|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
1-415 |
2.37e-166 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 473.87 E-value: 2.37e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 1 MSKYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQK-VQAVITAPT 79
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRaPQALILAPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 80 RELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDM 159
Cdd:COG0513 81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 160 GFIEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYLIPTRSKSRNTKLLEVMDAIN 239
Cdd:COG0513 161 GFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 240 PYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQ 319
Cdd:COG0513 241 PERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 320 DLEFFIHRVGRTARAGNKGLAITLFEPSDEDAIVRVEK-MGIPFVPKDIKNGEIIEMKERHARQNREKKVDEIDQIAKSR 398
Cdd:COG0513 321 DPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKlIGQKIEEEELPGFEPVEEKRLERLKPKIKEKLKGKKAGRGG 400
|
410
....*....|....*..
gi 1752084991 399 VRKPKKVKPGYKRNMRW 415
Cdd:COG0513 401 RPGPKGERKARRGKRRR 417
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
13-204 |
8.43e-84 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 255.06 E-value: 8.43e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQK----VQAVITAPTRELATQIHA 88
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKkgrgPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 89 ELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQF 168
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 1752084991 169 ATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIH 204
Cdd:cd00268 161 LSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
1-368 |
5.72e-82 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 259.35 E-value: 5.72e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 1 MSKYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTR 80
Cdd:PRK11776 3 MTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 81 ELATQIHAELMKIIEKTD-IHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDM 159
Cdd:PRK11776 83 ELADQVAKEIRRLARFIPnIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 160 GFIEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIHMnDKKPVAENID--FYLIptrskSRNTKLLEVMDA 237
Cdd:PRK11776 163 GFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKV-ESTHDLPAIEqrFYEV-----SPDERLPALQRL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 238 IN---PYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVIN 314
Cdd:PRK11776 237 LLhhqPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVIN 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1752084991 315 YELPQDLEFFIHRVGRTARAGNKGLAITLFEPSDEDAIVRVEK-MGIPFVPKDIK 368
Cdd:PRK11776 317 YELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDyLGRKLNWEPLP 371
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
3-343 |
4.59e-76 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 242.95 E-value: 4.59e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 3 KYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVER-----IKQDEQKVQ--AVI 75
Cdd:PRK04837 9 KFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYllshpAPEDRKVNQprALI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 76 TAPTRELATQIHAELMKIIEKTDIHAKLFIGGT--DKQRSidKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEA 153
Cdd:PRK04837 89 MAPTRELAVQIHADAEPLAQATGLKLGLAYGGDgyDKQLK--VLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 154 DLAFDMGFIEDIDQFATQMP---ENLEMyVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENID---FYliptrsKSR 227
Cdd:PRK04837 167 DRMFDLGFIKDIRWLFRRMPpanQRLNM-LFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKeelFY------PSN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 228 NTK---LLEVMDAINPYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGI 304
Cdd:PRK04837 240 EEKmrlLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGL 319
|
330 340 350
....*....|....*....|....*....|....*....
gi 1752084991 305 DIPGVSHVINYELPQDLEFFIHRVGRTARAGNKGLAITL 343
Cdd:PRK04837 320 HIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
4-357 |
1.86e-68 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 222.78 E-value: 1.86e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELA 83
Cdd:PTZ00424 30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 84 TQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIE 163
Cdd:PTZ00424 110 QQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFKG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 164 DIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENI-DFYLIPTRSKSRNTKLLEVMDAINPYL 242
Cdd:PTZ00424 190 QIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIrQFYVAVEKEEWKFDTLCDLYETLTITQ 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 243 AIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQDLE 322
Cdd:PTZ00424 270 AIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPE 349
|
330 340 350
....*....|....*....|....*....|....*
gi 1752084991 323 FFIHRVGRTARAGNKGLAITLFEPSDEDAIVRVEK 357
Cdd:PTZ00424 350 NYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIER 384
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
4-385 |
5.29e-68 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 226.37 E-value: 5.29e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERI-------KQDEQKVQAVIT 76
Cdd:PRK04537 11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpalaDRKPEDPRALIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 77 APTRELATQIHAELMKIIEKTDIHAKLFIGGTD--KQRSIdkLKSQPQIVVGTPGRIRDLVKEQALL-VHTASILVVDEA 153
Cdd:PRK04537 91 APTRELAIQIHKDAVKFGADLGLRFALVYGGVDydKQREL--LQQGVDVIIATPGRLIDYVKQHKVVsLHACEICVLDEA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 154 DLAFDMGFIEDIDQFATQMPE--NLEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYLIPTRSKSRNTKL 231
Cdd:PRK04537 169 DRMFDLGFIKDIRFLLRRMPErgTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 232 LEVMDAINPYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSH 311
Cdd:PRK04537 249 LGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKY 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 312 VINYELPQDLEFFIHRVGRTARAGNKGLAITL---------------------FEPSDEDAIV---RVEKMGIPFVPKDI 367
Cdd:PRK04537 329 VYNYDLPFDAEDYVHRIGRTARLGEEGDAISFaceryamslpdieayieqkipVEPVTAELLTplpRPPRVPVEGEEADD 408
|
410
....*....|....*...
gi 1752084991 368 KNGEIIEMKERHARQNRE 385
Cdd:PRK04537 409 EAGDSVGTIFREAREQRA 426
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
2-358 |
6.79e-68 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 223.25 E-value: 6.79e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 2 SKYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQD---EQK----VQAV 74
Cdd:PRK01297 87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTpppKERymgePRAL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 75 ITAPTRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQ-PQIVVGTPGRIRDLVKEQALLVHTASILVVDEA 153
Cdd:PRK01297 167 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 154 DLAFDMGFIEDIDQFATQMP--ENLEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYLIPTrSKSRNTKL 231
Cdd:PRK01297 247 DRMLDMGFIPQVRQIIRQTPrkEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAV-AGSDKYKL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 232 LEVMDAINPY-LAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVS 310
Cdd:PRK01297 326 LYNLVTQNPWeRVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGIS 405
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1752084991 311 HVINYELPQDLEFFIHRVGRTARAGNKGLAITLFEPSDEDAIVRVEKM 358
Cdd:PRK01297 406 HVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEEL 453
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
4-373 |
2.43e-67 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 225.88 E-value: 2.43e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELA 83
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 84 TQIhAELMKIIEK--TDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGF 161
Cdd:PRK11634 88 VQV-AEAMTDFSKhmRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 162 IEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYLIPTRSKSRNTKLLEVMDAINPY 241
Cdd:PRK11634 167 IEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEAEDFD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 242 LAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQDL 321
Cdd:PRK11634 247 AAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDS 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1752084991 322 EFFIHRVGRTARAGNKGLAITLFEPSDEDAIVRVE---KMGIPFVpkDIKNGEII 373
Cdd:PRK11634 327 ESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIErtmKLTIPEV--ELPNAELL 379
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
4-406 |
1.84e-66 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 218.27 E-value: 1.84e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVE------RIKQDEQKVqaVITA 77
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQhlldfpRRKSGPPRI--LILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 78 PTRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAF 157
Cdd:PRK11192 81 PTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRML 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 158 DMGFIEDIDQFATQMPENLEMYVFSATVP-ESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYLIPTRSKSRNTKLLE-VM 235
Cdd:PRK11192 161 DMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEVEAEPSRRERKKIHQWYYRADDLEHKTALLChLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 236 DAINPYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINY 315
Cdd:PRK11192 241 KQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 316 ELPQDLEFFIHRVGRTARAGNKGLAITLFEPSDEDAIVRVEKmgipFVPKDIKNGEIIEMKERH------ARQNREKKVD 389
Cdd:PRK11192 321 DMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIER----YIEEPLKARVIDELRPKTkapsekKTGKPSKKVL 396
|
410
....*....|....*..
