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Conserved domains on  [gi|1805991042|ref|WP_162183367|]
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methyl-accepting chemotaxis protein [Aeromonas caviae]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
141-657 1.14e-73

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 246.86  E-value: 1.14e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 141 LARMRNELLHLDDNYRSAADLLVRYTAGRRSLQNKAELITSGIARDLKLILRADGNTDLVALQGVLAKDIDIANQRLERI 220
Cdd:COG0840    17 LALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 221 VVPDDVKARFTRHVARIPQLVFGDKGLIATLMRRQQISQQLHGLREQQEAQSQQLGEVLDRLIAISNQSMQEDRLSADVA 300
Cdd:COG0840    97 ALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 301 VDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLM 380
Cdd:COG0840   177 AALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 381 EVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSDHVRREVGEANDESRRGRHLMQANR 460
Cdd:COG0840   257 QVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAV 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 461 DGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGAT 540
Cdd:COG0840   337 EGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEAT 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 541 QEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAI 620
Cdd:COG0840   417 KEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQI 496

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1805991042 621 ADVAHETEQASRVSASSGEVLSGLASQQQSLVARFKV 657
Cdd:COG0840   497 AAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
141-657 1.14e-73

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 246.86  E-value: 1.14e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 141 LARMRNELLHLDDNYRSAADLLVRYTAGRRSLQNKAELITSGIARDLKLILRADGNTDLVALQGVLAKDIDIANQRLERI 220
Cdd:COG0840    17 LALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 221 VVPDDVKARFTRHVARIPQLVFGDKGLIATLMRRQQISQQLHGLREQQEAQSQQLGEVLDRLIAISNQSMQEDRLSADVA 300
Cdd:COG0840    97 ALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 301 VDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLM 380
Cdd:COG0840   177 AALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 381 EVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSDHVRREVGEANDESRRGRHLMQANR 460
Cdd:COG0840   257 QVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAV 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 461 DGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGAT 540
Cdd:COG0840   337 EGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEAT 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 541 QEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAI 620
Cdd:COG0840   417 KEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQI 496

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1805991042 621 ADVAHETEQASRVSASSGEVLSGLASQQQSLVARFKV 657
Cdd:COG0840   497 AAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 395-656 2.37e-53

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 184.03  E-value: 2.37e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  395 KTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSDHVRREVGEANDESRRGRHLMQANRDGIEQLATDIAGAM 474
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  475 AITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNLQGCA 554
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  555 RDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIADVAHETEQASRVS 634
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 1805991042  635 ASSGEVLSGLASQQQSLVARFK 656
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 423-621 2.21e-41

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 148.92  E-value: 2.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 423 ELETSATEVARSSDHVRREVGEANDESRRGRHLMQANRDGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTN 502
Cdd:cd11386     2 ELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 503 LLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDVESAL 582
Cdd:cd11386    82 LLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAF 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1805991042 583 AGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIA 621
Cdd:cd11386   162 EEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 268-657 1.46e-35

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 141.68  E-value: 1.46e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 268 QEAQSQQ--LGEVLDRLIAISNQSMQEDRLSADVAVDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMA 345
Cdd:PRK15048  152 QPTQGMQnaMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 346 QGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLMEVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELE 425
Cdd:PRK15048  232 GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLT 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 426 TSATEVARSSDHVRREVGEANDESRRGRHLMqanrDGIEQLATDIAGAmaitrklegySSNIGNILEVIRGMAEQTNLLA 505
Cdd:PRK15048  312 ATVKQNADNARQASQLAQSASDTAQHGGKVV----DGVVKTMHEIADS----------SKKIADIISVIDGIAFQTNILA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 506 LNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNlqGCAR-DVASVMAQSHEQTqqsvqqtrdvesaLAG 584
Cdd:PRK15048  378 LNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIED--SVSRvDTGSVLVESAGET-------------MNN 442

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1805991042 585 IASRMEAIKDIADHMAYAAAEQisvSQGVAQHVAAIADVAHETEQ-ASRV--SASSGEVLSGLASQQQSLVARFKV 657
Cdd:PRK15048  443 IVNAVTRVTDIMGEIASASDEQ---SRGIDQVALAVSEMDRVTQQnASLVqeSAAAAAALEEQASRLTQAVSAFRL 515
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 468-623 4.23e-35

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 130.63  E-value: 4.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 468 TDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMI 547
Cdd:pfam00015  16 KEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALI 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1805991042 548 DNLQGCARDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIADV 623
Cdd:pfam00015  96 IEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQV 171
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
141-657 1.14e-73

