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Conserved domains on  [gi|1679186165|ref|WP_138796111|]
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glycosyltransferase, partial [Salmonella enterica]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
1-130 1.19e-41

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03809:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 362  Bit Score: 141.35  E-value: 1.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHE 80
Cdd:cd03809   227 VIVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPE 306
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1679186165  81 VLTNGALYVNPDDEKSWQSAIKNIEQLPDAISRFNNY----VARYDFDNMKQMV 130
Cdd:cd03809   307 VAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKglerAKKFSWEKTAEKT 360
 
Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
1-130 1.19e-41

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 141.35  E-value: 1.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHE 80
Cdd:cd03809   227 VIVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPE 306
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1679186165  81 VLTNGALYVNPDDEKSWQSAIKNIEQLPDAISRFNNY----VARYDFDNMKQMV 130
Cdd:cd03809   307 VAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKglerAKKFSWEKTAEKT 360
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
2-107 1.22e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 86.94  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   2 IVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEV 81
Cdd:pfam00534  37 VIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEV 116
                          90       100
                  ....*....|....*....|....*....
gi 1679186165  82 LT---NGALYvnpdDEKSWQSAIKNIEQL 107
Cdd:pfam00534 117 VKdgeTGFLV----KPNNAEALAEAIDKL 141
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
37-126 2.13e-19

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 77.72  E-value: 2.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  37 LKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNG--ALYVNPDDEKSWQSAIKNIEQLPDAISRF 114
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGetGLLVPPGDPEALAEAILRLLEDPELRRRL 93
                          90
                  ....*....|....*..
gi 1679186165 115 -----NNYVARYDFDNM 126
Cdd:COG0438    94 geaarERAEERFSWEAI 110
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
36-124 2.88e-11

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 59.33  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  36 ELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDI-PVFHEVLTNGALYVNPDDEKSWQSAIKNI---EQLPDAI 111
Cdd:TIGR04047 269 DLPALYRCADAFAFPSLKEGFGLVVLEALASGIPVVASDIaPFTEYLGRFDAAWADPSDPDSIADALALAldpARRPALR 348
                          90
                  ....*....|...
gi 1679186165 112 SRFNNYVARYDFD 124
Cdd:TIGR04047 349 AAGPELAARYTWD 361
PLN02949 PLN02949
transferase, transferring glycosyl groups
12-79 1.52e-07

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 48.97  E-value: 1.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1679186165  12 SLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTpvivsdIPVFH 79
Cdd:PLN02949  323 KLKDRAKELGLDGDVEFHKNVSYRDLVRLLGGAVAGLHSMIDEHFGISVVEYMAAGA------VPIAH 384
 
Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
1-130 1.19e-41

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 141.35  E-value: 1.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHE 80
Cdd:cd03809   227 VIVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPE 306
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1679186165  81 VLTNGALYVNPDDEKSWQSAIKNIEQLPDAISRFNNY----VARYDFDNMKQMV 130
Cdd:cd03809   307 VAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKglerAKKFSWEKTAEKT 360
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
2-107 1.22e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 86.94  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   2 IVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEV 81
Cdd:pfam00534  37 VIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEV 116
                          90       100
                  ....*....|....*....|....*....
gi 1679186165  82 LT---NGALYvnpdDEKSWQSAIKNIEQL 107
Cdd:pfam00534 117 VKdgeTGFLV----KPNNAEALAEAIDKL 141
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
1-126 8.11e-21

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 86.05  E-value: 8.11e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAMS-LQQMvvDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFH 79
Cdd:cd03801   226 LVIVGGDGPLRAeLEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLP 303
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1679186165  80 EVLTNG--ALYVNPDDEKSWQSAIKNI---EQLPDAISR--FNNYVARYDFDNM 126
Cdd:cd03801   304 EVVEDGegGLVVPPDDVEALADALLRLladPELRARLGRaaRERVAERFSWERV 357
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
37-126 2.13e-19

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 77.72  E-value: 2.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  37 LKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNG--ALYVNPDDEKSWQSAIKNIEQLPDAISRF 114
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGetGLLVPPGDPEALAEAILRLLEDPELRRRL 93
                          90
                  ....*....|....*..
gi 1679186165 115 -----NNYVARYDFDNM 126
Cdd:COG0438    94 geaarERAEERFSWEAI 110
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
1-101 1.64e-15

