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Conserved domains on  [gi|1750417370|ref|WP_150013781|]
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MULTISPECIES: GNAT family N-acetyltransferase [Pantoea]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 15202679)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  27367672|26818562|15581578|10940244|9175471
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_18 super family cl40257
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 154-270 3.44e-18

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


The actual alignment was detected with superfamily member pfam18014:

Pssm-ID: 436212  Cd Length: 123  Bit Score: 78.48  E-value: 3.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370 154 VTLDQQAHGMHRPALIEHLLRDC-QTVILEDAQQQIQGFASLRRFGHGWAIGPVIAADFPAAQALVASLMQSLQGEfLRI 232
Cdd:pfam18014   2 LELDREAFGADRSAFLKRRLKQAdQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGP-VRI 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1750417370 233 DTDAALPMA-AWLESLGIPQVDAPTTMVRGTPWTPQGMQ 270
Cdd:pfam18014  81 DVPEENPALiALLESLGFEKVFECPRMVKGGPPLPERNE 119
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-123 3.73e-16

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.58  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   5 IRAMTPDDIETCFTLTQvLNWPHRRE-----DWQLALQLGEGTVIEEQGKLIGSAVLWRW----GDRAATVGLVIIDNQQ 75
Cdd:COG3153     1 IRPATPEDAEAIAALLR-AAFGPGREaelvdRLREDPAAGLSLVAEDDGEIVGHVALSPVdidgEGPALLLGPLAVDPEY 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1750417370  76 QGRGLGKQLMLAQLEKLPDYN---VRLHATEMGKGLYEKLGFVSCGEIRQH 123
Cdd:COG3153    80 RGQGIGRALMRAALEAARERGaraVVLLGDPSLLPFYERFGFRPAGELGLT 130
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 154-270 3.44e-18

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 78.48  E-value: 3.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370 154 VTLDQQAHGMHRPALIEHLLRDC-QTVILEDAQQQIQGFASLRRFGHGWAIGPVIAADFPAAQALVASLMQSLQGEfLRI 232
Cdd:pfam18014   2 LELDREAFGADRSAFLKRRLKQAdQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGP-VRI 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1750417370 233 DTDAALPMA-AWLESLGIPQVDAPTTMVRGTPWTPQGMQ 270
Cdd:pfam18014  81 DVPEENPALiALLESLGFEKVFECPRMVKGGPPLPERNE 119
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-123 3.73e-16

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.58  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   5 IRAMTPDDIETCFTLTQvLNWPHRRE-----DWQLALQLGEGTVIEEQGKLIGSAVLWRW----GDRAATVGLVIIDNQQ 75
Cdd:COG3153     1 IRPATPEDAEAIAALLR-AAFGPGREaelvdRLREDPAAGLSLVAEDDGEIVGHVALSPVdidgEGPALLLGPLAVDPEY 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1750417370  76 QGRGLGKQLMLAQLEKLPDYN---VRLHATEMGKGLYEKLGFVSCGEIRQH 123
Cdd:COG3153    80 RGQGIGRALMRAALEAARERGaraVVLLGDPSLLPFYERFGFRPAGELGLT 130
Eis COG4552
Predicted acetyltransferase [General function prediction only];
3-260 2.19e-14