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 246.86  E-value: 1.14e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 141 LARMRNELLHLDDNYRSAADLLVRYTAGRRSLQNKAELITSGIARDLKLILRADGNTDLVALQGVLAKDIDIANQRLERI 220
Cdd:COG0840    17 LALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 221 VVPDDVKARFTRHVARIPQLVFGDKGLIATLMRRQQISQQLHGLREQQEAQSQQLGEVLDRLIAISNQSMQEDRLSADVA 300
Cdd:COG0840    97 ALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 301 VDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLM 380
Cdd:COG0840   177 AALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 381 EVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSDHVRREVGEANDESRRGRHLMQANR 460
Cdd:COG0840   257 QVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAV 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 461 DGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGAT 540
Cdd:COG0840   337 EGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEAT 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 541 QEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAI 620
Cdd:COG0840   417 KEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQI 496

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1805991042 621 ADVAHETEQASRVSASSGEVLSGLASQQQSLVARFKV 657
Cdd:COG0840   497 AAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 395-656 2.37e-53

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 184.03  E-value: 2.37e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  395 KTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSDHVRREVGEANDESRRGRHLMQANRDGIEQLATDIAGAM 474
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  475 AITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNLQGCA 554
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  555 RDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIADVAHETEQASRVS 634
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 1805991042  635 ASSGEVLSGLASQQQSLVARFK 656
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 423-621 2.21e-41

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 148.92  E-value: 2.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 423 ELETSATEVARSSDHVRREVGEANDESRRGRHLMQANRDGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTN 502
Cdd:cd11386     2 ELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 503 LLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDVESAL 582
Cdd:cd11386    82 LLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAF 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1805991042 583 AGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIA 621
Cdd:cd11386   162 EEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 268-657 1.46e-35

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 141.68  E-value: 1.46e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 268 QEAQSQQ--LGEVLDRLIAISNQSMQEDRLSADVAVDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMA 345
Cdd:PRK15048  152 QPTQGMQnaMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 346 QGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLMEVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELE 425
Cdd:PRK15048  232 GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLT 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 426 TSATEVARSSDHVRREVGEANDESRRGRHLMqanrDGIEQLATDIAGAmaitrklegySSNIGNILEVIRGMAEQTNLLA 505
Cdd:PRK15048  312 ATVKQNADNARQASQLAQSASDTAQHGGKVV----DGVVKTMHEIADS----------SKKIADIISVIDGIAFQTNILA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 506 LNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNlqGCAR-DVASVMAQSHEQTqqsvqqtrdvesaLAG 584
Cdd:PRK15048  378 LNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIED--SVSRvDTGSVLVESAGET-------------MNN 442

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1805991042 585 IASRMEAIKDIADHMAYAAAEQisvSQGVAQHVAAIADVAHETEQ-ASRV--SASSGEVLSGLASQQQSLVARFKV 657
Cdd:PRK15048  443 IVNAVTRVTDIMGEIASASDEQ---SRGIDQVALAVSEMDRVTQQnASLVqeSAAAAAALEEQASRLTQAVSAFRL 515
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 468-623 4.23e-35

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 130.63  E-value: 4.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 468 TDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMI 547
Cdd:pfam00015  16 KEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALI 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1805991042 548 DNLQGCARDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIADV 623
Cdd:pfam00015  96 IEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQV 171
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
291-657 2.57e-32

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 132.00  E-value: 2.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 291 QEDRLSaDVAVD------SARTWIVMVALCSVLIALIVAW-STARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGE 363
Cdd:PRK15041  173 QNDRLY-DIAVSdnnasySQAMWILVGVMIVVLAVIFAVWfGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQ 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 364 VANSIDQLAHHTKTLLMEVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSDHVRREVG 443
Cdd:PRK15041  252 LAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASHLAL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 444 EANDESRRGRHLMqanrDGIEQLATDIAGAmaitrklegySSNIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFA 523
Cdd:PRK15041  332 SASETAQRGGKVV----DNVVQTMRDISTS----------SQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFA 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 524 VVAEEVRALATRSQGATQEIQVMIDNLQGCArDVASVMAQSHEQTqqsvqqtrdvesaLAGIASRMEAIKDIADHMAYAA 603
Cdd:PRK15041  398 VVAGEVRNLAQRSAQAAREIKSLIEDSVGKV-DVGSTLVESAGET-------------MAEIVSAVTRVTDIMGEIASAS 463

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1805991042 604 AEQisvSQGVAQHVAAIADVAHETEQ-ASRV--SASSGEVLSGLASQQQSLVARFKV 657
Cdd:PRK15041  464 DEQ---SRGIDQVGLAVAEMDRVTQQnAALVeeSAAAAAALEEQASRLTEAVAVFRI 517
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
303-657 5.54e-32

