1812584674 161 AILLFTLIL 169
Cdd:cd06173 371 ALLLLAALL 379
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
59-373 |
2.41e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 59 RKVLIISALFMGAVSFSIYFYVHQIWLFIVLYAIF---QGLFAPAMPQLYASARESinisssrdRAKFANTVLRSMFSLG 135
Cdd:cd17333 60 RRRTLILGLLLISLALALIFATPSIYLFVVLMFLAglgAGILDTGANTFVGALFEE--------SSATRLNVLHGFFGLG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 136 FLFGPFIGSQLIELN---GYSGLFGGTVAILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILL 212
Cdd:cd17333 132 ALIGPLIATSLLTSElswSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLY 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 213 HIGQWMYTMNMPLFVTNYLRERDSYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMM 292
Cdd:cd17333 212 VGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 293 LAGQVFLAIFLAILLGLGISYFQDILPDFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIF 372
Cdd:cd17333 292 LVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
.
gi 1812584674 373 F 373
Cdd:cd17333 372 L 372
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
6-372 |
2.87e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.61 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 6 MGIAVTVPYLVLfatkdLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNvNRKVLIISALFMGAVS---FSIYFYVHQ 82
Cdd:cd17370 17 MARSILPLFLVV-----LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTG-KRKPLVILGYGLSALAkplLALAGSWQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 83 IWLFIVLYAIFQGLFAPAMPQLYASARESinisSSRDRAkFAntVLRSMFSLGFLFGPFIGSQLIEL--NGYSGLFGGTV 160
Cdd:cd17370 91 VLLLRILERLGKGIRTPPRDALLADATPP----SGRGKA-FG--LHRALDTLGAVLGPLLAALLLYLlgGNYRTIFLLAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQN--LPVEYQVSSQHHVEKSAPNMFKdKALFIPFI--------AFILLHIGQ-WMYTMNMPLFvtn 229
Cdd:cd17370 164 IPALLALLILLFVVKEypRPPKLRKKSKKTSLKKLPKAFW-LYLLAVALfalgnfsfAFLILRAQElGLSAALIPLL--- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 230 ylrerdsYVGYLaslcaGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGL 309
Cdd:cd17370 240 -------YALFN-----LVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESI 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812584674 310 GISYFQDILPDFP-GYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIF 372
Cdd:cd17370 308 ERAAVADLVPAELrGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
256-378 |
3.98e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 256 LGILSAKFPTRTLLLF-GSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLA---ILLGLGISYFQdilPDFPGYASTLFAN 331
Cdd:cd17490 51 LGILSDRIGKRKLFIIiGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAtwvSFTVLYASYFP---PDEAAKAMGLINL 127
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1812584674 332 AMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTKDQK 378
Cdd:cd17490 128 VNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEER 174
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
1-174 |
4.26e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 4.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFsdTHNVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd17329 209 SFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARL--VERFRLRKILMIGILLFAIGFAVLAFA 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIF---QGLFAPAMPQLYAsaresiNISSSRDRAKFaNTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFG 157
Cdd:cd17329 287 NTLAVLILAMIVLtlgEMLVFPAVQTLVA------ALAPPDKRGSY-MGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
170
....*....|....*..
gi 1812584674 158 GTVAILLFTLILQVFFY 174
Cdd:cd17329 360 ILAALGLIAAALLLGLQ 376
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-152 |
5.26e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 5.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNvNRKVLIISALFMGAVSFSIYFYV 80
Cdd:COG2211 237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG-KKKAFIIGLLLAALGLLLLFFLG 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1812584674 81 HQ----IWLFIVLYAIFQGLFAPAMPQLYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGY 152
Cdd:COG2211 316 PGnlwlLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
2-169 |
1.05e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 2 MLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHnvNRKVLIISALFMGAVSFSIYFYVH 81
Cdd:cd17324 208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG--GRRALLIALLLLAAALLLLTLLGP 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 82 QIWLFIVLyAIFQGLFAPAMPqlyaSARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVA 161
Cdd:cd17324 286 SPLLLLVG-LVLWGLGFFAAH----SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAA 360
|
....*...
gi 1812584674 162 ILLFTLIL 169
Cdd:cd17324 361 LLLLALLL 368
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
127-373 |
1.12e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 43.75 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 127 VLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAILLFTLILQVFFyqnLPVEYQVSSQHHVeksapNMFkdKALFIPF 206
Cdd:cd17385 133 TLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFI---LPRYDDDPSPKSG-----SML--KLLKIPS 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 207 IAFILLHIgqwmYTMNMPL-----FVTNYLRERD---SYVGYLASLCAGLEVPFMVILGILSAKFP-TRTLLLFGSLFGG 277
Cdd:cd17385 203 VLLLCLSI----VSGSVSLgfldpTLSPHLRQFKlspGQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITG 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 278 AFYFSIGVFKNFYmmLAGQVFLAIFLAILLGLGISY-----FQDILPD-----FP------GYASTLFANAMVIGQLCGN 341
Cdd:cd17385 279 VGFLLLGPAPLLP--IKSELWMVIIGLVLLGLSLGAalvptFPELLNCareygFPdnlstyGLVSGLFNAAFSLGAFIGP 356
|
250 260 270
....*....|....*....|....*....|...