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 72.24  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   3 LTIRAMTPDDIETCFTL-TQVLNWPHRREDWQLA---LQLGEGTVIEEQGKLIGSAVLWR----WGDR---AATVGLVII 71
Cdd:COG4552     1 MEIRPLTEDDLDAFARLlAYAFGPEPDDEELEAYrplLEPGRVLGVFDDGELVGTLALYPftlnVGGArvpMAGITGVAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  72 DNQQQGRGLGKQLMLAQLEKLPDYNVR---LHATEMgkGLYEKLGFVSCGEIRQHQ--TRALTTLPevviPAGLKLRPAT 146
Cdd:COG4552    81 APEHRRRGVARALLREALAELRERGQPlsaLYPFEP--GFYRRFGYELAGDRRRYTipPESLPLRP----DAPGRVRRVD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370 147 AADHGTLVTLDQQA----HGMHR--PALIEHLLRDC-----QTVILEDAQQQIQGFASLRRFGHGWA----IGPVIAADF 211
Cdd:COG4552   155 PDDAELLAALYERFarrrPGALDrdEAWWERVLRDLggeplRAAVHYDEDGEPDGYVLYRVKDGGDGgtleVRELVALTP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1750417370 212 PAAQALVASL-MQSLQGEFLRIDTDAALPMAAWL-ESLGIPQVDAPTTMVR 260
Cdd:COG4552   235 EARRALWRFLaSHDSQVDRVRWRLPVDDPLPLLLpDPRAAKTTIRPGLMLR 285
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-115 1.02e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 57.08  E-value: 1.02e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750417370  43 VIEEQGKLIGSAVLWRWGDRAATVGL-VIIDNQQQGRGLGKQLM---LAQLEKLPDYNVRLHATEMGKGLYEKLGFV 115
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAELrLAVHPEYRGQGIGRALLeaaEAAAKEGGIKLLELETTNRAAAFYEKLGFE 83
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-100 1.49e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 1.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750417370  43 VIEEQGKLIGSAVLWRWG--DRAATVGLVIIDNQQQGRGLGKQLM---LAQLEKLPDYNVRLH 100
Cdd:cd04301     3 VAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLeaaEEEARERGAKRLRLE 65
PRK07757 PRK07757
N-acetyltransferase;
42-114 4.63e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 36.71  E-value: 4.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1750417370  42 TVIEEQGKLIGSAVLWRWGDRAATVGLVIIDNQQQGRGLGKQLMLAQLEKLPDYNV-RLHATEMGKGLYEKLGF 114
Cdd:PRK07757   44 YVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVkRVFALTYQPEFFEKLGF 117
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 43-121 5.71e-03

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 36.15  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  43 VIEEQGKLIGSAVLWR-WGDraATVGLVIIDNQQQGRGLGKQLmlaqLEKLPDYNVRLHATEM----------GKGLYEK 111
Cdd:TIGR01575  35 LARIGGKVVGYAGVQIvLDE--AHILNIAVKPEYQGQGIGRAL----LRELIDEAKGRGVNEIflevrvsniaAQALYKK 108

                          90
                  ....*....|
gi 1750417370 112 LGFVSCGEIR 121
Cdd:TIGR01575 109 LGFNEIAIRR 118
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 154-270 3.44e-18

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 78.48  E-value: 3.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370 154 VTLDQQAHGMHRPALIEHLLRDC-QTVILEDAQQQIQGFASLRRFGHGWAIGPVIAADFPAAQALVASLMQSLQGEfLRI 232
Cdd:pfam18014   2 LELDREAFGADRSAFLKRRLKQAdQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGP-VRI 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1750417370 233 DTDAALPMA-AWLESLGIPQVDAPTTMVRGTPWTPQGMQ 270
Cdd:pfam18014  81 DVPEENPALiALLESLGFEKVFECPRMVKGGPPLPERNE 119
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-123 3.73e-16

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.58  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   5 IRAMTPDDIETCFTLTQvLNWPHRRE-----DWQLALQLGEGTVIEEQGKLIGSAVLWRW----GDRAATVGLVIIDNQQ 75
Cdd:COG3153     1 IRPATPEDAEAIAALLR-AAFGPGREaelvdRLREDPAAGLSLVAEDDGEIVGHVALSPVdidgEGPALLLGPLAVDPEY 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1750417370  76 QGRGLGKQLMLAQLEKLPDYN---VRLHATEMGKGLYEKLGFVSCGEIRQH 123
Cdd:COG3153    80 RGQGIGRALMRAALEAARERGaraVVLLGDPSLLPFYERFGFRPAGELGLT 130
Eis COG4552
Predicted acetyltransferase [General function prediction only];
3-260 2.19e-14