gi 1752084991 390 EIDQIAKSRVRKPKKVK 406
Cdd:PRK11192 397 AKRAEKKEKEKEKPKVK 413
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
16-343 |
1.42e-61 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 206.20 E-value: 1.42e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 16 AIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQK------VQAVITAPTRELATQIHAE 89
Cdd:PRK10590 15 AVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHakgrrpVRALILTPTRELAAQIGEN 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 90 LMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFA 169
Cdd:PRK10590 95 VRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 170 TQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYlIPTRSKSRNTKLLEVMDAINPYLAI-IFTN 248
Cdd:PRK10590 175 AKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQH-VHFVDKKRKRELLSQMIGKGNWQQVlVFTR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 249 TRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQDLEFFIHRV 328
Cdd:PRK10590 254 TKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRI 333
|
330
....*....|....*
gi 1752084991 329 GRTARAGNKGLAITL 343
Cdd:PRK10590 334 GRTGRAAATGEALSL 348
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
9-346 |
3.58e-57 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 196.92 E-value: 3.58e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 9 FQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERI-------KQDEQKVqaVITAPTRE 81
Cdd:PTZ00110 137 FPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHInaqpllrYGDGPIV--LVLAPTRE 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 82 LATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGF 161
Cdd:PTZ00110 215 LAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGF 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 162 IEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYM-EAPVHIHMNDKKPVA-ENI--DFYLIPTRSKSRNTKLL--EVM 235
Cdd:PTZ00110 295 EPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCkEEPVHVNVGSLDLTAcHNIkqEVFVVEEHEKRGKLKMLlqRIM 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 236 DAiNPYLaIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINY 315
Cdd:PTZ00110 375 RD-GDKI-LIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINF 452
|
330 340 350
....*....|....*....|....*....|.
gi 1752084991 316 ELPQDLEFFIHRVGRTARAGNKGLAITLFEP 346
Cdd:PTZ00110 453 DFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
15-203 |
1.33e-53 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 177.07 E-value: 1.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 15 EAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQIHAELMKII 94
Cdd:cd17943 3 EGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 95 EK-TDIHAKLFIGGTDKQRSIDKLKsQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFATQMP 173
Cdd:cd17943 83 KKlEGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSSLP 161
|
170 180 190
....*....|....*....|....*....|
gi 1752084991 174 ENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17943 162 KNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
4-384 |
3.69e-52 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 182.68 E-value: 3.69e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQ-------DEQKVQAVIT 76
Cdd:PLN00206 123 FSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTirsghpsEQRNPLAMVL 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 77 APTRELATQIHaELMKIIEK-TDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADL 155
Cdd:PLN00206 203 TPTRELCVQVE-DQAKVLGKgLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDC 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 156 AFDMGFIEDIDQF--ATQMPenlEMYVFSATVPESLQPFLRKYMEAPVHIHMNDKKPVAENIDFYLIPTRSKSRNTKLLE 233
Cdd:PLN00206 282 MLERGFRDQVMQIfqALSQP---QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFD 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 234 VMDAINPYL--AIIFTNTRKQAEAVANFLS-SNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVS 310
Cdd:PLN00206 359 ILKSKQHFKppAVVFVSSRLGADLLANAITvVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVR 438
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752084991 311 HVINYELPQDLEFFIHRVGRTARAGNKGLAITLFEPSDED---AIVRVEKMGIPFVPKDIKNGEIIEMKERHARQNR 384
Cdd:PLN00206 439 QVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNlfpELVALLKSSGAAIPRELANSRYLGSGRKRKKKRR 515
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
215-344 |
1.15e-51 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 170.00 E-value: 1.15e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 215 IDFYLIPTRSKSRNTKLL-EVMDAINPYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQY 293
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1752084991 294 IVATDLAARGIDIPGVSHVINYELPQDLEFFIHRVGRTARAGNKGLAITLF 344
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
26-190 |
2.45e-50 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 167.80 E-value: 2.45e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 26 TPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQIHAELMKIIEKTDIHAKLFI 105
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 106 GGTDKQRSIDKLKSqPQIVVGTPGRIRDLVKEQALLvHTASILVVDEADLAFDMGFIEDIDQFATQMPENLEMYVFSATV 185
Cdd:pfam00270 81 GGDSRKEQLEKLKG-PDILVGTPGRLLDLLQERKLL-KNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATL 158
|
....*
gi 1752084991 186 PESLQ 190
Cdd:pfam00270 159 PRNLE 163
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
8-203 |
3.49e-50 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 168.64 E-value: 3.49e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 8 NFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKV--QAVITAPTRELATQ 85
Cdd:cd17959 7 GLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTVgaRALILSPTRELALQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 86 IHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDI 165
Cdd:cd17959 87 TLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLFEMGFAEQL 166
|
170 180 190
....*....|....*....|....*....|....*...
gi 1752084991 166 DQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17959 167 HEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
13-203 |
5.05e-48 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 163.13 E-value: 5.05e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQK-----VQAVITAPTRELATQIH 87
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANlkkgqVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 88 AELMKIIEKTDIHAK--LFIGGTDKQRSIDKLKSQ-PQIVVGTPGRIRDLVKEQALLVHTAS--ILVVDEADLAFDMGFI 162
Cdd:cd17960 81 EVLQSFLEHHLPKLKcqLLIGGTNVEEDVKKFKRNgPNILVGTPGRLEELLSRKADKVKVKSleVLVLDEADRLLDLGFE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1752084991 163 EDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
13-203 |
2.80e-47 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 160.83 E-value: 2.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQK--VQAVITAPTRELATQIHAEL 90
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKKkgLRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 91 MKIIEKTDIHAKLFIGGT-DKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFA 169
Cdd:cd17957 81 LKLSKGTGLRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEIL 160
|
170 180 190
....*....|....*....|....*....|....*
gi 1752084991 170 TQMPE-NLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17957 161 AACTNpNLQRSLFSATIPSEVEELARSVMKDPIRI 195
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
4-203 |
2.17e-46 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 158.62 E-value: 2.17e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELA 83
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 84 TQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIE 163
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQP 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1752084991 164 DIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17940 161 IIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
16-203 |
3.10e-46 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 158.19 E-value: 3.10e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 16 AIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERI---KQDEQKVQAVITAPTRELATQIHAELMK 92
Cdd:cd17947 4 ALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQCFSVLQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 93 IIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKE-QALLVHTASILVVDEADLAFDMGFIEDIDQFATQ 171
Cdd:cd17947 84 LAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNsPSFDLDSIEILVLDEADRMLEEGFADELKEILRL 163
|
170 180 190
....*....|....*....|....*....|..
