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Conserved domains on  [gi|1720808547|ref|WP_146049062|]
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IMP dehydrogenase, partial [Petrotoga sibirica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IMPDH super family cl37991
IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine ...
 5-70 3.08e-41

IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.


The actual alignment was detected with superfamily member pfam00478:

Pssm-ID: 459826 [Multi-domain]  Cd Length: 463  Bit Score: 139.06  E-value: 3.08e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:pfam00478   2 LTFDDVLLVPGYSEVLPREVDLSTRLTRNITLNIPLVSAAMDTVTEARMAIAMAREGGIGIIHKNM 67
 
Name Accession Description Interval E-value
IMPDH pfam00478
IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine ...
 5-70 3.08e-41

IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.


Pssm-ID: 459826 [Multi-domain]  Cd Length: 463  Bit Score: 139.06  E-value: 3.08e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:pfam00478   2 LTFDDVLLVPGYSEVLPREVDLSTRLTRNITLNIPLVSAAMDTVTEARMAIAMAREGGIGIIHKNM 67
IMPDH cd00381
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the ...
 5-70 5.80e-36

IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine nucleotides. There is often a CBS domain inserted in the middle of this domain, which is proposed to play a regulatory role. IMPDH is a key enzyme in the regulation of cell proliferation and differentiation. It has been identified as an attractive target for developing chemotherapeutic agents.


Pssm-ID: 238223 [Multi-domain]  Cd Length: 325  Bit Score: 122.63  E-value: 5.80e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:cd00381     2 LTFDDVLLVPGYSTVLPSEVDLSTKLTKNITLNIPLVSAPMDTVTESEMAIAMARLGGIGVIHRNM 67
IMP_dehydrog TIGR01302
inosine-5'-monophosphate dehydrogenase; This model describes IMP dehydrogenase, an enzyme of ...
 5-70 2.51e-33

inosine-5'-monophosphate dehydrogenase; This model describes IMP dehydrogenase, an enzyme of GMP biosynthesis. This form contains two CBS domains. This model describes a rather tightly conserved cluster of IMP dehydrogenase sequences, many of which are characterized. The model excludes two related families of proteins proposed also to be IMP dehydrogenases, but without characterized members. These are related families are the subject of separate models. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273546 [Multi-domain]  Cd Length: 450  Bit Score: 117.83  E-value: 2.51e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:TIGR01302   2 LTFDDVLLLPGFIDVEPDDVDLSTRITRNIKLNIPILSSPMDTVTESRMAIAMAREGGIGVIHRNM 67
PTZ00314 PTZ00314
inosine-5'-monophosphate dehydrogenase; Provisional
 5-70 3.69e-30

inosine-5'-monophosphate dehydrogenase; Provisional


Pssm-ID: 240355 [Multi-domain]  Cd Length: 495  Bit Score: 109.67  E-value: 3.69e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:PTZ00314   18 LTYDDVILLPGYIDFSRDDVDLSTRLTRNIRLKIPIVSSPMDTVTEHKMAIAMALMGGIGVIHNNC 83
GuaB COG0516
IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; IMP dehydrogenase/GMP ...
 5-70 1.97e-17

IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; IMP dehydrogenase/GMP reductase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 440282 [Multi-domain]  Cd Length: 326  Bit Score: 73.70  E-value: 1.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720808547   5 LTFDDVLLLPQYS---EVVPNKVDTTSRLVK-------------NIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHK 68
Cdd:COG0516   132 LTFDDVLLIPGNSatvEPARALVDAGADLTKvgigpgsicttrvVIGLGIPQLSAAMDTVTEARMAIAIAADGGIGYIHD 211


                  ..
gi 1720808547  69 NM 70
Cdd:COG0516   212 NA 213
 
Name Accession Description Interval E-value
IMPDH pfam00478
IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine ...
 5-70 3.08e-41

IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.


Pssm-ID: 459826 [Multi-domain]  Cd Length: 463  Bit Score: 139.06  E-value: 3.08e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:pfam00478   2 LTFDDVLLVPGYSEVLPREVDLSTRLTRNITLNIPLVSAAMDTVTEARMAIAMAREGGIGIIHKNM 67
IMPDH cd00381
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the ...
 5-70 5.80e-36

IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine nucleotides. There is often a CBS domain inserted in the middle of this domain, which is proposed to play a regulatory role. IMPDH is a key enzyme in the regulation of cell proliferation and differentiation. It has been identified as an attractive target for developing chemotherapeutic agents.