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 67.92  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAmSLQQMVVDLElkDKVTFLHEVsfNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHE 80
Cdd:pfam13692  36 LVIVGDGPEE-ELEELAAGLE--DRVIFTGFV--EDLAELLAAADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPE 110
                          90       100
                  ....*....|....*....|...
gi 1679186165  81 VLT--NGALyVNPDDEKSWQSAI 101
Cdd:pfam13692 111 LVDgeNGLL-VPPGDPEALAEAI 132
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
13-130 3.02e-15

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 70.87  E-value: 3.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  13 LQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNG--ALYVN 90
Cdd:cd03798   246 LRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPetGLLVP 325
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1679186165  91 PDDEKSWQSAIK------NIEQLPDAISRfnNYVARYDFDNMKQMV 130
Cdd:cd03798   326 PGDADALAAALRralaepYLRELGEAARA--RVAERFSWVKAADRI 369
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
13-102 1.58e-13

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 65.72  E-value: 1.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  13 LQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNG--ALYVN 90
Cdd:cd03800   272 LAELAEELGLIDRVRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGrtGLLVD 351
                          90
                  ....*....|..
gi 1679186165  91 PDDEKSWQSAIK 102
Cdd:cd03800   352 PHDPEALAAALR 363
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
2-124 5.70e-13

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 64.22  E-value: 5.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   2 IVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEV 81
Cdd:cd03817   235 VIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASEL 314
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1679186165  82 L---TNGALYvnPDDEKSWQSAIKNIEQLPDAISR----FNNYVARYDFD 124
Cdd:cd03817   315 VedgENGFLF--EPNDETLAEKLLHLRENLELLRKlsknAEISAREFAFA 362
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
13-129 2.05e-11

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 60.00  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  13 LQQMVVDLELKDKVTFLHEVsfNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNGALYVNPD 92
Cdd:cd03812   237 IKEKVKELGLEDKVIFLGFR--NDVSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCLLSDTITKECDITNNVEFLPLN 314
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1679186165  93 D-EKSWQSAIKNieqLPDAISRFNNYVARYDFDNMKQM 129
Cdd:cd03812   315 EtPSTWAEKILK---LIKRKRRINKEINKEKKELGYDD 349
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
14-108 2.25e-11

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 59.69  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  14 QQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNGALYVNPDD 93
Cdd:cd03821   252 LQLQSSLGLGDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPN 331
                          90
                  ....*....|....*
gi 1679186165  94 EKSWQSAIKNIEQLP 108
Cdd:cd03821   332 VSSLAEALAEALRDP 346
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
9-74 2.75e-11

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 59.52  E-value: 2.75e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1679186165   9 YAMSLQQMVVDLE-LKDKVTFLHEVSfNELKI-LYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSD 74
Cdd:cd03805   264 YLEELQRLAEELLnVEDQVLFLRSIS-DSQKEqLLSSALALLYTPSNEHFGIVPLEAMYAGKPVIACN 330
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
36-124 2.88e-11

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 59.33  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  36 ELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDI-PVFHEVLTNGALYVNPDDEKSWQSAIKNI---EQLPDAI 111
Cdd:TIGR04047 269 DLPALYRCADAFAFPSLKEGFGLVVLEALASGIPVVASDIaPFTEYLGRFDAAWADPSDPDSIADALALAldpARRPALR 348
                          90
                  ....*....|...
gi 1679186165 112 SRFNNYVARYDFD 124
Cdd:TIGR04047 349 AAGPELAARYTWD 361
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
18-114 8.72e-11

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 58.05  E-value: 8.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  18 VDLELKDKVTFLHEVSFNELKILYSKAYALVYPSI--DEGFGIPPIEAMASNTPVIVSDIP---VFheVLTNG--ALYVN 90
Cdd:cd03795   236 IELNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVISTNIGtgvPY--VNNNGetGLVVP 313
                          90       100
                  ....*....|....*....|....
gi 1679186165  91 PDDEKSWQSAIKNIEQLPDAISRF 114
Cdd:cd03795   314 PKDPDALAEAIDKLLSDEELRESY 337
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
21-114 2.50e-10