gi 1752084991 172 MPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17947 164 CPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
17-218 |
3.11e-44 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 153.03 E-value: 3.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 17 IKELGFTEPTPIQKEMIPLILKG-KSAIGQAHTGTGKTHSFLIPIVERIKQDEQKvQAVITAPTRELATQIHAELMKIIE 95
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG-RVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 96 KTDIHAKLFIGGTDKQRSIDKLKS-QPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFATQMPE 174
Cdd:smart00487 80 SLGLKVVGLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1752084991 175 NLEMYVFSATVPESLQPFLRKYMEAPVHIhmNDKKPVAENIDFY 218
Cdd:smart00487 160 NVQLLLLSATPPEEIENLLELFLNDPVFI--DVGFTPLEPIEQF 201
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
4-203 |
3.35e-44 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 152.99 E-value: 3.35e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELA 83
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 84 TQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIE 163
Cdd:cd18046 81 QQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFKD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1752084991 164 DIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd18046 161 QIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
9-197 |
1.40e-43 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 151.58 E-value: 1.40e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 9 FQPFLREAIKELGFTEPTPIQKEMIPLIL-KGKSAIGQAHTGTGKTHSFLIPIVERI-----KQDEQKVQAVITAPTREL 82
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLlntkpAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 83 ATQIHAELMKIIEK-TDIHAKLFIGGTDKQRSIDKLKSQ-PQIVVGTPGRIRDLVKEQALLVHTASI--LVVDEADLAFD 158
Cdd:cd17964 81 ALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAELNRLRRGrPDILVATPGRLIDHLENPGVAKAFTDLdyLVLDEADRLLD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1752084991 159 MGFIEDIDQFATQMPENLEM----YVFSATVPESLQPFLRKYM 197
Cdd:cd17964 161 MGFRPDLEQILRHLPEKNADprqtLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
11-201 |
6.27e-43 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 149.66 E-value: 6.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 11 PFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERI---KQD---EQKVQAVITAPTRELAT 84
Cdd:cd17961 3 PRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkaKAEsgeEQGTRALILVPTRELAQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 85 QIHAELMKIIEKTDIHAKL--FIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLV-HTASILVVDEADLAFDMGF 161
Cdd:cd17961 83 QVSKVLEQLTAYCRKDVRVvnLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLlSTLKYLVIDEADLVLSYGY 162
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1752084991 162 IEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPV 201
Cdd:cd17961 163 EEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
4-196 |
2.20e-42 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 148.79 E-value: 2.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQD----------EQKVQA 73
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDgppsvgrgrrKAYPSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 74 VITAPTRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEA 153
Cdd:cd17967 82 LILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDEA 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1752084991 154 DLAFDMGFIEDIDQFATQ--MPENLE----MyvFSATVPESLQ----PFLRKY 196
Cdd:cd17967 162 DRMLDMGFEPQIRKIVEHpdMPPKGErqtlM--FSATFPREIQrlaaDFLKNY 212
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
4-203 |
4.25e-42 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 147.46 E-value: 4.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELA 83
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 84 TQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRD-LVKEQALLVHTASILVVDEADLAFDMGFI 162
Cdd:cd17954 82 QQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDhLENTKGFSLKSLKFLVMDEADRLLNMDFE 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1752084991 163 EDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17954 162 PEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
16-203 |
2.72e-41 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 145.98 E-value: 2.72e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 16 AIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKqDEQKVQ------AVITAPTRELATQIHAE 89
Cdd:cd17953 26 LIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIK-DQRPVKpgegpiGLIMAPTRELALQIYVE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 90 LMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLV---HTASILVVDEADLAFDMGFIEDID 166
Cdd:cd17953 105 CKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGRVtnlRRVTYVVLDEADRMFDMGFEPQIM 184
|
170 180 190
....*....|....*....|....*....|....*..
gi 1752084991 167 QFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17953 185 KIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
6-203 |
3.64e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 144.77 E-value: 3.64e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 6 DYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQ 85
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 86 IHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDI 165
Cdd:cd17939 81 IQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQI 160
|
170 180 190
....*....|....*....|....*....|....*...
gi 1752084991 166 DQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17939 161 YDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
4-201 |
4.85e-41 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 144.67 E-value: 4.85e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELA 83
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 84 TQIhAELMKIIEK-TDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVK---EQALLVHTASILVVDEADLAFDM 159
Cdd:cd17955 81 YQI-AEQFRALGApLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVLSRVKFLVLDEADRLLTG 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1752084991 160 GFIEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPV 201
Cdd:cd17955 160 SFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
13-203 |
1.25e-40 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 144.00 E-value: 1.25e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERI----KQDEQKVQ----AVITAPTRELAT 84
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYIsrlpPLDEETKDdgpyALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 85 QIHAELMKIIEKTDIHAKLFIGGtdkqRSID----KLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMG 160
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGG----HSIEeqafSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMG 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1752084991 161 FIEDIDQFATQMPENLEM--------------------YVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17945 157 FEPQVTKILDAMPVSNKKpdteeaeklaasgkhryrqtMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
2-203 |
3.29e-39 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 140.17 E-value: 3.29e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 2 SKYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRE 81
Cdd:cd17950 2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 82 LATQIHAELMKIIE-KTDIHAKLFIGGTDKQRSIDKLKS-QPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADL---A 156
Cdd:cd17950 82 LAFQISNEYERFSKyMPNVKTAVFFGGVPIKKDIEVLKNkCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKmleQ 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1752084991 157 FDMGfiEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17950 162 LDMR--RDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
8-198 |
6.96e-39 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 140.87 E-value: 6.96e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 8 NFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDE---------QKVQAVITAP 78
Cdd:cd18052 49 NLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGltassfsevQEPQALIVAP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 79 TRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFD 158
Cdd:cd18052 129 TRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDEADRMLD 208
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1752084991 159 MGFIEDIDQFATQ--MP--ENLEMYVFSATVPESLQPFLRKYME 198
Cdd:cd18052 209 MGFGPEIRKLVSEpgMPskEDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
13-204 |
8.13e-39 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 138.70 E-value: 8.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIP-IVERIKQDEQKVQ----AVITAPTRELATQIH 87
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPmLVHIMDQRELEKGegpiAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 88 AELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQ 167
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRS 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 1752084991 168 FATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIH 204
Cdd:cd17952 161 IVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
16-203 |
1.82e-38 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 137.81 E-value: 1.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 16 AIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQD----EQKVQAVITAPTRELATQIHAELM 91
Cdd:cd17941 4 GLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRErwtpEDGLGALIISPTRELAMQIFEVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 92 KIIEKTDIHAKLFIGGTDKQRSIDKLkSQPQIVVGTPGRIRDLVKEQALLVHTA-SILVVDEADLAFDMGFIEDIDQFAT 170
Cdd:cd17941 84 KVGKYHSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPGFDTSNlQMLVLDEADRILDMGFKETLDAIVE 162
|
170 180 190
....*....|....*....|....*....|...
gi 1752084991 171 QMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17941 163 NLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
11-184 |
1.28e-37 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 135.53 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 11 PFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVerikqdeQKVQAVITAPTRELATQIHAEL 90
Cdd:cd17938 8 PELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL-------QIVVALILEPSRELAEQTYNCI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 91 M---KIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQ 167
Cdd:cd17938 81 EnfkKYLDNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNLETINR 160
|
170 180
....*....|....*....|...