Pssm-ID: 238223 [Multi-domain]  Cd Length: 325  Bit Score: 122.63  E-value: 5.80e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:cd00381     2 LTFDDVLLVPGYSTVLPSEVDLSTKLTKNITLNIPLVSAPMDTVTESEMAIAMARLGGIGVIHRNM 67
IMP_dehydrog TIGR01302
inosine-5'-monophosphate dehydrogenase; This model describes IMP dehydrogenase, an enzyme of ...
 5-70 2.51e-33

inosine-5'-monophosphate dehydrogenase; This model describes IMP dehydrogenase, an enzyme of GMP biosynthesis. This form contains two CBS domains. This model describes a rather tightly conserved cluster of IMP dehydrogenase sequences, many of which are characterized. The model excludes two related families of proteins proposed also to be IMP dehydrogenases, but without characterized members. These are related families are the subject of separate models. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273546 [Multi-domain]  Cd Length: 450  Bit Score: 117.83  E-value: 2.51e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:TIGR01302   2 LTFDDVLLLPGFIDVEPDDVDLSTRITRNIKLNIPILSSPMDTVTESRMAIAMAREGGIGVIHRNM 67
PTZ00314 PTZ00314
inosine-5'-monophosphate dehydrogenase; Provisional
 5-70 3.69e-30

inosine-5'-monophosphate dehydrogenase; Provisional


Pssm-ID: 240355 [Multi-domain]  Cd Length: 495  Bit Score: 109.67  E-value: 3.69e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:PTZ00314   18 LTYDDVILLPGYIDFSRDDVDLSTRLTRNIRLKIPIVSSPMDTVTEHKMAIAMALMGGIGVIHNNC 83
PRK06843 PRK06843
inosine 5-monophosphate dehydrogenase; Validated
 1-70 1.00e-27

inosine 5-monophosphate dehydrogenase; Validated


Pssm-ID: 180725 [Multi-domain]  Cd Length: 404  Bit Score: 102.42  E-value: 1.00e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720808547   1 MEEYLTFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:PRK06843    6 TKEALTFDDVSLIPRKSSVLPSEVSLKTQLTKNISLNIPFLSSAMDTVTESQMAIAIAKEGGIGIIHKNM 75
PLN02274 PLN02274
inosine-5'-monophosphate dehydrogenase
 6-70 4.15e-22

inosine-5'-monophosphate dehydrogenase


Pssm-ID: 215154 [Multi-domain]  Cd Length: 505  Bit Score: 87.42  E-value: 4.15e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720808547   6 TFDDVLLLPQYSEVVPNKVDTTSRLVKNIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHKNM 70
Cdd:PLN02274   23 TYDDVIFHPGYIDFPADAVDLSTRLSRNIPLSIPCVSSPMDTVTESDMAIAMAALGGIGIVHYNN 87
GuaB COG0516
IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; IMP dehydrogenase/GMP ...
 5-70 1.97e-17

IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; IMP dehydrogenase/GMP reductase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 440282 [Multi-domain]  Cd Length: 326  Bit Score: 73.70  E-value: 1.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720808547   5 LTFDDVLLLPQYS---EVVPNKVDTTSRLVK-------------NIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVIHK 68
Cdd:COG0516   132 LTFDDVLLIPGNSatvEPARALVDAGADLTKvgigpgsicttrvVIGLGIPQLSAAMDTVTEARMAIAIAADGGIGYIHD 211


                  ..
gi 1720808547  69 NM 70
Cdd:COG0516   212 NA 213
PRK07107 PRK07107
IMP dehydrogenase;
2-66 1.45e-12

IMP dehydrogenase;


Pssm-ID: 180842 [Multi-domain]  Cd Length: 502  Bit Score: 60.48  E-value: 1.45e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720808547   2 EEYLTFDDVLLLPQYS--EVVPNKVDTTSRLVK-------NIHLKIPFLSAAMDTVSESQMAKAMAREGAVGVI 66
Cdd:PRK07107    7 EPSRTFSEYLLVPGLSskECVPANVSLKTPLVKfkkgeesAITLNIPLVSAIMQSVSDDNMAIALAREGGLSFI 80
PRK07807 PRK07807
GuaB1 family IMP dehydrogenase-related protein;
5-66 1.47e-07

GuaB1 family IMP dehydrogenase-related protein;


Pssm-ID: 181127 [Multi-domain]  Cd Length: 479  Bit Score: 46.05  E-value: 1.47e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720808547   5 LTFDDVLLLPQYSEVvpnkvdtTSRLvkNIHLK--------IPFLSAAMDTVSESQMAKAMAREGAVGVI 66
Cdd:PRK07807   13 LTYDDVFLVPSRSDV-------GSRF--DVDLStadgtgttIPLVVANMTAVAGRRMAETVARRGGLVVL 73
PRK05096 PRK05096
guanosine 5'-monophosphate oxidoreductase; Provisional
 5-68 1.30e-04

guanosine 5'-monophosphate oxidoreductase; Provisional


Pssm-ID: 235343 [Multi-domain]  Cd Length: 346  Bit Score: 37.61  E-value: 1.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720808547   5 LTFDDVLLLPQYSEVvpnkvdtTSR----LVKNIHLK--------IPFLSAAMDTVSESQMAKAMAREGAVGVIHK 68
Cdd:PRK05096    9 LGFKDVLIRPKRSTL-------KSRsdveLERQFTFKhsgqswsgVPIIAANMDTVGTFEMAKALASFDILTAVHK 77
YrpB COG2070
NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family [General ...
 36-66 8.83e-03

NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family [General function prediction only];


Pssm-ID: 441673 [Multi-domain]  Cd Length: 302  Bit Score: 32.39  E-value: 8.83e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720808547  36 LKIPFLSAAMDTVSESQMAKAMAREGAVGVI 66
Cdd:COG2070     3 IRYPIIQGPMAGVSTPELAAAVSNAGGLGSI 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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