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 130.58  E-value: 5.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 303 SARTWIVMVALCSVLIALIVAWSTaRSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLMEV 382
Cdd:PRK09793  188 SALVFISMIIVAAIYISSALWWTR-KMIVQPLAIIGSHFDSIAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDV 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 383 QTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSateVARSSDHVRrevgEANDESRRGRHLMQANRDG 462
Cdd:PRK09793  267 RKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTAT---VGQNADNAR----QASELAKNAATTAQAGGVQ 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 463 IEQLATDIAGAMAITRKlegyssnIGNILEVIRGMAEQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQE 542
Cdd:PRK09793  340 VSTMTHTMQEIATSSQK-------IGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKE 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 543 IQVMIDnlqgcardvasvmaQSHEQTQQSVQQTRDVESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIAD 622
Cdd:PRK09793  413 IKGLIE--------------ESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQAVSQMDQ 478

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1805991042 623 VAHETEQASRVSASSGEVLSGLASQQQSLVARFKV 657
Cdd:PRK09793  479 VTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
99-654 1.88e-06

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 51.27  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042  99 ALTLDTESERQLARVTDQAPRLFTISEQLMSLHEESVELERVLARMRNELLHLDDNYRSAADLLVRYTAGRRSLQNKAEL 178
Cdd:COG2770     5 LLALLLLLLLLLLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 179 ITSGIARDLKLILRADGNTDLVALQGVLAKDIDIANQRLERIVVPDDVKARFTRHVARIPQLVFGDKGLIATLMRRQQIS 258
Cdd:COG2770    85 VALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 259 QQLHGLREQQEAQSQQLGEVLDRLIAISNQSMQEDRLSADVAVDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRIN 338
Cdd:COG2770   165 ALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 339 RVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHHTKTLLMEVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVA 418
Cdd:COG2770   245 EAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 419 AAIFELETSATEVARSSDHVRREVGEANDESRRGRHLMQANRDGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMA 498
Cdd:COG2770   325 AAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLL 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 499 EQTNLLALNAAIEAARAGEAGRGFAVVAEEVRALATRSQGATQEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDV 578
Cdd:COG2770   405 LELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAAL 484

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1805991042 579 ESALAGIASRMEAIKDIADHMAYAAAEQISVSQGVAQHVAAIADVAHETEQASRVSASSGEVLSGLASQQQSLVAR 654
Cdd:COG2770   485 GALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAA 560
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
293-372 5.36e-05

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 46.16  E-value: 5.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 293 DRL--SADVAVDSA--RT-WIVmVALcSVLIALIVAWSTARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANS 367
Cdd:PRK10549  148 ERLtrNTDINFDKQqrRTsWLI-VAL-STLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQD 225


                  ....*
gi 1805991042 368 IDQLA 372
Cdd:PRK10549  226 FNQLA 230
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 308-372 6.06e-05

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 45.72  E-value: 6.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1805991042 308 IVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLA 372
Cdd:COG5000    11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMT 75
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 197-595 5.26e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 42.95  E-value: 5.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 197 TDLVALQGVLAKDIDIANQRLERIVVPDDVKARFTRHVARIPQLVFGDKGLIATLMRRQQISQQLHGLREQQEAQSQQLG 276
Cdd:COG3850     9 LALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 277 EVLDRLIAISNQSMQEDRLSADVAVDSARTWIVMVALCSVLIALIVAWSTARSIQVPLGRINRVLGLMAQGDMTLRVRYP 356
Cdd:COG3850    89 LLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVS 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 357 ARNELGEVANSIDQLAHHTKTLLMEVQTGSEYLVSETRKTAEIGEQVMSQVQAQKAQTDQVAAAIFELETSATEVARSSD 436
Cdd:COG3850   169 GRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDAL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805991042 437 HVRREVGEANDESRRGRHLMQANRDGIEQLATDIAGAMAITRKLEGYSSNIGNILEVIRGMAEQTNLLALNAAIEAARAG 516
Cdd:COG3850   249 AESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASL 328

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1805991042 517 EAGRGFAVVAEEVRALATRSQGATQEIQVMIDNLQGCARDVASVMAQSHEQTQQSVQQTRDVESALAGIASRMEAIKDI 595
Cdd:COG3850   329 LLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVE 407
HAMP pfam00672
HAMP domain;
327-374 6.70e-03

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 35.29  E-value: 6.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1805991042 327 ARSIQVPLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHH 374
Cdd:pfam00672   3 ARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAER 50
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 333-374 7.54e-03

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 34.73  E-value: 7.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1805991042 333 PLGRINRVLGLMAQGDMTLRVRYPARNELGEVANSIDQLAHH 374
Cdd:cd06225     3 PLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAER 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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