gi 1752084991 168 FATQMPE------NLEMYVFSAT 184
Cdd:cd17938 161 IYNRIPKitsdgkRLQVIVCSAT 183
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
15-203 |
4.45e-36 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 131.43 E-value: 4.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 15 EAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIP----IVERIKQDEQKVQA--VITAPTRELATQIHA 88
Cdd:cd17958 3 KEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgfihLDLQPIPREQRNGPgvLVLTPTRELALQIEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 89 ELMKIIEKtDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQF 168
Cdd:cd17958 83 ECSKYSYK-GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKI 161
|
170 180 190
....*....|....*....|....*....|....*
gi 1752084991 169 ATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17958 162 LLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
15-204 |
7.50e-36 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 130.57 E-value: 7.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 15 EAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQ-----AVITAPTRELATQIHAE 89
Cdd:cd17966 3 DELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERgdgpiVLVLAPTRELAQQIQQE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 90 LMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFA 169
Cdd:cd17966 83 ANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIV 162
|
170 180 190
....*....|....*....|....*....|....*
gi 1752084991 170 TQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIH 204
Cdd:cd17966 163 DQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
17-203 |
2.61e-34 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 126.51 E-value: 2.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 17 IKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQIH---AELMKI 93
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEdqaKELMKG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 94 IEKtdIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFATQMP 173
Cdd:cd17962 85 LPP--MKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILENIS 162
|
170 180 190
....*....|....*....|....*....|
gi 1752084991 174 ENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17962 163 HDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
17-199 |
3.04e-34 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 126.50 E-value: 3.04e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 17 IKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKV------QAVITAPTRELATQIHAEL 90
Cdd:cd17944 5 LQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRkrgrapKVLVLAPTRELANQVTKDF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 91 MKIIEKTDIHAklFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQ--- 167
Cdd:cd17944 85 KDITRKLSVAC--FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEils 162
|
170 180 190
....*....|....*....|....*....|....
gi 1752084991 168 --FATQMPENLEMYVFSATVPESLQPFLRKYMEA 199
Cdd:cd17944 163 vsYKKDSEDNPQTLLFSATCPDWVYNVAKKYMKS 196
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
16-184 |
3.18e-34 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 126.32 E-value: 3.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 16 AIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIkqdeQKVQ--------AVITAPTRELATQIH 87
Cdd:cd17942 4 AIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELL----YKLKfkprngtgVIIISPTRELALQIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 88 A---ELMKIIEKTdihAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRD-LVKEQALLVHTASILVVDEADLAFDMGFIE 163
Cdd:cd17942 80 GvakELLKYHSQT---FGIVIGGANRKAEAEKLGKGVNILVATPGRLLDhLQNTKGFLYKNLQCLIIDEADRILEIGFEE 156
|
170 180
....*....|....*....|.
gi 1752084991 164 DIDQFATQMPENLEMYVFSAT 184
Cdd:cd17942 157 EMRQIIKLLPKRRQTMLFSAT 177
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
13-195 |
7.07e-34 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 126.58 E-value: 7.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILK-GKSAIGQAHTGTGKTHSFLIPIVERIKQDEQK---------VQAVITAPTREL 82
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLSQKSSngvggkqkpLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 83 ATQIHAELMKIIEKTDIHAKLFIGG--TDKQRSIdkLKSQPQIVVGTPGRIRDLVKE-QALL--VHTASILVVDEADLAF 157
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGlaVQKQERL--LKKRPEIVVATPGRLWELIQEgNEHLanLKSLRFLVLDEADRML 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1752084991 158 DMGFIEDIDQFATQMPENLEMY-------VFSATVPESLQPFLRK 195
Cdd:cd17946 159 EKGHFAELEKILELLNKDRAGKkrkrqtfVFSATLTLDHQLPLKL 203
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
13-203 |
8.39e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 125.27 E-value: 8.39e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQIHAELMK 92
Cdd:cd18045 10 LLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 93 IIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFATQM 172
Cdd:cd18045 90 LGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFKEQIYDVYRYL 169
|
170 180 190
....*....|....*....|....*....|.
gi 1752084991 173 PENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd18045 170 PPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
11-203 |
7.15e-33 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 122.68 E-value: 7.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 11 PFLREAIKELGFTEPTPIQKEMIPLILKG--KSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQIHA 88
Cdd:cd17963 3 PELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQIGE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 89 ELMKIIEKTDIHAKLFIGGTDKQRSidkLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDM-GFIEDIDQ 167
Cdd:cd17963 83 VVEKMGKFTGVKVALAVPGNDVPRG---KKITAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGDQSIR 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 1752084991 168 FATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17963 160 IKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
13-195 |
3.14e-31 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 119.39 E-value: 3.14e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQ-------AVITAPTRELATQ 85
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEgpfnaprGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 86 IHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDI 165
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1752084991 166 D------QFATQMPENLE-------MYVFSATVPESLQPFLRK 195
Cdd:cd17948 161 ShflrrfPLASRRSENTDgldpgtqLVLVSATMPSGVGEVLSK 203
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
226-335 |
2.20e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 113.07 E-value: 2.20e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 226 SRNTKLLEVMDAINPYLAIIFTNTRKQAEAvANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGID 305
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 1752084991 306 IPGVSHVINYELPQDLEFFIHRVGRTARAG 335
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
3-205 |
2.67e-30 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 117.03 E-value: 2.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 3 KYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIK-----QDEQKVQAVITA 77
Cdd:cd18049 25 NFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINhqpflERGDGPICLVLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 78 PTRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAF 157
Cdd:cd18049 105 PTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRML 184
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1752084991 158 DMGFIEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAPVHIHM 205
Cdd:cd18049 185 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
20-167 |
4.45e-30 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 115.76 E-value: 4.45e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 20 LGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQ------AVITAPTRELATQIHAELMKI 93
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDrsdgtlALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1752084991 94 IEK-TDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRD-LVKEQALLVHTASILVVDEADLAFDMGFIEDIDQ 167
Cdd:cd17949 89 LKPfHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDhLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITK 164
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
1-198 |
1.30e-29 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 115.52 E-value: 1.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 1 MSKYSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQD------------- 67
Cdd:cd18051 20 IETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQgpgeslpsesgyy 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 68 ---EQKVQAVITAPTRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHT 144
Cdd:cd18051 100 grrKQYPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGLDY 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1752084991 145 ASILVVDEADLAFDMGFIEDIDQFATQ--MPENLE--MYVFSATVPESLQPFLRKYME 198
Cdd:cd18051 180 CKYLVLDEADRMLDMGFEPQIRRIVEQdtMPPTGErqTLMFSATFPKEIQMLARDFLD 237
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
16-203 |
1.87e-29 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 113.97 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 16 AIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQ--------AVITAPTRELATQIH 87
Cdd:cd17951 4 GLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPfikgegpyGLIVCPSRELARQTH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 88 aELMKIIEKT-------DIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMG 160
Cdd:cd17951 84 -EVIEYYCKAlqeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMG 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1752084991 161 FIEDI----DQFATQMpenlEMYVFSATVPESLQPFLRKYMEAPVHI 203
Cdd:cd17951 163 FEEDIrtifSYFKGQR----QTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
8-198 |
5.79e-26 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 106.25 E-value: 5.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 8 NFQPFLREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQA-----VITAPTREL 82
Cdd:cd18050 68 NFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGdgpicLVLAPTREL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 83 ATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFI 162
Cdd:cd18050 148 AQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFE 227
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1752084991 163 EDIDQFATQMPENLEMYVFSATVPESL----QPFLRKYME 198
Cdd:cd18050 228 PQIRKIVDQIRPDRQTLMWSATWPKEVrqlaEDFLRDYVQ 267
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
254-335 |
1.18e-25 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 99.59 E-value: 1.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 254 EAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQDLEFFIHRVGRTAR 333
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1752084991 334 AG 335
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
13-154 |
1.60e-24 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 101.17 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKG-KSAIGQ--------AHTGTGKTHSFLIPIVERIKQDE-QKVQAVITAPTREL 82
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSsKSTPPYrpgdlcvsAPTGSGKTLAYVLPIVQALSKRVvPRLRALIVVPTKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 83 ATQIHAELMKIIEKTDIHAKLFIGGTD---KQRSIDKLKSQ-----PQIVVGTPGRIRD-LVKEQALLVHTASILVVDEA 153
Cdd:cd17956 81 VQQVYKVFESLCKGTGLKVVSLSGQKSfkkEQKLLLVDTSGrylsrVDILVATPGRLVDhLNSTPGFTLKHLRFLVIDEA 160
|
.