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 56.91  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  21 ELKDK----VTFLHEVSFNELKILYSKAYALVYPSiDEGFGIPPIEAMASNTPVIVSDipvfhevlTNGALYVNPDDEKS 96
Cdd:cd03804   239 RLRAMaspnVEFLGYQPDEVLKELLSKARAFVFAA-EEDFGIVPVEAQACGTPVIAFG--------KGGALETVRPGPTG 309
                          90
                  ....*....|....*...
gi 1679186165  97 WQSAIKNIEQLPDAISRF 114
Cdd:cd03804   310 ILFGEQTVESLKAAVEEF 327
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
13-109 7.63e-10

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 55.44  E-value: 7.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  13 LQQMVVDLELKDKVTFLHEVS--FNELKilysKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNG--ALY 88
Cdd:cd03811   234 LEKLAKELGLAERVIFLGFQSnpYPYLK----KADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGenGLL 309
                          90       100
                  ....*....|....*....|.
gi 1679186165  89 VNPDDEKSWQSAIKNIEQLPD 109
Cdd:cd03811   310 VPDGDAAALAGILAALLQKKL 330
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
1-88 1.03e-09

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 54.33  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVY-PSIDEGFGIPPIEAMASNTPVIVSD---IP 76
Cdd:cd01635   144 LVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADVFVlPSRSEGFGLVLLEAMAAGKPVIATDvggIP 223
                          90
                  ....*....|..
gi 1679186165  77 VFHEVLTNGALY 88
Cdd:cd01635   224 EFVVDGENGLLV 235
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
12-126 3.54e-09

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 53.37  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  12 SLQQMVVDLELKDKVTFLHEVSfnELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIP-----VFHEVltNGA 86
Cdd:cd03808   234 PSEILIEKLGLEGRIEFLGFRS--DVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPgcrelVIDGV--NGF 309
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1679186165  87 LyVNPDDEKSWQSAIKNIEQLPDAISRFNN-----YVARYDFDNM 126
Cdd:cd03808   310 L-VPPGDVEALADAIEKLIEDPELRKEMGEaarkrVEEKFDEEKV 353
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
12-123 8.16e-09

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 52.24  E-value: 8.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  12 SLQQMVVDLELKDKVTFLHevSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIP------VFHEVltNG 85
Cdd:cd03820   226 ELEKLIDKLGLEDRVKLLG--PTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPtgpseiIEDGE--NG 301
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1679186165  86 ALyVNPDDekswqsaiknIEQLPDAISRF-NNYVARYDF 123
Cdd:cd03820   302 LL-VPNGD----------VDALAEALLRLmEDEELRKKM 329
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
7-79 2.60e-08

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 51.07  E-value: 2.60e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1679186165   7 TDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTpvivsdIPVFH 79
Cdd:cd03806   288 KERVEALKLLAKELILEDSVEFVVDAPYEELKELLSTASIGLHTMWNEHFGIGVVEYMAAGL------IPLAH 354
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
20-113 2.78e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 50.79  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  20 LELKDKVTFLHEVSFNELKILYSKAYALVYPSI-DEGFGIPPIEAMASNTPVIVSDI-----PVFHEVltNGaLYVNPDD 93
Cdd:cd03823   237 IEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLggiaeLIQPGV--NG-LLFAPGD 313
                          90       100
                  ....*....|....*....|
gi 1679186165  94 EKSWQSAIKNIEQLPDAISR 113
Cdd:cd03823   314 AEDLAAAMRRLLTDPALLER 333
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
22-110 4.25e-08

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 50.43  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  22 LKDKVTFLhevSFNE-LKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNGA--LYVNPDDEKSWQ 98
Cdd:cd03819   236 LRDRVTFT---GFREdVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRtgLLVPPGDAEALA 312
                          90
                  ....*....|..
gi 1679186165  99 SAIKNIEQLPDA 110
Cdd:cd03819   313 DAIRAAKLLPEA 324
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
4-111 5.70e-08

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 50.01  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   4 CGRTDyamsLQQMVVDLELKDKVTFLHEVSfnELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLT 83
Cdd:cd03807   231 PERPN----LERLLLELGLEDRVHLLGERS--DVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVD 304
                          90       100
                  ....*....|....*....|....*...
gi 1679186165  84 NGALYVNPDdekswqsaiKNIEQLPDAI 111
Cdd:cd03807   305 DGTGFLVPA---------GDPQALADAI 323
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
6-122 8.98e-08

