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Conserved domains on  [gi|1690924632|ref|WP_139618453|]
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helix-turn-helix domain-containing protein, partial [Escherichia coli]

Protein Classification

transposase( domain architecture ID 12146481)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0006313|GO:0003677|GO:0004803
PubMed:  20885819|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
54-156 1.12e-09

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


:

Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 52.23  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690924632  54 RHKRSYSPEDKLCVVLYALGHSESLPRVAARFNIpSHNTVKNWIKGYRKSGNEAFirrrkeksmtrSDDTHENEANMTPE 133
Cdd:COG2963     3 KKRRRYSPEFKAEAVRLVLEGGASVAEVARELGI-SPSTLYRWVRQYREGGLGGF-----------PGDGRTTPEQAEIR 70

                          90       100
                  ....*....|....*....|...
gi 1690924632 134 EMKNELRYLRAENAYLKAMQEHL 156
Cdd:COG2963    71 RLRKELRRLEMENDILKKAAALL 93
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 7-57 4.85e-04

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


:

Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 36.42  E-value: 4.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1690924632   7 VKLAAVNHYLAGHaGIISTAKLFQLSHTSLSHWINLFLLHGPRALDCRHKR 57
Cdd:pfam13518   1 ERLKIVLLALEGE-SIKEAARLFGISRSTVYRWIRRYREGGLEGLLPRRRR 50
 
Name Accession Description Interval E-value
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
54-156 1.12e-09

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 52.23  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690924632  54 RHKRSYSPEDKLCVVLYALGHSESLPRVAARFNIpSHNTVKNWIKGYRKSGNEAFirrrkeksmtrSDDTHENEANMTPE 133
Cdd:COG2963     3 KKRRRYSPEFKAEAVRLVLEGGASVAEVARELGI-SPSTLYRWVRQYREGGLGGF-----------PGDGRTTPEQAEIR 70

                          90       100
                  ....*....|....*....|...
gi 1690924632 134 EMKNELRYLRAENAYLKAMQEHL 156
Cdd:COG2963    71 RLRKELRRLEMENDILKKAAALL 93
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 64-113 2.22e-05

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 39.88  E-value: 2.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1690924632  64 KLCVVLYALGHsESLPRVAARFNIpSHNTVKNWIKGYRKSGNEAFIRRRK 113
Cdd:pfam13518   2 RLKIVLLALEG-ESIKEAARLFGI-SRSTVYRWIRRYREGGLEGLLPRRR 49
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 7-57 4.85e-04

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 36.42  E-value: 4.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1690924632   7 VKLAAVNHYLAGHaGIISTAKLFQLSHTSLSHWINLFLLHGPRALDCRHKR 57
Cdd:pfam13518   1 ERLKIVLLALEGE-SIKEAARLFGISRSTVYRWIRRYREGGLEGLLPRRRR 50
 
Name Accession Description Interval E-value
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
54-156 1.12e-09

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 52.23  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1690924632  54 RHKRSYSPEDKLCVVLYALGHSESLPRVAARFNIpSHNTVKNWIKGYRKSGNEAFirrrkeksmtrSDDTHENEANMTPE 133
Cdd:COG2963     3 KKRRRYSPEFKAEAVRLVLEGGASVAEVARELGI-SPSTLYRWVRQYREGGLGGF-----------PGDGRTTPEQAEIR 70

                          90       100
                  ....*....|....*....|...
gi 1690924632 134 EMKNELRYLRAENAYLKAMQEHL 156
Cdd:COG2963    71 RLRKELRRLEMENDILKKAAALL 93
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 64-113 2.22e-05

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 39.88  E-value: 2.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1690924632  64 KLCVVLYALGHsESLPRVAARFNIpSHNTVKNWIKGYRKSGNEAFIRRRK 113
Cdd:pfam13518   2 RLKIVLLALEG-ESIKEAARLFGI-SRSTVYRWIRRYREGGLEGLLPRRR 49
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 7-57 4.85e-04

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 36.42  E-value: 4.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1690924632   7 VKLAAVNHYLAGHaGIISTAKLFQLSHTSLSHWINLFLLHGPRALDCRHKR 57
Cdd:pfam13518   1 ERLKIVLLALEGE-SIKEAARLFGISRSTVYRWIRRYREGGLEGLLPRRRR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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