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Conserved domains on  [gi|1783843773|ref|WP_156670056|]
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MULTISPECIES: lysophospholipid acyltransferase family protein [unclassified Mycobacterium]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168420)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006644|GO:0008654
PubMed:  18718904|18931347|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 8-241 4.45e-40

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


:

Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 137.42  E-value: 4.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   8 MKTYFR-SEVHGLGAFPP-GGALVVGNHSGgmFPMDVPIFTVHFyEKFGYDRPVYTLSHDILMTGP-TGEFFRRTGYIRA 84
Cdd:cd07987     1 HRKYFRvYEVRGLENIPDeGPALLVHPHGG--LPIDGALLAAAF-LLLFPGRLPRALADHFLFPLPgLRDLLRRLGAVPG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  85 NRENAAQALRSGGVVIVFPGGDYDAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPAVSIGGQETQLYLSR-----GTWL 159
Cdd:cd07987    78 SRENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 160 AERLGIKRLLRsaiLPLSFGFpfgfsaviPPNLPLPTKivtqvlepidiaaQFGEDPDVDEVDEHVRsvmqQALKDLAAK 239
Cdd:cd07987   158 FRLLPLPRRLP---LYPVFGE--------PIVVPRPPI-------------PDPPDEDVEELHQKYI----AALRELIEK 209


                  ..
gi 1783843773 240 RR 241
Cdd:cd07987   210 HK 211
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 8-241 4.45e-40

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 137.42  E-value: 4.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   8 MKTYFR-SEVHGLGAFPP-GGALVVGNHSGgmFPMDVPIFTVHFyEKFGYDRPVYTLSHDILMTGP-TGEFFRRTGYIRA 84
Cdd:cd07987     1 HRKYFRvYEVRGLENIPDeGPALLVHPHGG--LPIDGALLAAAF-LLLFPGRLPRALADHFLFPLPgLRDLLRRLGAVPG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  85 NRENAAQALRSGGVVIVFPGGDYDAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPAVSIGGQETQLYLSR-----GTWL 159
Cdd:cd07987    78 SRENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 160 AERLGIKRLLRsaiLPLSFGFpfgfsaviPPNLPLPTKivtqvlepidiaaQFGEDPDVDEVDEHVRsvmqQALKDLAAK 239
Cdd:cd07987   158 FRLLPLPRRLP---LYPVFGE--------PIVVPRPPI-------------PDPPDEDVEELHQKYI----AALRELIEK 209


                  ..
gi 1783843773 240 RR 241
Cdd:cd07987   210 HK 211
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 13-142 1.21e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.85  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  13 RSEVHGLGAFPP-GGALVVGNHSGgmfPMDVPIFTVHFYEkfgYDRPVYTLS-HDILMTGPTGEFFRRTGYIRANR---- 86
Cdd:pfam01553   1 RIEVHGLENLPRgGPAIVVANHQS---YLDVLLLSLALYK---RGRPLVFVAkKELFDIPLVGWLMRLLGCIFIDRknrk 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1783843773  87 ------ENAAQALRSGGVVIVFPGGdydayRPTLAENVIDFngRKGYVRTAIDAGVPIVPAV 142
Cdd:pfam01553  75 daagtlEYLVELLREGKLVVIFPEG-----TRSREGELLPF--KKGAFRLAIEAGVPIVPVA 129
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 3-240 3.75e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 71.96  E-value: 3.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   3 VMRPAMKTY-FRSEVHGLGAFPP-GGALVVGNHSGgmfPMDVPIFTVHFyekfgyDRPVYTLSHDILMTGP-TGEFFRRT 79
Cdd:COG0204    19 WARLLLRLLgVRVRVEGLENLPAdGPVLIVANHQS---WLDILLLLAAL------PRPVRFVAKKELFKIPlLGWLLRAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  80 GYIRANREN----------AAQALRSGGVVIVFPGGdydayRPTLAENVIDFngRKGYVRTAIDAGVPIVPAVSIGGQET 149
Cdd:COG0204    90 GAIPVDRSKrraalralrqAVEALKAGESLVIFPEG-----TRSPDGRLLPF--KTGAARLALEAGVPIVPVAIDGTERA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 150 qlylsrgtwlaerlgikrllrsailplsfgFPFGFsavippnLPLPTKIVTQVLEPIDIAAQFGEdpDVDEVDEHVRSVM 229
Cdd:COG0204   163 ------------------------------LPKGF-------LPRPGKVTVRIGPPIDPSDLEGE--DRRELAERLRAAI 203