gi 1752084991 154 D 154
Cdd:cd17956 161 D 161
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
11-195 |
7.22e-23 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 97.06 E-value: 7.22e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 11 PFLREAI---------KELGFTEPTPIQKEMIPLILK---GKSAIGQ-------------AHTGTGKTHSFLIPIVERIK 65
Cdd:cd17965 8 PSVREAIikeilkgsnKTDEEIKPSPIQTLAIKKLLKtlmRKVTKQTsneepklevfllaAETGSGKTLAYLAPLLDYLK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 66 QDEQ-----------------KVQAVITAPTRELATQIHAELMKIIEKTDIHAKLFIG--GTDKQRSIDKLKSQPQIVVG 126
Cdd:cd17965 88 RQEQepfeeaeeeyesakdtgRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSgfGPSYQRLQLAFKGRIDILVT 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752084991 127 TPGRIRDLVKEQALLVHTASILVVDEADLAFDMGFIEDIDQFATQMPENLEMYVFSATVPESLQPFLRK 195
Cdd:cd17965 168 TPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRK 236
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
13-200 |
2.05e-20 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 89.70 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKG--KSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRELATQIHael 90
Cdd:cd18048 29 LLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTFELALQTG--- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 91 mKIIEK-----TDIHAKLFIGGTDKQRSIDKLKsqpQIVVGTPGRIRD-LVKEQALLVHTASILVVDEADLAFDM-GFIE 163
Cdd:cd18048 106 -KVVEEmgkfcVGIQVIYAIRGNRPGKGTDIEA---QIVIGTPGTVLDwCFKLRLIDVTNISVFVLDEADVMINVqGHSD 181
|
170 180 190
....*....|....*....|....*....|....*..
gi 1752084991 164 DIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAP 200
Cdd:cd18048 182 HSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
13-352 |
4.13e-18 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 86.81 E-value: 4.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEqKVQAVITAPTRELATQIHAELMK 92
Cdd:COG1205 45 LRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDP-GATALYLYPTKALARDQLRRLRE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 93 IIEKT--DIHAKLFIGGTDKQ-RsiDKLKSQPQIVVGTPgrirDLVKEQALLVHTA--------SILVVDEA-------- 153
Cdd:COG1205 124 LAEALglGVRVATYDGDTPPEeR--RWIREHPDIVLTNP----DMLHYGLLPHHTRwarffrnlRYVVIDEAhtyrgvfg 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 154 -----------DLAFDMG----FIedidqFAtqmpenlemyvfSATVPESLQpFLRKYMEAPVHIHMNDKKPVAEnIDFY 218
Cdd:COG1205 198 shvanvlrrlrRICRHYGsdpqFI-----LA------------SATIGNPAE-HAERLTGRPVTVVDEDGSPRGE-RTFV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 219 LI---PTRSKSRNTKLLEVMD-----AINPYLAIIFTNTRKQAEAVANFLSS---NGKRVGRI---HGDLTPRDRKKMMK 284
Cdd:COG1205 259 LWnppLVDDGIRRSALAEAARlladlVREGLRTLVFTRSRRGAELLARYARRalrEPDLADRVaayRAGYLPEERREIER 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752084991 285 QIRDLEFQYIVAT---DLaarGIDIPGVSHVINYELPQDLEFFIHRVGRTARAGNKGLAITLfepSDEDAI 352
Cdd:COG1205 339 GLRSGELLGVVSTnalEL---GIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLV---AGDDPL 403
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
12-398 |
5.96e-18 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 86.23 E-value: 5.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 12 FLREAIKELGFT-EPTPIQKEMI-----PLILKGKSAIGQAHTGTGKTHSFLIpIVERIKQdeqKVQAVITAPTRELATQ 85
Cdd:COG1061 67 ALEAGDEASGTSfELRPYQQEALeallaALERGGGRGLVVAPTGTGKTVLALA-LAAELLR---GKRVLVLVPRRELLEQ 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 86 IHAELMKIIEKTDIHAklfiggtdkqrsiDKLKSQPQIVVGTpgrIRDLVKEQAL--LVHTASILVVDEADLAFDMGFIE 163
Cdd:COG1061 143 WAEELRRFLGDPLAGG-------------GKKDSDAPITVAT---YQSLARRAHLdeLGDRFGLVIIDEAHHAGAPSYRR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 164 DIDQF---------AT-----QMPENLEMY---VFSATVPESL-QPFLRKYMEAPVHIHMNDKK---PVAENIDFYLIPT 222
Cdd:COG1061 207 ILEAFpaayrlgltATpfrsdGREILLFLFdgiVYEYSLKEAIeDGYLAPPEYYGIRVDLTDERaeyDALSERLREALAA 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 223 RSKSRNTKLLEVMDAINPYL-AIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAA 301
Cdd:COG1061 287 DAERKDKILRELLREHPDDRkTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLN 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 302 RGIDIPGVSHVINYELPQDLEFFIHRVGRTARAGNKGLAITLFEpsdedaivrvekmgipFVPKDIKNGEIIEMKERHAR 381
Cdd:COG1061 367 EGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYD----------------FVGNDVPVLEELAKDLRDLA 430
|
410
....*....|....*..
gi 1752084991 382 QNREKKVDEIDQIAKSR 398
Cdd:COG1061 431 GYRVEFLDEEESEELAL 447
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
4-200 |
1.37e-16 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 77.84 E-value: 1.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDYNFQPFLREAIKELGFTEPTPIQKEMIPLILKG--KSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVQAVITAPTRE 81
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 82 LATQIHaelmKIIEKT-----DIHAKLFIGGTDKQRSIdklKSQPQIVVGTPGRIRD-LVKEQALLVHTASILVVDEADL 155
Cdd:cd18047 83 LALQTG----KVIEQMgkfypELKLAYAVRGNKLERGQ---KISEQIVIGTPGTVLDwCSKLKFIDPKKIKVFVLDEADV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1752084991 156 AF-DMGFIEDIDQFATQMPENLEMYVFSATVPESLQPFLRKYMEAP 200
Cdd:cd18047 156 MIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
213-398 |
3.29e-16 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 80.57 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 213 ENIDFYLIPTRSKSRNTKLLEVMDAINPYLAIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQ-IRDlEF 291
Cdd:COG0514 203 PNLRLEVVPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRfLRD-EV 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 292 QYIVATdlAA--RGIDIPGVSHVINYELPQDLEFFIHRVGRTARAGNKGLAITLFEPSDedaIVRVEKMgipfvpkdIKN 369
Cdd:COG0514 282 DVIVAT--IAfgMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPED---VAIQRFF--------IEQ 348
|
170 180
....*....|....*....|....*....