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 72.24  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   3 LTIRAMTPDDIETCFTL-TQVLNWPHRREDWQLA---LQLGEGTVIEEQGKLIGSAVLWR----WGDR---AATVGLVII 71
Cdd:COG4552     1 MEIRPLTEDDLDAFARLlAYAFGPEPDDEELEAYrplLEPGRVLGVFDDGELVGTLALYPftlnVGGArvpMAGITGVAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  72 DNQQQGRGLGKQLMLAQLEKLPDYNVR---LHATEMgkGLYEKLGFVSCGEIRQHQ--TRALTTLPevviPAGLKLRPAT 146
Cdd:COG4552    81 APEHRRRGVARALLREALAELRERGQPlsaLYPFEP--GFYRRFGYELAGDRRRYTipPESLPLRP----DAPGRVRRVD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370 147 AADHGTLVTLDQQA----HGMHR--PALIEHLLRDC-----QTVILEDAQQQIQGFASLRRFGHGWA----IGPVIAADF 211
Cdd:COG4552   155 PDDAELLAALYERFarrrPGALDrdEAWWERVLRDLggeplRAAVHYDEDGEPDGYVLYRVKDGGDGgtleVRELVALTP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1750417370 212 PAAQALVASL-MQSLQGEFLRIDTDAALPMAAWL-ESLGIPQVDAPTTMVR 260
Cdd:COG4552   235 EARRALWRFLaSHDSQVDRVRWRLPVDDPLPLLLpDPRAAKTTIRPGLMLR 285
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 3-119 6.85e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 61.55  E-value: 6.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   3 LTIRAMTPDDIETCFTLtqvlnwphrREDWQLALQLGEGTVIEEQGKLIGSAVLWRWGDRAATVGLVIIDNQQQGRGLGK 82
Cdd:COG1246     1 MTIRPATPDDVPAILEL---------IRPYALEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGR 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1750417370  83 QLM---LAQLEKLPDYNVRLHATEMGKGLYEKLGFVSCGE 119
Cdd:COG1246    72 RLLealLAEARELGLKRLFLLTTSAAIHFYEKLGFEEIDK 111
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
43-120 8.60e-12

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 61.35  E-value: 8.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  43 VIEEQGKLIGSAVLWRWGDRAATVGLVIIDNQQQGRGLGKQLM---LAQLEKLPDYNVRLHATEMGKGLYEKLGFVSCGE 119
Cdd:COG2153    38 LAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMeaaIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGE 117


                  .
gi 1750417370 120 I 120
Cdd:COG2153   118 E 118
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-115 1.02e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 57.08  E-value: 1.02e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750417370  43 VIEEQGKLIGSAVLWRWGDRAATVGL-VIIDNQQQGRGLGKQLM---LAQLEKLPDYNVRLHATEMGKGLYEKLGFV 115
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAELrLAVHPEYRGQGIGRALLeaaEAAAKEGGIKLLELETTNRAAAFYEKLGFE 83
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-135 2.18e-10

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 58.08  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   2 SLTIRAMTPDDI------------ETCFTLTQVLNWPHRREDWqLALQLGEGT---VIEEQGKLIGSAVLWRWGDRAATV 66
Cdd:COG1247     1 EMTIRPATPEDApaiaaiyneaiaEGTATFETEPPSEEEREAW-FAAILAPGRpvlVAEEDGEVVGFASLGPFRPRPAYR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1750417370  67 GL----VIIDNQQQGRGLGKQLMLAQLEKLPDYNVR-LHAT-----EMGKGLYEKLGFVSCGEIRQHQTRALTTLPEVV 135
Cdd:COG1247    80 GTaeesIYVDPDARGRGIGRALLEALIERARARGYRrLVAVvladnEASIALYEKLGFEEVGTLPEVGFKFGRWLDLVL 158
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 3-115 3.00e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 48.51  E-value: 3.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   3 LTIRAMTPDDIEtcftltqvLNWPHRREDWQLALQLGEGT-----VIEEQGKLIGSAVLWRWGDRAATVGLVIIDNQQQG 77
Cdd:COG0454     1 MSIRKATPEDIN--------FILLIEALDAELKAMEGSLAgaefiAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRG 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1750417370  78 RGLGKQLmlaqLEKLPDYNVRLHATEM----------GKGLYEKLGFV 115
Cdd:COG0454    73 KGIGKAL----LEALLEWARERGCTALeldtldgnpaAIRFYERLGFK 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 45-122 8.11e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 47.27  E-value: 8.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  45 EEQGKLIGSAVLwrwgDRAATVGLVIIDNQQQGRGLGKQLMLAQLEKLPDYNVRLHATEM-----GKGLYEKLGFVSCGE 119
Cdd:pfam13673  37 FEGGQIVGVIAL----RDRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVnaspyAVPFYEKLGFRATGP 112


                  ...
gi 1750417370 120 IRQ 122
Cdd:pfam13673 113 EQE 115
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 3-123 1.33e-06

