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Conserved domains on  [gi|1654901356|ref|WP_137490756|]
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site-specific DNA-methyltransferase, partial [Escherichia coli]

Protein Classification

site-specific DNA-methyltransferase( domain architecture ID 10480401)

site-specific DNA-methyltransferase catalyzes specific methylation on cytosine or adenine and protects the DNA from cleavage by endonuclease

EC:  2.1.1.-
Gene Ontology:  GO:0003677|GO:0009307|GO:0008170

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 140-232 8.75e-28

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


:

Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 105.56  E-value: 8.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654901356 140 SEYKNLRRYFGVTVQVPYTDVWTYKPVQYYP------GKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMAL 213
Cdd:pfam01555 123 DEKDKLKKRGSEPNGKPIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKEL 202

                          90
                  ....*....|....*....
gi 1654901356 214 GRRAIGVELETGRFEQTVR 232
Cdd:pfam01555 203 GRNFIGIEIEEEYVEIAKE 221
 
Name Accession Description Interval E-value
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 140-232 8.75e-28

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 105.56  E-value: 8.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654901356 140 SEYKNLRRYFGVTVQVPYTDVWTYKPVQYYP------GKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMAL 213
Cdd:pfam01555 123 DEKDKLKKRGSEPNGKPIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKEL 202

                          90
                  ....*....|....*....
gi 1654901356 214 GRRAIGVELETGRFEQTVR 232
Cdd:pfam01555 203 GRNFIGIEIEEEYVEIAKE 221
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
158-223 3.53e-25

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 98.84  E-value: 3.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1654901356 158 TDVWTYKPVQY-YPGKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMALGRRAIGVELE 223
Cdd:COG0863   147 SDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEID 213
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
152-224 1.75e-13

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 68.21  E-value: 1.75e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1654901356 152 TVQVPyTDVWTYKPVQY----YPgKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMALGRRAIGVELET 224
Cdd:PRK11524  166 TQKVP-GNVWDFPRVRYlmdeYE-NHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINS 240
 
Name Accession Description Interval E-value
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 140-232 8.75e-28

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 105.56  E-value: 8.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654901356 140 SEYKNLRRYFGVTVQVPYTDVWTYKPVQYYP------GKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMAL 213
Cdd:pfam01555 123 DEKDKLKKRGSEPNGKPIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKEL 202

                          90
                  ....*....|....*....
gi 1654901356 214 GRRAIGVELETGRFEQTVR 232
Cdd:pfam01555 203 GRNFIGIEIEEEYVEIAKE 221
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
158-223 3.53e-25

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 98.84  E-value: 3.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1654901356 158 TDVWTYKPVQY-YPGKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMALGRRAIGVELE 223
Cdd:COG0863   147 SDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEID 213
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
176-223 1.53e-13

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 69.42  E-value: 1.53e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1654901356 176 EKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMALG------RRAIGVELE 223
Cdd:COG2189   304 PKPEKLLKRIIEIATNPGDLVLDFFAGSGTTAHAVMKLNaedggnRRFILVQLG 357
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
152-224 1.75e-13

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 68.21  E-value: 1.75e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1654901356 152 TVQVPyTDVWTYKPVQY----YPgKHPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMALGRRAIGVELET 224
Cdd:PRK11524  166 TQKVP-GNVWDFPRVRYlmdeYE-NHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINS 240
PRK13699 PRK13699
putative methylase; Provisional
 154-222 1.15e-12

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 65.24  E-value: 1.15e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1654901356 154 QVPYTDVWTYKpvqyYPGK--HPCEKPAEMLQQIISASSRPGDLVADFFMGSGSTVKAAMALGRRAIGVEL 222
Cdd:PRK13699  127 QNPLPDVLGWK----YSGNrhHPTEKPVTSLQPLIESFTHPNAIVLDPFAGSGSTCVAALQSGRRYIGIEL 193
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 188-223 7.00e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 39.16  E-value: 7.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1654901356 188 ASSRPGDLVADFFMGSGSTVKAAMALGRRAIGVELE 223
Cdd:COG1041    22 AGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDID 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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