gi 1752084991 370 GEIIEMKERHARQnrekKVDEIDQIAKSR 398
Cdd:COG0514 349 SPPDEERKRVERA----KLDAMLAYAETT 373
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
39-154 |
3.05e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 69.74 E-value: 3.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 39 GKSAIGQAHTGTGKTHSFLIPIVERIkqDEQKVQAVITAPTRELATQIHAELMKIiEKTDIHAKLFIGGTDKQRSIDKLK 118
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL--LKKGKKVLVLVPTKALALQTAERLREL-FGPGIRVAVLVGGSSAEEREKNKL 77
|
90 100 110
....*....|....*....|....*....|....*..
gi 1752084991 119 SQPQIVVGTPGRIRDLVKEQALLV-HTASILVVDEAD 154
Cdd:cd00046 78 GDADIIIATPDMLLNLLLREDRLFlKDLKLIIVDEAH 114
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
243-344 |
7.35e-14 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 68.39 E-value: 7.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 243 AIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKM-MKQIRDlEFQYIVATDLAARGIDIPGVSHVINYELPQDL 321
Cdd:cd18794 33 GIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVqRKWLRD-KIQVIVATVAFGMGIDKPDVRFVIHYSLPKSM 111
|
90 100
....*....|....*....|...
gi 1752084991 322 EFFIHRVGRTARAGNKGLAITLF 344
Cdd:cd18794 112 ESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
26-153 |
2.48e-12 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 64.98 E-value: 2.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 26 TPIQKEMI-PLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVqaVITAPTRELATQIHAELMKIIEKTDIHAKLF 104
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKA--VYIAPTRALVNQKEADLRERFGPLGKNVGLL 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1752084991 105 IGGTDKQrsiDKLKSQPQIVVGTPGRIRDLV-KEQALLVHTASILVVDEA 153
Cdd:cd17921 81 TGDPSVN---KLLLAEADILVATPEKLDLLLrNGGERLIQDVRLVVVDEA 127
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
230-337 |
1.46e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 66.29 E-value: 1.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 230 KLLEVMDAINPYL-------AIIFTNTRKQAEAVANFLSSNGKRVGRIHGD--------LTPRDRKKMMKQIRDLEFQYI 294
Cdd:COG1111 336 KLSKLREILKEQLgtnpdsrIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1752084991 295 VATDLAARGIDIPGVSHVINYEL-PQDLEfFIHRVGRTARAGNK 337
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEPvPSEIR-SIQRKGRTGRKREG 458
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
243-336 |
1.03e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 59.53 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 243 AIIFTNTRKQAEAVANFLSSNGKR---------VGRIHG------DLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIP 307
Cdd:cd18802 28 GIIFVERRATAVVLSRLLKEHPSTlafircgflIGRGNSsqrkrsLMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVP 107
|
90 100
....*....|....*....|....*....
gi 1752084991 308 GVSHVINYELPQDLEFFIHRVGRtARAGN 336
Cdd:cd18802 108 ACNLVIRFDLPKTLRSYIQSRGR-ARAPN 135
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
22-330 |
2.03e-10 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 62.81 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 22 FTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHS-FLIPIVERIKQD-----EQKVQAV-ITaPTRELATQIHAELMKII 94
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAaFLPALDELARRPrpgelPDGLRVLyIS-PLKALANDIERNLRAPL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 95 EKTDIHAKLFI---------GGT---DKQRsidKLKSQPQIVVGTPgrirdlvkEQ-ALL------------VHTasiLV 149
Cdd:COG1201 101 EEIGEAAGLPLpeirvgvrtGDTpasERQR---QRRRPPHILITTP--------ESlALLltspdarellrgVRT---VI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 150 VDE----------ADLAFDmgfIEDIDQFAtqmPENLEMYVFSATV--PESLQPFL-RKYMEAPVHI----HmnDKK--- 209
Cdd:COG1201 167 VDEihalagskrgVHLALS---LERLRALA---PRPLQRIGLSATVgpLEEVARFLvGYEDPRPVTIvdagA--GKKpdl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 210 ----PVAENIDfyLIPTRSKSrNTKLLE-VMDAINPY-LAIIFTNTRKQAEAVANFLSS-NGKRVGRI---HGDLTPRDR 279
Cdd:COG1201 239 evlvPVEDLIE--RFPWAGHL-WPHLYPrVLDLIEAHrTTLVFTNTRSQAERLFQRLNElNPEDALPIaahHGSLSREQR 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1752084991 280 KK---MMK--QIRdlefqYIVAT---DLaarGIDIPGVSHVINYELPQDLEFFIHRVGR 330
Cdd:COG1201 316 LEveeALKagELR-----AVVATsslEL---GIDIGDVDLVIQVGSPKSVARLLQRIGR 366
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
29-153 |
8.53e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 57.59 E-value: 8.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 29 QKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQkVQAVITAPTRELATQIHAELMKIIEK--TDIHAKLFIG 106
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPG-SRALYLYPTKALAQDQLRSLRELLEQlgLGIRVATYDG 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1752084991 107 GTDKQRSIDKLKSQPQIVVGTPgrirDLVkEQALL-VHTASI--------LVVDEA 153
Cdd:cd17923 84 DTPREERRAIIRNPPRILLTNP----DML-HYALLpHHDRWArflrnlryVVLDEA 134
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
243-318 |
1.05e-09 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 56.33 E-value: 1.05e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1752084991 243 AIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLE--FQYIVATDLAARGIDIPGVSHVINYELP 318
Cdd:cd18793 30 VLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPdiRVFLLSTKAGGVGLNLTAANRVILYDPW 107
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
244-343 |
1.26e-09 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 60.27 E-value: 1.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 244 IIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTpRDRKKMMKQ---------IRDLEFQYIVATDLAARGIDIPGVSHVIN 314
Cdd:PRK13766 369 IVFTQYRDTAEKIVDLLEKEGIKAVRFVGQAS-KDGDKGMSQkeqieildkFRAGEFNVLVSTSVAEEGLDIPSVDLVIF 447
|
90 100 110
....*....|....*....|....*....|
gi 1752084991 315 YE-LPQDLEfFIHRVGRTARaGNKGLAITL 343
Cdd:PRK13766 448 YEpVPSEIR-SIQRKGRTGR-QEEGRVVVL 475
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
244-348 |
1.95e-09 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 59.73 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 244 IIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQDLEF 323
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
90 100
....*....|....*....|....*
gi 1752084991 324 FIHRVGRTARAGNKGLAITLFEPSD 348
Cdd:PRK11057 320 YYQETGRAGRDGLPAEAMLFYDPAD 344
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
278-344 |
5.41e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 52.71 E-value: 5.41e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752084991 278 DRKKMMKQIRDlEFQYIVATDLAARGIDIPGVSHVINYELPQDLEFFIHRVGRTARAGNKGLAITLF 344
Cdd:cd18785 11 NSIEHAEEIAS-SLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILF 76
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
244-336 |
6.53e-09 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 54.58 E-value: 6.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 244 IIFTNTRKQAEAVA---NFLSSNGKRVGRI---HGDLTPRDRKKMMKQIRDLEFQYIVAT---DLaarGIDIPGVSHVIN 314
Cdd:cd18796 42 LVFTNTRSQAERLAqrlRELCPDRVPPDFIalhHGSLSRELREEVEAALKRGDLKVVVATsslEL---GIDIGDVDLVIQ 118
|
90 100
....*....|....*....|..