gi 1812584674 342 LLGGVMSHWVGLEN-VFFVSATSILIGMILIFF 373
Cdd:cd17385 357 TLGGFLLERLGFEWaATIQAGLAFVVGILMSIY 389
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-371 |
1.16e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 4 LGMGIAVT-VPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVNRkvLIISALFMGAVSFSIYFYVHQ 82
Cdd:COG2807 28 LNLRPAITsVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER--TLLLALLLLAAGLLLRSLAPS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 83 IWLFIVLYAIF---QGLFAPAMPQLyasaresinISSS-RDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGG 158
Cdd:COG2807 106 VALLLAGTALIgagIAVGNVLLPGL---------IKRWfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 159 TVAILLFTLILQVFFYQNLPVEYQVSSQHHvekSAPNMFKDKaLFIPFIAFILLHIGQWmYTMNMplFVTNYLRER---D 235
Cdd:COG2807 177 WALLALLALLLWLPLLRRRPAAAAAAPAAA---SLRSLWRSP-LAWLLTLFFGLQSLLY-YAVVA--WLPPILRDAglsA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 236 SYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAfyfsIGVFknfyMMLAGQVFLAIFLAILLGLG----- 310
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL----AGLL----GLLLAPGSLPWLWAVLLGLGqgglf 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1812584674 311 ---ISYFQDILPDfPGYASTLFANAMVIGQL---CGNLLGGVMSHWVGLENVFFVSATSILIGMILI 371
Cdd:COG2807 322 plaLTLIGLRART-PAEAAALSGMAQSVGYLlaaLGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-281 |
1.73e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.88 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFAtKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNvNRKVLIISALFMGAVSFSIYFyV 80
Cdd:COG0477 23 TFLEGLDFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYG-RKRVLLIGLLLFGLASLLCGL-A 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIfQGLFAPAMpqlYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTV 160
Cdd:COG0477 100 PSPELLIAARAL-QGIGAGGL---MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQNLPVEYQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERdSYVGY 240
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA-LLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1812584674 241 LASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYF 281
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-373 |
3.94e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 10 VTVPYLVLFATKDLGMTTTQYGLLLAL----AAVSQFVVNSIIARFSdthnvNRKVLIISALFMGAVSFSIYFyVHQIWL 85
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAfflgYALFQVPGGWLLDRFG-----ARKVLAVSMLLWSLFTALTGF-ATSLTS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 86 FIVLYAIFqGLF-APAMPqlyASARESINISSSRDRAkFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFggtVAILL 164
Cdd:cd17319 94 LYVLRFLL-GVAeAGFFP---GAIKALAEWFPARERG-RATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF---IIEGL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 165 FTLILQVFFYQNLPVEYQVssqhhveksapnmfkdkalfipFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLASL 244
Cdd:cd17319 166 LGLLLAVLWWFYLRQVWGL----------------------ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 245 CAGLEVPFMVILGILSAKFPT---RTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILPdf 321
Cdd:cd17319 224 PFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP-- 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1812584674 322 PGYASTLFANAMVIGQLCG----NLLGGVMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:cd17319 302 GEAAATAGGLINSGGNLGGfvapLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
6-375 |
5.06e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 5.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 6 MGIAVTVPYLVLFATKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDthNVNRKVLIISALFMGAVSFSIYFYVHQIWL 85
Cdd:cd17472 10 LGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSD--RIGRKPVILFGLLLFIAGSLLAAYATSIYG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 86 FIVLYAIfQGLFAPAMPqLYASARESINiSSSRDRA-KFANTVLRSMFSLGFLFGPFIGSQLielnGYSGLFGGTVAILL 164
Cdd:cd17472 88 LILGRAL-QGSGAISSV-VMALLADLTR-EENRTKAmALIGASIGIAFAISMVLGPLLAAHL----GVSGLFLITAILSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 165 FTLILQVFFYQNLPVEYQVSsqHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDS-YVGYLAS 243
Cdd:cd17472 161 VSLLILLFFVPDPPKIVQIS--EKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQlWKVYLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 244 LCAGLEVpfMVILGILSAKFPTRTLLLFGS--LFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILP-D 320
Cdd:cd17472 239 ILIGFIL--MVPFVIYAEKKGKMKQVFVSSilLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPkE 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1812584674 321 FPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTK 375
Cdd:cd17472 317 YRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
1-173 |
6.77e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.42 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFaTKDLGMTTTQYGLLLALAAVSQ----FVVNSIIARFSdthnvNRKVLIISaLFMGAVSFSI 76
Cdd:cd17335 207 AFLMGFGHGLIYSFLFWH-LQDLGGSKTLIGLLWTVGVVSEipffFFSSRLIQRFG-----HVGLLYLG-LLAYVVRWLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 77 YFYVHQIWLFIVLyAIFQGLFAPAMpqlYASARESINISSSRDRAKFANTVLRSM-FSLGFLFGPFIGSQLIELNGYSGL 155
Cdd:cd17335 280 YSFLENPWLVLPI-ELLHGLTFALV---WAAAVSYASAAAPPGLRATAQGLLQGLyFGLGGGLGSLIGGYLYEAFGARTT 355
|
170
....*....|....*...