                         250
                  ....*....|.
gi 1783843773 230 QQALKDLAAKR 240
Cdd:COG0204   204 EALLAELRAEA 214
PLN02783 PLN02783
diacylglycerol O-acyltransferase
 3-241 3.98e-08

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 53.08  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   3 VMRPAMKtYF--RSEVHGLGAFPPGGALVVGNHSGGMFPMDVPIFTVHFYekFGYDRPVYTLSHDILMTGPtgeFFRRT- 79
Cdd:PLN02783   77 ICKYACA-YFpvRLHVEDEEAFDPNRAYVFGYEPHSVLPIGVIALADLSG--FLPLPKIRALASSAVFYTP---FLRHIw 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  80 ---GYIRANRENAAQALRSGGVVIVFPGGDYDAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPAVSIGGQETQLYLSRG 156
Cdd:PLN02783  151 twlGLDPASRKNFTSLLKAGYSCIIVPGGVQECLYMEHGSEVAYLKSRKGFVKIAMETGAPLVPVFCFGQTRAYKWWKPG 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 157 TWLAERLGikRLLRSAilPLSFGFPFGfsavIPpnLPLPTKIVTQVLEPIDIAAQfgEDPDVDEVDEHVRSVMqQALKDL 236
Cdd:PLN02783  231 GPLVPKLS--RAIGFT--PIVFWGRYG----SP--IPHRTPMHVVVGKPIEVKKN--PQPSQEEVAEVLEQFV-EALQDL 297


                  ....*
gi 1783843773 237 AAKRR 241
Cdd:PLN02783  298 FEKHK 302
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 25-142 1.77e-05

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 43.10  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  25 GGALVVGNHSGGMfpmDVPIFTVhfyekfGYDRP-VYTLSHDILMTGPTGEFFRRTGYIRANREN----------AAQAL 93
Cdd:TIGR00530  16 SPVLVVANHQSNL---DPLTLSA------AFPPPiVFIAKKELKWIPFFGIMLWLTGAIFIDRENiraiatalkaAIEVL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1783843773  94 RSGGVVIVFPGGdydayRPTLAENVIDFngRKGYVRTAIDAGVPIVPAV 142
Cdd:TIGR00530  87 KQGRSIGVFPEG-----TRSRGRDILPF--KKGAFHIAIKAGVPILPVV 128
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 8-241 4.45e-40

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 137.42  E-value: 4.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   8 MKTYFR-SEVHGLGAFPP-GGALVVGNHSGgmFPMDVPIFTVHFyEKFGYDRPVYTLSHDILMTGP-TGEFFRRTGYIRA 84
Cdd:cd07987     1 HRKYFRvYEVRGLENIPDeGPALLVHPHGG--LPIDGALLAAAF-LLLFPGRLPRALADHFLFPLPgLRDLLRRLGAVPG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  85 NRENAAQALRSGGVVIVFPGGDYDAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPAVSIGGQETQLYLSR-----GTWL 159
Cdd:cd07987    78 SRENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 160 AERLGIKRLLRsaiLPLSFGFpfgfsaviPPNLPLPTKivtqvlepidiaaQFGEDPDVDEVDEHVRsvmqQALKDLAAK 239
Cdd:cd07987   158 FRLLPLPRRLP---LYPVFGE--------PIVVPRPPI-------------PDPPDEDVEELHQKYI----AALRELIEK 209


                  ..
gi 1783843773 240 RR 241
Cdd:cd07987   210 HK 211
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 13-142 1.21e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.85  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  13 RSEVHGLGAFPP-GGALVVGNHSGgmfPMDVPIFTVHFYEkfgYDRPVYTLS-HDILMTGPTGEFFRRTGYIRANR---- 86
Cdd:pfam01553   1 RIEVHGLENLPRgGPAIVVANHQS---YLDVLLLSLALYK---RGRPLVFVAkKELFDIPLVGWLMRLLGCIFIDRknrk 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1783843773  87 ------ENAAQALRSGGVVIVFPGGdydayRPTLAENVIDFngRKGYVRTAIDAGVPIVPAV 142
Cdd:pfam01553  75 daagtlEYLVELLREGKLVVIFPEG-----TRSREGELLPF--KKGAFRLAIEAGVPIVPVA 129
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 3-240 3.75e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 71.96  E-value: 3.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   3 VMRPAMKTY-FRSEVHGLGAFPP-GGALVVGNHSGgmfPMDVPIFTVHFyekfgyDRPVYTLSHDILMTGP-TGEFFRRT 79
Cdd:COG0204    19 WARLLLRLLgVRVRVEGLENLPAdGPVLIVANHQS---WLDILLLLAAL------PRPVRFVAKKELFKIPlLGWLLRAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  80 GYIRANREN----------AAQALRSGGVVIVFPGGdydayRPTLAENVIDFngRKGYVRTAIDAGVPIVPAVSIGGQET 149
Cdd:COG0204    90 GAIPVDRSKrraalralrqAVEALKAGESLVIFPEG-----TRSPDGRLLPF--KTGAARLALEAGVPIVPVAIDGTERA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 150 qlylsrgtwlaerlgikrllrsailplsfgFPFGFsavippnLPLPTKIVTQVLEPIDIAAQFGEdpDVDEVDEHVRSVM 229
Cdd:COG0204   163 ------------------------------LPKGF-------LPRPGKVTVRIGPPIDPSDLEGE--DRRELAERLRAAI 203

