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Conserved domains on  [gi|1767029687|ref|WP_151877525|]
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N-6 DNA methylase [Bacteroides uniformis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HsdM super family cl33828
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
85-186 6.04e-16

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


The actual alignment was detected with superfamily member COG0286:

Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 74.45  E-value: 6.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767029687  85 DALGDLFMALSSRKGQQAQ---GQFFTPVHICDLMVMCTETDEkktGQRINDPTCGSGRLLLA---YHVRHLGN-----Y 153
Cdd:COG0286     1 DVLGDAYEYLLRKFAEESGkkaGEFYTPREVVRLMVELLDPKP---GETVYDPACGSGGFLVEaaeYLKEHGGDerkklS 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1767029687 154 LVAEDVNRTCCLMTICNMLIHGCVGEVIHH-DSL 186
Cdd:COG0286    78 LYGQEINPTTYRLAKMNLLLHGIGDPNIELgDTL 111
 
Name Accession Description Interval E-value
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
85-186 6.04e-16

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 74.45  E-value: 6.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767029687  85 DALGDLFMALSSRKGQQAQ---GQFFTPVHICDLMVMCTETDEkktGQRINDPTCGSGRLLLA---YHVRHLGN-----Y 153
Cdd:COG0286     1 DVLGDAYEYLLRKFAEESGkkaGEFYTPREVVRLMVELLDPKP---GETVYDPACGSGGFLVEaaeYLKEHGGDerkklS 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1767029687 154 LVAEDVNRTCCLMTICNMLIHGCVGEVIHH-DSL 186
Cdd:COG0286    78 LYGQEINPTTYRLAKMNLLLHGIGDPNIELgDTL 111
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 84-198 6.54e-09

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 55.02  E-value: 6.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767029687  84 YDALGDLFMALSSRKGQQA---QGQFFTPVHICDLMVMCTETdekKTGQRINDPTCGSGRLLLA---YHVRHLGN----Y 153
Cdd:pfam02384   2 RDLFGDAYEYLLRKFAPNAgksGGEFFTPREVSKLIVELLDP---KPGESIYDPACGSGGFLIQaekFVKEHDGDtndlS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1767029687 154 LVAEDVNRTCCLMTICNMLIHGCVG---EVIHHDSLCPENF-----MDGWMAN 198
Cdd:pfam02384  79 IYGQEKNPTTYRLARMNMILHGIEYddfHIRHGDTLTSPKFeddkkFDVVVAN 131
 
Name Accession Description Interval E-value
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
85-186 6.04e-16

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 74.45  E-value: 6.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767029687  85 DALGDLFMALSSRKGQQAQ---GQFFTPVHICDLMVMCTETDEkktGQRINDPTCGSGRLLLA---YHVRHLGN-----Y 153
Cdd:COG0286     1 DVLGDAYEYLLRKFAEESGkkaGEFYTPREVVRLMVELLDPKP---GETVYDPACGSGGFLVEaaeYLKEHGGDerkklS 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1767029687 154 LVAEDVNRTCCLMTICNMLIHGCVGEVIHH-DSL 186
Cdd:COG0286    78 LYGQEINPTTYRLAKMNLLLHGIGDPNIELgDTL 111
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 84-198 6.54e-09

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 55.02  E-value: 6.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767029687  84 YDALGDLFMALSSRKGQQA---QGQFFTPVHICDLMVMCTETdekKTGQRINDPTCGSGRLLLA---YHVRHLGN----Y 153
Cdd:pfam02384   2 RDLFGDAYEYLLRKFAPNAgksGGEFFTPREVSKLIVELLDP---KPGESIYDPACGSGGFLIQaekFVKEHDGDtndlS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1767029687 154 LVAEDVNRTCCLMTICNMLIHGCVG---EVIHHDSLCPENF-----MDGWMAN 198
Cdd:pfam02384  79 IYGQEKNPTTYRLARMNMILHGIEYddfHIRHGDTLTSPKFeddkkFDVVVAN 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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