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 47.30  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   3 LTIRAMTPDDIETCFTL-------TQVLNWPHRREDWQ-----LALQLGEGT------VIEEQGKLIGSAVLWR--WGDR 62
Cdd:COG1670     8 LRLRPLRPEDAEALAELlndpevaRYLPGPPYSLEEARawlerLLADWADGGalpfaiEDKEDGELIGVVGLYDidRANR 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750417370  63 AATVGlVIIDNQQQGRGLGKQLMLAqlekLPDY---NVRLHATEMG--------KGLYEKLGFVSCGEIRQH 123
Cdd:COG1670    88 SAEIG-YWLAPAYWGKGYATEALRA----LLDYafeELGLHRVEAEvdpdntasIRVLEKLGFRLEGTLRDA 154
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 5-114 1.99e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 46.02  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   5 IRAMTPDDIETCFTL-TQVLNW---PHRREDWQLALQLGEGTVIEEQGKLIGSAVL----WRWGD---RAATVGLVIIDN 73
Cdd:pfam13527   1 IRPLTEDEFDEVLRLlEYAFQDedsPELREYFRPLLEEGRVLGAFDDGELVSTLALypfeLNVPGktlPAAGITGVATYP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1750417370  74 QQQGRGLGKQLMLAQLEKLPDYNVR---LHATEMgkGLYEKLGF 114
Cdd:pfam13527  81 EYRGRGVMSRLLRRSLEEMRERGVPlsfLYPSSY--PIYRRFGY 122
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 26-114 2.12e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 45.59  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  26 PHRREDWQLALQLGEGTVIEEQGKLIGSAVLWRWGDRAATVGL--VIIDNQQQGRGLGKQLMLAQLEKLPDYNVRLHATE 103
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIegLAVAPEYRGKGIGTALLQALLEWARERGCERIFLE 99

                          90
                  ....*....|....*..
gi 1750417370 104 MGK------GLYEKLGF 114
Cdd:pfam00583 100 VAAdnlaaiALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 52-123 5.85e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 43.88  E-value: 5.85e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1750417370  52 GSAVLWR-WGDRAATVGLVIIDNQQQGRGLGKQLMLAQLEKLPDYN---VRLHATE---MGKGLYEKLGFVSCGEIRQH 123
Cdd:COG0456     1 GFALLGLvDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREdneAAIALYEKLGFEEVGERPNY 79
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
49-121 2.42e-05

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 41.82  E-value: 2.42e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1750417370  49 KLIGSAVLWRWGDRAATVGLVIIDNQQQGRGLGKQLMLAQLEKLPDYNVR---LH---ATEMGKGLYEKLGFVSCGEIR 121
Cdd:COG3393     1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARtpfLYvdaDNPAARRLYERLGFRPVGEYA 79
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-100 1.49e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 1.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750417370  43 VIEEQGKLIGSAVLWRWG--DRAATVGLVIIDNQQQGRGLGKQLM---LAQLEKLPDYNVRLH 100
Cdd:cd04301     3 VAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLeaaEEEARERGAKRLRLE 65
PRK07757 PRK07757
N-acetyltransferase;
42-114 4.63e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 36.71  E-value: 4.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1750417370  42 TVIEEQGKLIGSAVLWRWGDRAATVGLVIIDNQQQGRGLGKQLMLAQLEKLPDYNV-RLHATEMGKGLYEKLGF 114
Cdd:PRK07757   44 YVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVkRVFALTYQPEFFEKLGF 117
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 43-121 5.71e-03

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 36.15  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  43 VIEEQGKLIGSAVLWR-WGDraATVGLVIIDNQQQGRGLGKQLmlaqLEKLPDYNVRLHATEM----------GKGLYEK 111
Cdd:TIGR01575  35 LARIGGKVVGYAGVQIvLDE--AHILNIAVKPEYQGQGIGRAL----LRELIDEAKGRGVNEIflevrvsniaAQALYKK 108

                          90
                  ....*....|
gi 1750417370 112 LGFVSCGEIR 121
Cdd:TIGR01575 109 LGFNEIAIRR 118
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 3-115 9.68e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 35.78  E-value: 9.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370   3 LTIRAMTPDDIETCFTLTQ-------VLNWPHRRED--------WQLALQL-GEG-TVIEEQGKLIGSAVLWR--WGDRA 63
Cdd:pfam13302   2 LLLRPLTEEDAEALFELLSdpevmryGVPWPLTLEEarewlariWAADEAErGYGwAIELKDTGFIGSIGLYDidGEPER 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750417370  64 ATVGLvIIDNQQQGRGLG---KQLMLAQLEKLPDYNvRLHAT-----EMGKGLYEKLGFV 115
Cdd:pfam13302  82 AELGY-WLGPDYWGKGYAteaVRALLEYAFEELGLP-RLVARidpenTASRRVLEKLGFK 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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