                         250
                  ....*....|.
gi 1783843773 230 QQALKDLAAKR 240
Cdd:COG0204   204 EALLAELRAEA 214
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
 11-236 3.96e-11

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 61.68  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  11 YFRSEVHGLGAFPPGGALVVGNHSGGMFPMDVPI-FTVH---FYEKFGYDRPVytlshdiLMTGPtGEF---FRR----- 78
Cdd:pfam03982  48 YFPVKLHKTAELPPNRNYLFGYHPHGILSVGAFSnFSTNatgFMDKFPGIRPN-------ICTLA-GQFytpFRReills 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  79 TGYIRANRENAAQALRSGG----VVIVfPGGDYDAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPAVSIGgqETQLYL- 153
Cdd:pfam03982 120 LGLIEVSRESIEYVLDKCGkgraVVLV-VGGAAEALEAHPGKHTLTLKNRKGFVRIALKTGADLVPVYSFG--ENDVYKq 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 154 ------SRGTWLAERLgiKRLLRSAiLPLSFGFPFgFSAVIPPNLPLPTKIVTQVLEPIDIAAQfgEDPDVDEVDEhVRS 227
Cdd:pfam03982 197 wenpegSRLRWVQEKL--KRAIGFS-PPIFHGRGV-FNSYTFGLLPFRKPITTVVGAPIEVTKT--LNPTQEQIDE-LHG 269


                  ....*....
gi 1783843773 228 VMQQALKDL 236
Cdd:pfam03982 270 QYMEALREL 278
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 10-226 1.24e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 58.82  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  10 TYFRSEVHGLGAFPP-GGALVVGNHSGgmfPMDVPIFTVHFyekfgyDRPVYTLSHDILMTGP-TGEFFRRTGYIRANRE 87
Cdd:cd07989     8 LGVRVRVEGLENLPPkGPVIIVANHQS---YLDPLVLGAAL------PRPIRFVAKKELFKIPfLGWLLRLLGAIPIDRG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  88 N----------AAQALRSGGVVIVFPGGDYdayrpTLAENVIDFngRKGYVRTAIDAGVPIVPaVSIggqetqlylsRGT 157
Cdd:cd07989    79 NgrsarealreAIEALKEGESVVIFPEGTR-----SRDGELLPF--KSGAFRLAKEAGVPIVP-VAI----------SGT 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1783843773 158 WLAERLGIKRllrsailplsfgfpfgfsavippnlPLPTKIVTQVLEPIDIAAQFGEDPDVDEVDEHVR 226
Cdd:cd07989   141 WGSLPKGKKL-------------------------PRPGRVTVRIGEPIPPEGLELAEEDRKELREKVR 184
PLN02783 PLN02783
diacylglycerol O-acyltransferase
 3-241 3.98e-08

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 53.08  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   3 VMRPAMKtYF--RSEVHGLGAFPPGGALVVGNHSGGMFPMDVPIFTVHFYekFGYDRPVYTLSHDILMTGPtgeFFRRT- 79
Cdd:PLN02783   77 ICKYACA-YFpvRLHVEDEEAFDPNRAYVFGYEPHSVLPIGVIALADLSG--FLPLPKIRALASSAVFYTP---FLRHIw 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  80 ---GYIRANRENAAQALRSGGVVIVFPGGDYDAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPAVSIGGQETQLYLSRG 156
Cdd:PLN02783  151 twlGLDPASRKNFTSLLKAGYSCIIVPGGVQECLYMEHGSEVAYLKSRKGFVKIAMETGAPLVPVFCFGQTRAYKWWKPG 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773 157 TWLAERLGikRLLRSAilPLSFGFPFGfsavIPpnLPLPTKIVTQVLEPIDIAAQfgEDPDVDEVDEHVRSVMqQALKDL 236
Cdd:PLN02783  231 GPLVPKLS--RAIGFT--PIVFWGRYG----SP--IPHRTPMHVVVGKPIEVKKN--PQPSQEEVAEVLEQFV-EALQDL 297


