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Conserved domains on  [gi|1592456841|ref|WP_132356505|]
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recombinase family protein [Photorhabdus khanii]

Protein Classification

recombinase family protein( domain architecture ID 11449350)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0015074|GO:0000150|GO:0003677
PubMed:  11972771|16077726|9348666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 6-188 6.09e-49

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


:

Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 163.27  E-value: 6.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   6 IGYARCSTDRQ---DLTVQQEALIKL----GVSPDRIYIDKGLTGSNRQRPGLDQALAAVRSG--DMLVVPKLDRLARSV 76
Cdd:COG1961     5 AGYARVSTDDQeglSLERQREALRAYaekaGWEIVRIYVDEGVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGRNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841  77 PDAREIADALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGKLRGKQP--------- 147
Cdd:COG1961    85 ADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRPPygyrdpkkl 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1592456841 148 KLSEKQQKELCRMRE--TGKYSISDLADLF------SVSRPTVYRTLSR 188
Cdd:COG1961   165 VIDEEEAEVVRRIFElyLEGKSLREIARELnergipTWSRSTVYRILKN 213
 
Name Accession Description Interval E-value
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 6-188 6.09e-49

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 163.27  E-value: 6.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   6 IGYARCSTDRQ---DLTVQQEALIKL----GVSPDRIYIDKGLTGSNRQRPGLDQALAAVRSG--DMLVVPKLDRLARSV 76
Cdd:COG1961     5 AGYARVSTDDQeglSLERQREALRAYaekaGWEIVRIYVDEGVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGRNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841  77 PDAREIADALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGKLRGKQP--------- 147
Cdd:COG1961    85 ADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRPPygyrdpkkl 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1592456841 148 KLSEKQQKELCRMRE--TGKYSISDLADLF------SVSRPTVYRTLSR 188
Cdd:COG1961   165 VIDEEEAEVVRRIFElyLEGKSLREIARELnergipTWSRSTVYRILKN 213
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 5-132 1.68e-48

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 153.79  E-value: 1.68e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   5 RIGYARCSTDRQDLTVQQEALIKLGvSPDRIYIDKGlTGSNRQRPGLDQALAAVRSGDMLVVPKLDRLARSVPDAREIAD 84
Cdd:cd03768     1 VIGYARVSTDDQSLERQLEALKAAG-ECDKIFEEKG-SGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1592456841  85 ALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREG 132
Cdd:cd03768    79 ELREKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 5-142 6.61e-44

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 142.79  E-value: 6.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   5 RIGYARCSTDRQD--LTVQQEALIKLGVSPDRI--YIDKGLTGSNRQRPGLDQALAAVRS--GDMLVVPKLDRLARSVPD 78
Cdd:pfam00239   1 AIGYARVSTEDQDdsLERQLEALRAYAACNGKIveFEDKGVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1592456841  79 AREIADALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGKL 142
Cdd:pfam00239  81 LLTLVEELREKGVDLVSLDEGIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 6-141 2.12e-41

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 136.60  E-value: 2.12e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841    6 IGYARCSTDRQ---DLTVQQEALIKL----GVSPDRIYIDKGLTGSNRQRPGLDQALAAVRSGD--MLVVPKLDRLARSV 76
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALRAYaernGWEVVRIYEDEGVSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1592456841   77 PDAREIADALQARGVKL-ALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGK 141
Cdd:smart00857  82 RDLLALLELLEEKGVRLvSLKEGILDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGR 147
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
6-188 1.41e-10

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 57.80  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   6 IGYARCSTDRQDLTVQQEALIKL----GVSPDRiYIDKGLTGS----NRQrpgLDQALAAVRSGDMLVVPKLDRLARSVP 77
Cdd:PRK13413    3 YAYIRVSTDKQTVENQRFEITNFaeknNLTIDK-WIEETISGTksykDRK---LGKLLKKMRKGDILIVSELSRLGRNLM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841  78 DAREIADALQARGVKL-------ALGTNIYDpadpmgkmffNVLA-TF---AEFEGDLIRLRTREGMAIARAKGKLRG-- 144
Cdd:PRK13413   79 EIMSILNICMEKEVIVytikegyELGDDINS----------KVLAfAFglsAEIERNLISQRTKEALARKKAEGVTLGrp 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1592456841 145 -----KQPKLSEKqQKELCRMRETGKySISDLADLFSVSRPTVYRTLSR 188
Cdd:PRK13413  149 kgstpKKYKLTGK-EEKIKKLLDKGT-SKSEIARKLGVSRTTLARFLKT 195
 
Name Accession Description Interval E-value
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 6-188 6.09e-49

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 163.27  E-value: 6.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   6 IGYARCSTDRQ---DLTVQQEALIKL----GVSPDRIYIDKGLTGSNRQRPGLDQALAAVRSG--DMLVVPKLDRLARSV 76
Cdd:COG1961     5 AGYARVSTDDQeglSLERQREALRAYaekaGWEIVRIYVDEGVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGRNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841  77 PDAREIADALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGKLRGKQP--------- 147
Cdd:COG1961    85 ADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRPPygyrdpkkl 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1592456841 148 KLSEKQQKELCRMRE--TGKYSISDLADLF------SVSRPTVYRTLSR 188
Cdd:COG1961   165 VIDEEEAEVVRRIFElyLEGKSLREIARELnergipTWSRSTVYRILKN 213
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 5-132 1.68e-48