gi 1752084991 315 YELPQDLEFFIHRVGRTARAGN 336
Cdd:cd18796 119 IGSPKSVARLLQRLGRSGHRPG 140
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
232-344 |
3.41e-08 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 52.36 E-value: 3.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 232 LEVMDAINPYLAIIFTNTRKQAEAVANFLSSNGKRV----------GRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAA 301
Cdd:cd18801 22 FKKKQEGSDTRVIIFSEFRDSAEEIVNFLSKIRPGIratrfigqasGKSSKGMSQKEQKEVIEQFRKGGYNVLVATSIGE 101
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1752084991 302 RGIDIPGVSHVINYELPQDLEFFIHRVGRTARaGNKGLAITLF 344
Cdd:cd18801 102 EGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVLL 143
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
244-341 |
2.12e-07 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 49.95 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 244 IIFTNTRKQAEAVANFLSSN----GKRVGRI---HGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYE 316
Cdd:cd18797 39 IVFCRSRKLAELLLRYLKARlveeGPLASKVasyRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
|
90 100
....*....|....*....|....*
gi 1752084991 317 LPQDLEFFIHRVGRTARAGNKGLAI 341
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDSLVI 143
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
244-358 |
3.99e-07 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 52.59 E-value: 3.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 244 IIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVINYELPQDLEF 323
Cdd:PLN03137 684 IIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEG 763
|
90 100 110
....*....|....*....|....*....|....*
gi 1752084991 324 FIHRVGRTARAGNKGLAITLFEPSDedaIVRVEKM 358
Cdd:PLN03137 764 YHQECGRAGRDGQRSSCVLYYSYSD---YIRVKHM 795
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
4-90 |
1.30e-06 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 50.65 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 4 YSDY----NFQPFLREAIKElGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKT-HSFLIPIVERIKQD-----EQKVQA 73
Cdd:PRK13767 9 YSDEeildLLRPYVREWFKE-KFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFLAIIDELFRLGregelEDKVYC 87
|
90
....*....|....*..
gi 1752084991 74 VITAPTRELATQIHAEL 90
Cdd:PRK13767 88 LYVSPLRALNNDIHRNL 104
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
13-266 |
1.36e-06 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 50.59 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 13 LREAIKELGFTEPTPIQKEMIPL-ILKGKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKvqAVITAPTRELATQIHAELm 91
Cdd:PRK00254 12 IKRVLKERGIEELYPPQAEALKSgVLEGKNLVLAIPTASGKTLVAEIVMVNKLLREGGK--AVYLVPLKALAEEKYREF- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 92 KIIEKTDIHAKLFIGGTDkqrSIDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADL--AFDMGfiEDIDQFA 169
Cdd:PRK00254 89 KDWEKLGLRVAMTTGDYD---STDEWLGKYDIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLigSYDRG--ATLEMIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 170 TQMPENLEMYVFSATV--PESLQPFLRkymeapVHIHMNDKKPVA-------ENIDFYLIPTRSKSRNTKLLEVMDAINP 240
Cdd:PRK00254 164 THMLGRAQILGLSATVgnAEELAEWLN------AELVVSDWRPVKlrkgvfyQGFLFWEDGKIERFPNSWESLVYDAVKK 237
|
250 260
....*....|....*....|....*..
gi 1752084991 241 -YLAIIFTNTRKQAEAVANFLSSNGKR 266
Cdd:PRK00254 238 gKGALVFVNTRRSAEKEALELAKKIKR 264
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
45-337 |
2.16e-06 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 49.35 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 45 QAHTGTGKTHSFLIPIVERIKQdeQKVQAVITA-PTRELATQIHAELMKIIEKTDIhAKLFIGGTD-------------- 109
Cdd:cd09639 5 EAPTGYGKTEAALLWALHSLKS--QKADRVIIAlPTRATINAMYRRAKEAFGETGL-YHSSILSSRikemgdseefehlf 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 110 KQRSIDKLKS-QPQIVVGTPGRI---RDLVKEQALLVHTA---SILVVDEADL--AFDMGFIEDIDQFATQMpeNLEMYV 180
Cdd:cd09639 82 PLYIHSNDTLfLDPITVCTIDQVlksVFGEFGHYEFTLASianSLLIFDEVHFydEYTLALILAVLEVLKDN--DVPILL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 181 FSATVPESLQPFLRKyMEAPVhihmNDKKPVAENIDFYLIPTRSKSRNTKLLEVMDAINPYLA----IIFTNTRKQAEAV 256
Cdd:cd09639 160 MSATLPKFLKEYAEK-IGYVE----ENEPLDLKPNERAPFIKIESDKVGEISSLERLLEFIKKggsvAIIVNTVDRAQEF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 257 ANFLSSNGKRVGR--IHGDLTPRDRKKMMKQI----RDLEFQYIVATDLAARGIDIpGVSHVINYELPQDLefFIHRVGR 330
Cdd:cd09639 235 YQQLKEKGPEEEImlIHSRFTEKDRAKKEAELllefKKSEKFVIVATQVIEASLDI-SVDVMITELAPIDS--LIQRLGR 311
|
....*..
gi 1752084991 331 TARAGNK 337
Cdd:cd09639 312 LHRYGEK 318
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
14-152 |
3.93e-06 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 47.03 E-value: 3.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 14 REAIKELGFTePTPIQKEMIPLILKGKSA------IGQAHTGTGKTHSFLIPIVERIKQDEQkvqAVITAPTRELATQIH 87
Cdd:cd17918 6 QELCKSLPFS-LTKDQAQAIKDIEKDLHSpepmdrLLSGDVGSGKTLVALGAALLAYKNGKQ---VAILVPTEILAHQHY 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752084991 88 AELMKIIekTDIHAKLFIGGTDKQrsidkLKSQPQIVVGTPGRIRDLVKEqallvHTASILVVDE 152
Cdd:cd17918 82 EEARKFL--PFINVELVTGGTKAQ-----ILSGISLLVGTHALLHLDVKF-----KNLDLVIVDE 134
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
243-309 |
4.65e-06 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 45.24 E-value: 4.65e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 243 AIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQI---RDLEFQYIVATDLAARGIDIPGV 309
Cdd:cd18799 9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGDEALILlffGELKPPILVTVDLLTTGVDIPEV 78
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
227-318 |
5.91e-06 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 48.68 E-value: 5.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 227 RNTKLLEVMDAINPYLA-----IIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIR-DLEF-QYIVATDL 299
Cdd:COG0553 531 RSAKLEALLELLEELLAegekvLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQeGPEApVFLISLKA 610
|
90
....*....|....*....
gi 1752084991 300 AARGIDIPGVSHVINYELP 318
Cdd:COG0553 611 GGEGLNLTAADHVIHYDLW 629
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
27-153 |
1.67e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 44.60 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 27 PIQKEMIPLILK---GKSAIGQAHTGTGKTHSFLIPIVERIkqdEQKVqaVITAPTRELATQIHAElmkIIEKTDIHAKL 103
Cdd:cd17926 3 PYQEEALEAWLAhknNRRGILVLPTGSGKTLTALALIAYLK---ELRT--LIVVPTDALLDQWKER---FEDFLGDSSIG 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1752084991 104 FIGGTDKQRSIDKlksqpQIVVGTPGRIRDLVKEQALLVHTASILVVDEA 153
Cdd:cd17926 75 LIGGGKKKDFDDA-----NVVVATYQSLSNLAEEEKDLFDQFGLLIVDEA 119
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
226-307 |
4.05e-05 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 43.70 E-value: 4.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 226 SRNTKLLEVMDAINPYL-AIIFTNTRKQAEAVANFLSsnGkrVGRIHGDLTPRDRKKmmkqIRDLeF-----QYIVATD- 298
Cdd:cd18795 28 DSDIIVLLKIETVSEGKpVLVFCSSRKECEKTAKDLA--G--IAFHHAGLTREDREL----VEEL-FregliKVLVATSt 98
|
....*....