                  ....*
gi 1783843773 237 AAKRR 241
Cdd:PLN02783  298 FEKHK 302
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 25-142 1.77e-05

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 43.10  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  25 GGALVVGNHSGGMfpmDVPIFTVhfyekfGYDRP-VYTLSHDILMTGPTGEFFRRTGYIRANREN----------AAQAL 93
Cdd:TIGR00530  16 SPVLVVANHQSNL---DPLTLSA------AFPPPiVFIAKKELKWIPFFGIMLWLTGAIFIDRENiraiatalkaAIEVL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1783843773  94 RSGGVVIVFPGGdydayRPTLAENVIDFngRKGYVRTAIDAGVPIVPAV 142
Cdd:TIGR00530  87 KQGRSIGVFPEG-----TRSRGRDILPF--KKGAFHIAIKAGVPILPVV 128
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 3-146 9.14e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 43.37  E-value: 9.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773    3 VMRPAMKTYFRSEVHGLGAFP-PGGALVVGNH----SGGMFPMDVPIFTVHFYEKFGYDRPVYTLSHDILMTGPTGeffr 77
Cdd:PRK08633   418 LLLLLMHTRYRLRVEGRENIPaKGGALLLGNHvswiDWALLQAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPIS---- 493

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1783843773   78 rTGYIRANRENAAQALRSGGVVIVFPggdydayrptlaENVIDFNG-----RKGYVRTAIDAGVPIVPaVSIGG 146
Cdd:PRK08633   494 -SGGSKESLEFIRKALDDGEVVCIFP------------EGAITRNGqlnefKRGFELIVKGTDVPIIP-FYIRG 553
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 15-175 1.23e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 41.85  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  15 EVHGLGAFPPGGALV-VGNHSGGMF-------------PmDVPIFTVHFYEKFGYDRPvYTLSHDILmtgpTGEFFRRTG 80
Cdd:cd07986    11 DVSGLENIPKDGPVViVANHPFGILdgliladllgsvrP-DVRILANQLLSKIPELRD-LFIPVDPL----EGRAALAKN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  81 yiRANRENAAQALRSGGVVIVFPGGDYdAYRPTLAENVIDFNGRKGYVRTAIDAGVPIVPaVSIGGQETQLYlsrgtWLA 160
Cdd:cd07986    85 --RESLREALRHLKNGGALIIFPAGRV-STASPPFGRVSDRPWNPFVARLARKAKAPVVP-VYFSGRNSRLF-----YLA 155

                         170
                  ....*....|....*
gi 1783843773 161 ERlgIKRLLRSAILP 175
Cdd:cd07986   156 GL--IHPTLRTLLLP 168
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 4-140 3.05e-04

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 40.48  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   4 MRPAMKTYFRSEVHGLGAFPPGGA-LVVGNHSGGMFPMdvPIFTVHFYekfGYDRPVYTLSHDILMtgPTGEFFRRTGYI 82
Cdd:cd06551     4 LLLNFFGFVRLEVKGPPPPPGGGPvLFVSNHSSWWDGL--ILFLLLER---GLRRDVYGLMDEELL--ERYPFFTRLGAF 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1783843773  83 ---RANRENAAQALRS--------GGVVIVFPGGDYDayrpTLAENVIDFngRKGYVRTAIDAGVPIVP 140
Cdd:cd06551    77 svdRDSPRSAAKSLKYvarllskpGSVVWIFPEGTRT----RRDKRPLQF--KPGVAHLAEKAGVPIVP 139
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 3-140 3.88e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 40.32  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773   3 VMRPAMKTYFRS-EVHGLGAFPPGGA-LVVGNHSGGMfpMDVPIFTVHfyekfgYDRPV-YTLSHDILMTGPTGEFFR-- 77
Cdd:cd07992     4 LSRVILRIYFRRiTVVGRENVPKDGPvIFLGNHPNAL--IDPLLLAAT------LRRPVrFLAKADLFKNPLIGWLLEsf 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783843773  78 ------------RTGYIRANRENA----AQALRSGGVVIVFP-GGDYDayRPTLAenvidfNGRKGYVRTAIDA------ 134
Cdd:cd07992    76 gaipvyrpkdlaRGGIGKISNAAVfdavGEALKAGGAIGIFPeGGSHD--RPRLL------PLKAGAARMALEAleagqk 147


                  ....*.
gi 1783843773 135 GVPIVP 140
Cdd:cd07992   148 DVKIVP 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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