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 153.79  E-value: 1.68e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   5 RIGYARCSTDRQDLTVQQEALIKLGvSPDRIYIDKGlTGSNRQRPGLDQALAAVRSGDMLVVPKLDRLARSVPDAREIAD 84
Cdd:cd03768     1 VIGYARVSTDDQSLERQLEALKAAG-ECDKIFEEKG-SGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1592456841  85 ALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREG 132
Cdd:cd03768    79 ELREKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 5-142 6.61e-44

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 142.79  E-value: 6.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   5 RIGYARCSTDRQD--LTVQQEALIKLGVSPDRI--YIDKGLTGSNRQRPGLDQALAAVRS--GDMLVVPKLDRLARSVPD 78
Cdd:pfam00239   1 AIGYARVSTEDQDdsLERQLEALRAYAACNGKIveFEDKGVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1592456841  79 AREIADALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGKL 142
Cdd:pfam00239  81 LLTLVEELREKGVDLVSLDEGIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 6-141 2.12e-41

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 136.60  E-value: 2.12e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841    6 IGYARCSTDRQ---DLTVQQEALIKL----GVSPDRIYIDKGLTGSNRQRPGLDQALAAVRSGD--MLVVPKLDRLARSV 76
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALRAYaernGWEVVRIYEDEGVSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1592456841   77 PDAREIADALQARGVKL-ALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREGMAIARAKGK 141
Cdd:smart00857  82 RDLLALLELLEEKGVRLvSLKEGILDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGR 147
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 8-132 1.64e-27

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 100.80  E-value: 1.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   8 YARCSTDRQD----LTVQQEALIKL----GVSPDRIYIDKGLTGS-NRQRPGLDQALAAVRSG--DMLVVPKLDRLARSV 76
Cdd:cd00338     2 YARVSTDKQEqgdsLERQREALREYaarnGLEVVGEYEDAGSSATsLVDRPGLQRLLADVKAGkiDVVLVEKLDRLSRNL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1592456841  77 PDAREIADALQARGVKLALGTNIYDPADPMGKMFFNVLATFAEFEGDLIRLRTREG 132
Cdd:cd00338    82 VDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESKLISERTKRG 137
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
6-188 1.41e-10

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 57.80  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   6 IGYARCSTDRQDLTVQQEALIKL----GVSPDRiYIDKGLTGS----NRQrpgLDQALAAVRSGDMLVVPKLDRLARSVP 77
Cdd:PRK13413    3 YAYIRVSTDKQTVENQRFEITNFaeknNLTIDK-WIEETISGTksykDRK---LGKLLKKMRKGDILIVSELSRLGRNLM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841  78 DAREIADALQARGVKL-------ALGTNIYDpadpmgkmffNVLA-TF---AEFEGDLIRLRTREGMAIARAKGKLRG-- 144
Cdd:PRK13413   79 EIMSILNICMEKEVIVytikegyELGDDINS----------KVLAfAFglsAEIERNLISQRTKEALARKKAEGVTLGrp 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1592456841 145 -----KQPKLSEKqQKELCRMRETGKySISDLADLFSVSRPTVYRTLSR 188
Cdd:PRK13413  149 kgstpKKYKLTGK-EEKIKKLLDKGT-SKSEIARKLGVSRTTLARFLKT 195
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
 144-186 9.12e-09

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 49.25  E-value: 9.12e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1592456841 144 GKQPKLSEKQQKELCRMRETGKySISDLADLFSVSRPTVYRTL 186
Cdd:cd00569     1 GRPPKLTPEQIAEARRLLAAGE-SVAEIARELGVSRSTLYRYL 42
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 4-94 2.43e-07

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 48.09  E-value: 2.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592456841   4 IRIgYARCSTDRQDLTVQQEALIKL----GVSPDRIYIDKgLTGSNRQRPGLDQALAAVRSGDMLVVPKLDRLAR-SVPD 78
Cdd:cd03767     1 IRA-YLRASTDEQDATRAKESLEAFaterGFYIAGFYVEN-ASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRlPLDD 78

                          90
                  ....*....|....*.
gi 1592456841  79 AREIADALQARGVKLA 94
Cdd:cd03767    79 WETLKASIAAKGLRVV 94
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
144-187 6.51e-06

Helix-turn-helix domain of resolvase;


Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 41.57  E-value: 6.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1592456841 144 GKQPKLSEKQQKELCRMRETGkYSISDLADLFSVSRPTVYRTLS 187
Cdd:pfam02796   1 GRPPKLNEEDINEVITLLEEG-ISIKQIAKIFGISRSTVYRYLA 43
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 34-74 4.46e-03

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 35.81  E-value: 4.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1592456841  34 RIYIDKGLTGSNRQRPGLDQALAAVRSG--DMLVVPKLDRLAR 74
Cdd:cd03770    40 RHYIDDGFSGTTFDRPGFNRMIEDIEAGkiDIVIVKDMSRLGR 82
MviM COG0673
Predicted dehydrogenase [General function prediction only];
52-103 8.33e-03

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 36.05  E-value: 8.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1592456841  52 DQALAAVRSG-DMLV-VPkldrLARSVPDAREIADALQARGVKLALGTN-IYDPA 103
Cdd:COG0673    79 ELAIAALEAGkHVLCeKP----LALTLEEARELVAAAEEAGVVLMVGFNrRFDPA 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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