gi 1752084991 299 LAArGIDIP 307
Cdd:cd18795 99 LAA-GVNLP 106
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
39-152 |
4.60e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 43.73 E-value: 4.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 39 GKSAIGQAHTGTGKTHSFLIPIVERI-KQDEQKVQAVITAPTRELATQIHAELMKIIE--KTDIHAKLFIGGTDKQRSID 115
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLaDEPEKGVQVLYISPLKALINDQERRLEEPLDeiDLEIPVAVRHGDTSQSEKAK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1752084991 116 KLKSQPQIVVGTPgrirdlvkE--QALLVHTA--------SILVVDE 152
Cdd:cd17922 81 QLKNPPGILITTP--------EslELLLVNKKlrelfaglRYVVVDE 119
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
243-341 |
5.29e-05 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 43.39 E-value: 5.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 243 AIIFTNTRKQAEAVANFLSSNGKRVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVInyELPQDLE 322
Cdd:cd18790 30 VLVTTLTKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVA--ILDADKE 107
|
90 100
....*....|....*....|....*.
gi 1752084991 323 FF-------IHRVGRTARAGNkGLAI 341
Cdd:cd18790 108 GFlrsetslIQTIGRAARNVN-GKVI 132
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
9-154 |
7.96e-05 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 43.47 E-value: 7.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 9 FQPFLREAIKelgfTEPTPIQKEMIPLILKGKSAIGQAHTGTGKThSFLIPIVERIKQDEQKVQAVItaPTRELATQIHA 88
Cdd:cd17924 6 FEEFFKKKTG----FPPWGAQRTWAKRLLRGKSFAIIAPTGVGKT-TFGLATSLYLASKGKRSYLIF--PTKSLVKQAYE 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752084991 89 ELMKIIEKTDIHAKLFI--GGTDKQRSIDKLKSQPQ----IVVGTPGRIRDLVKEqaLLVHTASILVVDEAD 154
Cdd:cd17924 79 RLSKYAEKAGVEVKILVyhSRLKKKEKEELLEKIEKgdfdILVTTNQFLSKNFDL--LSNKKFDFVFVDDVD 148
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
10-152 |
1.19e-04 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 43.29 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 10 QPFLREAIKELGFtEPTPIQKEMIPLILKGKSAIGQAH------TGTGKT----HSFLIPIverikqdEQKVQAVITAPT 79
Cdd:cd17992 32 GELLKKFLEALPF-ELTGAQKRVIDEILRDLASEKPMNrllqgdVGSGKTvvaaLAMLAAV-------ENGYQVALMAPT 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752084991 80 RELATQIHAELMKIIEKTDIHAKLFIG---GTDKQRSIDKLKS-QPQIVVGTPGRIRDLVKEQALlvhtaSILVVDE 152
Cdd:cd17992 104 EILAEQHYDSLKKLLEPLGIRVALLTGstkAKEKREILEKIASgEIDIVIGTHALIQEDVEFHNL-----GLVIIDE 175
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
266-356 |
1.11e-03 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 39.25 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 266 RVGRIHGDLTPRDRKKMMKQIRDLEFQYIVATDLAARGIDIPGVSHVI-----NYELPQdleffIHRV-GRTARAGNKGL 339
Cdd:cd18810 53 RIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIieradKFGLAQ-----LYQLrGRVGRSKERAY 127
|
90 100
....*....|....*....|
gi 1752084991 340 AITLFEPS---DEDAIVRVE 356
Cdd:cd18810 128 AYFLYPDQkklTEDALKRLE 147
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
27-186 |
1.29e-03 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 39.62 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 27 PIQKEMI-PLILKGKSAIGQAHTGTGKThsfLIPIVERIKQDEQKVQAVITAPTRELATQIHAELmKIIEKTDIHAKLFI 105
Cdd:cd18028 4 PPQAEAVrAGLLKGENLLISIPTASGKT---LIAEMAMVNTLLEGGKALYLVPLRALASEKYEEF-KKLEEIGLKVGIST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 106 GGTDKQrsiDKLKSQPQIVVGTPGRIRDLVKEQALLVHTASILVVDEADLAFDM---GFIEDIDQFATQMPENLEMYVFS 182
Cdd:cd18028 80 GDYDED---DEWLGDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEergPTLESIVARLRRLNPNTQIIGLS 156
|
....
gi 1752084991 183 ATVP 186
Cdd:cd18028 157 ATIG 160
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
48-153 |
1.42e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 39.19 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 48 TGTGKTHSFLIpIVERIKQDEQKVQAVITAPTRELATQIHAELMKIIEKTDIHAKLFIGGTDKQRSIDKlksqpQIVVGT 127
Cdd:pfam04851 32 TGSGKTLTAAK-LIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKDESVDDN-----KIVVTT 105
|
90 100
....*....|....*....|....*....
gi 1752084991 128 P---GRIRDLVKEQaLLVHTASILVVDEA 153
Cdd:pfam04851 106 IqslYKALELASLE-LLPDFFDVIIIDEA 133
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
20-153 |
2.53e-03 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 38.78 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 20 LGFTEPTPIQKEMIPLILKGKSAIGQAHTGTGKTHSFLIPIVerIKQDEQKVQAVITAPTREL-ATQIHAeLMKIIEKTD 98
Cdd:cd18018 8 FGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL--LLRRRGPGLTLVVSPLIALmKDQVDA-LPRAIKAAA 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1752084991 99 IHAKLfiGGTDKQRSIDKLKS-QPQIVVGTPGRIRDL-VKEQALLVHTASILVVDEA 153
Cdd:cd18018 85 LNSSL--TREERRRILEKLRAgEVKILYVSPERLVNEsFRELLRQTPPISLLVVDEA 139
|
|
| PRK07246 |
PRK07246 |
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated |
45-101 |
2.86e-03 |
|
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Pssm-ID: 180905 [Multi-domain] Cd Length: 820 Bit Score: 40.06 E-value: 2.86e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 45 QAHTGTGKTHSFLIPIVERIKQDeqkvQAVITAPTRELATQIHAELMKIIEK---TDIHA 101
Cdd:PRK07246 270 EAQTGIGKTYGYLLPLLAQSDQR----QIIVSVPTKILQDQIMAEEVKAIQEvfhIDCHS 325
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
29-86 |
8.47e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 38.37 E-value: 8.47e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752084991 29 QKEMIPLILK----GKSAIGQAHTGTGKTHSFLIPIVERIKQDEQKVqaVITAPTRELATQI 86
Cdd:COG1199 19 QREMAEAVARalaeGRHLLIEAGTGTGKTLAYLVPALLAARETGKKV--VISTATKALQEQL 78
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
72-152 |
9.49e-03 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 38.21 E-value: 9.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752084991 72 QAVITAPTRELATQIHAELMKIIEKTDIHAKLFIGGT---DKQRSIDKLKS-QPQIVVGTPGRIRDLVKEQAL-LVhtas 146
Cdd:PRK10917 312 QAALMAPTEILAEQHYENLKKLLEPLGIRVALLTGSLkgkERREILEAIASgEADIVIGTHALIQDDVEFHNLgLV---- 387
|
....*.
gi 1752084991 147 ilVVDE 152
Cdd:PRK10917 388 --IIDE 391
|
|
| |