gi 1812584674 156 FGGTVAILLFTLILQVFF 173
Cdd:cd17335 356 FRFFAIAALAGLLAFFLI 373
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
255-378 |
7.84e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.04 E-value: 7.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 255 ILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILP-DFPGYASTLFANAM 333
Cdd:cd17489 50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPpSRRGEGIGYYGLAT 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1812584674 334 VIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFFTKDQK 378
Cdd:cd17489 130 TLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPP 174
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
235-373 |
1.64e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 235 DSYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYF 314
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1812584674 315 QDILPD-FPGYASTLFANAMVIGQLCGNLLGG--VMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:cd06174 110 ADLFPErERGRALGLLQAFGSVGGILGPLLGGilASSLGFGWRAVFLIAAALALLAAILLLL 171
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
22-373 |
1.78e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 22 DLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVN---RKVLIISALFMGAVSFSIYFYVHQI---------WLFIVL 89
Cdd:cd17313 28 TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRigrRRPFILVGAPLAALGLILIPNAADIglalgdgprTWALVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 90 YAIFQGLFAPAMPQLYASARESI-NISSSRDRAKfANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVA------- 161
Cdd:cd17313 108 FVLGIVLLDFAMNVCQGPVRALLpDLVPPEQRSK-ANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKvpfyiga 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 162 -ILLFTLILQVFFYQNLPVEYqVSSQHHVEKSAPNMFKD--KALFIPFIAFILLHIGQ---WMYTMNMPLFVTNYLRERD 235
Cdd:cd17313 187 iILLVCVLVTLFFVKEPPLSP-EAGEHSENPSLGEVLKSllKLLKIMPRSLLRLLLVIffwWIAFFPFELFFTDYMGEEV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 236 SYVGYLASLCAGLEVP---------------FMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLA 300
Cdd:cd17313 266 YHGTSAASSHYGAGVRmgawgllifslafliFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGG 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1812584674 301 IFLAILLGLGISYFQDILPDFPGYAST---LFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:cd17313 346 IGWATININPYPLVSDYHSESGRGQGTdtgLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
1-371 |
3.35e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATkDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDThnVNRKVLIISALFMGAVSFSIYFYV 80
Cdd:cd17477 5 VALLGLGSGLLLPLLSLRLE-REGVSTALIGLVASAYYLGILLGSPLVPRLIRR--VGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 81 HQIWLFIVLYAIFqGLfapAMPQLYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSqLIELNGYSgLFGGTV 160
Cdd:cd17477 82 DSPWVWFLLRFVM-GI---GLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGAL-PFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 161 AILLFTLILQVFFYQNLPVEYQVSSQHHVE--KSAPnmfkdKALFIPFIAFILLHIgqwMYTMnMPLFVTNyLRERDSYV 238
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRllRIAP-----LALLGAFVAGFLEGA---FYSL-LPLYGLR-LGLSVAQA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 239 GYLASLCAGLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLAGQVFLA-IFLAILLGLGISYFQDI 317
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWgGAAGPLYTLALALAGDR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1812584674 318 LP--DFPGyASTLFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILI 371
Cdd:cd17477 306 LPgdELVA-ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
1-310 |
4.06e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 1 MMLLGMGIAVTVPYLVLFATKDLGMTTTQYGLLLALA----AVSQFVVNSIIARFSDthnvnRKVLIISALfMGAVSFSI 76
Cdd:cd17355 11 ILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGllafGLAQPFVGRLLDRFGP-----RRVMLLGLL-LLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 77 YFYVHQIWLFIVLYAIFQGLFAPAmpqLYASARESINISSSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLF 156