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 49.21  E-value: 8.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   6 RTDYAMSLQQmvvdLELKDKVTFLHEVSFNELKILYSKAYALVYPSI-DEGFGIPPIEAMASNTPVI------VSDIPVF 78
Cdd:cd03802   206 DEDYFYYLQE----PLPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIayrrggLPEVIQH 281
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1679186165  79 HEVltnGALyVNPDDEKSwqSAIKNIEQLPD------AISRF------NNYVARYD 122
Cdd:cd03802   282 GET---GFL-VDSVEEMA--EAIANIDRIDRaacrryAEDRFsaarmaDRYEALYR 331
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
26-101 9.59e-08

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 49.21  E-value: 9.59e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1679186165  26 VTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLT---NGALyVNPDDEKSWQSAI 101
Cdd:cd03814   250 VIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRpggTGAL-VEPGDAAAFAAAL 327
PLN02949 PLN02949
transferase, transferring glycosyl groups
12-79 1.52e-07

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 48.97  E-value: 1.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1679186165  12 SLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTpvivsdIPVFH 79
Cdd:PLN02949  323 KLKDRAKELGLDGDVEFHKNVSYRDLVRLLGGAVAGLHSMIDEHFGISVVEYMAAGA------VPIAH 384
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
15-93 5.54e-07

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 46.96  E-value: 5.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165  15 QMVVDLELKDKVTFLHevSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNG--ALYVNPD 92
Cdd:cd04962   243 ELARELGVEDRVLFLG--KQDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGetGFLSDVG 320

                  .
gi 1679186165  93 D 93
Cdd:cd04962   321 D 321
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
8-126 2.55e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 45.40  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   8 DYAMSLQQMVVDLELKDKVTFLhevSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNGA- 86
Cdd:cd03813   338 EYAQECKRLVASLGLENKVKFL---GFQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIYGADd 414
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1679186165  87 ------LYVNPDDEKSWQSAIKNIEQLPDAISRF-NNYVAR----YDFDNM 126
Cdd:cd03813   415 algqagLVVPPADPEALAEALIKLLRDPELRQAFgEAGRKRvekyYTLEGM 465
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
5-76 4.88e-05

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 41.52  E-value: 4.88e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1679186165   5 GRTDYAMSLQQMVVDLELKDKVTF--LHevsfNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIP 76
Cdd:cd04949   198 GYGEEREKLKKLIEELHLEDNVFLkgYH----SNLDQEYQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVK 267
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
13-84 5.87e-05

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 41.28  E-value: 5.87e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1679186165  13 LQQMVVDLELKDKVTFLHEVSfnELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTN 84
Cdd:cd04951   234 LERLICNLNLVDRVILLGQIS--NISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGD 303
PHA01633 PHA01633
putative glycosyl transferase group 1
20-80 1.09e-04

putative glycosyl transferase group 1


Pssm-ID: 107050 [Multi-domain]  Cd Length: 335  Bit Score: 40.35  E-value: 1.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1679186165  20 LELKDKVTFLHEVSFNELKILYSKAYALVY---PSIDEGFGIPPIEAMASNTPVIVSDIPVFHE 80
Cdd:PHA01633  197 LEVPANVHFVAEFGHNSREYIFAFYGAMDFtivPSGTEGFGMPVLESMAMGTPVIHQLMPPLDE 260
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
36-75 1.10e-04

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 40.39  E-value: 1.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1679186165  36 ELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDI 75
Cdd:cd03825   256 QLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDT 295
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
1-104 1.14e-04

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 40.40  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679186165   1 IIVCGRTDYAMSLQQMVVDLELkDKVTFLHEVSFNELKILYSKAYALVYP---SIDEGFGIP--PIEAMASNTPVIVSDI 75
Cdd:cd03794   250 FLFVGDGDEKERLKELAKARGL-DNVTFLGRVPKEEVPELLSAADVGLVPlkdNPANRGSSPskLFEYMAAGKPILASDD 328
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1679186165  76 P--VFHEVLTNGALYVNPDDEKSWQSAIKNI 104
Cdd:cd03794   329 GgsDLAVEINGCGLVVEPGDPEALADAILEL 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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