Cdd:cd17355 85 LALATSLWQLYLLWGLLGGGGAGT---LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 157 GGTVAILLFTLILQVFFYQNLPVE-----YQVSSQHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYL 231
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADlalraYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1812584674 232 RERdSYVGYLASLCAGLEVPFMVILGILSAKFPTRTLLLfgslfggAFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLG 310
Cdd:cd17355 242 ISP-AAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLA-------ASYALRALGLALLLLLPFPPLALLLFAALFGLG 312
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-373 |
4.51e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 4.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 20 TKDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNVnRKVLIISALFMGAvSFSIYFYVHQIWLFIVLYAIFQGLFAP 99
Cdd:cd17353 30 SSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGP-RKAILIGGILFGL-GFILSAFAISLPLLFLGYGVLGGIGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 100 AMpqlYASAresinISSSR----DRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLFGGTVAILLFTLILQVFFYQ 175
Cdd:cd17353 108 IG---YITP-----VSTAVkwfpDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 176 NLPVEYQVSS---------QHHVEKSAPNMFKDKALFIPFIAFILLHIGQWMYTMNMPLFVTNYLRERDSYVGYLASLCA 246
Cdd:cd17353 180 DPPKGWVPPGvdplannaeNSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 247 GLEVPFMVILGILSAKFPTRTLLLFGSLFGGAFYFSIGVFKNFYMMLagqVFLAIFLAILLGLGISYFQDILPDFPG--Y 324
Cdd:cd17353 260 IFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLF---VLGVALIGFCYGGGFALFPALTADFFGtkN 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1812584674 325 AST---LFANAMVIGQLCGNLLGGVMSHWVGLENVFFVSATSILIGMILIFF 373
Cdd:cd17353 337 AGTnygLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-347 |
7.23e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 7.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 21 KDLGMTTTQYGLLLALAAVSQFVVNSIIARFSDTHNvNRKVLIISALFMGAVSFsIYFYVHQIWLFIVLYAIfQGLFAPA 100
Cdd:cd17504 24 REFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYG-RKKVLLIVLAIYTAGSL-LAAFAPNLPVLIAGRAL-QGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 101 MPQLYASARESInissSRDRAKFANTVLRSMFSLGFLFGPFIGSQLIELNGYSGLF--GGTVAILLFTLILQVffyqnlp 178
Cdd:cd17504 101 FPLAFALVREEF----PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFwtAAPVAVLLAALVPLI------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 179 veyqvssqhhveksAPNMFKDKALFIPFIAFILLHIGQWMytmnMPLFVTNYLRERDSYVGYLASLCAGL-EVPFMVIL- 256
Cdd:cd17504 170 --------------DLRLLRRRNVLLANITALLAGFGMFM----VFQLLPQLLQLPTPTGFGLGITEAGLlLLPGALVMl 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 257 ------GILSAKFPTRTLLLFGSLFGGAFYFSIGVF-KNFYMMLAGQVFLAIFLAILL-GLGISYFQDILPDFPGYASTL 328
Cdd:cd17504 232 iagplaGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFaSLPNIVVESVPPDRTGIATGM 311
|
330
....*....|....*....
gi 1812584674 329 FANAMVIGQLCGNLLGGVM 347
Cdd:cd17504 312 NTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
206-375 |
7.42e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 37.98 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 206 FIAFILLHIGQWMYTMNMPLFVTnylrERDSYVGYLASLCAGLEVPFMV---ILGILSAKFPTRTLLLF-----GSLFGG 277
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVL----QLTGSALLVGLVLAAFFLPFLLfspFAGVLADRFDRRRLLILadllrALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 278 AFYFSIGVFKNFYMMLAGQVFLAIFLAILLGLGISYFQDILP-DFPGYASTLFANAMVIGQLCGNLLGGVMSHWVGLENV 356
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPkEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170
....*....|....*....
gi 1812584674 357 FFVSATSILIGMILIFFTK 375
Cdd:cd06173 161 FAINALSFLLSALLLLFIR 179
|
|
| PRK11128 |
PRK11128 |
3-phenylpropionate MFS transporter; |
21-102 |
9.05e-03 |
|
3-phenylpropionate MFS transporter;
Pssm-ID: 236856 [Multi-domain] Cd Length: 382 Bit Score: 37.96 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812584674 21 KDLGMTTTQYGLLLALAAVSQFVVNSIIArfSDTHNVN------RKVLIISALFMGAVSFSiyfyVHQIWLFIVLYAIFQ 94
Cdd:PRK11128 32 KGQGYTPETIGLLLGAGLVARFLGSLLIA--PRVKDPSqlipalRLLALLTLLFAVAFWFG----AHSFWLLFVAIGLFN 105
|
....*...
gi 1812584674 95 GLFAPAMP 102
Cdd:PRK11128 106 LFFSPLVP 113
|
|
| |
